CN102743287A - New type coated drug bottle plug and manufacturing method thereof - Google Patents
New type coated drug bottle plug and manufacturing method thereof Download PDFInfo
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- CN102743287A CN102743287A CN2011100991778A CN201110099177A CN102743287A CN 102743287 A CN102743287 A CN 102743287A CN 2011100991778 A CN2011100991778 A CN 2011100991778A CN 201110099177 A CN201110099177 A CN 201110099177A CN 102743287 A CN102743287 A CN 102743287A
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Abstract
The invention discloses a new type coated drug bottle plug and a manufacturing method thereof, comprising a plug crown and a plug neck, wherein a sealing face between a bottle plug crown part and a plug port as well as a plug neck part are respectively provided with a coating layer. The method for manufacturing the coated drug bottle plug is as follows: 1) with adoption of a routine process, vulcanizing and forming integrated rubber sheets which are connected with plural bottle plugs via film partition sides through a bottle plug mould; 2) covering and sealing the plug crown face part of the single integrated rubber sheet or that of two integrated rubber sheets which are correspondingly clung and fixed with each other as a whole with shielding barriers; 3) coating the integrated rubber sheets which are covered and sealed as a whole; 4) removing the shielding barriers from the plug crown face parts; and 5) annularly punching the integrated rubber sheets which are coated at punching points to obtain a finished product of the new type coated drug bottle plug. Compared with the existing bottle plug, the drug bottle plug produced by the invention is of better drug compatibility.
Description
Technical field
The present invention relates to a kind of medicine bottle stopper of pharmaceutical field of packaging material, be local plated film apothecary jar
Plug, particularly a kind of novel plated film medicine bottle stopper and manufacturing approach thereof.
Background technology
As everyone knows, medicinal bottle stopper is direct and the contacted elastomer packaging material of medicine, has an effect between meeting and the medicine, causes stability of drug poor.The consistency problem of bottle stopper and medicine has a strong impact on the quality of medicine, brings drug safety hidden danger to the patient.In order to solve the consistency problem of bottle stopper and medicine, the technology that adopts at present comprises: the first coats poly tetrafluoroethylene at the plug neck portion that bottle stopper and medicine directly contact; It two is to be to adopt evaporating deposition technique at the whole surface plating of bottle stopper one deck Parylene material to bottle stopper.Rete through coating forms deadening to plug, prevents that precipitate possible in the plug from impacting medicine.Method one needs to adopt the two-step method moulding process, the first step, and the neck of leaving the boundary is produced in elder generation's sulfuration, is die-cut into single bottle stopper plug neck, in second step, the plug neck is put into mould carry out being connected of post-cure molding formation and plug hat.There is following shortcoming in this technology: 1) need carry out secondary forming process, and complex process, production efficiency is low; Because of the ductility the subject of knowledge and the object of knowledge limit of its poly tetrafluoroethylene, the probability of rupture of membranes is very big, influences dependability, has hidden danger of quality again; 2) only be applicable to the bottle stopper that planform is fairly simple, high for the complicated shape manufacturing cost, the finished product rate is extremely low; 3) because protective film is only local at the plug neck; Medicine still can be penetrated into the plug hat and bottleneck sealing surface of no overlay film; For the very strong infusion preparation of sodium bicarbonate class extractibility, be enough to cause the defective of medicine with a spot of contact of plug, there is hidden danger in the safety of medicine reliability.Though the reasonable consistency problem that solves medicine of second method; Avoid the use of silicone oil; But still have following shortcoming: coatings coats bottle stopper fully, and strain is less when causing bottle stopper to use, and forms with the bottleneck seal junction at the plug hat easily and reveals; Cause the poor sealing performance of bottle stopper to medicine, security reliability is affected.
Summary of the invention
The objective of the invention is to overcome the deficiency in the existing medicine bottle stopper manufacturing process technology, provide " a kind of
Novel plated film medicine bottle stopper and manufacturing approach thereof ".This bottle stopper reasonable in design, its manufacturing approach has the worker
Skill simple and stable, energy-saving and cost-reducing, environmental pollution is little, production cost is low advantage are a kind of can effectively enhancing productivity and the novel plated film medicine bottle stopper manufacturing approach of finished product rate.The medicine bottle stopper of producing compare with existing bottle stopper have better drug compatibility can, be a kind of good seal performance, guarantee the novel plated film medicine bottle stopper of the stability of drug products of packing and security reliability.
To achieve these goals, the present invention realizes through following technical scheme: a kind of novel plated film medicine bottle stopper includes plug hat, plug neck; Said plug neck has two kinds of versions, and its a kind of outer wall is the face of cylinder, and sidepiece has one with upper shed; Inwall is a cylinder, and the another kind of outer wall of said plug neck is the face of cylinder, and spigot surface is arranged at the bottom; Inwall is the taper cylinder, labels centre of surface at said plug and is provided with acupuncture ring, between acupuncture ring circumferential edges and plug hat circumferential edges, is provided with antiseized convexity.
Be provided with coatings at bottle stopper bizet and bottleneck sealing surface and plug cervical region position.
Its used material of said coatings is the Parylene material, and its coatings thickness is 0.05-20 μ m.
Its used material of said bottle stopper is a kind of in natural rubber, polyisoprene rubber, butyl rubber, halogenated butyl rubber and the TPO.
The manufacturing approach of described a kind of novel plated film medicine bottle stopper, concrete steps are following:
1) adopts common process, connect the integrated film of a plurality of bottle stoppers through bottle stopper mould sulfidization molding by minute film limit;
2) the plug crown with above-mentioned integrated film partly adopts shielding deadening thing to carry out full wafer covering sealing;
3) the above-mentioned integrated film that has covered sealing is carried out the full wafer plated film;
4) remove plug crown partly shielding effect and deaden thing;
5) it is die-cut the integrated film behind plated film to be made annular at die-cut some place, obtains novel plated film medicine bottle stopper finished product.
The opposing party's manufacturing approach of described a kind of novel plated film medicine bottle stopper, concrete steps are following:
1) adopts common process, connect the integrated film of a plurality of bottle stoppers through bottle stopper mould sulfidization molding by minute film limit;
2) earlier with the plug crown part of two integrated films in opposite directions correspondence be adjacent to fixingly, adopt shielding to deaden peripheral position that thing will above-mentioned corresponding proximate integrated film in opposite directions then and position to cover and seal;
3) the above-mentioned integrated film that has covered sealing is carried out the full wafer plated film;
4) remove plug crown partly shielding effect and deaden thing;
5) it is die-cut the integrated film behind plated film to be made annular at die-cut some place, obtains novel plated film medicine bottle stopper finished product.
It is plastic adhesive tape that described shielding deadens thing.
The die-cut employing die cutting die of said annular is directly die-cut.
The medicine bottle stopper that adopts manufacturing approach of the present invention to produce is compared with existing bottle stopper, has following advantage:
1. this bottle stopper reasonable in design, its manufacturing approach have the technology simple and stable, energy-saving and cost-reducing, environmental pollution is little, production cost is low, effectively improve the advantage of finished product rate.The medicine bottle stopper of producing compare with existing bottle stopper have better drug compatibility can, be a kind of good seal performance, guarantee the novel plated film medicine bottle stopper of the stability of drug products of packing and security reliability.
2. adopting shielding to deaden thing partly carries out full wafer with the plug crown of integrated film (monolithic or biplate) and covers after the sealing coating process again; Only at glue stopper neck and the local plated film of sealing surface; Promptly improved the compatibility of bottle stopper, solved better again that full coated plug strain is little, the shortcoming of poor sealing performance medicine.
3. deaden plug crown plated film one-shot forming technique again because of product adopts shielding earlier, its production efficiency can be enhanced about more than once, and qualified products reaches 99%, and is energy-saving and cost-reducing, obviously reduces production costs.
Description of drawings
Fig. 1 (a) is the medicine bottle stopper sectional structure sketch map that the present invention has first kind of plug neck structure
Fig. 1 (b) is the medicine bottle stopper sectional structure sketch map that the present invention has another kind of plug neck structure
Fig. 2 is the not sectional structure sketch map of the integrated film of plated film bottle stopper of the present invention.
Fig. 3 is that the embodiment of the invention 1 adopts shielding to deaden thing carries out monolithic covering sealing to the plug crown integrated film sectional structure sketch map.
Fig. 4 is that the embodiment of the invention 2 adopts shielding deadening thing that two corresponding in opposite directions peripheral positions that coincide proximate integrated film are positioned the sectional structure sketch map that covers sealing.
Fig. 5 is the present invention's sectional structure sketch map of the integrated film of plated film bottle stopper.
Fig. 6 is that sealing property of the present invention detects tables of data 1.
Fig. 7 is that chemical property of the present invention detects tables of data 2
Among the figure: 1, plug hat, 2, the plug neck, 3, the face of cylinder, 4, opening, 5, cylinder, 6, spigot surface, 7, the taper cylinder, 8, acupuncture ring, 9, antiseized convexity, 10, coatings, 11, divide the mould limit, 12, die-cut point, 13, shielding deadens thing.
The specific embodiment
Through non-limiting example, further set forth the present invention below, understand the present invention.
Embodiment 1
The present invention such as Fig. 1, Fig. 2, Fig. 3, shown in Figure 5, this novel plated film medicine bottle stopper include plug hat, plug neck, and said plug neck has two kinds of versions; Its a kind of outer wall is the face of cylinder, and sidepiece has one with upper shed, and inwall is a cylinder; The another kind of outer wall of said plug neck is the face of cylinder, and spigot surface is arranged at the bottom, and inwall is the taper cylinder; Label centre of surface at said plug and be provided with acupuncture ring, between acupuncture ring circumferential edges and plug hat circumferential edges, be provided with antiseized convexity.Be provided with coatings at bottle stopper bizet and bottleneck sealing surface and plug cervical region position.
Its used material of said coatings is a Parylene, and its coatings thickness is 2.5 μ m.
Its used material of said bottle stopper is a halogenated butyl rubber.
Described manufacturing approach, concrete steps are following:
1) adopts common process, connect the integrated film of a plurality of bottle stoppers through bottle stopper mould sulfidization molding by minute film limit;
2) partly adopt shielding to deaden thing above-mentioned plug crown and carry out full wafer covering sealing through integrated film;
3) the above-mentioned integrated film that has covered sealing is carried out the full wafer plated film;
4) remove plug crown partly shielding effect and deaden thing;
5) it is die-cut the integrated film behind plated film to be made annular at die-cut some place, obtains novel plated film medicine bottle stopper finished product.The die-cut employing die cutting die of annular is directly die-cut.
Remove coating process, all the other adopt common process and common apparatus manufacturing.
The present invention such as Fig. 1, Fig. 2, Fig. 4, shown in Figure 5; This novel its structure of plated film medicine bottle stopper and manufacturing approach and embodiment 1 are basic identical; Different is: earlier with the plug crown part of two integrated films corresponding in opposite directions coincide be adjacent to fixing; Adopt plastic adhesive tape that the corresponding in opposite directions peripheral position that coincide proximate integrated film is positioned the covering sealing then, then the integrated film that covers sealing is carried out the full wafer plated film.
The novel plated film medicine bottle stopper that above embodiment designed, makes relevant department has carried out detection, test to its combination property, and examining report is following:
One. sealing property detects
Inspection center of our unit
The sample title: novel plated film medicine bottle stopper (the present invention),
Detect foundation and/judgment basis: ISO 8871-5
Detect data/result.See table 1
Two. chemical property detects
Inspection center of our unit
The sample title: novel plated film medicine bottle stopper (the present invention),
Detect foundation and/judgment basis:
ISO 8871-1
Detect data/result.See table 2
Detect through above embodiment and combination property; Adopt the present invention to design novel its index of plated film medicine bottle stopper of making and obviously be superior to not plated film medicine bottle stopper of routine; The precipitate that is the plated film bottle stopper obviously is less than ordinary bottle plug, thereby can reduce to minimum to the influence of medicine; Bottle stopper and common plug sealing detect and also meet related standard requirements fully.
In sum, the present invention has reasonable in design, its manufacturing approach have the technology simple and stable, energy-saving and cost-reducing, environmental pollution is little, production cost is low, effectively improve the advantage of finished product rate, its production efficiency can be enhanced about more than once.The medicine bottle stopper of producing compare with existing bottle stopper have better drug compatibility can, be a kind of good seal performance, guarantee the novel plated film medicine bottle stopper of the stability of drug products of packing, medicinal effectiveness and security reliability.
Claims (7)
1. a novel plated film medicine bottle stopper includes plug hat (1), plug neck (2), and said plug neck (2) has two kinds of versions; Its a kind of outer wall is the face of cylinder (3), and sidepiece has one with upper shed (4), and inwall is cylinder (5); The another kind of outer wall of said plug neck is the face of cylinder (3), and spigot surface (6) is arranged at the bottom, and inwall is taper cylinder (7); Label centre of surface at said plug and be provided with acupuncture ring (8); Between acupuncture ring (8) circumferential edges and plug hat circumferential edges, be provided with antiseized convexity (9), it is characterized in that, at the bottle stopper bizet with the bottleneck sealing surface and fill in the cervical region position and be provided with coatings (10).
2. a kind of novel plated film medicine bottle stopper according to claim 1 is characterized in that its used material of said coatings (10) is the Parylene material, and its coatings thickness is 0.05-20 μ m.
3. a kind of novel plated film medicine bottle stopper according to claim 1 is characterized in that, its used material of said bottle stopper is a kind of in natural rubber, polyisoprene rubber, butyl rubber, halogenated butyl rubber and the TPO.
4. the manufacturing approach of an a kind of novel plated film medicine bottle stopper as claimed in claim 1 is characterized in that, said manufacturing approach, and concrete steps are following:
1) adopts common process, connect the integrated film of a plurality of bottle stoppers through bottle stopper mould sulfidization molding by minute film limit (11);
2) the plug crown with above-mentioned integrated film partly adopts shielding deadening thing (13) to carry out full wafer covering sealing;
3) the above-mentioned integrated film that has covered sealing is carried out the full wafer plated film;
4) remove plug crown partly shielding effect and deaden thing (13);
5) it is die-cut the integrated film behind plated film to be located to make annular at die-cut point (12), obtains novel plated film medicine bottle stopper finished product.
5. the manufacturing approach of a kind of novel plated film medicine bottle stopper as claimed in claim 1 is characterized in that, said manufacturing approach, and concrete steps are following:
1) adopts common process, connect the integrated film of a plurality of bottle stoppers through bottle stopper mould sulfidization molding by minute film limit (11);
2) earlier with the plug crown part of two integrated films in opposite directions correspondence be adjacent to fixingly, adopt shielding to deaden peripheral position that thing (13) will above-mentioned corresponding proximate integrated film in opposite directions then and position to cover and seal;
3) the above-mentioned integrated film that has covered sealing is carried out the full wafer plated film;
4) remove plug crown partly shielding effect and deaden thing (13);
5) it is die-cut the integrated film behind plated film to be located to make annular at die-cut point (12), obtains novel plated film medicine bottle stopper finished product.
6. according to the manufacturing approach of claim 4 or 5 described a kind of novel plated film medicine bottle stoppers, it is characterized in that step 2) described in shielding to deaden thing (13) be plastic adhesive tape.
7. according to the manufacturing approach of claim 4 or 5 described a kind of novel plated film medicine bottle stoppers, it is characterized in that it is die-cut to locate to make annular at die-cut point (12), the die-cut employing die cutting die of said annular is directly die-cut.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201110099177.8A CN102743287B (en) | 2011-04-20 | 2011-04-20 | Coated drug bottle plug and manufacturing method thereof |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201110099177.8A CN102743287B (en) | 2011-04-20 | 2011-04-20 | Coated drug bottle plug and manufacturing method thereof |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| CN102743287A true CN102743287A (en) | 2012-10-24 |
| CN102743287B CN102743287B (en) | 2014-03-12 |
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| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN201110099177.8A Active CN102743287B (en) | 2011-04-20 | 2011-04-20 | Coated drug bottle plug and manufacturing method thereof |
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Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN104908187A (en) * | 2015-06-30 | 2015-09-16 | 江苏博生医用新材料股份有限公司 | Novel pharmaceutical bottle stopper of composite structure and production method of novel pharmaceutical bottle stopper |
Citations (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN2441750Y (en) * | 2000-06-23 | 2001-08-08 | 程继勇 | Rubber bottle stopper with film coated on surface for medicine |
| CN1958837A (en) * | 2006-09-30 | 2007-05-09 | 徐志淮 | Technique for vacuum coating bottle closure of rubber |
| CN101147719A (en) * | 2007-09-19 | 2008-03-26 | 湖北华强科技有限责任公司 | Medical local film capsule and producing method thereof |
| CN101287553A (en) * | 2005-09-20 | 2008-10-15 | 拜奥梅留克斯公司 | Specimen enclosure apparatus and containers and closure devices for the same |
| CN101411673A (en) * | 2007-10-21 | 2009-04-22 | 张吕义 | Medicinal film coating plug |
-
2011
- 2011-04-20 CN CN201110099177.8A patent/CN102743287B/en active Active
Patent Citations (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN2441750Y (en) * | 2000-06-23 | 2001-08-08 | 程继勇 | Rubber bottle stopper with film coated on surface for medicine |
| CN101287553A (en) * | 2005-09-20 | 2008-10-15 | 拜奥梅留克斯公司 | Specimen enclosure apparatus and containers and closure devices for the same |
| CN1958837A (en) * | 2006-09-30 | 2007-05-09 | 徐志淮 | Technique for vacuum coating bottle closure of rubber |
| CN101147719A (en) * | 2007-09-19 | 2008-03-26 | 湖北华强科技有限责任公司 | Medical local film capsule and producing method thereof |
| CN101411673A (en) * | 2007-10-21 | 2009-04-22 | 张吕义 | Medicinal film coating plug |
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN104908187A (en) * | 2015-06-30 | 2015-09-16 | 江苏博生医用新材料股份有限公司 | Novel pharmaceutical bottle stopper of composite structure and production method of novel pharmaceutical bottle stopper |
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| Publication number | Publication date |
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| CN102743287B (en) | 2014-03-12 |
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