CN1913787A - 在动物中促进生长的活体细菌的应用 - Google Patents
在动物中促进生长的活体细菌的应用 Download PDFInfo
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- CN1913787A CN1913787A CNA2005800039388A CN200580003938A CN1913787A CN 1913787 A CN1913787 A CN 1913787A CN A2005800039388 A CNA2005800039388 A CN A2005800039388A CN 200580003938 A CN200580003938 A CN 200580003938A CN 1913787 A CN1913787 A CN 1913787A
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Abstract
Description
名称 | 血清型 | 来源 |
JFF4(coliPROtec) | O8:K87 | 健康猪的粪便 |
JG1329 | O8:K87 | 猪的粪便 |
M226 | O9 | 猪的粪便 |
P03-7586(175) | O8 | 猪的粪便 |
pMK005 | O9 | 质粒pMK005编码F4 |
P82-862 | O115:KV165 | 猪的粪便 |
coliPROtec菌株的数据表 | |
使用“O”抗原并且在“Statens Serum Institut 5Artillerivej 2300哥本哈根S丹麦”通过血清型标准方法进行鉴定 | |
病原型 | 对下列毒素是阴性:·LT,STa,STb,STaH,Stx1,Stx2,VT2vp1,VT2vh,Aero,Tsh,CDT3,CDT4,CNF1,CNF2,H1yA,H1yC,Ehx,East1对下列毒力因子是阴性:·F5,F6,F18,F41,F17,P fimbriae,AIDA,AFA,SFA,CS31a,daaE,Paa,aggR,ARF/1,Eae,CFAI,CFAII(CS1coo),CFAII(CS3cst)由PCR和菌落杂交确定 |
菌毛表达介质 | |
对抗生素有抗性: | 氨苄青霉素,四环素,奇霉素,泰妙灵(tiamulin),泰乐菌素 |
对抗生素敏感: | 安普霉素,头孢噻呋,头孢噻吩,庆大霉素,新霉素,修饰/磺胺甲基唑(sulfamethoxazol) |
储存介质 | 冻干(冻干法)介质:5%dextran T-40,7%蔗糖,1%谷氨酸单钠 |
分离株来源 | 从正常猪的粪便中由大肠杆菌实验室分离,Fac.méd.vét.,Saint-Hyacinthe,1999。 |
试验组(n) | 说明 |
1(45) | 未处理的 |
2(45) | 用coliProtec(5E9/猪)处理的 |
天 | 说明 |
1 | 17-日龄的乳猪到达 |
1至4 | 适应阶段 |
5 | 利用单剂量coliPROtec或单独TSB(对照组)对动物进行处理 |
20 | 对动物称重;试验结束。 |
天 | 重量(Kg) | T-检验 | 第2组与第1组相比较(g) | |
第1组 | 第2组 | |||
5 | 6,053 | 6,137 | p=0.754 | +84 |
20 | 12,055 | 12,904 | p=0.020 | +849 |
天 | 日增重量(g) | T-检验 | 第2组与第1组相比较(g) | |
第1组 | 第2组 | |||
5至20 | 405 | 458 | p=0.007 | +53 |
组号(n) | 说明 |
1(7) | 未处理的猪 |
2(7) | 用F4-阴性非致病大肠杆菌菌株P82-862处理 |
3(7) | 用F4+非致病大肠杆菌JFF4菌株(coliPROtec)处理 |
4(7) | 用F4+非致病大肠杆菌JG1329菌株处理 |
5(7) | 用F4+非致病大肠杆菌M226菌株处理 |
6(7) | 用F4+非致病大肠杆菌P03-7586(175)菌株处理 |
7(7) | 用F4+非致病重组大肠杆菌pMK005菌株处理 |
天 | 说明 |
0 | 17日龄乳猪到达动物设施 |
1 | 对猪鉴定、分组和称重。按照动物的性别和重量进行分组。粪便采集用来评价F4,LT,STa和/或STb阳性大肠杆菌的排泄物(PCR) |
1和4 | 使用食管管道,向每只猪提供大约5E9 CFU的胰酶大豆肉汤(TSB)中的大肠杆菌。对照组只提供TSB。 |
1,4,9,14和17 | 动物称重;粪便采集用来评价F4,LT,STa和/或STb阳性大肠杆菌的排泄物(PCR) |
17 | 动物安乐死 |
F4阳性粪便的猪的数量 | 鉴别的其它毒力因子 | |
第1组*1第2组第3组第4组第5组第6组第7组 | 1121131 | LT和STbSTbLT和STbLT和STbLT和STbLT和STbSTb |
F4阳性粪便的猪的数量 | |||||
1天*1 | 4天 | 9天 | 14天 | 17天 | |
第1组*1第2组第3组第4组第5组第6组第7组 | 1121131 | 3247611 | 7767611 | 4356570 | 0050640 |
体重(Kg) | |||||
1天*1 | 4天 | 9天 | 14天 | 17天 | |
第1组*1第2组第3组第4组第5组第6组第7组 | 4,914,864,915,004,974,915,03 | 5,435,405,775,135,595,475,80 | 6,747,117,237,077,047,208,03 | 9,099,239,349,209,279,4110,20 | 10,2311,2010,9110,6010,4710,4611,23 |
组号.(N) | 说明 |
1(10) | 未处理的小鸡 |
2(10) | 用F4-阴性非致病大肠杆菌菌株P82-862处理 |
3(10) | 用F4+非致病大肠杆菌JFF4菌株(coliPROtec)处理 |
4(10) | 用F4+非致病大肠杆菌JG1329菌株处理 |
5(10) | 用F4+非致病大肠杆菌M226菌株处理 |
6(10) | 用F4+非致病大肠杆菌P03-7586(175)菌株处理 |
7(10) | 用F4+非致病重组大肠杆菌pMK005菌株处理 |
天数 | 说明 |
0 | 1日龄小鸡到达动物设施;对小鸡进行鉴定、称重和分组;粪便采集以用于评价F4、LT、STa和/或STb阳性大肠杆菌的排泄物(PCR) |
1和4 | 使用食管针向每只小鸡提供大约1E9 CFU胰酶大豆肉汤(TSB)中的大肠杆菌,对照组只接受TSB。 |
0,4,9,14,18,23和28 | 动物称重;评价F4、LT、STa和/或STb阳性大肠杆菌的排泄物(PCR) |
2,9,17和24 | 评价24小时饲料消耗 |
28 | 动物安乐死 |
组号:(N) | 说明 |
1(10) | 未处理的小鼠 |
2(10) | 用F4-阴性非致病大肠杆菌菌株P82-862处理 |
3(10) | 用F4+非致病大肠杆菌JFF4菌株(coliPROtec)处理 |
4(10) | 用F4+非致病大肠杆菌JG1329菌株处理 |
5(10) | 用F4+非致病大肠杆菌M226菌株处理 |
6(10) | 用F4+非致病大肠杆菌P03-7586(175)菌株处理 |
7(10) | 用F4+非致病大肠杆菌pMK005菌株处理 |
天数 | 说明 |
0 | 21日龄小鼠到达动物设施;小鼠的鉴定、分组和称重;每个处理组,5只雄性和5只雌性被分在两个笼子中。粪便采集用来评价F4、LT、STa和/或STb阳性大肠杆菌的排泄物(PCR) |
1和4 | 利用食管针向每只小鼠提供大约1E9 CFU处于胰酶大豆肉汤(TSB)中的大肠杆菌,对照组只接受TSB。 |
1,4,9,14,18,23和28 | 动物称重;评价从上一次称重的日子到这次称重日子的时间段内的饲料消耗。粪便被取样用于评价F4、LT、STa和/或STb阳性大肠杆菌的排泄物(PCR) |
28 | 动物安乐死 |
组 | 体重(g) | ||||||
0天 | 4天 | 9天 | 14天 | 18天 | 23天 | 28天 | |
1*1234567 | 16,7117,2017,3317,5418,0517,7717,79 | 21,0121,6721,9321,3921,6821,5220,88 | 23,6724,4024,4224,3724,4024,3723,44 | 24,9525,7225,8526,1225,7025,8324,03 | 26,1526,8127,1026,8727,4226,9226,15 | 27,3528,3227,8828,0928,8527,8927,41 | 28,2429,3828,9429,4829,9029,1328,29 |
组 | 各组的饲料转化率 | |
0-14天 | 14-28天 | |
1*1234567 | 7,306,506,416,627,407,048,44 | 18,3914,9618,3417,1114,1717,6513,15 |
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CA2649992A1 (en) * | 2006-05-01 | 2007-11-08 | University Of Manitoba | A colicinogenic strain of e. coli |
US8906668B2 (en) | 2012-11-23 | 2014-12-09 | Seres Health, Inc. | Synergistic bacterial compositions and methods of production and use thereof |
EP3904502A3 (en) | 2013-02-04 | 2022-02-23 | Seres Therapeutics, Inc. | Compositions and methods |
AU2014212004B2 (en) | 2013-02-04 | 2018-09-20 | Seres Therapeutics, Inc. | Compositions for treating or preventing or reducing the severity of clostridium difficile related diseases |
CA2906921A1 (en) | 2013-03-15 | 2014-09-18 | Seres Therapeutics, Inc. | Network-based microbial compositions and methods |
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BR112017017147B1 (pt) * | 2015-02-11 | 2024-02-20 | Prevtec Microbia Inc | Processo para fornecimento de escherichia coli (e. coli) viável embebida em uma matriz na forma de uma partícula |
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US20070218035A1 (en) | 2007-09-20 |
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