CN1958837A - Technique for vacuum coating bottle closure of rubber - Google Patents
Technique for vacuum coating bottle closure of rubber Download PDFInfo
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- CN1958837A CN1958837A CN 200610152292 CN200610152292A CN1958837A CN 1958837 A CN1958837 A CN 1958837A CN 200610152292 CN200610152292 CN 200610152292 CN 200610152292 A CN200610152292 A CN 200610152292A CN 1958837 A CN1958837 A CN 1958837A
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Abstract
This invention discloses a process for vacuum-plating rubber stopper. The process comprises: (1) vacuum-plating integrated rubber-stopper template in a vacuum chamber; or (2) adhering a patch with holes to the plug side of the integrated rubber-stopper template to cover the part that need not be plated, and vacuum-plating the integrated rubber-stopper template in a vacuum-chamber; or (3) arraying single punched rubber stoppers on a plate to obtain combined templates, and vacuum-plating in a vacuum chamber. The process can improve the efficiency and quality of vacuum plating, thus reducing the cost of rubber stopper vacuum plating. Meanwhile, the process can simplify the operation of rubber stopper vacuum plating, and realize high-efficiency vacuum plating operation with low cost.
Description
Technical field
The invention belongs to the technical field of vacuum plating of pharmaceutical bottle closure of rubber, relate in particular to the bottle stopper of a kind of infusion medicine, drug container such as freeze-dried or medical facilities such as infusion pump, cylinder piston technique for vacuum coating with the bottle closure of rubber of plug etc.
Background technology
For prevent that medicine from being polluted and seepage in storage, transportation and use, bottle closure of rubber generally is commonly used for the sealing member of pharmaceutical product packaging, as transfusion bottle stopper, freeze-dried bottle stopper, blood test-tube plug, infusion pump plug, tooth section anesthesia cylinder piston, prepackage injection needle tube piston, insulin syringe piston and the used sealing member of various aerosol bottle (vent fan) etc.Medicine after the bottle stopper packing, in depositing process the infiltration of gas and water vapour very harmful, it is the major cause that causes medicine mouldy and rotten, the air transmission coefficient of isoprene-isobutylene rubber is 1/20 of a natural rubber.China has progressively passed through the application dynamics that multinomial notice advances butyl rubber plug again after having assigned " No. the 8th, traditional Chinese medicines matter word (95) is about eliminating the notice of part natural rubber microbiotic bottle cap " in nineteen ninety-five by former State Pharmaceutical Administration.
But the butyl bottle closure of rubber is used in transfusion and is also had many problems: the one, there is the problem of particulate matter in the transfusion; The 2nd, there is the problem of puncture exfoliation in butyl rubber bottle stopper; The 3rd, there are quality problems in the isoprene-isobutylene rubber raw material.In order to address the above problem, China is continuous mutually have been occurred filming and the plated film butyl rubber bottle stopper.By butyl rubber bottle stopper being carried out part or all of plated film or filming, can solve the adsorption and diffusion extracting problem between bottle closure of rubber surface and soup; Plug behind the plated film does not re-use silicone oil, can thoroughly stop problem of silicone oil particle contamination soup or the like.The plated film bottle stopper is mainly used in cephalosporins, aqueous injection class, biological drug and some therapeutic type infusion medicine at present.Medicine newly developed to some, that added value is higher is generally also selected the plated film bottle stopper.
The rete on bottle closure of rubber surface is an inertia high molecular polymerization film, not with drug reaction, can completely cut off the precipitate and the drug reaction of bottle closure of rubber again.Parylene is widely used as Coating Materials, it adopts technique for vacuum coating, by the solid feed p-Xylol is evaporated, the vacuum film coating chamber under room temperature state carries out the polymerization deposition, is adsorbed on that polymerization becomes parylene film on the matrix moment.In order to make plated film even, generally adopt the single bottle closure of rubber that will cut to put at present and carry out plated film into vacuum film coating chamber, or be deposited in the horizontal vacuum coating chamber the bottle closure of rubber that cuts is random, under the condition that vacuum film coating chamber rolls, carry out plated film then, obtain this plated film bottle closure of rubber.Because be subjected to bottle closure of rubber discharging and stacking amount that coating effects is had certain influence, the vacuum film coating chamber cavity of existing bottle closure of rubber is less, output is also lower, can't realize the economic benefit of mass-producing.Operation easier when needing that simultaneously bottle closure of rubber carried out the part plated film is also bigger.
The research staff of plated film butyl rubber bottle stopper generally believes, shortening the plated film time under the prerequisite that improves the butyl rubber bottle stopper coating quality is the most effectual way that reduces cost, increases benefit, and will not change have filming equipment and bottle closure of rubber to be coated now mode as the breach.They do not recognize and start with from the coating process that changes existing bottle closure of rubber that effectively to increase production be the best means of boosting productivity.
Summary of the invention
The purpose of this invention is to provide the technique for vacuum coating bottle closure of rubber that a kind of technology is simple, output effectively improves, can effectively carry out vacuum plating and handle, effectively improve the productive rate of vacuum plating bottle stopper bottle closure of rubber in enormous quantities.
For achieving the above object, technical scheme provided by the invention is as follows:
A kind of technique for vacuum coating bottle closure of rubber is characterized in that, bottle closure of rubber is gathered matrix integral body put into that vacuum plating is indoor carries out vacuum plating.
A kind of technique for vacuum coating bottle closure of rubber, it is characterized in that, stick harness face at the set matrix of bottle closure of rubber attaches a paster with holes, and described paster with holes will be gathered matrix does not need the plated film position to attach, and should gather matrix then and put into vacuum film coating chamber and carry out vacuum plating.
Described paster with holes is sheet material or the sheet material that metal, plastics or matrix material are made.
The set matrix of described bottle closure of rubber is the matrix that is distributed with a plurality of bottle closure of rubber that adopts mold pressing, vulcanization process to obtain.
Above-mentioned two kinds of coating process are described bottle closure of rubber set matrix vertical hanging or level to be shelved on vacuum plating is indoor carries out vacuum plating, the set matrix adopts the bottle stopper plunger outward to carry out two and stacks the back vertical hanging or level is shelved, sidewall to vacuum film coating chamber in the vacuum plating process heats, and the temperature of inwall is remained on more than 90 ℃.
In the above-mentioned vacuum plating process, the set matrix of vertical hanging or the set matrix that level is shelved are at vacuum film coating chamber internal rotation plated film.
Another kind of technique for vacuum coating bottle closure of rubber is characterized in that, die-cut single bottle closure of rubber is placed in obtains making up matrix on the disc, and integral body puts into that vacuum plating is indoor carries out vacuum plating then.
Described bottle closure of rubber combination matrix vertical hanging or level be shelved on vacuum plating is indoor carries out vacuum plating, the combination matrix adopts the bottle stopper plunger outward to carry out two and stacks the back vertical hanging or level is shelved.
The housing of described vacuum film coating chamber is the vertical and cylindrical structure, the sidewall of housing is offered a body, housing is provided with the exhaust system that communicates with the reaction chamber inner chamber, the diameter of described housing is 0.6～3.0 meter, highly be 0.8～3.0 meter, described exhaust system is thick, thin two-way air-bleed system, slightly, being respectively equipped with opening/shutting valve on the thin extraction pipe bleeds in order to realize big conductance or restriction conductance mode, opening earlier thick extraction pipe when vacuum plating begins carries out big conductance and bleeds, close thick extraction pipe then, open thin extraction pipe realization restriction conductance mode and bleed.
In the above-mentioned vacuum plating process, the combination matrix of vertical hanging or the combination matrix that level is shelved are at vacuum film coating chamber internal rotation plated film, and the sidewall to vacuum film coating chamber in the vacuum plating process heats, and the temperature of inwall is remained on more than 90 ℃.
The technique for vacuum coating bottle closure of rubber that the present invention adopts is that the bottle stopper matrix to full wafer or combination carries out the plated film operation, the aggregate of bottle stopper matrix a plurality of bottle stopper matrixs that to be rubber sheet obtain through compacting, and matrix is not also made one bottle stopper through section.Whole matrix is carried out plated film can reduce the indoor unit of vacuum plating and take up room, can also reduce that bottle stopper is made simultaneously and plated film in operation, effectively reduce coating cost.
When if desired plated film is carried out at certain position of bottle closure of rubber, existing film coating method and filming equipment can't solve, and adopt technique for vacuum coating of the present invention to realize easily.When for example only needing stick harness to bottle stopper to carry out plated film, can attach with the stick harness face of a paster with holes the bottle stopper matrix, hole on the paster is corresponding with stick harness, so just can realize the part plated film of bottle stopper, existing technique for vacuum coating and equipment will realize that the part plated film of bottle stopper is then complicated a lot.For the single bottle closure of rubber that has cut, also can adopt bottle closure of rubber put into disc be arranged in the combination matrix form carry out the full wafer plated film, utilize this disc can carry out the plated film of partial portion or whole bottle stopper to bottle closure of rubber.Bottle closure of rubber can be to embed or be placed on the disc.
The space of existing vacuum film coating chamber is very little, all less than 0.25m
3, reason is that those skilled in the art it has been generally acknowledged that: pile up under a fairly large number of situation at one bottle stopper, can't make plated film even in the short period of time.The space enlargement of vacuum film coating chamber also can bring the plated film time to be longer than the summation of the repeatedly plated film time of little space vacuum coating chamber, also can cause the consumption rate of coating raw material to increase, and cost of manufacture improves.
For realizing above-mentioned technology, the present invention has adopted a kind of vertical and cylindrical vacuum coating film equipment, it adopts bigger vacuum plating space, the bottle closure of rubber matrix or the combination matrix that can hold a plurality of full wafers, it is indoor to be hung vertically in vacuum plating after bottle stopper matrix or combination matrix can be clamped on one side with holder, and it is indoor also can matrix or combination matrix level to be shelved on vacuum plating with horizontal strut member.For taking up room of the unit's of saving matrix, matrix adopts the bottle stopper plunger outward to carry out two and stacks the back vertical hanging or level is shelved.When adopting big volumetrical vacuum film coating chamber, be preferably in the process of plating axis of bottle stopper matrix around vacuum film coating chamber is rotated.Make the bottle closure of rubber on every matrix can both obtain uniform coatings.Matrix behind the plated film is made one plated film bottle closure of rubber through section again.In order to save the consumption of coating raw material to greatest extent, the mode of the heating sidewall that the present invention also adopts avoids coating raw material to deposit film forming on bigger vacuum plating chamber interior walls.
Beneficial effect of the present invention is that the technique for vacuum coating of this bottle closure of rubber can carry out the vacuum plating operation to the bottle stopper set matrix or the combination matrix of full wafer, effectively improves the efficient and the output of vacuum plating, thereby reduces the cost of vacuum coating bottle closure of rubber.This technology can also be simplified the operating procedure of bottle stopper part plated film simultaneously, realizes coating operation efficient, that save.
Embodiment
The invention will be further elaborated below in conjunction with embodiment and Comparative Examples.
Embodiment 1 adopts the butyl rubber bottle stopper of mould compression moulding to carry out vacuum plating, and the set matrix of this butyl rubber bottle stopper is a rectangle, horizontal bottle stopper number 30, and the bottle stopper number is 29 longitudinally, and the length of set matrix is 705mm, and width is 710mm.
The vacuum film coating chamber of employed vacuum coating film equipment is the vertical cylinder shape, and sidewall is offered a body, and the coating chamber internal diameter is 1200mm, highly is 1200m, and vacuum plating is indoor to be provided with a plurality of holders.
The stick harness of two butyl rubber bottle stoppers set matrixs is outwards stacked, clamp with holder then that to be hung vertically in vacuum plating behind the narrow limit indoor, hanging the sheet number is 60.
Carry out conventional vacuum plating operation to the indoor feeding Parylene of vacuum plating Coating Materials, elder generation's thick extraction pipe of unlatching carries out big conductance and bleeds, close thick extraction pipe then, opening thin extraction pipe realization restriction conductance mode bleeds, the muff that adds by the vacuum plating chamber outer wall carries out the heating of sidewall simultaneously, keep the temperature of sidewall to be higher than 90 ℃, the whole plated film activity duration is 10h, obtains isoprene-isobutylene rubber plated film bottle stopper at last.The plated film expense of each butyl rubber bottle stopper is about 0.05 yuan, and the plated film time is 0.684 second.
The SCS company that Comparative Examples adopts present bottle stopper manufacturing enterprise generally to adopt produces PDS-2060 type vacuum coating film equipment and carries out the operation of butyl rubber bottle stopper plated film, coating chamber bulk is 330mm * 750mm, put into one bottle closure of rubber and carry out the plated film operation, put into 2000 bottle stoppers altogether, carry out conventional vacuum plating operation to the indoor feeding Parylene of vacuum plating Coating Materials, the whole plated film activity duration is 6h, obtains isoprene-isobutylene rubber plated film bottle stopper at last.The plated film expense of each butyl rubber bottle stopper is about 0.25 yuan, and plated film process period is 10.8 seconds.
By embodiment 1 and Comparative Examples as can be seen, though it is longer to adopt technique for vacuum coating of the present invention to carry out time of single stove plated film, but the plated film time of single butyl rubber bottle stopper shortens greatly, deduction falls the productive rate that increases normal increase because of the vacuum plating space, the unit cost of the technique for vacuum coating that embodiment 1 adopts is 1/5 of an existing technology, and the while productive rate is 15.7 times of existing technology.
Embodiment 2 adopts the butyl rubber bottle stopper of mould compression moulding to carry out vacuum plating, this butyl rubber bottle stopper is the single bottle stopper that cuts, bottle stopper embeds forms the combination matrix in the disc, the combination matrix is a rectangle, horizontal bottle stopper number is 22, the bottle stopper number is 20 longitudinally, and the length of combination matrix is 630mm, and width is 630mm.
The vacuum film coating chamber of employed vacuum coating film equipment is the vertical cylinder shape, and sidewall is offered a body, and the coating chamber internal diameter is 1200mm, highly is 1200mm, and vacuum plating is indoor to be provided with a plurality of horizontal hold items.
The stick harness of two butyl rubber bottle stopper combination matrixs is outwards stacked, and level is placed on the hold item then, and the sheet number of the combination matrix of shelving is 60.
Carry out conventional vacuum plating operation to the indoor feeding Parylene of vacuum plating Coating Materials, the whole plated film activity duration is 9h, obtains isoprene-isobutylene rubber plated film bottle stopper at last.The plated film expense of each butyl rubber bottle stopper is about 0.06 yuan, and the plated film time is 1.08 seconds.
By embodiment 2 and Comparative Examples as can be seen, though it is longer to adopt technique for vacuum coating of the present invention to carry out time of plated film, the plated film time of single butyl rubber bottle stopper shortens greatly, and deduction falls because of the vacuum plating space to increase the normal productive rate that increases.
Embodiment 3 adopts the butyl rubber bottle stopper of mould compression moulding to carry out vacuum plating, this butyl rubber bottle stopper is the single bottle stopper that cuts, bottle stopper embeds forms the combination matrix in the disc, the combination matrix is a rectangle, horizontal bottle stopper number is 18, the bottle stopper number is 17 longitudinally, and the length of combination matrix is 650mm, and width is 600mm.With onesize paster with holes the part planar section of stick harness face is attached, only to the stick harness part plated film of bottle stopper.
The vacuum film coating chamber of employed vacuum coating film equipment is the vertical cylinder shape, and sidewall is offered a body, and the coating chamber internal diameter is 1200mm, highly is 1200mm, and vacuum plating is indoor to be provided with a plurality of holders.
The stick harness of two butyl rubber bottle stoppers set matrixs is outwards stacked, clamp with holder then that to be hung vertically in vacuum plating behind the narrow limit indoor, hanging the sheet number is 60.
Carry out conventional vacuum plating operation to the indoor feeding Parylene of vacuum plating Coating Materials, elder generation's thick extraction pipe of unlatching carries out big conductance and bleeds, close thick extraction pipe then, opening thin extraction pipe realization restriction conductance mode bleeds, the whole plated film activity duration is 6.5H, obtains the butyl rubber bottle stopper of part plated film at last.The plated film expense of each butyl rubber bottle stopper is about 0.06 yuan, and the plated film time is 1.26 seconds.
By the foregoing description and Comparative Examples as can be known, this technique for vacuum coating bottle closure of rubber not only has plated film operational capability efficiently, also save time at the single bottle closure of rubber of reaction indoor placement, advantage when having high yield and low cost, improve the production efficiency of existing bottle closure of rubber plated film enterprise greatly, significantly reduced the coating cost of bottle closure of rubber.
Claims (10)
1. a technique for vacuum coating bottle closure of rubber is characterized in that, bottle closure of rubber is gathered matrix integral body put into that vacuum plating is indoor carries out vacuum plating.
2. technique for vacuum coating bottle closure of rubber, it is characterized in that, stick harness face at the set matrix of bottle closure of rubber attaches a paster with holes, and described paster with holes will be gathered matrix does not need the plated film position to attach, and should gather matrix then and put into vacuum film coating chamber and carry out vacuum plating.
3. technique for vacuum coating bottle closure of rubber according to claim 2 is characterized in that, described paster with holes is sheet material or the sheet material that metal, plastics or matrix material are made.
4. technique for vacuum coating bottle closure of rubber according to claim 1 and 2, the set matrix that it is characterized in that described bottle closure of rubber are the matrixs that is distributed with a plurality of bottle closure of rubber that adopts mold pressing, vulcanization process to obtain.
5. technique for vacuum coating bottle closure of rubber according to claim 1 and 2, it is characterized in that described bottle closure of rubber set matrix vertical hanging or level be shelved on that vacuum plating is indoor carries out vacuum plating, the set matrix adopts the bottle stopper plunger outward to carry out two and stacks the back vertical hanging or level is shelved, sidewall to vacuum film coating chamber in the vacuum plating process heats, and the temperature of inwall is remained on more than 90 ℃.
6. technique for vacuum coating bottle closure of rubber according to claim 5 is characterized in that in the vacuum plating process, and the set matrix of vertical hanging or the set matrix that level is shelved are at vacuum film coating chamber internal rotation plated film.
7. a technique for vacuum coating bottle closure of rubber is characterized in that, die-cut single bottle closure of rubber is placed in obtains making up matrix on the disc, and integral body puts into that vacuum plating is indoor carries out vacuum plating then.
8. according to right 7 described technique for vacuum coating bottle closure of rubber, it is characterized in that, described bottle closure of rubber combination matrix vertical hanging or level be shelved on vacuum plating is indoor carries out vacuum plating, the combination matrix adopts the bottle stopper plunger outward to carry out two and stacks the back vertical hanging or level is shelved.
9. according to claim 1,2 or 7 described technique for vacuum coating bottle closure of rubber, the housing that it is characterized in that described vacuum film coating chamber is the vertical and cylindrical structure, the sidewall of housing is offered a body, housing is provided with the exhaust system that communicates with the reaction chamber inner chamber, the diameter of described housing is 0.6～3.0 meter, highly be 0.8～3.0 meter, described exhaust system is thick, thin two-way air-bleed system, slightly, being respectively equipped with opening/shutting valve on the thin extraction pipe bleeds in order to realize big conductance or restriction conductance mode, opening earlier thick extraction pipe when vacuum plating begins carries out big conductance and bleeds, close thick extraction pipe then, open thin extraction pipe realization restriction conductance mode and bleed.
10. according to right 8 described technique for vacuum coating bottle closure of rubber, it is characterized in that, in the vacuum plating process, the combination matrix of vertical hanging or the combination matrix that level is shelved are at vacuum film coating chamber internal rotation plated film, sidewall to vacuum film coating chamber in the vacuum plating process heats, and the temperature of inwall is remained on more than 90 ℃.
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| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN 200610152292 CN1958837A (en) | 2006-09-30 | 2006-09-30 | Technique for vacuum coating bottle closure of rubber |
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| Application Number | Priority Date | Filing Date | Title |
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| CN 200610152292 CN1958837A (en) | 2006-09-30 | 2006-09-30 | Technique for vacuum coating bottle closure of rubber |
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| CN1958837A true CN1958837A (en) | 2007-05-09 |
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Cited By (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN101427979B (en) * | 2007-11-09 | 2012-02-01 | 山东省药用玻璃股份有限公司 | Method for preparing semi-coating medical rubber plug |
| CN102743291A (en) * | 2011-04-20 | 2012-10-24 | 江苏博生医用新材料股份有限公司 | Silicone-free high elasticity coated drug bottle plug and manufacturing method |
| CN102743287A (en) * | 2011-04-20 | 2012-10-24 | 江苏博生医用新材料股份有限公司 | New type coated drug bottle plug and manufacturing method thereof |
| CN116479392A (en) * | 2023-03-24 | 2023-07-25 | 江苏博生医用新材料股份有限公司 | Medicinal rubber stopper coating film device |
-
2006
- 2006-09-30 CN CN 200610152292 patent/CN1958837A/en active Pending
Cited By (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN101427979B (en) * | 2007-11-09 | 2012-02-01 | 山东省药用玻璃股份有限公司 | Method for preparing semi-coating medical rubber plug |
| CN102743291A (en) * | 2011-04-20 | 2012-10-24 | 江苏博生医用新材料股份有限公司 | Silicone-free high elasticity coated drug bottle plug and manufacturing method |
| CN102743287A (en) * | 2011-04-20 | 2012-10-24 | 江苏博生医用新材料股份有限公司 | New type coated drug bottle plug and manufacturing method thereof |
| CN102743291B (en) * | 2011-04-20 | 2014-03-12 | 江苏博生医用新材料股份有限公司 | Silicone-free high elasticity coated drug bottle plug and manufacturing method |
| CN102743287B (en) * | 2011-04-20 | 2014-03-12 | 江苏博生医用新材料股份有限公司 | Coated drug bottle plug and manufacturing method thereof |
| CN116479392A (en) * | 2023-03-24 | 2023-07-25 | 江苏博生医用新材料股份有限公司 | Medicinal rubber stopper coating film device |
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