CN1984670A - 治疗阿尔茨海默病的环孢菌素 - Google Patents

治疗阿尔茨海默病的环孢菌素 Download PDF

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Publication number
CN1984670A
CN1984670A CNA2005800237213A CN200580023721A CN1984670A CN 1984670 A CN1984670 A CN 1984670A CN A2005800237213 A CNA2005800237213 A CN A2005800237213A CN 200580023721 A CN200580023721 A CN 200580023721A CN 1984670 A CN1984670 A CN 1984670A
Authority
CN
China
Prior art keywords
ciclosporin
meleu
hydroxyl
cyclosporin
cell
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Pending
Application number
CNA2005800237213A
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English (en)
Chinese (zh)
Inventor
D·科恩
L·A·该赛
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Novartis AG
Original Assignee
Novartis AG
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Novartis AG filed Critical Novartis AG
Publication of CN1984670A publication Critical patent/CN1984670A/zh
Pending legal-status Critical Current

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K7/00—Peptides having 5 to 20 amino acids in a fully defined sequence; Derivatives thereof
    • C07K7/64—Cyclic peptides containing only normal peptide links
    • C07K7/645—Cyclosporins; Related peptides
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/04—Peptides having up to 20 amino acids in a fully defined sequence; Derivatives thereof
    • A61K38/12—Cyclic peptides, e.g. bacitracins; Polymyxins; Gramicidins S, C; Tyrocidins A, B or C
    • A61K38/13—Cyclosporins
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
    • A61P25/16—Anti-Parkinson drugs
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Psychology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Immunology (AREA)
  • Epidemiology (AREA)
  • Biochemistry (AREA)
  • Genetics & Genomics (AREA)
  • Molecular Biology (AREA)
  • Biophysics (AREA)
  • Hospice & Palliative Care (AREA)
  • Psychiatry (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Peptides Or Proteins (AREA)
CNA2005800237213A 2004-07-13 2005-07-12 治疗阿尔茨海默病的环孢菌素 Pending CN1984670A (zh)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US58777004P 2004-07-13 2004-07-13
US60/587,770 2004-07-13

Publications (1)

Publication Number Publication Date
CN1984670A true CN1984670A (zh) 2007-06-20

Family

ID=35276396

Family Applications (1)

Application Number Title Priority Date Filing Date
CNA2005800237213A Pending CN1984670A (zh) 2004-07-13 2005-07-12 治疗阿尔茨海默病的环孢菌素

Country Status (10)

Country Link
EP (1) EP1893226A1 (es)
JP (1) JP2008512351A (es)
KR (1) KR20070036127A (es)
CN (1) CN1984670A (es)
AU (2) AU2005261838A1 (es)
BR (1) BRPI0513317A (es)
CA (1) CA2573400A1 (es)
MX (1) MX2007000502A (es)
RU (1) RU2007105141A (es)
WO (1) WO2006005580A1 (es)

Cited By (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN102083852A (zh) * 2008-06-06 2011-06-01 西尼克斯公司 环孢菌素类似物及其在治疗hcv感染中的应用
CN102586121A (zh) * 2012-02-21 2012-07-18 淮海工学院 一种产乙酰胆碱酯酶抑制剂的真菌及其用途
CN102869367A (zh) * 2009-12-09 2013-01-09 西尼克斯公司 新颖的环肽
CN104870007A (zh) * 2012-10-19 2015-08-26 西尼克斯公司 新的抗病毒大环化合物
CN106620648A (zh) * 2016-12-30 2017-05-10 山东景源生物科技有限公司 一种阻断帕金森患者淋巴细胞周期的药物及制备方法

Families Citing this family (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP5322647B2 (ja) 2005-09-30 2013-10-23 スシネキス インク ウイルス感染の治療及び予防のためのシクロスポリンａのアリールアルキル及びヘテロアリールアルキル誘導体
US7696165B2 (en) 2006-03-28 2010-04-13 Albany Molecular Research, Inc. Use of cyclosporin alkyne analogues for preventing or treating viral-induced disorders
US7696166B2 (en) 2006-03-28 2010-04-13 Albany Molecular Research, Inc. Use of cyclosporin alkyne/alkene analogues for preventing or treating viral-induced disorders
ATE502633T1 (de) 2006-05-19 2011-04-15 Scynexis Inc Cyclosporins zur behandlung und vorbeugung von augenerkrankungen
FR2913886B1 (fr) 2007-03-22 2012-03-02 Guerbet Sa Utilisation de nanoparticules metalliques dans le diagnostique de la maladie d'alzheimer
US20100291074A1 (en) * 2007-07-27 2010-11-18 Columbia University In The City Of New York Cyclophilin d-amyloid beta interaction potentiates mitochondrial dysfunction in a transgenic mouse model of alzheimer's disease
US20090306033A1 (en) * 2008-06-06 2009-12-10 Keqiang Li Novel cyclic peptides
AU2009334790B2 (en) 2008-12-31 2016-09-08 Scynexis, Inc. Derivatives of cyclosporin A
KR20120035622A (ko) * 2010-10-06 2012-04-16 서울대학교산학협력단 Ｖｄａｃ1 단백질 조절을 통한 파킨슨씨병 치료방법
EP2900684A2 (en) 2012-09-29 2015-08-05 Novartis AG Cyclic peptides and use as medicines

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0484281B2 (en) * 1990-11-02 2000-11-22 Novartis AG Cyclosporins
JP3089350B2 (ja) * 1995-11-20 2000-09-18 ギルフォード ファーマシューティカルズ インコーポレイテッド シクロフィリンロタマーゼ活性の阻害剤
US20030103959A1 (en) * 2001-06-22 2003-06-05 Hughes Paul E. Methods of providing neuroprotection and/or neurorestoration via the neural activin type IIB receptor

Cited By (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN102083852A (zh) * 2008-06-06 2011-06-01 西尼克斯公司 环孢菌素类似物及其在治疗hcv感染中的应用
CN102869367A (zh) * 2009-12-09 2013-01-09 西尼克斯公司 新颖的环肽
CN102586121A (zh) * 2012-02-21 2012-07-18 淮海工学院 一种产乙酰胆碱酯酶抑制剂的真菌及其用途
CN102586121B (zh) * 2012-02-21 2013-07-10 淮海工学院 一种产乙酰胆碱酯酶抑制剂的真菌及其用途
CN104870007A (zh) * 2012-10-19 2015-08-26 西尼克斯公司 新的抗病毒大环化合物
CN106620648A (zh) * 2016-12-30 2017-05-10 山东景源生物科技有限公司 一种阻断帕金森患者淋巴细胞周期的药物及制备方法

Also Published As

Publication number Publication date
CA2573400A1 (en) 2006-01-19
RU2007105141A (ru) 2008-08-20
WO2006005580A1 (en) 2006-01-19
AU2009210375A1 (en) 2009-09-10
AU2005261838A1 (en) 2006-01-19
EP1893226A1 (en) 2008-03-05
KR20070036127A (ko) 2007-04-02
BRPI0513317A (pt) 2008-05-06
JP2008512351A (ja) 2008-04-24
MX2007000502A (es) 2007-03-08

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C06 Publication
PB01 Publication
C10 Entry into substantive examination
SE01 Entry into force of request for substantive examination
C02 Deemed withdrawal of patent application after publication (patent law 2001)
WD01 Invention patent application deemed withdrawn after publication

Open date: 20070620