CN1899330A - Astringing and diarrhea relieving oral dispersion tablet preparation for treating acute and chronic diarrhea gastritis and preparing method - Google Patents
Astringing and diarrhea relieving oral dispersion tablet preparation for treating acute and chronic diarrhea gastritis and preparing method Download PDFInfo
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- CN1899330A CN1899330A CN 200610045505 CN200610045505A CN1899330A CN 1899330 A CN1899330 A CN 1899330A CN 200610045505 CN200610045505 CN 200610045505 CN 200610045505 A CN200610045505 A CN 200610045505A CN 1899330 A CN1899330 A CN 1899330A
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Abstract
The present invention discloses a kind of astringing and diarrhea relieving orally taken dispersive tablet and its preparation process. The tablet is prepared with the main material including montmorillonite and rhizome of featherleaf rodgersflower and supplementary material including filler, disintegrating agent, corrective and flow aid in certain weight proportion. The astringing and diarrhea relieving orally taken dispersive tablet is used in treating acute and chronic diarrhea, gastritis, esophagitis, colitis, GERD, etc of adult and children.
Description
Technical field
The present invention relates to a kind of relieving diarrhea with astringents oral dispersion tablet preparation, specifically a kind of relieving diarrhea with astringents oral dispersion tablet preparation and preparation method for the treatment of acute and chronic diarrhoea gastritis.
Background technology
Montmorillonitum is used for the treatment of acute and chronic diarrhea as the adsorbent of the agent of a kind of digestive tract protection efficiently and viral pathogenic bacteria and toxin thereof and has been used a lot of years at home and abroad.No matter be, shown that all its distinctive mucosa protective effect reaches the repair to gastrointestinal epithelial cells to acute and chronic diarrhea or to digesting the treatment of the various inflammation of mucous membrane.This effect is that other anti-diarrheals are unexistent.Montmorillonitum has powerful stationkeeping ability.And the function of unrestraint enterokinesia, therefore, it is external that it can fix the absorption of enteral attack factor and carry eliminating, and it is trapped in the enteric cavity.Can not cause also that enteral liquid stays amasss in enteric cavity, causes body fluid to run off.What Montmorillonitum was brought into play is the intestinal local action, not by intestinal absorption, so without any side effects.
Rhizoma Rodgersiae is the Miao Ethnomedicine conventional crude drugs, and nature and flavor are bitter, puckery, flat.Function cures mainly, and is analgesic, dispels the wind convergence.Be used for enteritis, dysentery, traumatic hemorrhage.Montmorillonitum and Rhizoma Rodgersiae associating prescription help the recovery of gastrointestinal function, we can say that this drug combination is current treatment diarrheal preferred plan.
At present, the pharmaceutical dosage form that uses relieving diarrhea with astringents to loose on the market is powder, and there is certain deficiency in this dosage form, take inconvenience, dosage also is not easy to grasp, and adds water and stirs, and is oral, grittiness, bilgy odour are arranged, the patient should not accept, and when particularly infant and teenager decrement are taken, has certain difficulty, dosage is inaccurate, can not obtain ideal curative effect.
Summary of the invention
Technical assignment of the present invention provides a kind of relieving diarrhea with astringents oral dispersion tablet preparation and preparation method for the treatment of acute and chronic diarrhoea gastritis.
The relieving diarrhea with astringents oral dispersion tablet preparation of the acute and chronic diarrhoea gastritis of treatment of the present invention comprises major ingredient, adjuvant and wetting agent, and major ingredient comprises: Montmorillonitum and Rhizoma Rodgersiae; Adjuvant comprises filler, disintegrating agent, correctives and fluidizer; Wetting agent is: ethanol;
The weight proportion of each raw material is: 100 parts of Montmorillonitums, 166 parts of Rhizoma Rodgersiae, filler 3-20 part, disintegrating agent 1-8 part, correctives 0.1-5 part, fluidizer 0.1-0.5 part, ethanol 60-100 part.
The optimization weight proportion of each raw material is: 100 parts of Montmorillonitums, 166 parts of Rhizoma Rodgersiae, filler 4-10 part, disintegrating agent 4-7 part, correctives 1-4 part, fluidizer 0.2-0.4 part, ethanol 70-90 part.
The optimum weight proportioning of each raw material is: 100 parts of Montmorillonitums, 166 parts of Rhizoma Rodgersiae, 8 parts of filleies, 6 parts of disintegrating agents, 2.5 parts of correctivess, 0.3 part of fluidizer, 80 parts of ethanol.
Above consumption is the raw material weight ratio, and those skilled in the art can be according to producing needs, enlarges arbitrarily or dwindles according to aforementioned proportion, all belongs within protection scope of the present invention.
Disintegrating agent be in disintegrating agent with add disintegrating agent, in be any one or two kinds of combinations in carboxymethyl starch sodium and the cross-linking sodium carboxymethyl cellulose with disintegrating agent; Add disintegrating agent and be any one or two kinds of combinations in carboxymethyl starch sodium and the cross-linking sodium carboxymethyl cellulose; In be 1 with disintegrating agent and the weight ratio that adds disintegrating agent: 1-3; Filler be in microcrystalline Cellulose, carboxymethyl starch and the starch any one, two or more combination; Correctives is a kind of, two or more combination in stevioside, aspartame, the vanillin; Fluidizer is a kind of, two or more combination in microcrystalline silicon, magnesium stearate, the Pulvis Talci; Wetting agent ethanol is 75%-95% ethanol; Said preparation is for disperseing Formulation.
The preparation process of this dispersible tablet formulation is: it is standby to take by weighing required weight Montmorillonitum; After taking by weighing Rhizoma Rodgersiae in proportion, Rhizoma Rodgersiae is ground into coarse powder, with 80% soak with ethanol three times, soaked 48 hours for the first time, 80% ethanol consumption is 10 times of amounts of Rhizoma Rodgersiae weight; Respectively soaked 24 hours for the second time, for the third time, 80% ethanol consumption is 5 times of amounts of Rhizoma Rodgersiae weight; Merge soak afterwards, decompression recycling ethanol also is concentrated into the extractum that relative density is 1.10～1.20 (50 ℃-60 ℃), adds hydrochloric acid and regulates pH value to 2; Standing over night filters afterwards, and filtrate decompression is concentrated into the thick paste that relative density is 1.20～1.40 (50 ℃～60 ℃), adds 5 times of amount 80% ethanol again and makes dissolving, add activated carbon decolorizing, filter, filtrate is concentrated into 1/2nd of former thick paste volume, leave standstill, filter, get crystalline deposit; Become fine powder 80 ℃ of following crushed after being dried afterwards; With Montmorillonitum, Rhizoma Rodgersiae extract and correctives, filler, in the disintegrating agent mix homogeneously, adding 75%-95% ethanol is wetting agent system soft material, granulates drying; Add again and add disintegrating agent, mix homogeneously, granulate, add fluidizer again after, tabletting makes the relieving diarrhea with astringents dispersible tablet, afterwards the packing warehouse-in.
The relieving diarrhea with astringents oral dispersion tablet preparation of the acute and chronic diarrhoea gastritis of treatment of the present invention can be used to treat adult and child's acute, chronic diarrhea, gastritis, esophagitis, colitis, gastroesophageal reflux, irritable bowel syndrome, alteration of intestinal flora; The auxiliary treatment that can also be used for the ache related symptom that stomach, esophagus, dudenal disease cause.
The relieving diarrhea with astringents oral dispersion tablet preparation of the acute and chronic diarrhoea gastritis of treatment of the present invention is canescence or off-white color, and it is fragrant and sweet to distinguish the flavor of, and wherein Cheng Ren instructions of taking is one time 3 (a 1g/ sheet), every day three times; A slice of child, every day three times, with the increase of child age, can suitably increase to one time 2.
The relieving diarrhea with astringents oral dispersion tablet preparation of the acute and chronic diarrhoea gastritis of treatment of the present invention compared with prior art has dosage and is easy to grasp, and transport easy to carryly, unilateral smooth, and taste suits, and is convenient to oral characteristics.
The specific embodiment
Embodiment 1:
Each composition proportion: Montmorillonitum 1000g, Rhizoma Rodgersiae 1660g, microcrystalline Cellulose 100g, carboxymethyl starch sodium 30g, vanillin 1.34g, aspartame 1.0g, microcrystalline silicon 3g, 85% ethanol 800ml;
Preparation method: take by weighing Rhizoma Rodgersiae 1660g, (the Rhizoma Rodgersiae extract preparation process: Rhizoma Rodgersiae is ground into coarse powder, with 80% soak with ethanol three times, soaked 48 hours for the first time, 80% ethanol consumption is 10 times of amounts of Rhizoma Rodgersiae weight to be made into extract; Respectively soaked 24 hours for the second time, for the third time, 80% ethanol consumption is 5 times of amounts of Rhizoma Rodgersiae weight; Merge soak afterwards, decompression recycling ethanol and to be concentrated into 60 ℃ of relative densities be 1.10～1.20 extractum adds hydrochloric acid and regulates pH value to 2; Standing over night afterwards filters, and it is 1.20～1.40 thick paste that filtrate decompression is concentrated into 50 ℃ of relative densities, adds 5 times of amount 80% ethanol again and makes dissolving, adds activated carbon decolorizing, filters, and filtrate is concentrated into 1/2nd of former thick paste volume, leaves standstill, filter, crystalline deposit; Become fine powder 80 ℃ of following crushed after being dried afterwards.), afterwards with vanillin 1.34g and aspartame 1.0g, mix homogeneously; Afterwards with microcrystalline Cellulose 100g, Montmorillonitum 1000g and carboxymethyl starch sodium 10g mixing, reuse 800ml 85% ethanol is made soft material as wetting agent, drying, granulate; And then add carboxymethyl starch sodium 20g mix homogeneously, and add microcrystalline silicon 3g afterwards again, mix homogeneously, tabletting makes 1000 of relieving diarrhea with astringents dispersible tablets, afterwards the packing warehouse-in.
Embodiment 2:
Each composition proportion: Montmorillonitum 1000g, Rhizoma Rodgersiae 1660g, microcrystalline Cellulose 200g, carboxymethyl starch sodium 21g, vanillin 1.34g, magnesium stearate 3.5g, 80% ethanol 850ml;
Preparation method: take by weighing Rhizoma Rodgersiae 1660g, be made into extract (the Rhizoma Rodgersiae extract preparation process is with embodiment 1), afterwards with vanillin 1.34g, mix homogeneously; Afterwards with microcrystalline Cellulose 200g, Montmorillonitum 1000g and carboxymethyl starch sodium 7g mixing, reuse 850ml 80% ethanol is made soft material as wetting agent, drying, granulate; And then add carboxymethyl starch sodium 14g mix homogeneously, and add magnesium stearate 3.5g afterwards again, mix homogeneously, tabletting makes 1000 of relieving diarrhea with astringents dispersible tablets, afterwards the packing warehouse-in.
Embodiment 3:
Each composition proportion: Montmorillonitum 1000g, Rhizoma Rodgersiae 1660g, microcrystalline Cellulose 50g, carboxymethyl starch sodium 50g, stevioside 1.3g, Pulvis Talci 2.5g, 90% ethanol 850ml;
Preparation method: take by weighing Rhizoma Rodgersiae 1660g, be made into extract (the Rhizoma Rodgersiae extract preparation process is with embodiment 1), afterwards with stevioside 1.3g, mix homogeneously; Afterwards with microcrystalline Cellulose 50g, Montmorillonitum 1000g and carboxymethyl starch sodium 20g mixing, reuse 850ml 90% ethanol is made soft material as wetting agent, drying, granulate; And then add carboxymethyl starch sodium 30g mix homogeneously, and add Pulvis Talci 2.5g afterwards again, mix homogeneously, tabletting makes 1000 of relieving diarrhea with astringents dispersible tablets, afterwards the packing warehouse-in.
Embodiment 4:
Each composition proportion: Montmorillonitum 1000g, Rhizoma Rodgersiae 1660g, starch 50g, carboxymethyl starch sodium 60g, vanillin 1.3g, aspartame 3.0g, Pulvis Talci 2g, magnesium stearate 1g, 85% ethanol 850ml;
Preparation method: take by weighing Rhizoma Rodgersiae 1660g, be made into extract (the Rhizoma Rodgersiae extract preparation process is with embodiment 1), afterwards with vanillin 1.3g, aspartame 3.0g, mix homogeneously; Afterwards with granulose 50g, Montmorillonitum 1000g and carboxymethyl starch sodium 20g mixing, reuse 850ml 85% ethanol is made soft material as wetting agent, drying, granulate; And then add carboxymethyl starch sodium 40g mix homogeneously, and add Pulvis Talci 2g afterwards again, magnesium stearate 1g, mix homogeneously, tabletting makes 1000 of relieving diarrhea with astringents dispersible tablets, afterwards the packing warehouse-in.
Embodiment 5:
Each composition proportion: Montmorillonitum 1000g, Rhizoma Rodgersiae 1660g, microcrystalline Cellulose 50g, carboxymethyl starch sodium 80g, vanillin 1.3g, stevioside 1.0g, microcrystalline silicon 1g, magnesium stearate 2g, 85% ethanol 800ml;
Preparation method: take by weighing Rhizoma Rodgersiae 1660g, be made into extract (the Rhizoma Rodgersiae extract preparation process is with embodiment 1), afterwards with vanillin 1.3g, stevioside 1.0g, mix homogeneously; Afterwards with microcrystalline Cellulose 50g, Montmorillonitum 1000g and carboxymethyl starch sodium 20g mixing, reuse 850ml 90% ethanol is made soft material as wetting agent, drying, granulate; And then add carboxymethyl starch sodium 60g mix homogeneously, and add microcrystalline silicon 1g, magnesium stearate 2g afterwards again, mix homogeneously, tabletting makes 1000 of relieving diarrhea with astringents dispersible tablets, afterwards the packing warehouse-in.
Embodiment 6:
Each composition proportion: Montmorillonitum 1000g, Rhizoma Rodgersiae 1660g, microcrystalline Cellulose 100g, cross-linking sodium carboxymethyl cellulose 30g, vanillin 1g, aspartame 1.0g, magnesium stearate 2g, 85% ethanol 850ml;
Preparation method: take by weighing Rhizoma Rodgersiae 1660g, be made into extract (the Rhizoma Rodgersiae extract preparation process is with embodiment 1), afterwards with vanillin 1g, aspartame 1.0g, mix homogeneously; Afterwards with microcrystalline Cellulose 100g, Montmorillonitum 1000g and cross-linking sodium carboxymethyl cellulose 10g, mixing, reuse 850ml 85% ethanol is made soft material as wetting agent, drying, granulate; And then add cross-linking sodium carboxymethyl cellulose 20g, and mix homogeneously adds magnesium stearate 2g afterwards again, mix homogeneously, and tabletting makes 1000 of relieving diarrhea with astringents dispersible tablets, afterwards the packing warehouse-in.
Embodiment 7:
Each composition proportion: Montmorillonitum 1000g, Rhizoma Rodgersiae 1660g, carboxymethyl starch 100g, cross-linking sodium carboxymethyl cellulose 30g, vanillin 1.34g, aspartame 1.0g, Pulvis Talci 2g, 80% ethanol 850ml;
Preparation method: take by weighing Rhizoma Rodgersiae 1660g, be made into extract (the Rhizoma Rodgersiae extract preparation process is with embodiment 1), afterwards with vanillin 1.34g, aspartame 1.0g, mix homogeneously; Afterwards with carboxymethyl starch 100g, Montmorillonitum 1000g and cross-linking sodium carboxymethyl cellulose 10g, mixing, reuse 850ml 80% ethanol is made soft material as wetting agent, drying, granulate; And then add cross-linking sodium carboxymethyl cellulose 20g, and mix homogeneously adds Pulvis Talci 2g afterwards again, mix homogeneously, and tabletting makes 1000 of relieving diarrhea with astringents dispersible tablets, afterwards the packing warehouse-in.
Embodiment 8:
Each composition proportion: Montmorillonitum 1000g, Rhizoma Rodgersiae 1660g, carboxymethyl starch 50g, microcrystalline Cellulose 50g, cross-linking sodium carboxymethyl cellulose 30g, vanillin 1.34g, stevioside 1.0g, microcrystalline silicon 2g, 90% ethanol 850ml;
Preparation method: take by weighing Rhizoma Rodgersiae 1660g, be made into extract (the Rhizoma Rodgersiae extract preparation process is with embodiment 1), afterwards with vanillin 1.34g, stevioside 1.0g, mix homogeneously; Afterwards with carboxymethyl starch 50g, microcrystalline Cellulose 50g, Montmorillonitum 1000g and cross-linking sodium carboxymethyl cellulose 10g, mixing, reuse 850ml 90% ethanol is made soft material as wetting agent, drying, granulate; And then add cross-linking sodium carboxymethyl cellulose 20g, and mix homogeneously adds microcrystalline silicon 2g afterwards again, mix homogeneously, and tabletting makes 1000 of relieving diarrhea with astringents dispersible tablets, afterwards the packing warehouse-in.
Embodiment 9:
Each composition proportion: Montmorillonitum 1000g, Rhizoma Rodgersiae 1660g, starch 50g, microcrystalline Cellulose 50g, cross-linking sodium carboxymethyl cellulose 50g, aspartame 1.0g, stevioside 1.0g, microcrystalline silicon 1g, Pulvis Talci 1g, 85% ethanol 800ml;
Preparation method: take by weighing Rhizoma Rodgersiae 1660g, be made into extract (the Rhizoma Rodgersiae extract preparation process is with embodiment 1), afterwards with aspartame 1.0g, stevioside 1.0g, mix homogeneously; Afterwards with microcrystalline Cellulose 50g, starch 50g, Montmorillonitum 1000g and cross-linking sodium carboxymethyl cellulose 20g, mixing, reuse 800ml85% ethanol is made soft material as wetting agent, drying, granulate; And then add cross-linking sodium carboxymethyl cellulose 30g, and mix homogeneously adds microcrystalline silicon 1g afterwards again, Pulvis Talci 1g, and mix homogeneously, tabletting makes 1000 of relieving diarrhea with astringents dispersible tablets, afterwards the packing warehouse-in.
Embodiment 10:
Each composition proportion: Montmorillonitum 1000g, Rhizoma Rodgersiae 1660g, starch 50g, cross-linking sodium carboxymethyl cellulose 70g, aspartame 1.0g, stevioside 1.0g, microcrystalline silicon 1g, magnesium stearate 1g, 85% ethanol 800ml;
Preparation method: take by weighing Rhizoma Rodgersiae 1660g, be made into extract (the Rhizoma Rodgersiae extract preparation process is with embodiment 1), afterwards with aspartame 1.0g, stevioside 1.0g, mix homogeneously; Afterwards with starch 50g, Montmorillonitum 1000g and cross-linking sodium carboxymethyl cellulose 20g, mixing, reuse 800ml 85% ethanol is made soft material as wetting agent, drying, granulate; And then add cross-linking sodium carboxymethyl cellulose 50g, and mix homogeneously adds microcrystalline silicon 1g afterwards again, magnesium stearate 1g, and mix homogeneously, tabletting makes 1000 of relieving diarrhea with astringents dispersible tablets, afterwards the packing warehouse-in.
Case:
Case 1: Zhang Zhi's height, man, 30 years old.People from Jining City, Shandong Province.Suffer from acute diarrhea.Clinical manifestation is the water sample stool, stomachache.Treat with compound recipe Montmorillonitum oral dispersable tablet.Oral first six, every day three times, each three.Took three days, stomachache disappears.Times of defecation is normal.
Case 2: Liu Feng, man, 22 years old.Jinan City, Shandong Province Tianqiao District people.Suffer from acute diarrhea.Clinical manifestation be mucus pus and blood shape just, stomachache, stool every day 4-6 time.Treat with compound recipe Montmorillonitum oral dispersable tablet.Oral first six, every day three times, each three.Took 5 days, the stool chemical examination is normal.
Case 3: Tian Xiaofan, man, 16 years old.The Zhifu District people of Yantai City, Shandong Province.Suffer from acute diarrhea.Clinical manifestation is rare for stool, and not molding can't be hot, and stomachache is defecated every day more than 4 times.With the treatment of compound recipe Montmorillonitum oral dispersable tablet, every day three times, each three.Took three days, times of defecation reduces, the disappearance in 5 days of suffering from diarrhoea.
Case 4: Wu Buhong, man, 30 years old.Liaocheng City people from Yanggu County, Shandong Province.Suffer from chronic diarrhea.Clinical manifestation is rare for stool, not molding and with slight stomachache, stool every day 4-6 time.Treat with compound recipe Montmorillonitum oral dispersable tablet.Every day three times, each 2.Took five days, the state of an illness heals entirely.
Case 5: Xie Hui, man, 25 years old.People from Jinxiang County of Jining City, Shandong Province.Suffer from acute gastritis.Clinical manifestation is the water sample stool, and the mucus bloody purulent stool is arranged, stomachache.Stool is treated with compound recipe Montmorillonitum oral dispersable tablet more than 5 times every day.Oral first six, every day three times, each three.Took 7 days, times of defecation reduces, and stomachache disappears, and stool routine examination is normal.
Case 6: Gao Wei, man, 6 years old.The Liangshan County people of Jining City, Shandong Province.Suffer from acute diarrhea.Clinical manifestation be egg soup sample just, stomachache can't heat, with the treatment of compound recipe Montmorillonitum oral dispersable tablet.Oral first 3, every day 3 times, each 2.After taking 48 hours, the diarrhoea number of times reduces to every day 2 times, and the stool character takes a turn for the better, and moisture obviously reduces, clinical symptom disappearance.
Case 7: Fang Hua, man, 2 years old.Jinan City, Shandong Province Huaiyin District people.Suffer from chronic diarrhea.Clinical manifestation is a water sample stool, and not molding has the heating phenomenon, times of defecation every day 4 times.Treat with compound recipe Montmorillonitum oral dispersable tablet.Oral first 1, every day 2 times, each 1.Times of defecation reduced in oral 24 hours.
Case 8: Guo Fenggao, man, 20 years old.Dezhou City people from Xiajin County, Shandong Province.Suffer from acute gastritis.Clinical manifestation is a water sample stool, stomachache, times of defecation every day about 4 times.The treatment of compound recipe Montmorillonitum oral dispersable tablet.Oral first 6, every day three times, each 3.Took 5 days, times of defecation is normal, clinical symptom disappearance.
Case 9: Yan Haitao, man, 45 years old.People from Shizhong District, Jinan City, Shandong Province.Suffer from chronic diarrhea.Clinical manifestation is the not molding of defecating, sometimes stomachache.Times of defecation every day is more than 3 times.The treatment of compound recipe Montmorillonitum oral dispersable tablet.Oral first 3, every day three times, each 3.Took 5 days, times of defecation is normal.The stool character takes a turn for the better..
Case 10: Wang Yong, man, 5 years old.Jinan City, Shandong Province Licheng District people.Suffer from chronic diarrhea.Clinical manifestation is the not molding of defecating, slight stomachache.Times of defecation is treated with compound recipe Montmorillonitum oral dispersable tablet more than 4 times every day.Oral first 3, every day 3 times, each 3.Took 4 days, times of defecation is normal.Clinical symptom disappearance.
Case 11: it is good to lift a sail, man, 18 years old.Jinan City, Shandong Province Changqing District people.Suffer from acute diarrhea.Clinical manifestation is the water sample stool, stomachache.Can't thermal phenomenon, stool every day 5-6 time, treat with compound recipe Montmorillonitum oral dispersable tablet.Oral first 6, every day 3 times, each 3.After 3 days for oral use, the stool character recovers normal, and stomachache disappears.Clinical symptom disappearance.
Claims (8)
1, a kind of relieving diarrhea with astringents oral dispersion tablet preparation and preparation method for the treatment of acute and chronic diarrhoea gastritis comprises major ingredient, adjuvant and wetting agent, it is characterized in that major ingredient comprises: Montmorillonitum and Rhizoma Rodgersiae; Adjuvant comprises filler, disintegrating agent, correctives and fluidizer; Wetting agent is: ethanol;
The weight proportion of each raw material is: 100 parts of Montmorillonitums, 166 parts of Rhizoma Rodgersiae, filler 3-20 part, disintegrating agent 1-8 part, correctives 0.1-5 part, fluidizer 0.1-0.5 part, ethanol 60-100 part.
2, the relieving diarrhea with astringents oral dispersion tablet preparation of the acute and chronic diarrhoea gastritis of treatment according to claim 1, the weight proportion that it is characterized in that each raw material is: 100 parts of Montmorillonitums, 166 parts of Rhizoma Rodgersiae, filler 4-10 part, disintegrating agent 4-7 part, correctives 1-4 part, fluidizer 0.2-0.4 part, ethanol 70-90 part.
3, the relieving diarrhea with astringents oral dispersion tablet preparation of the acute and chronic diarrhoea gastritis of treatment according to claim 1 and 2 is characterized in that the weight proportion of each raw material is: 100 parts of Montmorillonitums, 166 parts of Rhizoma Rodgersiae, 8 parts of filleies, 6 parts of disintegrating agents, 2.5 parts of correctivess, 0.3 part of fluidizer, 80 parts of ethanol.
4, according to the relieving diarrhea with astringents oral dispersion tablet preparation of claim 1 or the acute and chronic diarrhoea gastritis of 2 or 3 described treatments, it is characterized in that disintegrating agent be in disintegrating agent with add disintegrating agent, in be any one or two kinds of combinations in carboxymethyl starch sodium and the cross-linking sodium carboxymethyl cellulose with disintegrating agent; Add disintegrating agent and be any one or two kinds of combinations in carboxymethyl starch sodium and the cross-linking sodium carboxymethyl cellulose; In be 1: 1～3 with disintegrating agent and the weight ratio that adds disintegrating agent.
5, according to the relieving diarrhea with astringents oral dispersion tablet preparation of claim 1 or the acute and chronic diarrhoea gastritis of 2 or 3 described treatments, it is characterized in that filler be in microcrystalline Cellulose, carboxymethyl starch and the starch any one, two or more combination; Correctives is a kind of, two or more combination in stevioside, aspartame, the vanillin; Fluidizer is a kind of, two or more combination in microcrystalline silicon, magnesium stearate, the Pulvis Talci.
6,, it is characterized in that wetting agent ethanol is 75%-95% ethanol according to the relieving diarrhea with astringents oral dispersion tablet preparation of claim 1 or the acute and chronic diarrhoea gastritis of 2 or 3 described treatments.
7,, it is characterized in that said preparation is to disperse Formulation according to the relieving diarrhea with astringents oral dispersion tablet preparation of claim 1 or the acute and chronic diarrhoea gastritis of 2 or 3 described treatments.
8, the preparation method of the relieving diarrhea with astringents oral dispersion tablet preparation of the acute and chronic diarrhoea gastritis of the described treatment of claim 1 is characterized in that the preparation process of this dispersible tablet formulation is: it is standby to take by weighing required weight Montmorillonitum; After taking by weighing Rhizoma Rodgersiae in proportion, Rhizoma Rodgersiae is ground into coarse powder, with 80% soak with ethanol three times, soaked 48 hours for the first time, 80% ethanol consumption is 10 times of amounts of Rhizoma Rodgersiae weight; Respectively soaked 24 hours for the second time, for the third time, 80% ethanol consumption is 5 times of amounts of Rhizoma Rodgersiae weight; Merge soak afterwards, decompression recycling ethanol and concentrate in 50 ℃-60 ℃ relatively density be the extractum of 1.10-1.20, add hydrochloric acid and regulate pH value to 2; Standing over night afterwards filters, filtrate decompression concentrate in 50 ℃-60 ℃ relatively density be the thick paste of 1.20-1.40, add 5 times of amount 80% ethanol again and make dissolving, add activated carbon decolorizing, filter, filtrate is concentrated into 1/2nd of former thick paste volume, leave standstill, filter, get crystalline deposit; Become fine powder 80 ℃ of following crushed after being dried afterwards; With Montmorillonitum, Rhizoma Rodgersiae extract and correctives, filler, in the disintegrating agent mix homogeneously, adding 75%-95% ethanol is wetting agent system soft material, granulates drying; Add again and add disintegrating agent, mix homogeneously, granulate, add fluidizer again after, tabletting makes the relieving diarrhea with astringents dispersible tablet, afterwards the packing warehouse-in.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN 200610045505 CN1899330A (en) | 2006-07-17 | 2006-07-17 | Astringing and diarrhea relieving oral dispersion tablet preparation for treating acute and chronic diarrhea gastritis and preparing method |
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| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN 200610045505 CN1899330A (en) | 2006-07-17 | 2006-07-17 | Astringing and diarrhea relieving oral dispersion tablet preparation for treating acute and chronic diarrhea gastritis and preparing method |
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| CN1899330A true CN1899330A (en) | 2007-01-24 |
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Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN102389033A (en) * | 2011-09-30 | 2012-03-28 | 广东紫金正天药业有限公司 | Composition containing montmorillonite, and application of composition |
| CN103610812A (en) * | 2013-06-03 | 2014-03-05 | 陈元祥 | Chinese medicine for treating stomach illness |
-
2006
- 2006-07-17 CN CN 200610045505 patent/CN1899330A/en active Pending
Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN102389033A (en) * | 2011-09-30 | 2012-03-28 | 广东紫金正天药业有限公司 | Composition containing montmorillonite, and application of composition |
| CN103610812A (en) * | 2013-06-03 | 2014-03-05 | 陈元祥 | Chinese medicine for treating stomach illness |
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