CN1875922A - Compound ivermectin-albendazole injection for animal and preparation method thereof - Google Patents
Compound ivermectin-albendazole injection for animal and preparation method thereof Download PDFInfo
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- CN1875922A CN1875922A CN 200610014378 CN200610014378A CN1875922A CN 1875922 A CN1875922 A CN 1875922A CN 200610014378 CN200610014378 CN 200610014378 CN 200610014378 A CN200610014378 A CN 200610014378A CN 1875922 A CN1875922 A CN 1875922A
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- albendazole
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Abstract
The invention relates to an Ivermectin-febantel compound injection and process for preparation, wherein the injection is prepared from Ivermectin, febantel, glycerol formal, benzyl carbinol and methyl glycol as raw material through mixing homogeneously under predetermined conditions.
Description
Technical field
The present invention relates to a kind of anti-parasite medicine for animal use thing, especially a kind of compound ivermectin-albendazole injection for animal and preparation method thereof
Background technology
Parasitic disease is one of modal disease of animal, various parasites can cause that animal is thick disorderly by hair, fall hair, appetite reduce or useless exhausted, ruminate unusual, gastricism, become thin, vomiting, dyspnea, the faint yellow mucus nasal mucus of stream, dysentery, anemia, growth promoter symptom such as be obstructed.Avilamycin, levamisole, fenbendazole are listed in treat parasitic disease choice drug such as in various places in decades, because prolonged and repeated use causes polypide that medicine has been produced toleration, and reduced curative effect; And some existing compound anti-parasitic pharmaceutical formulations are loaded down with trivial details, and preparation relative complex and price are more expensive.
Ivermectin is the semi-synthetic Macrolide multicomponent broad-spectrum anti-parasite medicine that produces from soil microorganism A Foman streptomycete (Streptomyces avermitilis) fermentation.Ivermectin to endoparasite and ectoparasite particularly nematicide (roundworm) and arthropod have the good effect of killing, but invalid to cestode, trematodiasis and protozoacide.Its mechanism of action may be the release that increases the inhibitory transmitter gamma aminobutyric acid (GABA) of polypide, thereby the transmission of block nerves signal makes muscle cell lose contractility, and causes polypide death.Mammiferous peripheral neurotransmitter is an acetylcholine, can not be subjected to the influence of ivermectin; And ivermectin is difficult for seeing through blood brain barrier.Therefore, ivermectin injection has higher safety to domestic animal.And albendazole can be killed intravital anthelmintic such as distoma hepaticum, cestode, cysticercosis, Echinococcus hydatid cyst and the various nematicides of intestinal etc. rapidly by influencing the multiple biochemical metabolism approach of polypide.
Summary of the invention
The present invention overcomes the deficiencies in the prior art, and the compound ivermectin-albendazole injection for animal that a kind of preparation is simple, price is low, efficient, quick-acting, long-acting, insecticidal spectrum wide and be difficult for developing immunity to drugs is provided.
Another object of the present invention provides a kind of preparation method of compound ivermectin-albendazole injection for animal.
The present invention is achieved through the following technical solutions:
This compound ivermectin-albendazole injection for animal, its component constitutes and parts by weight are respectively:
Ivermectin: 5～20 parts
Albendazole: 50～200 parts
Glycerin methylal: 20～60 parts
Phenethanol: 4～15 parts
Propylene glycol: 400～600 parts.
And the preferred weight proportioning of described each component is:
Ivermectin is 10 parts, and albendazole is 120 parts, glycerin methylal: 36 parts, phenethanol is 10 parts, and propylene glycol is 550 parts.
The preparation method of this compound ivermectin-albendazole injection for animal comprises the steps:
(1). get 20～60 weight portion glycerin methylals and be heated to 30～80 ℃, add 5～20 weight portion ivermectin stirring and dissolving, add 50～200 weight portion albendazole stirring and dissolving again, form primary solution;
(2). in primary solution, add 4～15 weight portion phenethanol, and then add 400～600 weight portion propylene glycol and stir, promptly make the finished product injection.
Advantage of the present invention and beneficial effect are:
1. this compound ivermectin-albendazole injection for animal preparation is simple, price is low, is a kind of efficient, quick-acting anti-parasite medicine, and various drug-resistant worm plants are had stronger killing effect, is difficult for developing immunity to drugs after the animal injection.
2. include ivermectin in this compound ivermectin-albendazole injection for animal, thereby can particularly nematicide (roundworm) and arthropod have the good effect of killing to endoparasite and ectoparasite, do not have cross tolerance with other parasite killing, can use with albendazole is collaborative; And albendazole can be killed intravital anthelmintic such as distoma hepaticum, cestode, cysticercosis, Echinococcus hydatid cyst and the various nematicides of intestinal etc. rapidly by influencing the multiple biochemical metabolism approach of polypide.The two collaborative use has enlarged fungicidal spectrum, and made compound injection has characteristics such as wide spectrum, efficient, safety.
3. the plain injection of this animal compound ivermectin-albendazole adopts a certain amount of glycerin methylal as solvent, has the veterinary drug of raising stability, reduces viscosity, reduces the characteristic of drug residue and toxic and side effects and potentiation.
4. the plain injection of this animal compound ivermectin-albendazole has multiple parasite inside and outside the animal body and kills activity efficiently, and is easy to use and the weight of animals is increased, and fur gloss improves price of deed rate.
The specific embodiment
The present invention is described in further detail by following examples, but is not limited to following embodiment.
This compound ivermectin-albendazole injection for animal, its component constitutes and the parts by weight scope is respectively:
Ivermectin: 5～20 parts
Albendazole: 50～200 parts
Glycerin methylal: 20～60 parts
Phenethanol: 4～15 parts
Propylene glycol: 400～600 parts.
Optimization proportioning of the present invention is: ivermectin is 10 parts, and albendazole is 120 parts, glycerin methylal: 36 parts, phenethanol is 10 parts, and propylene glycol is 550 parts.
The specific embodiment of preparation injection of the present invention is:
Embodiment 1
(1) gets the 30g glycerin methylal and be heated to 80 ℃, add 8g ivermectin stirring and dissolving, add 115g albendazole stirring and dissolving, form primary solution.
(2) get the 8g phenethanol and join in the above-mentioned primary solution, the adding 550g propylene glycol that stirs is promptly made the plain injection of a kind of animal compound ivermectin-albendazole.
Embodiment 2
(1) gets the 40g glycerin methylal and be heated to 60 ℃, add 10g ivermectin stirring and dissolving, add 125g albendazole stirring and dissolving, form primary solution.
(2) get the 9g phenethanol and join in the above-mentioned primary solution, the adding 570g propylene glycol that stirs is promptly made the plain injection of a kind of animal compound ivermectin-albendazole.
Embodiment 3
(1) gets the 45g glycerin methylal and be heated to 70 ℃, add 11g ivermectin stirring and dissolving, add 130g albendazole stirring and dissolving, form primary solution.
(2) get the 11g phenethanol and join in the above-mentioned primary solution, the adding 580g propylene glycol that stirs is promptly made the plain injection of a kind of animal compound ivermectin-albendazole.
Embodiment 4
(1) gets the 55g glycerin methylal and be heated to 35 ℃, add 6g ivermectin stirring and dissolving, add 180g albendazole stirring and dissolving, form primary solution.
(2) get the 5g phenethanol and join in the above-mentioned primary solution, the adding 450g propylene glycol that stirs is promptly made the plain injection of a kind of animal compound ivermectin-albendazole.
Clinical test results:
Clinical trial adopts sheep as subjects, but the application of product of the present invention is not limited to sheep, also can be applicable to the parasitic disease treatment of other animals such as cattle, pig, dog.
Picked at random does not have other bacteriovirus infections and sheep that stress situation, but 100 of the sheep of parasitic disease symptom are arranged, and according to body condition, term, close situation was divided into three groups.
Select different injection for use, its therapeutic effect contrast sees the following form.
The plain injection group of animal compound ivermectin-albendazole and other injection for treating effect comparisons
| Numbering | Group | Mortality rate % | Inefficiency % | Effective percentage % | Cure rate % | Symptom sheep number of elements is arranged during end | The relative weight gain rate % |
| A | Do not treat (matched group) | 2 | - | - | - | - | - |
| B | The ivermectin treatment | 1 | 5.6 | 74.8 | 74.5 | 3 | 75.2 |
| C | The albendazole treatment | 2 | 3.6 | 72.2 | 70.2 | 5 | 69.4 |
| D | Animal compound ivermectin-albendazole injection treatment (embodiment 1 preparation) | 0 | 1.2 | 98.3 | 90.8 | 1 | 92.0 |
This result of the test is analyzed by statistics, plain injection group of animal compound ivermectin-albendazole and ivermectin treatment treatment of control group difference is (P≤0.01) extremely significantly, compound ivermectin-albendazole extract for treating group and albendazole extract for treating matched group significant difference (P≤0.05).
Claims (3)
1. compound ivermectin-albendazole injection for animal is characterized in that:
Its component constitutes and parts by weight are respectively:
Ivermectin: 5～20 parts
Albendazole: 50～200 parts
Glycerin methylal: 20～60 parts
Phenethanol: 4～15 parts
Propylene glycol: 400～600 parts.
2. compound ivermectin-albendazole injection for animal according to claim 1 is characterized in that: the preferred weight proportioning of described each component is:
Ivermectin is 10 parts, and albendazole is 120 parts, glycerin methylal: 36 parts, phenethanol is 10 parts, and propylene glycol is 550 parts.
3. the preparation method of a compound ivermectin-albendazole injection for animal as claimed in claim 1 is characterized in that:
Preparation method comprises the steps:
(1). get 20～60 weight portion glycerin methylals and be heated to 30～80 ℃, add 5～20 weight portion ivermectin stirring and dissolving, add 50～200 weight portion albendazole stirring and dissolving again, form primary solution;
(2). in primary solution, add 4～15 weight portion phenethanol, and then add 400～600 weight portion propylene glycol and stir, promptly make the finished product injection.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN 200610014378 CN1875922A (en) | 2006-06-20 | 2006-06-20 | Compound ivermectin-albendazole injection for animal and preparation method thereof |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN 200610014378 CN1875922A (en) | 2006-06-20 | 2006-06-20 | Compound ivermectin-albendazole injection for animal and preparation method thereof |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CN1875922A true CN1875922A (en) | 2006-12-13 |
Family
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Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN 200610014378 Pending CN1875922A (en) | 2006-06-20 | 2006-06-20 | Compound ivermectin-albendazole injection for animal and preparation method thereof |
Country Status (1)
| Country | Link |
|---|---|
| CN (1) | CN1875922A (en) |
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2006
- 2006-06-20 CN CN 200610014378 patent/CN1875922A/en active Pending
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| C02 | Deemed withdrawal of patent application after publication (patent law 2001) | ||
| WD01 | Invention patent application deemed withdrawn after publication |