CN1981764A - α-(吗啉-1-基)甲基-2-甲基-5-硝基咪唑-1-乙醇在制备抗滴虫、抗阿米巴原虫药物的用途 - Google Patents
α-(吗啉-1-基)甲基-2-甲基-5-硝基咪唑-1-乙醇在制备抗滴虫、抗阿米巴原虫药物的用途 Download PDFInfo
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化合物 | MIC(μg/ml) | |
阴道毛滴虫 | 溶组织内阿米巴原虫 | |
实施例化合物 | 0.5 | 3 |
甲硝唑 | 2.0 | 3 |
奥硝唑 | 1.0 | 6 |
化合物 | 口服ED50(mg/kg) | |
阴道毛滴虫 | 溶组织内阿米巴原虫 | |
实施例化合物 | 10 | 8 |
甲硝唑 | 20 | 25 |
奥硝唑 | 35 | 10 |
化合物 | 口服2000mg/kg死亡率(%) | 腹腔注射2000mg/kg死亡率(%) |
实施例化合物 | 0 | 0 |
甲硝唑 | 30 | 40 |
奥硝唑 | 50 | 70 |
Claims (6)
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CNB2005101342543A CN100427094C (zh) | 2005-12-13 | 2005-12-13 | α-(吗啉-1-基)甲基-2-甲基-5-硝基咪唑-1-乙醇在制备抗滴虫、抗阿米巴原虫药物的用途 |
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CNB2005101342543A CN100427094C (zh) | 2005-12-13 | 2005-12-13 | α-(吗啉-1-基)甲基-2-甲基-5-硝基咪唑-1-乙醇在制备抗滴虫、抗阿米巴原虫药物的用途 |
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CN1981764A true CN1981764A (zh) | 2007-06-20 |
CN100427094C CN100427094C (zh) | 2008-10-22 |
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Cited By (5)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN104628651A (zh) * | 2013-11-06 | 2015-05-20 | 江苏豪森药业股份有限公司 | 吗啉硝唑异构体及其制备方法 |
CN104829541A (zh) * | 2015-05-05 | 2015-08-12 | 江苏豪森药业股份有限公司 | 高选择性及高纯度制备吗啉硝唑的方法 |
CN104844522A (zh) * | 2015-05-05 | 2015-08-19 | 江苏豪森药业股份有限公司 | 吗啉硝唑晶体及其制备方法和医药用途 |
CN107556304A (zh) * | 2016-06-30 | 2018-01-09 | 陕西合成药业股份有限公司 | 一种新型硝基咪唑类药物及其制备方法和用途 |
CN114907250A (zh) * | 2021-02-06 | 2022-08-16 | 华创合成制药股份有限公司 | 一种氘代吗啉硝唑及其用途 |
Family Cites Families (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN1179951C (zh) * | 2002-07-19 | 2004-12-15 | 中国科学院上海有机化学研究所 | 噻克硝唑的光学对映体、制备方法及其用途 |
CN100344626C (zh) * | 2003-10-08 | 2007-10-24 | 连云港恒邦医药科技有限公司 | α-(吗啉-1-基)甲基-2-甲基-5-硝基咪唑-1-乙醇用于制备抗厌氧菌药物的用途 |
-
2005
- 2005-12-13 CN CNB2005101342543A patent/CN100427094C/zh active Active
Cited By (8)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN104628651A (zh) * | 2013-11-06 | 2015-05-20 | 江苏豪森药业股份有限公司 | 吗啉硝唑异构体及其制备方法 |
CN104628651B (zh) * | 2013-11-06 | 2018-07-24 | 江苏豪森药业集团有限公司 | 吗啉硝唑异构体及其制备方法 |
CN104829541A (zh) * | 2015-05-05 | 2015-08-12 | 江苏豪森药业股份有限公司 | 高选择性及高纯度制备吗啉硝唑的方法 |
CN104844522A (zh) * | 2015-05-05 | 2015-08-19 | 江苏豪森药业股份有限公司 | 吗啉硝唑晶体及其制备方法和医药用途 |
CN104844522B (zh) * | 2015-05-05 | 2017-07-25 | 江苏豪森药业集团有限公司 | 吗啉硝唑晶体及其制备方法和医药用途 |
CN107556304A (zh) * | 2016-06-30 | 2018-01-09 | 陕西合成药业股份有限公司 | 一种新型硝基咪唑类药物及其制备方法和用途 |
CN107556304B (zh) * | 2016-06-30 | 2022-06-03 | 华创合成制药股份有限公司 | 一种硝基咪唑类药物及其制备方法和用途 |
CN114907250A (zh) * | 2021-02-06 | 2022-08-16 | 华创合成制药股份有限公司 | 一种氘代吗啉硝唑及其用途 |
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