CN1905875B - 吡啶*盐作为血管保护剂的用途 - Google Patents

吡啶*盐作为血管保护剂的用途 Download PDF

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CN1905875B
CN1905875B CN2005800017124A CN200580001712A CN1905875B CN 1905875 B CN1905875 B CN 1905875B CN 2005800017124 A CN2005800017124 A CN 2005800017124A CN 200580001712 A CN200580001712 A CN 200580001712A CN 1905875 B CN1905875 B CN 1905875B
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disease
purposes
chronic
blood vessel
atherosclerosis
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CN1905875A (zh
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J·戈比克
S·驰罗匹克
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Pharmena SpZOO
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Pharmena SpZOO
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    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/455—Nicotinic acids, e.g. niacin; Derivatives thereof, e.g. esters, amides
    • A—HUMAN NECESSITIES
    • A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
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    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/4406—Non condensed pyridines; Hydrogenated derivatives thereof only substituted in position 3, e.g. zimeldine
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    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/4425—Pyridinium derivatives, e.g. pralidoxime, pyridostigmine
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CN2005800017124A 2004-01-12 2005-01-07 吡啶*盐作为血管保护剂的用途 Expired - Lifetime CN1905875B (zh)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
PLP-364348 2004-01-12
PL04364348A PL364348A1 (en) 2004-01-12 2004-01-12 Application of quaternary pyridine salts as vessel protection agent
PLP364348 2004-01-12
PCT/EP2005/050057 WO2005067927A2 (en) 2004-01-12 2005-01-07 The use of quaternary pyridinium salts as vasoprotective agents

Publications (2)

Publication Number Publication Date
CN1905875A CN1905875A (zh) 2007-01-31
CN1905875B true CN1905875B (zh) 2010-07-28

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US (6) US7935717B2 (enExample)
EP (2) EP2279738A1 (enExample)
JP (2) JP5052138B2 (enExample)
CN (1) CN1905875B (enExample)
AT (1) ATE524179T1 (enExample)
AU (1) AU2005205066C1 (enExample)
CA (1) CA2547234C (enExample)
DK (1) DK1713480T3 (enExample)
ES (1) ES2372756T3 (enExample)
PL (2) PL364348A1 (enExample)
PT (1) PT1713480E (enExample)
RU (1) RU2366420C2 (enExample)
WO (1) WO2005067927A2 (enExample)

Families Citing this family (35)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
PL364348A1 (en) 2004-01-12 2005-07-25 PHARMENA Sp.z o.o. Application of quaternary pyridine salts as vessel protection agent
AU2006329564A1 (en) 2005-07-11 2007-07-05 Pharmena North America Inc. Formulations for treatment of lipoprotein abnormalities comprising a statin a statin and a methylnicotinamide derivative
EP1963270B1 (en) * 2005-12-09 2009-08-05 Cerecon AG Quaternary 3 -amido, n-methylpyridinium salts as anti -inflammatory agents
CA2657606A1 (en) 2006-03-08 2007-09-13 Cortria Corporation Combination therapy with non-selective cox inhibitors to prevent cox-related gastric injuries
CA2700585A1 (en) * 2006-10-18 2008-08-14 Dermena North America, Inc. Food extracts for treatment of lipoprotein abnormalities and skin diseases and skin disorders
PL381862A1 (pl) 2007-02-28 2008-09-01 Trigendo Spółka Z Ograniczoną Odpowiedzialnością Zastosowanie związków pirydyniowych i sposób leczenia
WO2009042440A1 (en) * 2007-09-28 2009-04-02 Cortria Corporation 1-methyl nicotinamide and derivatives for treatment of gastric injury
PL2211858T3 (pl) 2007-10-12 2015-06-30 Politechnika Lodzka Zastosowanie czwartorzędowych soli pirydyniowych do hamowania przerzutów nowotworowych
US8304439B1 (en) 2007-10-12 2012-11-06 Politechnika Lodzka Use of quaternary pyridinium salts as a therapeutic or preventing agent against ionizing radiation-induced damage
WO2009047290A1 (en) * 2007-10-12 2009-04-16 Politechnika Lodzka Use of quaternary pyridinium salts for radioprotection
US20110263659A1 (en) * 2008-05-06 2011-10-27 Cortria Corporation Analogs of 1-Methylnicotinamide
WO2010000673A1 (en) * 2008-07-01 2010-01-07 Politechnika Lódzka N'-nitroxyalkylnicotinamides for the treatment of cardiovascular diseases
US8575175B2 (en) 2008-07-23 2013-11-05 Toray Industries, Inc. Therapeutic agent for chronic renal failure
EP2186419A1 (en) * 2008-11-13 2010-05-19 Tchibo GmbH NMP-containing extract, a method of its production and uses thereof
RU2425672C1 (ru) * 2010-04-12 2011-08-10 Государственное образовательное учреждение высшего профессионального образования "Курский государственный медицинский университет Федерального агентства по здравоохранению и социальному развитию" Способ коррекции гипергомоцистеин-индуцированной эндотелиальной дисфункции смесью растворов гомеопатических разведений поликлональных кроличьих антител к эндотелиальной синтазе оксида азота человека - с12, с30, с200
KR101309576B1 (ko) * 2011-05-25 2013-09-17 연세대학교 산학협력단 대사물질을 이용한 심부전 바이오마커
PL226999B1 (pl) * 2013-06-11 2017-10-31 Univ Jagiellonski Azotan (III) 3 -karbamoilo -1-metylopirydyniowy, sposób jego otrzymywania izastosowanie
CN105771005A (zh) * 2016-03-24 2016-07-20 乐普（北京）医疗器械股份有限公司 一种抗风湿性血管狭窄药物支架及其制备方法和应用
WO2018015862A1 (en) 2016-07-18 2018-01-25 Pharmena S.A. 1-methylnicotinamide salts for use in raising the blood levels of adiponectin
ES2967074T3 (es) * 2016-07-18 2024-04-25 Pharmena S A 1 metilnicotinamida para el tratamiento de una enfermedad cardiovascular
CN118221546A (zh) * 2017-07-27 2024-06-21 密歇根大学董事会 纤维蛋白溶酶原活化物抑制因子-1（pai-1）抑制剂和使用方法
PL238932B1 (pl) * 2017-12-31 2021-10-18 Univ Jagiellonski Pochodne soli pirydyniowych oraz ich zastosowanie
PH12021551394B1 (en) * 2019-01-02 2024-04-26 Celagenex Res India Pvt Ltd Potent synergistic compositions of vasoactive mediators enhancers for improving vascular endothelial function
WO2021205341A1 (en) 2020-04-07 2021-10-14 Pharmena S.A. 1-methylnicotinamide for the prevention/treatment of inflammatory airway diseases
EP4213821A2 (en) * 2020-09-21 2023-07-26 The Regents of the University of California Immunological effects of metabolites
CN115837023B (zh) * 2023-02-20 2023-05-16 中山大学附属第八医院（深圳福田） 1-甲基烟酰胺在制备抗血管钙化药物中的应用
US20240350475A1 (en) * 2023-04-13 2024-10-24 University Of South Carolina Trigonelline mitigates cardiomyopathy caused by sars-cov-2 spike protein under obesity
PL447656A1 (pl) * 2024-01-31 2025-08-04 Politechnika Poznańska Nowe czwartorzędowe sole amoniowe zawierające anion pochodzący od kwasu nikotynowego oraz kation N-alkilonikotynamidowy, sposób ich otrzymywania oraz zastosowanie jako substancje o aktywności przeciwbakteryjnej
PL248942B1 (pl) * 2024-01-31 2026-02-16 Politechnika Poznanska Czwartorzędowe sole amoniowe zawierające anion 2-furanokarboksylanowy i kation będący alkilową pochodną nikotynamidu, sposób ich otrzymywania i zastosowanie jako środki myjąco-dezynfekujące
PL449092A1 (pl) * 2024-07-01 2026-01-05 Uniwersytet Jagielloński Synergiczna kombinacja 1-metylonikotynamidu (MNA) i witaminy K do zastosowania w leczeniu lub zapobieganiu powikłaniom sercowo-naczyniowym terapii przeciwnowotworowych
PL450543A1 (pl) * 2024-12-11 2026-06-15 Politechnika Poznańska Czwartorzędowe sole amoniowe z kationem 3-karbamoilo-1-alkilopirydyniowym i anionem (R)-migdalanowym, sposób ich otrzymywania oraz zastosowanie jako substancje o aktywności przeciwbakteryjnej
PL450542A1 (pl) * 2024-12-11 2026-06-15 Politechnika Poznańska Czwartorzędowe sole amoniowe zawierające kation 3-karbamoiIo-1-alkilopirydyniowy i anion 4- aminobenzoesanowy, sposób ich otrzymywania i zastosowanie jako środki bakteriobójcze
PL450544A1 (pl) * 2024-12-11 2026-06-15 Politechnika Poznańska Czwartorzędowe sole amoniowe z kationem 3-karbamoilo-1-alkilopirydyniowym i anionem (S)-migdalanowym, sposób ich otrzymywania oraz zastosowanie jako substancje o aktywności przeciwbakteryjnej
PL452423A1 (pl) * 2025-06-20 2026-08-03 Politechnika Poznańska Sposób określania właściwości przeciwzapalnych czwartorzędowych soli amoniowych zawierających kation 3-karbamoilo-1-alkilopirydyniowy i anion 4-aminobenzoesanowy z użyciem albuminy jaja kurzego
PL452422A1 (pl) * 2025-06-20 2026-08-03 Politechnika Poznańska Sposób określania właściwości przeciwzapalnych czwartorzędowych soli amoniowych zawierających anion pochodzący od kwasu nikotynowego oraz kation N-alkilonikotynamidowy z użyciem albuminy jaja kurzego

Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2000040559A1 (en) * 1999-01-07 2000-07-13 Technical University Of Lodz Compositions for the treatment of skin diseases

Family Cites Families (23)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE840698C (de) * 1949-07-12 1952-06-05 Cilag Aktiengesellschaft Verfahren zur herstellung neuer derivate des nicotinsaureamids
GB675430A (en) 1949-07-12 1952-07-09 Cilag Ltd Novel quaternary nicotinic acid amide derivatives and production thereof
US5260305A (en) * 1988-12-12 1993-11-09 E. R. Squibb & Sons, Inc. Combination of pravastatin and nicotinic acid or related acid and method for lowering serum cholesterol using such combination
US20060263428A1 (en) * 1993-09-20 2006-11-23 Eugenio Cefali Methods for treating hyperlipidemia with intermediate release nicotinic acid compositions having unique biopharmaceutical characteristics
US6746691B2 (en) * 1993-09-20 2004-06-08 Kos Pharmaceuticals, Inc. Intermediate release nicotinic acid compositions for treating hyperlipidemia having unique biopharmaceutical characteristics
US6676967B1 (en) * 1993-09-20 2004-01-13 Kos Pharmaceuticals, Inc. Methods for reducing flushing in individuals being treated with nicotinic acid for hyperlipidemia
US6818229B1 (en) * 1993-09-20 2004-11-16 Kos Pharmaceuticals, Inc. Intermediate release nicotinic acid compositions for treating hyperlipidemia
US6406715B1 (en) * 1993-09-20 2002-06-18 Kos Pharmaceuticals, Inc. Intermediate release nicotinic acid compositions for treating hyperlipidemia having unique urinary metabolite profiles
US6129930A (en) * 1993-09-20 2000-10-10 Bova; David J. Methods and sustained release nicotinic acid compositions for treating hyperlipidemia at night
US20030161880A1 (en) * 1997-03-06 2003-08-28 Kos Pharmaceuticals, Inc. Intermediate release nicotinic acid compositions for treating hyperlipidemia having unique biopharmaceutical characteristics
US20010006644A1 (en) 1997-07-31 2001-07-05 David J. Bova Combinations of hmg-coa reductase inhibitors and nicotinic acid and methods for treating hyperlipidemia once a day at night
US6469035B1 (en) * 1997-07-31 2002-10-22 Eugenio A. Cefali Methods of pretreating hyperlipidemic individuals with a flush inhibiting agent prior to the start of single daily dose nicotinic acid therapy to reduce flushing provoked by nicotinic acid
IE970731A1 (en) * 1997-10-07 2000-10-04 Fuisz Internat Ltd Product and method for the treatment of hyperlipidemia
JP2002255846A (ja) * 2001-02-26 2002-09-11 Sunstar Inc 経口組成物
US20050130990A1 (en) * 2001-03-23 2005-06-16 Universite Laval Nicotinic receptor agonists for the treatment of inflammatory diseases
CA2341952A1 (en) * 2001-03-23 2002-09-23 Universite Laval Nicotinic receptor agonists for the treatment of inflammatory pulmonary diseases
US8039459B2 (en) * 2004-07-15 2011-10-18 Universite Laval Nicotinic receptor agonists for the treatment of inflammatory diseases
US7153870B2 (en) * 2003-07-25 2006-12-26 Pfizer Inc. Nicotinamide derivatives useful as PDE4 inhibitors
PL364348A1 (en) 2004-01-12 2005-07-25 PHARMENA Sp.z o.o. Application of quaternary pyridine salts as vessel protection agent
EP1811996A1 (en) 2004-11-05 2007-08-01 Arena Pharmaceuticals, Inc. Compositions for treating flushing and lipid-associated disorders comprising niacin receptor partial agonists
AU2006329564A1 (en) 2005-07-11 2007-07-05 Pharmena North America Inc. Formulations for treatment of lipoprotein abnormalities comprising a statin a statin and a methylnicotinamide derivative
CA2700585A1 (en) 2006-10-18 2008-08-14 Dermena North America, Inc. Food extracts for treatment of lipoprotein abnormalities and skin diseases and skin disorders
PL381862A1 (pl) * 2007-02-28 2008-09-01 Trigendo Spółka Z Ograniczoną Odpowiedzialnością Zastosowanie związków pirydyniowych i sposób leczenia

Patent Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2000040559A1 (en) * 1999-01-07 2000-07-13 Technical University Of Lodz Compositions for the treatment of skin diseases

Non-Patent Citations (8)

* Cited by examiner, † Cited by third party
Title
FILETTI, S. ET AL.Insulin receptor down-regulation prevention at a postreceptorsite.ENDOCRINOLOGY108 6.1981,108(6),2409-11.
FILETTI,S.ET AL.Insulin receptor down-regulation prevention at a postreceptorsite.ENDOCRINOLOGY108 6.1981,108(6),2409-11. *
FUKUSHIMA T ET AL.RADICAL FORMATION SITE OF CEREBRAL COMPLEXIAND PARKINSON＇S DISEASE.JOURNAL OF NEUROSCIENCE RESERRCH42.1995,42385-390. *
FUKUSHIMA,TETSUHITO et al.Possible role of 1-methylnicotinamide in thepathogenesisofParkinson＇s disease.Experimental and Toxicolog Pathology53 6.2002,53(6),469-473.
FUKUSHIMA,TETSUHITO et al.Possible role of 1-methylnicotinamide in thepathogenesisofParkinson＇s disease.Experimental and Toxicolog Pathology53 6.2002,53(6),469-473. *
Jerzy et al.1-METHYLNICOTINAMIDE: APOTENTANTI-INELAMMATORY AGENT OF VITAMINORIGIN.Polish Journal of Pharmacology55.2003,55109-112. *
LEA MA ET AL.EFFECTS OF NICOTINAMIDE AND STRUCTURALANALOGS ON DAN SYNTHESIS AND CELLULARPERLICATION OF RAT HEPATOMA CELLS.CANCER BIOCHEMISTRY BIOPHYSICS, GORDON AND BREACH SCIENCE PUBLISHER7 3.1984,7(3),195-202.
LEA MA ET AL.EFFECTS OF NICOTINAMIDE AND STRUCTURALANALOGS ON DAN SYNTHESIS AND CELLULARPERLICATION OF RAT HEPATOMA CELLS.CANCER BIOCHEMISTRY BIOPHYSICS, GORDON AND BREACH SCIENCE PUBLISHER7 3.1984,7(3),195-202. *

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