CN1969924A - 水飞蓟宾和板蓝根的药物组合物 - Google Patents
水飞蓟宾和板蓝根的药物组合物 Download PDFInfo
- Publication number
- CN1969924A CN1969924A CNA2006101491896A CN200610149189A CN1969924A CN 1969924 A CN1969924 A CN 1969924A CN A2006101491896 A CNA2006101491896 A CN A2006101491896A CN 200610149189 A CN200610149189 A CN 200610149189A CN 1969924 A CN1969924 A CN 1969924A
- Authority
- CN
- China
- Prior art keywords
- radix isatidis
- group
- parts
- extract
- silibinin
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
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Abstract
Description
组别 | 重量份数 | 给药剂量(g/kg) | ALT(IU/L) | AST(IU/L) |
正常对照组CCl4造模组板蓝根组水飞蓟宾葡甲胺组SHB组(水飞蓟宾葡甲胺+板蓝根) | ----400+200200+200100+200100+500100+100050+1000200+8000100+8000100+15000100+2000050+2000025+20000 | --1.00.051.01.01.01.01.01.01.01.01.01.01.01.0 | 24.42±2.852800.54±3 14.26##2154.46±347.51*1408.69±123.46**859.15±110.54**802.25±119.36**746.32±117.54**627.57±156.48**556.89±112.42**561.69±117.54**559.59±114.27**555.91±119.21**629.17±108.69**718.36±119.64**797.26±132.71**836.55±124.57** | 401.77±30.125059.38±452.74##303 1.79±245.84*2037.85±1 85.63**1889.18±163.74**1802.48±143.25**1798.54±120.68**1756.48±149.68**1669.78±126.59**1682.33±125.48**1686.26±132.51**1679.39±124.94**1748.94±116.15**1794.64±118.62**1813.45±111.25**1907.57±184.12** |
组别 | 重量配比 | 给药剂量(mg/kg) | LN(μg/L) | HA(μg/L) |
空白对照组模型组水飞蓟宾葡甲胺组板蓝根组SHB组(水飞蓟宾葡甲胺+板蓝根) | 400+200200+200100+200100+500100+100050+1000200+8000100+8000100+15000100+2000050+2000025+20000 | --0.0501.01.01.01.01.01.01.01.01.01.01.01.01.0 | 44.57±14.52118.45±28.19##83.54±17.82*97.15±16.24*72.78±19.24**69.54±18.21**63.94±20.34**57.18±19.48**51.77±11.12**52.31±10.69**52.94±11.34**51.45±10.98**58.64±15.74**65.87±21.96**68.94±19.64**71.20±20.18** | 128.59±20.47411.74±38.13##296.18±35.67*347.16±36.88*227.79±40.56**205.36±31.65**179.63±24.31**158.34±21.89**142.12±15.57**143.94±14.96**142.69±15.05**143.54±15.01**159.87±15.29**193.78±26.49**183.63±27.64**194.75±32.61** |
组别 | 重量配比 | 给药剂量(mg/kg) | SGPT(u/dl) | LTG(mg/g) | MDA(nmol/g) |
空白对照组CCl4对照组水飞蓟宾葡甲胺板蓝根提取物组SHB组合物注射液组(水飞蓟宾葡甲胺+板蓝根提取物) | ----50mg+5mg50mg+10mg100mg+5mg100mg+10mg100mg+15mg100mg+20mg150mg+20mg200mg+20mg | -1015151515151515151515 | 243±51609±247**538±199*#541±202*#256±60##&△314±123##&△266±84##&△241±52##&△267±58##&△276±80##&△288±91##&△250±55##&△ | 13±734±14**27±8*#29±9*#13±6##&△18±5##&△15±3##&△12±3##&△14±2##&△16±4##&△18±6##&△13±4##&△ | 44±1081±25**65±20*#63±18*#38±8##&△47±11##&△42±9##&△36±6##&△41±7##&△45±10##&△48±11##&△40±8##&△ |
组别 | 动物数(只) | 给药剂量(mg/kg) | 肝指数(g/100g) | 脾指数(g/100g) |
空白对照组CCl4对照组水飞蓟宾葡甲胺组板蓝根提取物组SHB组合物注射液组(低剂量)SHB组合物注射液组(中剂量)SHB组合物注射液组(高剂量) | 10101010101010 | -10151551015 | 6.24±1.018.46±0.65**7.44±0.78*#7.53±0.75*#6.65±0.80##&△6.56±0.76##&△6.33±0.78##&△ | 0.629±0.1450.721±0.082**0.684±0.047*#0.691±0.046*#0.653±0.056##&△0.638±0.052##&△0.628±0.047##&△ |
组别 | 给药剂量(mg/kg) | SGPT(u/dl) | SGST(nmol·min·ml-1) | GSH(mmol/g肝) |
空白对照组AP对照组水飞蓟宾葡甲胺组板蓝根提取物组SHB组合物组(低剂量)SHB组合物组(中剂量)SHB组合物组(高剂量) | -1001530102030 | 185±35702±310**394±206*#435±214*#289±171##&△267±165##&△237±159#&△ | 119±29489±233**234±165*#298±171*#171±86##&△164±79##&△153±72##&△ | 4.5±1.52.6±1.0**3.9±1.2*#3.2±1.2*#4.2±1.7##&△4.7±1.6##&△5.2±1.7##&△ |
组别 | 给药剂量mg/kg | 治疗前DHBV-DNA滴度 | 治疗后7dDHBV-DNA滴度 | 治疗后14dDHBV-DNA滴度 | 停药后3dDHBV-DNA滴度 |
空白对照组阳性对照组水飞蓟宾葡甲胺组板蓝根提取物组SHB组合物低剂量组SHB组合物中剂量组SHB组合物高剂量组 | -50151551015 | 1.63±0.071.62±0.031.63±0.051.61±0.031.58±0.041.59±0.031.62±0.05 | 1.62±0.050.76±0.15**&&1.29±0.07*&1.32±0.06*&1.0l±0.12**&&#△0.96±0.17**&&#△0.85±0.18**&&#△ | 1.61±0.030.81±0.13**&&1.27±0.08*&1.30±0.06*&0.99±0.09**&&#Δ0.88±0.14**&&#Δ0.80±0.15**&&#△ | 1.64±0.041.61±0.051.36±0.04*&1.40±0.03*&1.05±0.09**&&#△0.98±0.08**&&#Δ0.90±0.11**&&#Δ |
批号 | 总氮含量(%) | 得率(%) |
123平均 | 15.6716.1316.5116.10 | 1.541.311.341.40 |
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