CN1907396A

CN1907396A - Medicine for treating cerebral hemorrhage

Info

Publication number: CN1907396A
Application number: CNA2006100370131A
Authority: CN
Inventors: 黄超权
Original assignee: Individual
Current assignee: Individual
Priority date: 2006-08-14
Filing date: 2006-08-14
Publication date: 2007-02-07
Anticipated expiration: 2026-08-14
Also published as: CN100384464C

Abstract

The invention relates to a medicinal composition for treating cerebral hemorrhage which is mainly prepared from the following raw materials (by weight portion), pachyrhizus root 8-12 parts, sarandra glabra nakai 10-20 parts, cortex acanthopanacis 10-15 parts, rheum officinale 6-20 parts, red sage root 15-25 parts, hairy holly root 10-20 parts, mulberry twig 20-30 parts, motherwort 10-15 parts, ligustrum japonicum 12-20 parts, achyranthes and cyathula root 10-20 parts, and acorus gramineus soland 10-15 parts.

Description

The medicine of treatment cerebral hemorrhage

Technical field

The present invention relates to a kind of medicine for the treatment of cerebral hemorrhage.

Background technology

Cerebral hemorrhage also is cerebral hemorrhage, be meant rupture of blood vessel in brain after, blood flows in the brain matter.About 80% patient occurs in cerebral hemisphere, and about 20% patient occurs in cerebellum and brain stem.The cause of disease of cerebral hemorrhage is a lot, can be divided into damaging and non-damage two big classes.Non-damage cerebral hemorrhage about 90% has hypertension history, in case hemorrhage, cause brain local blood circulation obstacle, cause the acute cerebral insult symptom, be common how with hemiplegia, aphasia, stupor etc.Therapeutic Method has two kinds, and a kind of is operation, and another kind is to take medicine.When in patient's brain during hematocele 40～100CC, usually adopt operation to open cranium, exist medical expense big, sequela is more serious, the mortality rate problem of higher, though the patient who has has kept life, Cranial nerve injury as birth trauma in various degree can appear in about 90% patient, causes to can't take care of oneself or become the plant man.When in patient's brain during hematocele 5～40CC, adopt intravenously administrable usually, about 30% patient can cure, and about 50% patient can't cure, and about 20% the patient state of an illness on the contrary can increase the weight of, even causes death, and its curative effect is low.In addition, the patient of hematocele is by taking Chinese patent medicine or Western medicine etc. in the brain, and its medicine time is long, and sb.'s illness took a favorable turn slowly, and cure rate generally has only 10～20%, and its curative effect is low equally.

Summary of the invention

Purpose of the present invention just provides a kind of in generation cerebral hemorrhage 20 days, and the treatment cerebral hemorrhage has the medicine of significant curative effect.

Harvest in Herba Melastomatis dodecandri root that the present invention selects for use another name PUDIJIN, mountain region, Herba Melastomatis dodecandri, floor file rattan, and the effect of promoting blood circulation and hemostasis is arranged; Herba Pileae Scriptae another name hill covered with grass coral, swollen joint peak, Psychotria rubra (Lour.) Poir. flower, synthetism lotus have promoting blood circulation to remove blood stasis; Radix Acanthopanacis Trifoliati is called white muscle flower, flaccid anemone, the circulation of qi promoting of olive fermented soya beans, salted or other wise dish energy, dissipating blood stasis; The cooling blood for hemostasis of Radix Cirsii Japonici another name field thistle energy, dissipating blood stasis for subsidence of swelling; Radix Salviae Miltiorrhizae another name salvia bowleyana Dunn, seven-star fiber crops, pale reddish brown Radix Salviae Miltiorrhizae, Radix Salviae simplicifoliae, Radix Salviae Miltiorrhizae have the effect that blood stasis removing is invigorated blood circulation; By rigorous prescription, can promoting blood circulation and hemostasis, blood circulation promoting and blood stasis dispelling, can reach vessel softening, the logical sanguimotor curative effect of cerebral blood vessel again again, so be the monarch drug in the prescription.Radix Ilicis Pubescentis another name fur tree is the key medicine of blood circulation and channel invigorating; Ramulus Mori has the effect in the sharp joint of collateral dredging; Radix Achyranthis Bidentatae another name Radix Achyranthis Bidentatae, Radix Achyranthis have the effect of invigorating blood circulation, stimulating the menstrual flow; Herba Leonuri another name Herba leonuri pseudoma cranthi can be invigorated blood circulation, be subsided a swelling.Pharmacological research proves: blood circulation promoting medicine can make blood become bright by dense, sticking, after blood becomes aquatic foods, and can unimpeded circulation in blood vessel.The combination of arteriosclerosis and tendons relaxing and meridians dredging, blood circulation promoting medicine and strong muscle medicine, clinical showing can strengthen, recover function of nervous system fast, and nerve and endovascular blood are normally moved, thereby makes neural must leading in reaching recurrence of disease at the same time next year, so be the ministerial drug in the prescription.Fructus Ligustri Lucidi another name Fructus Ilicis Purpureae, clearing away heat to improve acuity of vision, liver and kidney tonifying; Rhizoma Polygonati, Rhizoma Dioscoreae, Semen Euryales, Folium Perillae, Rhizoma Smilacis Glabrae pharmacology are: kidney is supported in spleen reinforcing, the function of the lung benefiting that promotes the production of body fluid, boosting qi and nourishing yin, spleen invigorating lung moistening, circulation of qi promoting dehumidifying, combination mutually, can strengthen and promote the function QI-blood circulation, the internal organs QI and blood is in harmonious proportion, mind could be recovered, appetite could strengthen, so be the adjuvant drug in the prescription.Rhizoma Acori Graminei another name Rhizoma Acori Graminei, is to adjust the principal agent of logical brain mind mind again at the eliminating phlegm that can refreshment is good for the stomach, has one's ideas straightened out, and is the messenger drug in the prescription.More than all medicines share and gather the merit that reaches cooling blood for hemostasis, dissipating blood stasis, vessel softening, dredge the meridian passage, consciousness and resuscitation restoring, good in strengthening stomach and tonifying kidney altogether.

In order to reach better therapeutic, medicine of the present invention also makes up with Herba Taxilli, Folium Perillae and Herba Verbenae.The Herba Taxilli another name is extensively parasitic, the parasitic tea in Wuzhou, and the merit of bone and muscle strengthening is arranged; Folium Perillae another name Huis Soviet Union has the cold expelling of inducing sweat, the regulating qi-flowing for harmonizing stomach effect; Herba Verbenae another name Canis familiaris L. stings grass, suitable JIANGCAO, Bermuda grass, Herba lespedezae pilosae, Ma Bancao, Agrimony and wind neck grass, promoting blood circulation to remove blood stasis, preventing the attack (or recurrence) of malaria, detoxifcation, inducing diuresis to remove edema.

Medicine of the present invention also can make up with Fructus glochidionis puberi(Herba Glochidii Puberi), Rhizoma Dioscoreae, Rhizoma Smilacis Glabrae, Semen Euryales, the Cortex Eucommiae, Pheretima and Rhizoma Polygonati.Fructus glochidionis puberi(Herba Glochidii Puberi) another name calabazilla, green pepper, golden GUFENG, the energy clearing away heat and cooling blood; Rhizoma Dioscoreae another name Rhizomadioscoreae, Rhizoma Dioscoreae summer-heat can spleen reinforcing be supported kidney, the kidney tonifying that promotes the production of body fluid, the kidney invigorating arresting seminal emission; Rhizoma Smilacis Glabrae another name Rhizoma Smilacis Glabrae, hard meal head can removing damp-heats, detoxifcation, circulation of qi promoting and in; Semen Euryales another name Caput Gallus domesticus, energy supplementing the kidney to control the nocturnal, spleen reinforcing antidiarrheal; The Cortex Eucommiae has the effect of bone and muscle strengthening; Pheretima can heat clearing away spasmolytic, the effect of logical brain network again; Rhizoma Polygonati another name RHIZOMA POLYGONATI ZINGIBERIFORME has the merit of spleen reinforcing lung moistening, supplementing QI and nourishing YIN, benefit marrow.

The present invention is mainly made by the raw material of following weight parts: 8～12 parts of Herba Melastomatis dodecandri roots, 10～20 parts of Herba Pileae Scriptaes, 10～15 parts of Radix Acanthopanacis Trifoliatis, 6～20 parts of Radix Cirsii Japonicis, 15～25 parts of Radix Salviae Miltiorrhizaes, 10～20 parts of Radix Ilicis Pubescentiss, 20～30 parts of Ramulus Moris, 10～15 parts of Herba Leonuris, 12～20 parts of Fructus Ligustri Lucidi, 10～20 parts of Radix Achyranthis Bidentataes, 10～15 parts of Rhizoma Acori Graminei.

The present invention also adds: 10～20 parts of Herba Taxillis, 10～15 parts of Folium Perillaes, 6～15 parts of Herba Verbenae.

The present invention also adds: 10～20 parts of Fructus glochidionis puberi(Herba Glochidii Puberi)s, 10～20 parts of Rhizoma Dioscoreaes, 10～20 parts of Rhizoma Smilacis Glabraes, 10～15 parts of Semen Euryaless, 10～15 parts of the Cortexs Eucommiae, 6～10 parts of Pheretimas, 15～20 parts of Rhizoma Polygonatis.

The present invention has the merit of hematocele, vessel softening, dredge the meridian passage, consciousness and resuscitation restoring, good in strengthening stomach and tonifying kidney in cooling blood for hemostasis, the quick blood stasis dispelling brain.No matter patient's brain inner product blood volume what, when not opening brainpan, the patient is in 2～20 days, as long as stable disease, even the plant man, the slotting stomach stream juice medicinal liquid that gavages and can swallow is taken medicine of the present invention, curative effect the best, effective percentage reaches 96.5%.

The present invention treats the clinical observation on the therapeutic effect of cerebral hemorrhage

1, data

1.1 diagnostic criteria: collect the complete medical history information of patient, clinical diagnosis is according to nineteen ninety-five the 4th cerebrovascular meeting in the whole nation, cerebrovascular classification diagnosis standard, and check through Cranial Computed Tomography or MRI to confirm: cerebral hemorrhage comprises cerebral hemorrhage, subarachnoid hemorrhage.

1.2 physical data

Be selected from the patients with cerebral hemorrhage of being in hospital 1～30 day in Guangdong Province's Meizhou City the People's Hospital in year April, in December, 1996～2006 and the People's Hospital, Pingyuan County, Guangdong Province, all meet the cerebral hemorrhage diagnostic criteria, be total to patients with cerebral hemorrhage 112 examples (male's 78 examples, women's 34 examples) that collection has been left hospital, oldest 88 years old, minimum 43 years old; 1 day 2 example of being in hospital, 2～10 days 60 examples of being in hospital, 11～20 days 25 examples of being in hospital, 21～30 days 25 examples of being in hospital.By hospital discharge certificate, CT report review conclusion is respectively putamen hemorrhage, thalamic hemorrhage, cerebral lobar hemorrhage, cerebellar hemorrhage, subarachnoid hemorrhage when leaving hospital.

1.3 clinical symptoms

In patients with cerebral hemorrhage 112 examples: can not take food stream juice, panplegia paralysis, persistent vegetative state 2 examples; Can feed flow juice gruel, panplegia paralysis 22 examples (wherein: male 14 examples, women 8 examples); Language celostomia, half body hemiplegia 46 examples (wherein: male 36 examples, women 10 examples); Can flow juice, upper limb hemiplegia 16 examples (wherein: each 8 example of men and women) for food; Can flow juice, lower limb hemiplegia 26 examples (wherein: male 19 examples, women 7 examples) for food.

In patients with cerebral hemorrhage 112 examples: intracranial hematocele 100CC 2 examples (wherein: each 1 example of men and women), can not take food stream juice, panplegia paralysis, persistent vegetative state; Putamen hemorrhage 10～30CC 25 examples, the hemiplegia of leaning to one side; Cerebral lobar hemorrhage 30～45CC 30 examples have headache, hemiplegia state; Pontine hemorrhage 25～45CC 16 examples, patient's upper limb hemiplegia, facial hemiparalysis, dysphagia; Cerebellar hemorrhage 20-48CC 26 examples, patient's dysphagia, slurred speech, lower limb hemiplegia; Subarachnoid hemorrhage 13 examples have headache, semicoma, tic, gatism, the blind state of vision.

2, Therapeutic Method

2.1 oral, restrain of the present invention medicine Baoshang with 280 every day, and each oral 150 milliliters, every day three times, taking medicine after meal, 30 days is a course of treatment.

Gavage, the patient of the stream juice of can not taking food inserts stomach tube earlier, the reuse syringe sucked 100～200 milliliters of nutritional solutions and directly pours in the stomach tube, gavaged stream juice nutritional solution every 5 hours, directly injected 150 milliliters of medicinal liquids in the stomach tube with syringe after 15 minutes, gavage every day three times, gavage 450 milliliters altogether.

2.2 criterion of therapeutical effect:

Cure: hemiplegic limb recovers the V level, and language performance does not have difficulty, and life can be taken care of oneself.

Produce effects: language performance is still not exclusively fluent, Myodynamia recovery III-IV level, and life can be taken care of oneself or half self-care.

Effectively: vital sign is normal, and hemiplegic limb takes a turn for the better, Myodynamia recovery II-III level, and language performance is unfluent, can't take care of oneself.

Invalid: as to die from complication, clinical death.

3, therapeutic outcome

The present invention treats patients with cerebral hemorrhage 112 examples, cures 94 examples, accounts for 83.9%; Produce effects 8 examples account for 7.1%; Effective 6 examples account for 5.4%; Invalid 4 examples account for 3.6%.

3.1 brain inner product blood volume in 100CC, the stream juice medicinal liquid as long as the patient can swallow, the heart, liver, spleen, stomach, kidney do not have serious pathological changes, can not open brainpan and perform an operation, oral medicine of the present invention has the hope of quick rehabilitation.

3.2 no matter patient's brain inner product blood volume what, when not opening brainpan, cerebral hemorrhage took place 2～20 days in the patient, as long as conditions of patients is stable, the stream juice medicinal liquid of swallowing is taken medicine of the present invention, curative effect the best.The patient took medicine 2～5 days, and clinical visible consciousness, mind, language recovery are fast; Took medicine 10～30 days, hemiplegia symptom takes a turn for the better fast, and trick can be stretched, can be bent, and finger is clenched fist strong, and the hemiplegia thigh and calf progressively recovers, and it is strong to stride.

3.3 the patient cerebral hemorrhage takes place 2～14 days, takes medicine of the present invention 30 days, cure rate reaches 83.9%; Cerebral hemorrhage took place 15～20 days in the patient, took medicine of the present invention 30 days, and effective percentage reaches 96.5%; Hematocele has complication in the brain, the heart, liver, spleen, stomach, the serious pathological changes of kidney, and invalid only accounts for 3.6%.

The specific embodiment

Below in conjunction with embodiment, the invention will be further described.

Embodiment one

Get Herba Melastomatis dodecandri root 8 grams, Herba Pileae Scriptae 10 grams, Radix Acanthopanacis Trifoliati 10 grams, Radix Cirsii Japonici 6 grams, Radix Salviae Miltiorrhizae 15 grams, Radix Ilicis Pubescentis 20 grams, Ramulus Mori 30 grams, Herba Leonuri 15 grams, Fructus Ligustri Lucidi 20 grams, Radix Achyranthis Bidentatae 20 grams, Rhizoma Acori Graminei 15 gram mixings, pulverize, drying, sterilization, packing is made powder.

Embodiment two

Get Herba Melastomatis dodecandri root 12 grams, Herba Pileae Scriptae 20 grams, Radix Acanthopanacis Trifoliati 15 grams, Radix Cirsii Japonici 20 grams, Radix Salviae Miltiorrhizae 25 grams, Radix Ilicis Pubescentis 10 grams, Ramulus Mori 20 grams, Herba Leonuri 10 grams, Fructus Ligustri Lucidi 12 grams, Radix Achyranthis Bidentatae 10 grams, Rhizoma Acori Graminei 10 grams, Herba Taxilli 10 grams, Folium Perillae 10 grams and Herba Verbenae 6 grams, method is routinely made tablet.

Embodiment three

Get Herba Melastomatis dodecandri root 10 grams, Herba Pileae Scriptae 15 grams, Radix Acanthopanacis Trifoliati 13 grams, Radix Cirsii Japonici 13 grams, Radix Salviae Miltiorrhizae 20 grams, Radix Ilicis Pubescentis 15 grams, Ramulus Mori 25 grams, Herba Leonuri 12 grams, Fructus Ligustri Lucidi 16 grams, Radix Achyranthis Bidentatae 15 grams, Rhizoma Acori Graminei 13 grams, Herba Taxilli 15 grams, Folium Perillae 12 grams, Herba Verbenae 11 grams, Fructus glochidionis puberi(Herba Glochidii Puberi) 15 grams, Rhizoma Dioscoreae 15 grams, Rhizoma Smilacis Glabrae 15 grams, Semen Euryales 13 grams, the Cortex Eucommiae 12 grams, Pheretima 8 grams and Rhizoma Polygonati 17 grams, method is routinely made capsule or oral liquid.

Claims

1, a kind of medicine for the treatment of cerebral hemorrhage is characterized in that mainly being made by the raw material of following weight parts:

10～15 parts of 10～20 parts of Radix Acanthopanacis Trifoliatis of 8～12 parts of Herba Pileae Scriptaes of Herba Melastomatis dodecandri root

10～20 parts of 15～25 portions of Radix Ilicis Pubescentiss of 6～20 parts of Radix Salviae Miltiorrhizaes of Radix Cirsii Japonici

12～20 parts of 10～15 parts of Fructus Ligustri Lucidi of 20～30 parts of Herba Leonuris of Ramulus Mori

10～15 parts of 10～20 parts of Rhizoma Acori Graminei of Radix Achyranthis Bidentatae

2, the medicine of treatment cerebral hemorrhage according to claim 1 is characterized in that also adding: 10～20 parts of Herba Taxillis, 10～15 parts of Folium Perillaes, 6～15 parts of Herba Verbenae.

3, the medicine of treatment cerebral hemorrhage according to claim 1 is characterized in that also adding: 10～20 parts of Fructus glochidionis puberi(Herba Glochidii Puberi)s, 10～20 parts of Rhizoma Dioscoreaes, 10～20 parts of Rhizoma Smilacis Glabraes, 10～15 parts of Semen Euryaless, 10～15 parts of the Cortexs Eucommiae, 6～10 parts of Pheretimas, 15～20 parts of Rhizoma Polygonatis.