CN1915019A - Composition of bactericide - Google Patents

Composition of bactericide Download PDF

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Publication number
CN1915019A
CN1915019A CN 200510060416 CN200510060416A CN1915019A CN 1915019 A CN1915019 A CN 1915019A CN 200510060416 CN200510060416 CN 200510060416 CN 200510060416 A CN200510060416 A CN 200510060416A CN 1915019 A CN1915019 A CN 1915019A
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China
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compound
cucumber
group
composition
methyl
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CN100401889C (en
Inventor
陈定花
胡伟群
朱卫刚
许天明
郑志文
陈杰
黄松其
孔小林
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Zhejiang Chemical Industry Research Institute Co Ltd
Sinochem Lantian Co Ltd
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ZHEJIANG CHEM-TECH GROUP Co Ltd
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Abstract

A composite bactericide for preventing and eliminating the diseases and pests of plant contains a methyl methoxy arylate type compound A and a compound B containing at least one systemic, protective and/or edaphic bactericide.

Description

Microbicide compositions
The present invention relates to microbicide compositions, refer more particularly to the composition and use thereof that contains methoxy-methyl acrylate compounds ZJ0712 and some interior absorption, contact and soil fungicides.
People know that the bactericide that is used for agricultural and gardening has many variety classeses.But the plant disease kind of preventing and kill off is also many, preventing and kill off in the agricultural production application of reality to various plant diseases, select comparatively ideal sterilization very difficult often, particularly the tillage method of current some crop changes, generally adopt greenhouse gardening as vegetables, melon, flowers etc., the condition of high temperature, high humidity very easily makes the generation of various diseases and popular, causes serious economy loss.As powdery mildew, downy mildew and anthracnose is the The main pathogenic fungi of damage to crops, and some leading products in the past such as triazole type and acid amide fungicides be because the generation of resistance, and consumption strengthens at double, is badly in need of new varieties and substitutes.Therefore, the novel germicide composition of should seek to have high activity, fungicidal spectrum is wide is considered in the new damage by disease and insect aspect that causes for the variation that is adapted to agriculture form.
The present invention solves the problem of above-mentioned proposition, a kind of microbicide compositions that present inventors invented, (the exploitation code name: ZJ0712), the plant disease that this compound causes sac fungi, mastigomycetes and imperfect fungus etc. has excellent control efficiency to it is characterized in that containing in the composition a kind of methoxy-methyl acrylate compounds ZJ0712.Preparation example shown in this compound general formula is existing narration in Chinese invention patent (application number 03120882.7).The structure and the title of compound are as follows:
(E) 2-[2-(2,5-dimethyl phenoxy methyl)-phenyl]-3-methoxy-methyl acrylate (ZJ0712)
The object of the present invention is to provide a kind of composition that methoxy-methyl acrylate compounds and known other bactericide are mixed that contains of foregoing invention, its objective is to further improving bactericidal effect, expanding prevention object and delaying service life of compound (I).
At the methoxy-methyl acrylate compounds shown in the general formula (I) (to call compound (I) in the following text) with select more than one bactericide (to call compound (II) in the following text) among suction in some, protection and/or the soil bactericide for use.
Now find after deliberation, with compound (I) and some systemic fungicide, protective fungicide and soil fungicides be mixed use after, their bactericidal activity has tangible raising.
Microbicide compositions of the present invention is characterized in that containing in the composition and has at least a kind of (interior absorption, protectiveness and/or soil) bactericide to make up in a kind of compound (I) and the compound (II).These bactericide all can be bought on market, they can write by the Ministry of Chemical Industry's agricultural chemicals central information facility " external pesticide species handbook or by the Britain crop protection committee (The British Crop Protection Coucil) publish " agricultural chemicals handbook (The Pesticide Manual) is found in the 11st edition (1997).
Be specially adapted to composition of the present invention, by (interior absorption, protectiveness and the soil) bactericide in the compound (II) example as follows:
A. systemic fungicide
1.S-benzyl-O, O-systox (kitazine)
2.S-benzyl-O, O-diisopropyl thiophosphate (iprobenfos)
(3.N-3, the 5-dichlorophenyl)-1,2-dimethylcyclopropane-1,2-diamides (procymidone)
4.4,4 '-(adjacent phenyl) two (3-sulfo-allophanic acid dimethyl ester) (thiophanate-methyl)
5. benzimidazolyl-2 radicals-Ji amido methyl formate (carbendazim)
6. (E)-(RS)-1-(2,4 dichloro benzene base)-4,4-diformazan base-(1H-1,2,4-triazol-1-yl) penta-1-alkene-3-alcohol (alkene azoles alcohol)
(7.2-4-chlorphenyl)-2-(1H-1,2,4-triazol-1-yl methyl) own nitrile (nitrile bacterium azoles)
(8.1-4-chlorophenoxy)-3,3-dimethyl-1-(1H-1,2,4-triazole-1-yl) butanone (triazolone)
9. (RS)-1-(4-chlorphenyl)-4, the 4-diformazan is based on-(1H-1,2,4-triazol-1-yl methyl) penta-3-alcohol (Tebuconazole)
10. (±)-1[2-(2,4 dichloro benzene base)-4-propyl group plinth, 3-dioxolanes-2-ylmethyl]-1H-1,2,4-triazole (propiconazole)
11. (RS)-2-(2,4 dichloro benzene base)-1-(1H-1,2,4-triazol-1-yl)-oneself-2-alcohol (own azoles alcohol)
Two 12. (4-fluorophenyl) methyl (1H-, 2,4-triazol-1-yl methylene) silane (Flusilazole)
13. (5RS, 6RS)-6-hydroxyl-2,2,7,7-tetramethyl (1,2, the 4-triazol-1-yl) octanone-3 (hot oxazolone).
14.1-n-butyl amine base formyl-methyl 2-benzimidazolecarbamate (benomyl)
(15.N-2-methoxyl group acetyl group)-N-(2, the 6-xylyl)-D, L-methyl lactamine (metalaxyl)
16. phosphoric acid hydrogen ethyl ester (aliette)
(17.4-[3-4-chlorphenyl)-3-(3, the 4-Dimethoxyphenyl) acryloyl group] morpholine (dimethomorph)
(18.1-2-cyano group-2-methoxyimino acetyl group)-3-ethyl carbamide (white urea cyanogen)
19.N-phenylacetyl group-N-2,6-3,5-dimethylphenyl-DL-methyl lactamine (M 9834)
20.2-methoxyl group-N-(2-oxo-1,3-oxazolidine-3-yl) acetyl-2 ', 6 '-spirit of dimethylaniline (Evil frost)
(21. ±)-a-[N-(3-chlorophenyl) cyclopropane formamido group]-r-butyrolactone (cyprofuram)
(22. ±)-a-2-chloro-N-2,6-xylyl acetylaminohydroxyphenylarsonic acid r-butyrolactone (fenfuram)
(23.3-dimethylamino) propyl carbamic acid propyl ester (Propamocarb)
24. (RS)-and 4-chloro-N-[cyano group (ethyoxyl) methyl] benzamide (zarilamid)
(25. ±)-α-2-chloro-N-2,6-xylyl acetamido-r-butyrolactone (fenfuram)
(26.N-2-furanylcarbonyl)-N-(2,6-3,5-dimethylphenyl racemic amino methyl propionate) (furalaxyl)
27. phosphorous acid or phosphorous acid disodium
B. protective fungicide
1.O-2 6-two chloro-are right-tolyl O, and O-dimethyl disulfide substituted phosphate (tolelofos-methyl)
2.3-chloro-N-(3-chloro-5-trifluoromethyl-2-pyridine radicals)-α, α, α-three fluoro-2,6-dinitro-right-toluidines (fluazinam)
3.N-propyl group-N-[2-(2,4, the 6-Trichlorophenoxy) ethyl] imidazoles-1-formamide (prochloraz)
4. tetrachloro-1,3-benzene dicarbonitrile (daconil M) (tpn)
5.1,2,3,6-tetrahydrochysene N-(trichloro-methylthio) phthalimide (captan)
6.4 6-two chloro-N-(2-chlorophenyl)-1,3,5-three chant in a loud voice-2-amine (anilazine)
7. copper oxychloride (Cupravit)
8. two (dimethyl dithiocarbamic acid) zinc (ziram)
9.N-isoxazole-5-base carbonyl-N-(2, the 6-xylyl)-racemization-methyl lactamine (pressing down mould prestige)
10.O-2-deoxidation methylamino-α-L-glucopyranosyl-(1 → 2)-O-5 deoxidation-3-C-formoxyl-α-L-lysol furyl glycosyl-(1 → 4)-N 3, N 3-diaminourea streptamine (streptomycin)
11. the polycomponent coordination compound of ethylene bisdithiocarbamic manganese and zinc salt (mancozeb)
12. tetramethyl thiuram disulfide (tmtd, thiram)
13.1,2,3,6-tetrahydrochysene-N-(1,1,2,2-tetrachloro ethylmercapto group) BIDA (difoltan)
14. sulphur Sulfur (Sulfur, Sulfur)
15. ethylidene dithiocarbamate manganese (maneb)
C. soil fungicides
1.O-2 6-two chloro-are right-tolyl O, and O-dimethyl disulfide substituted phosphate (tolelofos-methyl)
2. pcnb (pcnb)
3.N-isoxazole-5-base carbonyl-N-(2, the 6-xylyl)-racemization-methyl lactamine (pressing down mould prestige)
4.N-trichloro-methylthio-N-dimethylamino sulfonanilide (enemy bacterium prestige)
(5.3-dimethylamino) propyl carbamic acid propyl ester (Propamocarb)
6.2-methoxyl group-N-(2-oxo-1,3-oxazolidine-3-yl) acetyl-2 ', 6 '-spirit of dimethylaniline (Evil frost)
7.S-ethyl (3-dimethyl amido propyl group) sulfo-amido formate (prothiocarb).
8. (5RS, 6RS)-6-hydroxyl-2,2,7,7-tetramethyl (1,2, the 4-triazol-1-yl) octanone-3 (hot oxazolone)
Composition of the present invention, to preferable in above listed compound (II) the A group bactericide be methyl sulfur bacterium, carbendazim, alkene azoles alcohol, nitrile bacterium azoles, Tebuconazole, propiconazole, own azoles alcohol, Flusilazole, aliette, dimethomorph, metalaxyl, white urea cyanogen, the white spirit of M 9834, Evil, Propamocarb, phosphorous acid or phosphorous acid disodium; Preferable in above listedization thing (II) the B group bactericide is fluazinam, prochloraz, tpn, mancozeb and Sulfur; Preferable in above listed compound (II) the C group bactericide is hot oxazolone and Propamocarb.
Compound (I) also can make up with three components or many components with the compound of (A group, B group and C group) in the compound (II).
The plant disease that may prevent and kill off according to microbicide compositions of the present invention, adducible as rice blast (Pyriculariaoryzae), Helminthosporium of brown spot of rice (Helminthosporium oryzae), cereal class powdery mildew (Erysiphe graminis), wheat scab (Fusarium graminearum), wheat class leaf rust (P.Striiformis; P.recondita; P.hordei and P.graminis), wheat leaf rot (Septoria tritici), citrus black spot (Phoma citricarpa), citrus scab (Sphaceloma fawcetti), anthracnose of orange (Colletrichum gloeosporioides), apple blossom rot (Sclerotiniamali), apple mildew (Podosphaera leucotricha), alternaria leaf spot of apple (Alternaria mali), pear scab (Venturia pirina), pears powdery mildew (Phyllactinia pyri), rust of pear (Gymnosporangium haraenum), anthracnose of peach (Gloeosporium laeticolor), Ramulus Juglandis rot (Melanconium juglandinum), peach gummosis (Dothiorella gregaria), nuclear anthracnose (Gloeosporium laeticolor) downy mildew of garpe (PlasmoparaViticola), anthracnose of grape (Sphaceloma ampelinumn), bitter rot or anthracnose of grape (Glomerella cingulata), grape powdery mildew (Uncinula necator), grape room rot (Physalospora baccae), anthracnose of kaki (Gloeosporiumkaki), cucumber downy mildew (Pseudoperonospora cubensis), melon anthracnose (Colletotrichum lagenarium), powdery mildew of cucumber (Sphaerotheca fuliginea), the climing rot of cucumber (Mycosphaerella melonis), gray mold of cucumber (Botrytis cinerea), early blight of tomato (Alternaria solani), cladosporium leaf and fruit mould of tomato (Cladosporium fulvum) and late blight (Phytophthora infestans), alternaria leaf spot of crucifers (Alternaria brassicae), rape Leucoplakia (Ceroosporella brassicae), anthracnose of flax (Cilletotrichum boehmieriae), the cercospora leaf spot of groundnut (Mycosphaerella personatum), brown spot (Cercospora arachidicola), potato late blight (Phytophthora infestans), powdery mildew of strawberry (Sphaerotheca humuli), tobacco powdery mildew (Erysiphecichoraoearum), anthracnose (Colletotrichum nicotianae), cercospora leaf spot of sugar beet (Cercospora beticola), rose scab (Diplocarpon rosae), powdery mildew (Sphaerotheca pannosa), cassava brown spot (Cercosporavicosae), cassava anthracnose (Colletotrichum gloeosporioides), peronophythora litchi (Peronophthora litchic), sigatoka (Cercospora musae), banana anthracnose (Gloeosporium musarum), papaya papaw anthracnose (Colletotrichum gloeosporioides; Colletotrichum capsici) ， Mango fruit anthracnose plant diseases such as (Colletotrichumgloeosporioides).
Composition of the present invention has protection, treatment and eradicant action concurrently to plant disease, for example can be used for various crop: plants such as cucumber, pumpkin, cucurbit, wheat, barley, strawberry, grape, tobacco, lupulus, peanut, potato, tomato, Chinese cabbage, capsicum, lettuce, wild cabbage, onion, citrus, banana, kind art Gua, Mango fruit, lichee and flowers.Controls such as the plurality of plant diseases that caused by sac fungi, mastigomycetes and imperfect fungus such as powdery mildew, downy mildew, anthracnose are had special efficacy, and efficacy of a drug effect rapidly, reduce advantages such as resistance and broad spectrum of activity.
In microbicide compositions of the present invention, the mixing of compound (I) and compound (II) is not particularly limited, but the amount that contains active component depends on the amount of application when compound uses separately, depends on that also a kind of compound is relevant to the degree and the target fungi of the synergistic effect of target fungi with the ratio of another kind of compound.Wherein, compound (1) can mix with in the compound (II) any one, and relative scale is 1: 1～100 to 20: 1 based on the umber of active component weight, but preferable ratio is 1: 20 to 10: 1.Compound (I) also can with compound (II) in any two kinds mix, relative scale is 1: 1～20: 1～100 to 50: 1～20: 1 based on the umber of active component weight, but preferable ratio is 1: 1～10: 3～50 to 10: 1～10: 1.
Composition of the present invention can also comprise carrier, carrier can be solid or liquid, comprise being generally gas but compression back be the material of liquid, carrier can be solid or liquid, can use any usually in preparing desinsection, bactericidal composition used any carrier all can use.Be easy to use after active component and carrier are mixed with, for example can in plant, seed or soil, use, be easy to store, transport or loading and unloading.
Microbicide compositions of the present invention just mixes use with compound (I) and compound (II).But usually compound (I) and compound (II) are mixed, and and solid carrier, liquid-carrier and/or gas shape carrier mix, and add preparation used additives such as surfactant, adhesive, dispersant, stabilizing agent as required, be prepared into aqueous dispersion pulvis, suspending agent, granule, dry colloidal suspending agent, missible oil, aqua, finish, fumigant, aerosol, microcapsule formulations etc. and use, perhaps compound (I) and compound (II) carry out preparationizations respectively as described above, according to circumstances after the dilute with water, separately preparation product is mixed and use.Active component in the microbicide compositions of the present invention is 0.5～95% of a gross weight.
These preparations can be prepared by method in common.For example active substance is mixed with liquid flux and/or solid carrier, add surfactant, emulsifier, dispersant, stabilizing agent, wetting agent simultaneously, can also add adhesive, dyestuff or odorant.Therefore, the present invention also comprises the method for preparing above-mentioned microbicide compositions.
Comprise natural and synthetic clay, silicate as suitable solid carrier, for example natural silica and diatomite; Magnesium silicate, for example talcum; Magnesiumaluminumsilicate, for example active face soil and vermiculite; Alumina silicate is kaolinite, montmorillonite, mica for example; Calcium carbonate, calcium sulphate, ammonium sulfate; Synthetic hydrated silica and and synthetic calcium silicates or alumina silicate; The solid carrier that is particularly suitable for pulvis comprises the rock dust of natural formation, for example attapulgite, bentonite, montmorillonite, diatomite; Synthetic mineral matter, for example microdispersed silicic acid or the aluminium oxide of grinding; Suitable particulate vector comprises the natural rock of broken classification, for example calcite, marble, float stone, sepiolite, dolomite and by synthetic particle organic and that inorganic powder is made.In addition, particle can prepare from organic material, for example wood chip, peanut shell, maize cob fiber and dry tobacco rods.
Suitable liquid-carrier comprises water: water can be used as solvent or thinner, and organic solvent also can be used as secondary solvent or antifreeze additive, and appropriate organic solvent comprises aromatic hydrocarbons, for example toluene, dimethylphenyl phenyl, benzene Fluhyzon and chlorinated aromatic hydrocarbons; Chloro aliphatic hydrocarbon, for example chlorobenzene, vinyl chloride, trichloroethanes, carrene, chloroform, carbon tetrachloride and many chloroethanes; Aliphatic hydrocarbon, for example petroleum distillate, cyclohexane, light mineral oil and paraffin; Yet, particularly suitable be polar solvent, i.e. alcohols, for example isopropyl alcohol, butanols, ethylene glycol, phenmethylol, furfuryl alcohol, cyclohexanol, ether and ester; Ketone such as acetone, MEK, methyl ethyl ketone, methyl iso-butyl ketone (MIBK), cyclohexanone and butyrolactone, dimethyl formamide, dimethyl sulfoxide (DMSO) and N-Methyl pyrrolidone.Mixtures of different liquids often is suitable for.
Surfactant can be emulsifier, dispersant or wetting agent, and it can be ionic surface active agent or non-ionic surface active agent.As: the sodium salt of polyacrylic acid and lignin sulfonic acid or calcium salt; The fatty acid or fatty amine or the acid amides that contain at least 12 carbon atoms in the molecule; The condensation product of oxirane and/or expoxy propane; Glycol, sorbierite, sucrose or pentaerythritol fatty ester and these esters and oxirane and or the ring oxirane condensation product; Glycerine, sorbierite, sucrose or pentaerythritol fatty ester; The sulphate of these condensation products or sulfonate; In molecule, contain the sulfuric acid of at least 10 carbon atoms or the alkali metal or the alkali salt of sulphonic acid ester, sodium salt preferably, the sodium salt of lauryl sodium sulfate, Teepol, sulfonated castor oil for example, and alkylaryl sodium sulfonate, for example ten sodium alkyl benzene sulfonates: and the copolymer of polymers of ethylene oxide, oxirane and expoxy propane.Particularly following material can be used emulsifier and/or wetting agent; Nonionic emulsifier is as polyoxyethylene fatty acid ester, polyoxyethylene aliphatic alcohol ether, polyoxyethylene fatty amine, ethoxylated castor oil and anion emulsifier etc.
As adhesive or dispersant, for example casein, gelatin, polysaccharose (starch, arabia gum, fiber derivative etc.), lignin derivative, bentonite, carbohydrate, synthesizing water-solubility macromolecule etc., as stabilizing agent, as acid phosphatase isopropyl ester vegetable oil, mineral oil, fatty acid etc.
According to type, in solid pharmaceutical preparation, contain 5～85% active substance by weight usually, preferable is 20～80%; In pharmaceutical solutions, contain 10～50% active substance by weight, in suspension preparation, 10～60% active substance by weight.
Composition of the present invention can be mixed with: wetting powder, soluble powder, pulvis, (aqueous dispersion) granule, missible oil, suspending agent, aqueous suspension, microemulsion, aqueous emulsion, dust agent, sustained release agent, aerosol or aerosol etc.Wetting powder contains 10～85% active component usually, except solid inert carrier, contains 3～10% dispersant usually, contains 0～10% stabilizing agent and/or other additives if desired, for example bleeding agent or sticker.Pulvis is made into the powder concentrate usually, and it and wetting powder have similar composition, but does not contain dispersant, and this pulvis with other solid carrier dilution, is contained the composition of 0.5～10%W active substance in the field usually.Granule is made 10～100 international standard sieves (1.676～1.152mm) particles usually, can be by reuniting or soaking into the method preparation, usually granule contains 0.5～75% active component and the additive of 0～10%W, for example stabilizing agent, surfactant, slow release regulator and adhesive.So-called dry flowable pulvis is made up of smaller containing than the particle of higher concentration active component.Missible oil except containing solvent, containing and help the cosolvent when needed, also contains 10～50%W/V active component, other additives of 2～20%W/V emulsifier and 0～20W%/V, for example stabilizing agent, bleeding agent and corrosion inhibitor usually.Suspending concentrate need stir usually, to obtain stable non-deposition flowable product, it contains the active component of 10～75%W usually, 0.5 the dispersant of～15%W, 0.1 the suspending agent of～10%W for example protects other additives of colloid and thixotropic agent, 0～10%W, for example defoamer, corrosion inhibitor, stabilizing agent, bleeding agent and sticker, with water or organic liquid, wherein active component is undissolved basically; Some organic solid or mineral salt can be dissolved in the preparation, to help to prevent deposition or as the antifreezing agent of water.
Moisture dispersion liquid and emulsion, for example the composition that obtains of dilute with water aqueous suspension agent of the present invention or water dispersion granule concentrate also within the scope of the invention.Above-mentioned emulsion can be Water-In-Oil or oil-in-water type, can have dense thick pulpous state denseness.
The product that the present invention describes can be the product dosage form, and promptly each material mixes in the composition.Yet the composition of composition also can provide preparation separately, directly mixes in bucket (jar) before using.Concentrate of the present invention mixes the concentration that obtains required active substance usually with water.
Composition of the present invention also can contain other component, for example has weed killer herbicide, insecticide, nematocide, protective agent growth regulator, nutrient for plants or soil conditioner etc. and mixes.
Composition of the present invention is to the longer duration of the protection activity of the plant disease that caused by sac fungi, mastigomycetes and imperfect fungus.And be absorbed conduction in plant, and slowly discharge the carrier of Fungicidal compounds, the preparation of this slow release can be transported in the climing rattan and near the soil the root of plant; Or comprise a kind of adhesion component, so that can be applied directly on the cauline leaf of trailing plant, therefore, to obtaining more effective control by fungus-caused plant disease.
Composition of the present invention can be used by common method, as cast, injection, spraying, dusting, scatter or be fuming.Microbicide compositions usage amount of the present invention is according to kind, mixing ratio, meteorological condition, preparation form, use age, method, place, controlling object and the crop etc. of active ingredient compound and different.Before crop is susceptible or susceptible initial stage medication, this point is very important usually for time of application.Because people are not recognized insect pest or crop smothering so intuitively immediately to susceptible elephant of crop initial stage in production application.Therefore, grasping the in good time control time is unusual crux.About composition relevant with selected single compound, also relevant usually to the length of crop pest guard time with many extraneous factors.
The present invention is according to embodiment, specify with following example: wherein containing its chemical name of methoxy-methyl acrylate compounds (I) is: (E) 2-[2-(2,5-dimethyl phenoxy methyl)-phenyl]-the 3-methoxy-methyl acrylate is an example, but example is not limited to the present invention.
The preparation of embodiment 1 54.55% (weight) wetting powder
Carbendazim 45.5%
Compound (I) 9.1%
NNO 4％
Draw back powder 1.5%
Attapulgite is supplemented to 100%
Each component (being solid) mixes, and pulverizes in cracker, reaches standard value up to grain fineness.
The preparation of embodiment 2 30% (weight) missible oil
Propiconazole 27.3%
Compound (I) 2.7%
DMF 20％
Emulsifier ZH0101 10%
Dimethylbenzene is supplemented to 100%
By the prescription requirement, it is even to add solvent, former medicine, emulsifier respectively, and heating for dissolving promptly obtains transparence missible oil in case of necessity.
The preparation of embodiment 3 25% (weight) aqueous suspension agent
Propiconazole 22.7%
Compound (I) 2.3%
WPJ 4％
JFC 1％
Ethylene glycol 3%
Xanthans 0.1%
Deionized water is supplemented to 100%
By the prescription requirement, be medium with water, former medicine, dispersant, suspending agent and antifreezing agent etc. are joined batching mix in the still, after ball mill or clipper were just pulverized, porphyrize in the sand milling still was made suspending agent.
The preparation of embodiment 4 50.2% (weight) wetting powder
Propiconazole 45.6%
Compound (I) 4.6%
M-9 5％
Morwet EMW 1％
Diatomite is supplemented to 100%
Compound method is with embodiment 1
The preparation of embodiment 5 15% (weight) missible oil
Fluazinam 13.6%
Compound (I) 1.4%
DMF 20％
Emulsifier ZH0101 10%
Dimethylbenzene is supplemented to 100%
Compound method is with embodiment 2
The preparation of embodiment 6 20% (weight) aqueous suspension agent
Fluazinam 18.2%
Compound (I) 1.8%
WPS 3％
Sopa-270 1％
Xanthans 0.15%
Urea dish 3%
Defoamer 0.2%
Deionized water is supplemented to 100%
Compound method is with embodiment 3
The preparation of embodiment 7 60% (weight) wetting powder
Fluazinam 58.5%
Compound (I) 1.5%
Supragil wp 2％
Supragil MNS190 3％
Kaolin is supplemented to 100%
Compound method is with embodiment 1
The preparation of embodiment 8 15% (weight) missible oil
Nitrile bacterium azoles 13.6%
Compound (I) 1.4%
DMF 5％
Emulsifier ZHO203 10%
TEBU/45 is supplemented to 100%%
Compound method is with embodiment 2
The preparation of embodiment 9 25% (weight) aqueous suspension agent
Own azoles alcohol 22.7%
Compound (I) 2.3%
Soprophor FL 3％
Igepal cc66o 2％
Propane diols 4%
Xanthans 0.2%
Deionized water is supplemented to 100%
Compound method is with embodiment 3
The preparation of embodiment 10 50.2% (weight) water dispersion granule
Own azoles alcohol 45.6%
Compound (I) 4.6%
Morwet D-425 7％
Morwet EFW 2％
Kaolin is supplemented to 100%
Water dispersion granule processing is by the requirement of filling a prescription, and former medicine, dispersion moisture agent, disintegrant, filler etc. mixed through comminution by gas stream become wetting powder, adds suitable quantity of water then and carries out granulation and obtain water dispersion granule.
The preparation of embodiment 11 20% (weight) fumicants
Eyeball bacterium azoles 18.2%
Compound (I) 1.8%
Calcium stearate 3%
Potassium nitrate 25%
Charcoal powder is supplemented to 100%
Compound method is with embodiment 3
The preparation of embodiment 12 40.% (weight) missible oil
Prochloraz 39.%
Compound (I) 1%
DMF 20％
Emulsifier 10%
Dimethylbenzene is supplemented to 100%
Compound method is with embodiment 2
The preparation of embodiment 13 40% (weight) aqueous suspension agent
Prochloraz 39%
Compound (I) 1%
WPJ 3％
NNO 2％
Glycerine 3%
Defoamer 0.2%
PVP 1％
Deionized water is supplemented to 100%
Compound method is with embodiment 3
The preparation of embodiment 14 15% (weight) missible oil
Tebuconazole 13.6%
Compound (I) 1.4%
DMF 5％
Emulsifier ZHO203 10%
TEBU/45 is supplemented to 100%%
Compound method is with embodiment 2
The preparation of embodiment 15 10% (weight) aqueous suspension agent
Tebuconazole 9.1%
Compound (I) 0.9%
M-9 1.5％
NNO 2.5％
Sopa-270 2％
Glycerine 3%
Xanthans 0.3%
Deionized water is supplemented to 100%
Compound method is with embodiment 3
The preparation of embodiment 16 60% (weight) water dispersion granule
Tebuconazole 54.5%
Compound (I) 5.5%
Many bacterium 9%
Morwet D-425 5％
Morwet EFW 2％
Sodium bentonite is supplemented to 100%
Compound method is with embodiment 10
The preparation of embodiment 17 65% (weight) wetting powder
Tebuconazole 59.1%
Compound (I) 5.9%
Sodium sulphate 8%
Sodium lignin sulfonate 5%
Lauryl sodium sulfate 5%
Kaolin is supplemented to 100%
Compound method is with embodiment 1
The preparation of embodiment 18 50% (weight) water dispersion granule
Tebuconazole 35.4%
Compound (I) 4.6%
Carbendazim 10%
Morwet D-425 4％
Morwet EFW 3％
Kaolin is supplemented to 100%
Compound method is with embodiment 10
The preparation of embodiment 19 5% (weight) dust agent
Tebuconazole 4.5%
Compound (I) 0.5%
Potter's clay is supplemented to 100%
Compound method is with embodiment 1
The preparation of embodiment 20 5% (weight) dust agent
Fluazinam 4.9%
Compound (I) 1%
Kaolin is supplemented to 100%
Compound method is with embodiment 1
The preparation of embodiment 21 20% (weight) fumicants
Tebuconazole 18.2%
Compound (I) 1.8%
Lead sulfate tribasic 5%
Ammonium nitrate 30%
Charcoal powder is supplemented to 100%
Compound method is with embodiment 1
The preparation of embodiment 22 52.5% (weight) wetting powder
Tpn 45.5%
Compound (I) 4.6%
Lauryl sodium sulfate 5%
Diatomite 10%
Sodium lignin sulfonate 5%
Chalk is supplemented to 100%
Compound method is with embodiment 1
The preparation of embodiment 23 25.76% (weight) aqueous suspension agent
Phosphorous acid 24.24%
Compound (I) 1.52%
Morwet D-425 3％
JFC 1.5％
Xanthans 0.2%
Ethylene glycol 3%
Defoamer 0.2%
Deionized water is supplemented to 100%
Compound method is with embodiment 3
The preparation of embodiment 24 70% (weight) wetting powder
Aliette 66.67%
Compound (I) 3.33%
AGO-300 2％
Draw back powder 1%
Kaolin is charged to 100%
Compound method is with embodiment 1
The preparation of embodiment 25 50% (weight) water dispersion granule
Aliette 47.62%
Compound (I) 2.38%
AGS-400 3％
Morwet EFW 1％
Kaolin is supplemented to 100%
Compound method is with embodiment 10
The preparation of embodiment 26 10% (weight) aqueous suspension agent
Ethylphosphorus lead 9.52%
Compound (I) 0.48%
WPJ 3％
NP-10 1％
Xanthans 0.2%
Propane diols 4%
Deionized water is supplemented to 100%
Compound method is with embodiment 3
Embodiment 27 61.47% (weight) wettable is divided the agent preparation
Metalaxyl 58.54%
Compound (I) 2.93%
NNO 3％
M-13 2％
Draw back powder 1.5%
Diatomite is supplemented to 100%
Compound method is with embodiment 1
The preparation of embodiment 28 25% (weight) aqueous suspension agent
Metalaxyl 23.8%
Compound (I) 19%
WPJ 3％
Morwet EFW 1％
Ethylene glycol 4%
Xanthans 0.15%
Defoamer 0.2%
Deionized water is supplemented to 100%
Compound method is with embodiment 3
The preparation of embodiment 29 50% (weight) water dispersion granule
Metalaxyl 47.62%
Compound (I) 2.38%
Morwet D-425 4％
Morwet EFW 2％
Ammonium sulfate 10%
Kaolin is supplemented to 100%
Compound method is with embodiment 10
The preparation of embodiment 30 20% (weight) fumicants
Carbendazim 19%
Compound (I) 1%
Potassium chlorate 10%
Ammonium nitrate 15%
Charcoal powder is supplemented to 100%
Compound method is with embodiment 1
The preparation of embodiment 31 10% (weight) aqueous suspension agent
Dimethomorph 8%
Compound (I) 2%
1601 4％
Sopa-270 2％
Bentonite 1%
Draw back powder 1%
Glycerine 3%
Deionized water is supplemented to 100%
Compound method is with embodiment 3
The preparation of embodiment 32 25% (weight) wetting powder
Dimethomorph 20%
Compound (I) 5%
Sodium lignin sulfonate 4%
Neopelex 1%
Sodium bentonite is supplemented to 100%
Compound method is with embodiment 1
The preparation of embodiment 33 15.7% (weight) missible oil
M 9834 14.3%
Compound (I) 1.4%
DMF 30％
Emulsifier ZH0207 12%
Toluene is supplemented to 100%
Compound method is with embodiment 2
The preparation of embodiment 34 10% (weight) aqueous suspension agent
M 9834 9.52%
Compound (I) 4.8%
WPJ 3％
JFC 1％
Bentonite 1%
Propane diols 5%
Defoamer 0.2%
Deionized water is supplemented to 100%
Compound method is with embodiment 3
The preparation of embodiment 35 60% (weight) water dispersion granule
Propamocarb 57.14%
Compound (I) 5.72%
Morwet D-425 5％
Morwet EFW 2％
Ammonium sulfate 10%
Kaolin is supplemented to 100%
Compound method is with embodiment 10
The preparation of embodiment 36 10% (weight) aqueous suspension agent
Propamocarb 9.52%
Compound (I) 0.48%
WPS-6 3％
Draw back powder 1%
White carbon 0.5%
Aluminium-magnesium silicate 2%
Ethylene glycol 4%
Deionized water is supplemented to 100%
Compound method is with embodiment 3
The preparation of embodiment 37 60% (weight) water dispersion granule
Propamocarb 50%
Compound (I) 1%
Aliette 9%
Morwet D-425 5％
Morwet EFW 3％
Urea element 5%
Kaolin is supplemented to 100%
Compound method is with embodiment 10
The preparation of embodiment 38 5% (weight) dust agent
Metalaxyl 4.76%
Compound (I) 0.24%
Bentonite is supplemented to 100%
Compound method is with embodiment 1
The preparation of embodiment 39 50% (weight) water dispersion granule
Propamocarb 40%
Compound (I) 2%
Aliette 8%
Morwet D-425 4％
Morwet EFW 3％
Ammonium sulfate 10%
Attapulgite is supplemented to 100%
Compound method is with embodiment 10
The preparation of embodiment 40 10% (weight) aqueous suspension agent
Propamocarb 8%
Compound (I) 0.5%
Aliette 1.5%
WPJ 3％
1601 1％
Xanthans 0.3%
Ethylene glycol 4%
Deionized water is supplemented to 100%
Compound method is with embodiment 3
The preparation of embodiment 41 5% (weight) dust agent
Propamocarb 4.76%
Compound (I) 0.24%
Diatomite is supplemented to 100%
Compound method is with embodiment 1
The preparation of embodiment 42 55% (weight) wetting powder
Propamocarb 52.38%
Compound (I) 2.62%
Diisooctyl sodium sulfosuccinate 2%
Lauryl sodium sulfate 8%
Sodium lignin sulfonate 8%
Kaolin is supplemented to 100%
Compound method is with example 1
The preparation of embodiment 43 20% (weight) fumicants
Propamocarb 19%
Compound (I) 1%
Calcium stearate 3%
Potassium nitrate 25%
Charcoal powder is supplemented to 100%
Compound method is with embodiment 1
The preparation of embodiment 44 50% (weight) wetting powder
Mancozeb 47.62%
Compound (I) 2.38%
Sodium lignin sulfonate 3%
K12 2％
Draw back powder 0.5%
Bentonite is supplemented to 100%
Compound method is with embodiment 1
The preparation of embodiment 45 20% (weight) fumicants
Mancozeb 19%
Compound (I) 1%
Ammonium chlorate 30%
Charcoal powder is supplemented to 100%
Compound method is with embodiment 1
The preparation of embodiment 46 50% (weight) water dispersion granule
Aliette 40%
Compound (I) 2%
Dimethomorph 8%
Morwet D-425 4％
Morwet EFW 3％
Ammonium sulfate 15%
Kaolin is supplemented to 100%
Compound method is with embodiment 10
The preparation of embodiment 47 52.5% (weight) wetting powder
Mancozeb 50%
Compound (I) 2.5%
Lauryl sodium sulfate 5%
Diatomite 10%
Sodium lignin sulfonate 5%
Chalk is supplemented to 100%
Compound method is with embodiment 1
The preparation of embodiment 48 10% (weight) aqueous suspension agent
Frost urea cyanogen 9.52%
Compound (I) 0.48%
Lauryl sodium sulfate 2%
Ethylene glycol 4%
Deionized water is supplemented to 100%
Compound method is with embodiment 3
2 kinds of active ingredient compounds that the present invention will provide, are tried to achieve by the Colby formula (1) of following mathematical expression 1 preventive effect that plant disease is desired at the indoor biological activity determination that carries out through mixing:
[computing formula 1]
E = X + Y - X × Y 100
X: with the active ingredient compd A, the actual preventive effect (%) when handling with m ppm
Y: with the active ingredient compd B, the actual preventive effect (%) when handling with m ppm
E: with the active ingredient compd A, with m ppm, with B, theoretical preventive effect (%) (to call theoretical preventive effect in the following text) when handling with n ppm.
In the ordinary course of things, with the compound of 2 kinds of active ingredients after mixed processing to preventing and treating the resulting actual preventive effect of crop pest (%), when bigger, we can say the compound of 2 kinds of active ingredients used with to have synergistic effect than theoretical preventive effect (%).Obtain actual preventive effect (%) with following computing formula 2.
[computing formula 2]
Figure A20051006041600191
In the greenhouse, some microbicide compositions has been carried out potted plant biological activity determination test to preventing and treating powdery mildew of cucumber and cucumber downy mildew, the bactericidal activity that reaches between composition and the single agent between the composition has been compared test.Represent that with drug effect test examples 49～68 microbicide compositions of the present invention has excellent preventive effect to plant disease below.
Embodiment 49 powderys mildew of cucumber protection activity test
In the greenhouse preparation of embodiment 8 and 10% compound (I) aqueous suspension agent being carried out biologically active to powdery mildew of cucumber relatively tests.
Cucumber variety: precious poplar No. 5
Controlling object: powdery mildew of cucumber (triazolone resistant strain)
Test method: the sandy loam of packing in plastic basin, the sowing cucumber seed is cultured to two leaves during one heart stage with cucumber seedling in the greenhouse, place to carry out the processing of medicament foliar spray on the crop sprayer 24 hours inoculation powdery mildew of cucumber spores behind the protectiveness test spray medicine.The middle in the controlled environment chamber cultivation of postvaccinal examination material was investigated in about 10 days.
Active substance Concentration (ppm) Preventive effect (%)
Compound (I) 0.5 49.0
Nitrile bacterium azoles 5 37.8
Mixture 0.5+5 92.5
Result of the test shows: compound (I) 0.5ppm add nitrile bacterium azoles 5ppm to the preventive effect of powdery mildew of cucumber 92.5%, apparently higher than the preventive effect of two single agent.
Embodiment 50 powderys mildew of cucumber protection activity test
In the greenhouse preparation of embodiment 9 and 10% compound (I) aqueous suspension agent being carried out biologically active to powdery mildew of cucumber relatively tests.
Cucumber variety: precious poplar No. 5
Controlling object: powdery mildew of cucumber (triazolone resistant strain)
Test method is identical with embodiment 49
Active substance Concentration (ppm) Preventive effect (%)
Compound (I) 0.5 49.0
Own azoles alcohol 5 35.5
Mixture 0.5+5 90.0
Result of the test shows: compound (I) 0.5ppm add own azoles alcohol 5ppm to the preventive effect of powdery mildew of cucumber 90.0%, apparently higher than the preventive effect of two single agent.
Embodiment 51 powderys mildew of cucumber protection activity test
In the greenhouse preparation of embodiment 3 and 10% compound (I) aqueous suspension agent being carried out biologically active to powdery mildew of cucumber relatively tests.
Cucumber variety: precious poplar No. 5
Controlling object: powdery mildew of cucumber (triazolone resistant strain)
Test method is identical with embodiment 49
Active substance Concentration (ppm) Preventive effect (%)
Compound (I) 0.5 48.7
Propiconazole 5 38.2
Mixture 0.5+5 91.8
Result of the test shows: compound (I) 0.5ppm add propiconazole 5ppm to the preventive effect of powdery mildew of cucumber 91.8%, apparently higher than the preventive effect of two single agent.
Embodiment 52 powderys mildew of cucumber protection activity test
In the greenhouse preparation of embodiment 5 and 10% compound (I) aqueous suspension agent being carried out biologically active to powdery mildew of cucumber relatively tests.
Cucumber variety: precious poplar No. 5
Controlling object: powdery mildew of cucumber (triazolone resistant strain)
Test method is identical with embodiment 49
Active substance Concentration (ppm) Preventive effect (%)
Compound (I) 0.5 51.0
Fluazinam 20 34.8
Mixture 0.5+5 90.7
Result of the test shows: compound (I) 0.5ppm add fluazinam 20ppm to the preventive effect of powdery mildew of cucumber 90.7%, apparently higher than the preventive effect of two single agent.
Embodiment 53 powderys mildew of cucumber protection activity test
In the greenhouse preparation of embodiment 12 and 10% compound (I) aqueous suspension agent being carried out biologically active to powdery mildew of cucumber relatively tests.
Cucumber variety: precious poplar No. 5
Controlling object: powdery mildew of cucumber (triazolone resistant strain)
Test method is identical with embodiment 49
Active substance Concentration (ppm) Preventive effect (%)
Compound (I) 0.5 51.0
Prochloraz 20 35.3
Mixture 0.5+5 91.0
Result of the test shows: compound (I) 0.5ppm add Prochloraz 20ppm to the preventive effect of powdery mildew of cucumber 91.0%, apparently higher than the preventive effect of two single agent.
Embodiment 54 powderys mildew of cucumber protection activity test
In the greenhouse, with compound (I), Tebuconazole and 3 single agent of carbendazim separately and after 3 single agent put into ladle mixing evenly together by ratio, the preventive effect of cucumber powdery mildew of cucumber (triazolone resistant strain) is compared test.
Test method is identical with embodiment 49
Active substance Concentration (ppm) Preventive effect (%)
Compound (I) 0.5 48.7
Tebuconazole 5 31.0
Carbendazim 20 0
Mixture 0.5+5+20 100
Result of the test shows: compound (I) 0.5ppm adds Tebuconazole 5ppm and adds carbendazim 20ppm bucket again and mix, to the preventive effect of powdery mildew of cucumber 100%, apparently higher than the preventive effect of 3 single agent.
Embodiment 55 powderys mildew of cucumber protection activity test
In the greenhouse with compound (I), Tebuconazole and 3 medicaments of thiophanate-methyl separately and 3 medicaments to put into ladle mixing together by ratio even, to the efficiency test of cucumber powdery mildew of cucumber (triazolone resistant strain).
Test method is identical with test example 1
Active substance Concentration (ppm) Preventive effect (%)
Compound (I) 0.5 48.7
Tebuconazole 5 31.0
Thiophanate-methyl 20 0
Mixture 0.5+5+20 100
Result of the test shows: compound (I) 0.5ppm adds Tebuconazole 5ppm and adds carbendazim 20ppm bucket again and mix, to the preventive effect of powdery mildew of cucumber 100%, apparently higher than the preventive effect of 3 single agent.
Embodiment 56 powdery mildew of cucumber protectiveness activity tests
In the greenhouse each composition being carried out potted plant biological activity determination tests.To the activity between the composition, and between composition and the single agent to the comparative test of powdery mildew of cucumber bactericidal activity.The result shows: each composition is compared with single agent, all has obvious synergistic effect to preventing and treating powdery mildew of cucumber.It below is the prescription screening study of bactericidal composition.
Trial crops: cucumber (precious poplar No. 5)
Controlling object: powdery mildew of cucumber (triazolone resistant strain)
Test method: adopt the potted plant determination method of cucumber seedling, the sandy loam of in plastic basin, packing into, broadcast into cucumber seeds, it is stand-by during one heart stage to treat that cucumber seedling grows to two leaves, to test cucumber seedling places and carries out foliar spray on the crop sprayer and handle inoculation powdery mildew of cucumber spore after the crop after the processing was dried in the shade 24 hours naturally.The incidence of disease (%) was investigated in the middle in the controlled environment chamber cultivation of postvaccinal examination material in about 10 days, and obtained actual preventive effect (%) with formula 2.
Test compound Active ingredient concentration (ppm) Actual preventive effect (%) Theoretical preventive effect (%)
Compound (I)+Tebuconazole 0.5+5 93.2 66.9
Compound (I)+own azoles alcohol 0.5+5 90.5 68.9
Compound (I)+alkene azoles alcohol 0.5+5 91.9 67.8
Compound (I)+carbendazim 0.5+40 88.6 69.3
Compound (I)+Sulfur 0.5+50 85.3 71.4
Compound (I)+propiconazole 0.5+5 91.5 70.4
Compound (I)+Prochloraz 0.5+20 87.2 68.8
Compound (I)+fluazinam 0.5+20 85.5 67.9
Compound (I)+nitrile bacterium azoles 0.5+5 92.7 70.5
Compound (I)+triazolone 0.5+50 75.9 56.2
Compound (I)+thiophanate-methyl 0.5+40 86.9 67.9
Compound (I) 0.5 51.3
Tebuconazole 5 32.7
Own azoles alcohol 5 36.2
Alkene azoles alcohol 5 33.8
Carbendazim 40 37.0
Sulfur 50 41.3
Propiconazole 5 39.2
Prochloraz 20 35.9
Fluazinam 20 34.0
Nitrile bacterium azoles 5 39.5
Triazolone 50 10.1
Thiophanate-methyl 40 34.0
57 pairs of powdery mildew of cucumber protections of embodiment and therapeutic activity test
In the greenhouse, compound (I) is mixed by the ratio bucket with Tebuconazole, the row concentration of setting up departments then promptly 40,20 and 10ppm uses 25% Tebuconazole missible oil (concentration of treatment is identical with mixture) and 10% compound (I) aqueous suspension agent to compare test (test method is identical with embodiment 49) to preventing and treating yellow powdery mildew simultaneously.The result shows that compound (I) and Tebuconazole mix use, have obvious synergistic effect to preventing and treating yellow powdery mildew.
Reagent agent Experimental concentration (ppm) Control efficiency (%)
Prevention Treatment
Compound (I) 0.5 50.8 35.7
Tebuconazole 40 96.1 83.5
20 85.3 71.2
10 68.0 49.1
5 33.0 0
Composition 40 100 100
20 100 97.2
10 97.4 89.2
5 90.7 67.9
Embodiment 58 prevents and treats powdery mildew of cucumber simulation field control effectiveness test
In the greenhouse compound (I) is mixed by the ratio bucket with Tebuconazole, the concentration of treatment of mixture is 40,20 to use 25% Tebuconazole missible oil concentration of treatment identical with mixture simultaneously with 10ppm, simulates field control effectiveness test to preventing and treating yellow powdery mildew.
Trial crops: cucumber (precious poplar No. 5)
Controlling object: powdery mildew of cucumber (triazolone resistant strain)
Potted plant cucumber seedling is cultured to the 3-4 leaf phase, gives free rein to and fall ill,, will test cucumber seedling and place and carry out foliar spray on the crop sprayer and handle the test composition row concentration of setting up departments to the initial stage.Examination material after the processing places and cultivates 10 days " Invest, Then Investigate " preventive effects under the natural conditions.The result shows: compound (I) mixes with Tebuconazole, uses said composition when falling ill to the initial stage under field conditions (factors) to powdery mildew of cucumber, and its preventive effect is more than 89% under 20～40ppm concentration.
Reagent agent Experimental concentration (ppm) Control efficiency (%)
Tebuconazole 40 77.5
20 60.5
10 23.0
Composition 40 98.4
20 89.7
10 71.5
Embodiment 59 cucumber downy mildews protection activity test
In the greenhouse preparation of embodiment 24 and 10% compound (I) aqueous suspension agent being carried out biologically active to cucumber downy mildew relatively tests.
Cucumber variety: precious poplar No. 5
Controlling object: cucumber downy mildew (metalaxyl resistant strain)
Test method: the sandy loam of in plastic basin, packing into, sowing cucumber seed (precious poplar No. 5), in the greenhouse, cucumber seedling is cultured to two leaves during one heart stage, carrying out the medicament foliar spray at the crop sprayer handles, inoculation cucumber downy mildew spore after 24 hours, postvaccinal examination material place phytotron to cultivate 7 days investigation incidences of disease.
Active substance Concentration (ppm) Preventive effect (%)
Compound (I) 5 52.6
Aliette 100 5.0
Mixture 5+100 85.4
Result of the test shows: compound (I) 5ppm add aliette 100ppm to the preventive effect of cucumber downy mildew 85.4%, apparently higher than the preventive effect of two single agent.
Embodiment 60 cucumber downy mildews protection activity test
In the greenhouse with embodiment 22 preparation and 10% compound (I) aqueous suspension agent cucumber downy mildew carried out biologically active relatively test.
Cucumber variety: precious poplar No. 5
Controlling object: cucumber downy mildew (metalaxyl resistant strain)
Test method is identical with embodiment 59
Active substance Concentration (ppm) Preventive effect (%)
Compound (I) 5 52.6
Tpn 100 21.0
Mixture 5+100 88.0
Result of the test shows: it is 88.0% to the preventive effect of cucumber downy mildew that compound (I) 5ppm adds tpn 100ppm, apparently higher than the preventive effect of two single agent.
Embodiment 61 cucumber downy mildews protection activity test
In the greenhouse preparation of embodiment 32 and 10% compound (I) aqueous suspension agent being carried out biologically active to cucumber downy mildew relatively tests.
Cucumber variety: precious poplar No. 5
Controlling object: cucumber downy mildew (metalaxyl resistant strain)
Test method is identical with embodiment 59
Active substance Concentration (ppm) Preventive effect (%)
Compound (I) 5 53.0
Frost urea cyanogen 100 39.2
Mixture 5+100 92.7
Result of the test shows: it is 92.7%% to the preventive effect of cucumber downy mildew that compound (I) 5ppm adds white urea cyanogen 100ppm, apparently higher than the preventive effect of two single agent.
Embodiment 62 cucumber downy mildews protection activity test
In the greenhouse embodiment 33 preparations and 10% compound (I) aqueous suspension agent being carried out biologically active to cucumber downy mildew relatively tests.
Cucumber variety: precious poplar No. 5
Controlling object: cucumber downy mildew (metalaxyl resistant strain)
Test method is identical with embodiment 59
Active substance Concentration (ppm) Preventive effect (%)
Compound (I) 5 53.0
M 9834 100 30.1
Mixture 5+100 91.3
Result of the test shows: it is 91.3% to the preventive effect of cucumber downy mildew that compound (I) 5ppm adds M 9834 100ppm, apparently higher than the preventive effect of two single agent.
Embodiment 63 cucumber downy mildews protection activity test
In the greenhouse embodiment 6 preparations and 10% compound (I) aqueous suspension agent being carried out biologically active to cucumber downy mildew relatively tests.
Cucumber variety: precious poplar No. 5
Controlling object: cucumber downy mildew (metalaxyl resistant strain)
Test method is identical with embodiment 59
Active substance Concentration (ppm) Preventive effect (%)
Compound (I) 5 52.0
Fluazinam 100 25.9
Mixture 5+100 85.6
Result of the test shows: it is 85.6% to the preventive effect of cucumber downy mildew that compound (I) 5ppm adds fluazinam 100ppm, apparently higher than the preventive effect of two single agent.
Embodiment 64 cucumber downy mildews protection activity test
In the greenhouse with compound (I), Propamocarb and 3 medicaments of aliette separately and 3 single agent to put into ladle mixing together by ratio even, the preventive effect of cucumber downy mildew (metalaxyl resistant strain) is compared test.
Test method is identical with embodiment 59
Active substance Concentration (ppm) Preventive effect (%)
Compound (I) 5 50.8
Propamocarb 50 0
Aliette 100 6.0
Mixture 5+50+100 100
Result of the test shows: compound (I) 5ppm adds Propamocarb 50ppm and adds aliette 100ppm bucket again and mix, and is 100% to the preventive effect of cucumber downy mildew, apparently higher than the preventive effect of 3 single agent.
Embodiment 65 cucumber downy mildews protection activity test
Examination in the greenhouse with compound (I), Propamocarb and dimethomorph separately and 3 single agent to put into ladle mixing together by ratio even, the preventive effect of cucumber downy mildew (metalaxyl resistant strain) is compared test.
Test method is identical with embodiment 59
Active substance Concentration (ppm) Preventive effect (%)
Compound (I) 5 50.8
Dimethomorph 5 23.6
Propamocarb 50 0
Mixture 5+5+50 100
Result of the test shows: compound (I) 5ppm adds dimethomorph 5ppm and adds Propamocarb 50ppm bucket again and mix, and is 100% to the preventive effect of cucumber downy mildew, apparently higher than the preventive effect of 3 single agent.
Embodiment 66 cucumber downy mildew protectiveness activity tests
In the greenhouse each composition being carried out potted plant biological activity determination tests.To the activity between the composition, and between composition and the single agent to the comparative test of cucumber downy mildew bactericidal activity.The result shows: each composition is compared with single agent, and the control cucumber downy mildew is had synergistic effect.Below be the prescription screening study of bactericidal composition to cucumber downy mildew.
Trial crops: cucumber (precious poplar No. 5)
Controlling object: cucumber downy mildew (metalaxyl resistant strain)
Test method: adopt the cucumber seedling pot-culture method, the sandy loam of in plastic basin, packing into, broadcast into cucumber seeds, it is stand-by during one heart stage to treat that in hot-house culture cucumber seedling grows to two leaves, to test yellow seedling places and carries out foliar spray on the crop sprayer and handle inoculation cucumber downy mildew spore after the crop after the processing was dried in the shade 24 hours naturally.The middle in the controlled environment chamber value of preventing and kill off (%) of cultivating 7 days " Invest, Then Investigate " incidences of disease (%) and obtaining reality with formula 2 of postvaccinal examination material.
Test compound Active ingredient concentration (ppm) Actual value of preventing and kill off (%) Expectation value of preventing and kill off (%)
Compound (I)+Propamocarb 5+100 96.3 65.4
Compound (I)+white urea cyanogen 5+100 93.1 72.9
Compound (I)+aliette 5+100 89.4 56.6
Compound (I)+carbendazim 5+100 87.0 63.5
Compound (I)+tpn 5+100 85.6 65.5
Compound (I)+phosphorous acid 5+400 75.9 67.2
Compound (I)+metalaxyl 5+100 87.9 62.7
Compound (I)+fluazinam 5+100 89.3 62.6
Compound (I)+M 9834 5+100 94.9 57.5
Compound (I)+dimethomorph 5+10 92.8 74.7
Compound (I)+mancozeb 5+50 91.5 69.8
Compound (I) 5 53.4
Propamocarb 100 25.8
Frost urea cyanogen 100 41.0
Aliette 100 6.8
Carbendazim 100 21.7
Fluazinam 100 26.0
M 9834 100 29.7
Phosphorous acid 400 20.0
Tpn 100 19.8
Metalaxyl 100 8.7
Dimethomorph 10 45.8
Mancozeb 50 35.3
Embodiment 67 cucumber downy mildews protection activity test
In the greenhouse, compound (I) and Propamocarb are prepared separately earlier, then bucket being put in 2 single agent in proportion mixes, with the mixture row concentration of setting up departments, and with 2 single agent of Propamocarb of 10% compound (I) aqueous suspension agent and 72.2% cucumber downy mildew is carried out biologically active and relatively test.
Test method is identical with embodiment 59
Reagent agent Experimental concentration Preventive effect (%)
Compound (I) 5 53.0
Propamocarb 400 83.5
200 58.6
100 23.5
Composition 400 100
200 100
100 98.4
The result shows that compound (I) and Propamocarb mix use, obviously are better than the preventive effect of Propamocarb list agent to the cucumber downy mildew preventive effect under same concentrations.
Embodiment 68 control cucumber downy mildew drug effect test of field zone
Compound and 72.2% Propamocarb aqueous emulsion carry out the drug effect comparative test of sub-district, field to cucumber downy mildew.
Trial crops: cucumber (Tianjin spring No. 5)
Controlling object: cucumber downy mildew
Compound (I) and Propamocarb are pressed ratio respectively in ladle mixing, and the treatment dosage of mixture and Propamocarb is respectively 1000,500 and 250g a.i./hm 2, cucumber downy mildew is carried out drug effect test of field zone.Result of the test shows: compound (I) and Propamocarb mix, and begin medication when falling ill to the initial stage to cucumber downy mildew, 1000,500 and 250g a.i./hm 2Dosage under, through the secondary medication, its preventive effect is respectively 93.0,87.0 and 73.6%, obviously is better than the preventive effect of Propamocarb list agent.Illustrate that composition of the present invention has than obvious synergistic effect the control cucumber downy mildew.
Reagent agent Experimental concentration (ppm) Control efficiency (%)
72.2% Propamocarb 1000 73.7
500 52.5
250 21.5
Composition 1000 91.6
500 76.0
250 73.6
Test example 69 cucumber anthracnoses protection activity test
In the greenhouse embodiment 1 and 10% compound (I) aqueous suspension agent being carried out biologically active to cucumber anthracnose relatively tests.
Cucumber variety: precious poplar No. 5
Controlling object: cucumber anthracnose
Test method: the sandy loam of in plastic basin, packing into, sowing cucumber seed (precious poplar No. 5), it is stand-by during one heart stage cucumber seedling to be cultured to two leaves in the greenhouse, to try material places and carries out the blade face medicine liquid spray on the crop sprayer and handle, inoculation cucumber anthracnose spore after 24 hours, postvaccinal examination material place phytotron to cultivate 7 days investigation incidences of disease.
Active substance Concentration (ppm) Preventive effect (%)
Compound (I) 10 48.5
Carbendazim 100 27.4
Mixture 10+100 91.6
Result of the test shows: it is 91.6% to the preventive effect of cucumber downy mildew that compound (I) 5ppm adds carbendazim 100ppm, apparently higher than the preventive effect of two single agent.

Claims (9)

1. microbicide compositions is characterized in that containing (A group, B group and/or C group) bactericide in a kind of methoxy-methyl acrylate compounds (I) and the compound (II) as active component; Any one (A group, B group or the C group) bactericide that contains in methoxy-methyl acrylate compounds (I) and the compound (II) makes up, and the ratio of composition is 1: 100 to 20: 1 based on the parts by weight of active component.
2. microbicide compositions according to claim 1, it is characterized in that, also contain (A group, B group and/or C group) the another kind of combination of bactericide in the compound (II) in the composition, (A group, B group and/or C group) any two kinds of bactericide that promptly contain in methoxy-methyl acrylate compounds (I) and the above-claimed cpd (II) make up, and its ratio is 1 based on the parts by weight of active component: 1-20: 1-100 to 50: 1-20: 1.
3. microbicide compositions according to claim 1 and 2 is characterized in that: wherein contain (E) 2-[2-(2,5-dimethyl phenoxy methyl)-phenyl]-3-methoxy-methyl acrylate (ZJ0712, exploitation code name: ZJ0712).Its structural formula is:
Methoxy-methyl acrylate compounds-ZJ0712
The systemic fungicide that wherein contains in the compound (II) is.Kitazine, iprobenfos, procymidone, thiophanate-methyl, carbendazim, alkene azoles alcohol, nitrile bacterium azoles, triazolone, Tebuconazole, propiconazole, own azoles alcohol, two Flusilazole, metalaxyl, aliette, dimethomorph, white urea cyanogen, the spirit of Ben Shuan Ling Evil frost, cyprofuram, fenfuram, propionamide, zarilamid, fenfuram, furalaxyl, phosphorous acid or phosphorous acid disodium, benomyl; The protective fungicide that wherein contains in the compound (II) is tolelofos-methyl, fluazinam, prochloraz, tpn, captan, anilazine, Cupravit, ziram, presses down mould prestige, streptomycin, mancozeb, difoltan, Sulfur; Wherein contain soil fungicides tolelofos-methyl in the compound (II), pcnb, press down the spirit of mould Wei, Evil frost, enemy bacterium prestige Propamocarb, prothiocarb, hot oxazolone.
4. microbicide compositions according to claim 3 is characterized in that: the systemic fungicide that wherein contains in the compound (II) is: thiophanate-methyl, carbendazim, alkene azoles alcohol, nitrile bacterium azoles, triazolone, Tebuconazole, propiconazole, own azoles alcohol), benomyl, metalaxyl, aliette, dimethomorph, white urea cyanogen, the spirit of M 9834, Evil frost, Propamocarb, phosphorous acid or phosphorous acid disodium, in more than one; The protective fungicide that wherein contains in the compound (II) is: fluazinam, prochloraz, tpn, mancozeb, Sulfur; The soil fungicides that wherein contains in the compound (II) is: hot oxazolone, Propamocarb.
5. bactericidal composition according to claim 1 and 2 is characterized in that: the active component weight percentage in the composition is 0.5-95%.
6. Fungicidal compounds according to claim 1 is characterized in that: contain at least two kinds in the composition and carry, wherein at least a is surfactant.
7. Fungicidal compounds according to claim 1 is characterized in that composition of the present invention can be made into liquid agent, missible oil, suspending agent, aqueous suspension, microemulsion, water dispersion granule, emulsion, wetting powder, soluble powder and capsule.
8. microbicide compositions of the present invention can be used for preventing the plurality of plant diseases that caused by sac fungi, mastigomycetes and imperfect fungus etc.: as powdery mildew, brown spot, leaf spot, downy mildew, anthracnose, peronospora tabacina, and plant diseases such as gray mold.
9. composition of the present invention has protection, treatment and eradicant action concurrently to plant disease, for example can be used for various crop: plants such as cucumber, pumpkin, cucurbit, wheat class, strawberry, grape, tobacco, lupulus, peanut, potato, tomato, Chinese cabbage, capsicum, lettuce, wild cabbage, onion, citrus, banana, papaya papaw, Mango fruit, lichee and flowers.
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