CN1943758B - A Chinese traditional medicinal composition for treatment of rheumatism and its preparation method - Google Patents
A Chinese traditional medicinal composition for treatment of rheumatism and its preparation method Download PDFInfo
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Abstract
A Chinese traditional medicine composition used in treatment of rheumatism, comprising cortex phellodendri chinsis, rhizoma atractylodis, radix et rhizoma clematidis, caulis spatholobi, nidus vespae, zaocys, bungarus parvus, agkistrodon, flos carthami, eupolyphaga seu steleophaga, myrrha, olibanum, radix angelicae pubescentis, scorpio, scolopendra, pheretima, rhizoma et radix notopterygii, ramulus cinnamomi, rhizoma curcumae longae, etc, used in the treatment of rheumatism in clinic. In addition, the invention discloses the preparation method of the Chinese traditional medicine composition.
Description
Technical field
The present invention relates to rheumatismal Chinese medicine composition of a kind of treatment and preparation method thereof, belong to the field of Chinese medicines.
Background technology
Rheumatic arthritis is the modal a kind of clinical manifestation of rheumatic fever, and is relevant with the allergy that A group hemolytic streptococcal infection causes.Its period of disease mainly shows as local joint to be had significantly red, swollen, hot, pain and touches a tender spot, and painful migratory pain is migration.Rheumatoid arthritis is to involve the multiarticulate chronic inflammation disease of symmetry that the little joint of periphery is the master, its cause of disease and definite pathogeny are not understood as yet, research at present thinks that T, B cellular immune function are one of main pathogenesis of primary disease unusually, and the activation of T, bone-marrow-derived lymphocyte and propagation play an important role in the pathological process of primary disease.
Be rheumatic arthralgia by its caused arthralgia pain, because its pain stage of attack is long, and migratory pain, brought great inconvenience to people's life.Its morbidity system is by caused by liver and kidney deficiency, and muscles and bones mistake is supported, and the wind-cold damp pathogen invasion and attack due to the expectorant stasis of blood stagnation of QI, belong to the deficiency in origin and excess in superficiality card.Treatment is held concurrently with blood circulation promoting and blood stasis dispelling channels sootheing and network vessel quickening, expelling wind and removing dampness, invigorating the spleen for dissipating phlegm based on liver and kidney tonifying.
In " numbness disease " category, " numbness " is the obstructed meaning of impatency to the traditional Chinese medical science with the rheumatic arthritis subordination.Arthromyodynia is meant when the human righteousness is not enough, outward by pathogens such as wind and cold is wet invasion and attack, interiorly causes the passages through which vital energy circulates impatency by expectorant, the stasis of blood, pyretic toxicity, and it is not smooth to cause QI-blood circulation, so see diseases such as arthralgia, stiff, joint stuffiness, moving obstacle.The traditional Chinese medical science is thought the cause of disease " sick from wind " of rheumatism, and therefore, the used medicine of prescription is put in poison at wind mostly.At mentioned above principle, there is the person to use medicines such as clearing away heat-damp and promoting diuresis, removing obstruction in the collateral to relieve pain, QI invigorating be eliminating evil to make up, obtain a kind of Chinese medicine composition: and carry out prescription according to theory of Chinese medical science, as principal agent dispel the wind eliminating cold-damp, warm spleen the kidney invigorating, the effect that rheumatalgia, splenalgia joint aches is had analgesia, all the other medicines have easypro through invigorating blood circulation effects such as heat-clearing and toxic substances removing.It is carried out pharmacodynamics test, and obtained effect preferably.
Summary of the invention
One object of the present invention is to provide a kind of to be had dampness and dispels the wind, blood circulation promoting and blood stasis dispelling, and the removing obstruction in the collateral to relieve pain effect is used for the Chinese medicine composition of rheumatic pain killing;
Another object of the present invention is to provide the preparation method of above-mentioned Chinese medicine composition.
The object of the present invention is achieved like this, according to the Chinese medicine and pharmacy theory, utilize the property of medicine of medical herbs uniqueness, adopt Cortex Phellodendri, Rhizoma Atractylodis, Radix Clematidis, Caulis Spatholobi, Nidus Vespae, Zaocys, Bungarus Parvus, Agkistrodon, Flos Carthami, Eupolyphaga Seu Steleophaga, Myrrha, Olibanum, Radix Angelicae Pubescentis, Scorpio, Scolopendra, Pheretima, Rhizoma Et Radix Notopterygii, Ramulus Cinnamomi, Rhizoma Curcumae Longae, according to certain compatibility requirement, process through special process.
The crude drug of preparation pharmaceutical composition of the present invention is formed and proportioning following (by weight):
40～120 parts of Cortex Phellodendris, 40～120 parts of Rhizoma Atractylodis, 30～90 parts of Radix Clematidis, 40～120 parts of Caulis Spatholobis, 20～60 parts in Nidus Vespae, 30～90 parts of Zaocyss, 15～45 parts of Bungarus Parvus, 10～30 parts of Agkistrodons, 5～15 parts on Flos Carthami, 5～10 parts of Eupolyphaga Seu Steleophagas, 10～30 parts of Myrrhas, 10～30 parts of Olibanums, 10～30 parts of Radix Angelicae Pubescentiss, 10～30 parts of Scorpios, 5～15 parts of Scolopendras, 10～30 parts of Pheretimas, 10～30 parts of Rhizoma Et Radix Notopterygiis, 5～15 parts of Ramulus Cinnamomi, 5～15 parts in Rhizoma Curcumae Longae.
The crude drug of pharmaceutical composition of the present invention is formed best proportioning and is (by weight):
78.0 parts of Cortex Phellodendris, 78.3 parts of Rhizoma Atractylodis, 58.6 parts of Radix Clematidis, 78.0 parts of Caulis Spatholobis, 38.8 parts in Nidus Vespae, 58.0 parts of Zaocyss, 27.0 parts of Bungarus Parvus, 18.7 parts of Agkistrodons, 11.6 parts on Flos Carthami, 7.5 parts of Eupolyphaga Seu Steleophagas, 18.8 parts of Myrrhas, 18.8 parts of Olibanums, 19.6 parts of Radix Angelicae Pubescentiss, 18.7 parts of Scorpios, 11.5 parts of Scolopendras, 20.0 parts of Pheretimas, 19.6 parts of Rhizoma Et Radix Notopterygiis, 10.0 parts of Ramulus Cinnamomi, 12.0 parts in Rhizoma Curcumae Longae.
Used Olibanum among the present invention, Myrrha with the parch method obtain for good.
Chinese medicine composition among the present invention can be used for clinical dosage forms commonly used such as pill, tablet, capsule.
The preparation technology of the Chinese medicine composition among the present invention is as follows:
19 flavors of writing out a prescription are got Rhizoma Atractylodis, that Rhizoma Curcumae Longae adds water is moistening, and after running through, vapor distillation 4～8 hours extracts volatile oil, and volatilization fluid carries out a rectification again, and rectification volatile oil is standby.Rhizoma Atractylodis, Rhizoma Curcumae Longae medicinal residues and Cortex Phellodendri, Caulis Spatholobi, Rhizoma Et Radix Notopterygii, Radix Clematidis four flavors decoct with water 2～4 times, amount of water is 6～12 times, time was followed successively by 0.5～3 hour, filter, merging filtrate, aqueous solution after adding Rhizoma Atractylodis, the Rhizoma Curcumae Longae distillation is concentrated into relative density and is the extractum of 1.20～1.40 (60-70 ℃), and is standby.13 flavors such as all the other Bungarus Parvus are pulverized, and sieve, and are standby, get the crude drug dried bean noodles and mixed 20～60 minutes, add above-mentioned standby stream extractum wet mixing 20～60 minutes again, mixing, granulate, drying, granulate sprays into volatile oil, moistening, add adjuvant, make acceptable dosage form clinically, as: pill, tablet, capsule etc.
Chinese medicine composition institute preferable preparation technique among the present invention is:
19 flavors of writing out a prescription are got Rhizoma Atractylodis, that Rhizoma Curcumae Longae adds water is moistening, and after running through, steam distilled 6 hours, extracted volatile oil, and volatilization fluid carries out a rectification again, and rectification volatile oil is standby.Rhizoma Atractylodis, Rhizoma Curcumae Longae medicinal residues and Cortex Phellodendri, Caulis Spatholobi, Rhizoma Et Radix Notopterygii, Radix Clematidis four flavors decoct with water three times, amount of water is followed successively by 10,8,8 times, time was followed successively by 2,1.5,1 hours, filter, merging filtrate, aqueous solution after adding Rhizoma Atractylodis, the Rhizoma Curcumae Longae distillation is concentrated into relative density and is the extractum of 1.30 (60-70 ℃), and is standby.13 flavors such as all the other Bungarus Parvus are pulverized, and sieve, and are standby, get the crude drug dried bean noodles and mix 30 minutes, add above-mentioned standby stream extractum wet mixing 30 minutes again, and mixing is granulated, drying, and granulate sprays into volatile oil, and moistening adds adjuvant, makes preparation.
Chinese medicine composition among the present invention is mainly used in the application in the treatment rheumatism.
The inventor of medicine of the present invention is aspect the selection and compatibility thereof of crude drug, carried out series of experiment research, determine the crude drug composition of preparation medicine of the present invention, made it compared with prior art have significantly outstanding curative effect advantage, realized the potentiation purpose of compatible combination.
Following experimental example further specifies the medical application of medicine of the present invention by observing the curative effect of this traditional Chinese medicine composition for treating curing rheumatic disease.
The experimental study of test one, medicine of the present invention analgesia (the mice hot plate causes pain) effect
1, material
Male white mouse, body weight 18～22g is provided by Shandong University's Experimental Animal Center.Animal credit number: SCXK-2003-020.
Medicine: medicine concentrated solution of the present invention (high concentration 2.38g/ml, middle concentration 1.25g/ml, low concentration 0.59g/ml); Ibuprofen (0.0065g/ml, lot number: 030826); Normal saline.
2, test method
Regulate the thermostat water bath water temperature and be (55 ± 0.5) ℃, preheating 10min; Put 1 mice at every turn to hot plate, pick up counting simultaneously, metapedes required time (s) appears licking in record, selects 30s to do the back experiment with the interior mice that licks metapedes.
Qualified mice is divided into 5 groups at random, every group each 10, is grouped as follows: (1) blank group: oral normal saline 15ml/kg; (2) positive controls: oral ibuprofen 0.0105g/kg; (3)～(5) the high, medium and low dosage group of medicine of the present invention: oral medicine 40.500g/kg of the present invention respectively, 20.250g/kg, 10.125g/kg.Above-mentioned each group difference administration three days.
3, result
After the administration in the 4th day, the pain threshold behind measurement 15min and the 30min.Surpass the note 60s that 60s does not still lick metapedes.What record the results are shown in Table 1:
Table 1 medicine of the present invention causes the influence (x ± s) of pain to the mice hot plate method
Annotate: 1. compare P＜0.01 with the blank group; 2. compare P＜0.05 with the blank group.
4, conclusion
The above results shows that the pain that medicine of the present invention is caused by hot plate method for mice has good analgesic effect.The analgesic effect that shows medicine of the present invention is good.
Test two, medicine of the present invention are to the rat paw edema experimental study
1, material
The healthy SD rat, the cleaning level, male, body weight 250～320g is provided by Shandong University's animal center.
Be subjected to the reagent thing: medicine of the present invention, make the concentrated solution of 1.32g crude drug/ml.
2, test method
Rat is divided into 5 groups at random, 8 every group: normal saline matched group, YUANHU ZHITONG PIAN group (700mg/kg), aspirin group (100mg/kg), acesodyne capsule A group (1000mg/kg), acesodyne capsule B organize (500mg/kg).1 time/d of gastric infusion is 3d altogether.
Test as follows: be used for the branch chi before the administration and measure every the normal left hind foot of Mus sole of the foot thickness,, gavage ordinary water by 6ml/100g simultaneously as normal value.And from left hind foot sole of the foot middle part subcutaneous injection 10% Ovum Gallus domesticus album aqueous solution 0.1ml/ only, administration subsequently.Each group is all surveyed its sufficient sole of the foot thickness behind medication 0.5,1,2,3h, obtain every group of foot swelling percentage rate at last.Calculate the swelling rate.The results are shown in Table 2.
3, result of the test
Table 2 medicine of the present invention is to the influence of rat paw edema due to the Ovum Gallus domesticus album (n=10, x ± s)
Annotate: compare * P＜0.05, * * P＜0.01, * * * P＜0.001 with the normal saline group
The result shows, 2 dosage groups of medicine of the present invention have the obvious suppression effect to the right back foot of rat due to the Ovum Gallus domesticus album apart from swelling, and all are better than the inhibition effect of aspirin.As seen the Chinese medicine composition in this is stronger to the antiinflammatory action of tentative animal, and curative effect is obvious.
The acute toxicity test research of test three, medicine of the present invention
1, material
Kunming mouse, male and female half and half.Provide by Shandong University experimental animal center.
Be subjected to the reagent thing: medicine of the present invention, making can be for the Cmax of mouse stomach (3.56g crude drug/ml).
2, test method
40 of mices are divided into 2 groups, male and female half and half at random.The administration group: medicine (irritate the preceding fasting of stomach and can't help water 14h, and conventional the raising observed 7 days after the administration by 3.56g crude drug/ml), once irritate stomach 0.8ml/20g body weight; Matched group: irritate stomach equivalent drinking water, all the other are with the administration group.
Before the administration and after the administration the 1st, 3,5,7 day surveyed mice appetite and body weight respectively, and data represent with x ± s, the results are shown in Table 3, table 4.
3, result
Table 3 medicine acute toxicity test of the present invention mice body weight change (g, x ± s, n=10)
Annotate: compare * P＜0.05 with matched group
The variation of table 4 medicine acute toxicity test of the present invention mice food ration (g, x ± s,, n=20)
Annotate: compare △ P＜0.01, * P＜0.05 with matched group
Above-mentioned result of the test shows that to behind the mouse stomach medicine of the present invention, it is little that its body weight and food ration change difference, abnormal phenomena do not occur.As seen the toxicity of medicine of the present invention is little, can be used for clinical.
The specific embodiment
The present invention is further illustrated below in conjunction with embodiment, and following this embodiment only is used to the present invention is described and to the present invention without limits.
Embodiment 1:
Prescription: Cortex Phellodendri 78.0g Rhizoma Atractylodis 78.3g Radix Clematidis 58.6g Caulis Spatholobi 78.0g
Nidus Vespae 38.8g Zaocys 58.0g Bungarus Parvus 27.0g Agkistrodon 18.7g
Flos Carthami 11.6g Eupolyphaga Seu Steleophaga 7.5g Myrrha (stir-fry) 18.8g Olibanum (stir-fry) 18.8g
Radix Angelicae Pubescentis 19.6g Scorpio 18.7g Scolopendra 11.5g Pheretima 20.0g
Rhizoma Et Radix Notopterygii 19.6g Ramulus Cinnamomi 10.0g Rhizoma Curcumae Longae 12.0g
Method for making: above 19 flavors, get Rhizoma Atractylodis, that Rhizoma Curcumae Longae adds water is moistening, after running through, steam distill 6 hours, extracted volatile oil, and the fluid that volatilizees carries out a rectification again, and rectification volatile oil is standby.Rhizoma Atractylodis, Rhizoma Curcumae Longae medicinal residues and Cortex Phellodendri, Caulis Spatholobi, Rhizoma Et Radix Notopterygii, Radix Clematidis four flavors decoct with water three times, amount of water is followed successively by 10,8,8 times, time was followed successively by 2,1.5,1 hours, filter, merging filtrate, aqueous solution after adding Rhizoma Atractylodis, the Rhizoma Curcumae Longae distillation is concentrated into relative density and is the extractum of 1.30 (60-70 ℃), and is standby.13 flavors such as all the other Bungarus Parvus are pulverized, and sieve, and are standby, get the crude drug dried bean noodles and mix 30 minutes, add above-mentioned standby stream extractum wet mixing 30 minutes again, and mixing is granulated, drying, and granulate sprays into volatile oil, moistening, packing is made 1000, promptly.
Embodiment 2:
Prescription: Cortex Phellodendri 78.0g Rhizoma Atractylodis 78.3g Radix Clematidis 58.6g Caulis Spatholobi 78.0g
Nidus Vespae 38.8g Zaocys 58.0g Bungarus Parvus 27.0g Agkistrodon 18.7g
Flos Carthami 11.6g Eupolyphaga Seu Steleophaga 7.5g Myrrha (stir-fry) 18.8g Olibanum (stir-fry) 18.8g
Radix Angelicae Pubescentis 19.6g Scorpio 18.7g Scolopendra 11.5g Pheretima 20.0g
Rhizoma Et Radix Notopterygii 19.6g Ramulus Cinnamomi 10.0g Rhizoma Curcumae Longae 12.0g
Method for making: above 19 flavors, get Rhizoma Atractylodis, that Rhizoma Curcumae Longae adds water is moistening, after running through, steam distill 6 hours, extracted volatile oil, and the fluid that volatilizees carries out a rectification again, and rectification volatile oil is standby.Rhizoma Atractylodis, Rhizoma Curcumae Longae medicinal residues and Cortex Phellodendri, Caulis Spatholobi, Rhizoma Et Radix Notopterygii, Radix Clematidis four flavors decoct with water three times, amount of water is followed successively by 10,8,8 times, time was followed successively by 2,1.5,1 hours, filter, merging filtrate, aqueous solution after adding Rhizoma Atractylodis, the Rhizoma Curcumae Longae distillation is concentrated into relative density and is the extractum of 1.30 (60-70 ℃), and is standby.13 flavors such as all the other Bungarus Parvus are pulverized, and sieve, and are standby, get the crude drug dried bean noodles and mixed 30 minutes, add above-mentioned standby stream extractum wet mixing 30 minutes again, mixing, granulate drying, granulate, spray into volatile oil, moistening, it is an amount of to add starch, add 4% carboxymethylstach sodium and 10% microcrystalline Cellulose again, mix homogeneously is with 85% alcohol granulation, add a small amount of magnesium stearate, granulate is pressed into 1000.
Embodiment 3:
Prescription: Cortex Phellodendri 78.0g Rhizoma Atractylodis 78.3g Radix Clematidis 58.6g Caulis Spatholobi 78.0g
Nidus Vespae 38.8g Zaocys 58.0g Bungarus Parvus 27.0g Agkistrodon 18.7g
Flos Carthami 11.6g Eupolyphaga Seu Steleophaga 7.5g Myrrha (stir-fry) 18.8g Olibanum (stir-fry) 18.8g
Radix Angelicae Pubescentis 19.6g Scorpio 18.7g Scolopendra 11.5g Pheretima 20.0g
Rhizoma Et Radix Notopterygii 19.6g Ramulus Cinnamomi 10.0g Rhizoma Curcumae Longae 12.0g
Method for making: above 19 flavors, get Rhizoma Atractylodis, that Rhizoma Curcumae Longae adds water is moistening, after running through, steam distill 6 hours, extracted volatile oil, and the fluid that volatilizees carries out a rectification again, and rectification volatile oil is standby.Rhizoma Atractylodis, Rhizoma Curcumae Longae medicinal residues and Cortex Phellodendri, Caulis Spatholobi, Rhizoma Et Radix Notopterygii, Radix Clematidis four flavors decoct with water three times, amount of water is followed successively by 10,8,8 times, time was followed successively by 2,1.5,1 hours, filter, merging filtrate, aqueous solution after adding Rhizoma Atractylodis, the Rhizoma Curcumae Longae distillation is concentrated into relative density and is the extractum of 1.30 (60-70 ℃), and is standby.13 flavors such as all the other Bungarus Parvus are pulverized, and sieve, and are standby, get the crude drug dried bean noodles and mix 30 minutes, add above-mentioned standby stream extractum wet mixing 30 minutes again, mixing is granulated, drying, granulate sprays into volatile oil, moistening adds microcrystalline Cellulose 200g, adds starch to total amount 1000g, mixing, the system soft material is pressed into ball, drying, packing, promptly.
Claims (6)
1. rheumatismal Chinese medicine composition of treatment is characterized in that this Chinese medicine composition made by following raw material medicaments:
40～120 parts of Cortex Phellodendris, 40～120 parts of Rhizoma Atractylodis, 30～90 parts of Radix Clematidis, 40～120 parts of Caulis Spatholobis, 20～60 parts in Nidus Vespae, 30～90 parts of Zaocyss, 15～45 parts of Bungarus Parvus, 10～30 parts of Agkistrodons, 5～15 parts on Flos Carthami, 5～10 parts of Eupolyphaga Seu Steleophagas, 10～30 parts of Myrrhas, 10～30 parts of Olibanums, 10～30 parts of Radix Angelicae Pubescentiss, 10～30 parts of Scorpios, 5～15 parts of Scolopendras, 10～30 parts of Pheretimas, 10～30 parts of Rhizoma Et Radix Notopterygiis, 5～15 parts of Ramulus Cinnamomi, 5～15 parts in Rhizoma Curcumae Longae.
2. Chinese medicine composition as claimed in claim 1 is characterized in that this Chinese medicine composition made by following raw material medicaments:
78.0 parts of Cortex Phellodendris, 78.3 parts of Rhizoma Atractylodis, 58.6 parts of Radix Clematidis, 78.0 parts of Caulis Spatholobis, 38.8 parts in Nidus Vespae, 58.0 parts of Zaocyss, 27.0 parts of Bungarus Parvus, 18.7 parts of Agkistrodons, 11.6 parts on Flos Carthami, 7.5 parts of Eupolyphaga Seu Steleophagas, 18.8 parts of Myrrhas, 18.8 parts of Olibanums, 19.6 parts of Radix Angelicae Pubescentiss, 18.7 parts of Scorpios, 11.5 parts of Scolopendras, 20.0 parts of Pheretimas, 19.6 parts of Rhizoma Et Radix Notopterygiis, 10.0 parts of Ramulus Cinnamomi, 12.0 parts in Rhizoma Curcumae Longae.
3. Chinese medicine composition as claimed in claim 1 or 2 is characterized in that this Chinese medicine composition makes clinical common formulations, comprises capsule, pill, tablet.
4. as the preparation method of Chinese medicine composition as described in the claim 3, it is characterized in that adopting following method preparation:
More than 19 flavors, get Rhizoma Atractylodis, that Rhizoma Curcumae Longae adds water is moistening, after running through, vapor distillation 4～8 hours extracts volatile oil, volatilization fluid carries out a rectification again, rectification volatile oil is standby.Rhizoma Atractylodis, Rhizoma Curcumae Longae medicinal residues and Cortex Phellodendri, Caulis Spatholobi, Rhizoma Et Radix Notopterygii, Radix Clematidis four flavors decoct with water 2～4 times, amount of water is 6～12 times, time was followed successively by 0.5～3 hour, filter, merging filtrate, add the aqueous solution after Rhizoma Atractylodis, the Rhizoma Curcumae Longae distillation, be concentrated into relative density and be determined as 1.20～1.40 extractum at 60～70 ℃, standby.13 flavors such as all the other Bungarus Parvus are pulverized, and sieve, and are standby, get the crude drug dried bean noodles and mix 20～60 minutes, add above-mentioned standby stream extractum wet mixing 20～60 minutes again, and mixing is granulated, drying, and granulate sprays into volatile oil, and moistening adds conventional adjuvant, makes required dosage form.
5. as the preparation method of Chinese medicine composition as described in the claim 4, it is characterized in that adopting following method preparation:
More than 19 flavors, get Rhizoma Atractylodis, that Rhizoma Curcumae Longae adds water is moistening, after running through, steam distill 6 hours, extracted volatile oil, the fluid that volatilizees carries out a rectification again, rectification volatile oil is standby.Rhizoma Atractylodis, Rhizoma Curcumae Longae medicinal residues and Cortex Phellodendri, Caulis Spatholobi, Rhizoma Et Radix Notopterygii, Radix Clematidis four flavors decoct with water three times, amount of water is followed successively by 10,8,8 times, time was followed successively by 2,1.5,1 hours, filter, merging filtrate, add the aqueous solution after Rhizoma Atractylodis, the Rhizoma Curcumae Longae distillation, be concentrated into relative density and be determined as 1.30 extractum at 60～70 ℃, standby.13 flavors such as all the other Bungarus Parvus are pulverized, and sieve, and are standby, get the crude drug dried bean noodles and mix 30 minutes, add above-mentioned standby stream extractum wet mixing 30 minutes again, and mixing is granulated, drying, and granulate sprays into volatile oil, moistening; Add suitable adjuvant, make required dosage form.
6. Chinese medicine composition as claimed in claim 1 or 2 is used for the treatment of application in the rheumatism medicine in preparation.
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| CN102657825A (en) * | 2012-06-01 | 2012-09-12 | 通化金马药业集团股份有限公司 | Rheumatic pain-relieving medicine used for treating rheumatic arthritis and rheumatoid arthritis and preparation method thereof |
| CN104013929B (en) * | 2012-06-01 | 2015-06-17 | 通化金马药业集团股份有限公司 | Rheumatism pain relief medicine for treating rheumatic arthritis and rheumatoid arthritis and preparation method thereof |
| CN104524181A (en) * | 2014-12-02 | 2015-04-22 | 范影 | Traditional Chinese medicine prescription for treating rheumatism |
| CN109395015B (en) * | 2018-10-25 | 2021-09-07 | 通化金马药业集团股份有限公司 | Application of rheumatism and pain relieving traditional Chinese medicine composition in preparation of anti-angiogenesis medicine |
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| 张永兰.上中下通用痛风方的临床应用.吉林中医药 4.1992,(4),30. |
| 张永兰.上中下通用痛风方的临床应用.吉林中医药 4.1992,(4),30. * |
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