CN1905875B - 吡啶*盐作为血管保护剂的用途 - Google Patents
吡啶*盐作为血管保护剂的用途 Download PDFInfo
- Publication number
- CN1905875B CN1905875B CN2005800017124A CN200580001712A CN1905875B CN 1905875 B CN1905875 B CN 1905875B CN 2005800017124 A CN2005800017124 A CN 2005800017124A CN 200580001712 A CN200580001712 A CN 200580001712A CN 1905875 B CN1905875 B CN 1905875B
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- Prior art keywords
- disease
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- blood vessel
- chronic
- coronary
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- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
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- JUJWROOIHBZHMG-UHFFFAOYSA-N Pyridine Chemical class C1=CC=NC=C1 JUJWROOIHBZHMG-UHFFFAOYSA-N 0.000 title abstract 2
- 230000002666 vasoprotective effect Effects 0.000 title abstract 2
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 claims abstract 25
- 201000010099 disease Diseases 0.000 claims abstract 24
- 208000035150 Hypercholesterolemia Diseases 0.000 claims abstract 4
- 208000006575 hypertriglyceridemia Diseases 0.000 claims abstract 4
- 230000007812 deficiency Effects 0.000 claims abstract 2
- KAQKFAOMNZTLHT-VVUHWYTRSA-N epoprostenol Chemical compound O1C(=CCCCC(O)=O)C[C@@H]2[C@@H](/C=C/[C@@H](O)CCCCC)[C@H](O)C[C@@H]21 KAQKFAOMNZTLHT-VVUHWYTRSA-N 0.000 claims abstract 2
- 229960001123 epoprostenol Drugs 0.000 claims abstract 2
- 230000036542 oxidative stress Effects 0.000 claims abstract 2
- 230000002792 vascular Effects 0.000 claims abstract 2
- 210000004204 blood vessel Anatomy 0.000 claims 7
- 201000001320 Atherosclerosis Diseases 0.000 claims 6
- 230000001684 chronic effect Effects 0.000 claims 5
- 239000002552 dosage form Substances 0.000 claims 5
- 239000003223 protective agent Substances 0.000 claims 5
- 208000006545 Chronic Obstructive Pulmonary Disease Diseases 0.000 claims 4
- 208000019423 liver disease Diseases 0.000 claims 4
- 208000007107 Stomach Ulcer Diseases 0.000 claims 3
- 208000007536 Thrombosis Diseases 0.000 claims 3
- 208000000718 duodenal ulcer Diseases 0.000 claims 3
- 201000005917 gastric ulcer Diseases 0.000 claims 3
- 210000002784 stomach Anatomy 0.000 claims 3
- 210000000709 aorta Anatomy 0.000 claims 2
- 210000001367 artery Anatomy 0.000 claims 2
- 208000029078 coronary artery disease Diseases 0.000 claims 2
- 239000003814 drug Substances 0.000 claims 2
- 210000003038 endothelium Anatomy 0.000 claims 2
- 208000002815 pulmonary hypertension Diseases 0.000 claims 2
- CRJFOPZHQMBHNQ-UHFFFAOYSA-N 1-methyl-2h-pyridine-3-carboxamide Chemical class CN1CC(C(N)=O)=CC=C1 CRJFOPZHQMBHNQ-UHFFFAOYSA-N 0.000 claims 1
- 208000004476 Acute Coronary Syndrome Diseases 0.000 claims 1
- 208000033386 Buerger disease Diseases 0.000 claims 1
- 206010014522 Embolism venous Diseases 0.000 claims 1
- 206010019799 Hepatitis viral Diseases 0.000 claims 1
- 206010049418 Sudden Cardiac Death Diseases 0.000 claims 1
- 206010043540 Thromboangiitis obliterans Diseases 0.000 claims 1
- 230000001154 acute effect Effects 0.000 claims 1
- 239000002473 artificial blood Substances 0.000 claims 1
- 230000002612 cardiopulmonary effect Effects 0.000 claims 1
- 230000007211 cardiovascular event Effects 0.000 claims 1
- 206010008118 cerebral infarction Diseases 0.000 claims 1
- 208000026106 cerebrovascular disease Diseases 0.000 claims 1
- 238000007887 coronary angioplasty Methods 0.000 claims 1
- 235000015872 dietary supplement Nutrition 0.000 claims 1
- 210000001035 gastrointestinal tract Anatomy 0.000 claims 1
- 238000001631 haemodialysis Methods 0.000 claims 1
- 230000000322 hemodialysis Effects 0.000 claims 1
- 125000002887 hydroxy group Chemical group [H]O* 0.000 claims 1
- 150000002500 ions Chemical class 0.000 claims 1
- 230000000302 ischemic effect Effects 0.000 claims 1
- 239000002184 metal Substances 0.000 claims 1
- 208000010125 myocardial infarction Diseases 0.000 claims 1
- 235000016709 nutrition Nutrition 0.000 claims 1
- 230000035764 nutrition Effects 0.000 claims 1
- 238000001356 surgical procedure Methods 0.000 claims 1
- 230000009885 systemic effect Effects 0.000 claims 1
- 210000003437 trachea Anatomy 0.000 claims 1
- 208000004043 venous thromboembolism Diseases 0.000 claims 1
- 201000001862 viral hepatitis Diseases 0.000 claims 1
- 206010048554 Endothelial dysfunction Diseases 0.000 abstract 1
- 230000008694 endothelial dysfunction Effects 0.000 abstract 1
- 230000003511 endothelial effect Effects 0.000 abstract 1
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- A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
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- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- Veterinary Medicine (AREA)
- Medicinal Chemistry (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- General Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Epidemiology (AREA)
- Diabetes (AREA)
- Hematology (AREA)
- Neurology (AREA)
- Cardiology (AREA)
- Heart & Thoracic Surgery (AREA)
- Biomedical Technology (AREA)
- Obesity (AREA)
- Neurosurgery (AREA)
- Nutrition Science (AREA)
- Pulmonology (AREA)
- Food Science & Technology (AREA)
- Mycology (AREA)
- Polymers & Plastics (AREA)
- Urology & Nephrology (AREA)
- Endocrinology (AREA)
- Vascular Medicine (AREA)
- Ophthalmology & Optometry (AREA)
- Physiology (AREA)
- Gynecology & Obstetrics (AREA)
- Oncology (AREA)
- Psychology (AREA)
- Emergency Medicine (AREA)
- Psychiatry (AREA)
- Gastroenterology & Hepatology (AREA)
Applications Claiming Priority (4)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| PLP364348 | 2004-01-12 | ||
| PLP-364348 | 2004-01-12 | ||
| PL04364348A PL364348A1 (en) | 2004-01-12 | 2004-01-12 | Application of quaternary pyridine salts as vessel protection agent |
| PCT/EP2005/050057 WO2005067927A2 (en) | 2004-01-12 | 2005-01-07 | The use of quaternary pyridinium salts as vasoprotective agents |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| CN1905875A CN1905875A (zh) | 2007-01-31 |
| CN1905875B true CN1905875B (zh) | 2010-07-28 |
Family
ID=34793495
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN2005800017124A Expired - Lifetime CN1905875B (zh) | 2004-01-12 | 2005-01-07 | 吡啶*盐作为血管保护剂的用途 |
Country Status (13)
| Country | Link |
|---|---|
| US (6) | US7935717B2 (enExample) |
| EP (2) | EP1713480B1 (enExample) |
| JP (2) | JP5052138B2 (enExample) |
| CN (1) | CN1905875B (enExample) |
| AT (1) | ATE524179T1 (enExample) |
| AU (1) | AU2005205066C1 (enExample) |
| CA (1) | CA2547234C (enExample) |
| DK (1) | DK1713480T3 (enExample) |
| ES (1) | ES2372756T3 (enExample) |
| PL (2) | PL364348A1 (enExample) |
| PT (1) | PT1713480E (enExample) |
| RU (1) | RU2366420C2 (enExample) |
| WO (1) | WO2005067927A2 (enExample) |
Families Citing this family (28)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| PL364348A1 (en) | 2004-01-12 | 2005-07-25 | PHARMENA Sp.z o.o. | Application of quaternary pyridine salts as vessel protection agent |
| ATE548035T1 (de) | 2005-07-11 | 2012-03-15 | Cortria Corp | Formulierungen zur behandlung von lipoprotein- anormalitäten mit einem statin- und einem methylnicotinamid-derivat |
| US20080249140A1 (en) * | 2005-12-09 | 2008-10-09 | Jacques Gosteli | Quaternary 3 -Amido, N-Methylpyridinium Salts as Anti-Inflammatory Agents |
| ES2418153T3 (es) | 2006-03-08 | 2013-08-12 | Cortria Corporation | Terapia de combinación con inhibidores no selectivos de COX para prevenir lesiones gástricas relacionadas con COX |
| EP2079471A2 (en) * | 2006-10-18 | 2009-07-22 | Dermena | Food extracts containing n-methylnicotinamide for treatment of lipoprotein abnormalities and skin diseases and disorders |
| PL381862A1 (pl) * | 2007-02-28 | 2008-09-01 | Trigendo Spółka Z Ograniczoną Odpowiedzialnością | Zastosowanie związków pirydyniowych i sposób leczenia |
| WO2009042440A1 (en) * | 2007-09-28 | 2009-04-02 | Cortria Corporation | 1-methyl nicotinamide and derivatives for treatment of gastric injury |
| PL2211857T3 (pl) * | 2007-10-12 | 2012-11-30 | Politechnika Lodzka | Zastosowanie czwartorzędowych soli pirydyniowych do radioprotekcji |
| PL2211858T3 (pl) | 2007-10-12 | 2015-06-30 | Politechnika Lodzka | Zastosowanie czwartorzędowych soli pirydyniowych do hamowania przerzutów nowotworowych |
| US8304439B1 (en) | 2007-10-12 | 2012-11-06 | Politechnika Lodzka | Use of quaternary pyridinium salts as a therapeutic or preventing agent against ionizing radiation-induced damage |
| AU2009244395A1 (en) * | 2008-05-06 | 2009-11-12 | Cortria Corporation | 1-methylnicotinamide analogs |
| EP2307380B1 (en) * | 2008-07-01 | 2012-10-24 | Politechnika Lódzka | N'-nitroxyalkylnicotinamides for the treatment of cardiovascular diseases |
| WO2010010909A1 (ja) | 2008-07-23 | 2010-01-28 | 東レ株式会社 | 慢性腎不全処置剤 |
| EP2186419A1 (en) * | 2008-11-13 | 2010-05-19 | Tchibo GmbH | NMP-containing extract, a method of its production and uses thereof |
| RU2425672C1 (ru) * | 2010-04-12 | 2011-08-10 | Государственное образовательное учреждение высшего профессионального образования "Курский государственный медицинский университет Федерального агентства по здравоохранению и социальному развитию" | Способ коррекции гипергомоцистеин-индуцированной эндотелиальной дисфункции смесью растворов гомеопатических разведений поликлональных кроличьих антител к эндотелиальной синтазе оксида азота человека - с12, с30, с200 |
| KR101309576B1 (ko) * | 2011-05-25 | 2013-09-17 | 연세대학교 산학협력단 | 대사물질을 이용한 심부전 바이오마커 |
| PL226999B1 (pl) * | 2013-06-11 | 2017-10-31 | Univ Jagiellonski | Azotan (III) 3 -karbamoilo -1-metylopirydyniowy, sposób jego otrzymywania izastosowanie |
| CN105771005A (zh) * | 2016-03-24 | 2016-07-20 | 乐普（北京）医疗器械股份有限公司 | 一种抗风湿性血管狭窄药物支架及其制备方法和应用 |
| WO2018015862A1 (en) | 2016-07-18 | 2018-01-25 | Pharmena S.A. | 1-methylnicotinamide salts for use in raising the blood levels of adiponectin |
| AU2017298648B2 (en) * | 2016-07-18 | 2023-05-11 | Pharmena S.A. | 1-methylnicotinamide for the treatment of diseases associated with C-reactive protein |
| CA3070303A1 (en) * | 2017-07-27 | 2019-01-31 | The Regents Of The University Of Michigan | Plasminogen activator inhibitor-1 (pai-1) inhibitor and method of use |
| PL238932B1 (pl) * | 2017-12-31 | 2021-10-18 | Univ Jagiellonski | Pochodne soli pirydyniowych oraz ich zastosowanie |
| MY210174A (en) * | 2019-01-02 | 2025-08-30 | Celagenex Res India Pvt Ltd | Potent synergistic compositions of vasoactive mediators enhancers for improving vascular endothelial function |
| WO2021205341A1 (en) | 2020-04-07 | 2021-10-14 | Pharmena S.A. | 1-methylnicotinamide for the prevention/treatment of inflammatory airway diseases |
| JP2023542340A (ja) * | 2020-09-21 | 2023-10-06 | ザ リージェンツ オブ ザ ユニバーシティ オブ カリフォルニア | 代謝物の免疫学的作用 |
| CN115837023B (zh) * | 2023-02-20 | 2023-05-16 | 中山大学附属第八医院（深圳福田） | 1-甲基烟酰胺在制备抗血管钙化药物中的应用 |
| PL447657A1 (pl) * | 2024-01-31 | 2025-08-04 | Politechnika Poznańska | Czwartorzędowe sole amoniowe zawierające anion 2-furanokarboksylanowy i kation będący alkilową pochodną nikotynamidu, sposób ich otrzymywania i zastosowanie jako środki myjąco-dezynfekujące |
| PL447656A1 (pl) * | 2024-01-31 | 2025-08-04 | Politechnika Poznańska | Nowe czwartorzędowe sole amoniowe zawierające anion pochodzący od kwasu nikotynowego oraz kation N-alkilonikotynamidowy, sposób ich otrzymywania oraz zastosowanie jako substancje o aktywności przeciwbakteryjnej |
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| WO2000040559A1 (en) * | 1999-01-07 | 2000-07-13 | Technical University Of Lodz | Compositions for the treatment of skin diseases |
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