CN102743287B - Coated drug bottle plug and manufacturing method thereof - Google Patents
Coated drug bottle plug and manufacturing method thereof Download PDFInfo
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- CN102743287B CN102743287B CN201110099177.8A CN201110099177A CN102743287B CN 102743287 B CN102743287 B CN 102743287B CN 201110099177 A CN201110099177 A CN 201110099177A CN 102743287 B CN102743287 B CN 102743287B
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Abstract
The invention discloses a new type coated drug bottle plug and a manufacturing method thereof, comprising a plug crown and a plug neck, wherein a sealing face between a bottle plug crown part and a plug port as well as a plug neck part are respectively provided with a coating layer. The method for manufacturing the coated drug bottle plug is as follows: 1) with adoption of a routine process, vulcanizing and forming integrated rubber sheets which are connected with plural bottle plugs via film partition sides through a bottle plug mould; 2) covering and sealing the plug crown face part of the single integrated rubber sheet or that of two integrated rubber sheets which are correspondingly clung and fixed with each other as a whole with shielding barriers; 3) coating the integrated rubber sheets which are covered and sealed as a whole; 4) removing the shielding barriers from the plug crown face parts; and 5) annularly punching the integrated rubber sheets which are coated at punching points to obtain a finished product of the new type coated drug bottle plug. Compared with the existing bottle plug, the drug bottle plug produced by the invention is of better drug compatibility.
Description
Technical field
The present invention relates to a kind of medicine bottle stopper of pharmaceutical field of packaging material, is local plated film apothecary jar
Plug, particularly a kind of Novel film-coated medicine bottle stopper and manufacture method thereof.
Background technology
As everyone knows, medicinal bottle stopper is the elastomer packaging material that directly contact with medicine, between meeting and medicine, has an effect, and causes the poor stability of medicine.The consistency problem of bottle stopper and medicine has a strong impact on the quality of medicine, to patient, brings drug safety hidden danger.In order to solve the consistency problem of bottle stopper and medicine, the technology adopting at present comprises: the coated poly tetrafluoroethylene of plug neck portion that the first directly contacts with medicine at bottle stopper; It two is to be to adopt evaporating deposition technique at the whole plated surface one deck of bottle stopper Parylene material to bottle stopper.By coated rete, plug is formed and deadened, prevent that precipitate possible in plug from impacting medicine.Method one need to adopt two-step method moulding process, the first step, and the neck of leaving the boundary is produced in first sulfuration, is die-cut into single bottle stopper plug neck, and second step is put into mould by plug neck and is carried out being connected of post-cure molding formation and plug hat.There is following shortcoming in this technique: 1) need to carry out secondary forming process, and complex process, production efficiency is low; Because of the ductility the subject of knowledge and the object of knowledge limit of its poly tetrafluoroethylene, the probability of rupture of membranes is very big, affects dependability, has hidden danger of quality again; 2) be only applicable to the fairly simple bottle stopper of planform, high for complicated shape manufacturing cost, finished product rate is extremely low; 3) because protective film is only local at plug neck; medicine still can be penetrated into the plug hat and bottle sealing face without overlay film; for the very strong infusion preparation of sodium bicarbonate class extractibility, contact a small amount of with plug is enough to cause the defective of medicine, and safety of medicine reliability exists hidden danger.Although the reasonable consistency problem that solves medicine of second method, avoid using silicone oil, but still there is following shortcoming: film plating layer is coated bottle stopper completely, while causing bottle stopper to use, strain is less, easily at plug hat, form and reveal with bottle sealing joint portion, cause the poor sealing performance of bottle stopper to medicine, security reliability is affected.
Summary of the invention
The object of the invention is to overcome the deficiency in existing medicine bottle stopper manufacturing process technology, provide " a kind of
Novel film-coated medicine bottle stopper and manufacture method thereof ".This bottle plug structure is reasonable in design, and its manufacture method has work
Skill simple and stable, the advantage that energy-saving and cost-reducing, environmental pollution is little, production cost is low are a kind of can effectively enhancing productivity and the Novel film-coated medicine bottle stopper manufacture method of finished product rate.The medicine bottle stopper of producing compare with existing bottle stopper and there is better drug compatibility energy, be a kind of good seal performance, guarantee the Novel film-coated medicine bottle stopper of packaging stability of drug products and security reliability.
To achieve these goals, the present invention is achieved through the following technical solutions: a kind of Novel film-coated medicine bottle stopper, include plug hat, plug neck, and described plug neck has two kinds of versions, its a kind of outer wall is the face of cylinder, sidepiece has one with upper shed, and inwall is cylinder, and the another kind of outer wall of described plug neck is the face of cylinder, spigot surface is arranged at bottom, inwall is taper cylinder, labels centre of surface be provided with acupuncture ring at described plug, between acupuncture ring circumferential edges and plug hat circumferential edges, is provided with antiseized projection.
At bottle stopper bizet and bottle sealing face and plug cervical region position, be provided with film plating layer.
Its material used of described film plating layer is Parylene material, and its film plating layer thickness is 0.05-20 μ m.
Its material used of described bottle stopper is a kind of in natural rubber, polyisoprene rubber, butyl rubber, halogenated butyl rubber and TPO.
The manufacture method of described a kind of Novel film-coated medicine bottle stopper, concrete steps are as follows:
1) adopt common process, by bottle stopper mould sulfidization molding, by minute film limit, connected the integrated film of a plurality of bottle stoppers;
2) the plug crown of above-mentioned integrated film is partly adopted shielding deaden thing and carry out full wafer covering sealing;
3) the above-mentioned integrated film that has covered sealing is carried out to full wafer plated film;
4) remove plug crown partly shielding effect and deaden thing;
5) die-cut in die-cut some place work annular to the integrated film after plated film, obtain Novel film-coated medicine bottle stopper finished product.
The opposing party's manufacture method of described a kind of Novel film-coated medicine bottle stopper, concrete steps are as follows:
1) adopt common process, by bottle stopper mould sulfidization molding, by minute film limit, connected the integrated film of a plurality of bottle stoppers;
2) first by the plug crown part of two integrated films in opposite directions correspondence be adjacent to fixingly, then adopt shielding to deaden thing the above-mentioned periphery position of the corresponding integrated film being adjacent to in opposite directions positioned and covers sealing;
3) the above-mentioned integrated film that has covered sealing is carried out to full wafer plated film;
4) remove plug crown partly shielding effect and deaden thing;
5) die-cut in die-cut some place work annular to the integrated film after plated film, obtain Novel film-coated medicine bottle stopper finished product.
It is plastic adhesive tape that described shielding deadens thing.
The die-cut employing die cutting die of described annular is directly die-cut.
The medicine bottle stopper that adopts manufacture method of the present invention to produce is compared with existing bottle stopper, and tool has the following advantages:
1. this bottle plug structure is reasonable in design, and its manufacture method has advantages of technique simple and stable, energy-saving and cost-reducing, environmental pollution is little, production cost is low, effectively improve finished product rate.The medicine bottle stopper of producing compare with existing bottle stopper and there is better drug compatibility energy, be a kind of good seal performance, guarantee the Novel film-coated medicine bottle stopper of packaging stability of drug products and security reliability.
2. adopting shielding to deaden thing partly carries out full wafer by the plug crown of integrated film (monolithic or biplate) and covers after sealing coating process again, only at glue stopper neck and the local plated film of sealing surface, improved the compatibility of bottle stopper to medicine, better solved again that full coated plug strain is little, the shortcoming of poor sealing performance.
3. because product adopts first shielding, deaden plug crown plated film one-shot forming technique again, its production efficiency can be enhanced about more than once, and product is qualified reaches 99%, energy-saving and cost-reducing, obviously reduces production costs.
Accompanying drawing explanation
Fig. 1 (a) is the medicine bottle stopper sectional structure schematic diagram that the present invention has the first plug neck structure
Fig. 1 (b) is the medicine bottle stopper sectional structure schematic diagram that the present invention has another kind of plug neck structure
Fig. 2 is the not sectional structure schematic diagram of the integrated film of bottle stopper coated with film of the present invention.
Fig. 3 is that the embodiment of the present invention 1 adopts shielding deadening thing to carry out to plug crown the integrated film sectional structure schematic diagram that monolithic covers sealing.
Fig. 4 is that the embodiment of the present invention 2 adopts shielding to deaden things the periphery position of two corresponding in opposite directions integrated films of being adjacent to of coincideing is positioned to the sectional structure schematic diagram that covers sealing.
Fig. 5 is the present invention's sectional structure schematic diagram of the integrated film of bottle stopper coated with film.
Fig. 6 is that sealing property of the present invention detects tables of data 1.
Fig. 7 is that chemical property of the present invention detects tables of data 2
In figure: 1, plug hat, 2, plug neck, 3, the face of cylinder, 4, opening, 5, cylinder, 6, spigot surface, 7, taper cylinder, 8, acupuncture ring, 9, antiseized projection, 10, film plating layer, 11, parting limit, 12, die-cut point, 13, shielding deadens thing.
The specific embodiment
Below by non-limiting example, further set forth the present invention, understand the present invention.
Embodiment 1
The present invention as shown in Figure 1, Figure 2, shown in Fig. 3, Fig. 5, this Novel film-coated medicine bottle stopper includes plug hat, plug neck, described plug neck has two kinds of versions, and its a kind of outer wall is the face of cylinder, and sidepiece has one with upper shed, inwall is cylinder, the another kind of outer wall of described plug neck is the face of cylinder, and spigot surface is arranged at bottom, and inwall is taper cylinder, at described plug, label centre of surface and be provided with acupuncture ring, between acupuncture ring circumferential edges and plug hat circumferential edges, be provided with antiseized projection.At bottle stopper bizet and bottle sealing face and plug cervical region position, be provided with film plating layer.
Its material used of described film plating layer is Parylene, and its film plating layer thickness is 2.5 μ m.
Its material used of described bottle stopper is halogenated butyl rubber.
Described manufacture method, concrete steps are as follows:
1) adopt common process, by bottle stopper mould sulfidization molding, by minute film limit, connected the integrated film of a plurality of bottle stoppers;
2) the above-mentioned plug crown through integrated film is partly adopted shielding deaden thing and carry out full wafer covering sealing;
3) the above-mentioned integrated film that has covered sealing is carried out to full wafer plated film;
4) remove plug crown partly shielding effect and deaden thing;
5) die-cut in die-cut some place work annular to the integrated film after plated film, obtain Novel film-coated medicine bottle stopper finished product.The die-cut employing die cutting die of annular is directly die-cut.
Except coating process, all the other adopt common process and common apparatus manufacture.
Embodiment 2
The present invention as shown in Figure 1, Figure 2, shown in Fig. 4, Fig. 5, this its structure of Novel film-coated medicine bottle stopper and manufacture method are substantially the same manner as Example 1, difference is: first by the plug crown part of two integrated films corresponding in opposite directions coincide be adjacent to fixing, then adopt plastic adhesive tape that the periphery position of the corresponding in opposite directions integrated film that is adjacent to of coincideing is positioned and covers sealing, then to covering the integrated film of sealing, carry out full wafer plated film.
The Novel film-coated medicine bottle stopper that above embodiment is designed, manufacture relevant department has carried out detection, test to its combination property, and examining report is as follows:
One. sealing property detects
Inspection center of our unit
Sample title: Novel film-coated medicine bottle stopper (the present invention),
Detect foundation and/judgment basis: ISO 8871-5
Detect data/result.In Table 1
Two. chemical property detects
Inspection center of our unit
Sample title: Novel film-coated medicine bottle stopper (the present invention),
Detect foundation and/judgment basis:
iSO 8871-1
Detect data/result.In Table 2
By above embodiment and combination property, detect, adopt its index of Novel film-coated medicine bottle stopper of the designed manufacture of the present invention to be obviously better than not plated film medicine bottle stopper of routine, the precipitate that is bottle stopper coated with film is obviously less than ordinary bottle plug, thereby can reduce to minimum to the impact of medicine; Bottle stopper and common plug sealing propertytest also meet related standard requirements completely.
In sum, the present invention has reasonable in design, and its manufacture method has advantages of technique simple and stable, energy-saving and cost-reducing, environmental pollution is little, production cost is low, effectively improve finished product rate, and its production efficiency can be enhanced about more than once.The medicine bottle stopper of producing compare with existing bottle stopper and there is better drug compatibility energy, be a kind of good seal performance, guarantee the Novel film-coated medicine bottle stopper of packaging stability of drug products, medicinal effect and security reliability.
Claims (5)
1. the manufacture method of a Novel film-coated medicine bottle stopper, it is characterized in that described bottle stopper includes plug hat (1), plug neck (2), described plug neck (2) has two kinds of versions, its a kind of outer wall is the face of cylinder (3), sidepiece has one with upper shed (4), inwall is cylinder (5), the another kind of outer wall of described plug neck is the face of cylinder (3), spigot surface (6) is arranged at bottom, inwall is taper cylinder (7), at described plug, label centre of surface and be provided with acupuncture ring (8), between acupuncture ring (8) circumferential edges and plug hat circumferential edges, be provided with antiseized projection (9), it is characterized in that, at bottle stopper bizet and bottle sealing face and plug cervical region position, be provided with film plating layer (10),
Wherein, described manufacture method concrete steps are as follows:
1) adopt common process, by bottle stopper mould sulfidization molding, by minute film limit (11), connected the integrated film of a plurality of bottle stoppers;
2) first by the plug crown part of two integrated films in opposite directions correspondence be adjacent to fixingly, then adopt shielding to deaden thing (13) the above-mentioned periphery position of the corresponding integrated film being adjacent to in opposite directions positioned and covers sealing;
3) the above-mentioned integrated film that has covered sealing is carried out to full wafer plated film;
4) remove plug crown partly shielding effect and deaden thing (13);
5) the integrated film after plated film is located to make annular at die-cut point (12) die-cut, obtain Novel film-coated medicine bottle stopper finished product.
2. method according to claim 1, is characterized in that, its material used of described film plating layer (10) is Parylene material, and its film plating layer thickness is 0.05-20 μ m.
3. method according to claim 1, is characterized in that, its material used of described bottle stopper is a kind of in natural rubber, polyisoprene rubber, butyl rubber, halogenated butyl rubber and TPO.
4. method according to claim 1, is characterized in that step 2) described in shielding to deaden thing (13) be plastic adhesive tape.
5. method according to claim 1, is characterized in that, die-cut being specially of the annular described in step 5) adopts die cutting die directly die-cut.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201110099177.8A CN102743287B (en) | 2011-04-20 | 2011-04-20 | Coated drug bottle plug and manufacturing method thereof |
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| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201110099177.8A CN102743287B (en) | 2011-04-20 | 2011-04-20 | Coated drug bottle plug and manufacturing method thereof |
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| CN102743287A CN102743287A (en) | 2012-10-24 |
| CN102743287B true CN102743287B (en) | 2014-03-12 |
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Families Citing this family (1)
| Publication number | Priority date | Publication date | Assignee | Title |
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| CN104908187A (en) * | 2015-06-30 | 2015-09-16 | 江苏博生医用新材料股份有限公司 | Novel pharmaceutical bottle stopper of composite structure and production method of novel pharmaceutical bottle stopper |
Citations (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN2441750Y (en) * | 2000-06-23 | 2001-08-08 | 程继勇 | Rubber bottle cap for surface film coated medicine |
| CN1958837A (en) * | 2006-09-30 | 2007-05-09 | 徐志淮 | Technique for vacuum coating bottle closure of rubber |
| CN101147719A (en) * | 2007-09-19 | 2008-03-26 | 湖北华强科技有限责任公司 | Medical local film capsule and producing method thereof |
| CN101287553A (en) * | 2005-09-20 | 2008-10-15 | 拜奥梅留克斯公司 | Specimen enclosure apparatus and containers and closure devices for the same |
| CN101411673A (en) * | 2007-10-21 | 2009-04-22 | 张吕义 | Medicinal film coating plug |
-
2011
- 2011-04-20 CN CN201110099177.8A patent/CN102743287B/en active Active
Patent Citations (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN2441750Y (en) * | 2000-06-23 | 2001-08-08 | 程继勇 | Rubber bottle cap for surface film coated medicine |
| CN101287553A (en) * | 2005-09-20 | 2008-10-15 | 拜奥梅留克斯公司 | Specimen enclosure apparatus and containers and closure devices for the same |
| CN1958837A (en) * | 2006-09-30 | 2007-05-09 | 徐志淮 | Technique for vacuum coating bottle closure of rubber |
| CN101147719A (en) * | 2007-09-19 | 2008-03-26 | 湖北华强科技有限责任公司 | Medical local film capsule and producing method thereof |
| CN101411673A (en) * | 2007-10-21 | 2009-04-22 | 张吕义 | Medicinal film coating plug |
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