CN1852881B - 苯并环庚三烯酚酮衍生物以及炎症反应的调节 - Google Patents

苯并环庚三烯酚酮衍生物以及炎症反应的调节 Download PDF

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CN1852881B
CN1852881B CN2004800270645A CN200480027064A CN1852881B CN 1852881 B CN1852881 B CN 1852881B CN 2004800270645 A CN2004800270645 A CN 2004800270645A CN 200480027064 A CN200480027064 A CN 200480027064A CN 1852881 B CN1852881 B CN 1852881B
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compounds
compound
acetone
theaflavin
gallate
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Expired - Fee Related
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CN2004800270645A
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Chinese (zh)
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CN1852881A (zh
Inventor
何志腾
吉萨·哥亥
桑生民
胡智友
黄谋团
罗伯特·T·罗森
斯莱维克·杜什科夫
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Rutgers, The State University of New Jersey
WellGen Inc
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Rutgers, The State University of New Jersey
WellGen Inc
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C69/00—Esters of carboxylic acids; Esters of carbonic or haloformic acids
    • C07C69/017—Esters of hydroxy compounds having the esterified hydroxy group bound to a carbon atom of a six-membered aromatic ring
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A61P17/18—Antioxidants, e.g. antiradicals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P39/00—General protective or antinoxious agents
    • A61P39/06—Free radical scavengers or antioxidants
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C49/00—Ketones; Ketenes; Dimeric ketenes; Ketonic chelates
    • C07C49/587—Unsaturated compounds containing a keto groups being part of a ring
    • C07C49/703—Unsaturated compounds containing a keto groups being part of a ring containing hydroxy groups
    • C07C49/747—Unsaturated compounds containing a keto groups being part of a ring containing hydroxy groups containing six-membered aromatic rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C49/00—Ketones; Ketenes; Dimeric ketenes; Ketonic chelates
    • C07C49/587—Unsaturated compounds containing a keto groups being part of a ring
    • C07C49/753—Unsaturated compounds containing a keto groups being part of a ring containing ether groups, groups, groups, or groups
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C59/00—Compounds having carboxyl groups bound to acyclic carbon atoms and containing any of the groups OH, O—metal, —CHO, keto, ether, groups, groups, or groups
    • C07C59/40—Unsaturated compounds
    • C07C59/76—Unsaturated compounds containing keto groups
    • C07C59/90—Unsaturated compounds containing keto groups containing singly bound oxygen-containing groups
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C62/00—Compounds having carboxyl groups bound to carbon atoms of rings other than six—membered aromatic rings and containing any of the groups OH, O—metal, —CHO, keto, ether, groups, groups, or groups
    • C07C62/30—Unsaturated compounds
    • C07C62/38—Unsaturated compounds containing keto groups
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C69/00—Esters of carboxylic acids; Esters of carbonic or haloformic acids
    • C07C69/66—Esters of carboxylic acids having esterified carboxylic groups bound to acyclic carbon atoms and having any of the groups OH, O—metal, —CHO, keto, ether, acyloxy, groups, groups, or in the acid moiety
    • C07C69/73—Esters of carboxylic acids having esterified carboxylic groups bound to acyclic carbon atoms and having any of the groups OH, O—metal, —CHO, keto, ether, acyloxy, groups, groups, or in the acid moiety of unsaturated acids
    • C07C69/738—Esters of keto-carboxylic acids or aldehydo-carboxylic acids
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C69/00—Esters of carboxylic acids; Esters of carbonic or haloformic acids
    • C07C69/74—Esters of carboxylic acids having an esterified carboxyl group bound to a carbon atom of a ring other than a six-membered aromatic ring
    • C07C69/757—Esters of carboxylic acids having an esterified carboxyl group bound to a carbon atom of a ring other than a six-membered aromatic ring having any of the groups OH, O—metal, —CHO, keto, ether, acyloxy, groups, groups, or in the acid moiety
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D311/00—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings
    • C07D311/02—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings ortho- or peri-condensed with carbocyclic rings or ring systems
    • C07D311/04—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring
    • C07D311/58—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring other than with oxygen or sulphur atoms in position 2 or 4
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D311/00—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings
    • C07D311/02—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings ortho- or peri-condensed with carbocyclic rings or ring systems
    • C07D311/04—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring
    • C07D311/58—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring other than with oxygen or sulphur atoms in position 2 or 4
    • C07D311/60—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring other than with oxygen or sulphur atoms in position 2 or 4 with aryl radicals attached in position 2
    • C07D311/62—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring other than with oxygen or sulphur atoms in position 2 or 4 with aryl radicals attached in position 2 with oxygen atoms directly attached in position 3, e.g. anthocyanidins
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C2601/00—Systems containing only non-condensed rings
    • C07C2601/12—Systems containing only non-condensed rings with a six-membered ring
    • C07C2601/14—The ring being saturated
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C2602/00—Systems containing two condensed rings
    • C07C2602/02—Systems containing two condensed rings the rings having only two atoms in common
    • C07C2602/04—One of the condensed rings being a six-membered aromatic ring
    • C07C2602/12—One of the condensed rings being a six-membered aromatic ring the other ring being at least seven-membered

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  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Biochemistry (AREA)
  • Toxicology (AREA)
  • Pain & Pain Management (AREA)
  • Rheumatology (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Dermatology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Pyrane Compounds (AREA)
  • Coloring Foods And Improving Nutritive Qualities (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
CN2004800270645A 2003-08-29 2004-08-30 苯并环庚三烯酚酮衍生物以及炎症反应的调节 Expired - Fee Related CN1852881B (zh)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US10/652,813 US7087790B2 (en) 2003-08-29 2003-08-29 Benzotropolone derivatives and modulation of inflammatory response
US10/652,813 2003-08-29
PCT/US2004/028164 WO2005021479A1 (en) 2003-08-29 2004-08-30 Benzotropolone derivatives and modulation of inflammatory response

Publications (2)

Publication Number Publication Date
CN1852881A CN1852881A (zh) 2006-10-25
CN1852881B true CN1852881B (zh) 2010-09-29

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CN2004800270645A Expired - Fee Related CN1852881B (zh) 2003-08-29 2004-08-30 苯并环庚三烯酚酮衍生物以及炎症反应的调节

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US (2) US7087790B2 (enExample)
EP (1) EP1663931B1 (enExample)
JP (1) JP4846581B2 (enExample)
CN (1) CN1852881B (enExample)
CA (1) CA2536842C (enExample)
WO (1) WO2005021479A1 (enExample)

Families Citing this family (19)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US7087790B2 (en) * 2003-08-29 2006-08-08 Rutgers, The State University Of New Jersey Benzotropolone derivatives and modulation of inflammatory response
CA2608651A1 (en) * 2005-05-24 2006-11-30 Wellgen, Inc. Compositions and methods for the prevention and treatment of conditions associated with inflammation
WO2008019985A1 (en) * 2006-08-14 2008-02-21 Unilever Plc Method of purifying theaflavins
EP3238544A1 (en) 2008-03-21 2017-11-01 Rutgers, The State University of New Jersey Use of tea-derived, theaflavin enriched extract to increase exercise performance and reduce exercise recovery time
WO2009156324A2 (en) * 2008-06-25 2009-12-30 Basf Se Use of benzotropolone derivatives as uv absorbers and antioxidants and their use in sunscreens and/or cosmetic compositions
RU2396244C1 (ru) * 2008-12-23 2010-08-10 Тихоокеанский Институт Биоорганической Химии Дальневосточного Отделения Российской Академии Наук (Тибох Дво Ран) Способ получения пурпурогаллина
ES2643463T3 (es) 2009-05-21 2017-11-23 Suntory Holdings Limited Agente antiobesidad que comprende un compuesto que contiene un anillo de benzotropolona
BR112012007685B1 (pt) * 2009-10-06 2024-03-05 Basf Se Uso de derivados de benzotropolona
US8282970B2 (en) * 2009-10-07 2012-10-09 Jiahgsu Dehe Bio-Tech Co., Ltd Theaflavin compositions, related processes and methods of use
US20110082198A1 (en) * 2009-10-07 2011-04-07 Jiangsu Dehe Bio-Tech Co., Ltd. Theaflavin compositions, production, and methods to control physiological disorders in mammals
JP5424424B2 (ja) * 2011-10-03 2014-02-26 国立大学法人 鹿児島大学 抗炎症剤または抗炎症作用を有する飲食品
EP2879669A4 (en) * 2012-07-29 2016-04-13 Univ Colorado Regents ANTAGONISTS OF THE TOLL LIKE RECEPTOR 1/2 COMPLEX
JP2014148530A (ja) * 2014-04-21 2014-08-21 Amazonia Fitomedicamentos Ltda ラノスタ−８，２４−ジエン−３−オールの薬学的使用
JP6628970B2 (ja) * 2015-03-09 2020-01-15 サントリーホールディングス株式会社 ベンゾトロポロン環含有化合物を定量する方法
EP3370523A4 (en) 2015-11-04 2019-12-18 The Penn State Research Foundation CONNECTIONS, COMPOSITIONS AND METHOD FOR COLORING EDIBLE MATERIALS
WO2018096088A1 (en) * 2016-11-24 2018-05-31 Universiteit Antwerpen Halogenated benzotropolones as atg4b inhibitors
WO2020018474A2 (en) 2018-07-16 2020-01-23 Ziegler Gregory Ray Compounds, compositions, and methods for coloring edible materials
CN114869878B (zh) * 2022-04-08 2024-02-23 南通大学 表儿茶素没食子酸酯在制备治疗高原脑水肿药物中的应用
JP2024056384A (ja) * 2022-10-11 2024-04-23 ライオン・スペシャリティ・ケミカルズ株式会社 炎症性因子産生抑制剤

Citations (1)

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Publication number Priority date Publication date Assignee Title
US6113965A (en) * 1997-07-15 2000-09-05 Lipton, Division Of Conopco, Inc. Producing theaflavin

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US3812266A (en) * 1972-01-31 1974-05-21 Lipton T Inc Green tea conversion using tannase and natural tea enzymes
TW381092B (en) 1995-07-07 2000-02-01 Otsuka Pharma Co Ltd Novel benzimidazole derivatives for use in treating arteriosclerotic diseases
US6469053B1 (en) 1996-04-02 2002-10-22 Mars Incorporated Use of procyanidins in the maintenance of vascular health and modulation of the inflammatory response
US5861415A (en) 1996-07-12 1999-01-19 Sami Chemicals & Extracts, Ltd. Bioprotectant composition, method of use and extraction process of curcuminoids
GB9902777D0 (en) * 1999-02-08 1999-03-31 Unilever Plc Cold water infusing leaf tea
CA2383224C (en) 1999-09-21 2010-12-07 Geetha Ghai Extracts of orange peel for prevention and treatment of cancer
US6348224B1 (en) 2000-03-16 2002-02-19 Lipton, Division Of Conopco, Inc. Black tea manufacture
AU2001261004B2 (en) 2000-03-22 2006-07-13 Mars, Incorporated The use of cocoa procyanidins combined with acetylsalicyclic acid as an anti-platelet therapy
JP3694733B2 (ja) 2000-06-29 2005-09-14 独立行政法人農業・生物系特定産業技術研究機構 抗アレルギー剤
US7087790B2 (en) * 2003-08-29 2006-08-08 Rutgers, The State University Of New Jersey Benzotropolone derivatives and modulation of inflammatory response

Patent Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6113965A (en) * 1997-07-15 2000-09-05 Lipton, Division Of Conopco, Inc. Producing theaflavin

Non-Patent Citations (3)

* Cited by examiner, † Cited by third party
Title
Inhibition of 12-O-tetradecanoylphorbol-13-Acetate-InducedInflammatory Skin Edema and Ornithine DecarboxylaseActivity by Theaflavin-3＇3-Digallate in Mouse.Nutrition and Cancer42 2.2002,42(2),218. *
Theadibenzotropolone A,a newtype of pigment fromenzymaticoxidation of (-)-epicatechin and (-)-epigallocatechingallate andcharacterized from black tea usingLC/Mc/MS.tetrahedron letters43.2002,437131. *
TheaflavateB,Isotheaflavin-3＇-o-gallateandneotheaflvvin-3-o-gallate:three polyphenllic pigmentsfromblack tea.Phytochemistry49 8.1998,49(8),2512. *

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US20050049284A1 (en) 2005-03-03
CA2536842A1 (en) 2005-03-10
WO2005021479A1 (en) 2005-03-10
US20060241154A1 (en) 2006-10-26
US7087790B2 (en) 2006-08-08
US7288680B2 (en) 2007-10-30
JP4846581B2 (ja) 2011-12-28
EP1663931A4 (en) 2006-10-18
JP2007504168A (ja) 2007-03-01
EP1663931B1 (en) 2013-04-10
CA2536842C (en) 2014-10-07
CN1852881A (zh) 2006-10-25
EP1663931A1 (en) 2006-06-07

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