CN1860877A - Microemulsion of oxaetherazole and cyproconazole - Google Patents
Microemulsion of oxaetherazole and cyproconazole Download PDFInfo
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- CN1860877A CN1860877A CN 200510043519 CN200510043519A CN1860877A CN 1860877 A CN1860877 A CN 1860877A CN 200510043519 CN200510043519 CN 200510043519 CN 200510043519 A CN200510043519 A CN 200510043519A CN 1860877 A CN1860877 A CN 1860877A
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- microemulsion
- difenoconazole
- propiconazole
- emulsifier
- water
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Abstract
A microemulsion for preventing and treating the fungal diseases with high effect especially to the sheath and culm blight of paddy rice, low poison and broad spectrum contains proportionally difenoconazole, propiconazole, cosolvent, emulsifier and water.
Description
Technical field
The present invention relates to a kind of disinfectant use in agriculture novel form, She is Ji Difenoconazole, propiconazole microemulsion specifically.
Background technology
The Difenoconazole commodity are called the generation height, and its preparation has 25% Difenoconazole missible oil and 10% generation high-moisture shot agent etc.Propiconazole commodity enemy's power by name is taken off, and must pounce on that etc.Its preparation mainly is 25% must pounce on your missible oil etc.Difenoconazole, propiconazole all belong to the efficient interior broad spectrum type triazole bactericidal agent of inhaling, and have identical bactericidal mechanism, are widely used in agricultural, the control of fungal diseases such as gardening.Both have complementarity in control spectrum and effect characteristics such as aspects such as quick-acting, lasting period, have synergistic function and expanding prevention spectrum after the two is composite, and the comprehensive regulation of fungal disease is better than single agent formulation.The commercialization complex preparation is 30% Difenoconazole, propiconazole emulsifiable concentrate, and Qi Zhong Difenoconazole and propiconazole respectively account for 15%.This complex preparation can be used for grain, cotton, really, the various crop fungal disease comprehensive regulations such as vegetables.Every mu of paddy rice effective ingredient consumption 3～9 grams promptly reach desirable effect of integrated pest management to the various fungal diseases of paddy rice twice in the medication in vegetative period, and have good production-increasing function.The microemulsion formulation of Dan Difenoconazole, propiconazole composition is not appeared in the newspapers as yet.
Microemulsion is to be matrix with water, by former medicine dissolving, the homogeneous stability system that the microemulsified process forms.The micella particle diameter is less than optical wavelength in the system, so the microemulsion appearance transparent is like missible oil.Because its auxiliary agent content height, emulsified particles is little, and the opening up of its soup, wetting, infiltration and filming function are better than cream preparation, so the effective rate of utilization of its soup is higher, and its drug effect is 1.2～1.5 times of cream preparation under identical effective dose.Primary solvent is a water in the microemulsion, has not only saved a large amount of organic solvents, has reduced production cost, the also favourable pressure that alleviates environmental pollution.To the development green agriculture, keep the Agro-ecology balance and be significant.
Summary of the invention
The purpose of this invention is to provide Yi Zhong Yi Difenoconazole, propiconazole is microemulsion formulation of effective ingredient and preparation method thereof.
The main technical schemes that the present invention adopts is: replace a large amount of inflammable benzene class organic solvents with water, reduce product toxicity and production cost.Improve and produce and the storing safety; The surfactant of higher dosage and add builder and can improve the opening up of medicament, wetting, permeability improves utilization rate of active components, reduces actual dosage, thereby reaches the purpose that improves preventive effect and reduce use cost.
This invention Suo Shu De Difenoconazole, propiconazole microemulsion, Qi Zhong Difenoconazole, propiconazole are active ingredient, the weight content in preparation is respectively 1～15% and 1～15%, preferred 5～10% and 5～10%, other composition comprises cosolvent 5～30%, emulsifier 5～30%, and surplus is a water.Also can contain bleeding agent in the above-mentioned prescription, bleeding agent content 0.5～10%.
Being fit to cosolvent of the present invention is toluene, dimethylbenzene, methyl alcohol, ethanol, cyclohexanone, dimethyl formamide, any one or two kinds of combination in the dimethyl sulfoxide (DMSO).
Be fit to surfactant of the present invention and be selected from one or both or two or more compounds (as the QK-7 emulsifier) in alkylphenol polyoxyethylene series, agricultural emulsifier NO series, castor oil polyoxyethylene ether series, phenethyl phenol polyethenoxy ether formaldehyde condensation products, the dodecyl benzene sulfonate.
Being fit to bleeding agent of the present invention is azone, thiophene ketone, alkylbenzenesulfonate, aliphatic alcohol sulfate, fast penetrant T, alkylphenol polyoxyethylene, fatty alcohol-polyoxyethylene ether, dodecyl dimethyl benzyl ammonium chloride, a kind of or any two kinds combination in the tertiary amine oxide etc.
Suitable water of the present invention can be any in running water, deionized water, underground water, the distilled water.
This microemulsion can prepare ， Difenoconazole, propiconazole are dissolved with cosolvent with known preparation method, adding emulsifier, bleeding agent stir, and stirs down slowly to add excess water, fully stirs into homogeneous phase transparent liquid.The preferred using method of this microemulsion is foliage spray, and working concentration regards thing as and controlling object is generally 50～250ppm.Below in conjunction with embodiment the present invention is made more specific description, but embodiment does not limit the present invention, the percentage among the embodiment is percetage by weight.
Embodiment 1
10% Difenoconazole, propiconazole microemulsion
Difenoconazole 5%
Propiconazole microemulsion 5%
Toluene 10%
DMF 10％
QK-8 emulsifier 15%
Water adds to 100%
Preparation method: with Difenoconazole, propiconazole toluene, after the DMF dissolving, add the QK-8 emulsifier, slowly add entry after stirring evenly, be stirred well to homogeneous phase transparent liquid.
Embodiment 2
12% Difenoconazole, propiconazole microemulsion
Difenoconazole 4%
Propiconazole microemulsion 8%
Butanols 5%
OP-10 2％
QK-7 15％
Azone 1%
Water adds to 100%
The preparation method is with embodiment 1
Embodiment 3
15% Difenoconazole, propiconazole microemulsion
Difenoconazole 7%
Propiconazole microemulsion 8%
Toluene 15%
DMF 10％
QK-7 emulsifier 18%
Penetrant t 5%
Water adds to 100%
The preparation method is with embodiment 1
Embodiment 4
20% Difenoconazole, propiconazole microemulsion
Difenoconazole 10%
Propiconazole microemulsion 10%
C
10Aromatic hydrocarbons 15%
DMF 15％
OP-7 3％
QK-7 emulsifier 20%
Water adds to 100%
The preparation method is with embodiment 1
The microemulsion physicochemical property of preparation is as follows:
Outward appearance: light yellow or pale brown look homogeneous phase transparent liquid
Transparency temperature zone :-5～65 ℃
Ageing stability: seasoning is stable under the normal temperature
Low-temperature stability :-2 ℃～0 ℃ two week is not stratified, muddy.
Stability of emulsion (20 times): qualified
Microemulsion of the present invention is compared Yu Difenoconazole, propiconazole emulsifiable concentrate and is had the following advantages:
1, consumption of organic solvent reduces more than 60%, and production cost and environmental pollution reduce, and product is nonflammable, produces, stores and transports safety Property is good.
2, the effective ingredient particle diameter was usually little more than 10 times than cream preparation after medicament was converted the water dilution, and is stronger to the penetrability of target; Soup Wetability improve 20～30 times than missible oil, the soup plate-out ability is good, effective rate of utilization is high, so drug effect is higher than cream preparation. Through field test, 1500 times of liquid of 15% propiconazole microemulsion (embodiment 3) dilution are to sigatoka preventing after 20 days Effect is 92.8%, and the preventive effect of 1500 times of liquid of contrast agents 25% propiconazole emulsifiable concentrate (must pounce on you) only has 87.2%, is namely having The effective constituent consumption reduces by 40% situation, and drug effect still is better than cream preparation.
3, microemulsion is take water as matrix, alleviated that organic solvent has improved safety in utilization to the injury of young fruit and tender leaf in the cream preparation. Under field control effectiveness test microemulsion 50 μ g/ml concentration of the present invention, be 94.0% (embodiment 4) to the rice sheath blight disease preventive effect, Preventive effect is 80.7% under contrast Yao Ji Difenoconazole, the identical valid density of propiconazole emulsifiable concentrate, and namely this invention microemulsion is better than missible oil system Agent.
Claims (6)
1. Difenoconazole, propiconazole microemulsion is characterized in that comprising following composition and content (by weight):
Difenoconazole 1～15%
Propiconazole microemulsion 1～15%
Hydrotropy liquid 5～30%
Emulsifier 5～30%
Water adds to 100%
2. microemulsion according to claim 1 is characterized in that described cosolvent can be a toluene, dimethylbenzene, methyl alcohol, ethanol, cyclohexanone, dimethyl formamide, any one or two kinds of combination in the dimethyl sulfoxide (DMSO).
3. microemulsion according to claim 1 is characterized in that surfactant is selected from one or both or the two or more compounds in alkylphenol polyoxyethylene series, agricultural emulsifier NO series, castor oil polyoxyethylene ether series, phenethyl phenol polyethenoxy ether formaldehyde condensation products, the detergent alkylate nitrate.(as the QK-7 emulsifier).
4. microemulsion according to claim 1, in also containing bleeding agent, each weight percentages of components is a: Difenoconazole 1～15% to its feature also, propiconazole 1～15%, hydrotropy liquid 5～30%, emulsifier 5～30%, bleeding agent 0.5～10%, surplus is a water.
5. according to claim 1 and the described microemulsion of claim 4, it is characterized in that You imitates Cheng Fen Difenoconazole and the weight content of propiconazole in preparation more preferably 5～10% and 5～10%.
6. microemulsion according to claim 4, it is characterized in that described bleeding agent can be an azone, thiophene ketone, alkylbenzenesulfonate, aliphatic alcohol sulfate, fast penetrant T, alkylphenol polyoxyethylene, fatty alcohol-polyoxyethylene ether, dodecyl dimethyl benzyl ammonium chloride, a kind of or any two kinds combination in the tertiary amine oxide etc.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN 200510043519 CN1860877A (en) | 2005-05-12 | 2005-05-12 | Microemulsion of oxaetherazole and cyproconazole |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN 200510043519 CN1860877A (en) | 2005-05-12 | 2005-05-12 | Microemulsion of oxaetherazole and cyproconazole |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CN1860877A true CN1860877A (en) | 2006-11-15 |
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Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN 200510043519 Pending CN1860877A (en) | 2005-05-12 | 2005-05-12 | Microemulsion of oxaetherazole and cyproconazole |
Country Status (1)
| Country | Link |
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| CN (1) | CN1860877A (en) |
Cited By (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN104839170A (en) * | 2015-04-15 | 2015-08-19 | 王盼盼 | Sterilization agent for removing crisp pear calyxes and preventing diseases and insect pests caused by fungi |
| CN110839638A (en) * | 2019-10-12 | 2020-02-28 | 惠州市银农科技股份有限公司 | Microemulsion containing difenoconazole and propiconazole and preparation method thereof |
| CN114600899A (en) * | 2022-04-19 | 2022-06-10 | 涿州拜奥威生物科技有限公司 | Preparation method and application of pyraclostrobin and propiconazole microemulsion |
-
2005
- 2005-05-12 CN CN 200510043519 patent/CN1860877A/en active Pending
Cited By (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN104839170A (en) * | 2015-04-15 | 2015-08-19 | 王盼盼 | Sterilization agent for removing crisp pear calyxes and preventing diseases and insect pests caused by fungi |
| CN110839638A (en) * | 2019-10-12 | 2020-02-28 | 惠州市银农科技股份有限公司 | Microemulsion containing difenoconazole and propiconazole and preparation method thereof |
| CN114600899A (en) * | 2022-04-19 | 2022-06-10 | 涿州拜奥威生物科技有限公司 | Preparation method and application of pyraclostrobin and propiconazole microemulsion |
| CN114600899B (en) * | 2022-04-19 | 2024-03-12 | 涿州拜奥威生物科技有限公司 | Preparation method and application of pyraclostrobin and propiconazole microemulsion |
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