CN1981839A - Medicine for treating diabetes and its production - Google Patents
Medicine for treating diabetes and its production Download PDFInfo
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- CN1981839A CN1981839A CN 200510130397 CN200510130397A CN1981839A CN 1981839 A CN1981839 A CN 1981839A CN 200510130397 CN200510130397 CN 200510130397 CN 200510130397 A CN200510130397 A CN 200510130397A CN 1981839 A CN1981839 A CN 1981839A
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Abstract
A Chinese medicine in the form of milk or powder for treating diabetes is prepared from 10 Chinese-medicinal materials including soybean, black bean, haw, wolfberry fruit, etc through respective washing, immersing, grinding to obtain milk, freeze-drying or drying in the air, pulverizing, proportional mixing, heating, and sterilizing.
Description
Technical field
The present invention relates to a kind of medicine for the treatment of diabetes, is the Chinese patent medicine of feedstock production with fruit and Chinese herbal medicine specifically, the invention still further relates to the preparation method of this medicine.
Background technology
Diabetes are common frdquently encountered diseases of serious harm human health, and diabetics surpasses 100,000,000 people in the world at present, and China is near 2,000 ten thousand, and the trend that increases is year by year arranged.Case fatality rate is only second to malignant tumor and cardiovascular diseases, is to jeopardize the third-largest disease of human life.
Diabetes do not heal all the life, and complication extensively and seriously.Because insulin lacks relatively or definitely in the blood, causes sugar, fat, protein metabolism disorder, causes hyperglycemia, the rising of hyperlipidemia and blood viscosity, extensively microangiopathies of the whole body appears in middle and advanced stage.Wherein 70-80% patient dies from the cardiovascular diseases, and diabetes kidney function failure and cerebrovascular accident are the common causes of death of middle and elderly diabetic patient.
Both at home and abroad to the primary disease Drug therapy, run into following thorny problem at present;
1, the biguanide drug curative effect is low, and side effect is big, for a long time with producing hyperlactacidemia.
2, iodine ureas medicine is for a long time with damaging liver, kidney and hemocyte and yellow amine medicine cross allergy, later stage generation secondary failure.
3, insulin is comforted body with producing for a long time, and biological activity reduces, and dosage increases, and produces hyperinsulinemia, impels microangiopathy to take place and development.
Though the Chinese patent medicine of some treatment diabetes is also arranged, because effect is not fairly obvious, the patient still has to rely on some Western medicine, as insulin.And must sugaring just can impel the disintegrate of medicine grain in the electuary of common Chinese patent medicine, and then containing Mel in the close ball, these dosage forms all are not suitable for diabetics and use.
Summary of the invention
The object of the present invention is to provide a kind ofly to have blood sugar lowering, blood fat reducing, improve high blood coagulation state, the mediation microcirculation strengthens the body immunity, reduces the therapeutic agent of diabetes-alleviating complication effect.
Another object of the present invention provides the preparation method of this Remedies for diabetes.
Solution of the present invention is based on motherland's medical science to diabetes and pathogenetic understanding of complication and Therapeutic Principle, achieve with reference to modern pharmacological research, from motherland's medicine treasure-house, filter out nourishing kidney-yin, QI invigorating void, change congestion, pure and impure letting out, the body resistance strengthening and constitution consolidating, the homologous natural edible-plant fruit extract of medicated diet, by the theory of Chinese medical science prescription, skim the cream off milk, make its performance promote endogenous secretion of insulin, reduce exogenous insulin periphery drag, increase biological activity, promote the metabolism of sugar, reduce fatty egg and decompose from matter, make blood glucose, blood fat reduces, microcirculation improvement, reduce, the effect of diabetes-alleviating patient cardiovascular pathological changes development
Medicine of the present invention is made by following component: (consumption is a weight portion)
Semen Glycines: 8-20; Teata glycinis 15-32; Semen Ormosiae Hosiei 8-18; Small white bean 8-15; Semen phaseoli radiati 5-16; Semen Pisi sativi 9-20; Fructus Crataegi 10-25; Peanut bean 11-24; Fructus Lycii 10-18; Semen Juglandis 10-25.
Formula optimization weight (part) ratio range of preparation medicine of the present invention is:
Semen Glycines: 12-18; Teata glycinis 18-25; Semen Ormosiae Hosiei 18-30; Small white bean 10-12; Semen phaseoli radiati 8-14; Semen Pisi sativi 11-18; Fructus Crataegi 16-22; Peanut bean 14-20; Fructus Lycii 11-16; Semen Juglandis 15-24.
The optimum weight of medicine of the present invention (part) proportioning is:
Semen Glycines: 18; Teata glycinis 25; Semen Ormosiae Hosiei 30; Small white bean 17; Semen phaseoli radiati 15; Semen Pisi sativi 16; Fructus Crataegi 20; Peanut bean 19; Fructus Lycii 15; Semen Juglandis 20.
Above-mentioned each component is made medicine production method of the present invention is:
1, after elder generation cleans up Fructus Crataegi, Fructus Crataegi pelletizing shape, the dried immersion of Fructus Lycii after will cleaning again back discards by component prescription mixed defibrination juice with the Fructus Crataegi grain and looks into the extraction medicinal liquid, then remaining Semen Glycines, teata glycinis, Semen Ormosiae Hosiei, small white bean, Semen phaseoli radiati, Semen Pisi sativi, peanut bean, Semen Juglandis are cleaned immersion after 10 hours by set of dispense than mixing, wear into serosity, then with behind all slurry agent component mix homogeneously, under 100-110 ℃ of temperature, medicament is boiled, be incubated ripening in 15-30 minute sterilization and make slurry agent product.Perhaps Fructus Crataegi, Fructus Lycii are cleaned the back and after-14 ℃ of following lyophilizations, be ground into 120 order fineness; Getting yellow Semen Phaseoli, teata glycinis, Semen Ormosiae Hosiei, small white bean, Semen phaseoli radiati, Semen Pisi sativi, peanut bean, Semen Juglandis cleans and is ground into 120 order fine powders after air-dry; Above-mentioned whole powder components by after the described mixed, are carried out the ripening sterilization under 100-110 ℃ of temperature.Temperature is raised to 110 ℃ rapidly, and segmentation thereafter drops to 100 ℃, and the ripening sterilization time is 15-30 minute.
Slurry agent or powder after the maturation process, and, can get liquid preparation or powderous preparations slurry agent vacuum packaging or with the dry final vacuum packing of powder.
An important feature of the present invention is to contain rich nutrient contents in the medicament, and wherein plant high-quality high protein content reaches 20%-30%, exceeds 32 times than rice, exceeds 2-3 doubly than lean meat, is 8-12 times of milk.And contain 13 seed amino acids, comprise lysine, glutamic acid, arginine, aspartic acid, leucine, serine, proline, valine, methionine, glycine, alanine, threonine and tyrosine, wherein lysine reaches 1648.2mg/100g, arginine reaches 963.3mg/100g, leucine reaches 1119mg/100g, the aminoacid of needed by human totally can promote the release, particularly arginine of insulin, and lysine and leucic effect are the strongest.Each amino acid composition content sees the following form in the medicine of the present invention:
| Title | Content mg/100g | Title | Content mg/100g | Title | Content mg/100g |
| Lysine | 1648.2 | Glutamic acid | 1559.9 | Arginine | 986.3 |
| Aspartic acid | 1214.3 | Leucine | 1217.0 | Serine | 648.6 |
| Proline | 511.8 | Valine | 729.9 | Methionine | 384.8 |
| Glycine | 398.3 | Alanine | 872.8 | Threonine | 451.2 |
| Tyrosine | 358.8 |
Also contain various trace elements such as calcium, phosphorus, zinc, ferrum, selenium, chromium, fluorine, potassium in addition in Remedies for diabetes of the present invention, these metallic elements are the prothetic groups that constitute the multiple metalloenzyme of body, to the biosynthesis of insulin and discharged catalytic action.The no cellulose content of each chemistry sees the following form in the medicine of the present invention:
| Title | Content mg/100g | Title | Content mg/100g | Title | Content mg/100g |
| Calcium | 1678.8 | Phosphorus | 1561 | Zinc | 27.81 |
| Ferrum | 268.4 | Potassium | 946.6 | Chromium | 22.92 |
| Fluorine | 1156.1 | Selenium | 0.2 |
Another important feature of the present invention is to contain abundant water-soluble cellulose and anthraquinone compounds in the medicament, and content of cellulose reaches 10%-20%, can promote gastrointestinal emptying, reduces sugar, fat absorption, helps blood glucose and reduces.Also contain abundant soyasaponins, choline material and flavone compound in this medicament, flavonoid content 2%-2.5% wherein, flavone compound can blood fat reducing, reduce blood viscosity, promote microcirculation, increase the islets of langerhans blood perfusion, help the synthetic and secretion of insulin.
Another important function of the present invention is not contain cholesterol in the medicament, contains abundant unsaturated fatty acid, and unsaturated fatty acid has cholesterol reducing and the sclerosis of anti-stop fat, cerebral hemorrhage and thrombotic effect.Also containing abundant lecithin in this medicament, is the brain cell important component, and very strong brain effect is arranged, and preventing the decline of memory of elderly person power and improving each age man memory power has good effect.
Clinical drug of the present invention uses the result to show that following advantage is arranged:
1, to select the homologous natural edible-plant fruit of medicated diet medicine for use be raw material in the present invention, and each component meets the pharmaceutical control law regulation.Utilize the comprehensive function of the Chinese medicine of respectively the distinguishing the flavor of bran urine of curing the disease sick, do not have chemical sweeting agent, nontoxic to human body.
2, the present invention need not decoct, and heating gets final product, no bitterness sense, and nutritious, famine is then eaten, and then drinks yearningly, and taking convenience meets state food sanitation method regulation.
3, light disease person can be independent.Can use with other antidiabetic drugs and insulin combination than severe disease disease but can significantly reduce, the use amount of antidiabetic drug and insulin usually, therapeutic effect obviously increases, and can alleviate or eliminate other complication significantly, strengthens the immunity of human body.
4, the person that is combined the hyperlipidemia, the present invention can replace per 100 348 yuan of expensive import lipid lowerers (fenofibrate), to middle and advanced stage severe diabetes patient, uses product of the present invention and can partly replace expensive antidiabetic drug (diamicron and glipizide).
For showing medicine of the present invention to the treatment of diabetes effect, the present invention is through the clinical observation of 50 routine systems, and select sick more, the state of an illness, age, sex and suitable diabetics 36 examples of former Therapeutic Method are matched group.From being in hospital and the precious case of selecting of endocrine training door, press the diabetes diagnosis standard that WHO1980 formulates, the maturity-onset diabetes patient who makes a definite diagnosis, on the basis of dietetic therapy and medicine (oral antidiabetic drug and insulin) treatment, fasting glucose 〉=7.2mm01/I person is the object of observation, wherein male 23 examples, woman's 27 examples, age 28-68 example, course of disease half a year to 30 year.Test group: on former treatment basis, the lipid lowerers of stopping using is obeyed medicine of the present invention.Matched group; Blood sugar lowering routinely, the blood fat reducing treatment is wherein fallen grain medicine, kind usage and dosage and test and is complementary, lipid lowerers employing import fenofibrate.Adopt same procedure to make regular check on fasting glucose and blood fat, three months observation periods, one month is a course of treatment, totally three courses of treatment.
Instructions of taking: 100 grams-200 grams/time, day clothes 2 times, sooner or later each once, ante cibum, boiled water was washed clothes or heating drink-service open.Clinical test results such as table 1, table 2.
As can be seen from Table 1, the fasting glucose concentration are similar substantially with the hypoglycemic medicine consumption before two groups of tests, P＞0.05, and test group is taken the present invention and is starched that blood glucose descends behind agent or the electuary, and the blood sugar lowering dose is all than original minimizing 1/3-1/2.
Table 1 is taken medicine of the present invention front and back insulin, diamicron consumption and change of blood sugar
| Case load | Insulin dosage (u/d) | Diamicron consumption (mg/d) | Fasting glucose decline (mmOl/L) | ||||
| Before | After | Before | After | Before | After | ||
| Test group | 50 | ?46.3 | ?20.69 | ?260 | ?60 | ?11.8±3.79 | ?7.86±2.31 |
| Matched group | 36 | ?45.88 | ?49.08 | ?240 | ?280 | ?11.47±3.18 | ?9.89±3.01 |
| ?t | ?0.29 | ?10.88 | ?0.27 | ?8.75 | ?0.53 | ?2.45 | |
| ?p | ＞0.05 | ＜0.01 | ＞0.05 | ＜0.01 | ＞0.05 | ＜0.01 | |
Table 2 is taken medicine front and back lipid lowerers consumption of the present invention and the average concentration change of blood fat
| Case load | Insulin dosage (u/d) | Diamicron consumption (mg/d) | Fasting glucose decline (mmOl/L) | ||||
| Before | After | Before | After | Before | After | ||
| Test group | 41 | ?0 | ?0 | ?5.73±1.10 | ?4.73±0.83 | ?2.13±1.08 | ?1.43±0.52 |
| Matched group | 27 | ?300 | ?300 | ?5.88±1.06 | ?5.13±0.97 | ?2.09±0.92 | ?2.01±0.31 |
| t | ?0.84 | ?4.32 | ?0.76 | ?3.66 | |||
| p | ?＞0.05 | ?＜0.05 | ?＞0.05 | ?＜0.05 | |||
Table 2 data show, serum forms sterin and the triglyceride mean concentration does not all have significant difference gradually before two groups of tests, but after test group takes medicine of the present invention, do not use any other lipid lowerers, can reach the purpose of blood fat reducing.
We have also measured the relevant data of test diabetic to take medicine of the present invention front and back body immune functions, and compare with the normal person, the results are shown in Table.
Table 3T Lymphocyte Subsets Determination result
| The example number | ?OKT(％) | ?OKT 4(％) | ?OKT 3(％) | ?OKT 4OKT 3 | ||
| Test value | Before the treatment | 3 | ?64.48±6.14 | ?37.48±4.28 | ?31.48±3.68 | ?1.27±0.14 |
| After the treatment | 23 | ?64.36±7.21 | ?38.91±4.11 | ?26.57±4.31 | ?1.43±0.33 | |
| Matched group | 15 | ?64.34±8.71 | ?38.91±4.11 | ?25.42±4.16 | ?1.46±0.24 | |
The detection method of T cell subsets is to adopt conventional alkaline phosphorus enzyme alkali resistance phosphoric acid enzyme process.Determination data shows, diabetics is higher than normal person, OKT significantly taking behind the OK before the medicine of the present invention
4/ OKT
3Ratio obviously reduces, and takes after the medicine of the present invention, and the two all roughly recovers normal, shows that medicine of the present invention can increase body immune function.Test statistics shows: with medicament of the present invention 50 diabeticss are done therapeutic test, that obtains significant curative effect accounts for 55%, and it effectively accounts for 42%, and invalid accounts for 3%, and total effective rate reaches 97%.
The specific embodiment
Embodiment
Take by weighing raw material (kilogram) by following proportioning:
Semen Glycines 15, teata glycinis 26, Semen Ormosiae Hosiei 30, small white bean 16, Semen phaseoli radiati 12, Semen Pisi sativi 14, Fructus Crataegi 18, peanut bean 17, Fructus Lycii 17, Semen Juglandis 18.
Production method is as follows:
Earlier Fructus Crataegi is cleaned up the back Fructus Crataegi pelletizing shape, after doing and soak, Fructus Lycii after will cleaning again discards the residual extraction medicinal liquid of looking into by component prescription mixed defibrination with the Fructus Crataegi grain, then remaining Semen Glycines, teata glycinis, Semen Ormosiae Hosiei, small white bean, Semen phaseoli radiati, Semen Pisi sativi, peanut bean, Semen Juglandis are cleaned immersion after 10 hours by set of dispense than mixing, wear into serosity, after then institute's slurry agent component being mixed, under 100 ℃ of-110 ℃ of temperature, medicament is boiled Buddhist, be incubated ripening in 15-25 minute sterilization and make the serosity medicament.Or with Fructus Crataegi, Fructus Lycii is cleaned the back and be ground into 120 order fineness after-14 ℃ of following lyophilization; Getting Semen Glycines, teata glycinis, Semen Ormosiae Hosiei, small white bean, Semen phaseoli radiati, Semen Pisi sativi, peanut bean, Semen Juglandis cleans and is ground into 120 order fine powders after air-dry; Above-mentioned whole fine powder components by after the described mixed, 110 ℃ of insulations 15 minutes down, are cooled to 105 ℃ of insulations 10 minutes then, be cooled to 100 ℃ of insulations minute again, carry out the ripening sterilization, make powder.
Claims (8)
1. a medicine for the treatment of diabetes is characterized in that, it is the medicament of being made by the following weight proportion raw material:
Semen Glycines 8-20, teata glycinis 15-26, Semen Ormosiae Hosiei 15-32, small white bean 8-18, Semen phaseoli radiati 5-16, Semen Pisi sativi 9-20, Fructus Crataegi 10-25, Semen arachidis hypogaeae 11-24, Fructus Lycii 10-18, Semen Juglandis 10-25.
2. the medicine of treatment diabetes according to claim 1 is characterized in that, wherein the weight proportion of each raw material is:
Semen Glycines 12-18, teata glycinis 18-25, Semen Ormosiae Hosiei 18-30, small white bean 10-12, Semen phaseoli radiati 8-14, Semen Pisi sativi 11-18, Fructus Crataegi 16-22, Semen arachidis hypogaeae 14-20, Fructus Lycii 11-16, Semen Juglandis 20.
3. the medicine of treatment diabetes according to claim 1 is characterized in that, wherein the weight proportion of each raw material is:
Semen Glycines 18, teata glycinis 25, Semen Ormosiae Hosiei 30, small white bean 17, Semen phaseoli radiati 15, Semen Pisi sativi 16, Fructus Crataegi 20, Semen arachidis hypogaeae 19, Fructus Lycii 15, Semen Juglandis 20.
4. according to the medicine of claim 1 or 2 or 3 described treatment diabetes, it is characterized in that described medicament is slurry agent or powder.
5. the medicine of treatment diabetes according to claim 4 is characterized in that, described medicament is slurry agent or powder.
6. the preparation method of the medicine of treatment diabetes according to claim 4, it is characterized in that, get Fructus Crataegi earlier, clean up the back Fructus Crataegi pelletizing shape, Fructus Lycii after will cleaning again soaks the back and presses component prescription mixed defibrination with the Fructus Crataegi grain, discard residue and extract medicinal liquid, then with remaining Semen Glycines, teata glycinis, Semen Ormosiae Hosiei, small white bean, Semen phaseoli radiati, Semen Pisi sativi, Semen arachidis hypogaeae, Semen Juglandis is cleaned immersion after 10 hours by set of dispense than mixing, wear into serosity, then with behind all slurry agent component mix homogeneously, under 100-110 ℃ of temperature medicament is boiled, ripening in-30 minutes sterilization makes the slurry agent to be incubated 15 minutes; Or with Fructus Crataegi bean, the clean back 120 order fineness that after-14 ℃ of following lyophilizations, are ground into of Fructus Lycii, getting Semen Glycines, teata glycinis, Semen Ormosiae Hosiei, small white bean, Semen phaseoli radiati, Semen Pisi sativi, Semen arachidis hypogaeae, Semen Juglandis cleans and is ground into 120 order fine powders after air-dry, with above-mentioned whole powder components by after the described mixed, under 100-110 ℃ of temperature, carry out ripening, sterilization treatment 15-30 minute, make powder.
7. the preparation method of the medicine of treatment diabetes according to claim 6, it is characterized in that ripening disinfecting action wherein is to adopt step type cooling ripening sterilization, and temperature is raised to 110 ℃ rapidly, segmentation drops to 100 ℃ then, and the ripening sterilization time is 15-30 minute.
8. the preparation method of the medicine of treatment diabetes according to claim 7, it is characterized in that, wherein to come bacterium operation be the serosity that will mix or fine powder 110 ℃ of insulations 15 minutes down in ripening, and then cool to 105 ℃ and kept 10 minutes, and lowering the temperature 100 ℃ kept 5 minutes again.
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| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN 200510130397 CN1981839A (en) | 2005-12-13 | 2005-12-13 | Medicine for treating diabetes and its production |
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| Application Number | Priority Date | Filing Date | Title |
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| CN 200510130397 CN1981839A (en) | 2005-12-13 | 2005-12-13 | Medicine for treating diabetes and its production |
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| CN1981839A true CN1981839A (en) | 2007-06-20 |
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Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN102334525A (en) * | 2011-09-01 | 2012-02-01 | 于秀珠 | Health-care food for reducing blood sugar |
-
2005
- 2005-12-13 CN CN 200510130397 patent/CN1981839A/en active Pending
Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN102334525A (en) * | 2011-09-01 | 2012-02-01 | 于秀珠 | Health-care food for reducing blood sugar |
| CN102334525B (en) * | 2011-09-01 | 2012-11-07 | 于秀珠 | Health-care food for reducing blood sugar |
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