CN1882352B - 用于治疗多发性硬化的包含透明质酸锌复合物的药物组合物 - Google Patents
用于治疗多发性硬化的包含透明质酸锌复合物的药物组合物 Download PDFInfo
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- 239000000843 powder Substances 0.000 description 1
- 238000004321 preservation Methods 0.000 description 1
- 125000002924 primary amino group Chemical group [H]N([H])* 0.000 description 1
- 230000000750 progressive effect Effects 0.000 description 1
- 230000001681 protective effect Effects 0.000 description 1
- 229940038850 rebif Drugs 0.000 description 1
- 108020003175 receptors Proteins 0.000 description 1
- 102000005962 receptors Human genes 0.000 description 1
- 230000007115 recruitment Effects 0.000 description 1
- 238000000518 rheometry Methods 0.000 description 1
- 206010039073 rheumatoid arthritis Diseases 0.000 description 1
- 210000000582 semen Anatomy 0.000 description 1
- 230000035807 sensation Effects 0.000 description 1
- 210000003491 skin Anatomy 0.000 description 1
- 239000011734 sodium Substances 0.000 description 1
- 229910052708 sodium Inorganic materials 0.000 description 1
- 239000001632 sodium acetate Substances 0.000 description 1
- 235000017281 sodium acetate Nutrition 0.000 description 1
- 235000017557 sodium bicarbonate Nutrition 0.000 description 1
- 229910000030 sodium bicarbonate Inorganic materials 0.000 description 1
- WBHQBSYUUJJSRZ-UHFFFAOYSA-M sodium bisulfate Chemical compound [Na+].OS([O-])(=O)=O WBHQBSYUUJJSRZ-UHFFFAOYSA-M 0.000 description 1
- 229910000342 sodium bisulfate Inorganic materials 0.000 description 1
- 229940100996 sodium bisulfate Drugs 0.000 description 1
- 229910000029 sodium carbonate Inorganic materials 0.000 description 1
- 235000017550 sodium carbonate Nutrition 0.000 description 1
- 229910001415 sodium ion Inorganic materials 0.000 description 1
- 239000001488 sodium phosphate Substances 0.000 description 1
- 229910000162 sodium phosphate Inorganic materials 0.000 description 1
- 235000011008 sodium phosphates Nutrition 0.000 description 1
- 229940001482 sodium sulfite Drugs 0.000 description 1
- 235000010265 sodium sulphite Nutrition 0.000 description 1
- 235000010339 sodium tetraborate Nutrition 0.000 description 1
- AKHNMLFCWUSKQB-UHFFFAOYSA-L sodium thiosulfate Chemical compound [Na+].[Na+].[O-]S([O-])(=O)=S AKHNMLFCWUSKQB-UHFFFAOYSA-L 0.000 description 1
- 229940001474 sodium thiosulfate Drugs 0.000 description 1
- 235000019345 sodium thiosulphate Nutrition 0.000 description 1
- YWIVKILSMZOHHF-QJZPQSOGSA-N sodium;(2s,3s,4s,5r,6r)-6-[(2s,3r,4r,5s,6r)-3-acetamido-2-[(2s,3s,4r,5r,6r)-6-[(2r,3r,4r,5s,6r)-3-acetamido-2,5-dihydroxy-6-(hydroxymethyl)oxan-4-yl]oxy-2-carboxy-4,5-dihydroxyoxan-3-yl]oxy-5-hydroxy-6-(hydroxymethyl)oxan-4-yl]oxy-3,4,5-trihydroxyoxane-2- Chemical class [Na+].CC(=O)N[C@H]1[C@H](O)O[C@H](CO)[C@@H](O)[C@@H]1O[C@H]1[C@H](O)[C@@H](O)[C@H](O[C@H]2[C@@H]([C@@H](O[C@H]3[C@@H]([C@@H](O)[C@H](O)[C@H](O3)C(O)=O)O)[C@H](O)[C@@H](CO)O2)NC(C)=O)[C@@H](C(O)=O)O1 YWIVKILSMZOHHF-QJZPQSOGSA-N 0.000 description 1
- 239000008107 starch Substances 0.000 description 1
- 235000019698 starch Nutrition 0.000 description 1
- 210000002784 stomach Anatomy 0.000 description 1
- 238000010254 subcutaneous injection Methods 0.000 description 1
- 239000007929 subcutaneous injection Substances 0.000 description 1
- 239000005720 sucrose Substances 0.000 description 1
- 235000000346 sugar Nutrition 0.000 description 1
- 239000000829 suppository Substances 0.000 description 1
- 239000000375 suspending agent Substances 0.000 description 1
- 239000006188 syrup Substances 0.000 description 1
- 235000020357 syrup Nutrition 0.000 description 1
- RCINICONZNJXQF-MZXODVADSA-N taxol Chemical compound O([C@@H]1[C@@]2(C[C@@H](C(C)=C(C2(C)C)[C@H](C([C@]2(C)[C@@H](O)C[C@H]3OC[C@]3([C@H]21)OC(C)=O)=O)OC(=O)C)OC(=O)[C@H](O)[C@@H](NC(=O)C=1C=CC=CC=1)C=1C=CC=CC=1)O)C(=O)C1=CC=CC=C1 RCINICONZNJXQF-MZXODVADSA-N 0.000 description 1
- RTKIYNMVFMVABJ-UHFFFAOYSA-L thimerosal Chemical compound [Na+].CC[Hg]SC1=CC=CC=C1C([O-])=O RTKIYNMVFMVABJ-UHFFFAOYSA-L 0.000 description 1
- 229940033663 thimerosal Drugs 0.000 description 1
- 208000037816 tissue injury Diseases 0.000 description 1
- 239000000196 tragacanth Substances 0.000 description 1
- 235000010487 tragacanth Nutrition 0.000 description 1
- 229940116362 tragacanth Drugs 0.000 description 1
- 108091005703 transmembrane proteins Proteins 0.000 description 1
- 102000035160 transmembrane proteins Human genes 0.000 description 1
- BSVBQGMMJUBVOD-UHFFFAOYSA-N trisodium borate Chemical compound [Na+].[Na+].[Na+].[O-]B([O-])[O-] BSVBQGMMJUBVOD-UHFFFAOYSA-N 0.000 description 1
- RYFMWSXOAZQYPI-UHFFFAOYSA-K trisodium phosphate Chemical compound [Na+].[Na+].[Na+].[O-]P([O-])([O-])=O RYFMWSXOAZQYPI-UHFFFAOYSA-K 0.000 description 1
- 230000009385 viral infection Effects 0.000 description 1
- 210000004127 vitreous body Anatomy 0.000 description 1
- 230000029663 wound healing Effects 0.000 description 1
- 235000005074 zinc chloride Nutrition 0.000 description 1
- 239000011592 zinc chloride Substances 0.000 description 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
- A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/70—Carbohydrates; Sugars; Derivatives thereof
- A61K31/715—Polysaccharides, i.e. having more than five saccharide radicals attached to each other by glycosidic linkages; Derivatives thereof, e.g. ethers, esters
- A61K31/726—Glycosaminoglycans, i.e. mucopolysaccharides
- A61K31/728—Hyaluronic acid
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K33/00—Medicinal preparations containing inorganic active ingredients
- A61K33/24—Heavy metals; Compounds thereof
- A61K33/30—Zinc; Compounds thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
- Y02A50/00—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
- Y02A50/30—Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Medicinal Chemistry (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Chemical & Material Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Epidemiology (AREA)
- Neurosurgery (AREA)
- Neurology (AREA)
- Biomedical Technology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Organic Chemistry (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Dermatology (AREA)
- Inorganic Chemistry (AREA)
- Molecular Biology (AREA)
- Psychiatry (AREA)
- Psychology (AREA)
- Hospice & Palliative Care (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicinal Preparation (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| HUP0303779 | 2003-11-20 | ||
| HU0303779A HUP0303779A2 (en) | 2003-11-20 | 2003-11-20 | Pharmaceutical compositions containing hyaluronan complex for the treatment of sclerosis multiplex |
| PCT/HU2004/000107 WO2005049047A1 (en) | 2003-11-20 | 2004-11-18 | Pharmaceutical composition comprising a zinc-hyaluronate complex for the treatment of multiple sclerosis |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| CN1882352A CN1882352A (zh) | 2006-12-20 |
| CN1882352B true CN1882352B (zh) | 2010-08-04 |
Family
ID=90001707
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN200480034039XA Expired - Fee Related CN1882352B (zh) | 2003-11-20 | 2004-11-18 | 用于治疗多发性硬化的包含透明质酸锌复合物的药物组合物 |
Country Status (20)
| Country | Link |
|---|---|
| US (1) | US20070123488A1 (de) |
| EP (1) | EP1699468B1 (de) |
| JP (1) | JP4778908B2 (de) |
| CN (1) | CN1882352B (de) |
| AT (1) | ATE359800T1 (de) |
| CY (1) | CY1106617T1 (de) |
| DE (1) | DE602004006024T2 (de) |
| DK (1) | DK1699468T3 (de) |
| EA (1) | EA009209B1 (de) |
| ES (1) | ES2286698T3 (de) |
| HK (1) | HK1098352A1 (de) |
| HR (1) | HRP20070291T3 (de) |
| HU (1) | HUP0303779A2 (de) |
| NO (1) | NO336121B1 (de) |
| PL (1) | PL1699468T3 (de) |
| PT (1) | PT1699468E (de) |
| RS (2) | RS20060325A (de) |
| SI (1) | SI1699468T1 (de) |
| UA (1) | UA83516C2 (de) |
| WO (1) | WO2005049047A1 (de) |
Families Citing this family (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US20070099867A1 (en) * | 2005-05-24 | 2007-05-03 | Glycoscience Laboratories, Inc. | Pharmaceutical agent containing hyaluronan as an active ingredient |
| JP2007153761A (ja) * | 2005-12-01 | 2007-06-21 | Toshitsu Kagaku Kenkyusho:Kk | シナプス伝達促進剤及びシナプス保護剤 |
| CA2560844C (en) * | 2005-09-26 | 2011-05-17 | Glycoscience Laboratories, Inc. | Pharmaceutical agent containing hyaluronan as an active ingredient |
| JP2009091248A (ja) * | 2006-01-17 | 2009-04-30 | Toshitsu Kagaku Kenkyusho:Kk | 外傷性神経障害および／または運動機能障害の治療薬 |
| US8153614B2 (en) | 2006-12-05 | 2012-04-10 | Glycoscience Laboratories, Inc. | Treatment of osteoarthritis |
| JP2007277258A (ja) * | 2007-06-20 | 2007-10-25 | Toshitsu Kagaku Kenkyusho:Kk | 炎症及び神経疾患の治療剤及び予防剤 |
| ES2612001T4 (es) * | 2009-08-20 | 2018-02-07 | Yeda Research & Development Company, Ltd. | Terapia de baja frecuencia con acetato de glatirámero |
| CN111647100B (zh) * | 2020-07-14 | 2022-03-01 | 山东华熙海御生物医药有限公司 | 一种高分子量透明质酸锌的制备方法 |
Citations (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1045394A (zh) * | 1989-02-24 | 1990-09-19 | 格德昂·理查德化学工厂股份公司 | 含透明质酸缔合物的新组合物及其制法 |
| CN1254285A (zh) * | 1997-04-29 | 2000-05-24 | 里克特格登化工有限公司 | 透明质酸锌抗消化性溃疡的应用 |
| CN1343122A (zh) * | 1999-03-10 | 2002-04-03 | 高田制药株式会社 | 关节性疾病治疗剂 |
Family Cites Families (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US6013641A (en) * | 1995-09-28 | 2000-01-11 | Sangstat Medical Corporation | Use of hyaluronic acid as an immunosuppressant |
| DE19721099C2 (de) * | 1997-05-20 | 1999-12-02 | Fumapharm Ag Muri | Verwendung von Fumarsäurederivaten |
| JP2001163789A (ja) * | 1999-12-13 | 2001-06-19 | Maruho Co Ltd | マトリックスメタロプロテアーゼ阻害用医薬組成物 |
| BG104880A (en) * | 2000-10-24 | 2002-04-30 | Иван ХРИСТОВ | Medicamentous preparation for multiple sclerosis treatment |
| WO2002074318A1 (fr) * | 2001-03-15 | 2002-09-26 | Seikagaku Corporation | Agents de regulation d'expression d'il-12 |
-
2003
- 2003-11-20 HU HU0303779A patent/HUP0303779A2/hu unknown
-
2004
- 2004-11-18 EP EP04798745A patent/EP1699468B1/de active Active
- 2004-11-18 RS YUP-2006/0325A patent/RS20060325A/sr unknown
- 2004-11-18 PT PT04798745T patent/PT1699468E/pt unknown
- 2004-11-18 PL PL04798745T patent/PL1699468T3/pl unknown
- 2004-11-18 CN CN200480034039XA patent/CN1882352B/zh not_active Expired - Fee Related
- 2004-11-18 ES ES04798745T patent/ES2286698T3/es active Active
- 2004-11-18 UA UAA200606730A patent/UA83516C2/uk unknown
- 2004-11-18 WO PCT/HU2004/000107 patent/WO2005049047A1/en active Application Filing
- 2004-11-18 DE DE602004006024T patent/DE602004006024T2/de active Active
- 2004-11-18 AT AT04798745T patent/ATE359800T1/de active
- 2004-11-18 US US10/579,256 patent/US20070123488A1/en not_active Abandoned
- 2004-11-18 SI SI200430325T patent/SI1699468T1/sl unknown
- 2004-11-18 DK DK04798745T patent/DK1699468T3/da active
- 2004-11-18 JP JP2006540634A patent/JP4778908B2/ja not_active Expired - Fee Related
- 2004-11-18 EA EA200600998A patent/EA009209B1/ru not_active IP Right Cessation
- 2004-11-18 RS RSP-2007/0270A patent/RS50523B/sr unknown
-
2006
- 2006-06-19 NO NO20062857A patent/NO336121B1/no not_active IP Right Cessation
-
2007
- 2007-05-04 HK HK07104747.1A patent/HK1098352A1/xx not_active IP Right Cessation
- 2007-05-23 CY CY20071100698T patent/CY1106617T1/el unknown
- 2007-07-03 HR HR20070291T patent/HRP20070291T3/xx unknown
Patent Citations (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1045394A (zh) * | 1989-02-24 | 1990-09-19 | 格德昂·理查德化学工厂股份公司 | 含透明质酸缔合物的新组合物及其制法 |
| CN1086422A (zh) * | 1989-02-24 | 1994-05-11 | 格德昂·理查德化学工厂股份公司 | 含透明质酸配合物的药物组合物的制备方法 |
| CN1254285A (zh) * | 1997-04-29 | 2000-05-24 | 里克特格登化工有限公司 | 透明质酸锌抗消化性溃疡的应用 |
| CN1343122A (zh) * | 1999-03-10 | 2002-04-03 | 高田制药株式会社 | 关节性疾病治疗剂 |
Also Published As
| Publication number | Publication date |
|---|---|
| HUP0303779A2 (en) | 2006-02-28 |
| WO2005049047A1 (en) | 2005-06-02 |
| DE602004006024T2 (de) | 2007-12-27 |
| NO336121B1 (no) | 2015-05-18 |
| EP1699468B1 (de) | 2007-04-18 |
| RS20060325A (en) | 2008-08-07 |
| CN1882352A (zh) | 2006-12-20 |
| HUP0303779D0 (en) | 2004-03-01 |
| DK1699468T3 (da) | 2007-09-03 |
| EA200600998A1 (ru) | 2006-10-27 |
| PL1699468T3 (pl) | 2007-09-28 |
| ES2286698T3 (es) | 2007-12-01 |
| NO20062857L (no) | 2006-08-18 |
| US20070123488A1 (en) | 2007-05-31 |
| HRP20070291T3 (en) | 2007-10-31 |
| SI1699468T1 (sl) | 2007-08-31 |
| RS50523B (sr) | 2010-05-07 |
| UA83516C2 (uk) | 2008-07-25 |
| HK1098352A1 (en) | 2007-07-20 |
| DE602004006024D1 (de) | 2007-05-31 |
| EA009209B1 (ru) | 2007-12-28 |
| ATE359800T1 (de) | 2007-05-15 |
| JP4778908B2 (ja) | 2011-09-21 |
| CY1106617T1 (el) | 2012-01-25 |
| JP2007512311A (ja) | 2007-05-17 |
| PT1699468E (pt) | 2007-06-05 |
| EP1699468A1 (de) | 2006-09-13 |
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