CN1856492A - 咪唑并(4,5－b)吡啶衍生物作为可诱导的no－合酶的抑制剂 - Google Patents

咪唑并(4,5－b)吡啶衍生物作为可诱导的no－合酶的抑制剂 Download PDF

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Publication number
CN1856492A
CN1856492A CNA2004800277964A CN200480027796A CN1856492A CN 1856492 A CN1856492 A CN 1856492A CN A2004800277964 A CNA2004800277964 A CN A2004800277964A CN 200480027796 A CN200480027796 A CN 200480027796A CN 1856492 A CN1856492 A CN 1856492A
Authority
CN
China
Prior art keywords
alkyl
compound
hydrogen
formula
imidazo
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Pending
Application number
CNA2004800277964A
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English (en)
Chinese (zh)
Inventor
R·贝尔
W·-R·乌尔里希
M·埃尔策
D·马克斯
U·格雷德勒
T·福赫斯
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Takeda GmbH
Original Assignee
Altana Pharma AG
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Altana Pharma AG filed Critical Altana Pharma AG
Publication of CN1856492A publication Critical patent/CN1856492A/zh
Pending legal-status Critical Current

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Biomedical Technology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Pain & Pain Management (AREA)
  • Rheumatology (AREA)
  • Communicable Diseases (AREA)
  • Oncology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Plural Heterocyclic Compounds (AREA)
CNA2004800277964A 2003-10-01 2004-09-30 咪唑并(4,5－b)吡啶衍生物作为可诱导的no－合酶的抑制剂 Pending CN1856492A (zh)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
EP03022042 2003-10-01
EP03022042.0 2003-10-01

Publications (1)

Publication Number Publication Date
CN1856492A true CN1856492A (zh) 2006-11-01

Family

ID=34384569

Family Applications (1)

Application Number Title Priority Date Filing Date
CNA2004800277964A Pending CN1856492A (zh) 2003-10-01 2004-09-30 咪唑并(4,5－b)吡啶衍生物作为可诱导的no－合酶的抑制剂

Country Status (16)

Country Link
US (2) US7329677B2 (enExample)
EP (1) EP1675853B1 (enExample)
JP (1) JP2007507463A (enExample)
KR (1) KR20060092221A (enExample)
CN (1) CN1856492A (enExample)
AT (1) ATE398617T1 (enExample)
AU (1) AU2004276012A1 (enExample)
BR (1) BRPI0415038A (enExample)
CA (1) CA2540239A1 (enExample)
DE (1) DE602004014523D1 (enExample)
IL (1) IL173629A0 (enExample)
MX (1) MXPA06003347A (enExample)
NO (1) NO20061343L (enExample)
RS (1) RS20060205A (enExample)
WO (1) WO2005030768A1 (enExample)
ZA (1) ZA200601139B (enExample)

Families Citing this family (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AU2004303515A1 (en) 2003-10-01 2005-07-07 Altana Pharma Ag Aminopyridine-derivatives as inductible no-synthase inhibitors
WO2005030771A1 (en) 2003-10-01 2005-04-07 Altana Pharma Ag Imidazopyridine-derivatives as inductible no-synthase inhibitors
ATE399168T1 (de) 2003-10-01 2008-07-15 Nycomed Gmbh Imidazopyridin-derivate und ihre verwendung als induzierbare no-synthase inhibitoren
KR100863692B1 (ko) * 2006-12-08 2008-10-15 울산대학교 산학협력단 퇴행성질환 및 염증질환에 대한 예방치료 효과를 갖는7-하이드록시-6-메톡시-1,2,3,4-테트라하이드로이소퀴놀린유도체
WO2009029625A1 (en) * 2007-08-27 2009-03-05 Kalypsys, Inc. 4- [heterocyclyl-methyl] -8-fluoro-quinolin-2-ones useful as nitric oxide synthase inhibitors
GB201512635D0 (en) 2015-07-17 2015-08-26 Ucl Business Plc Uses of therapeutic compounds

Family Cites Families (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
SE418966B (sv) * 1974-02-18 1981-07-06 Haessle Ab Analogiforfarande for framstellning av foreningar med magsyrasekretionsinhiberande verkan
US4045564A (en) 1974-02-18 1977-08-30 Ab Hassle Benzimidazole derivatives useful as gastric acid secretion inhibitors
GB8307865D0 (en) * 1983-03-22 1983-04-27 Fujisawa Pharmaceutical Co Benzimidazole derivatives
SE512835C2 (sv) 1996-01-08 2000-05-22 Astrazeneca Ab Doseringsform innehållande en mångfald enheter alla inneslutande syralabil H+K+ATPas-hämmare
AUPP873799A0 (en) 1999-02-17 1999-03-11 Fujisawa Pharmaceutical Co., Ltd. Pyridine compounds
AU2003226706A1 (en) 2002-03-27 2003-10-08 Altana Pharma Ag Novel alkoxypyridine-derivatives
AU2004303515A1 (en) 2003-10-01 2005-07-07 Altana Pharma Ag Aminopyridine-derivatives as inductible no-synthase inhibitors
WO2005030771A1 (en) 2003-10-01 2005-04-07 Altana Pharma Ag Imidazopyridine-derivatives as inductible no-synthase inhibitors
ATE399168T1 (de) 2003-10-01 2008-07-15 Nycomed Gmbh Imidazopyridin-derivate und ihre verwendung als induzierbare no-synthase inhibitoren
EP1673371B1 (en) 2003-10-01 2008-08-06 Nycomed GmbH Imidazopyridine-derivatives as inducible no-synthase inhibitors

Also Published As

Publication number Publication date
MXPA06003347A (es) 2006-06-08
US20080108652A1 (en) 2008-05-08
US20070010549A1 (en) 2007-01-11
AU2004276012A1 (en) 2005-04-07
KR20060092221A (ko) 2006-08-22
WO2005030768A1 (en) 2005-04-07
RS20060205A (sr) 2008-08-07
DE602004014523D1 (de) 2008-07-31
CA2540239A1 (en) 2005-04-07
NO20061343L (no) 2006-03-24
ATE398617T1 (de) 2008-07-15
IL173629A0 (en) 2006-07-05
EP1675853B1 (en) 2008-06-18
US7329677B2 (en) 2008-02-12
EP1675853A1 (en) 2006-07-05
BRPI0415038A (pt) 2006-12-12
ZA200601139B (en) 2007-05-30
JP2007507463A (ja) 2007-03-29

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