CN1951480A - Medicament for treating type 2 diabetes - Google Patents

Abstract

The invention relates to a medicinal composition for treating diabetes which comprises dried rehmannia root, corn stigma, seeds of Job's tears, gen-seng, root of red rooted saliva, licorice root, cornus officinalis, epimeddium, Chinese epedra root, kudzu vine root, root of herbaceous peony, fleece-flower root, astragalus root, pig pancreas and Gliclazide. The medicament can be used for activating beta-cells and lowering blood sugar.

Description

The medicine of treatment type 2 diabetes mellitus

Technical field

The present invention relates to a kind of medicine for the treatment of diabetes, be specially a kind of medicine for the treatment of type 2 diabetes mellitus.

Background technology

Diabetes are one group of endocrine metabolism diseases that the cause of disease is very complicated, it is one group of chronic hyperglycemia clinical syndrome, its basic pathology physiology is the hypoinsulinism of absoluteness or relative property, and target cell is to the sensitivity reduction of insulin, thereby cause sugar, protein, the water of fat and secondary, metabolic disturbance of electrolyte, can cause acid base imbalance when serious, its characteristic is: hyperglycemia, glucose in urine, glucose tolerance reduction and insulin release test are unusual, clinical manifestation is a polydipsia, polyphagia, polyuria, excessive thirst, easily hungry, become thin, symptoms such as fatigue and weak, diabetics is because inherited genetic factors, environmental factors, life factor, Nervous and Mental Factors, cause the immune function of human body obstacle, cause the reactive increase of interleukin, promote islet cells endolymph cellular infiltration, the cell that soaks into produces a kind of antagonism insulin function infringement factor lymph and lives plain, the lymph plain beta Cell of islet blood circulation that hinders alive, kill and wound beta Cell of islet and sugar carrier gene, destroy insulin secretion, each link of draining and transporting, cause the infringement of islet function, cause diabetes and diabetic complication.Type 2 diabetes mellitus was called non-insulin-dependent diabetes mellitus in the past, accounted for 90% of diabetic sum, and the age of onset majority is after 35 years old.The medicine of existing this kind of treatment disease is multiple, comprises Chinese medicine and Western medicine, form single, unsatisfactory curative effect.

Summary of the invention

The present invention for the medicine that solves the treatment type 2 diabetes mellitus that exists in the prior art form single, the problem of weak effect and a kind of medicine for the treatment of type 2 diabetes mellitus is provided.

The present invention is realized that by following technical scheme the medicine of treatment type 2 diabetes mellitus is made up of the medicine of following weight ratio example:

12～30 parts of 25～40 parts of Radix Ginsengs of 15～30 portions of Semen Coiciss of 25～40 parts of Stigma Maydis of Radix Rehmanniae

25～40 parts of 20～30 parts of Herba Epimedii of 6～12 parts of Fructus Corni of 25～35 portions of Radix Glycyrrhizaes of Radix Salviae Miltiorrhizae

25～35 parts of 25～35 parts of Radix Polygoni Multiflori of 6～15 portions of Radix Paeoniae Albas of 20～30 parts of Radix Puerariaes of Radix Boehmeriae

The Radix Astragali 3.5～4.5 parts of 20～35 parts of gliclazide of 25～34 parts of Pancreas Sus domestica (diamicron)

Stigma Maydis, diuresis expels the heat-evil, suppressing the hyperactive liver, function of gallbladder promoting.The treatment oedema due to nephritis, beriberi, icterohepatitis, hypertension, cholecystitis, cholelithiasis, diabetes, hematemesis and epistaxis, nasal sinusitis, acute mastitis.

Semen Coicis, strengthening the spleen and tonifying the lung, clearing away heat-damp and promoting diuresis.Treatment is had loose bowels, arthralgia chiefly caused by damp pathogen, the contracture of muscle arteries and veins, joint stuffiness, edema, beriberi, consumptive lung disease, lung abscess, acute appendicitis, stranguria with turbid discharge, leucorrhea.

Radix Ginseng, strongly invigorating primordial QI promotes the production of body fluid admittedly take off, and calms the nerves, and the treatment impairment caused by overstrain is deficient, lack of appetite, asthenia, food is told in regurgitation, the stool lingering diarrhea, and empty cough with asthma is short, the spontaneous perspiration sudden collapse, palpitation with fear, forgetful, dizziness and headache, sexual impotence, frequent micturition is quenched one's thirst, woman uterine bleeding, children's's intermittent infantile convulsion, and prolonged deficiency is not multiple, the disease of all qi-blood-body fluid deficiencies.

Radix Salviae Miltiorrhizae, activating blood and removing stasis, calming heart and tranquilizing mind, evacuation of pus, pain relieving.The treatment angina pectoris, menoxenia, dysmenorrhea, the metrorrhagia leukorrhagia gathers silt, hemoperitoneum pain arthralgia, palpitation with fear sleeplessness, malignant boil toxic swelling.

Radix Glycyrrhizae and middle emergency, lung moistening, detoxifcation, coordinating the actions of various ingredients in a prescription is controlled weakness of the spleen and stomach, lack of appetite, stomachache loose stool, overstrain heating, consumptive lung disease cough, cardiopalmus; Give birth to usefulness, the treatment laryngopharynx swelling and pain, peptic ulcer, ulcer sores is separated poison of drug and alimentary toxicosis.

Fructus Corni, invigorating the liver and kidney, Gu arresting seminal emission gas is collapse.The treatment soreness of the waist and knees, dizzy, tinnitus, sexual impotence, seminal emission, frequent micturition, deficiency of the liver cold and heat, incessant sweating due to debility, psychological treatment scattered pulse.

Herba Epimedii, kidney invigorating and YANG supporting, expelling wind and removing dampness, the treatment sexual impotence, dribbling urination, the muscles and bones contraction is anxious, hemiplegia, weakness of the waist and knees, rheumatic arthralgia, extremity are meciless.

Pancreas Sus domestica, the lung benefiting spleen reinforcing is moisturized.The treatment lung decreases cough, spitting of blood, pulmonary distension dyspnea with rapid respiration, insufficiency of the spleen dysentery, galactostasis, rhagadia manus et pedis.And people's islet function there is certain promotion.

Radix Boehmeriae, the pathogenic fire reducing heat clearing away, the relieving restlessness YIN nourishing is quenched one's thirst, and good hypoglycemic activity is arranged.

Radix Puerariae, the yang invigorating expelling pathogenic factors from muscles, rash antidiarrheal, relieving restlessness is quenched the thirst.It is cold to cure the wound, steady heat headache stiffness of the nape, and dysphoria with smothery sensation is quenched one's thirst, and has loose bowels dysentery, hypertension, angina pectoris, deafness.

The Radix Paeoniae Alba (medicine), nourishing blood to suppress the hyperactive liver, slow middle pain relieving, yin fluid astringing is received antiperspirant.The treatment breast abdomen pain over the hypochondriac region, dysentery stomachache, spontaneous sweating, fever due to yin deficiency, menoxenia, bleeding not during menses.

The Radix Polygoni Multiflori the liver and the kidney tonifying nourishes blood, and dispels the wind.Control both liver and kidney deficiency, sending out must be early white, the blood deficiency dizziness, and waist knee joint weakness, muscles and bones is ached, seminal emission, metrorrhagia and leukorrhagia, chronic malaria, chronic dysentery, chronic hepatitis, carbuncle, hemorrhoidal hamorrhage, haemorrhoids.The Radix Astragali is given birth to and is defended consolidating superficial resistance with benefit, inducing diuresis to remove edema, and detoxification, granulation promoting is controlled spontaneous perspiration, steals and hinders, and arthralgia due to stagnation of blood, edema, carbuncle are not burst or are burst and do not hold back for a long time.

Gliclazide 3.5～4.5 parts (diamicron) is a kind of insulin secretagogue agent, and it strengthens the physiological reaction of beta Cell of islet to glucose, and too high blood glucose is descended.

Said medicine is mutually promoted, and benefiting QI and nourishing blood is arranged, the heat clearing away of invigorating blood circulation, and the effect of promoting the production of body fluid to quench thirst, the present invention can also reduce the absorption of intestinal to cholesterol, reduces serum cholesterol, postpones the generation of albuminuria and hypercholesterolemia, has reduced the complication sickness rate.

The present invention is used in combination traditional Chinese medicine and Western medicine gliclazide, can activate the β cell, avoids the β cell to continue damage, increases the β cell to the secretion of insulin amount, has fundamentally reduced blood glucose, the disease controlling development; Chinese medicine and western medicine has reduced the oral dose of Western medicine in conjunction with treating both the principal and secondary aspects of a disease, and the side effect of Western medicine also decreases, and has reduced the damage to Liver and kidney; Dialectical opinion by Chinese medicine is controlled, and has solved single insoluble problem of Western medicine of using, and is weak as thirsty, suffers from a deficiency of the kidney etc., also solved single Chinese medicine blood sugar lowering of using simultaneously and has been not so good as Western medicine problem efficiently.Chinese medicine and western medicine is used in combination, and can reach mutual supplement with each other's advantages.

The present invention is through 100 clinical patients result of use evaluation tables

Model case

1, Zhang, woman, 39 years old, suffered from type 2 diabetes mellitus 4 months, polyphagia, many dung through checking, thirst and drinking is become thin, glucose in urine (++ ++), fasting glucose 11.5mmol/L is not healed through therapeutic effect several times, changes and takes medicine of the present invention after 3 months, glucose in urine (-), fasting glucose 5.6mmol/L, all diseases disappear, weight increase continues to take and keeps 6 months, and drug withdrawal is not seen recurrence after half a year.

2, the summer, man, 62 years old, workman.Patient's thirst and liking drink, bulimia, polyuria were become thin 2 years, and nearly January is very thirsty, the many happiness drinks of food, frequent micturition muddiness, fatigue and weakness, the lazy speech of breathing hard, extremity are not warm, the numbness of aching, light red tongue is white and moist behind the tongue, venation is dark red at the bottom of the tongue, stringy and thready pulse, the sugar that has urine examined (+++), fasting glucose 14.6mmol/L, through taking medicine of the present invention after 5 months, fasting glucose concentration maintains 5.5mmol/L, and sb.'s illness took a favorable turn, dosage reduces gradually, drug withdrawal after 1 year, and the health that only is careful in one's diet is as before.

3, Korea Spro, the woman, 48 years old, be engaged in agriculture, polydipsia closely over the past half year, polyuria, polyphagia, emaciated physique, soreness of the waist and knees, the dry pharynx dryness of the tongue, feverish sensation in the palms and soles, the time weak breathing hard, aversion to cold and cold limbs, deep red tongue arranged.Yellow fur is done, deep and stringy pulse and counting.Diagnosis, diabetes, glucose in urine (++ ++), fasting glucose 10.55mmol/L, oral medicine is after 13 months, and fasting glucose is stabilized in 5.5mmol/L, transference cure, the glucose in urine feminine gender, the tongue arteries and veins is normal, and its dose reduces gradually, and drug withdrawal is visited after 1 year and is not seen recurrence.

4, Liu, man 63 years old, cadre, patient's excessive thirst, polydipsia, polyuria, tired 1 year surplus, open when making, self-induction is thirsty, and drinking-water increases, the frequency of urinating, the few tongue of red tongue, stringy and thready pulse and sliding, the sugar (++ ++) that has urine examined, after 15 months, dosage reduces blood glucose 15.4mmol/L (on an empty stomach) gradually through oral preparation of the present invention, drug withdrawal after 18 months, fasting glucose are stabilized in all symptoms of 5.7mmol/L glucose in urine (-) and take a turn for the better, follow up a case by regular visits to 1 year all right.

5, Chen, man 52 years old, workman.Patient's body constitution is plump, and is previously healthy, and unexpected xerostomia is thought drink before month, though crapulence does not quench one's thirst, 4 thermos flasks of intaking round the clock, frequency of micturition, rapid digestion of food and polyorexia, body tired god wither, and is diagnosed as type 2 diabetes mellitus at county hospital, glucose in urine (++ ++), fasting glucose 17.7mmol/L once took Western medicine such as insoral and did not have significant reaction, come to go to a doctor, examine the pulse being large and floating, the few tongue of red tongue was taken preparation of the present invention after 25 months, glucose in urine (+), fasting glucose is reduced to 8.7mmol/L, and inflow is reduced to 2 bottles, and spirit takes a turn for the better, after advising it to continue to take 8 months, the glucose in urine feminine gender, glucostasis is almost recovered in 5.5mmol/L (on an empty stomach) disease, follows up a case by regular visits to after the drug withdrawal and does not have recurrence.

The specific embodiment

Embodiment 1: a kind of medicine for the treatment of type 2 diabetes mellitus, and according to the following ratio weighting raw materials thing of every part 1 gram

35 parts of 30 parts of Radix Salviae Miltiorrhizaes of 40 parts of Radix Ginsengs of 15 portions of Semen Coiciss of 25 parts of Stigma Maydis of Radix Rehmanniae

6 parts of 30 parts of Radix Puerariaes of 25 parts of Radix Boehmeriaes of 30 parts of Herba Epimedii of 12 parts of Fructus Corni of Radix Glycyrrhizae

35 parts of 34 parts of Pancreas Sus domestica of 25 parts of Radixs Astragali of 25 parts of Radix Polygoni Multiflori of the Radix Paeoniae Alba

4.5 parts of gliclazide (diamicron)

Said medicine is pulverized, made capsule and can take, wherein gliclazide content is at 5～6 milligrams/.

Embodiment 2: a kind of medicine for the treatment of type 2 diabetes mellitus, form by the medicine of following weight ratio example: and according to the following ratio weighting raw materials thing of every part 1 gram,

25 parts of 12 parts of Radix Salviae Miltiorrhizaes of 40 parts of Radix Ginsengs of 30 portions of Semen Coiciss of 40 parts of Stigma Maydis of Radix Rehmanniae

20 parts of 40 parts of Radix Boehmeriaes of 20 parts of Herba Epimedii of 6 parts of Fructus Corni of Radix Glycyrrhizae

20 parts of 25 parts of Pancreas Sus domestica of 35 parts of Radixs Astragali of 35 parts of Radix Polygoni Multiflori of 15 portions of Radix Paeoniae Albas of Radix Puerariae

3.5 parts of gliclazide (diamicron)

Embodiment 3: a kind of medicine for the treatment of type 2 diabetes mellitus, and according to the following ratio weighting raw materials thing of every part 1 gram,

30 parts of 20 parts of Radix Salviae Miltiorrhizaes of 40 parts of Radix Ginsengs of 25 portions of Semen Coiciss of 30 parts of Stigma Maydis of Radix Rehmanniae

10 parts of 30 parts of Radix Puerariaes of 25 parts of Radix Boehmeriaes of 25 parts of Herba Epimedii of 6 parts of Fructus Corni of Radix Glycyrrhizae

30 parts of 34 parts of Pancreas Sus domestica of 25 parts of Radixs Astragali of 30 parts of Radix Polygoni Multiflori of the Radix Paeoniae Alba

4 parts of gliclazide (diamicron)

Manufacture method is with embodiment 1.

Embodiment 4: a kind of medicine for the treatment of type 2 diabetes mellitus, and according to the following ratio weighting raw materials thing of every part 1 gram,

35 parts of 12 parts of Radix Salviae Miltiorrhizaes of 30 parts of Radix Ginsengs of 30 portions of Semen Coiciss of 25 parts of Stigma Maydis of Radix Rehmanniae

15 parts of 25 parts of Radix Puerariaes of 30 parts of Radix Boehmeriaes of 20 parts of Herba Epimedii of 9 parts of Fructus Corni of Radix Glycyrrhizae

35 parts of 30 parts of Pancreas Sus domestica of 30 parts of Radixs Astragali of 25 parts of Radix Polygoni Multiflori of the Radix Paeoniae Alba

4.5 parts of gliclazide (diamicron)

Manufacture method is with embodiment 1.

Claims (1)

1, a kind of medicine for the treatment of type 2 diabetes mellitus, it is characterized in that: the medicine by the following weight ratio example is formed:

12～30 parts of 25～40 parts of Radix Ginsengs of 15～30 portions of Semen Coiciss of 25～40 parts of Stigma Maydis of Radix Rehmanniae

25～40 parts of 20～30 parts of Herba Epimedii of 6～12 parts of Fructus Corni of 25～35 portions of Radix Glycyrrhizaes of Radix Salviae Miltiorrhizae

25～35 parts of 25～35 parts of Radix Polygoni Multiflori of 6～15 portions of Radix Paeoniae Albas of 20～30 parts of Radix Puerariaes of Radix Boehmeriae

3.5～4.5 parts of 20～35 parts of gliclazide of 25～34 parts of Pancreas Sus domestica of the Radix Astragali.