CN1883508A - Anti-dust nasal cleanser - Google Patents
Anti-dust nasal cleanser Download PDFInfo
- Publication number
- CN1883508A CN1883508A CNA2006100811740A CN200610081174A CN1883508A CN 1883508 A CN1883508 A CN 1883508A CN A2006100811740 A CNA2006100811740 A CN A2006100811740A CN 200610081174 A CN200610081174 A CN 200610081174A CN 1883508 A CN1883508 A CN 1883508A
- Authority
- CN
- China
- Prior art keywords
- dust
- nasal
- nasal cavity
- water
- cleanser
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
Abstract
Disclosed is a nasal cavity cleaning liquid for preventing dust-in, which is prepared from the following raw materials (by weight percent): sea salt 3.0-5.0%, glycerol 0.5-1.5%, albumen candy 0.05-0.2%, water-soluble pearl powder 0.05-0.2%, lemon acid 0.05-0.2%, lemon peppermint perfume compound 0.01-0.05%, menthol 0.005-0.01%, EDTA-2Na 0.01-0.04% and balancing water.
Description
Technical field
The invention belongs to the sanitary care article technical field, relate in particular to a kind of nasal cavity and protect clean liquid with resistance dirt, fungistatic effect.
Background technology
Nasal cavity can carry out the effect of clean filtering and humidification to inhaled air.The vibrissa energy Chalk-dust filtering of nasal vestibule, the less particle dust that enters nasal cavity is subjected to action of turbulent flow, is deposited on " mucous blanket " of mucomembranous surface, borrows ciliary movement to send into pharyngeal.Contain antibody such as lysozyme, interferon and secretory IgA, sIgA in the mucous blanket, suppress and the elimination bacterial virus.Development along with commercial production and traffic, the content of airborne dust, smog increases, and nasal cavity can't carry out the detention and the clean filtering of big ratio to deleterious dust, causes a large amount of poisonous and harmful dust granules to suck the human lung, make lung tissue that pathological changes take place, have a strong impact on health.Simultaneously, the entrapment of contaminants matter of vestibule of nose increases, and the dust dirt can't in time be removed, vibrissa incrustation, and a large amount of antibacterials and virion can grow the back detention at nasal cavity or enter in the cavum nasopharyngeum at nasal cavity, become morbific one big hidden danger.How to strengthen detention dust, the clean filtering effect of nasal cavity, aseptic, the antibacterial environment of creating nasal cavity simultaneously is that nasal cavity protects the direction that clean articles for use are studied from now on.
Existing nasal nursing with medicine or articles for use all at the sterilization problem of nasal cavity, adopt antibiotic medicines such as medicine such as effective germ killing drugs such as Radix Isatidis extract, metronidazole, Folium Isatidis or aspirin, ibuprofen, chlorphenamine, be mixed with into nasal cavity with wetting agent and aqueous solvent etc. and clean the medicine articles for use.Though this nasal cavity cleanout fluid can effectively be killed most harmful pathogenic bacterias, nasal cavity is played the effect of virus killing sterilization, but it has been ignored and has had the physiology path between nasal cavity and cranial cavity, and the ingredient that the nasal cavity mucosa absorbs can be very fast enters the human body brain, and then brain is brought harmful effect.Therefore use medicine and antibiotic medicine that nasal cavity is cleaned or sterilization can increase side effect and hazards of medication degree to human body.Existing nasal cavity has been ignored the hazardness of the excessive suction of harmful dust to the human lung with health product simultaneously, does not consider that the nasal nursing articles for use should have the effect of filtration resistance dirt.
Show through human experimentation and application practice, the nasal cavity that contains antibiotic or other medicines composition protects clean liquid and can bring other diseases such as nasal cavity inflammation when often using, its main cause is that medicine is too strong to the zest of bronchia mucosal, and secular drug effect has destroyed due to the physiological equilibrium of nasal cavity.
Summary of the invention
The purpose of this invention is to provide a kind of have remarkable resistance dirt and nasal cavity fungistatic effect, and human body and nasal cavity nasal cavity without any side effects are protected clean articles for use, solved the without hindrance dirt effect of existing nasal nursing health product, the problem bigger the human body side effect.
The technical solution used in the present invention is as follows:
A kind of anti-dust nasal cleanser is characterized in that it comprises that following raw materials by weight percent is formulated:
Sea salt 3.0～5.0% glycerol 0.5～1.5%
Protein sugar 0.05～0.2% water soluble Margarita ultrafine powder 0.05～0.2%
Citric acid 0.05～0.2% balm-mint Melissa officinali essence 0.01～0.05%
Mentholum 0.005～0.01% EDTA-2Na 0.01～0.04%
Water surplus
This anti-dust nasal cleanser is formulated by following raw materials by weight percent:
Sea salt 3.0～5.0% glycerol 0.5～1.5%
Protein sugar 0.05～0.2% water soluble Margarita ultrafine powder 0.05～0.2%
Lemon yellow 0.002～0.006% potassium sorbate 0.05～0.15%
Citric acid 0.05～0.2% balm-mint Melissa officinali essence 0.01～0.05%
Mentholum 0.005～0.01% Oleum menthae 0.002～0.008%
Color stabilizer 0.01～0.05% EDTA-2Na 0.01～0.04%
Water surplus
This anti-dust nasal cleanser is formulated by following concrete raw materials by weight percent:
Sea salt 4.0% glycerol 1.0%
Protein sugar 0.10% water soluble Margarita ultrafine powder 0.10%
Lemon yellow 0.004% potassium sorbate 0.12%
Citric acid 0.10% balm-mint Melissa officinali essence 0.025%
Mentholum 0.0075% Oleum menthae 0.005%
Color stabilizer 0.03% EDTA-2Na 0.02%
Water surplus
Described wet concentration is with newly drawing water.
Described balm-mint Melissa officinali essence can replace with pure and fresh floral perfume.
Described glycerol can replace with hyaluronic acid.
Each concentration of component of this anti-dust nasal cleanser is lower, and bronchia mucosal is not had any stimulation.Selected water can be distilled water, well water or spring water, preferably selects for use newly to draw water.Newly drawing water is meant the well water of just being up to early morning, essentials of Matea Medica record when no " at the beginning of go out to say newly draw water ", on each medical ancient books and records of China all record newly draw water and have medical value.Glycerol or hyaluronic acid contain the moist composition of preserving moisture, and can keep nasal cavity moistening comfortable as wetting agent.Water soluble Margarita ultrafine powder can increase the nutritional labeling of nasal cavity probiotics growth.Citric acid not only has excellent cleaning effect as cleaning material, also nasal cavity is not had any stimulation.Mentholum and Oleum menthae both can be used as transdermal enhancer, can play again to increase cold, the cephalocathartic effect of refreshing oneself, and increased and used the comfort of protecting clean liquid.EDTA-2Na (disodium EDTA) can effectively regulate the acid or alkali environment of nasal cavity as the pH value regulator, suppresses the growth of noxious bacteria.
Anti-dust nasal cleanser provided by the invention does not contain sensitizer, and each contained set of dispense does not have any stimulation than very little to nasal mucosa, and contains nutritious and the composition of preserving moisture.During use, this an amount of nasal cavity is protected clean liquid spray into nasal cavity and get final product.The results showed that this anti-dust nasal cleanser has strong inhibitory action to escherichia coli, staphylococcus aureus, Staphylococcus albus, the Klebsiella Pneumoniae of anti-cephalo-type the, pseudomonas aeruginosa, Salmonella, it is remarkable to hinder the dirt effect simultaneously.This anti-dust nasal cleanser can effectively stop the dust of suction, eliminates the pathogenic influence of harmful dust to pulmonary, can suppress the noxious bacteria procreation of nasal cavity simultaneously, keeps the hygiene and health of nasal cavity.This anti-dust nasal cleanser can be used for the nasal cavity cleaning nursing of work crowd under the individual nasal cavity cleaning nursing, the particularly environment that the workman of many dust mining industry, traffic-police and inspirable particle concentration are high.
The specific embodiment
The invention will be further elaborated with experiment below in conjunction with embodiment.
Embodiment 1 presses column weight amount proportioning and gets raw material:
Sea salt 16kg glycerol 4.0kg
Protein sugar 0.4kg water soluble Margarita ultrafine powder 0.4kg
Lemon yellow 0.016kg potassium sorbate 0.48kg
Citric acid 0.4kg balm-mint Melissa officinali essence 0.1kg
Mentholum 0.03kg Oleum menthae 0.02kg
Color stabilizer 0.12kg EDTA-2Na 0.08kg
378kg newly draws water
Above-mentioned raw materials is the commercial goods, and wherein sea salt is selected the sea salt that Tianjin Changlu Hangu Salt Field produces for use; Glycerol is the edible glycerol that Guangdong Ao Sibao sweetening treatment company produces; The chemical name of protein sugar is α-L-aspartoyl-L phenyalanine methyl ester, for the Lang Shi of Shenzhen industrial corporation produces; Water soluble Margarita ultrafine powder produces for Taizhou, Zhejiang; Lemon yellow is that Shanghai Xin Le industrial corporation produces; Potassium sorbate is the auspicious general biochemical corp manufacturing in Shandong; Citric acid is that Weifang, Shandong company of Huiyuan produces citric acid monohydrate; Balm-mint Melissa officinali essence, Mentholum and Oleum menthae are Man essence and flavoring agent company and make; EDTA-2Na is that the Beijing Chemical Plant makes.
Above-mentioned each raw material dropped into successively newly draw water, mix, the orange-yellow transparency liquid that obtains is anti-dust nasal cleanser.
The anti-dust nasal cleanser that Application Example 1 is equipped with send Chinese medicine science medicine per os toxicity test that plant research carries out, and selects for use 100 of ICR mices as laboratory animal, and body weight is at 18～22g, male and female half and half.Mice is divided into five groups, and 20 every group, male and female half and half are tested fasting in preceding 6 hours, once irritate stomach 0.4ml/20g, and dosage is 20g/kg, 10g/kg, and 5g/kg, 2.5g/kg, 1.25g/kg observes the animal poisoning manifestations every day, continuous 14 days.After the administration, each treated animal does not have death, does not have any untoward reaction yet.This shows that institute's laboratory sample metering is not seen any untoward reaction much larger than 5g/kg the time, according to " disinfection technology standard ", this composition nasal cavity protects clean liquid sample and belongs to actual nontoxic level.
Embodiment 2 presses column weight amount proportioning and gets raw material:
Sea salt 12kg glycerol 6.0kg
Protein sugar 0.2kg water soluble Margarita ultrafine powder 0.8kg
The pure and fresh floral perfume 0.04kg of citric acid 0.2kg
Mentholum 0.02kg EDTA-2Na 0.16kg
Mineral water 380.6kg
Pure and fresh floral perfume is that Man essence and flavoring agent company makes in the above-mentioned raw materials, and above-mentioned each raw material is dropped in the mineral water, mixes then and mixes through homogenizer, obtains colourless transparent liquid.
The anti-dust nasal cleanser that embodiment 2 systems are joined carries out the active detection test of external bacteriostasis, and experimental technique adopts tube dilution method and micro-dilution method, respectively referring to " disinfection technology standard " (version in 2002; P85-86) and " pharmacological experimental methodology " (third edition; The Xu Shuyun chief editor; P1658-1659).Experimental strain is escherichia coli (Escherichia.coli) 8099, staphylococcus aureus (Staphylococcus aureus) ATCC 6538, Staphylococcus albus (Staphylococcus albus) 8032 bacterial strains, escherichia coli (Escherichia.coli) ATCC 25922 bacterial strains, staphylococcus aureus (Staphylococcus aureus) ATCC 25923, ATCC 29213, the Klebsiella Pneumoniae of anti-cephalo-type the (Klebsiella pneumoniae) ATCC 700603, pseudomonas aeruginosa (Pseudomonas aeruginosa) ATCC 27853, Salmonella (Salmonella enteritidis) DMS 4224.Experimental result sees Table 1.
Table 1 anti-dust nasal cleanser is to the MCI (former protect clean liquid concentration be 1) of test bacterium
| Protect clean liquid concentration | ||||
| Bacterial strain | 1/2 | 1/4 | 1/8 | 1/16 |
| Escherichia coli 8099 | - | + | + | + |
| Escherichia coli 25922 | - | + | + | + |
| Staphylococcus aureus 6538 | - | - | + | + |
| Staphylococcus aureus 25923 | - | - | - | + |
| Staphylococcus aureus 29213 | - | + | + | + |
| Staphylococcus albus 8032 | - | - | - | + |
| Klebsiella Pneumoniae 700603 | - | + | + | + |
| Pseudomonas aeruginosa 27853 | - | + | + | + |
| Salmonella DMS 4224 | - | + | + | + |
| Negative CK | - | - | - | - |
| Positive CK | + | + | + | + |
Annotate: "-" expression asepsis growth, "+" expression has bacteria growing.
Last harmony in the exterior micromethod result of the test shows, this anti-dust nasal cleanser is inhibited to escherichia coli, staphylococcus aureus, Staphylococcus albus, Klebsiella Pneumoniae, pseudomonas aeruginosa and Salmonella, and is wherein the strongest to the staphylococcus aureus inhibitory action.
Embodiment 3 presses column weight amount proportioning and gets raw material:
Sea salt 20kg hyaluronic acid 2.0kg
Protein sugar 0.8kg water soluble Margarita ultrafine powder 0.2kg
Lemon yellow 0.024kg potassium sorbate 0.2kg
Citric acid 0.8kg balm-mint Melissa officinali essence 0.04kg
Mentholum 0.04kg Oleum menthae 0.008kg
Color stabilizer 0.2kg EDTA-2Na 0.04kg
380.6kg newly draws water
Above-mentioned raw materials is mixed, and high-speed stirred, obtain light yellow transparent liquid and be the anti-dust nasal cleanser finished product.
The anti-dust nasal cleanser that adopts embodiment 3 systems to join carries out the quantitative bacteriostatic test of suspension, and test basis is " disposable use hygienic article sanitary standard " GB15979-2002.The bacteriostatic test condition: test temperature is 20-21 ℃ water-bath, the test triplicate, and test organisms is selected the 11st cash equivalent Staphylococcus aureus ATCC6538 for use, and result of the test sees Table 2.
The quantitative bacteriostatic experiment result of the suspension of table 2 anti-dust nasal cleanser
| Nasal cavity protects clean liquid experimental concentration, % | The average kill ratio and the scope of effect different time, % | |||
| 2min | 5min | 10min | 20min | |
| 100 | 100.00 (100.00-100.00) | 100.00 (100.00-100.00) | 100.00 (100.00-100.00) | 100.00 (100.00-100.00) |
Annotate: the average clump count of positive controls is 7.80 * 10
4Cfu/ml, the equal asepsis growth of negative control group.
Experimental result shows, under 20-21 ℃ of water bath condition, anti-dust nasal cleanser stock solution effect 2min is 100% to the average bacteriostasis rate of staphylococcus aureus.
Embodiment 4 presses column weight amount proportioning and gets raw material:
Sea salt 12kg glycerol 2.0kg
Protein sugar 0.2kg water soluble Margarita ultrafine powder 0.2kg
Lemon yellow 0.008kg potassium sorbate 0.2kg
The pure and fresh floral perfume 0.04kg of citric acid 0.2kg
Mentholum 0.02kg Oleum menthae 0.008kg
Color stabilizer 0.04kg EDTA-2Na 0.04kg
Distilled water 385kg
Above-mentioned each raw material is dropped in the distilled water successively, mix fast, obtain anti-dust nasal cleanser, this anti-dust nasal cleanser is a light yellow transparent liquid.
The anti-dust nasal cleanser of Application Example 4 preparations hinders dirt experiment on probation to the dust atmosphere operating worker.Experimental technique is as follows:
1. labourer's proof test
Select to have in the air four working spaces of opening Fan Ge village branch company of Luan cleaned coal limited company of quantitative dust concentration, promptly combine and adopt a team, combine and adopt three teams, combine the labourer that adopts four teams and tunnel two teams as experimental subject; Choose same working space, close labor intensity, age between 20～50 years old, do not have totally 120 of the labourers of obvious respiratory tract disease (as flu, sinusitis, rhinorrhea), divide two groups, one is 60 of matched groups, one is 60 of experimental grouies.Matched group does not use before putting into production and protects clean liquid, the nasal cavity cleaning after 2 hours of working; Experimental group protects clean liquid in the forward direction nasal cavity spray of putting into production, works and uses same nasal cavity cleaning after 1 hour, and the 2 hours same again nasal cavity cleaning of working compare the dust weight in the nasal cavity cleaning liquid.
The experimenter fills in the experiment list, uses this to protect the comfort level behind the clean liquid and the investigation of satisfaction simultaneously.
2. the mensuration of on-the-spot air-borne dust concentration and on-the-spot air-borne dust dispersion is measured according to " dust determination method in the air of workplace " (GB5748-85).
Test on-the-spot airborne dust concentration measurement result and see Table 3, the respiratory concentration determination the results are shown in Table 4.
The total dust concentration measurement result that each experiment of table 3 is on-the-spot
| Group | Combine and adopt a team | Combine and adopt three teams | Combine and adopt four teams | Tunnel two teams |
| Total dust concentration scope (mg/m 3) | 2.6-13.2 | 28.9-42.3 | 2.2-68.4 | 12.2-219.2 |
The respirable dust concentration measurement result that each experiment of table 4 is on-the-spot
| Group | Combine and adopt a team | Combine and adopt three teams | Combine and adopt four teams | Tunnel two teams |
| Respirable dust concentration (mg/m 3) | 1.4-8.0 | 18.7-31.9 | 1.3-30.0 | 4.9-130.0 |
Test on-the-spot airborne dust dispersity measurement result and see Table 5.
The dust dispersity measurement result that each experiment of table 5 is on-the-spot
| Group | ＜2μ(％) | 2μ-5μ(％) | 5μ-10μ(％) | ＞10μ(％) |
| Combine and adopt a team | 7-30 | 37-80 | 9-33 | 1-16 |
| Combine and adopt three teams | 14-34 | 42-78 | 3-36 | 1-4 |
| Combine and adopt four teams | 0-33 | 31-86 | 10-45 | 0-27 |
| Tunnel two teams | 2-48 | 38-75 | 2-38 | 0-17 |
The dust weighing result relatively sees Table 6 in experimenter's nasal cavity eluate, its statistical result analysis in table 7.Its empty group is the Dust Capacity in the nasal cavity eluate of experimenter before putting into production.
Table 6 is respectively organized experimenter's nasal cavity and is washed out the Dust Capacity statistical table
| Group | The blank Dust Capacity (mg) of experimental group | Experimental group Dust Capacity (mg) | Matched group Dust Capacity (mg) |
| Combine and adopt a team | 0.35-59.77 | 17.27-381.01 | 1.93-164.80 |
| Combine and adopt three teams | 1.25-31.72 | 40.56-362.78 | 23.90-105.43 |
| Combine and adopt four teams | 4.42-63.69 | 65.93-232.35 | 5.03-100.04 |
| Tunnel two teams | 1.37-37.69 | 75.20-203.19 | 1.32-110.17 |
Table 7 is respectively organized experimenter's nasal cavity and is washed out the Dust Capacity analysis result
| Group | The experimental group blank | Experimental group | Matched group | T # | P # | |||
| Average | Standard deviation | Average | Standard deviation | Average | Standard deviation | |||
| Combine and adopt a team | 22.61 | 14.36 | 102.89 | 84.52 | 43.06 | 39.71 | 5.89 | ＜0.05 |
| Combine and adopt three teams | 12.72 | 10.04 | 198.45 | 97.11 | 75.23 | 26.78 | 8.65 | ＜0.05 |
| Combine and adopt four teams | 29.60 | 16.56 | 133.43 | 49.67 | 38.56 | 24.95 | 13.27 | ＜0.05 |
| Tunnel two teams | 21.40 | 9.86 | 141.10 | 38.52 | 57.29 | 25.97 | 5.06 | ＜0.05 |
By table 6 and table 7 as can be seen, experimental group is compared with matched group has significant difference, and this anti-dust nasal cleanser has significant resistance dirt effect.
The dispersion that dry matter analysis in the experimental group nasal cavity eluate is obtained nasal cavity detention dust the results are shown in Table 8.
The measurement result of the dust dispersity in the table 8 experimental group nasal cavity eluate
Investigate as can be known by the use to experimental group experimenter 60 people, use comfortable person 49 people of this anti-dust nasal cleanser aftersensation, account for 81.7%, general person 11 people account for 18.3%, untoward reaction person 0 people.It is wider to this shows that this anti-dust nasal cleanser is suitable for crowd's scope.
Embodiment 5 presses column weight amount proportioning and gets raw material:
Sea salt 20kg hyaluronic acid 6.0kg
Protein sugar 0.8kg water soluble Margarita ultrafine powder 0.8kg
Potassium sorbate 0.6kg EDTA-2Na 0.16kg
Citric acid 0.8kg balm-mint Melissa officinali essence 0.2kg
Mentholum 0.04kg Oleum menthae 0.032kg
370.5kg newly draws water
With fully mixing through homogenizer after above-mentioned each raw material mixing, obtain the anti-dust nasal cleanser of water white transparency shape.Show that through experiment on probation this anti-dust nasal cleanser has significant resistance dirt effect and good bacteriostasis.
Claims (6)
1. anti-dust nasal cleanser is characterized in that it comprises that following raw materials by weight percent is formulated:
Sea salt 3.0～5.0% glycerol 0.5～1.5%
Protein sugar 0.05～0.2% water soluble Margarita ultrafine powder 0.05～0.2%
Citric acid 0.05～0.2% balm-mint Melissa officinali essence 0.01～0.05%
Mentholum 0.005～0.01% EDTA-2Na 0.01～0.04%
Water surplus.
2. anti-dust nasal cleanser according to claim 1 is characterized in that it is formulated by following raw materials by weight percent:
Sea salt 3.0～5.0% glycerol 0.5～1.5%
Protein sugar 0.05～0.2% water soluble Margarita ultrafine powder 0.05～0.2%
Lemon yellow 0.002～0.006% potassium sorbate 0.05～0.15%
Citric acid 0.05～0.2% balm-mint Melissa officinali essence 0.01～0.05%
Mentholum 0.005～0.01% Oleum menthae 0.002～0.008%
Color stabilizer 0.01～0.05% EDTA-2Na 0.01～0.04%
Water surplus.
3. anti-dust nasal cleanser according to claim 1 is characterized in that it is formulated by following raw materials by weight percent:
Sea salt 4.0% glycerol 1.0%
Protein sugar 0.10% water soluble Margarita ultrafine powder 0.10%
Lemon yellow 0.004% potassium sorbate 0.12%
Citric acid 0.10% balm-mint Melissa officinali essence 0.025%
Mentholum 0.0075% Oleum menthae 0.005%
Color stabilizer 0.03% EDTA-2Na 0.02%
Water surplus.
4. according to claim 1,2 or 3 described anti-dust nasal cleansers, it is characterized in that described wet concentration is with newly drawing water.
5. according to claim 1,2 or 3 described anti-dust nasal cleansers, it is characterized in that described balm-mint Melissa officinali essence can replace with pure and fresh floral perfume.
6. according to claim 1,2 or 3 described anti-dust nasal cleansers, it is characterized in that described glycerol can replace with hyaluronic acid.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CNB2006100811740A CN100425246C (en) | 2006-05-24 | 2006-05-24 | Anti-dust nasal cleanser |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CNB2006100811740A CN100425246C (en) | 2006-05-24 | 2006-05-24 | Anti-dust nasal cleanser |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| CN1883508A true CN1883508A (en) | 2006-12-27 |
| CN100425246C CN100425246C (en) | 2008-10-15 |
Family
ID=37581890
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CNB2006100811740A Expired - Fee Related CN100425246C (en) | 2006-05-24 | 2006-05-24 | Anti-dust nasal cleanser |
Country Status (1)
| Country | Link |
|---|---|
| CN (1) | CN100425246C (en) |
Cited By (10)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2008123471A1 (en) * | 2007-03-30 | 2008-10-16 | Kobayashi Pharmaceutical Co., Ltd. | Composition for cleaning nasal fossa |
| JP2008247821A (en) * | 2007-03-30 | 2008-10-16 | Kobayashi Pharmaceut Co Ltd | External application composition |
| CN102204926A (en) * | 2011-05-31 | 2011-10-05 | 江苏富林医疗设备有限公司 | Nasal cavity cleaning agent |
| CN102764269A (en) * | 2012-08-15 | 2012-11-07 | 天津市星河系科技有限公司 | Nasal cavity health care cleansing solution and preparation method thereof |
| CN103096908A (en) * | 2010-09-07 | 2013-05-08 | 可利威玛瑟巴施有限公司 | Nasal spray |
| US20130156871A1 (en) * | 2011-12-20 | 2013-06-20 | Water Pik, Inc. | Nasal Wash Solution |
| CN103385901A (en) * | 2012-05-07 | 2013-11-13 | 胡维民 | Powder directly used in nasal washing |
| ES2457724A1 (en) * | 2012-10-27 | 2014-04-28 | Jose HERNANDEZ MONDEJAR | Physiological solution for rectal hygiene (Machine-translation by Google Translate, not legally binding) |
| ES2458740A1 (en) * | 2012-11-02 | 2014-05-06 | Jose HERNANDEZ MONDEJAR | Use of physiological solution for internal anal canal hygiene (Machine-translation by Google Translate, not legally binding) |
| CN104721490A (en) * | 2015-04-02 | 2015-06-24 | 环境保护部南京环境科学研究所 | Nasal spray for efficiently filtering and preventing air pollutants and preparation method thereof |
Family Cites Families (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1358098A (en) * | 1999-06-30 | 2002-07-10 | 斯科特·科德雷 | Nasal spray having dead sea salts |
| CN1289085C (en) * | 2002-04-26 | 2006-12-13 | 中国人民解放军军事医学科学院毒物药物研究所 | Nasal spray agent |
-
2006
- 2006-05-24 CN CNB2006100811740A patent/CN100425246C/en not_active Expired - Fee Related
Cited By (11)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2008123471A1 (en) * | 2007-03-30 | 2008-10-16 | Kobayashi Pharmaceutical Co., Ltd. | Composition for cleaning nasal fossa |
| JP2008247821A (en) * | 2007-03-30 | 2008-10-16 | Kobayashi Pharmaceut Co Ltd | External application composition |
| CN103096908A (en) * | 2010-09-07 | 2013-05-08 | 可利威玛瑟巴施有限公司 | Nasal spray |
| CN103096908B (en) * | 2010-09-07 | 2017-03-15 | 可利威玛瑟巴施有限公司 | Nasal spray |
| CN102204926A (en) * | 2011-05-31 | 2011-10-05 | 江苏富林医疗设备有限公司 | Nasal cavity cleaning agent |
| US20130156871A1 (en) * | 2011-12-20 | 2013-06-20 | Water Pik, Inc. | Nasal Wash Solution |
| CN103385901A (en) * | 2012-05-07 | 2013-11-13 | 胡维民 | Powder directly used in nasal washing |
| CN102764269A (en) * | 2012-08-15 | 2012-11-07 | 天津市星河系科技有限公司 | Nasal cavity health care cleansing solution and preparation method thereof |
| ES2457724A1 (en) * | 2012-10-27 | 2014-04-28 | Jose HERNANDEZ MONDEJAR | Physiological solution for rectal hygiene (Machine-translation by Google Translate, not legally binding) |
| ES2458740A1 (en) * | 2012-11-02 | 2014-05-06 | Jose HERNANDEZ MONDEJAR | Use of physiological solution for internal anal canal hygiene (Machine-translation by Google Translate, not legally binding) |
| CN104721490A (en) * | 2015-04-02 | 2015-06-24 | 环境保护部南京环境科学研究所 | Nasal spray for efficiently filtering and preventing air pollutants and preparation method thereof |
Also Published As
| Publication number | Publication date |
|---|---|
| CN100425246C (en) | 2008-10-15 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| CN1883508A (en) | Anti-dust nasal cleanser | |
| RU2536264C2 (en) | Topical dermal composition containing salt and sugar as active ingredients for preventing and treating vaginosis, and using it | |
| KR20180030970A (en) | Formulation for treatment of mouth, throat and respiratory tract diseases | |
| CN106309401A (en) | Bathing effervescent tablets for preventing and treating skin diseases | |
| CN101496811A (en) | Soluble and stable tilmicosin composition | |
| CN1943675A (en) | Tibetan medicinal composition for expectorant, antitussive, antiasthmatic and its preparation method | |
| JP2926145B2 (en) | Anti-disease feed and feed additives for cattle and pigs | |
| CN113995744A (en) | Composition and antibacterial application thereof | |
| CN113273646A (en) | Powder for sow parturition and inoculation as well as preparation method and application thereof | |
| CN103070813A (en) | Toothpaste applicable to chronic sinusitis patients | |
| CN102525948A (en) | Dry suspension of cefpodoxime proxetil composition and preparation method thereof | |
| CN1238054C (en) | Biotechnological formulation for suppressing and killing helicobacter pylori, its preparation and use | |
| TWI656872B (en) | Antiviral effects of narasin in swine feed | |
| CN100335126C (en) | Preparation for preventing and curing endometritis for dairy cattle and preparing method thereof | |
| RU2461385C1 (en) | Method of preventing respiratory diseases in calves | |
| CN112294789B (en) | Compound preparation for preventing and treating respiratory tract infection and application thereof | |
| CN107970272A (en) | The purposes of pithecellobium clypearia or extract in treatment and/or the bronchopneumonic medicine of auxiliary treatment livestock and poultry is prepared | |
| CN101797374A (en) | Compound minocycline hydrochloride soluble powder for treating respiratory diseases of poultry | |
| CN108056930A (en) | A kind of children's toothpaste and its preparation process | |
| Kusumawardani et al. | The effect of ethanolic extract of propolis on skin manifestation and skin tissue necrosis in cutaneous anthrax animal model | |
| CN114053331A (en) | Oral cavity antibacterial composition, oral cavity antibacterial liquid, application and preparation method | |
| CN104815095A (en) | Composition with vaginal microecological balance repairing and recovering functions | |
| CN105213360B (en) | Application of the citric acid iodine in the medicine for preparing treatment livestock and poultry disease of digestive system | |
| CN103933085B (en) | The application of Herba Andrographitis and phosphonomycin in the compound medicine for preparing treatment livestock and poultry coli-infection disease | |
| CN102397330B (en) | Compound oil-in-water schizonepeta spike oil nanoemulsion composition and preparation method thereof |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| C06 | Publication | ||
| PB01 | Publication | ||
| C10 | Entry into substantive examination | ||
| SE01 | Entry into force of request for substantive examination | ||
| C14 | Grant of patent or utility model | ||
| GR01 | Patent grant | ||
| CF01 | Termination of patent right due to non-payment of annual fee |
Granted publication date: 20081015 Termination date: 20150524 |
|
| EXPY | Termination of patent right or utility model |