CN1926119A - 作为趋化因子受体调节剂的磺酰胺取代的三嗪化合物 - Google Patents

作为趋化因子受体调节剂的磺酰胺取代的三嗪化合物 Download PDF

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Publication number
CN1926119A
CN1926119A CNA2005800064731A CN200580006473A CN1926119A CN 1926119 A CN1926119 A CN 1926119A CN A2005800064731 A CNA2005800064731 A CN A2005800064731A CN 200580006473 A CN200580006473 A CN 200580006473A CN 1926119 A CN1926119 A CN 1926119A
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China
Prior art keywords
phenyl
pharmaceutically acceptable
alkyl
solvate
formula
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Pending
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Chinese (zh)
Inventor
普伦杰·梅加尼
杰弗里·斯通豪斯
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AstraZeneca AB
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AstraZeneca AB
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Publication of CN1926119A publication Critical patent/CN1926119A/zh
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    • C07—ORGANIC CHEMISTRY
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    • C07D251/00—Heterocyclic compounds containing 1,3,5-triazine rings
    • C07D251/02—Heterocyclic compounds containing 1,3,5-triazine rings not condensed with other rings
    • C07D251/12—Heterocyclic compounds containing 1,3,5-triazine rings not condensed with other rings having three double bonds between ring members or between ring members and non-ring members
    • C07D251/26—Heterocyclic compounds containing 1,3,5-triazine rings not condensed with other rings having three double bonds between ring members or between ring members and non-ring members with only hetero atoms directly attached to ring carbon atoms
    • C07D251/40—Nitrogen atoms
    • C07D251/48—Two nitrogen atoms
    • C07D251/52—Two nitrogen atoms with an oxygen or sulfur atom attached to the third ring carbon atom
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D251/00—Heterocyclic compounds containing 1,3,5-triazine rings
    • C07D251/02—Heterocyclic compounds containing 1,3,5-triazine rings not condensed with other rings
    • C07D251/12—Heterocyclic compounds containing 1,3,5-triazine rings not condensed with other rings having three double bonds between ring members or between ring members and non-ring members
    • C07D251/14—Heterocyclic compounds containing 1,3,5-triazine rings not condensed with other rings having three double bonds between ring members or between ring members and non-ring members with hydrogen or carbon atoms directly attached to at least one ring carbon atom
    • C07D251/16—Heterocyclic compounds containing 1,3,5-triazine rings not condensed with other rings having three double bonds between ring members or between ring members and non-ring members with hydrogen or carbon atoms directly attached to at least one ring carbon atom to only one ring carbon atom
    • C07D251/18—Heterocyclic compounds containing 1,3,5-triazine rings not condensed with other rings having three double bonds between ring members or between ring members and non-ring members with hydrogen or carbon atoms directly attached to at least one ring carbon atom to only one ring carbon atom with nitrogen atoms directly attached to the two other ring carbon atoms, e.g. guanamines

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  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
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  • Physical Education & Sports Medicine (AREA)
  • Dermatology (AREA)
  • Diabetes (AREA)
  • Neurosurgery (AREA)
  • Biomedical Technology (AREA)
  • Pulmonology (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Oncology (AREA)
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  • Pain & Pain Management (AREA)
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CNA2005800064731A 2004-01-21 2005-01-19 作为趋化因子受体调节剂的磺酰胺取代的三嗪化合物 Pending CN1926119A (zh)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
GB0401269.6 2004-01-21
GBGB0401269.6A GB0401269D0 (en) 2004-01-21 2004-01-21 Compounds

Publications (1)

Publication Number Publication Date
CN1926119A true CN1926119A (zh) 2007-03-07

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ID=31971197

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CNA2005800064731A Pending CN1926119A (zh) 2004-01-21 2005-01-19 作为趋化因子受体调节剂的磺酰胺取代的三嗪化合物

Country Status (6)

Country Link
US (1) US20090192134A1 (enExample)
EP (1) EP1713783A2 (enExample)
JP (1) JP2007518781A (enExample)
CN (1) CN1926119A (enExample)
GB (1) GB0401269D0 (enExample)
WO (1) WO2005070903A2 (enExample)

Cited By (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN102887867A (zh) * 2011-07-21 2013-01-23 中国科学院上海药物研究所 一类三嗪类化合物、该化合物的制备方法及其用途
CN107001374A (zh) * 2014-12-01 2017-08-01 阿斯利康(瑞典)有限公司 作为髓过氧化物酶抑制剂的1‑[2‑(氨基甲基)苄基]‑2‑硫代‑1,2,3,5‑四氢‑4h‑吡咯并[3,2‑d]嘧啶‑4‑酮
CN107033093A (zh) * 2017-06-07 2017-08-11 浙江工业大学 N‑取代磺酰胺类化合物及其制备方法与应用

Families Citing this family (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
NZ584471A (en) 2007-10-11 2012-01-12 Glaxosmithkline Llc Triazine cyclohexane carboxamide compounds and their use
CN102159555A (zh) * 2008-07-16 2011-08-17 阿斯利康(瑞典)有限公司 嘧啶基氨磺酰衍生物及其治疗趋化因子介导的疾病的用途
KR20250086780A (ko) 2022-10-19 2025-06-13 아스트라제네카 아베 Cx3cr1 조절제로서의 2,4,6-삼중치환된 1,3,5-트리아진
WO2025219939A1 (en) 2024-04-17 2025-10-23 Astrazeneca Ab Salts and polymorphs of cx3cr1 modulators
WO2025219950A1 (en) 2024-04-18 2025-10-23 Astrazeneca Ab Small molecule cx3cr1 modulators
WO2025219947A1 (en) 2024-04-18 2025-10-23 Astrazeneca Ab Thio-substituted 1,3,5-triazine cx3cr1 modulators

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPH03231974A (ja) * 1990-02-07 1991-10-15 Canon Inc 記録液
GB2359078A (en) * 2000-02-11 2001-08-15 Astrazeneca Uk Ltd Pharmaceutically active pyrimidine derivatives
TWI328007B (en) * 2002-01-16 2010-08-01 Astrazeneca Ab Novel compounds
KR101255356B1 (ko) * 2002-06-12 2013-04-17 케모센트릭스, 인크. 염증 및 면역 질병의 치료를 위한 ｃｃｒ１ 길항물질로서사용하기 위한 1-아릴-4-치환된 피페라진 유도체
GB0217431D0 (en) * 2002-07-27 2002-09-04 Astrazeneca Ab Novel compounds

Cited By (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN102887867A (zh) * 2011-07-21 2013-01-23 中国科学院上海药物研究所 一类三嗪类化合物、该化合物的制备方法及其用途
CN102887867B (zh) * 2011-07-21 2015-04-15 中国科学院上海药物研究所 一类三嗪类化合物、该化合物的制备方法及其用途
CN107001374A (zh) * 2014-12-01 2017-08-01 阿斯利康(瑞典)有限公司 作为髓过氧化物酶抑制剂的1‑[2‑(氨基甲基)苄基]‑2‑硫代‑1,2,3,5‑四氢‑4h‑吡咯并[3,2‑d]嘧啶‑4‑酮
CN107001374B (zh) * 2014-12-01 2019-06-14 阿斯利康(瑞典)有限公司 作为髓过氧化物酶抑制剂的1-[2-(氨基甲基)苄基]-2-硫代-1,2,3,5-四氢-4h-吡咯并[3,2-d]嘧啶-4-酮
CN107033093A (zh) * 2017-06-07 2017-08-11 浙江工业大学 N‑取代磺酰胺类化合物及其制备方法与应用
CN107033093B (zh) * 2017-06-07 2019-09-03 浙江工业大学 N-取代磺酰胺类化合物及其制备方法与应用

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WO2005070903A2 (en) 2005-08-04
JP2007518781A (ja) 2007-07-12
GB0401269D0 (en) 2004-02-25
EP1713783A2 (en) 2006-10-25
WO2005070903A3 (en) 2005-10-27
US20090192134A1 (en) 2009-07-30

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