CN1943685A - A giantarum fat-reducing granule containing oligo polyflavanol and preparation method and use - Google Patents
A giantarum fat-reducing granule containing oligo polyflavanol and preparation method and use Download PDFInfo
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- CN1943685A CN1943685A CNA2006101247914A CN200610124791A CN1943685A CN 1943685 A CN1943685 A CN 1943685A CN A2006101247914 A CNA2006101247914 A CN A2006101247914A CN 200610124791 A CN200610124791 A CN 200610124791A CN 1943685 A CN1943685 A CN 1943685A
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Abstract
It is a kind of giantarum fat-reducing granule containing oligo polyflavanol and preparation method. The main point is: the giantarum glycn glucomannan gel granule envelopes oligo flavanol, vitamin E and mineral matters. Its preparing method:put the above raw materials according to the given ratio into the mixer to mix them , and slowly add distilled water 3-30 times by mass of the giantarum glycn glucomannan and stir them until they form into uniformed gelatin, dry the gelatin by reducing pressure in low temperature, then crush and screen them to be 0.1-2mm diameter of fine granules. These can be used as fat-reducing food. The advantage of this invention is that not only the giantarum glycn glucomannan has the fat-reducing effect, but also improved the biologic usage of the oligo flavanol, so to strengtheed the effects of fat-reduction.
Description
Technical field
The invention belongs to a kind of polysaccharide gel fat-reducing granule and preparation method and purposes that contains the natural plants lipase inhibitor, especially contain giantarum fat-reducing granule and the preparation method and the purposes of oligo polyflavanol.
Background technology
How to solve the fat influence that brings to human health rationally and effectively is the important subject that the world of medicine faces.The fat reason that takes place is many-sided, and as inherited genetic factors, environmental factors, dietary habit etc., wherein high fat diet is the major reason that causes fat.In recent years, Drug therapy is one of effective means of treatment of obesity, reaches therapeutic purposes by reducing fat absorption.Pancreas and gastric lipase are that fat digestion absorbs necessary in the intestinal.Fat in the food is absorbed at intestinal after being hydrolyzed to monoacylglycerol and free fatty, and synthctic fat again in vivo causes athero then, finally can cause fat.Use lipase inhibitor and can suppress effectively that lipase reaches the purpose that reduces fat absorption, control and treatment obesity to the decomposition catalytic action of fat in the intestinal.Thereby use effective lipase inhibitor and be subjected to people's attention.
Be used for the treatment of fat lipase inhibitor and be mainly derived from plant extract and microbial fermentation product.The fat-reducing lipase inhibitor that microbial fermentation processes is produced, the existing procucts listing.The most successful example is effective lipase inhibitor lipstatin that Switzerland Roche Holding Ag found from Streptomyces toxytricini in 1987, product orlistat character after its hydrogenation is more stable, activity is stronger, is the main component of street drug Xenical.The report that extract to suppress the lipase active composition from plant is more, as the flavonol dimer in the Herba Cassiae Nomamis etc.; Moreno etc. find that the effective ingredient tool of seed of Fructus Vitis viniferae extracting solution suppresses the activity of people's pancreatic lipase, can be used for treatment of obesity and diabetes, but do not separate the concrete inhibitor composition of purifying as yet.Discovery oleuropeins such as Polzonetti also can be used as the competitive inhibitor of lipase, Ninomiya etc. carry out the bioassay of pancreatic lipase maximum inhibition to separating obtained composition in Salvia japonica Thunb. (Salviaofficinalis L.) leaf, and several abietane type diterpene (carnosic acid, carnosol etc.) that obtain and triterpene (oleanolic acid) all tool suppress active.The lipase inhibitor of these plant origins does not all also well utilize.And be applied to weight losing function food by extracting the oligo polyflavanol that obtains in Folium Nelumbinis or Receptaculum Nelumbinis or Punica granatum L. or the Folium Kaki in the patent, do not appear in the newspapers as yet.
Therefore the problem that often causes the anus leakage of oil during lipase inhibitor is used separately adopts the phenomenon that can reduce the anus leakage of oil with the mixture of polysaccharide, and microbe-derived orlistat was just once adopted and the guar gum mixed pressuring plate, has obtained effect preferably.Yet the selection research to polysaccharide is still very weak, in fact, although the adding of polysaccharide can reduce the anus leakage of oil, may have influence on bioequivalence.The simple mixing of this exo polysaccharides and lipase inhibitor can not be avoided in the possible under one's belt untoward reaction of the composite slimming factor, has guaranteed that the large tracts of land of the weight losing function factor in intestinal absorbs.
Rhizoma amorphophalli is the traditional fat-reducing food materials of China, its fat-reducing effect and safety gain public acceptance already, yet in all researchs in past, the overwhelming majority was all with the form straight forming of the Rhizoma amorphophalli glucomannan of konjaku powder or purification or make beverage during Rhizoma amorphophalli was used as diet food, and discrete processing is treated to low-molecular-weight oligosaccharide with Rhizoma amorphophalli glucomannan.And in fact more studies show that, high molecular or low-molecular-weight polysaccharide all may have influence on its oil absorption and emulsifying capacity.
Summary of the invention
The object of the present invention is to provide a kind of giantarum fat-reducing granule and preparation method and purposes that contains oligo polyflavanol, it can overcome the deficiency of prior art, the Rhizoma amorphophalli glucomannan that adopts specified molecular weight and have a good effect of weight reducing is a substrate, weight losing function factor oligo polyflavanol and nutrient material are carried out embedding, avoid the possible under one's belt untoward reaction of the composite slimming factor, guarantee that the large tracts of land of the weight losing function factor in intestinal absorbs, thereby significantly improve fat-reducing effect.
The technical scheme that realizes the object of the invention is: a kind of giantarum fat-reducing granule that contains oligo polyflavanol is characterized in that: be embedded with oligo polyflavanol and vitamin and mineral in the konjak portuguese gansu polyose gel granule.
And by mass ratio, oligo polyflavanol: vitamin: mineral: Rhizoma amorphophalli glucomannan is 1: 0.5～10: 1～20: 5～100.
And the degree of polymerization scope of contained oligo polyflavanol is 2～6, is that its purity is 20～90% by the natural grease enzyme inhibitor that extracts acquisition in Folium Nelumbinis or Receptaculum Nelumbinis or Punica granatum L. or Folium Kaki or Semen Vitis viniferae or the Herba Cassiae Nomamis.
And contained vitamin is V
A, V
C, V
EIn one or more.
And contained mineral is one or more in calcium, chromium, copper, zinc, ferrum, the magnesium.
And Rhizoma amorphophalli glucomannan is for having molecular weight ranges 5.0 * 10
4～5.0 * 10
5Micropowder.
Second technical scheme that realizes the object of the invention is: the preparation method that contains the giantarum fat-reducing granule of oligo polyflavanol, it is characterized in that: above-mentioned raw materials is mixed in a blender by proportioning, the distilled water and the stirring that slowly add 3～30 times of Rhizoma amorphophalli glucomannan quality, to forming even gel, this gel is further taked to reduce pressure after the cold drying, smashs and sieve out the granule that particle diameter is 0.1～2mm to pieces with bruisher.
The 3rd technical scheme that realizes the object of the invention is: be used for diet food.
And, be pressed into chewable tablet or tablet or record into capsule or as the filling heart of cake.
And, mix to be pressed into milk slice as the additive of beverage or with defatted milk powder etc.
The Rhizoma amorphophalli glucomannan that the present invention adopts specified molecular weight and has a good effect of weight reducing is a substrate, weight losing function factor oligo polyflavanol and nutrient material are carried out embedding, avoided the possible under one's belt untoward reaction of the composite slimming factor, guaranteed that the large tracts of land of the weight losing function factor in intestinal absorbs, and reduces possible anus oil leakage phenomenon.
The present invention has the following advantages:
1. adopt the Rhizoma amorphophalli glucomannan of specified molecular weight, not only itself has effect of weight reducing equally, and has improved the bioavailability of oligo polyflavanol, has strengthened fat-reducing effect.
2. weight losing function factor raw material is in the natural plants and obtains, and safety is better, meets the industry development direction.
3. Zhi Bei feed particulate material applied range both can be made into capsule and tablet, also can add in the food such as beverage, dessert.
The specific embodiment
The invention will be further described below with reference to embodiment.Embodiment provided by the invention based on technical scheme be: a kind of giantarum fat-reducing granule that contains oligo polyflavanol is characterized in that: be embedded with oligo polyflavanol and vitamin and mineral in the konjak portuguese gansu polyose gel granule.
Further technical scheme can be: by mass ratio, oligo polyflavanol: vitamin: mineral: Rhizoma amorphophalli glucomannan is 1: 0.5～10: 1～20: 5～100.
Further technical scheme can also be: the degree of polymerization scope of contained oligo polyflavanol is 2～6, is that its purity is 20～90% by the natural grease enzyme inhibitor that extracts acquisition in Folium Nelumbinis or Receptaculum Nelumbinis or Punica granatum L. or Folium Kaki or Semen Vitis viniferae or the Herba Cassiae Nomamis.
And contained vitamin is V
A, V
C, V
EIn one or more.
And contained mineral is one or more in calcium, chromium, copper, zinc, ferrum, the magnesium.
And Rhizoma amorphophalli glucomannan is for having molecular weight ranges 5.0 * 10
4～5.0 * 10
5Micropowder.
Second technical scheme is: the preparation method that contains the giantarum fat-reducing granule of oligo polyflavanol, it is characterized in that: above-mentioned raw materials is mixed in a blender by proportioning, the distilled water and the stirring that slowly add 3～30 times of Rhizoma amorphophalli glucomannan quality, to forming even gel, this gel further take decompression (＜100mmHg) after low temperature (＜45 ℃) drying, smash and sieve out the granule that particle diameter is 0.1～2mm to pieces with bruisher.
The 3rd technical scheme is: be used for diet food.
Further technical scheme can be: be pressed into chewable tablet or tablet or record into capsule or as the filling heart of cake.
And, mix to be pressed into milk slice as the additive of beverage or with defatted milk powder etc.
Embodiments of the invention are as follows:
Embodiment 1:
| Rhizoma amorphophalli glucomannan | Molecular weight 5.0 * 10 4 | 5Kg |
| Oligo polyflavanol | Purity 90% | 1Kg |
| Calcium | Calcium carbonate | 1Kg |
| Chromium | Pyridine chromium | 0.2g |
| Copper | Copper sulfate | 1.5g |
| Ferrum | Ferrous sulfate | 15g |
| Magnesium | Magnesium sulfate | 0.3Kg |
| Zinc | Zinc sulfate | 20g |
| V C | 1Kg | |
| V A | 2500 million international units | |
| V E | 40 million international units |
Above-mentioned raw materials mixes in a blender, slowly adds the distilled water of 8 times of Rhizoma amorphophalli glucomannan quality and stirs, and to forming even gel, this gel is further taked to reduce pressure after the cold drying, smashs and sieve out the granule of 0.1～2mm to pieces with bruisher.Record 15500 of capsules, Simple Obesity crowd's test-meal, 6 of every days, 4 week back average weight declines 6.2%.
Embodiment 2:
| Rhizoma amorphophalli glucomannan | Molecular weight 5.0 * 10 5 | 10Kg |
| Oligo polyflavanol | Purity 20% | 1Kg |
| Calcium | Calcium carbonate | 1Kg |
| Chromium | Pyridine chromium | 0.2g |
| Ferrum | Ferrous sulfate | 15g |
| Zinc | Zinc sulfate | 20g |
| V C | 1Kg |
Above-mentioned raw materials mixes in a blender, slowly adds the distilled water of 3 times of Rhizoma amorphophalli glucomannan quality and stirs, and to forming even gel, this gel is further taked to reduce pressure after the cold drying, smashs and sieve out the granule of 0.1～2mm to pieces with bruisher.Record 21500 of capsules, Simple Obesity crowd's test-meal, 6 of every days, 4 week back average weight declines 5.8%.
Embodiment 3:
| Rhizoma amorphophalli glucomannan | Molecular weight 2.0 * 10 5 | 20Kg |
| Oligo polyflavanol | Purity 70% | 1Kg |
| Calcium | Calcium carbonate | 1.5Kg |
| Copper | Copper sulfate | 1.5g |
| Ferrum | Ferrous sulfate | 15g |
| Magnesium | Magnesium sulfate | 0.4Kg |
| Zinc | Zinc sulfate | 20g |
| V C | 1Kg | |
| V E | 40 million international units |
Above-mentioned raw materials mixes in a blender, slowly adds the distilled water of 30 times of Rhizoma amorphophalli glucomannan quality and stirs, and to forming even gel, this gel is further taked to reduce pressure after the cold drying, smashs and sieve out the granule of 0.1～2mm to pieces with bruisher.Record 38700 of capsules, Simple Obesity crowd's test-meal, 6 of every days, 4 week back average weight declines 4.1%.
Embodiment 4:
| Rhizoma amorphophalli glucomannan | Molecular weight 2.0 * 10 5 | 12Kg |
| Oligo polyflavanol | Purity 70% | 1Kg |
| Chromium | Pyridine chromium | 0.2g |
| Copper | Copper sulfate | 1.5g |
| Ferrum | Ferrous sulfate | 15g |
| Magnesium | Magnesium sulfate | 0.3Kg |
| Zinc | Zinc sulfate | 20g |
| V C | 1Kg |
Above-mentioned raw materials mixes in a blender, slowly add Rhizoma amorphophalli glucomannan quality 3-30 doubly distilled water and stir, to forming even gel, this gel is further taked to reduce pressure after the cold drying, smashs and sieve out the granule of 0.1～2mm to pieces with bruisher.Record 24600 of capsules, Simple Obesity crowd's test-meal, 6 of every days, 4 week back average weight declines 7.3%.
Embodiment 5:
| Rhizoma amorphophalli glucomannan | Molecular weight 5.0 * 10 4 | 5Kg |
| Oligo polyflavanol | Purity 20% | 1Kg |
| Calcium | Calcium carbonate | 1Kg |
| Chromium | Pyridine chromium | 0.2g |
| Copper | Copper sulfate | 1.5g |
| Ferrum | Ferrous sulfate | 15g |
| Magnesium | Magnesium sulfate | 0.3Kg |
| Zinc | Zinc sulfate | 20g |
| V C | 1Kg |
Above-mentioned raw materials mixes in a blender, slowly adds the distilled water of 8 times of Rhizoma amorphophalli glucomannan quality and stirs, and to forming even gel, this gel is further taked to reduce pressure after the cold drying, smashs and sieve out the granule of 0.1～2mm to pieces with bruisher.Record 15500 of capsules, Simple Obesity crowd's test-meal, 6 of every days, 4 week back average weight declines 4.2%.
Embodiment 6:
| Rhizoma amorphophalli glucomannan | Molecular weight 5.0 * 10 5 | 10Kg |
| Oligo polyflavanol | Purity 90% | 1Kg |
| Calcium | Calcium carbonate | 1Kg |
| Chromium | Pyridine chromium | 0.2g |
| Ferrum | Ferrous sulfate | 15g |
| Zinc | Zinc sulfate | 20g |
| V C | 1Kg |
Above-mentioned raw materials mixes in a blender, slowly adds the distilled water of 3 times of Rhizoma amorphophalli glucomannan quality and stirs, and to forming even gel, this gel is further taked to reduce pressure after the cold drying, smashs and sieve out the granule of 0.1～2mm to pieces with bruisher.Record 21500 of capsules, Simple Obesity crowd's test-meal, 6 of every days, 4 week back average weight declines 7.7%.
Embodiment 7:
| Rhizoma amorphophalli glucomannan | Molecular weight 2.0 * 10 5 | 20Kg |
| Oligo polyflavanol | Purity 20% | 1Kg |
| Calcium | Calcium carbonate | 1.5Kg |
| Copper | Copper sulfate | 1.5g |
| Magnesium | Magnesium sulfate | 0.4Kg |
| Zinc | Zinc sulfate | 20g |
| V C | 1Kg | |
| V E | 40 million international units |
Above-mentioned raw materials mixes in a blender, slowly adds the distilled water of 30 times of Rhizoma amorphophalli glucomannan quality and stirs, and to forming even gel, this gel is further taked to reduce pressure after the cold drying, smashs and sieve out the granule of 0.1～2mm to pieces with bruisher.Record 38700 of capsules, Simple Obesity crowd's test-meal, 6 of every days, 4 week back average weight declines 3.9%.
Embodiment 8:
| Rhizoma amorphophalli glucomannan | Molecular weight 2.0 * 10 5 | 10Kg |
| Oligo polyflavanol | Purity 90% | 1Kg |
| Chromium | Pyridine chromium | 0.2g |
| Copper | Copper sulfate | 1.5g |
| Ferrum | Ferrous sulfate | 15g |
| Zinc | Zinc sulfate | 20g |
| V C | 1Kg |
Above-mentioned raw materials mixes in a blender, slowly add Rhizoma amorphophalli glucomannan quality 3-30 doubly distilled water and stir, to forming even gel, this gel is further taked to reduce pressure after the cold drying, smashs and sieve out the granule of 0.1～2mm to pieces with bruisher.Record 20900 of capsules, Simple Obesity crowd's test-meal, 6 of every days, 4 week back average weight declines 6.4%.
Claims (10)
1, a kind of giantarum fat-reducing granule that contains oligo polyflavanol is characterized in that: be embedded with oligo polyflavanol and vitamin and mineral in the konjak portuguese gansu polyose gel granule.
2, the giantarum fat-reducing granule that contains oligo polyflavanol according to claim 1 is characterized in that: by mass ratio, oligo polyflavanol: vitamin: mineral: Rhizoma amorphophalli glucomannan is 1: 0.5～10: 1～20: 5～100.
3, the giantarum fat-reducing granule that contains oligo polyflavanol according to claim 1 and 2, it is characterized in that: the degree of polymerization scope of contained oligo polyflavanol is 2～6, system is by extracting the natural grease enzyme inhibitor that obtains in Folium Nelumbinis or Receptaculum Nelumbinis or Punica granatum L. or Folium Kaki or Semen Vitis viniferae or the Herba Cassiae Nomamis, its purity is 20～90%.
4, the giantarum fat-reducing granule that contains oligo polyflavanol according to claim 1 and 2, it is characterized in that: contained vitamin is V
A, V
C, V
EIn one or more.
5, a kind of giantarum fat-reducing granule that contains oligo polyflavanol according to claim 1 and 2, it is characterized in that: contained mineral is one or more in calcium, chromium, copper, zinc, ferrum, the magnesium.
6, a kind of giantarum fat-reducing granule that contains oligo polyflavanol according to claim 1 and 2, it is characterized in that: Rhizoma amorphophalli glucomannan is for having molecular weight ranges 5.0 * 10
4～5.0 * 10
5Micropowder.
7, the described preparation method that contains the giantarum fat-reducing granule of oligo polyflavanol of a kind of claim 1, it is characterized in that: above-mentioned raw materials is mixed in a blender by proportioning, the distilled water and the stirring that slowly add 3～30 times of Rhizoma amorphophalli glucomannan quality, to forming even gel, this gel is further taked to reduce pressure after the cold drying, smashs and sieve out the granule that particle diameter is 0.1～2mm to pieces with bruisher.
8, the described purposes that contains the giantarum fat-reducing granule of oligo polyflavanol of a kind of claim 1 is characterized in that: be used for diet food.
9, the purposes that contains the giantarum fat-reducing granule of oligo polyflavanol according to claim 8 is characterized in that: be pressed into chewable tablet or tablet or record into capsule or as the filling heart of cake.
10, the purposes that contains the giantarum fat-reducing granule of oligo polyflavanol according to claim 8 is characterized in that: mix being pressed into milk slice as the additive of beverage or with defatted milk powder etc.
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| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CNB2006101247914A CN100522211C (en) | 2006-10-18 | 2006-10-18 | A giantarum fat-reducing granule containing oligo polyflavanol and preparation method and use |
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|---|---|---|---|
| CNB2006101247914A CN100522211C (en) | 2006-10-18 | 2006-10-18 | A giantarum fat-reducing granule containing oligo polyflavanol and preparation method and use |
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| CN100522211C CN100522211C (en) | 2009-08-05 |
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Cited By (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN102217698A (en) * | 2011-07-29 | 2011-10-19 | 福建农林大学 | Environment-friendly chewing gum and preparation method thereof |
| CN102406696A (en) * | 2010-09-26 | 2012-04-11 | 北京北大维信生物科技有限公司 | New application of common aeschynomene herb and extract thereof |
| CN102640931A (en) * | 2012-05-08 | 2012-08-22 | 李全进 | Konjac health-protection consumptive-thirst capsule and preparation method thereof |
| WO2013166858A1 (en) * | 2012-05-08 | 2013-11-14 | 潍坊汇润食品有限公司 | Amorphophallus konjac healthcare and laxative capsule and preparation method therefor |
| CN108144063A (en) * | 2017-12-25 | 2018-06-12 | 北京康比特体育科技股份有限公司 | A kind of preparation method of pellet liquid-filling capsule with Weight-reducing health |
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2006
- 2006-10-18 CN CNB2006101247914A patent/CN100522211C/en not_active Expired - Fee Related
Cited By (11)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN102406696A (en) * | 2010-09-26 | 2012-04-11 | 北京北大维信生物科技有限公司 | New application of common aeschynomene herb and extract thereof |
| CN102217698A (en) * | 2011-07-29 | 2011-10-19 | 福建农林大学 | Environment-friendly chewing gum and preparation method thereof |
| CN102217698B (en) * | 2011-07-29 | 2012-08-29 | 福建农林大学 | Environment-friendly chewing gum and preparation method thereof |
| CN102640931A (en) * | 2012-05-08 | 2012-08-22 | 李全进 | Konjac health-protection consumptive-thirst capsule and preparation method thereof |
| CN102640931B (en) * | 2012-05-08 | 2013-10-09 | 潍坊汇润食品有限公司 | Konjac health-protection consumptive-thirst capsule and preparation method thereof |
| WO2013166858A1 (en) * | 2012-05-08 | 2013-11-14 | 潍坊汇润食品有限公司 | Amorphophallus konjac healthcare and laxative capsule and preparation method therefor |
| WO2013166859A1 (en) * | 2012-05-08 | 2013-11-14 | 潍坊汇润食品有限公司 | Amorphophallus konjac healthcare and consumptive thirst capsule and preparation method therefor |
| US20150064244A1 (en) * | 2012-05-08 | 2015-03-05 | Weifang Huirun Food Co., Ltd. | Konjac formulation and method for preparing the same |
| US9399024B2 (en) * | 2012-05-08 | 2016-07-26 | Shandong Hearun Dietary Hall Co., Ltd. | Konjac formulation and method for preparing the same |
| CN108144063A (en) * | 2017-12-25 | 2018-06-12 | 北京康比特体育科技股份有限公司 | A kind of preparation method of pellet liquid-filling capsule with Weight-reducing health |
| CN108144063B (en) * | 2017-12-25 | 2020-06-23 | 北京康比特体育科技股份有限公司 | Preparation method of pellet liquid-filled capsule with weight-losing and health-care functions |
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|---|---|
| CN100522211C (en) | 2009-08-05 |
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