CN1852881B - 苯并环庚三烯酚酮衍生物以及炎症反应的调节 - Google Patents

苯并环庚三烯酚酮衍生物以及炎症反应的调节 Download PDF

Info

Publication number
CN1852881B
CN1852881B CN2004800270645A CN200480027064A CN1852881B CN 1852881 B CN1852881 B CN 1852881B CN 2004800270645 A CN2004800270645 A CN 2004800270645A CN 200480027064 A CN200480027064 A CN 200480027064A CN 1852881 B CN1852881 B CN 1852881B
Authority
CN
China
Prior art keywords
compounds
compound
acetone
theaflavin
gallate
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Fee Related
Application number
CN2004800270645A
Other languages
English (en)
Chinese (zh)
Other versions
CN1852881A (zh
Inventor
何志腾
吉萨·哥亥
桑生民
胡智友
黄谋团
罗伯特·T·罗森
斯莱维克·杜什科夫
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Rutgers State University of New Jersey
WellGen Inc
Original Assignee
Rutgers State University of New Jersey
WellGen Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Rutgers State University of New Jersey, WellGen Inc filed Critical Rutgers State University of New Jersey
Publication of CN1852881A publication Critical patent/CN1852881A/zh
Application granted granted Critical
Publication of CN1852881B publication Critical patent/CN1852881B/zh
Anticipated expiration legal-status Critical
Expired - Fee Related legal-status Critical Current

Links

Images

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C69/00—Esters of carboxylic acids; Esters of carbonic or haloformic acids
    • C07C69/017—Esters of hydroxy compounds having the esterified hydroxy group bound to a carbon atom of a six-membered aromatic ring
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A61P17/18—Antioxidants, e.g. antiradicals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P39/00—General protective or antinoxious agents
    • A61P39/06—Free radical scavengers or antioxidants
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C49/00—Ketones; Ketenes; Dimeric ketenes; Ketonic chelates
    • C07C49/587—Unsaturated compounds containing a keto groups being part of a ring
    • C07C49/703—Unsaturated compounds containing a keto groups being part of a ring containing hydroxy groups
    • C07C49/747—Unsaturated compounds containing a keto groups being part of a ring containing hydroxy groups containing six-membered aromatic rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C49/00—Ketones; Ketenes; Dimeric ketenes; Ketonic chelates
    • C07C49/587—Unsaturated compounds containing a keto groups being part of a ring
    • C07C49/753—Unsaturated compounds containing a keto groups being part of a ring containing ether groups, groups, groups, or groups
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C59/00—Compounds having carboxyl groups bound to acyclic carbon atoms and containing any of the groups OH, O—metal, —CHO, keto, ether, groups, groups, or groups
    • C07C59/40—Unsaturated compounds
    • C07C59/76—Unsaturated compounds containing keto groups
    • C07C59/90—Unsaturated compounds containing keto groups containing singly bound oxygen-containing groups
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C62/00—Compounds having carboxyl groups bound to carbon atoms of rings other than six—membered aromatic rings and containing any of the groups OH, O—metal, —CHO, keto, ether, groups, groups, or groups
    • C07C62/30—Unsaturated compounds
    • C07C62/38—Unsaturated compounds containing keto groups
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C69/00—Esters of carboxylic acids; Esters of carbonic or haloformic acids
    • C07C69/66—Esters of carboxylic acids having esterified carboxylic groups bound to acyclic carbon atoms and having any of the groups OH, O—metal, —CHO, keto, ether, acyloxy, groups, groups, or in the acid moiety
    • C07C69/73—Esters of carboxylic acids having esterified carboxylic groups bound to acyclic carbon atoms and having any of the groups OH, O—metal, —CHO, keto, ether, acyloxy, groups, groups, or in the acid moiety of unsaturated acids
    • C07C69/738—Esters of keto-carboxylic acids or aldehydo-carboxylic acids
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C69/00—Esters of carboxylic acids; Esters of carbonic or haloformic acids
    • C07C69/74—Esters of carboxylic acids having an esterified carboxyl group bound to a carbon atom of a ring other than a six-membered aromatic ring
    • C07C69/757—Esters of carboxylic acids having an esterified carboxyl group bound to a carbon atom of a ring other than a six-membered aromatic ring having any of the groups OH, O—metal, —CHO, keto, ether, acyloxy, groups, groups, or in the acid moiety
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D311/00—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings
    • C07D311/02—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings ortho- or peri-condensed with carbocyclic rings or ring systems
    • C07D311/04—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring
    • C07D311/58—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring other than with oxygen or sulphur atoms in position 2 or 4
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D311/00—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings
    • C07D311/02—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings ortho- or peri-condensed with carbocyclic rings or ring systems
    • C07D311/04—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring
    • C07D311/58—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring other than with oxygen or sulphur atoms in position 2 or 4
    • C07D311/60—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring other than with oxygen or sulphur atoms in position 2 or 4 with aryl radicals attached in position 2
    • C07D311/62—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring other than with oxygen or sulphur atoms in position 2 or 4 with aryl radicals attached in position 2 with oxygen atoms directly attached in position 3, e.g. anthocyanidins
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C2601/00—Systems containing only non-condensed rings
    • C07C2601/12—Systems containing only non-condensed rings with a six-membered ring
    • C07C2601/14—The ring being saturated
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C2602/00—Systems containing two condensed rings
    • C07C2602/02—Systems containing two condensed rings the rings having only two atoms in common
    • C07C2602/04—One of the condensed rings being a six-membered aromatic ring
    • C07C2602/12—One of the condensed rings being a six-membered aromatic ring the other ring being at least seven-membered

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Biochemistry (AREA)
  • Toxicology (AREA)
  • Pain & Pain Management (AREA)
  • Rheumatology (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Dermatology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Coloring Foods And Improving Nutritive Qualities (AREA)
  • Pyrane Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
CN2004800270645A 2003-08-29 2004-08-30 苯并环庚三烯酚酮衍生物以及炎症反应的调节 Expired - Fee Related CN1852881B (zh)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US10/652,813 US7087790B2 (en) 2003-08-29 2003-08-29 Benzotropolone derivatives and modulation of inflammatory response
US10/652,813 2003-08-29
PCT/US2004/028164 WO2005021479A1 (en) 2003-08-29 2004-08-30 Benzotropolone derivatives and modulation of inflammatory response

Publications (2)

Publication Number Publication Date
CN1852881A CN1852881A (zh) 2006-10-25
CN1852881B true CN1852881B (zh) 2010-09-29

Family

ID=34217746

Family Applications (1)

Application Number Title Priority Date Filing Date
CN2004800270645A Expired - Fee Related CN1852881B (zh) 2003-08-29 2004-08-30 苯并环庚三烯酚酮衍生物以及炎症反应的调节

Country Status (6)

Country Link
US (2) US7087790B2 (cg-RX-API-DMAC7.html)
EP (1) EP1663931B1 (cg-RX-API-DMAC7.html)
JP (1) JP4846581B2 (cg-RX-API-DMAC7.html)
CN (1) CN1852881B (cg-RX-API-DMAC7.html)
CA (1) CA2536842C (cg-RX-API-DMAC7.html)
WO (1) WO2005021479A1 (cg-RX-API-DMAC7.html)

Families Citing this family (18)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US7087790B2 (en) * 2003-08-29 2006-08-08 Rutgers, The State University Of New Jersey Benzotropolone derivatives and modulation of inflammatory response
AU2006249771A1 (en) * 2005-05-24 2006-11-30 Wellgen, Inc. Compositions and methods for the prevention and treatment of conditions associated with inflammation
WO2008019985A1 (en) * 2006-08-14 2008-02-21 Unilever Plc Method of purifying theaflavins
CN102026552A (zh) 2008-03-21 2011-04-20 罗格斯新泽西州立大学 由茶叶中得到的富含茶黄素的提取物在增加运动功能和减少运动恢复时间中的用途
US9707417B2 (en) * 2008-06-25 2017-07-18 Basf Se Use of benzotropolone derivatives as UV absorbers and antioxidants and their use in sunscreens and/or cosmetic compositions
RU2396244C1 (ru) * 2008-12-23 2010-08-10 Тихоокеанский Институт Биоорганической Химии Дальневосточного Отделения Российской Академии Наук (Тибох Дво Ран) Способ получения пурпурогаллина
NZ596387A (en) * 2009-05-21 2013-07-26 Suntory Holdings Ltd Anti-obesity agent comprising compound containing benzotropolone ring
MX2012003820A (es) * 2009-10-06 2012-05-17 Basf Se Estabilizacion de productos para el hogar, para el cuidado corporal y alimenticios al usar extractos de planta que contienen benzotropolona y/o derivados de benzotropolona relacionados.
US8282970B2 (en) * 2009-10-07 2012-10-09 Jiahgsu Dehe Bio-Tech Co., Ltd Theaflavin compositions, related processes and methods of use
US20110082198A1 (en) * 2009-10-07 2011-04-07 Jiangsu Dehe Bio-Tech Co., Ltd. Theaflavin compositions, production, and methods to control physiological disorders in mammals
JP5424424B2 (ja) * 2011-10-03 2014-02-26 国立大学法人 鹿児島大学 抗炎症剤または抗炎症作用を有する飲食品
WO2014022287A1 (en) * 2012-07-29 2014-02-06 The Regents Of The University Of Colorado, A Body Corporate Antagonists of the toll-like receptor 1/2 complex
JP2014148530A (ja) * 2014-04-21 2014-08-21 Amazonia Fitomedicamentos Ltda ラノスタ−８，２４−ジエン−３−オールの薬学的使用
JP6628970B2 (ja) * 2015-03-09 2020-01-15 サントリーホールディングス株式会社 ベンゾトロポロン環含有化合物を定量する方法
MX2018005614A (es) 2015-11-04 2019-03-14 Penn State Res Found Compuestos, composiciones y metodos para colorear materiales comestibles.
EP3544952B1 (en) * 2016-11-24 2024-11-06 Universiteit Antwerpen Halogenated benzotropolones as atg4b inhibitors
CA3106267A1 (en) 2018-07-16 2020-01-23 Gregory Ray Ziegler Compounds, compositions, and methods for coloring edible materials
CN114869878B (zh) * 2022-04-08 2024-02-23 南通大学 表儿茶素没食子酸酯在制备治疗高原脑水肿药物中的应用

Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6113965A (en) * 1997-07-15 2000-09-05 Lipton, Division Of Conopco, Inc. Producing theaflavin

Family Cites Families (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3812266A (en) * 1972-01-31 1974-05-21 Lipton T Inc Green tea conversion using tannase and natural tea enzymes
TW381092B (en) * 1995-07-07 2000-02-01 Otsuka Pharma Co Ltd Novel benzimidazole derivatives for use in treating arteriosclerotic diseases
US6469053B1 (en) * 1996-04-02 2002-10-22 Mars Incorporated Use of procyanidins in the maintenance of vascular health and modulation of the inflammatory response
US5861415A (en) * 1996-07-12 1999-01-19 Sami Chemicals & Extracts, Ltd. Bioprotectant composition, method of use and extraction process of curcuminoids
GB9902777D0 (en) * 1999-02-08 1999-03-31 Unilever Plc Cold water infusing leaf tea
WO2001021137A1 (en) 1999-09-21 2001-03-29 Rutgers, The State University Extracts of orange peel for prevention and treatment of cancer
US6348224B1 (en) * 2000-03-16 2002-02-19 Lipton, Division Of Conopco, Inc. Black tea manufacture
IL151855A0 (en) * 2000-03-22 2003-04-10 Mars Inc The use of cocoa procyanidins combined with acetylsalicyclic acid as an anti-platelet therapy
JP3694733B2 (ja) * 2000-06-29 2005-09-14 独立行政法人農業・生物系特定産業技術研究機構 抗アレルギー剤
US7087790B2 (en) 2003-08-29 2006-08-08 Rutgers, The State University Of New Jersey Benzotropolone derivatives and modulation of inflammatory response

Patent Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6113965A (en) * 1997-07-15 2000-09-05 Lipton, Division Of Conopco, Inc. Producing theaflavin

Non-Patent Citations (3)

* Cited by examiner, † Cited by third party
Title
Inhibition of 12-O-tetradecanoylphorbol-13-Acetate-InducedInflammatory Skin Edema and Ornithine DecarboxylaseActivity by Theaflavin-3＇3-Digallate in Mouse.Nutrition and Cancer42 2.2002,42(2),218. *
Theadibenzotropolone A,a newtype of pigment fromenzymaticoxidation of (-)-epicatechin and (-)-epigallocatechingallate andcharacterized from black tea usingLC/Mc/MS.tetrahedron letters43.2002,437131. *
TheaflavateB,Isotheaflavin-3＇-o-gallateandneotheaflvvin-3-o-gallate:three polyphenllic pigmentsfromblack tea.Phytochemistry49 8.1998,49(8),2512. *

Also Published As

Publication number Publication date
JP2007504168A (ja) 2007-03-01
US20060241154A1 (en) 2006-10-26
CA2536842A1 (en) 2005-03-10
US20050049284A1 (en) 2005-03-03
WO2005021479A1 (en) 2005-03-10
US7087790B2 (en) 2006-08-08
CA2536842C (en) 2014-10-07
CN1852881A (zh) 2006-10-25
EP1663931B1 (en) 2013-04-10
EP1663931A4 (en) 2006-10-18
JP4846581B2 (ja) 2011-12-28
US7288680B2 (en) 2007-10-30
EP1663931A1 (en) 2006-06-07

Similar Documents

Publication Publication Date Title
CN1852881B (zh) 苯并环庚三烯酚酮衍生物以及炎症反应的调节
US9408824B2 (en) Compositions and products containing S-equol, and methods for their making
Landete et al. Bioactivation of phytoestrogens: intestinal bacteria and health
US7799955B2 (en) Isoflavone metabolites
US20120101152A1 (en) Neurite elongation agent, memory-improving agent and anti-alzheimer agent comprising 4'-demethylnobiletin or 4'-demethyltangeretin as active ingredient, and process for production of the compound
KR100257448B1 (ko) 항암, 기관분화유도, 암세포전이 혈관형성억제, 항산화 및 숙취해소 작용을 하는 옻나무 추출물, 이의 제조방법 및 이를 포함하는 조성물
MC1254A1 (fr) Preparation d'agents antiviraux et de formules pharmaceutiques de ces agents
CN102670571B (zh) 预防和治疗心血管疾病的喹啉化合物，以及含有蜈蚣提取物或从提取物中分离的化合物的组合物
TWI353847B (en) Sulfur-containing proanthocyanidin oligomer compos
KR20150144370A (ko) 오디 유래 아릴벤조퓨란 및 플라보노이드 화합물을 포함하는 퇴행성 뇌질환의 예방, 개선 및 치료용 조성물
HK1153911A (en) Compositions and products containing enantiomeric equol, and their use

Legal Events

Date Code Title Description
C06 Publication
PB01 Publication
C10 Entry into substantive examination
SE01 Entry into force of request for substantive examination
C14 Grant of patent or utility model
GR01 Patent grant
C17 Cessation of patent right
CF01 Termination of patent right due to non-payment of annual fee

Granted publication date: 20100929

Termination date: 20130830