CN1211436A - Medicine for preventing and curing bleeding side reaction after abortion by drug - Google Patents
Medicine for preventing and curing bleeding side reaction after abortion by drug Download PDFInfo
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- CN1211436A CN1211436A CN 97116450 CN97116450A CN1211436A CN 1211436 A CN1211436 A CN 1211436A CN 97116450 CN97116450 CN 97116450 CN 97116450 A CN97116450 A CN 97116450A CN 1211436 A CN1211436 A CN 1211436A
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Abstract
A medicine for preventing and curing hemorrhage as by-reaction after pharmaceutical abortion is prepared from 10 Chinese-medicinal materials such as Chinese angelica root, Chuan-xiong rhizome, safflower, motherwort, cat-tail pollen, etc through decocting, low-temp concentrating, purifying with alcohol, vacuum distillation to recover alcohol and addition of antiseptic to obtain oral liquid, or addition of excipient to granulate. It serves to decrease bleeding time and quality and relax pain.
Description
The present invention relates to a kind of pharmaceutical product that contains Chinese medicinal ingredients, particularly a kind of medicine of preventing and treating bleeding side reaction after abortion by drug.
At present women of child-bearing age's gestation outside the plan being stopped by miscarriage is unique remedial measure.Nonoperative drug induced abortion (being called for short medicine stream) is avoided operation miscarriage uteroventral operation and complication, in national widespread usage because of easy, efficient, no wound.But the major defect of this method is to have the hemorrhage after drug abortion side reaction.
In recent years, the dialectical use of medicine stream back typing SHENGHUATANG in puerperal, dispel silt soup, YUNNAN BAIYAO etc. have obtained certain curative effect.
" Yunnan Chinese medicine magazine " 1996 the 17th volumes the 1st phase report " SHENGHUATANG medicine colporrhagia due to abortion in puerperal ", be to fry in shallow oil together, obtain curative effect with Radix Angelicae Sinensis, Rhizoma Chuanxiong, Flos Carthami, Herba Leonuri, Herba Lycopi, Semen Persicae, Radix Glycyrrhizae Preparata, Rhizoma Zingiberis Preparatum, Fructus Crataegi cuneatae and wine.
" Journal of Traditional Chinese Medicine " 1996 the 37th volumes the 10th phase report " clinical observation of treatment by Chinese herbs vaginal bleeding after drug abortion ", the use palace soup that contracts, promptly Radix Angelicae Sinensis, Rhizoma Chuanxiong, Radix Rubiae, Pollen Typhae, GUANZHONGTAN, Rhizoma Cyperi, Flos Carthami, Semen Persicae, Fructus Schisandrae Chinensis, Rhizoma Zingiberis Preparatum, Herba Leonuri, Radix Codonopsis, the Radix Astragali, Rhizoma Atractylodis Macrocephalae Radix Glycyrrhizae Preparata are decocted in water for oral dose.
" the new traditional Chinese medical science " 1997 the 29th the 7th phases of volume are introduced " the peaceful bagged steeping drug of woman is treated the hemorrhage clinical observation on the therapeutic effect of 300 routine drug induced abortioies ", and Herba Leonuri, Radix Arnebiae (Radix Lithospermi), Pollen Tyjphae, Oletum Trogopterori are made granule, and boiled water is taken after being infused in hot water or decoction, and obtains better curative effect.
The objective of the invention is for a kind of bleeding side reaction after abortion by drug and painful medicine of alleviating is provided.
Another object of the present invention is the medicine of the different dosage form taken for the patient that provides convenience.
The present invention is by following conceptual design.Pharmaceutical formulation of the present invention and weight portion proportioning:
Radix Angelicae Sinensis 8-20 Rhizoma Chuanxiong 7-15 Flos Carthami 7-15 Herba Leonuri 10-40
Pollen Typhae 7-15 Oletum Trogopterori 7-15 Fructus Aurantii 8-15 Herba Artemisiae Anomalae 8-15
Optimum weight part proportioning of Rhizoma Zingiberis Preparatum 4-8 Radix Glycyrrhizae Preparata 4-8 pharmaceutical formulation of the present invention:
Radix Angelicae Sinensis 10 Rhizoma Chuanxiongs 10 Flos Carthamis 10 Herba Leonuris 15
Pollen Typhae 10 Oletum Trogopteroris 10 Fructus Aurantiis 10 Herba Artemisiae Anomalaes 10
Rhizoma Zingiberis Preparatum 5 Radix Glycyrrhizae Preparatas 5
Press the medicine of the control bleeding side reaction after abortion by drug of above prescription and proportioning preparation, have the following advantages:
(1) hemostasia effect is remarkable, can significantly shorten the bleeding time (shortening for 2/3rds times) behind the medicine, can significantly reduce the amount of bleeding (reducing 1/2nd) behind the medicine stream again, can also significantly alleviate the stomachache that medicine stream causes, feels good.
(2) multipath control hemorrhage after drug abortion:
1. nutrition uterus, blood-supplementing blood-nourishing, muscle strength reinforcing is dual regulation to the uterus, impels and discharges the uterine pregnancy residue.
2. eliminate microcirculation disturbance, correct uterus local blood thickness, sluggish state, promote intrauterine membranization silt tissue regeneration promoting.
3. invigorate blood circulation, stop blooding, the balance coagulation function.
4. cooperate analgesic effect, heighten the effect of a treatment.
Medicine of the present invention is through 500 routine large sample clinical verifications, and compares with the normal drug induced abortion women of 100 examples, and the result proves:
Take medicine patient medicine stream of the present invention average only 5.12 ± 2.95 days bleeding time (P＜0.001) of back, average bleeding similar to menstrual blood loss (P＜0.001), wherein obvious effective rate 91%, effective percentage 6%, total effective rate 97%, invalid 3% (be defined as the back bleeding time of taking medicine surpass 15 days, amount of bleeding is more than the twice menstrual blood volume, or need clearing heat in the pericardium hemostasis, pathologic finding has residual fine hair or decidua person).
Below in conjunction with embodiment it is described for preparation method, usage and the consumption of the different dosage form of medicine of the present invention.
The preparation method of embodiment 1-decoct:
Take by weighing pharmaceutical decocting piece Radix Angelicae Sinensis 10 gram, Rhizoma Chuanxiong 10 grams, Flos Carthami 10 grams,
Herba Leonuri 15 grams, Herba Artemisiae Anomalae 10 grams, Pollen Typhae 10 restrain, Oletum Trogopterori 10 restrains,
Fructus Aurantii 10 grams, Rhizoma Zingiberis Preparatum 5 grams, Radix Glycyrrhizae Preparata 5 grams.
Add cold water soak 1-2 hour fully moistening, add water and surpass powder, heated and boiled with high heat, is used slow fire instead after boiling before boiling, and keeps little boiling, the time add stirring, a decoction was boiled 20-30 minute; Two decoctions were boiled 15-20 minute.Collecting decoction 80 order mesh screens filter, every dose of about 300ml.Because of being easily mould losing of water logging preparation, so need prepared fresh to take.
Usage and consumption: everyone parts 5 doses, 1 day 1 dose, divide twice (medicine) being taken before meal usefulness sooner or later, first dosage doubles, and shakes all back decoction being taken warmly.
The preparation method of embodiment 2-oral liquid:
In conjunction with the embodiments 1, the gained decoct is equivalent to crude drug in whole 1 in 60 ℃ of cryoconcentration to every milliliter for 300 milliliters and restrains, be 95 milliliters of concentrated solutions, cooling adds 266 milliliters of 2.8 times of amount 95% alcohol meters slightly, is mixed, placed 12 hours, filter, gained filtrate is reclaimed ethanol through distilling under reduced pressure, is evaporated to 100 milliliters every dose, add antiseptic 0.25% benzoic acid and 0.05% nipalgin, fill, sterilization, sealing are standby.The oral liquid relative density of making is not less than 1.06, pH value 4.5-5.5.
Usage and consumption: everyone parts 5 doses, 1 day 1 dose, divide twice (medicine) being taken before meal usefulness sooner or later, each 50 milliliters, first dose doubles, and shakes all back decoction being taken warmly.
The preparation side of embodiment 3-granule goes:
In conjunction with the embodiments 1,2,1000 milliliters of oral liquids are continued low-temperature evaporation again be concentrated into the thick paste shape, every milliliter of suitable crude drug in whole 5 grams, with 1: the 3-4 ratio is mixed for excipient with sucrose 570-760 gram, it is suitable that to add 70% ethanol be that wetting agent is made soft material, cross 12 eye mesh screens and granulate, put 60 ℃ of following intensive dryings, granulate sieves, screen out fine powder and cross fine grained, packing 40 grams are that one bag of sealing is standby.
Assay: measure the active ingredient ferulic acid with reversed-phase high pressure liquid chromatography, content is no less than 0.13mg in every gram granule.Usage and consumption: 10 bags of everyone parts, divide twice (medicine) being taken before meal usefulness sooner or later every day, each 1 bag, first dose doubles.
Claims (2)
1. medicine of preventing and treating bleeding side reaction after abortion by drug is characterized in that this pharmaceutical formulation and weight portion proportioning are:
Radix Angelicae Sinensis 8-20 Rhizoma Chuanxiong 7-15 Flos Carthami 7-15 Herba Leonuri 10-40
Pollen Typhae 7-15 Oletum Trogopterori 7-15 Fructus Aurantii 8-15 Herba Artemisiae Anomalae 8-15
Rhizoma Zingiberis Preparatum 4-8 Radix Glycyrrhizae Preparata 4-8
2. medicine according to claim 1 is characterized in that optimum weight part proportioning of this pharmaceutical formulation is:
Radix Angelicae Sinensis 10 Rhizoma Chuanxiongs 10 Flos Carthamis 10 Herba Leonuris 15
Pollen Typhae 10 Oletum Trogopteroris 10 Fructus Aurantiis 10 Herba Artemisiae Anomalaes 10
Rhizoma Zingiberis Preparatum 5 Radix Glycyrrhizae Preparatas 5
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN97116450A CN1062178C (en) | 1997-09-18 | 1997-09-18 | Medicine for preventing and curing bleeding side reaction after abortion by drug |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN97116450A CN1062178C (en) | 1997-09-18 | 1997-09-18 | Medicine for preventing and curing bleeding side reaction after abortion by drug |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| CN1211436A true CN1211436A (en) | 1999-03-24 |
| CN1062178C CN1062178C (en) | 2001-02-21 |
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| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN97116450A Expired - Fee Related CN1062178C (en) | 1997-09-18 | 1997-09-18 | Medicine for preventing and curing bleeding side reaction after abortion by drug |
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| CN (1) | CN1062178C (en) |
Cited By (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN100375628C (en) * | 2006-04-28 | 2008-03-19 | 四川宝光药业股份有限公司 | A medicine for treating vaginal bleeding caused by drug induced abortion and method for preparing the same |
| CN100387274C (en) * | 2005-10-08 | 2008-05-14 | 徐本荣 | Chinese medicine for treating postpartum continuous lochia, incomplete miscarriage, menstrual pain |
| CN1994366B (en) * | 2006-12-30 | 2010-12-22 | 陕西海天制药有限公司 | Chinese medicinal formulation for treating gynecological disease and preparation process thereof |
| CN102671179A (en) * | 2012-06-08 | 2012-09-19 | 山东省医学科学院基础医学研究所 | Traditional Chinese medicine for treating post-abortion metrorrhagia and preparation method thereof |
| CN103638511A (en) * | 2013-12-22 | 2014-03-19 | 林凡友 | Postpartum stasis removing particles |
Family Cites Families (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1089161A (en) * | 1993-01-01 | 1994-07-13 | 殷劲 | " Wutongfenmianling "-medicine for painless childbirth |
| CN1137904A (en) * | 1995-06-15 | 1996-12-18 | 郑洪斌 | Yikang Zhixue soluble granules |
-
1997
- 1997-09-18 CN CN97116450A patent/CN1062178C/en not_active Expired - Fee Related
Cited By (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN100387274C (en) * | 2005-10-08 | 2008-05-14 | 徐本荣 | Chinese medicine for treating postpartum continuous lochia, incomplete miscarriage, menstrual pain |
| CN100375628C (en) * | 2006-04-28 | 2008-03-19 | 四川宝光药业股份有限公司 | A medicine for treating vaginal bleeding caused by drug induced abortion and method for preparing the same |
| CN1994366B (en) * | 2006-12-30 | 2010-12-22 | 陕西海天制药有限公司 | Chinese medicinal formulation for treating gynecological disease and preparation process thereof |
| CN102671179A (en) * | 2012-06-08 | 2012-09-19 | 山东省医学科学院基础医学研究所 | Traditional Chinese medicine for treating post-abortion metrorrhagia and preparation method thereof |
| CN103638511A (en) * | 2013-12-22 | 2014-03-19 | 林凡友 | Postpartum stasis removing particles |
| CN103638511B (en) * | 2013-12-22 | 2015-08-19 | 翔宇药业股份有限公司 | Puerperal blood clot dispersing granule |
Also Published As
| Publication number | Publication date |
|---|---|
| CN1062178C (en) | 2001-02-21 |
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