CN102017993A - Synergistic insecticidal compound containing pymetrozine and chlorpyrifos-methyl and application thereof - Google Patents

Abstract

The invention discloses a synergistic insecticidal compound containing pymetrozine and chlorpyrifos-methyl and application thereof. The insecticidal compound takes the pymetrozine and the chlorpyrifos-methyl as main effective components, wherein the weight ratio of the pymetrozine to the chlorpyrifos-methyl is 0.1-80:0.5-80. The insecticidal compound can generate higher synergistic action, overcomes and delays the resistance to drugs of pests, enlarges prevention and cure spectrum, has high insecticidal speed and long residual activity, reduces application cost and relieves toxicity. The synergistic insecticidal compound can prevent and cure Hemiptera pests on crops and can be especially used for preventing and curing rice plant hoppers and wheat aphids. The effect of the synergistic insecticidal compound is obviously better than that of single dose.

Description

A kind of Synergistic insecticidal compositions and application thereof that contains pyrrole aphid ketone and chlorpyrifos-methyl

Technical field

The invention belongs to pesticide field, being specifically related to a kind of is the Pesticidal combination and the application thereof of main active ingredient with pyrrole aphid ketone and chlorpyrifos-methyl.

Background technology

Pyrrole aphid ketone (pymetrozine), chemical name: (E)-4,5-dihydro-6-methyl-4-(3-pyridine methylene amino)-1,2,4-triazine-3 (2H)-ketone.Being Switzerland Novartis Co.,Ltd eliminates aphis and the new type heterocycle class insecticidal materials of aleyrodid in exploitation in 1988 anti-, has efficient, low toxicity, high selectivity, characteristics such as environmentally friendly.Its mode of action uniqueness: mainly be the feed behavior that influences insect, make its food refusal and dead.This medicine is all effective to larva and adult, and its energy rapid osmotic is in plant leaf blade, and the longevity of residure reached more than one month, and did not have any cross resistance, to the natural enemies security height.The former medicine of pyrrole aphid ketone is a white crystalline solid in the time of 20 ℃, and fusing point is 234.4 ℃, and the processing formulation is 25% wetting powder.Pyrrole aphid ketone is all effective to larva or adult, and this medicine can be penetrated in the plant leaf blade very soon, and residual effect reaches one month, because no cross resistance, to the natural enemy high safety, very suitable resistant insect control.Pyrrole aphid ketone has very high preventive effect to aphid, plant hopper, leafhopper, aleyrodid, the Chinese toon rubber of crops such as paddy rice, vegetables, cotton, wheat, fruit tree.This medicine is splendid to Semiptera insect selectivity, and the selectivity of aphid is better than best anti-aphid agent-Aphox at present, and this medicine also has good interior absorption, and its systemic activity is 2～3 times of Aphox, is more than 143 times of cypermethrin.The acute oral LD of its former medicine ₅₀Be 5820mg/kg, acute through skin LD ₅₀(24h)＞2000mg/kg.Along with the whole world is more and more paid attention to environmental protection, low toxicity, demand efficient, eco-friendly insecticidal materials increase year by year, high poison, high residue, to ecotope, and its exploitation has good prospect, will bring huge social benefit and economic benefit.But the market price of pyrrole aphid ketone is higher.

Chlorpyrifos-methyl (Chlorpyrifos-methyl) chemical name is: O, O-dimethyl-O-(3,5, the 6-trichloro-2-pyridyl) thiophosphate.Chlorpyrifos-methyl is a kind of broad spectrum insecticide medicine, by tag, stomach toxicity and stifling mode be all effective, absorption in not having, it is used for preventing and treating insect and various leaf class pest on crop on aquatic larva, fly, sanitary insect pest, mosquito (adult), the warehousing cereal.But this insecticide is longer service time, and many insects have produced pesticide resistance to it.

The Semiptera insect, as aphid, plant hopper, leafhopper etc., resistance increases gradually at present, and the agent of agricultural chemicals list descends gradually to the effect of control of insect, does not still have effective preparation for the control of Semiptera insect.

Summary of the invention

The purpose of this invention is to provide a kind of Synergistic insecticidal compositions that contains pyrrole aphid ketone and chlorpyrifos-methyl.

Another object of the present invention provides this desinsection and is combined in the application for preparing in the insecticidal materials of preventing and treating resistance Semiptera insect.

The present invention adopts following technical scheme:

A kind of Synergistic insecticidal compositions that contains pyrrole aphid ketone and chlorpyrifos-methyl, it is main active ingredient with pyrrole aphid ketone and chlorpyrifos-methyl, wherein, the weight ratio of pyrrole aphid ketone and chlorpyrifos-methyl is 0.1～80: 0.5～80.The effective ingredient of above-mentioned desinsection combination is present in the composition with the synergy effective dose.

The weight ratio preferred 1～60: 1～70 of pyrrole aphid ketone and ether chrysanthemum ester in this Synergistic insecticidal compositions, more preferably 1～30: 1～30.

In the present composition, the two percentage by weight that accounts for composition of pyrrole aphid ketone and ether chrysanthemum ester is 2～80%, is preferably 8～60%, and optimum is 20～40%.

The combination of above-mentioned desinsection is main active ingredient (active component) with pyrrole aphid ketone and chlorpyrifos-methyl and is mixed with any one formulation that allows on the agricultural chemicals with insecticides adjuvant, excipients.The preferred pulvis of formulation, wetting powder, suspending agent, missible oil and water dispersion granule.

Described auxiliary agent can adopt calcium dodecyl benzene sulfonate, alkylphenol polyoxyethylene, polyoxyethylene polyoxy third rare block compound (as farming breast 33 ^#), the one or more combinations in the polyoxyethylene nonylphenol ether, excipient comprises cyclohexanone, dimethylbenzene, solvent naphtha, water, antifreezing agent (as propane diols), deionized water etc.Above auxiliary agent, excipient and other agricultural go up known auxiliary material and can singly use or and use.

Pesticidal combination antagonism Semiptera insect of the present invention has significant preventive effect, and especially the various pests that is easy to generate resistance for rice fulgorid, aleyrodid and wheat aphid has good preventive effect; And the inhibition insect is to the pesticide resistance generation of unitary agent (pyrrole aphid ketone or chlorpyrifos-methyl).

The described Synergistic insecticidal compositions that contains pyrrole aphid ketone and chlorpyrifos-methyl is prevented and treated application, the particularly application in the insecticidal materials of preparation control water rice hopper, aleyrodid and aphid in the insecticidal materials of resistance Semiptera insect in preparation.

Pesticidal combination of the present invention compared with prior art produces following beneficial effect: (1) is compared with single agent, and the said composition insect has notable synergistic, has obviously improved control efficiency; (2) one medicines are controlled more, and a dispenser can prevent and treat various pests simultaneously, reduce control recruitment cost; (3) alternative high-toxic pesticide, and reduce the field dosage significantly, effectively reduce environmental pollution and residue of pesticide; (4) have concurrently quick-acting and long-acting; (5) compare with the agent of pyrrole aphid ketone list, produce and the use cost reduction; (6) suppress the resistance enhancing of insect to agricultural chemicals;

Embodiment

Embodiments of the invention are the methods that adopt indoor bioassay and field trial to combine.Pass through indoor bioassay, the co-toxicity coefficient after clear and definite two kinds of medicaments are composite by a certain percentage earlier; On this basis, carry out field trial again.

Embodiment 1:

Taking by weighing pyrrole aphid ketone, chlorpyrifos-methyl, to adopt the conventional formulation method to be mixed with main effectively composition quality percentage composition by different proportion be 30% pyrrole aphid ketone chlorpyrifos-methyl missible oil.Concrete ratio sees Table 1.

Adopt rice stem infusion process to measure pyrrole aphid ketone and chlorpyrifos-methyl and composite sample thereof the virulence to the paddy rice brown planthopper, every processing repeats 3 times, and every concentration is handled 30, uses LC ₅₀Value is pressed the abundant method of Sun Yun and is calculated co-toxicity coefficient:

Table 1 pyrrole aphid ketone, chlorpyrifos-methyl and composite sample thereof are to toxicity test and the co-toxicity coefficient of paddy rice brown planthopper

Data show in the table, and pyrrole aphid ketone and the chlorpyrifos-methyl back that is mixed has synergistic effect to the paddy rice brown planthopper, and three listed in table proportioning co-toxicity coefficients are all much larger than 120, so pyrrole aphid ketone and chlorpyrifos-methyl are mixed and have significant synergies.Mixed synergies maximum when the ratio of chlorpyrifos-methyl and pyrrole aphid ketone is 5: 1 wherein.

Embodiment 2:

Taking by weighing pyrrole aphid ketone, chlorpyrifos-methyl, to adopt the conventional formulation method to be mixed with main effectively composition quality percentage composition by different proportion be 30% pyrrole aphid ketone chlorpyrifos-methyl missible oil.Concrete ratio sees Table 2.

Employing is soaked the leaf dip method and is measured pyrrole aphid ketone and chlorpyrifos-methyl and composite sample thereof the virulence to wheat aphid, and every processing repeats 3 times, uses LC ₅₀Value is pressed the abundant method of Sun Yun and is calculated co-toxicity coefficient:

Table 2 pyrrole aphid ketone, chlorpyrifos-methyl and composite sample thereof are to toxicity test and the co-toxicity coefficient of paddy rice brown planthopper

Data show in the table, and pyrrole aphid ketone and the chlorpyrifos-methyl back that is mixed has synergistic effect to wheat aphid, and three listed in table proportioning co-toxicity coefficients are all much larger than 120, so pyrrole aphid ketone and chlorpyrifos-methyl are mixed and have significant synergies.Mixed synergies maximum when the ratio of chlorpyrifos-methyl and pyrrole aphid ketone is 5: 1 wherein.

Embodiment 3:

Take by weighing 4g pyrrole aphid ketone, 20g chlorpyrifos-methyl, calcium dodecyl benzene sulfonate 4g, phenethyl phenol polyethenoxy ether 3g, dimethylbenzene to 100g, the method that above raw material is prepared missible oil routinely drops in the mixing kettle mixes, and forms preparation 30% pyrrole aphid ketone chlorpyrifos-methyl missible oil.

Adopt the field trial that sample carries out control in field paddy rice small brown rice planthopper that embodiment 3 joins, the contrast medicament is 25% pyrrole aphid ketone WP and 25% chlorpyrifos-methyl EC, and concrete consumption sees Table 3, every mu of water consumption is 30kg, looks into 7 days behind the medicine 3 days, 14 days, 28 days results, result of the test sees Table 3:

Table 3 example 3 samples are to the field test results of paddy rice brown planthopper

3 pairs of paddy rice brown planthoppers of example have fabulous quick-acting as can be seen from Table 3, and the lasting period is more intense, in the field performance well, are the outstanding medicaments of control paddy rice brown planthopper.

Embodiment 4:

Adopt the field trial that sample carries out the control in field wheat aphid that embodiment 3 joins, the contrast medicament is 25% pyrrole aphid ketone WP and 25% chlorpyrifos-methyl EC, and concrete consumption sees Table 3, every mu of water consumption is 30kg, looks into 7 days behind the medicine 3 days, 14 days, 28 days results, result of the test sees Table 4:

Table 4 example 3 samples are to the field test results of wheat aphid

Example 3 samples have fabulous effect to wheat aphid as can be seen from Table 4, and the lasting period is long, in the field performance well, are the outstanding medicaments that prevents wheat aphid.

Measure through indoor synergism test and to show: water rice hopper and wheat aphid are all had significant synergistic insecticidal action by composite dose of pyrrole aphid ketone and chlorpyrifos-methyl; Field control effectiveness test equally also shows the composite dose of effect that the insecticidal effect of water rice hopper and wheat aphid all is significantly higher than corresponding single agent agricultural chemicals that the present invention is all.

Embodiment 5:

Take by weighing 0.2g pyrrole aphid ketone, 20g chlorpyrifos-methyl, wetting agent lignin 10g, naphthalene sulfonate 2g, add to 100g, above raw material is mixed in micronizer, form 20.2% pyrrole aphid ketone methyl poison wetting powder with kaolin.

Embodiment 6:

Take by weighing 78g pyrrole aphid ketone, 0.5g chlorpyrifos-methyl, calcium dodecyl benzene sulfonate 8g, phenethyl phenol polyethenoxy ether 6g, dimethylbenzene and add to 100g, the method that above raw material is prepared missible oil routinely drops in the mixing kettle mixes, and forms pyrrole aphid ketone chlorpyrifos-methyl missible oil.

Embodiment 7:

Take by weighing 2g pyrrole aphid ketone, 10g chlorpyrifos-methyl, nonyl phenol phosphate 5g, alkylphenol polyoxyethylene 4g, n-butanol 3g, the dimethylbenzene of 30g and the pyrrolidones of 20g, the xanthans of 0.1g, n-butanol and the water-soluble formation water of separating, all the other components are mixed stirring and are formed oil phase, under the clipper effect, slowly water is added in the oil phase and go, and continue to shear 10～30 minutes, form 12% pyrrole aphid ketone chlorpyrifos-methyl aqueous emulsion.

Embodiment 8:

Take by weighing 10g pyrrole aphid ketone, 30g chlorpyrifos-methyl, calcium dodecyl benzene sulfonate 5g, alkylphenol polyoxyethylene 4g, the solvent xylene of 30g and the pyrrolidones of 15g, all the other waters complement to 100g, former medicine, solvent, emulsifier, cosolvent mix stirring and form homogeneous phase transparent solution, slowly add entry then and stir the formation clear solution, be 40% pyrrole aphid ketone chlorpyrifos-methyl microemulsion.

Embodiment 9:

Take by weighing 4g pyrrole aphid ketone, 4g chlorpyrifos-methyl, calcium dodecyl benzene sulfonate 5g, phenethyl phenol polyethenoxy ether 3g, dimethylbenzene to 100g.The method that above raw material is prepared missible oil routinely drops in the mixing kettle mixes, and forms preparation 8% pyrrole aphid ketone-chlorpyrifos-methyl missible oil.

Embodiment 10:

Take by weighing 3g pyrrole aphid ketone, 30g chlorpyrifos-methyl, the 3g of lignin salt, polyoxyethylene poly-oxygen propylene aether and sulphate 4g thereof, xanthans 0.2g, ethylene glycol 10g, silica ethane 0.1g, aluminium-magnesium silicate 0.5g, water is supplied 100g, forms 33% pyrrole aphid ketone chlorpyrifos-methyl suspending agent under the effect of sand mill.

Embodiment 11:

Take by weighing 5g pyrrole aphid ketone, 60g chlorpyrifos-methyl, alkylphenol polyoxyethylene 14g, phenethyl phenol polyethenoxy ether 15g, dimethylbenzene to 100g, the method that above raw material is prepared missible oil routinely drops in the mixing kettle mixes, and forms 65% pyrrole aphid ketone chlorpyrifos-methyl missible oil.

Embodiment 12:

Take by weighing 45g pyrrole aphid ketone, 5g chlorpyrifos-methyl, the 8g of wooden sodium sulfonate, lauryl sodium sulfate 2g, ammonium sulfate 5g, polyvinyl alcohol 5g, borax 2g, kaolin 28g forms 50% pyrrole aphid ketone chlorpyrifos-methyl water dispersible granules with above raw material by the method for water dispersion granule.

Embodiment 13:

Take by weighing 25g pyrrole aphid ketone, 25g chlorpyrifos-methyl, alkylphenol polyoxyethylene 14g, phenethyl phenol polyethenoxy ether 15g, dimethylbenzene to 100g, the method that above raw material is prepared missible oil routinely drops in the mixing kettle mixes, and forms 50% pyrrole aphid ketone chlorpyrifos-methyl missible oil.

Claims (9)

1. a Synergistic insecticidal compositions that contains pyrrole aphid ketone and chlorpyrifos-methyl is characterized in that this Synergistic insecticidal compositions is main active ingredient with pyrrole aphid ketone and chlorpyrifos-methyl, and wherein, the weight ratio of pyrrole aphid ketone and chlorpyrifos-methyl is 0.1～80: 0.5～80.

2. Synergistic insecticidal compositions according to claim 1 is characterized in that the effective ingredient pyrrole aphid ketone of this Pesticidal combination and the weight ratio of chlorpyrifos-methyl are 1～60: 1～70.

3. Synergistic insecticidal compositions according to claim 2 is characterized in that the effective ingredient pyrrole aphid ketone of this Pesticidal combination and the weight ratio of chlorpyrifos-methyl are 1～30: 1～30.

4. the Synergistic insecticidal compositions that contains pyrrole aphid ketone and chlorpyrifos-methyl according to claim 1 is characterized in that the two weight percentage that accounts for composition of pyrrole aphid ketone and chlorpyrifos-methyl is 2～80%.

5. the Synergistic insecticidal compositions that contains pyrrole aphid ketone and chlorpyrifos-methyl according to claim 4 is characterized in that the two weight percentage that accounts for composition of pyrrole aphid ketone and chlorpyrifos-methyl is 8～60%.

6. the Synergistic insecticidal compositions that contains pyrrole aphid ketone and chlorpyrifos-methyl according to claim 1 is characterized in that it is that main active ingredient and insecticides adjuvant, excipients are mixed with any one formulation that allows on the agricultural chemicals with pyrrole aphid ketone and ether chrysanthemum ester.

7. the Synergistic insecticidal compositions that contains pyrrole aphid ketone and chlorpyrifos-methyl according to claim 6 is characterized in that described formulation is missible oil, suspending agent, aqueous emulsion, wetting powder, microemulsion or water dispersion granule.

8. the described Synergistic insecticidal compositions that contains pyrrole aphid ketone and chlorpyrifos-methyl of claim 1 is prevented and treated application in the insecticidal materials of resistance Semiptera insect in preparation.

9. the described application of Synergistic insecticidal compositions in the insecticidal materials of preparation control water rice hopper, aleyrodid and aphid that contains pyrrole aphid ketone and chlorpyrifos-methyl of claim 1.