CN1857561A - Osteoporosis treating medicine and its preparing method - Google Patents
Osteoporosis treating medicine and its preparing method Download PDFInfo
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- CN1857561A CN1857561A CNA2006100712251A CN200610071225A CN1857561A CN 1857561 A CN1857561 A CN 1857561A CN A2006100712251 A CNA2006100712251 A CN A2006100712251A CN 200610071225 A CN200610071225 A CN 200610071225A CN 1857561 A CN1857561 A CN 1857561A
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Abstract
The present invention discloses a kind of osteoporosis treating medicine, which is prepared with tortoise plastron glue, antler gelatin, prepared rhizome of rehmannia, Chinese yam, dogwood and other seven kinds of Chinese medicinal materials, and through drying and grinding, decocting, filtering, dissolving, concentrating, mixing, sterilizing and other steps. The medicine may be prepared into medicine powder, tablet or capsule. The present invention has unique recipe, obvious curative effect, and other advantages.
Description
[technical field]
The present invention relates to a kind of medicine for the treatment of osteoporosis, is the Chinese patent medicine of feedstock production with the animals and plants Chinese herbal medicine specifically, the invention still further relates to the preparation method of this medicine, belongs to the field of Chinese medicines.
[background technology]
Osteoporosis is meant that the bone amount in the unit volume reduces, the microstructure degeneration of osseous tissue, and the fragility of bone increases, and the mechanical strength of bone descends, and causes whole body osteodynia easily, lumbago and skelalgia, fracture, height shortens, a kind of general skeletal diseases such as hunchback too early.
Osteoporosis is a common complaint among the elderly, in China 6000～8,000 ten thousand patients is arranged, and postmenopausal women is particularly outstanding.The fracture that causes thus, particularly Hip Fracture, serious threat old people's life security, have greatly reduced their quality of life.World Health Organization (WHO) classifies osteoporosis and diabetes, cardiovascular disease jointly as and has a strong impact on one of three healthy big killers of middle-aged and elderly people.Motherland's medical science thinks that the kidney being the origin of congenital constitution, kidney governing bones, living marrow.Kidney essense foot, then bone marrow biochemistry is active, and skeleton obtains the nourishing of bone marrow and firm strong.Otherwise essence in kidney is weak, the physiological function deficiency of the kidney generating marrow and dominating bone, and form osteoporosis.So motherland's medical science is mended the strong bone of marrow and is treated osteoporosis for the purpose of effecting a permanent cure with kidney tonifying, essence replenishing.
At present to the present situation of primary disease Drug therapy and the problem that runs into:
(1) replenishes the calcium preparation therapy.Replenishing the calcium preparation therapy is the general therapy of doctor trained in Western medicine to osteoporosis.But osteoporosis has dissimilar, i.e. primary osteoporosis and secondary osteoporosis.The osteoporosis that occurs after women's menopause, the osteoporosis that elderly men takes place all belongs to primary osteoporosis.The osteoporosis that is caused by certain disease or certain inducement (as medicine) then belongs to secondary osteoporosis.
For secondary osteoporosis, as the osteoporosis that the calcium malnutrition causes, additional calcium preparation just has extraordinary curative effect.And just can not rely on additional calcium preparation to treat merely to primary osteoporosis, and excessive additional calcium preparation, what have can not form skeleton, can lead to complications harm old people's health on the contrary.
(2) controversies in hormone replacement in the elderly.Doctor trained in Western medicine thinks and postmenopausal women's decrease in estrogen causes osteoporosis, truly has curative effect with the way treatment of complementing estrogen.But estrogen can make diabetes, hyperlipidemia increase the weight of, and also can impel the hysteromyoma development, unsuitable life-time service.
(3) though the commercially available Chinese patent medicine that the individualized treatment osteoporosis is arranged, as XIANLING GUBAO (production of Guizhou pharmaceutical Co. Ltd of Tongji University), but it is not ideal enough from liver and kidney tonifying, benefiting essence and marrow, nutrition skeleton, strengthening the tendons and bones, raising sex hormone level and additional biologically actived calcium aspect, and cost an arm and a leg, general patient is difficult to bear.Most patients still blindly take simple calcium preparation, cause property and healthy unnecessary loss.So should invent and the production drug effect better, the medicine of the treatment osteoporosis that price is cheaper is selected for use for the patient.
[summary of the invention]
The object of the invention is to provide a kind of the moon with nourish liver and kidney, the sun of warming the liver kidney, and benefiting essence-blood, the benefiting essence and marrow effect, treatment is because of the essence in kidney deficiency, bone marrow inanition, the medicine of the biochemical no senile osteoporosis disease due to former of skeleton.
Another object of the present invention provides the preparation method of the medicine of this treatment osteoporosis.
Solution of the present invention is based on motherland's medical science to pathogenetic understanding of osteoporosis and Therapeutic Principle, with reference to the modern pharmacological research achievement, filters out invigorating the liver and kidney from motherland's medical treasure-house, bone and muscle strengthening, benefiting essence-blood, replenishing essence marrow, hard bone bone strengthening, the animals and plants Chinese herbal medicine of the body resistance strengthening and constitution consolidating, by the theory of Chinese medical science prescription, the square YIN and YANG in a relative equilibrium of being organized, negative and positive are trained mutually, cold not dry, be widely used, can effectively treat and alleviate senile osteoporosis disease.
Medicine of the present invention is (consumption is a weight portion) of being made by the raw material of following component:
7～20 parts of 8～25 parts of Colla cornus cervis of Colla Plastri Testudinis
8～20 parts of 10～30 portions of Rhizoma Dioscoreaes of Radix Rehmanniae Preparata
8～25 parts of 10～20 parts of Fructus Lycii of Fructus Corni
6～20 parts of 6～20 parts of Cortexs Eucommiae of Semen Cuscutae
6～20 parts in 6～15 parts of Poria of Radix Cyathulae
5～12 parts of 8～15 portions of Cortex Cinnamomis of Radix Angelicae Sinensis
The formula optimization weight proportion scope of preparation medicine of the present invention is:
12～15 parts of 10～15 parts of Colla cornus cervis of Colla Plastri Testudinis
8～15 parts of 12～25 portions of Rhizoma Dioscoreaes of Radix Rehmanniae Preparata
10～20 parts of 12～15 parts of Fructus Lycii of Fructus Corni
8～15 parts of 8～15 parts of Cortexs Eucommiae of Semen Cuscutae
8～15 parts in 8～12 parts of Poria of Radix Cyathulae
6～10 parts of 8～12 portions of Cortex Cinnamomis of Radix Angelicae Sinensis
The optimum weight proportioning of medicine of the present invention is:
12 parts of 12 parts of Colla cornus cervis of Colla Plastri Testudinis
12 parts of 24 portions of Rhizoma Dioscoreaes of Radix Rehmanniae Preparata
12 parts of 12 parts of Fructus Lycii of Fructus Corni
12 parts of 12 parts of Cortexs Eucommiae of Semen Cuscutae
10 parts in 10 parts of Poria of Radix Cyathulae
6 parts of 10 portions of Cortex Cinnamomis of Radix Angelicae Sinensis
The preparation method of medicine of the present invention is:
(1) earlier Colla Plastri Testudinis, Colla cornus cervi are crushed to 24 order coarse powder;
(2), be ground into 120 order fine powders with after the Cortex Cinnamomi drying;
(3) Radix Rehmanniae Preparata, Rhizoma Dioscoreae, Fructus Corni, Fructus Lycii, Semen Cuscutae, the Cortex Eucommiae, Radix Cyathulae, Poria, Radix Angelicae Sinensis are washed one time with clear water, removed dustiness earth, decoct with water secondary.For the first time add 12 times of amounts of water, decocted 2 hours.For the second time add 10 times of amounts of water, decocted 1 hour, merge medical filtration, add Colla Plastri Testudinis and the Cornu Cervi rubber powder pulverized, stir, make its molten dissolve in medicinal liquid, medicinal liquid left standstill 10 hours, got supernatant concentration, be concentrated into relative density 1.10,70 ℃ of temperature get clear paste, drying and crushing to 120 order;
(4) with (2) and (3) powder mixing, under 100 ~ 110 ℃, carried out the ripening sterilization treatment 10～30 minutes, get final product the treatment osteoporosis the powder medicine.
The ripening disinfecting action here is to take ladder type cooling ripening sterilization stage by stage, and temperature is elevated to 110 ℃ rapidly, and segmentation thereafter drops to 100 ℃, and the ripening sterilization time is 10～30 minutes.
Medicine of the present invention can be made the above dosage form of any pharmaceutics.
Powder after the ripening sterilization treatment also can be under gnotobasis, and is in blocks with mechanical compaction, can get tablet.
Powder after the ripening sterilization treatment also can incapsulate with machinery under gnotobasis, can obtain capsule.
An important feature of medicine of the present invention is to contain rich nutrient contents in the medicament.Be principal agent with Colla Plastri Testudinis, Colla cornus cervi in the drug component.Two medicines are the in love product of flesh and blood, and the biological activity degree is high, and Colla Plastri Testudinis contains calcium carbonate 50%, protein 32%.Colla cornus cervi phosphoric acid calcium 50%, and be rich in gonadal hormone estradiol, female alcohol.Two medicines contain various trace elements such as the necessary several amino acids of human bodies such as a large amount of osseins, keratin, glycine, glutamic acid, leucine, arginine, phenylalanine, lysine, methionine, aspartic acid, threonine and magnesium, ferrum, copper, zinc, molybdenum, manganese, cobalt.Cooperate Radix Rehmanniae Preparata, Rhizoma Dioscoreae, Fructus Corni, Fructus Lycii, Semen Cuscutae, the Cortex Eucommiae, Radix Cyathulae liver and kidney tonifying again, fill up marrow, strengthening the tendons and bones.Wherein Colla Plastri Testudinis, Radix Rehmanniae Preparata, Rhizoma Dioscoreae, Fructus Corni, Fructus Lycii again can kidney nourishing waters, fill out kidney yin.
But Colla cornus cervi, Semen Cuscutae, the Cortex Eucommiae, Cortex Cinnamomi the kidney warming sun.But Semen Cuscutae, Cortex Cinnamomi be the warming the spleen sun again, with Rhizoma Dioscoreae, Poria common spleen reinforcing being good for the stomach reinforce spleen and kidney together, improve the ability of digesting and assimilating of taste, essence of water and grain is transported to each is dirty, for skeleton and nutrition of whole body, the Radix Cyathulae promoting blood circulation to restore menstrual flow, the Chinese angelica blood supplementing relieving constipation of invigorating blood circulation, blood arrives to nutrition then, and two medicines help blood circulation, nutrition skeleton and muscle.The Poria diuretic is fated and returns logical water transfer paddy twice, mends logical developing simultaneously, and makes medicine be unlikely to harmony and stagnates.
Whole drug component negative and positive are trained mutually, and YIN and YANG in a relative equilibrium is cold not dry, focuses on liver and kidney tonifying, improves sex hormone level, replenishes biologically actived calcium.Purpose is benefiting essence and marrow, nutrition skeleton, hard bone bone strengthening.
Clinical drug of the present invention uses the result to show that following advantage is arranged:
(1) the present invention's natural animal-plant medicine of selecting the medicated diet homology for use and can be used for health food is a raw material, takes safety, and each component meets the pharmaceutical control law regulation, utilizes the comprehensive function treatment osteoporosis of the Chinese medicine of respectively distinguishing the flavor of.
(2) medicine stability of the present invention is good, and the scale of construction is little, is easy to carry and preserves, and taking convenience does not contain antiseptic, and chemical sweeting agent and sucrose have enlarged scope of medication.
(3) preparation process of the present invention adopts drying and crushing, decoction, molten to fuse, and the spissated way of clear liquid remains unchanged effective ingredient, and operating process is simple, and flow process is orderly, is suitable for large-scale production under the seriality GMP condition.
In order to show the therapeutic effect of medicine of the present invention to osteoporosis, the present invention tests the way that adopts gonadal hormone to measure.This be because: aspect bone metabolism, gonadal hormone has great significance.Gonadal hormone improves bone density to keeping the bone amount, prevents that bone loss from playing an important role; Vitamin D synthetic there is facilitation; Have and promote the Absorption of calcium at enteral.When not enough or obviously low, can cause bone resorption and osteoplastic dysequilibrium when gonadal hormone, because bone resorption is greater than bone formation, bone loss, the osseous tissue micro structure changes, so osteoporosis occurs.
The present invention is through 100 example geratic period (men and women half and half) patient's clinical observations, and selection middle age (men and women half and half) 70 examples are matched group.From being in hospital and endocrine special outpatient clinic selection case.The inactive calcium preparation of test group and other medicine are taken medicine of the present invention, observe three months, and one month is a course of treatment, totally three courses of treatment.Instructions of taking: 2.5 grams/time, day clothes three times, ante cibum, boiled water took.Before taking medicine and take three the course of treatment medicine respectively do the neutral hormone determination of blood, and organize contrast with the middle age.Matched group is refused to obey any medicine, only does the mensuration of sex hormone level in the blood.
Clinical test results such as subordinate list 1-2.
The geratic period male sex hormone changed before and after subordinate list 1 was taken medicine of the present invention
| Case load | Testosterone (ng/dl) | Estradiol (pg/ml) | Testosterone/estradiol | |
| Test group (before taking medicine) | 50 | 468.0±33.7* | 40.2±7.0 | 147.5±30.9 |
| Test group (back of taking medicine) | 50 | 507.7±28.5* | 34.6±4.4 | 189.4±22.6 |
| Matched group (middle age) | 35 | 508.2±29.1 | 35.0±5.2 | 190.3±22.9 |
Annotate: compare * p＜0.01 with the middle age
Geratic period women gonadal hormone changed before and after subordinate list 2 was taken medicine of the present invention
| Case load | Testosterone (ng/dl) | Estradiol (pg/ml) | Testosterone/estradiol | |
| Test group (before taking medicine) | 50 | 46.9±3.2 | 21.2±1.5* | 24.1±0.45 |
| Test group (back of taking medicine) | 50 | 47.7±2.9 | 28.0±3.0* | 28.1±0.46 |
| Matched group (middle age) | 35 | 48.1±3.0 | 28.2±3.1 | 28.2±0.51 |
Annotate: compare * p＜0.01 with the middle age
From subordinate list 1,2 as can be seen,, can significantly improve geratic period man, woman's androgen and estrogen level, make geratic period men and women's androgen and estrogen respectively near middle age man, women androgen and estrogenic level by taking the test of medicine of the present invention.This motherland's medical science kidney governing bones that just coincideing is given birth to marrow.The kidney essense foot, skeleton biochemistry is active, and skeleton obtains bone marrow and nourishes and firm strong theory.Medicine of the present invention is just by invigorating the liver and kidney, and the replenishing essence marrow improves sex hormone level and improves the human body energy metabolism, thereby promotes the formation of bone to realize.
Test statistics shows, takes 100 geratic periods (man, woman half and half) patients with osteoporosis of medicine of the present invention, and that obtains significant curative effect accounts for 72%, effectively accounts for 24%, and invalid accounts for 4%, and total effective rate reaches 96%.
[specific embodiment]
Embodiment one
Weigh raw material by following proportioning:
10 kilograms of 12.8 kilograms of Colla cornus cervis of Colla Plastri Testudinis
10.6 kilograms of 13.9 kilograms of Rhizoma Dioscoreaes of Radix Rehmanniae Preparata
13.3 kilograms of 9.4 kilograms of Fructus Lycii of Fructus Corni
10.6 kilograms of 8.9 kilograms of Cortexs Eucommiae of Semen Cuscutae
10 kilograms in 7.8 kilograms of Poria of Radix Cyathulae
5.6 kilograms of 6.7 kilograms of Cortex Cinnamomis of Radix Angelicae Sinensis
Earlier Colla Plastri Testudinis, Colla cornus cervi are crushed to 24 order coarse powder; With after the Cortex Cinnamomi drying, be ground into 120 order fine powders again; Other gets Radix Rehmanniae Preparata, Rhizoma Dioscoreae, Fructus Corni, Fructus Lycii, Semen Cuscutae, the Cortex Eucommiae, Radix Cyathulae, Poria, Radix Angelicae Sinensis and washes one time with clear water, removes dustiness earth, decocts with water secondary.For the first time add 12 times of amounts of water, decocted 2 hours.For the second time add 10 times of amounts of water, decocted 1 hour, merge medical filtration, add Colla Plastri Testudinis and the Cornu Cervi rubber powder pulverized, stir, make its molten dissolve in medicinal liquid, medicinal liquid left standstill 10 hours, get supernatant concentration, be concentrated into relative density 1.10,70 ℃ of temperature, get clear paste, drying and crushing to 120 order mixes with Cortex Cinnamomi powder, after stirring, be incubated 10 minutes down, and then cool to 105 ℃ of insulations 5 minutes at 110 ℃, reduce to 100 ℃ of insulations 15 minutes then, carry out the ripening sterilization, make powder.Medicine of the present invention is owing to Colla Plastri Testudinis, Colla cornus cervi have been extract, and Cortex Cinnamomi is not because inherent character is done extraction, so yield can reach 38%.Each clothes 2.5 grams of medicine effective quantity of the present invention, every gram is equivalent to primary dose 2.6 grams, obeys every day three times.
Embodiment two
Weigh raw material by following proportioning:
4.4 kilograms of 5 kilograms of Colla cornus cervis of Colla Plastri Testudinis
5 kilograms of 7.8 kilograms of Rhizoma Dioscoreaes of Radix Rehmanniae Preparata
5.6 kilograms of 5.6 kilograms of Fructus Lycii of Fructus Corni
3.8 kilograms of 3.9 kilograms of Cortexs Eucommiae of Semen Cuscutae
4.4 kilograms in 4.4 kilograms of Poria of Radix Cyathulae
3.3 kilograms of 5 kilograms of Cortex Cinnamomis of Radix Angelicae Sinensis
Preparation process is with embodiment one, and different is with the powder after the ripening sterilization, in blocks with mechanical compaction under gnotobasis, can get tablet, yield 37%.Each clothes 2.5 grams of effective dose, every gram is equivalent to primary dose 2.7 grams, obeys every day three times.
Embodiment three
Weigh raw material by following proportioning:
7.5 kilograms of 7.5 kilograms of Colla cornus cervis of Colla Plastri Testudinis
7.5 kilograms of 15 kilograms of Rhizoma Dioscoreaes of Radix Rehmanniae Preparata
7.5 kilograms of 7.5 kilograms of Fructus Lycii of Fructus Corni
7.5 kilograms of 7.5 kilograms of Cortexs Eucommiae of Semen Cuscutae
6.2 kilograms in 6.2 kilograms of Poria of Radix Cyathulae
3.8 kilograms of 6.2 kilograms of Cortex Cinnamomis of Radix Angelicae Sinensis
Preparation process is with embodiment one, and different is with the powder after the ripening sterilization, under gnotobasis, incapsulates with machinery, can get capsule, yield 35%.Each clothes 2.5 grams of effective dose, every gram is equivalent to primary dose 2.9 grams, obeys every day three times.
Claims (8)
1, a kind of medicine for the treatment of osteoporosis is characterized in that it is made by the following weight proportion raw material:
7～20 parts of 8～25 parts of Colla cornus cervis of Colla Plastri Testudinis
8～20 parts of 10～30 portions of Rhizoma Dioscoreaes of Radix Rehmanniae Preparata
8～25 parts of 10～20 parts of Fructus Lycii of Fructus Corni
6～20 parts of 6～20 parts of Cortexs Eucommiae of Semen Cuscutae
6～20 parts in 6～15 parts of Poria of Radix Cyathulae
5～12 parts of 8～15 portions of Cortex Cinnamomis of Radix Angelicae Sinensis.
2, the medicine of treatment osteoporosis according to claim 1, the weight proportion that it is characterized in that making each raw material of medicine is:
12～15 parts of 10～15 parts of Colla cornus cervis of Colla Plastri Testudinis
8～15 parts of 12～25 portions of Rhizoma Dioscoreaes of Radix Rehmanniae Preparata
10～20 parts of 12～15 parts of Fructus Lycii of Fructus Corni
8～15 parts of 8～15 parts of Cortexs Eucommiae of Semen Cuscutae
8～15 parts in 8～12 parts of Poria of Radix Cyathulae
6～10 parts of 8～12 portions of Cortex Cinnamomis of Radix Angelicae Sinensis.
3, the medicine of treatment osteoporosis according to claim 1, the weight proportion that it is characterized in that making each raw material of medicine is:
12 parts of 12 parts of Colla cornus cervis of Colla Plastri Testudinis
12 parts of 24 portions of Rhizoma Dioscoreaes of Radix Rehmanniae Preparata
12 parts of 12 parts of Fructus Lycii of Fructus Corni
12 parts of 12 parts of Cortexs Eucommiae of Semen Cuscutae
10 parts in 10 parts of Poria of Radix Cyathulae
6 parts of 10 portions of Cortex Cinnamomis of Radix Angelicae Sinensis.
4, according to the medicine of claim 1,2 or 3 described treatment osteoporosis, the medicament that it is characterized in that described medicine is the above a dosage form of any pharmaceutics.
5, the medicine of treatment osteoporosis according to claim 4, the medicament that it is characterized in that described medicine are powder, tablet or capsule.
6, a kind of preparation method for preparing the medicine of the above treatment osteoporosis is characterized in that earlier Colla Plastri Testudinis, Colla cornus cervi being crushed to 24 order coarse powder; With after the Cortex Cinnamomi drying, be ground into 120 order fine powders again; Other gets Radix Rehmanniae Preparata, Rhizoma Dioscoreae, Fructus Corni, Fructus Lycii, Semen Cuscutae, the Cortex Eucommiae, Radix Cyathulae, Poria, Radix Angelicae Sinensis is washed one time with clear water, removes dustiness earth, decocts with water secondary, for the first time add 12 times of amounts of water, decocted 2 hours, add 10 times of amounts of water for the second time, decocted 1 hour, merge medical filtration, add Colla Plastri Testudinis and the Cornu Cervi rubber powder pulverized, stir, make its molten dissolve in medicinal liquid, medicinal liquid left standstill 10 hours, got supernatant concentration, was concentrated into relative density 1.10,70 ℃ of temperature, get clear paste, drying and crushing to 120 order mixes with Cortex Cinnamomi powder, after stirring, ripening under 100～110 ℃ of temperature, sterilization was handled 10～30 minutes, made medicine.
7, the preparation method of treatment osteoporosis agents according to claim 6, it is characterized in that the ripening disinfecting action is to adopt ladder type cooling ripening sterilization stage by stage, temperature is elevated to 110 ℃ rapidly, and segmentation drops to 100 ℃ then, and the ripening sterilization time is 10～30 minutes.
8, the preparation method of treatment osteoporosis agents according to claim 7, it is characterized in that the ripening disinfecting action is that the fine powder that will mix is incubated 10 minutes down at 110 ℃, and then cool to 105 ℃ and kept 5 minutes, cool to 100 ℃ again and kept 15 minutes.
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| CNB2006100712251A CN100358559C (en) | 2006-03-20 | 2006-03-20 | Osteoporosis treating medicine and its preparing method |
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| CNB2006100712251A CN100358559C (en) | 2006-03-20 | 2006-03-20 | Osteoporosis treating medicine and its preparing method |
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| CN100358559C CN100358559C (en) | 2008-01-02 |
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Cited By (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN102145106A (en) * | 2011-04-07 | 2011-08-10 | 浙江中医药大学 | Chinese medical composition for treating osteoporosis and granular formulation capable of tonifying kidney and invigorating blood circulation |
| CN103006841A (en) * | 2012-12-07 | 2013-04-03 | 山西医科大学 | Chinese herbal preparation for treating yang-deficiency chronic diarrhea |
| CN103041107A (en) * | 2013-01-14 | 2013-04-17 | 山东省医学科学院基础医学研究所 | Traditional Chinese medicine for preventing estrogen deficiency from causing bone loss and preparation method thereof |
| CN116236535A (en) * | 2023-02-24 | 2023-06-09 | 江西大自然制药有限公司 | Composition for strengthening tendons and bones and preparation method thereof |
Family Cites Families (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1186088C (en) * | 2003-03-17 | 2005-01-26 | 爱新觉罗·恒绍 | Tiegudan for ischemic necrosis of fernoral head |
| CN1241603C (en) * | 2004-03-10 | 2006-02-15 | 李莛岐 | Bone joint disease capsule and its manufacturing metod |
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2006
- 2006-03-20 CN CNB2006100712251A patent/CN100358559C/en not_active Expired - Fee Related
Cited By (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN102145106A (en) * | 2011-04-07 | 2011-08-10 | 浙江中医药大学 | Chinese medical composition for treating osteoporosis and granular formulation capable of tonifying kidney and invigorating blood circulation |
| CN102145106B (en) * | 2011-04-07 | 2012-09-12 | 浙江中医药大学 | Chinese medical composition for treating osteoporosis and granular formulation capable of tonifying kidney and invigorating blood circulation |
| CN103006841A (en) * | 2012-12-07 | 2013-04-03 | 山西医科大学 | Chinese herbal preparation for treating yang-deficiency chronic diarrhea |
| CN103041107A (en) * | 2013-01-14 | 2013-04-17 | 山东省医学科学院基础医学研究所 | Traditional Chinese medicine for preventing estrogen deficiency from causing bone loss and preparation method thereof |
| CN116236535A (en) * | 2023-02-24 | 2023-06-09 | 江西大自然制药有限公司 | Composition for strengthening tendons and bones and preparation method thereof |
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