CN1876033A - Compound Chinese preparation with gingko, its preparation method and use - Google Patents
Compound Chinese preparation with gingko, its preparation method and use Download PDFInfo
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Abstract
The invention relates to a medicinal ginkgo leaf compound preparation, its preparation process and use. The preparation is prepared from ginkgo extract, ginseng leaves and root of herbaceous peony. The preparation can be used for treating coronary disease, hypertension, angina pectoris, cerebral embolism and cerebral arteriosclerosis.
Description
Technical field
The present invention relates to a kind of compound gingkgo Chinese medicine preparation, preparation method and purposes.
Technical background
Semen Ginkgo (Ginkgo biloba L.) is a glacial epoch survival Relict Plant on earth, have the title of " living fossil ".Put down in writing Semen Ginkgo " its nature and flavor sweetness and bitterness and puckery is gone into lung, kidney two warps, have that relieving asthma and cough, leukorrhagia stopping are turbid, the effect of urine reducing " in the Compendium of Material Medica.Record Folium Ginkgo in " Bencao Pinhui Jingyao " " sweet-bitter flavor, puckery, property flat, returns lung meridian, can astringe the lung relieving asthma, beneficial heart pain relieving, removing dampness stopping leak ".China is the cradle of Semen Ginkgo, and resource accounts for about 70% of world's total amount.Report Folium Ginkgo flavone glycoside has obvious blood fat reducing, cholesterol reducing effect, increases the coronary blood liquid measure, reduces myocardial oxygen consumption, microcirculation improvement.It still is a kind of free radical scavenger, so defying age, antitumaous effect are arranged.BN-52021 is the antagonist of platelet activating factor (PAF), has anticoagulation, reduces blood viscosity, improves blood flowing characteristic, prevents thrombosis, promotes thrombolytic effect.Thereby since the eighties, Folium Ginkgo extract and preparation have become the focus of the world of medicine's research and development.Folium Ginkgo extract (GBE) is listed in treatment cardiovascular and cerebrovascular disease, dementia and antidotal important drugs.Be applicable to ischemic cardio cerebrovascular diseases, hypertension, hyperlipidemia, arteriosclerosis, coronary heart disease, angina pectoris, cerebral embolism, cerebral vasospasm, brain insufficiency, alzheimer disease, parkinson, apoplexy, myocardial infarction, allergic asthma, prolonged application can hypermnesis, slow down aging.And life-time service has no side effect.The research and development of Semen Ginkgo become in the world one of plant amedica hot of research and development in modern age.The potentiality of following ginkgo agent exploitation, development prospect has become the focus that people pay close attention in the world wide.
At present, international Semen Ginkgo goods have reached kind more than 30, and the relevant expert thinks annual sales amount 20～4,000,000,000 dollar of ginkgo agent in the world.The domestic ginkgo leaf extract preparation that has gone on the market mainly contains tablet, capsule, oral liquid, injection (little pin).
Along with the aging of population structure, and the anxiety of work, cardiovascular and cerebrovascular disease is also proportional to be increased, and cardiovascular and cerebrovascular diseases such as hypertension, coronary heart disease have become first killer of harm humans health.This disease also can be brought out diseases such as the heart, brain, kidney of all deceitful and life, is seriously threatening the improvement of people's health and quality of life.Will fundamentally eliminate healthy killer, improve quality of life, it is more urgent especially to seek prophylactico-therapeutic measures concerning middle-aged and elderly people.The development of this product will have a tremendous social and economic benefits.
Folium Ginkgo concentrated extract sheet includes bioflavonoids, comprise ginkgetin, ginkgolide and antioxidant complex. it can promote the blood oxygen flow of brain, prevent such as alzheimer's psychosis (senile dementia) relevant with the age, and can weaken the disease of people's the mental status. Semen Ginkgo all has plantation in China various places, but utilize Folium Ginkgo extract to make health food purely, at home seldom.
Folium Ginseng, QI invigorating, lung benefiting drives away summer heat, and promotes the production of body fluid, and is used for the summer-heat agitation, and Tianjin wound is thirsty, and the head is unclear, and extremity are tired weary.
The Radix Paeoniae Alba is the dry root of cohosh Radix Paeoniae Paeonia lactiflora Pall..Summer, Qiu Erji excavate, and clean, and remove and reach radicula end to end, put and boil after removing crust or peeling after boiling in the boiling water again, dry.The character feeble QI, is slightly cold at mildly bitter flavor, acid.Return liver, spleen channel.Cure mainly the suppressing the hyperactive liver pain relieving, nourishing blood for regulating menstruation, astringing YIN to stop sweating.Dizzy, hypochondriac pain, stomachache, limb pain twin, blood deficiency and yellow complexion, menoxenia, spontaneous perspiration, night sweat are used to have a headache.
Compound gingko leaf preparation of the present invention be on the basis of single gingko leaf preparation added Chinese medicines such as the Radix Ginseng soap and the Radix Paeoniae Alba, increased blood circulation promoting and blood stasis dispelling, allevating angina pectoris improves effects such as energy aroused in interest.
Summary of the invention
The objective of the invention is to provide a kind of compound folium ginkgo Chinese medicine preparation.
Purpose of the present invention also provides a kind of above-mentioned preparation method.
Another object of the present invention is that a kind of above-mentioned purposes is provided.
Compound folium ginkgo Chinese medicine preparation of the present invention adopts monarch drug Semen Ginkgo extrac sweet in the mouth bitterness, and property is flat, GUIXIN, lung meridian, astringe the lung relieving asthma, effect of dissolving stasis and relieving pain.Have coronary artery dilator and peripheral blood vessel, anticoagulant and thrombotic effect.The ministerial drug Folium Ginseng invigorates vital energy and reinforce the heart, drives away summer heat and promote the production of body fluid, and regulates nervus centralis, and it is thirsty to be used for Tianjin wound, and extremity are tired weary.In case of necessity, can also add Radix Paeoniae Alba nourishing yin for softening liver, suppressing the hyperactive liver pain relieving, nourish blood and blood, astringing YIN to stop sweating makes for assistant.Blood circulation promoting and blood stasis dispelling is played, dredging the meridian, the effect of promoting the circulation of QI to relieve pain altogether by full side.
Compound folium ginkgo Chinese medicine preparation of the present invention, by monarch drug Folium Ginkgo extract, ministerial drug extract of Radix Ginseng leaf and assistant Radix Paeoniae Alba extract and starch are formed, wherein the weight ratio of Folium Ginkgo extract, extract of Radix Ginseng leaf, Radix Paeoniae Alba extract and starch is 15～20: 12～18: 25～35: 0～110.Recommending the weight ratio of Folium Ginkgo extract, extract of Radix Ginseng leaf, Radix Paeoniae Alba extract and starch is 18.75: 15: 32: 98～100.
The preparation method of compound folium ginkgo Chinese medicine preparation of the present invention is with extract of Radix Ginseng leaf, the mixing that stirs of Semen Ginkgo extrac, starch and the Radix Paeoniae Alba, and drying or vacuum drying are ground into powder or fill capsule again, become powder or capsule.Wherein, the weight ratio of described Folium Ginkgo extract, extract of Radix Ginseng leaf, Radix Paeoniae Alba extract and starch is 15～20: 12～18: 25～35: 0～110.Recommending the weight ratio of Folium Ginkgo extract, extract of Radix Ginseng leaf, Radix Paeoniae Alba extract and starch is 18.75: 15: 32: 98～100.Vacuum drying temperature with 60 ℃ ± 5 ℃ for well.
When mixing in the formulation method, paying attention to Semen Ginkgo extrac, extract of Radix Ginseng leaf and starch fully stirs earlier, it is evenly distributed, again Radix Paeoniae Alba extract is used an amount of ethanol dilution, employing contains 30～50% Radix Paeoniae Alba ethanol extract and drops in the said mixture, further stir, make the maximum uniform distribution of monarch drug Folium Ginkgo extract.
Folium Ginseng, QI invigorating, lung benefiting, drive away summer heat, promote the production of body fluid, be used for the summer-heat agitation, Tianjin wound is thirsty, and the head is unclear, and extremity are tired weary, adopt decocting to boil three times, for utilizing the ginsenoside to have certain dissolubility in water, the ginsenoside extracts as far as possible with active ingredient, and non-effective part of insoluble characteristic in high concentration alcohol such as chlorophyll in the decocting liquid, adopt the traditional handicraft of water extract-alcohol precipitation, preparation and getting.As Folium Ginseng 312.5g is decocted three times, add 15 times of amounts of water at every turn, boil back insulation 1 hour at every turn; Filtrate concentrating is evaporated to an amount of, is chilled to 40 ℃, adds ethanol, makes to contain the alcohol amount to 80%, fully stirs evenly, and places 24 hours, and the leaching supernatant concentrates the dense acquisition 15kg extract of decompression.
The Radix Paeoniae Alba breaks into coarse powder.Ethanol oozes the deer method and extracts active ingredient Radix Paeoniae general glycoside, as uses 70% ethanol extraction, has avoided in the Radix Paeoniae Alba toughness compositions such as starch contained therein, resin, phlegmatic temperament, protein and sugar to the influence of finished product disintegration.Control percolate flow velocity, per kilogram crude drug per minute 1～3ml, it is shallow to annotate color to percolation, stops to collect percolate.
Compound folium ginkgo Chinese medicine preparation preparation method of the present invention is easy, and preparation is pale brown color or chocolate brown powder, bitter in the mouth.Have blood circulation promoting and blood stasis dispelling, dredging the meridian, promoting the circulation of QI to relieve pain.Cardiovascular and cerebrovascular vessel there is the improvement effect of expressing.Be used to prevent and treat coronary heart disease, hypertension, angina pectoris, cerebral embolism, cerebral arteriosclerosis and because of relevant internal organs (liver, kidney, face, osteoarthrosis, skin etc.) disease due to the stagnation of QI-blood.Function with cure mainly: activating blood circulation to dissipate blood stasis and dredge the collateral.Be used for the thoracic obstruction that obstruction of collaterals by blood stasis causes, pained, apoplexy, hemiplegia, stiff tongue and retardation in speech; Coronary heart disease stable type heart stricture of vagina pain, cerebral infarction are seen above-mentioned patient.
The specific embodiment
Following embodiment further specifies the present invention, is limited to content of the present invention but can not limit.
The preparation of embodiment 1 Folium Ginkgo extract
Folium Ginkgo extract can be by commercially available, or, get Folium Ginkgo by known compound recipe, pulverize, use the Diluted Alcohol heating and refluxing extraction, merge extractive liquid,, recovery ethanol also is concentrated in right amount, is added on the macroporous adsorptive resins of having handled well, water and Different concentrations of alcohol eluting successively, collect corresponding eluent, reclaim ethanol, spray drying; Or recovery ethanol, being condensed into thick paste, vacuum drying is pulverized, promptly.
The preparation of embodiment 2 compound gingko leaf preparations
The compound gingkgo capsule seals at normal temperatures to be preserved 1 year, and the quality of the pharmaceutical preparations is stable, thus storage requirement to draft by the hospital preparation routine be sealing, effect duration is 1 year.
Get crude drug Folium Ginseng 312.5g, decoct with water three times, add 15 times of amounts of water at every turn, boil back insulation 1 hour, collecting decoction filters at every turn, filtrate is concentrated in right amount, is chilled to 40 ℃, adds ethanol, make to contain the alcohol amount, fully stir evenly, placed 24 hours to 80%, the leaching supernatant, reclaim ethanol to there not being the alcohol flavor, and to be condensed into relative density be 1.30～1.35, the extractum of (80 ℃).Vacuum drying (60 ℃ ± 5 ℃), dried cream powder is broken into fine powder, and is standby.
Other gets crude drug Radix Paeoniae Alba 37.5g, is ground into coarse powder, uses 70% ethanol percolate extraction.The ethanol extract 80kg that must contain 40% Radix Paeoniae Alba.
Get above-mentioned extract of Radix Ginseng leaf, add commercially available Semen Ginkgo extrac 37.5g, stir, above-mentioned Radix Paeoniae Alba extractum stirs, and at 60 ℃ ± 5 ℃ vacuum dryings, is ground into middle powder, and filled capsules promptly gets 1000 seed lac wafers.
The preparation of embodiment 3 compound gingko leaf preparations
Get Folium Ginseng 156kg, decoct with water three times, add 15 times of amounts of water at every turn, boil back insulation 1 hour, collecting decoction filters at every turn, filtrate is concentrated in right amount, is chilled to 40 ℃, adds ethanol, make to contain the alcohol amount, fully stir evenly, placed 24 hours to 80%, the leaching supernatant, reclaim ethanol to there not being the alcohol flavor, and to be condensed into relative density be 1.30～1.35, the extractum of (80 ℃).Vacuum drying (60 ℃ ± 5 ℃), dried cream powder is broken into fine powder 15kg, and is standby.
Other gets Radix Paeoniae Alba 625kg, is ground into coarse powder, uses 70% ethanol percolate extraction.The ethanol extract 80kg that must contain 40% Radix Paeoniae Alba.
Get extract of Radix Ginseng leaf, add Semen Ginkgo extrac 18.75kg, 98～100kg starch and the suitable water yield, stir, drop into the above-mentioned Radix Paeoniae Alba extractum 80kg that has diluted and stir,, be ground into middle powder at 60 ℃ ± 5 ℃ vacuum dryings, filled capsules promptly gets 500,000 seed lac wafers, every 0.33g.
Character: this product is a capsule, and content is pale brown color or chocolate brown powder, bitter in the mouth.
Embodiment 3 clinical brief summaries
Adopt the compound gingko leaf preparation of embodiment 2, added Chinese medicines such as the Radix Ginseng soap and the Radix Paeoniae Alba, increased blood circulation promoting and blood stasis dispelling, allevating angina pectoris improves effects such as energy aroused in interest.This group is inquired into application QOL by the effect of compound gingko leaf preparation treatment coronary heart disease and is translated the effect of estimating medicine for cardiovascular system.
Data and method
Treatment target: this group angina pectoris patient 120 examples are divided into two groups at random.First group of 60 example, male 30 examples, women 30 examples, age 44-76 (average 59.2 ± 8.1 years old); Second group of 60 example, male 32 examples, women 28 examples, age 45-74 (average 60.1 ± 7.5 years old); Every group all contains old myocardial infarction 16 examples, unstable angina pectoris 20 examples, latent qualitative angina pectoris 24 examples.
Therapeutic Method: treat inactive other medicaments for resisting myocardial ischemia except that the nitroglycerin buccal tablet of first three day.All take each 2 of compound gingkgo capsule, 3 times on the one, 5 weeks of the course of treatment for two groups.Second group of patient is except that taking the compound gingkgo capsule, add and use biofeedback therapy, method instruct the patient to carry out the training of three line relaxation merit, and the JD-PW5 type senior computer biofeed back instrument that application Boda Technical Inst., Beijing produces carries out test for by special audiotape, one time 30 minutes, every day 1 time, totally 10 times, the next day of thereafter 1 time, finish up to the course of treatment, each training end front and back are said by the full-time staff and are translated.
Observed content:
1, quality of life translates and decides questionnaire: comprise 14 kinds of common symptoms of cardiovascular diseases, by the degree weight, remember that respectively energy worker record is very heavy, heavier, medium, light, do not have 5 other score of level.
2, " (ADL): to the degree of difficulty of 14 kinds of daily life disposal abilities such as doing housework, have a meal, wear the clothes, have a bath, count the 1-4 branch respectively, the whirlpool is divided into 56 fens to the energy strength rubbish of daily life.
3, Ka Shi energy aroused in interest score sheet (KPS): can score to the aroused in interest of patient, to moribund condition (1 minute), count the 1-10 branch respectively from normal activity (10 minutes).
4, psychohygiene is from translating scale (SCL-90): this scale contains 90 topics, and reflection is melancholy, anxiety, terror, bigoted, force and contents such as somatization symptom and inter personal contact.Efficacy assessment standard:
1, QOL questionnaire produce effects: transference cure or more than time step worker level; Effectively: more than the doing well,improving progress higher level; Invalid: as not cross above standard.
2, angina pectoris produce effects: angina pectoris disappears or basic the disappearance, substantially without nitroglycerin; Effectively: angina pectoris symptom reduces by 1 grade, and the nitroglycerin consumption reduces by half above, and is invalid: do not reach above standard.
3, electrocardiogram produce effects; Treatment back resting electrocardiogram ST-T ischemic change disappears or is roughly normal, or more than the ST section rise 0.1mv; Effectively; More than the ST section rise 0.05mv, but do not reach arm's length standard, or the T ripple be inverted to become to connect and reaches more than 50%, invalid: as not reach above standard.
The result
The 1st group of patient's 60 examples are single compound gingkgo Capsules group of using.
The 2nd group of patient's 60 examples are just to use the compound gingkgo capsule and use the biofeedback therapy group.
One, the treatment anginal change in back sees Table 1
Table 1 angina pectoris treatment result
| Group | The produce effects number | Obvious effective rate (%) | Significant figure | Invalid number | Effective percentage (%) |
| The 1st group (n=60) | 24 | 40.0 | 26 | 10 | 83.3 |
| The 2nd group (n=60) | 30 | 50.0 | 26 | 4 | 93.3 |
Can find that from obvious effective rate and total effective rate the 2nd group adds with behind the biofeedback technology, curative effect improves 10%.
Two, the various anginal tables 2 that turn about in treatment back
The various angina pectoris treatment results of table 2
| Group | The produce effects number | Obvious effective rate (%) | Significant figure | Invalid number | Effective percentage (%) |
| The 1st group of old (n=16) | 6 | 37.5 | 8 | 2 | 87.5 |
| The 2nd group of heart infarction (n=16) | 8 | 50.0 | 8 | 0 | 100.0 |
| The 1st group of unstability (n=20) | 10 | 50.0 | 6 | 4 | 80.0 |
| The 2nd group of angina pectoris (n=20) | 10 | 50.0 | 8 | 2 | 90.0 |
| The 1st group (n=24) of stability | 8 | 30.8 | 12 | 4 | 83.1 |
| The 2nd group of angina pectoris (n=24) | 12 | 50.0 | 10 | 2 | 91.6 |
Three, treatment back ischaemic ECG change the results are shown in Table 3
The table 3 treatment Electrocardiographic change in back
| Group | The produce effects number | Obvious effective rate (%) | Significant figure | Invalid number | Effective percentage (%) |
| The 1st group (n=60) | 12 | 20.0 | 22 | 26 | 56.6 |
| The 2nd group (n=60) | 14 | 23.3 | 24 | 22 | 63.3 |
Therapeutic outcome shows, adds with curative effect behind the biofeedback technology and improves (P＜0.05).
Four, the treatment hemorheological change in back sees Table 4
Table 4 treatment back blood becomes the change of learning
| Group | Whole blood (ratio) viscosity | The P value | Blood plasma (ratio) viscosity | The P value | Blood+pull and assemble test (%) | The P value |
| After controlling before controlling | After controlling before controlling | After controlling before controlling | ||||
| The 1st group (n=30) | 7.31±0.81 6.68±0.91 | ＜0.05 | 2.08±0.21 1.84±0.27 | ＜0.05 | 76.74±10.16 62.54±12.46 | ＜0.05 |
| The 2nd group (n=30) | 7.47±0.92 6.32±0.86 | ＜0.01 | 2.16±0.32 1.64±0.31 | ＜0.01 | 78.48±9.65 54.37±13.24 | ＜0.01 |
| The P value | ＜0.05 | ＜0.05 | ＜0.05 | |||
Five, the change of treatment back serum superoxide dismutases (SOD) sees Table 5
My institute uses Shanghai puts the SOD-1 radioimmunology analysis medicine box of exempting to be produced and measures, and the serum normal value is 265.2-473.6ng/ml.
Testing result is as follows:
The change (serum) of table 5 treatment back SOD
| Group | Before controlling (ng/ml) | Control back (ng/ml) | The P value |
| The 1st group (n=60) | 241.6±105.3 | 305.7±137.5 | ＜0.05 |
| The 2nd group (n=60) | 239.8±103.6 | 348.4±165.3 | ＜0.01 |
The result shows that the average of two groups of SOD in serum is lower than normally before controlling, and therapeutic blood serum concentrations all has remarkable rising, and the 2nd group result is more remarkable.
Six, (QOL) questionnaire measurement result sees Table 6 quality of life
The change (%) that table 6 treatment back QOL measures
| Group | Uncomfortable in chest | Chest pain | Weak | Hypomnesis | Insomnia and dreamful sleep |
| The obvious effective rate effective percentage | The obvious effective rate effective percentage | The obvious effective rate effective percentage | The obvious effective rate effective percentage | The obvious effective rate effective percentage | |
| The 1st group | 50.0 28.6 | 40.0 43.3 | 62.1 24.1 | 55.0 30.0 | 46.1 38.4 |
| Effective percentage | 78.6 | 83.3 | 86.2 | 85.0 | 84.5 |
| The 2nd group | 67.9 28.6 | 50.0 43.3 | 75.9 17.1 | 73.3 17.2 | 84.6 11.5 |
| Effective percentage | 96.5 | 93.3 | 93.1 | 90.5 | 96.1 |
Select 5 kinds of symptoms of related intimate in 14 kinds of symptoms of QOL questionnaire, the change after the treatment sees Table 6, and P value is equal＜0.05-0.01
Seven, the change of ADL and KPS integration sees Table 7
The change of the secret KPS integration of table 7 treatment back ADL
| Group | ADL | The P value | KPS | The P value |
| After controlling before controlling | After controlling before controlling | |||
| The 1st group (n=60) | 50.60±7.83 49.12±6.38 | ＜0.05 | 6.27±0.83 7.15±0.94 | ＜0.05 |
| The 2nd group (n=60) | 50.83±8.46 48.34±6.14 | ＜0.01 | 6.29±0.57 8.03±1.06 | ＜0.01 |
| The P value | ＜0.05 | ＜0.05 | ||
The result of table 7 shows, activity of daily living and aroused in interest can all having made marked progress that the treatment back is two groups, and the comparison of two groups of treatment front and back differences adds with curative effect behind the biofeedback technology and improves significantly.
Eight, the change after the psychological indicator treatment sees Table 8
The change of table 8 treatment back SCL-90 integration
| Total points | A | D | E | F | |
| The 1st group | |||||
| Before controlling | 117.25± 23.897 | 19.85± 4.815 | 16.70± 4.414 | 12.45± 4.071 | 10.10± 3.194 |
| After controlling | 115.20± 21.879 | 19.34± 4.183 | 15.06± 4.188 | 11.40± 3.747 | 9.55± 2.907 |
| The P value | ＜0.05 | ＞0.05 | ＜0.05 | ＜0.05 | ＞0.05 |
| The 2nd group | |||||
| Before controlling | 199.22± 20.02 | 28.35± 10.40 | 36.90± 8.379 | 33.35±8.79 | 19.56± 8.61 |
| After controlling | 195.45± 20.20 | 25.45± 9.64 | 32.25± 6.887 | 28.80±7.92 | 17.65± 7.56 |
| The P value | ＜0.01 | ＜0.05 | ＜0.01 | ＜0.01 | ＜0.05 |
SCl-90 comprises 10 subscales, and this group will be drawn with closer total points and 4 subscales of QOL relation.Go out, A refers to somatization symptom, and D refers to depressive symptom, and E refers to anxiety symptom, symptom that F refers to hostile (hootility).As seen from Table 8, add with behind the biofeedback therapy, the improvement of psychological indicator is better than the 1st group.
Nine, Zhi Liao side reaction
In the therapeutic process, some cases generation feeling of fullness in the head dizziness (the 1st group of 5 examples, the 2nd group of 4 examples) and stomach discomfort (the 1st and the 2nd group is 2 examples), but do not influence treatment, continue to adapt to gradually in the drug administration process.
Discuss
This group is used compound gingkgo capsule for treating angina pectoris patient 60 examples, and wherein the half case adds with the biofeedback technology treatment, and therapeutic outcome shows that the effective percentage of angina pectoris treatment has improved 10%, and the electrocardiogram effective percentage has improved 6.7%.The result of study prompting of this group, activity of daily living, the improvement of cardiac function and psychological indicator has all obviously surpassed simple medicine group.Use the biofeedback technology of non-drug therapy, can increase the effect of compound gingkgo capsule for treating coronary heart disease, improve patient's QOL.
This group discovers that the compound gingkgo capsule has anti-platelet activity, reduces platelet aggregation rate, reduces blood viscosity, and the effect of antioxidant radical is arranged, and obviously improves the activity of SOD.Above mechanism has and helps illustrate the effective part mechanism of compound gingkgo capsule for treating coronary heart disease and myocardial ischemia.
Claims (10)
1, a kind of compound folium ginkgo Chinese medicine preparation, adopt monarch drug Folium Ginkgo extract, ministerial drug extract of Radix Ginseng leaf and assistant that Radix Paeoniae Alba extract and starch are formed, wherein the weight ratio of Folium Ginkgo extract, extract of Radix Ginseng leaf, Radix Paeoniae Alba extract and starch is 15～20: 12～18: 25～35: 0～110.
2, compound folium ginkgo Chinese medicine preparation as claimed in claim 1, the weight ratio that it is characterized in that described Folium Ginkgo extract, extract of Radix Ginseng leaf, Radix Paeoniae Alba extract and starch is 18.75: 15: 32: 98～100.
3, the preparation method of compound folium ginkgo Chinese medicine preparation as claimed in claim 1 is characterized in that extract of Radix Ginseng leaf, the mixing that stirs of Semen Ginkgo extrac, starch and the Radix Paeoniae Alba, and drying or vacuum drying are ground into powder or fill capsule again, become powder or capsule; Wherein, the weight ratio of described Folium Ginkgo extract, extract of Radix Ginseng leaf, Radix Paeoniae Alba extract and starch is 15～20: 12～18: 25～35: 0～110.
4, the preparation method of compound folium ginkgo Chinese medicine preparation as claimed in claim 3, the weight ratio that it is characterized in that described Folium Ginkgo extract, extract of Radix Ginseng leaf, Radix Paeoniae Alba extract and starch is 18.75: 15: 32: 98～100.
5. as the preparation method of claim 3 or 4 described compound folium ginkgo Chinese medicine preparation, it is characterized in that described mixing is earlier with extract of Radix Ginseng leaf, Semen Ginkgo extrac and starch stir, again and the ethanol extract that contains 30～50% Radix Paeoniae Albas stir.
6, as the preparation method of claim 3 or 4 described compound folium ginkgo Chinese medicine preparation, it is characterized in that described vacuum drying is to carry out in the time of 60 ℃ ± 5 ℃.
7, the preparation method of compound folium ginkgo Chinese medicine preparation as claimed in claim 3 is characterized in that the described extract of Radix Ginseng leaf of getting is with Folium Ginseng, decoct with water three times, add 15 times of amounts of water at every turn, boil back insulation 0.5～1.5 hour at every turn, collecting decoction filters, and filtrate concentrates, be chilled to 40 ℃, add ethanol, make to contain the alcohol amount to 80%, fully stir evenly, placed the leaching supernatant 24 hours, and to be condensed into relative density be 1.30～1.35 extractum at 80 ℃, vacuum drying, and dried cream powder is broken into fine powder.
8, the preparation method of compound folium ginkgo Chinese medicine preparation as claimed in claim 3, the described Radix Paeoniae Alba extract of its feature is with in vain, is ground into coarse powder, uses ethanol percolate extraction, gets Radix Paeoniae Alba extractum.
9, the preparation method of compound folium ginkgo Chinese medicine preparation as claimed in claim 4, the described Radix Paeoniae Alba extract of its feature adopts 70% ethanol percolate extraction, and the percolate flow velocity is per kilogram crude drug per minute 1～3ml.
10, the purposes of compound folium ginkgo Chinese medicine preparation as claimed in claim 1 is characterized in that being used to preventing and treating coronary heart disease, hypertension, angina pectoris, cerebral embolism, cerebral arteriosclerosis and because of the medicine of the disease of relevant liver, kidney, face, osteoarthrosis or skin internal organs due to the stagnation of QI-blood.
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| CN103349127A (en) * | 2013-07-22 | 2013-10-16 | 北京绿源求证科技发展有限责任公司 | Food health preserving tea electuary for preventing osteoporosis |
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