CN1939403A - Production of compound Danshen root injection - Google Patents
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- CN1939403A CN1939403A CN 200510104996 CN200510104996A CN1939403A CN 1939403 A CN1939403 A CN 1939403A CN 200510104996 CN200510104996 CN 200510104996 CN 200510104996 A CN200510104996 A CN 200510104996A CN 1939403 A CN1939403 A CN 1939403A
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Abstract
A compound Danshen injection is prepared from red sage root, notoginseng, borneol, cosolvent and stabilizer. Its preparing process is also disclosed.
Description
Technical field
The present invention relates to a kind of compound Danshen root injection and preparation method thereof, specifically, relate to compound Danshen root injection that contains by Radix Salviae Miltiorrhizae, Radix Notoginseng, Borneolum Syntheticum and cosolvent and stabilizing agent and preparation method thereof.
Background technology
The compound preparation that compound red sage root preparation is made up of salviamiltiorrhizabung, Radix Notoginseng and Borneolum Syntheticum, Pharmacopoeia of People's Republic of China version in 2005 has been included FUFANG DANSHEN PIAN and FUFANG DANSHEN DIWAN.FUFANG DANSHEN PIAN and FUFANG DANSHEN DIWAN are arranged in the market, and clinical report shows that compound red sage root preparation has good effect aspect the treatment cardiovascular, and market sale is better always.In recent years, Pharma Inc. is also deep day by day to the research of compound red sage root preparation both at home and abroad, many new dosage forms on the basis of original tablet, have been developed, compound Salviae Miltiorrhizae oral cavity disintegration tablet and preparation technology are disclosed as CN200410017940.8, CN02111976.7 discloses FUFANG DANSHEN JIAONANG and preparation method, and CN200310120817 discloses patent documentations such as compound red sage root spray and preparation method; Also the someone discovers the purposes of the disease of compound red sage root preparation beyond the treatment cardiovascular, the application of the damage that this three kinds of drug regimens cause in the chronic ethanol picked-up of treatment is disclosed as CN03144259.5, CN200310122038.8 discloses the application of this drug regimen in the medicine of treatment aspirin resistance, patent CN200410046126.9 and patent CN200410071050.5 also disclose a kind of compound red sage root freezing-dried powder injection and preparation method thereof, a kind of preparation technology of freeze drying powder injection of compound red sange root of novelty is provided, and these researchs have been made important contribution to further exploitation compound red sage root preparation.
The present invention is the new technology that the further research done on existing drug preparation technique obtains.According to Pharmacopoeia of People's Republic of China version record in 2005, Borneolum Syntheticum is water white transparency or the crisp crystallization of translucent lamellar, and it is easily molten in ethanol, chloroform or ether, but almost insoluble in water.This physical property of Borneolum Syntheticum has caused so far also not having the injection type listing of compound Salviae Miltiorrhizae.In order effectively to address this problem, patent CN200410046126.9 and patent CN200410071050.5 find to utilize HP-enclose Borneolum Syntheticum can effectively solve the problems of dissolution of Borneolum Syntheticum, find that but scrutinize this patented method this patented method is earlier Borneolum Syntheticum to be prepared into the preparation lyophilized formulations that feeds intake again behind the clathrate with HP-.Discover that above two kinds of patented methods prepare the complex process of Borneolum Syntheticum hydroxypropyl-beta-cyclodextrin inclusion, inclusion rate is lower, and is consuming time and energy expenditure is bigger.By continuous test, I have found a kind of new simple method for preparing the compound Salviae Miltiorrhizae lyophilized formulations, that is: Borneolum Syntheticum is added an amount of ethanol and make it dissolving, the HP-that other gets recipe quantity is dissolved in an amount of water, alcoholic solution with Borneolum Syntheticum under the ultrasound condition slowly is added in the aqueous solution of HP-, after treating the solution clarification, continue ultrasonic 20min, get the aqueous solution of Borneolum Syntheticum, then with Borneolum Syntheticum aqueous solution and Radix Salviae Miltiorrhizae total phenolic acids Radix Notoginseng total arasaponins aqueous solution, lyophilization, promptly.This method is simple to operation, and has saved raw material and energy resource consumption greatly.
Because Borneolum Syntheticum is easily molten in ethanol, chloroform or ether, but almost insoluble in water, causes the dissolubility of FUFANG DANSHEN ZHUSHEYE and stability all not good, so also there is not the injection listing of compound Salviae Miltiorrhizae at present.Discover, utilize the cosolvent of HP-, in prescription, add dissolubility and the stability problem that preferred stabilizing agent just can effectively solve this injection again, obtain being fit to the FUFANG DANSHEN ZHUSHEYE of clinical use as Borneolum Syntheticum.
Summary of the invention:
The present invention is the improvement to FUFANG DANSHEN PIAN (being recorded in " Pharmacopoeia of People's Republic of China 2005 version one one ") and known compound Danshen root injection preparation technology, it is a kind of simple that purpose is to provide, dissolubility and high FUFANG DANSHEN ZHUSHEYE and the compound red sage root freezing-dried powder injection preparation method of stability.The present invention finds stable, the sophisticated preparation technology of a kind of the most suitable known commercial production at present and clinical needs by the preparation technology of preferred compound Danshen root injection.Discover, the preparation technology of compound Danshen root injection of the present invention is better than known technology, technology than before can effectively economize in raw materials and energy resource consumption, and utilizes the product stability of this prepared and dissolubility good, for clinical application provides a kind of preferred compound Salviae Miltiorrhizae novel formulation.
The concrete technology that the present invention prepares compound Danshen root injection is as follows:
One, the preparation technology of square Radix Salviae Miltiorrhizae Injection
Get 60 ℃ of dryings of red rooted salvia 8 hours, and be ground into coarse powder, take by weighing recipe quantity, add 12 times of water gagings, dipping spends the night, and decocts 1.5 hours, filter, medicinal residues add 12 times of water gagings and decocted 1.5 hours, get decoction liquor twice, be concentrated into every milliliter and contain medical material 1g, transfer pH to 6～7, add 5% gelatin solution of 0.4 times of medical material amount with the NaOH test solution, leave standstill, add ethanol and make and contain alcohol amount and reach 50%, the cold preservation standing over night, centrifugal, supernatant adds ethanol again to be made and contains alcohol amount and reach 80%, and the cold preservation standing over night filters, filtrate is concentrated into every milliliter for 60 ℃ and contains medical material 2g, concentrated solution adds hydrochloric acid and transfers pH to 2～3, and the ethyl acetate that adds 4 times of medical material amounts is divided four extractions, and extract adds the activated carbon of medical material amount 2%, refluxed 30 minutes, filter, filtrate concentrates drying for 60 ℃, get Radix Salviae Miltiorrhizae total phenolic acids, standby.Get 60 ℃ of dryings of pseudo-ginseng 8 hours, and be ground into coarse powder, take by weighing recipe quantity, add 10 times of 75% ethanol, dipping spends the night, with the flow velocity percolation of 1～3ml/minkg, the percolate concentrate drying becomes crude product, crude product adds 15 times of water gaging dissolvings, and macroporous adsorbent resin D-101 post on the solution is with the water washing post bed of 3 times of column volume amounts, 70% ethanol elution with 2 times of column volume amounts, eluent adds the neutral alumina with medical material equivalent, and reflux 15 minutes filters; Filtrate adds the active carbon of medical material amount 2%, refluxes 30 minutes, filter, and filtrate recycling ethanol, 80 ℃ of drying under reduced pressure get Radix Notoginseng total arasaponins, and are standby.Take by weighing the Borneolum Syntheticum of recipe quantity, add an amount of ethanol and make it dissolving, the HP-that other gets recipe quantity is dissolved in an amount of water, alcoholic solution with Borneolum Syntheticum under the ultrasound condition slowly is added in the aqueous solution of HP-, after treating the solution clarification, continue ultrasonic 20min, get the aqueous solution of Borneolum Syntheticum, standby.Getting Radix Salviae Miltiorrhizae total phenolic acids adds suitable quantity of water and makes it molten and loose in water, drip the NaOH test solution and make pH value of solution 6～7, add recipe quantity sodium sulfite, Radix Notoginseng total arasaponins, Borneolum Syntheticum aqueous solution, add water to 80% of full dose, transfer pH value of solution 6～7, add water to full dose, 0.22 μ m microporous filter membrane filters, packing, sealing, sterilized 30 minutes for 100 ℃, promptly.
When determining this preparation technology, we have done the consumption and the stabilizing agent of following experiment sieving hydroxypropyl beta cyclodextrin.
(1) screening of the consumption of hydroxypropyl beta cyclodextrin
The molecular weight of HP-is about 11.7 times of Borneolum Syntheticum, so we select following proportioning to investigate.
| HP-(g) | Borneolum Syntheticum (g) | |
| 1 | 12 | 1 |
| 2 | 12.5 | 1 |
| 3 | 13 | 1 |
| 4 | 13.5 | 1 |
Taking by weighing Borneolum Syntheticum 4g is dissolved in the 10ml ethanol, taking by weighing 4 parts of HP-in the ratio in the last table is dissolved in respectively in the 50ml water, the alcoholic solution 2.5ml of measuring Borneolum Syntheticum joins under ultrasound condition in above-mentioned four parts of HP-aqueous solutions, continue ultrasonic 20min, investigate the solution situation and measure the content of Borneolum Syntheticum in the aqueous solution.Result such as following table.
| Sample number into spectrum | The solution character | Content of bornyl alcohol (mg/ml) |
| 1 # | Solution is opalescence slightly | 81.75 |
| 2 # | Solution is clear and bright colourless | 98.55 |
| 3 # | Solution is clear and bright colourless | 99.02 |
| 4 # | Solution is clear and bright colourless | 98.35 |
Through screening, the dissolubility of Borneolum Syntheticum in water is better when HP-is higher than 12.5 times of Borneolum Syntheticum amount, so we are decided to be the consumption of HP-12.5 times of the Borneolum Syntheticum amount.
(2) screening of stabilizing agent
The index components of sample has reduction in various degree in sterilization process, and solution colour deepens, so we add antioxidant increase stability of sample in sample.We select sodium sulfite according to antioxidant commonly used, and cysteine hydrochloride screens.
Prepare sample solution according to the method in the sterilising temp screening, add 0.1%, 0.2% sodium sulfite, cysteine hydrochloride according to following table.
| Numbering | Sodium sulfite | Cysteine hydrochloride |
| 1 | - | - |
| 2 | 0.1％ | - |
| 3 | 0.2％ | - |
| 4 | - | 0.1％ |
| 5 | - | 0.2％ |
The solution packing, sealing, 100 ℃ of sterilization 30min.Result such as following table:
| Numbering | 1 | 2 | 3 | 4 | 5 |
| Character | Yellow clear liquid | Faint yellow clear liquid | Faint yellow clear liquid | Faint yellow clear liquid, cooling back adularescent precipitation | Faint yellow clear liquid, cooling back adularescent precipitation |
| PH value | 6.02 | 6.37 | 6.40 | 6.39 | 6.32 |
| Danshensu (mg/ bottle) | 4.52 | 4.37 | 4.42 | - | - |
| Protocatechualdehyde (mg/ bottle) | 0.30 | 0.27 | 0.29 | - | - |
| Salvianolic acid B | 12.43 | 13.73 | 13.90 | - | - |
| Arasaponin R1 (mg/ bottle) | 2.43 | 2.48 | 2.41 | - | - |
| Ginsenoside Rg1's (mg/ bottle) | 9.65 | 9.64 | 9.54 | - | - |
| Ginsenoside Rb1's (mg/ bottle) | 6.58 | 6.52 | 6.64 | - | - |
| Borneolum Syntheticum (mg/ bottle) | 12.06 | 11.98 | 11.99 | - | - |
Conclusion: sample sterilization back adularescent precipitation is separated out after adding cysteine hydrochloride; Sodium sulfite improves significantly to the color of the back solution of sterilizing, comprehensive above-mentioned test we are defined as 0.1% sodium sulfite with the antioxidant of this product as a result.
Two, the preparation technology of injection use compound Radix Salviae Miltiorrhizae freeze-dried powder
Get 60 ℃ of dryings of red rooted salvia 8 hours, and be ground into coarse powder, take by weighing recipe quantity, add 12 times of water gagings, dipping spends the night, and decocts 1.5 hours, filter, medicinal residues add 12 times of water gagings and decocted 1.5 hours, get decoction liquor twice, be concentrated into every milliliter and contain medical material 1g, transfer pH to 6～7, add 5% gelatin solution of 0.4 times of medical material amount with the NaOH test solution, leave standstill, add ethanol and make and contain alcohol amount and reach 50%, the cold preservation standing over night, centrifugal, supernatant adds ethanol again to be made and contains alcohol amount and reach 80%, and the cold preservation standing over night filters, filtrate is concentrated into every milliliter for 60 ℃ and contains medical material 2g, concentrated solution adds hydrochloric acid and transfers pH to 2～3, and the ethyl acetate that adds 4 times of medical material amounts is divided four extractions, and extract adds the activated carbon of medical material amount 2%, refluxed 30 minutes, filter, filtrate concentrates drying for 60 ℃, get Radix Salviae Miltiorrhizae total phenolic acids, standby.Get 60 ℃ of dryings of pseudo-ginseng 8 hours, and be ground into coarse powder, take by weighing recipe quantity, add 10 times of 75% ethanol, dipping spends the night, with the flow velocity percolation of 1～3ml/minkg, the percolate concentrate drying becomes crude product, crude product adds 15 times of water gaging dissolvings, and macroporous adsorbent resin D-101 post on the solution is with the water washing post bed of 3 times of column volume amounts, 70% ethanol elution with 2 times of column volume amounts, eluent adds the neutral alumina with medical material equivalent, and reflux 15 minutes filters; Filtrate adds the active carbon of medical material amount 2%, refluxes 30 minutes, filter, and filtrate recycling ethanol, 80 ℃ of drying under reduced pressure get Radix Notoginseng total arasaponins, and are standby.Take by weighing the Borneolum Syntheticum of recipe quantity, add an amount of ethanol and make it dissolving, the HP-that other gets recipe quantity is dissolved in an amount of water, alcoholic solution with Borneolum Syntheticum under the ultrasound condition slowly is added in the aqueous solution of HP-, after treating the solution clarification, continue ultrasonic 20min, get the aqueous solution of Borneolum Syntheticum, standby.Getting Radix Salviae Miltiorrhizae total phenolic acids adds suitable quantity of water and makes it molten and loose in water, drip the NaOH test solution and make pH value of solution 6～7, add 10% mannitol (W/V), Radix Notoginseng total arasaponins, Borneolum Syntheticum aqueous solution, add water to 80% of full dose, transfer pH value of solution 6～7, add water to full dose, 0.22 μ m microporous filter membrane filters, be packed as the 2ml/ bottle, lyophilizing, promptly.
Specific embodiment
Following examples are intended to further specify the present invention, scope of the present invention are not limited.
Example 1
Prescription (by 1000 bottles)
Radix Salviae Miltiorrhizae 1350g
Radix Notoginseng 423g
Borneolum Syntheticum 12g
HP-150g
Sodium sulfite 10g
Ethanol is an amount of
Water for injection adds to 2000ml
Make 1000 bottles
Take by weighing Radix Salviae Miltiorrhizae total phenolic acids, Radix Notoginseng total arasaponins, Borneolum Syntheticum, HP-, the sodium sulfite of recipe quantity according to the paste-forming rate of extract; Radix Salviae Miltiorrhizae total phenolic acids adds suitable quantity of water to be made it molten and looses in water, drips the NaOH test solution and makes pH value of solution 6～7, adds Radix Notoginseng total arasaponins, sodium sulfite makes it dissolving; Borneolum Syntheticum adds an amount of dissolve with ethanol, and HP-is dissolved in an amount of water, and the alcoholic solution with Borneolum Syntheticum under the ultrasound condition slowly is added in the aqueous solution of HP-, treat solution clarification after, continue ultrasonic 20min, the aqueous solution of Borneolum Syntheticum; With Borneolum Syntheticum aqueous solution and Radix Salviae Miltiorrhizae total phenolic acids Radix Notoginseng total arasaponins aqueous solution, add water to 80% of full dose, mixing is transferred pH value of solution 6～7, adds water to full dose, and 0.22 μ m microporous filter membrane filters, packing, sealing was sterilized 30 minutes for 100 ℃, promptly.
Example 2
Prescription (by 1000 bottles)
Radix Salviae Miltiorrhizae 1350g
Radix Notoginseng 423g
Borneolum Syntheticum 12g
HP-150g
Sodium sulfite 10g
Ethanol is an amount of
Water for injection adds to 2000ml
Make 1000 bottles
Get 60 ℃ of dryings of red rooted salvia 8 hours, and be ground into coarse powder, take by weighing recipe quantity, add 12 times of water gagings, dipping spends the night, and decocts 1.5 hours, filter, medicinal residues add 12 times of water gagings and decocted 1.5 hours, get decoction liquor twice, be concentrated into every milliliter and contain medical material 1g, transfer pH to 6～7, add 5% gelatin solution of 0.4 times of medical material amount with the NaOH test solution, leave standstill, add ethanol and make and contain alcohol amount and reach 50%, the cold preservation standing over night, centrifugal, supernatant adds ethanol again to be made and contains alcohol amount and reach 80%, and the cold preservation standing over night filters, filtrate is concentrated into every milliliter for 60 ℃ and contains medical material 2g, concentrated solution adds hydrochloric acid and transfers pH to 2～3, and the ethyl acetate that adds 4 times of medical material amounts is divided four extractions, and extract adds the activated carbon of medical material amount 2%, refluxed 30 minutes, filter, filtrate concentrates drying for 60 ℃, get Radix Salviae Miltiorrhizae total phenolic acids, standby.Get 60 ℃ of dryings of pseudo-ginseng 8 hours, and be ground into coarse powder, take by weighing recipe quantity, add 10 times of 75% ethanol, dipping spends the night, with the flow velocity percolation of 1～3ml/minkg, the percolate concentrate drying becomes crude product, crude product adds 15 times of water gaging dissolvings, and macroporous adsorbent resin D-101 post on the solution is with the water washing post bed of 3 times of column volume amounts, 70% ethanol elution with 2 times of column volume amounts, eluent adds the neutral alumina with medical material equivalent, and reflux 15 minutes filters; Filtrate adds the active carbon of medical material amount 2%, refluxes 30 minutes, filter, and filtrate recycling ethanol, 80 ℃ of drying under reduced pressure get Radix Notoginseng total arasaponins, and are standby.Take by weighing the Borneolum Syntheticum of recipe quantity, add an amount of ethanol and make it dissolving, the HP-that other gets recipe quantity is dissolved in an amount of water, alcoholic solution with Borneolum Syntheticum under the ultrasound condition slowly is added in the aqueous solution of HP-, after treating the solution clarification, continue ultrasonic 20min, get the aqueous solution of Borneolum Syntheticum, standby.Getting Radix Salviae Miltiorrhizae total phenolic acids adds suitable quantity of water and makes it molten and loose in water, drip the NaOH test solution and make pH value of solution 6～7, add 10% mannitol (W/V), Radix Notoginseng total arasaponins, Borneolum Syntheticum aqueous solution, add water to 80% of full dose, transfer pH value of solution 6～7, add water to full dose, 0.22 μ m microporous filter membrane filters, be packed as the 2ml/ bottle, lyophilizing, promptly.
Claims (6)
1, a kind of FUFANG DANSHEN ZHUSHEYE is characterized in that comprising Radix Salviae Miltiorrhizae, Radix Notoginseng, Borneolum Syntheticum and cosolvent and stabilizing agent.
2, FUFANG DANSHEN ZHUSHEYE as claimed in claim 1 is characterized in that cosolvent is selected from the mixed system of tween 20, HP-, tween 80, Polyethylene Glycol, polyoxyethylene castor oil, polyoxyethylene hydrogenated Oleum Ricini, polyvinylpyrrolidone, poloxamer, span, lecithin and their compositions.
3, FUFANG DANSHEN ZHUSHEYE as claimed in claim 1 is characterized in that stabilizing agent is selected from the mixed system of sodium sulfite, vitamin C and their compositions.
4, FUFANG DANSHEN ZHUSHEYE as claimed in claim 1 is characterized in that also containing in this injection adding adequate amount of ethanol.
5, FUFANG DANSHEN ZHUSHEYE as claimed in claim 1, its feature may further comprise the steps:
(1) gets 60 ℃ of dryings of red rooted salvia 8 hours, be ground into coarse powder, take by weighing recipe quantity, add 12 times of water gagings, dipping spends the night, and decocts 1.5 hours, filter, medicinal residues add 12 times of water gagings and decocted 1.5 hours, get decoction liquor twice, be concentrated into every milliliter and contain medical material 1g, transfer pH to 6～7, add 5% gelatin solution of 0.4 times of medical material amount with the NaOH test solution, leave standstill, add ethanol and make and contain alcohol amount and reach 50%, the cold preservation standing over night, centrifugal, supernatant adds ethanol again to be made and contains alcohol amount and reach 80%, and the cold preservation standing over night filters, filtrate is concentrated into every milliliter for 60 ℃ and contains medical material 2g, concentrated solution adds hydrochloric acid and transfers pH to 2～3, and the ethyl acetate that adds 4 times of medical material amounts is divided four extractions, and extract adds the activated carbon of medical material amount 2%, refluxed 30 minutes, filter, filtrate concentrates drying for 60 ℃, get Radix Salviae Miltiorrhizae total phenolic acids, standby.
(2) get 60 ℃ of dryings of pseudo-ginseng 8 hours, be ground into coarse powder, take by weighing recipe quantity, add 10 times of 75% ethanol, dipping spends the night, with the flow velocity percolation of 1～3ml/minkg, the percolate concentrate drying becomes crude product, crude product adds 15 times of water gaging dissolvings, and macroporous adsorbent resin D-101 post on the solution is with the water washing post bed of 3 times of column volume amounts, 70% ethanol elution with 2 times of column volume amounts, eluent adds the neutral alumina with medical material equivalent, and reflux 15 minutes filters; Filtrate adds the active carbon of medical material amount 2%, refluxes 30 minutes, filter, and filtrate recycling ethanol, 80 ℃ of drying under reduced pressure get Radix Notoginseng total arasaponins, and are standby.
(3) take by weighing the Borneolum Syntheticum of recipe quantity, add an amount of ethanol and make it dissolving, the HP-that other gets recipe quantity is dissolved in an amount of water, alcoholic solution with Borneolum Syntheticum under the ultrasound condition slowly is added in the aqueous solution of HP-, after treating the solution clarification, continue ultrasonic 20min, get the aqueous solution of Borneolum Syntheticum, standby.
(4) getting Radix Salviae Miltiorrhizae total phenolic acids adds suitable quantity of water and makes it molten and loose in water, drip the NaOH test solution and make pH value of solution 6～7, add recipe quantity sodium sulfite, Radix Notoginseng total arasaponins, Borneolum Syntheticum aqueous solution, add water to 80% of full dose, transfer pH value of solution 6～7, add water to full dose, 0.22 μ m microporous filter membrane filters, packing, sealing, sterilized 30 minutes for 100 ℃, promptly.
6, FUFANG DANSHEN ZHUSHEYE as claimed in claim 1 is characterized by it and can also be made as the injection freeze-dried products.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN 200510104996 CN1939403A (en) | 2005-09-26 | 2005-09-26 | Production of compound Danshen root injection |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN 200510104996 CN1939403A (en) | 2005-09-26 | 2005-09-26 | Production of compound Danshen root injection |
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|---|---|
| CN1939403A true CN1939403A (en) | 2007-04-04 |
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| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN 200510104996 Pending CN1939403A (en) | 2005-09-26 | 2005-09-26 | Production of compound Danshen root injection |
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Cited By (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN102100712A (en) * | 2011-02-17 | 2011-06-22 | 云南植物药业有限公司 | Method for extracting panax notoginseng saponins by using continuous countercurrent ultrasonic extraction combined film technology |
| CN103525639A (en) * | 2013-10-22 | 2014-01-22 | 北京普利耐特生物科技有限公司 | Pyrroloquinoline quinone-containing wine |
| CN104473883A (en) * | 2014-11-26 | 2015-04-01 | 中国人民解放军第四军医大学 | Acetyl tanshinol freeze-dried powder injection and preparation method thereof |
-
2005
- 2005-09-26 CN CN 200510104996 patent/CN1939403A/en active Pending
Cited By (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN102100712A (en) * | 2011-02-17 | 2011-06-22 | 云南植物药业有限公司 | Method for extracting panax notoginseng saponins by using continuous countercurrent ultrasonic extraction combined film technology |
| CN103525639A (en) * | 2013-10-22 | 2014-01-22 | 北京普利耐特生物科技有限公司 | Pyrroloquinoline quinone-containing wine |
| CN103525639B (en) * | 2013-10-22 | 2015-09-16 | 北京普利耐特生物科技有限公司 | A kind of wine containing Pyrroloquinoline quinone |
| CN104473883A (en) * | 2014-11-26 | 2015-04-01 | 中国人民解放军第四军医大学 | Acetyl tanshinol freeze-dried powder injection and preparation method thereof |
| CN104473883B (en) * | 2014-11-26 | 2017-06-13 | 中国人民解放军第四军医大学 | A kind of acetyl danshensu freeze drying powder injection and preparation method thereof |
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Open date: 20070404 |