CN1954873B - Traditional Chinese medicine composition and its preparation method - Google Patents
Traditional Chinese medicine composition and its preparation method Download PDFInfo
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- CN1954873B CN1954873B CN2006101597975A CN200610159797A CN1954873B CN 1954873 B CN1954873 B CN 1954873B CN 2006101597975 A CN2006101597975 A CN 2006101597975A CN 200610159797 A CN200610159797 A CN 200610159797A CN 1954873 B CN1954873 B CN 1954873B
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Abstract
A Chinese medicine for treating the itch of skin and pudendum is prepared from 16 Chinese-medicinal materials including effervescent sophora root, cnidium fruit, peach twig, Chuan-xiong rhizome, etc. Its preparing process is also disclosed.
Description
Technical field
The present invention relates to a kind of Chinese medicine composition and preparation method thereof, belong to the field of Chinese medicines.
Background technology
Vaginitis is the inflammation of connective tissue under vaginal mucosa and the mucosa, is the common disease of gynecological's outpatient service.Vaginitis changes with the character of leucorrhea clinically and the pudendum infections is itched, and causalgia is main clinical characters, vagina has the nature defense function to the intrusion of pathogen, when the natural defense function of vagina is destroyed, then pathogen is easy to invade, cause colpitis, common vaginitis has bacterial vaginitis, trichomonal vaginitis, colpitis mycotica, senile vaginitis etc., and sickness rate such as trichomonal vaginitis, colpitis mycotica is on the rise in recent years.Therefore, it is very necessary to explore a kind of medicine for the treatment of such disease.
Summary of the invention
It is external to the purpose of this invention is to provide a kind of preparation treatment ailment said due to cold or exposure, accumulates Chinese medicine composition of using in the disease medicines such as skin due to space between skin and muscles is become estranged and pudendal pruritus and preparation method thereof in the noxious dampness.
The present invention seeks to be achieved through the following technical solutions:
The composition of crude drug comprises the flavour of a drug of following weight portion:
Radix Sophorae Flavescentis 15-60 weight portion Cacumen Tamaricis 15-60 weight portion Fructus Cnidii 15-60 weight portion
Herba Portulacae 15-60 weight portion Herba Schizonepetae 15-60 weight portion Cortex Dictamni 15-60 weight portion
Radix Stemonae 15-60 weight portion Nidus Vespae 10-30 weight portion Ramulus Persicae 15-60 weight portion
Ramulus Salicis Babylonicae 15-60 weight portion Rumalus sophorae 1560 weight portion Rhizoma Chuanxiong 10-30 weight portions
Fructus Tribuli 15-60 weight portion Fructus Kochiae 15-60 weight portion Radix Angelicae Dahuricae 10-30 weight portion
Folium Artemisiae Argyi 15-60 weight portion
More properly be following bulk drugs:
Radix Sophorae Flavescentis 30 weight portion Cacumen Tamariciss 30 weight portion Fructus Cnidiis 30 weight portions
Herba Portulacae 30 weight portion Herba Schizonepetae 30 weight portion Cortex Dictamni 30 weight portions
The Radix Stemonae 30 weight portion Nidus Vespae 15 weight portion Ramulus Persicae 30 weight portions
Ramulus Salicis Babylonicae 30 weight portion Rumalus sophorae 30 weight portion Rhizoma Chuanxiongs 15 weight portions
The Fructus Tribuli 30 weight portion Fructus Kochiae 30 weight portion Radixs Angelicae Dahuricae 15 weight portions
Folium Artemisiae Argyi 30 weight portions
Use for convenience, also need above crude drug is made modern preparation, the inventor is preferred lotion, suppository, effervescent tablet, soft capsule.At prescription, the inventor has studied preparation technology, comprises extracting refining and preparations shaping two parts, is narrated respectively below.
The washing liquid preparation method:
More than ten Six-elements, decoct with water secondary, add for the first time 5 times of water gagings and decocted 1.5 hours, add 2 times of water gagings for the second time and decocted 1 hour, collecting decoction filters, filtrate is concentrated into the clear paste that relative density is 1.28 ~ 1.32 (50 ℃).The gained clear paste adds corresponding conventional adjuvant, makes washing liquid.
The suppository preparation method:
More than ten Six-elements, decoct with water secondary, add for the first time 5 times of water gagings and decocted 1.5 hours, add 2 times of water gagings for the second time and decocted 1 hour, collecting decoction filters, filtrate is concentrated into the clear paste that relative density is 1.28 ~ 1.32 (50 ℃), spray drying.In the fine drug powder, add corresponding conventional adjuvant, make suppository.
The effervescent tablet preparation method:
More than ten Six-elements, decoct with water secondary, add for the first time 5 times of water gagings and decocted 1.5 hours, add 2 times of water gagings for the second time and decocted 1 hour, collecting decoction filters, filtrate is concentrated into the clear paste that relative density is 1.28 ~ 1.32 (50 ℃), spray drying.In the fine drug powder, add corresponding conventional adjuvant, make the vagina effervescence agent.
The soft capsule preparation method:
More than ten Six-elements, decoct with water secondary, add for the first time 5 times of water gagings and decocted 1.5 hours, add 2 times of water gagings for the second time and decocted collecting decoction 1 hour, filter, filtrate is concentrated into the clear paste that relative density is 1.28 ~ 1.32 (50 ℃), spray drying, and spray powder is by behind 120 mesh sieves, add corresponding conventional adjuvant, make the vagina soft capsule agent.
The specific embodiment:
Pharmaceutical preparation of the present invention can press down pathogenic microorganism such as killing staphylococcus aureus, bacillus pyocyaneus, mycete fast.The inventor cures mainly according to its function, from antiinflammatory, anti-vaginitis, aspect such as antibiotic its pharmacodynamics is verified.
Be subjected to the reagent thing: according to this product preparation that preparation method of the present invention makes, No. 1 is suppository, and No. 2 is lotion.
FUYANXIAO PAOTENGPIAN: Guangzhou Zhongyi Medicine Industry Co., Ltd produces, lot number: 20041111.
Instrument: PB303-N electronic balance, Mettler-Toledo Instrument (Shanghai) Co., Ltd..
Animal: Kunming mouse 18～22g, male and female dual-purpose; White rabbit male and female half and half, 2.0～2.3kg provides by Shandong University's Experimental Animal Center.
Test 1: to the influence of mice granuloma induced by implantation of cotton pellets
Get 50 of mices, male and female half and half are divided into five groups at random, and each Mus is used etherization, and the otch of a long 0.5cm is cut in back cropping sterilization, respectively implant the sterilization cotton balls of a 5mg from otch to the oxter, both sides, sew up the incision.From continuous subcutaneous administration 7d on the operation same day, mice is put to death in dislocation in the 8th day, cut skin of back, cotton balls is taken out together with granulation tissue on every side, reject fatty tissue, place 60 ℃ of drying baker oven dry, accurately take by weighing weight and write down the result, cause scorching cotton balls weight and deduct cotton balls weight and ask poor, the results are shown in Table 1.
The influence of table 1 pair mice granuloma induced by implantation of cotton pellets (X ± S)
Annotate: compare * P＜0.05 with matched group, * * P＜0.01
Table 1 is the result show, this product preparation 1-2 number has inhibitory action to the mice granuloma induced by implantation of cotton pellets.
Test 2: anti-rabbit bacterial vaginitis test
Get 32 rabbit, be divided into 4 groups after the modeling at random.7d vagina pathological changes situation after the administration of observed and recorded infection animal, vaginal swab smear staining microscopy is got in the local film making of vagina, and rabbit lives and kills, and gets that vagina tissue is fixed, section, HE dyeing, microscopy and film making.The results are shown in Table 2.
The criterion recovery from illness: the vagina outward appearance does not have hyperemia, redness, no purulent secretion, and the vaginal swab smear for microscopic examination loses infectious bacteria and non-viable non-apoptotic cell, and mucosa is complete in the vagina tissue section, submucous tissue is normal substantially.Take a turn for the better: the vagina outward appearance has mild hyperaemia, redness, a small amount of purulent secretion is arranged, the visible a small amount of infectious bacteria of vaginal swab smear for microscopic examination and a small amount of non-viable non-apoptotic cell, the visible vaginal mucosa of tissue slice microscopy has slight damaged, telangiectasis in the submucous tissue, erythrocytosis have a small amount of neutrophil infiltration in the tissue.Invalid: the hyperemia of vagina outward appearance, redness, a large amount of purulent secretions are arranged, and the vaginal swab smear for microscopic examination is seen a large amount of infectious bacterias and non-viable non-apoptotic cell, and the visible mucosa of vagina tissue section microscopy has damaged, a large amount of telangiectasis, erythrocytosis in the submucous tissue has a large amount of neutrophil infiltration.
The anti-rabbit bacterial vaginitis of table 2 result of the test (X ± S)
The effective percentage of the anti-rabbit bacterial vaginitis of this product preparation is more than 60% as a result, and the rabbit bacterial vaginitis is had good therapeutical effect.
Test 3: external minimal inhibitory concentration (MIC)
With this product preparation be diluted to 2.175,1.0875,0.5438,0.435,0.3625, a series of concentration of 0.3107/ml, above-mentioned concentration added in the Nutrient medium by 1: 10, the autoclave sterilization sterilization.Each experimental bacteria of preserving is inoculated in the Carnis Bovis seu Bubali cream soup body culture medium growing state on the medicine flat board of 37 ℃ of incubator cultivation 24h taking-up observation variable concentrations respectively.The least concentration that antibacterial does not grow is the MIC of medicine to this antibacterial.The result shows the MIC of this product preparation: bacillus pyocyaneus 110mg/ml, staphylococcus aureus 60mg/ml, Bacillus proteus 60mg/ml.
Below by implementing to further specify technical scheme of the present invention:
Embodiment one
[prescription] Radix Sophorae Flavescentis 30g Cacumen Tamaricis 30g Fructus Cnidii 30g
Herba Portulacae 30g Herba Schizonepetae 30g Cortex Dictamni 30g
Radix Stemonae 30g Nidus Vespae 15g Ramulus Persicae 30g
Ramulus Cinnamomi 30g Rumalus sophorae 30g Rhizoma Chuanxiong 15g
Fructus Tribuli 30g Fructus Kochiae 30g Radix Angelicae Dahuricae 15g
Folium Artemisiae Argyi 30g
[method for making] above ten Six-elements decoct with water secondary, add 5 times of water gagings for the first time and decoct 1.5 hours, add 2 times of water gagings for the second time and decoct 1 hour, and collecting decoction filters, and filtrate is concentrated into the clear paste that relative density is 1.28 ~ 1.32 (50 ℃).Get polyoxyethylenated alcohol sodium sulfate 100g, add water 600ml and make dissolving, other gets glycerol 50g, cellulose 17g, stirs evenly, slowly add in the above-mentioned solution, merge with above-mentioned clear paste again, add sodium benzoate 1.8g, essence 2g, mixing, adjust total amount to 1000ml, mixing, embedding, promptly.
Embodiment two
[prescription] Radix Sophorae Flavescentis 15g Cacumen Tamaricis 15g Fructus Cnidii 15g
Herba Portulacae 15g Herba Schizonepetae 15g Cortex Dictamni 15g
Radix Stemonae 15g Nidus Vespae 10g Ramulus Persicae 15g
Ramulus Cinnamomi 15g Rumalus sophorae 15g Rhizoma Chuanxiong 10g
Fructus Tribuli 15g Fructus Kochiae 15g Radix Angelicae Dahuricae 10g
Folium Artemisiae Argyi 15g
[method for making] above ten Six-elements decoct with water secondary, add 5 times of water gagings for the first time and decoct 1.5 hours, add for the second time 2 times of water gagings and decocted 1 hour, collecting decoction filters, filtrate is concentrated into the clear paste that relative density is 1.28 ~ 1.32 (50 ℃), and spray drying gets spray powder, with spray powder and Arlacel-80 10g, join in the fused 36 type mixed aliphatic esters (50 ℃) mixing in the lump, moulding, take out the cooling back, the system bolt, promptly.
Embodiment three
[prescription] Radix Sophorae Flavescentis 40g Cacumen Tamaricis 40g Fructus Cnidii 40g
Herba Portulacae 40g Herba Schizonepetae 40g Cortex Dictamni 40g
Radix Stemonae 40g Nidus Vespae 20g Ramulus Persicae 40g
Ramulus Salicis Babylonicae 40g Rumalus sophorae 40g Rhizoma Chuanxiong 20g
Fructus Tribuli 40g Fructus Kochiae 40g Radix Angelicae Dahuricae 20g
Folium Artemisiae Argyi 40g
[method for making] above ten Six-elements decoct with water secondary, add 5 times of water gagings for the first time and decoct 1.5 hours, add for the second time 2 times of water gagings and decocted 1 hour, collecting decoction filters, filtrate is concentrated into the clear paste that relative density is 1.28 ~ 1.32 (50 ℃), spray drying, spray powder is standby, gets citric acid, 100 ℃ of dryings make air slaking, pulverize, cross 120 mesh sieves, standby; Get 60 ℃ of dryings of sodium bicarbonate, pulverize, cross 120 mesh sieves, standby; Get said medicine and spray dried fine powder and add exsiccant citric acid 150g, sodium bicarbonate 120g, carboxymethylstach sodium 30g, adjust total amount to 500g with lactose, mix homogeneously, dry-pressing is granulated, and is pressed into 1000, packing, promptly.
Embodiment four
[prescription] Radix Sophorae Flavescentis 60g Cacumen Tamaricis 60g Fructus Cnidii 60g
Herba Portulacae 60g Herba Schizonepetae 60g Cortex Dictamni 60g
Radix Stemonae 60g Nidus Vespae 30g Ramulus Persicae 60g
Ramulus Salicis Babylonicae 60g Rumalus sophorae 60g Rhizoma Chuanxiong 30g
Fructus Tribuli 60g Fructus Kochiae 60g Radix Angelicae Dahuricae 30g
Folium Artemisiae Argyi 60g
[method for making] above ten Six-elements decoct with water secondary, add 5 times of water gagings for the first time and decoct 1.5 hours, add for the second time 2 times of water gagings and decocted 1 hour, collecting decoction filters, filtrate is concentrated into the clear paste that relative density is 1.28 ~ 1.32 (50 ℃), spray drying (180 ℃ of air intakes, 90 ℃ of air-out), spray powder add after by 120 mesh sieves propylene glycol 50g, Polyethylene Glycol-400 in right amount to total amount be 550g, mix homogeneously, colloid mill ground 10 minutes, the dress soft capsule, be pressed into 1000, promptly.
Claims (6)
1. Chinese medicine composition is characterized in that this pharmaceutical composition made by following raw material medicaments:
Radix Sophorae Flavescentis 15-60 weight portion Cacumen Tamaricis 15-60 weight portion Fructus Cnidii 15-60 weight portion
Herba Portulacae 15-60 weight portion Herba Schizonepetae 15-60 weight portion Cortex Dictamni 15-60 weight portion
Radix Stemonae 15-60 weight portion Nidus Vespae 10-30 weight portion Ramulus Persicae 15-60 weight portion
Ramulus Salicis Babylonicae 15-60 weight portion Rumalus sophorae 15-60 weight portion Rhizoma Chuanxiong 10-30 weight portion
Fructus Tribuli 15-60 weight portion Fructus Kochiae 15-60 weight portion Radix Angelicae Dahuricae 10-30 weight portion
Folium Artemisiae Argyi 15-60 weight portion.
2. Chinese medicine composition as claimed in claim 1 is characterized in that this Chinese medicine composition made by following bulk drugs:
Radix Sophorae Flavescentis 30 weight portion Cacumen Tamariciss 30 weight portion Fructus Cnidiis 30 weight portions
Herba Portulacae 30 weight portion Herba Schizonepetae 30 weight portion Cortex Dictamni 30 weight portions
The Radix Stemonae 30 weight portion Nidus Vespae 15 weight portion Ramulus Persicae 30 weight portions
Ramulus Salicis Babylonicae 30 weight portion Rumalus sophorae 30 weight portion Rhizoma Chuanxiongs 15 weight portions
The Fructus Tribuli 30 weight portion Fructus Kochiae 30 weight portion Radixs Angelicae Dahuricae 15 weight portions
Folium Artemisiae Argyi 30 weight portions.
3. Chinese medicine composition as claimed in claim 1 or 2 is characterized in that said composition can be made into clinical required various dosage forms, comprises lotion, suppository, effervescent tablet, soft capsule, spray, gel.
4. the preparation method of Chinese medicine composition as claimed in claim 1 or 2 is characterized in that:
More than ten Six-elements, decoct with water 2～3 times, collecting decoction filters, filtrate is condensed into clear paste; The suitable adjuvant of characteristics adding according to dosage form is prepared into various dosage forms again.
5. the preparation method of Chinese medicine composition as claimed in claim 1 or 2 is characterized in that:
More than ten Six-elements, decoct with water secondary, add for the first time 5 times of water gagings and decocted 1.5 hours, add 2 times of water gagings for the second time and decocted 1 hour, collecting decoction filters, it is 1.28～1.32 clear paste that filtrate is concentrated into 50 ℃ of relative densities; The suitable adjuvant of characteristics adding according to dosage form is prepared into various dosage forms again.
6. Chinese medicine composition as claimed in claim 1 or 2 is external in preparation treatment ailment said due to cold or exposure, accumulates the application in the skin due to space between skin and muscles is become estranged, the pudendal pruritus disease drug in the noxious dampness.
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| CN1954873B true CN1954873B (en) | 2011-06-08 |
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Citations (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1415371A (en) * | 2002-10-21 | 2003-05-07 | 李湛明 | Medicament for curing colpitis mycotica and trichomonal vaginitis and its preparation method |
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| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1415371A (en) * | 2002-10-21 | 2003-05-07 | 李湛明 | Medicament for curing colpitis mycotica and trichomonal vaginitis and its preparation method |
Non-Patent Citations (1)
| Title |
|---|
| 滕振侠.中药治疗阴部瘙痒症21例.中国乡村医药.1998,5(7),14-15. * |
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