CN1857333A - Aweto bolus and its preparing method - Google Patents
Aweto bolus and its preparing method Download PDFInfo
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- CN1857333A CN1857333A CN 200610200325 CN200610200325A CN1857333A CN 1857333 A CN1857333 A CN 1857333A CN 200610200325 CN200610200325 CN 200610200325 CN 200610200325 A CN200610200325 A CN 200610200325A CN 1857333 A CN1857333 A CN 1857333A
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- pill
- cordyceps
- bolus
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- aweto
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Abstract
The present invention relates to aweto bolus and its preparation process. The aweto bolus is superior to available liquid aweto preparation, tablet, capsule, etc. and has the advantages of taking convenience, simple preparation process, low production cost, small dosage, high curative effect, etc.
Description
Technical field
The present invention relates to a kind of field of medicaments, particularly relate to aweto bolus and preparation method thereof.
Background technology
Cordyceps full name Cordyceps is China's tradition rare Chinese medicine, mends and not high, warm and not fiery, taste and oiliness drug effect characteristics with being described as China's three big traditional tonic medicines, having with Radix Ginseng, Cornu Cervi Pantotrichum.Because of its unique medical value is described as " kings of hundred medicines ".In before more than 1000 years, " hiding book on Chinese herbal medicine " the medicinal record of Cordyceps is just arranged.Successive dynasties document record, the Cordyceps sweet in the mouth is flat, goes into lung kidney two warps, and lung kidney tonifying, secret lean gas be can protect, the gate of vitality, tonifying deficiency, hemostasis and phlegm mended, chronic cough, it is all good to control diaphragm disease.Modern pharmacy studies confirm that Cordyceps has pharmacological action widely.Because the natural cs growing environment is special, resource-constrained is but overflow, and adopting overflows digs, and causes worm grass resources to face exhaustion.The modern artificial aweto (Cordyceps mycelium) of using to substitute natural cs more, and careless mycelia system natural cs bacterial strain forms through biofermentation, and its main chemical compositions is similar to natural cs with effect, has been widely used in clinical.Cordyceps and ferment cordyceps sinensis mycelium thereof contain 19 seed amino acids such as ucleosides (ribosidoadenine, uridine), cordycepic acid (D one mannitol), ergosterol, Cordyceps polysaccharide and aspartic acid.Also have bioactive ingredients such as multivitamin and trace element in addition.Pharmacology pharmacodynamic discovers that Cordyceps and fermentation mycelium thereof have wide range of therapeutic and health-care effect; has immunological enhancement; protection and therapeutical effect to acute injury of kidney, chronic nephropathy and chronic kidney hypofunction; effect of anti hepatic fibrosis, antiviral and liver protection effect, antibiotic, antiinflammatory action; to cardiovascular effect; hypoglycemic activity, antitumaous effect, multiple effects such as antioxidation, antifatigue effect.Be widely used in kidney diseases such as treatment glomerulonephritis, nephrotic syndrome, IgA nephropathy, acute or chronic renal failure clinically, metabolic disease such as diabetes, hyperlipemia, respiratory system disease such as respiratory tract infection, bronchitis, digestive system disease such as chronic hepatitis, hepatic fibrosis, liver cirrhosis, diseases of cardiovascular and cerebrovascular systems such as heart failure, arrhythmia, coronary heart disease and tumor aid treatment etc.
The pharmacological effect of Cordyceps water extract has carried out extensive studies both at home and abroad, Cordyceps water extract has regulating action to humoral immunization, the Japan scholar studies the immune activation effect of the artificial culture liquid extract (TCKS) of Cordyceps mycelium, finds that the antibody that its mouse oral gives can to strengthen behind the TCKS mouse anti sheep red blood cell (SRBC) (SRBC) produces ability.Further the result of utilization lotus tumor animal pattern research shows, TCKS shows and significantly prolong vital action, think TCKS as with chemotherapeutic agent and be effective with agent.Employing variable concentrations Cordyceps water extracts such as Jia Taiyuan are cultivated with the J774 macrophage, the variation situation of observation of cell activate the phagocytic capacity.The result: cytophagy is active obviously to be strengthened.Prompting enhancing human body immunity function may play an important role in the nourishing and fit keeping function mechanism of action of Cordyceps.The Chinese Academy of Medical Sciences, China Concord Medical Science University's institute of materia medica's primary part observation the influence of Cordyceps water extract to mouse boosting cell T cell subsets and NK cytoactive.Can increase spleen weight, phagocyte number and phagocyte percentage rate through observing Cordyceps.Chou Zhigen etc. have studied the influence of Cordyceps water extract to catabasis and active stage leukemia people NK and LAK cytoactive, found that Cordyceps water extract can strengthen active stage leukemia NK cells of human beings significantly and kill and wound the ability of K562 tumor cell, but the LAK cytoactive is had inhibitory action, and prostaglandin E can be blocked Cordyceps water extract and strengthen the NK cytoactive.Proof Cordyceps water extract strengthens the NK cytoactive has important role in its antineoplastic immune.Zhao Hui etc. studies confirm that Cordyceps and zymophyte powder thereof have tangible antioxidant activity and effect for reducing blood fat, and wherein 70 ℃ of hot water extract's activity are the strongest, and can control atherosis progress by suppressing the LDL lipid peroxidation.
The existing preparation of fermented Cordyceps powder has: oral liquid, tablet, capsule.The deficiency of existing preparation is:
1, oral liquid is a liquid preparation, and the preparation instability easily produces precipitation, and carries, transports inconvenience, the production cost height in the storage.
2, existing tablet, capsule etc. are directly made by former powder, un-extracted, and dose is big, dysphagia, and often cause that the intestines and stomach is unsuitable, make capsule (every 0.2g of specification) once need take the 5-15 grain as hundred.
Pill is the Chinese medicine dosage form, and the kind of pill shared ratio maximum in the Chinese traditional patent formulation preparation has indomitable vitality.Along with quick development of modern science and technology, the improvement of preparation raw material, the use of new excipient and the renewal of method for making etc., pill has had very big development on the basis of inheriting.The pill type is removed traditional watered pill, honeyed pill, water-honeyed pill etc., also has multiple new pill types such as concentrated pill, drop pill, micropill, sugar pill.The pill external form is ball-type or class ball-type, is convenient to take, and has to make simply, the characteristics that production cost is low, it is little that concentrated pill, drop pill, micropill etc. also have a dose, advantages such as good effect, and it is good that sugar pill has mouthfeel in addition, take various informative, can buccal, chew clothes, do not need water advantage such as can take yet, particularly suitable to swallowing inconvenient patient, because the advantage that above-mentioned pill had makes pill be subjected to manufacturing enterprise and patient's popular welcome.
Summary of the invention
The objective of the invention is to overcome liquid preparation instability in the prior art, easily produce precipitation in the storage, carry, transport inconvenience, the deficiency that production cost is high, reach existing tablet, capsule etc. and directly make by former powder, un-extracted, dose is big, dysphagia, and often cause that the intestines and stomach should not wait deficiency, a series of taking conveniences that have are provided, make simple, production cost is low, dose is little, and the pill of advantages such as good effect is to improve the medication compliance, satisfy patient's needs, enrich types of drugs.
The technical solution used in the present invention is:
A kind of aweto bolus is made up of active constituents of medicine Cordyceps and adjuvant.The ratio of Cordyceps and adjuvant is 1-20: 20-1.
Described Cordyceps is one of the two of Cordyceps powder, Cordyceps extract, or any mixture of the two.
Described Cordyceps can be a natural cs, also can be cultural mycelium, as fermented Cordyceps powder (Cs-4), fermented Cordyceps powder (Cs-C-Q80) etc.
Described active constituents of medicine Cordyceps and medically acceptable carrier or excipient are made various pills.Described pill comprises various types of pills, as the watered pill, honeyed pill, water-honeyed pill, concentrated pill, micropill, drop pill, sugar pill etc.
The preparation method of described aweto bolus according to the type and the working condition of made pill, selects suitable conventional preparation method to make ball, can adopt general method for making, moulds method for making, method such as pressing, dropping preparation method is prepared into ball.
But prepared pill coating is coating not also.
Described Cordyceps extract can water be a solvent, adopts suitable method to extract, and can adopt methods such as decocting method, warm macerating method, circumfluence method, ultrasonic extraction to extract.
Described decocting process is for decocting with water each 1-3 hour 2-3 time; Best for decocting with water secondary, 1.5 hours for the first time is 1 hour for the second time.
Described warm macerating technology is for adding 5-10 times of water gaging, warm macerating 2-3 time, each 2-4 hour, temperature 60-90 ℃; Best for adding 7-8 times of water gaging, warm macerating 3 times, each 3 hours, temperature 70-80 ℃.
Described reflux technique is for adding 6-10 times of water gaging, backflow 2-3 time, each 0.5-2 hour; Best for adding 8 times of water gagings, reflux each 1 hour 2 times.
Described aweto bolus can adopt following method to make:
1, get natural cs or fermented Cordyceps powder, be ground into fine powder, with conventional general method for making, mould method for making, pressing is made pill.The heavy 0.1-2.8g of ball.
2, get natural cs or fermented Cordyceps powder, to be ground into fine powder standby for part, and the part water extracts, the extract of gained and above-mentioned fine powder mixing, with the general method for making of routine, mould method for making, pressing is prepared into pill.The heavy 0.1-2.8g of ball.
3, get natural cs or fermented Cordyceps powder, water extracts, the extract of gained with conventional general method for making, mould method for making, pressing, dropping preparation method and make pill.The heavy 0.1-2.8g of ball.
Extracting method can adopt methods such as above-mentioned decocting method, warm macerating method, circumfluence method.
The beneficial effect of aweto bolus of the present invention is mainly reflected in:
1, overcome existing liquid preparation, the preparation instability easily produces precipitation, and carries, transports inconvenience, the deficiency that production cost is high in the storage.
2, overcome existing tablet, capsule etc. and directly made by former powder, un-extracted, dose is big, dysphagia, and often cause the deficiency that the intestines and stomach is unsuitable.
3, described aweto bolus taking convenience, advantage such as processing technology is simple, and production cost is low.
4, prepared Cordyceps concentrated pill dose is little, good effect.
5, prepared Cordyceps sugar pill mouthfeel is good, can buccal, chew clothes, and do not need water can take yet, particularly suitable to swallowing inconvenient patient.
The specific embodiment
Following embodiment is used to further specify the present invention, but does not limit the scope of the invention thus.
Embodiment 1
Get fermented Cordyceps powder, be ground into fine powder, use water pill, drying, promptly.The heavy 0.33g of ball.
Embodiment 2
Get fermented Cordyceps powder, be ground into fine powder, add an amount of refined honey, make plasticity ball piece, pill, drying, promptly.The heavy 0.3g of ball.
Embodiment 3
Get fermented Cordyceps powder, be ground into fine powder, granulate with the 4%PVP alcoholic solution, drying is with 0.3% magnesium stearate mixing, pelleting, promptly.The heavy 0.3g of ball.
Embodiment 4
Prescription: fermented Cordyceps powder 500g
Method for making: get fermented Cordyceps powder (recipe quantity 1/3), be ground into fine powder, standby; Get remaining fermented Cordyceps powder, decoct with water secondary, 1.5 hours for the first time, 1 hour for the second time, filter, filtrate decompression concentrates, and vacuum drying is ground into fine powder, with above-mentioned fine powder mixing, uses 70% alcohol granulation, and drying is pressed into 1000 balls.
Embodiment 5
Prescription: fermented Cordyceps powder 1000g
Method for making: get fermented Cordyceps powder, decoct with water secondary, 1.5 hours for the first time, 1 hour for the second time, filter, filtrate decompression concentrates, and vacuum drying is ground into fine powder, uses water pill, makes 1000 balls.
Embodiment 6
Prescription: fermented Cordyceps powder 1000g
Method for making: get 2/3 fermented Cordyceps powder, decoct with water secondary, 1.5 hours for the first time, 1 hour for the second time, filter, filtrate decompression concentrates, and vacuum drying is ground into fine powder, with remaining 1/3 fermented Cordyceps powder mixing, uses water pill, makes 1000 balls.
Embodiment 7
Prescription: fermented Cordyceps powder 1000g
Method for making: get 2/3 fermented Cordyceps powder, decoct with water secondary, 1.5 hours for the first time, 1 hour for the second time, filter, filtrate decompression concentrates thick paste, with remaining 1/3 fermented Cordyceps powder mixing, makes plasticity ball piece, pill, drying is made 1000 balls.
Embodiment 8
Prescription: fermented Cordyceps powder 1000g magnesium stearate 3g
Method for making: get fermented Cordyceps powder, reflux 2 times, each 1 hour, filter, filtrate decompression concentrates, and vacuum drying is ground into fine powder, granulates, and drying adds magnesium stearate, mixing, pelleting, coating.
Embodiment 9
Prescription: fermented Cordyceps powder 500g polyethylene glycol 6000 400g
Method for making: get fermented Cordyceps powder, 70-80 ℃ of warm macerating three times, each 3 hours, filter, filtrate decompression concentrates, drying, it is standby to be ground into fine powder; Taking polyethylene glycol 6000 heating makes fusion, adds above-mentioned medicated powder, stirs evenly, and remains under 70-90 ℃ the temperature, splashes in the 5-20 ℃ of liquid Paraffin, drains, and makes drop pill.
Embodiment 10
1, prescription
Fermented Cordyceps powder 500g
Icing Sugar 150g
Mannitol 75g
Aspartame 1g
Herba Menthae essence 2g
Magnesium stearate 1g
2, method for making
Get fermented Cordyceps powder and decoct with water secondary, 1.5 hours for the first time, 1 hour for the second time, filter, filtrate decompression concentrates, drying, be ground into fine powder, with Icing Sugar, mannitol, aspartame mixing, granulate drying with 5%PVP ethanol liquid, add Herba Menthae essence, magnesium stearate, mixing is pressed into sugar pill, coating.
Embodiment 11
1, prescription
Fermented Cordyceps powder 500g
Lactose 150g
Amylum pregelatinisatum 50g
Aspartame 1g
Fructus Citri tangerinae essence 2g
2, method for making
Get fermented Cordyceps powder and decoct with water secondary, 1.5 hours for the first time, 1 hour for the second time, filter, filtrate decompression concentrates, and drying is ground into fine powder, with above-mentioned auxiliary materials and mixing, directly is pressed into sugar pill, coating.
Embodiment 12
Prescription: fermented Cordyceps powder 1000g
Method for making: get fermented Cordyceps powder, decoct with water secondary, 1.5 hours for the first time, 1 hour for the second time, filter, filtrate decompression concentrates, and vacuum drying is ground into fine powder, makes micropill, and is encapsulated.
Claims (8)
1. an aweto bolus is made up of active constituents of medicine Cordyceps and adjuvant.
2. the described aweto bolus of claim 1 is characterized in that, the ratio of Cordyceps and adjuvant is 1-20: 20-1.
3. the described aweto bolus of claim 1 is characterized in that, described Cordyceps is one of the two of Cordyceps powder, Cordyceps extract, or any mixture of the two.
4. the described aweto bolus of claim 1 is characterized in that, described Cordyceps can be a natural cs, also can be cultural mycelium, as fermented Cordyceps powder (Cs-4), fermented Cordyceps powder (Cs-C-Q80).
5. the described aweto bolus of claim 1 is characterized in that, active constituents of medicine Cordyceps and medically acceptable carrier or excipient are made various pills.
6. the described aweto bolus of claim 1 is characterized in that, described pill comprises all types of pills, as the watered pill, honeyed pill, water-honeyed pill, concentrated pill, micropill, drop pill, sugar pill etc.
7. the preparation method of the described aweto bolus of claim 1 is characterized in that, according to the type and the working condition of made pill, selects suitable conventional preparation method, as can adopt general method for making, mould method for making, pressing, dropping preparation method etc.
8. the preparation method of the described aweto bolus of claim 1 is characterized in that, can adopt following method:
1, get natural cs or fermented Cordyceps powder, be ground into fine powder, with conventional general method for making, mould method for making, pressing is made pill.
2, get natural cs or fermented Cordyceps powder, to be ground into fine powder standby for part, and the part water extracts, the extract of gained and above-mentioned fine powder mixing, with the general method for making of routine, mould method for making, pressing is prepared into pill.
3, get natural cs or fermented Cordyceps powder, water extracts, the extract of gained with conventional general method for making, mould method for making, pressing, dropping preparation method and make pill.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN 200610200325 CN1857333A (en) | 2006-04-07 | 2006-04-07 | Aweto bolus and its preparing method |
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| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN 200610200325 CN1857333A (en) | 2006-04-07 | 2006-04-07 | Aweto bolus and its preparing method |
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| CN1857333A true CN1857333A (en) | 2006-11-08 |
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Cited By (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN101869337A (en) * | 2010-05-11 | 2010-10-27 | 河南省申氏菇业有限公司 | Pleurotus ferulae and cordyceps mycelium oral solution and production method thereof |
| CN106580897A (en) * | 2016-12-15 | 2017-04-26 | 湖南中健欣元生物科技有限公司 | Cordyceps sinensis wall-broken pellet buccal tablet and preparation method thereof |
| CN106580918A (en) * | 2016-12-15 | 2017-04-26 | 湖南中健欣元生物科技有限公司 | Broken-wall Cordyceps sinensis pellets and preparation method thereof |
-
2006
- 2006-04-07 CN CN 200610200325 patent/CN1857333A/en active Pending
Cited By (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN101869337A (en) * | 2010-05-11 | 2010-10-27 | 河南省申氏菇业有限公司 | Pleurotus ferulae and cordyceps mycelium oral solution and production method thereof |
| CN106580897A (en) * | 2016-12-15 | 2017-04-26 | 湖南中健欣元生物科技有限公司 | Cordyceps sinensis wall-broken pellet buccal tablet and preparation method thereof |
| CN106580918A (en) * | 2016-12-15 | 2017-04-26 | 湖南中健欣元生物科技有限公司 | Broken-wall Cordyceps sinensis pellets and preparation method thereof |
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Open date: 20061108 |