CN1875916A - A whitening moisturizing composition - Google Patents
A whitening moisturizing composition Download PDFInfo
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- CN1875916A CN1875916A CN 200610035213 CN200610035213A CN1875916A CN 1875916 A CN1875916 A CN 1875916A CN 200610035213 CN200610035213 CN 200610035213 CN 200610035213 A CN200610035213 A CN 200610035213A CN 1875916 A CN1875916 A CN 1875916A
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- liposome
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Abstract
The invention relates to a skin whitening and moisture preserving composition, wherein its components include (by w/w ratio) nano level vitamin C liposome 30-35%, nano level vitamin A liposome 12-15%, nano level vitamin D-bepanthen liposome 5-8%, nano level vitamin E liposome 10-12%, and nano level nicotilamide liposome 7-9%.
Description
Technical field
The present invention relates to cosmetics, the functional additive of the cosmetics of more specifically saying so.
Background technology
The existing quite long period of history of the use of cosmetics, in the so long period of history, cosmetics are always vast women's circle personage's welcome.Along with the continuous development of various years science and technology industry, the kind of cosmetics, function, quality all along with and develop.Enter the modern times especially, traditional raw material of industry go deep into scientific research, developed into the nanoscale product, the nanoscale product has all obtained unprecedented success through the research in very wide technical field.On medicine, cosmetics also is like this, so the appearance of nano level cosmetics has made the tendency of cosmetics that a new direction has been arranged again.We know part per billion meter of 1nm=, by the material that nano microcrystalline constituted, comprise various powders materials such as metal, nonmetal, organic and inorganic and biology, and its atomic arrangement mode is different from normality.Just because of this special structure of nano material, make it to have the physical property and the special chemical property and the biological property such as light, electricity, magnetic, heat, sound, power of the not available uniqueness of traditional material.Aspect cosmetics, because of the interval between the Skin Cell is approximately 50nm, some is functional in the cosmetics, active component is to infiltrate intraepidermal high dermis, so the particle diameter of function, active substance must be less than 50nm generally at 20~30nm in the cosmetics.Because the nano-grade matter porous directly plays its special chemical property and biological property function to high dermis, effect is remarkable, and traditional cosmetics can only rest on skin surface, and penetration is poor, and effect is just not obvious.So nano level cosmetics once appearance, promptly have been subjected to social welcome.The nanoscale function, active substance adds in the cosmetics, during use, be that cosmetics are applied on the human body skin, cosmetics are subjected to body temperature and atmospheric factor effect on human body skin, its moisture evaporates rapidly, and the oil phase part branch is stayed epidermis, and oil phase part can not or film forming rapidly, and exist with the oil reservoir form, this oil reservoir is in people's life, can partly or lose in a large number in the work activities, therefore during component design, this nanoscale functional activity material addition also is that shared percentage composition is very big, in addition the person, though nano-grade matter has been seen penetration theoretically, but it is infiltration under no extraneous factor promotes, even can stay in the above-mentioned oil reservoir, or in the oil film, therefore infiltration capacity is still undesirable, and this is the very not significant major reason of effect that causes present nanoscale cosmetics.This is an one, its two be traditional skin-lightening cosmetic might as well, nano level skin-lightening cosmetic might as well, they all contain the chemical substance of whitening function, these materials all have sensitivity to oxygen, and these materials just are mixed in the cosmetics, and the opportunity of a large amount of contact oxygen is arranged, so after these Cosmetic Manufacture come out, promptly can variable color through after a while, the quality instability easily causes the untoward reaction to skin after the people uses, as allergy etc.
Summary of the invention
The purpose of this invention is to provide a kind of whitening moisturizing composition, it can utilize self capsule wall to form the thin film of sealing rapidly at skin surface, unidirectional pressure nanoscale functional activity material osmosis is gone into high dermis, increases operation rate and the skin absorbs rate reaches quick whitening skin and preserving moisture effect.
Another object of the present invention is a constant product quality, invariant color, and safety is good.
Technical solution of the present invention is that its compositions consists of (w/w):
Nanometer vitamin C liposome 30~35%
Nanometer vitamin A liposome 12~15%
Nanoscale D-panthenol liposome 5~8%
Nanometer vitamin E liposome 13~18%
Nanoscale ceramide liposome 12~15%
Nano transparent matter acid liposome 10~12%
Nanoscale nicotiamide liposome 7~9%.
Best group of the present invention becomes (w/w):
Nanometer vitamin C liposome 33%
Nanometer vitamin A liposome 13%
Nanoscale D-panthenol liposome 7%
Nanometer vitamin E liposome 15%
Nanoscale ceramide liposome 13%
Nano transparent matter acid liposome 11%
Nanoscale nicotiamide liposome 8%.
Liposome of the present invention is the material of using that belongs to field of medicaments, and it is the targeted drug carrier, belongs to a kind of novel form of targeting drug delivery system.This microgranule has the class cellularity, it is phospholipid to be dispersed in form multilamellar vesicle in the water naturally, every layer of bilayer that is lipid, separated by water between vesicle central authorities and each layer, bilayer thickness is about 4 nanometers, and people are called liposome with this bimolecular folliculus with similar biofilm structure.Liposome microgranule of the present invention is 20~30nm, less than the keratodermatitis intercellular substance, so skin is had extremely strong soft property and permeability.After liposome was applied on the skin, its cyst wall was film rupture, formed the thin film of a sealing on skin, active component unidirectional osmosis interior and deep layer cell skin effect then to epidermis, and phospholipid is stayed on the skin.These are different with common nanoscale cosmetics, common nanoscale cosmetics are after it is applied on the skin, and the nano level active component substances can be penetrated in the epidermis, also can rest in the oil layer simultaneously, therefore the amount with common nano level active component substances just must be big, and infiltration capacity is a part.The oil phase substance of ordinary cosmetics can form one deck oil reservoir on skin in addition, perhaps form film, but this film does not have the class cellularity, although so be to cover on the skin, but do not reach the degree of sealing far away, thereby the infiltration that does not produce the physical factor pressure nano level active component substances of a closed system, so functional effect is also undesirable.
The functional activity of each composition of the present composition is:
Vitamin C has skin whitening, strengthen the effect of skin elasticity, but, adopt nanotechnology to wrap up because its unstability makes in the application to have difficulties, as carrier it is brought in the skin and to go, can infiltrate skin rapidly, through deep skin, the pigmentation of inhibition skin, and make the melanin degraded, and can solve the vitamin C problem of unstable.
Vitamin A and epiderm skin cell have substantial connection, and vitamin A deficiency can cause cutaneous pigmentation, multiple mottle occurs; The excessive keratinization of skin, it is coarse that skin seems, directly be used in absorption difference on the skin outward, and zest is big, easy skin allergy, the employing nanotechnology wraps up, and as carrier it is brought into skin, can accelerate to infiltrate through skin, low to skin irritation, improve the vitamin A effect, reach dispelling stain, reduce the effect of pachylosis.
Vitamin D-pantothenylol, skin had preserve moisture, the effect of moistening can promote wound healing, has antiinflammatory action, has the normal keratinization of promotion, it is healthy more that skin seems, adopts nanotechnology to wrap up, and as carrier it brought into skin, can help the skin fast Absorption, increase its function skin.
Vitamin E, i.e. fertility alcohol, it has function in delaying senility, is used in outward that it can not work by skin on the skin, if adopt nanotechnology that VE is wrapped up, can increase exponentially as the function of slow down aging, really plays a multiplier effect.
Ceramide is good wetting agent, has very strong combination water molecule ability, it keeps skin moisture by the network structure that forms in cutin is former, adopt nanotechnology that ceramide is wrapped up, and as carrier it is brought in the skin and goes, can obviously improve drying, the situation of desquamation promotes the skin moisturizing ability, reaches the skin of preserving moisture, increase skin elasticity, the effect of delaying decrepitude of skin.
Hyaluronic acid has excellent performance of keeping humidity, adopts nanotechnology that hyaluronic acid is wrapped up, and as carrier it is brought in the skin and goes, and can prevent that skin moisture scatters and disappears, and keeps the balance of skin water environment, reaches the skin effect of preserving moisture.
The effect of nicotiamide liposome Pear Power adopts nanotechnology that nicotiamide is wrapped up, and as carrier it is brought in the skin and goes, and can promote cutaneous circulation, increases skin elasticity, replys skin whitening.
The present invention adopts a whole set of serial skin test equipment of German CK company by on probation to human body skin, carries out the whitening skin and preserving moisture measure of merit.
Sample 1: add 3% nanometer grade liposome whitening moisturizing combination agent cream frost.
Sample 2: the common whitening skin and preserving moisture cream of non-nano level frost.
Sample ligand quadrat sampling product 1 sample 2
Deionized water 85% 85%
Card ripple polyacrylic acid resin 0.5% 0.5%
Sodium carboxymethyl cellulose 0.2% 0.2%
Water solublity Jojoba oil 2% 2%
PEG400 5% 5%
Water-soluble silicon 2% 2%
Water solublity azone 1% 1%
Methyl hydroxybenzoate 0.1% 0.1%
Germall plus antiseptic 0.3% 0.3%
Triethanolamine 0.5% 0.5%
Essence 0.01% 0.01%
Nanometer liposome compositions 3%
Tradition non-nano liposome composition 3%.
Used 10 days, table 1 is with dermal melanin and haemachrome tester MX18, detects melanin content,
Table 2 is with skin oil and fat \ moisture content \ acid-base value tester Skin-PH-meter smbumeterCorneometer detection of skin water content.
Table 1 whitening effect is than imitating
Natural law | Sample 1 melanin content value (MX) | Sample 2 melanin content values (MX) |
1 | Not 190 (not being coated with) | Not 190 (not being coated with) |
2 | 164 | 181 |
3 | 133 | 165 |
4 | 107 | 160 |
5 | 89 | 154 |
6 | 72 | 144 |
7 | 56 | 138 |
8 | 42 | 124 |
9 | 31 | 104 |
10 | 28 | 95 |
The numerical value of surveying can find out that the whitening effect of sample 1 is better than sample 2 from table, and the speed of whitening is also faster than sample 2.
Table 2 moisture retention is imitated relatively
Sequence number | Sample 1 water content value (%) | Sample 2 water content values (%) |
1 | Not 23 (not being coated with) | Not 23 (not being coated with) |
2 | 26.5 | 24.3 |
3 | 31.2 | 26.7 |
4 | 36.8 | 29.3 |
5 | 45.3 | 32.4 |
6 | 49.9 | 36.8 |
7 | 57.6 | 40.6 |
8 | 61.7 | 44.9 |
9 | 65.5 | 46.7 |
10 | 70.2 | 49.1 |
The numerical value of surveying can find out that the moistening effect of sample 1 is better than sample 2 from table.
Whitening function component substances of the present invention has certain sensitivity to oxygen, reveals the empty time and has grown just easy to change, rotten.So in the general cosmetics is very much careful usefulness.And whitening composition material of the present invention is to wrap in the microgranule capsule, and is isolated with oxygen, so just do not have this problem.Through keeping sample observation, the skin whitener of nanometer liposome is preserved invariant color in 3 years, and common skin whitener is not crossed average annual all variable colors.
Compositions of the present invention has two kinds of functions, the one, preserve moisture, the 2nd, whiten, preserving moisture is the basis, preserve moisture and to promote the produce effects of whitening, it is healthy, more flexible more that skin seems, whitening effect and better, the experimental data of enumerating simple lightening compositions below is illustrated, and prescription is still done experiment with sample 1.
Whitening effect relatively
Natural law | Whitening formula (not preserving moisture) | Whitening skin and preserving moisture prescription (sample 1) |
1 | Not 190 (not being coated with) | Not 190 (not being coated with) |
2 | 169 | 164 |
3 | 160 | 133 |
4 | 151 | 107 |
5 | 135 | 89 |
6 | 122 | 72 |
7 | 101 | 56 |
8 | 86 | 42 |
9 | 62 | 31 |
10 | 41 | 28 |
Conclusion: whitening formula is poorer than whitening skin and preserving moisture prescription whitening effect.
Annotate: 1, whitening formula is the nanoscale D-panthenol fat body that removes the composition of preserving moisture in the sample 1 in the table, nano transparent matter acid liposome, nanoscale nicotiamide liposome.
2, the single raw material of whitening is good not as the composite whitening moistening effect, raw material has synergism because composite whitening is preserved moisture, catch the effect that into reaches whitening skin and preserving moisture mutually, not as the whitening effect of compound whitening skin and preserving moisture combination agent, still do experiment with sample 1 prescription as the single raw material vitamin C of whitening.
Whitening effect relatively
Sequence number | Nanometer liposome vitamin C 3% prescription | Whitening skin and preserving moisture combination agent prescription (sample 1) |
1 | Not 190 (not being coated with) | Not 190 (not being coated with) |
2 | 172 | 164 |
3 | 163 | 133 |
4 | 154 | 107 |
5 | 141 | 89 |
6 | 133 | 72 |
7 | 126 | 56 |
8 | 105 | 42 |
9 | 91 | 31 |
10 | 83 | 28 |
Conclusion: the whitening effect of nanometer vitamin C whitening skin and preserving moisture combination agent is poor.
Annotate 1: nanometer liposome vitamin C 3% prescription replaces for the nanometer grade liposome compositions in the sample 1 changes the ascorbic whitening agent composition of single nanometer liposome in the table.
Advantage of the present invention is that it can utilize self cyst wall to form the thin film of sealing rapidly at skin surface, and unidirectional pressure nano-grade matter infiltrates through high dermis, increases operation rate and the skin absorbs rate, reach the effect of quick whitening skin and preserving moisture, constant product quality, invariant color, safety is good.
The specific embodiment
Composition of the present invention is (W/W):
Implementation column one implementation column two implementation columns three
Nanometer vitamin C liposome 33% 30% 35%
Nanometer vitamin A liposome 13% 12% 15%
Nanoscale D-panthenol liposome 7% 5% 8%
Nanometer vitamin E liposome 15% 17% 13%
Nanoscale ceramide liposome 13% 15% 12%
Nano transparent matter acid liposome 11% 12% 10%
Nanoscale nicotiamide liposome 8% 9% 7%.
The present invention is used for the prescription of cosmetics:
Prescription 1 prescription 2 prescriptions 3
Deionized water 85.39% 85.39% 85.39%
Card ripple polyacrylic acid resin 0.5% 0.5% 0.5%
Sodium carboxymethyl cellulose 0.2% 0.2% 0.2%
Water solublity Jojoba oil 2% 2% 2%
PEG400 5% 5% 5%
Water-soluble silicon 2% 2% 2%
Water solublity azone 1% 1% 1%
Methyl hydroxybenzoate 0.1% 0.1% 0.1%
Germall plus antiseptic 0.3% 0.3% 0.3%
Triethanolamine 0.5% 0.5% 0.5%
Essence 0.01% 0.01% 0.01%
Nanometer vitamin C liposome 0.99% 0.9% 1.05%
Nanometer vitamin A liposome 0.39% 0.36% 0.45%
Nanoscale D-panthenol liposome 0.21% 0.15% 0.24%
Nanometer vitamin E liposome 0.45% 0.51% 0.39%
Nanoscale ceramide liposome 0.39% 0.45% 0.36%
Nano transparent matter acid liposome 0.33% 0.36% 0.3%
Nanoscale nicotiamide liposome 0.24% 0.27% 0.21%.
Claims (2)
1, a kind of whitening moisturizing composition is characterized in that consisting of (w/w):
Nanometer vitamin C liposome 30~35%
Nanometer vitamin A liposome 12~15%
Nanoscale D-panthenol liposome 5~8%
Nanometer vitamin E liposome 13~18%
Nanoscale ceramide liposome 12~15%
Nano transparent matter acid liposome 10~12%
Nanoscale nicotiamide liposome 7~9%.
2, a kind of whitening moisturizing composition according to claim 1 is characterized in that consisting of (w/w):
Nanometer vitamin C liposome 33%
Nanometer vitamin A liposome 13%
Nanoscale D-panthenol liposome 7%
Nanometer vitamin E liposome 15%
Nanoscale ceramide liposome 13%
Nano transparent matter acid liposome 11%
Nanoscale nicotiamide liposome 8%.
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CN 200610035213 CN1875916A (en) | 2006-04-27 | 2006-04-27 | A whitening moisturizing composition |
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CN 200610035213 CN1875916A (en) | 2006-04-27 | 2006-04-27 | A whitening moisturizing composition |
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Cited By (13)
Publication number | Priority date | Publication date | Assignee | Title |
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CN100536817C (en) * | 2007-12-28 | 2009-09-09 | 清华大学 | Ceramide nano liposome preparations and preparation and application thereof |
CN103932898A (en) * | 2014-04-25 | 2014-07-23 | 北京博辉瑞进生物科技有限公司 | Full-function facial mask and preparation method thereof |
CN103932909A (en) * | 2014-04-25 | 2014-07-23 | 北京博辉瑞进生物科技有限公司 | Composition for facial care and preparation method of composition |
CN103932897A (en) * | 2014-04-25 | 2014-07-23 | 北京博辉瑞进生物科技有限公司 | Composition for face moistening and preparation method thereof |
CN103976891A (en) * | 2014-04-25 | 2014-08-13 | 北京博辉瑞进生物科技有限公司 | Composition for facial repair and preparation method thereof |
CN104983591A (en) * | 2015-07-09 | 2015-10-21 | 西安艾尔菲生物科技有限公司 | Double modified beta-carotene lipidosome and preparation method thereof |
CN104997652A (en) * | 2015-07-09 | 2015-10-28 | 西安艾尔菲生物科技有限公司 | Crease resistance and moisture retention liposome, and preparation method and application thereof |
CN105662930A (en) * | 2016-04-12 | 2016-06-15 | 王璐 | Vitamin A containing skin whitening and caring cream |
CN106619149A (en) * | 2017-01-23 | 2017-05-10 | 上海应用技术大学 | Method for preparing nicotinamide-coated multivesicular liposomes |
CN108785134A (en) * | 2017-05-02 | 2018-11-13 | 上海范想贸易有限公司 | A kind of addition emulsion of makeup cosmetic |
CN109394567A (en) * | 2018-10-19 | 2019-03-01 | 天津工业大学 | A kind of preparation method and quality testing standard of multifunctional transparent matter acid liposome |
CN109568243A (en) * | 2019-01-31 | 2019-04-05 | 张鹭云 | A kind of waterless nano vitamin C face cream and preparation method thereof |
CN109875911A (en) * | 2019-01-31 | 2019-06-14 | 张鹭云 | A kind of waterless nano vitamin C face cream and preparation method thereof easily absorbed |
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2006
- 2006-04-27 CN CN 200610035213 patent/CN1875916A/en active Pending
Cited By (17)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN100536817C (en) * | 2007-12-28 | 2009-09-09 | 清华大学 | Ceramide nano liposome preparations and preparation and application thereof |
CN103932897B (en) * | 2014-04-25 | 2016-07-13 | 北京博辉瑞进生物科技有限公司 | A kind of compositions for face moisture-keeping and preparation method thereof |
CN103932897A (en) * | 2014-04-25 | 2014-07-23 | 北京博辉瑞进生物科技有限公司 | Composition for face moistening and preparation method thereof |
CN103976891A (en) * | 2014-04-25 | 2014-08-13 | 北京博辉瑞进生物科技有限公司 | Composition for facial repair and preparation method thereof |
CN103932898B (en) * | 2014-04-25 | 2016-08-24 | 北京博辉瑞进生物科技有限公司 | A kind of full effect facial mask and preparation method thereof |
CN103932909A (en) * | 2014-04-25 | 2014-07-23 | 北京博辉瑞进生物科技有限公司 | Composition for facial care and preparation method of composition |
CN103932898A (en) * | 2014-04-25 | 2014-07-23 | 北京博辉瑞进生物科技有限公司 | Full-function facial mask and preparation method thereof |
CN103932909B (en) * | 2014-04-25 | 2016-09-14 | 北京博辉瑞进生物科技有限公司 | A kind of compositions for facial-care and preparation method thereof |
CN104983591B (en) * | 2015-07-09 | 2018-08-28 | 西安艾尔菲生物科技有限公司 | A kind of dual modified beta-carotenoid lipid body and preparation method thereof |
CN104997652A (en) * | 2015-07-09 | 2015-10-28 | 西安艾尔菲生物科技有限公司 | Crease resistance and moisture retention liposome, and preparation method and application thereof |
CN104983591A (en) * | 2015-07-09 | 2015-10-21 | 西安艾尔菲生物科技有限公司 | Double modified beta-carotene lipidosome and preparation method thereof |
CN105662930A (en) * | 2016-04-12 | 2016-06-15 | 王璐 | Vitamin A containing skin whitening and caring cream |
CN106619149A (en) * | 2017-01-23 | 2017-05-10 | 上海应用技术大学 | Method for preparing nicotinamide-coated multivesicular liposomes |
CN108785134A (en) * | 2017-05-02 | 2018-11-13 | 上海范想贸易有限公司 | A kind of addition emulsion of makeup cosmetic |
CN109394567A (en) * | 2018-10-19 | 2019-03-01 | 天津工业大学 | A kind of preparation method and quality testing standard of multifunctional transparent matter acid liposome |
CN109568243A (en) * | 2019-01-31 | 2019-04-05 | 张鹭云 | A kind of waterless nano vitamin C face cream and preparation method thereof |
CN109875911A (en) * | 2019-01-31 | 2019-06-14 | 张鹭云 | A kind of waterless nano vitamin C face cream and preparation method thereof easily absorbed |
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