CN1852697B - 卤代羟基二苯基醚化合物在皮肤处理中的应用 - Google Patents
卤代羟基二苯基醚化合物在皮肤处理中的应用 Download PDFInfo
- Publication number
- CN1852697B CN1852697B CN2004800264517A CN200480026451A CN1852697B CN 1852697 B CN1852697 B CN 1852697B CN 2004800264517 A CN2004800264517 A CN 2004800264517A CN 200480026451 A CN200480026451 A CN 200480026451A CN 1852697 B CN1852697 B CN 1852697B
- Authority
- CN
- China
- Prior art keywords
- sub
- alkyl
- acid
- purposes
- formula
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Fee Related
Links
- 150000002170 ethers Chemical class 0.000 title abstract 2
- 229910052739 hydrogen Inorganic materials 0.000 claims abstract description 42
- 239000001257 hydrogen Substances 0.000 claims abstract description 39
- UFHFLCQGNIYNRP-UHFFFAOYSA-N Hydrogen Chemical compound [H][H] UFHFLCQGNIYNRP-UHFFFAOYSA-N 0.000 claims abstract description 17
- 150000002431 hydrogen Chemical class 0.000 claims abstract description 16
- 239000003112 inhibitor Substances 0.000 claims abstract description 11
- 230000003061 melanogenesis Effects 0.000 claims abstract description 6
- -1 ester compounds Chemical class 0.000 claims description 144
- 239000000203 mixture Substances 0.000 claims description 93
- 150000001875 compounds Chemical class 0.000 claims description 64
- RTZKZFJDLAIYFH-UHFFFAOYSA-N ether Substances CCOCC RTZKZFJDLAIYFH-UHFFFAOYSA-N 0.000 claims description 39
- 239000000463 material Substances 0.000 claims description 28
- 239000002250 absorbent Substances 0.000 claims description 20
- 230000002745 absorbent Effects 0.000 claims description 20
- 125000002496 methyl group Chemical group [H]C([H])([H])* 0.000 claims description 15
- 239000008406 cosmetic ingredient Substances 0.000 claims description 12
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims description 11
- REFJWTPEDVJJIY-UHFFFAOYSA-N Quercetin Chemical compound C=1C(O)=CC(O)=C(C(C=2O)=O)C=1OC=2C1=CC=C(O)C(O)=C1 REFJWTPEDVJJIY-UHFFFAOYSA-N 0.000 claims description 10
- 206010040829 Skin discolouration Diseases 0.000 claims description 10
- BDJRBEYXGGNYIS-UHFFFAOYSA-N nonanedioic acid Chemical compound OC(=O)CCCCCCCC(O)=O BDJRBEYXGGNYIS-UHFFFAOYSA-N 0.000 claims description 10
- 239000006081 fluorescent whitening agent Substances 0.000 claims description 9
- 229960004705 kojic acid Drugs 0.000 claims description 9
- WZNJWVWKTVETCG-UHFFFAOYSA-N kojic acid Natural products OC(=O)C(N)CN1C=CC(=O)C(O)=C1 WZNJWVWKTVETCG-UHFFFAOYSA-N 0.000 claims description 9
- 150000001768 cations Chemical class 0.000 claims description 8
- BEJNERDRQOWKJM-UHFFFAOYSA-N kojic acid Chemical compound OCC1=CC(=O)C(O)=CO1 BEJNERDRQOWKJM-UHFFFAOYSA-N 0.000 claims description 8
- 239000002904 solvent Substances 0.000 claims description 8
- 230000000845 anti-microbial effect Effects 0.000 claims description 7
- BJRNKVDFDLYUGJ-RMPHRYRLSA-N hydroquinone O-beta-D-glucopyranoside Chemical compound O[C@@H]1[C@@H](O)[C@H](O)[C@@H](CO)O[C@H]1OC1=CC=C(O)C=C1 BJRNKVDFDLYUGJ-RMPHRYRLSA-N 0.000 claims description 7
- HKIKAXXIWJHWLY-ZIIYPAMZSA-N Aloesin Chemical compound C=12OC(CC(=O)C)=CC(=O)C2=C(C)C=C(O)C=1[C@@H]1O[C@H](CO)[C@@H](O)[C@H](O)[C@H]1O HKIKAXXIWJHWLY-ZIIYPAMZSA-N 0.000 claims description 6
- HKIKAXXIWJHWLY-QEVGBQTESA-N Aloesin Natural products O=C(CC=1Oc2c([C@H]3[C@H](O)[C@@H](O)[C@@H](O)[C@@H](CO)O3)c(O)cc(C)c2C(=O)C=1)C HKIKAXXIWJHWLY-QEVGBQTESA-N 0.000 claims description 6
- AFSDNFLWKVMVRB-UHFFFAOYSA-N Ellagic acid Chemical compound OC1=C(O)C(OC2=O)=C3C4=C2C=C(O)C(O)=C4OC(=O)C3=C1 AFSDNFLWKVMVRB-UHFFFAOYSA-N 0.000 claims description 6
- ATJXMQHAMYVHRX-CPCISQLKSA-N Ellagic acid Natural products OC1=C(O)[C@H]2OC(=O)c3cc(O)c(O)c4OC(=O)C(=C1)[C@H]2c34 ATJXMQHAMYVHRX-CPCISQLKSA-N 0.000 claims description 6
- 229920002079 Ellagic acid Polymers 0.000 claims description 6
- TWVJWDMOZJXUID-SDDRHHMPSA-N Guaiol Chemical compound C1([C@H](CC[C@H](C2)C(C)(C)O)C)=C2[C@@H](C)CC1 TWVJWDMOZJXUID-SDDRHHMPSA-N 0.000 claims description 6
- 239000000460 chlorine Substances 0.000 claims description 6
- 229960002852 ellagic acid Drugs 0.000 claims description 6
- 235000004132 ellagic acid Nutrition 0.000 claims description 6
- TWVJWDMOZJXUID-QJPTWQEYSA-N guaiol Natural products OC(C)(C)[C@H]1CC=2[C@H](C)CCC=2[C@@H](C)CC1 TWVJWDMOZJXUID-QJPTWQEYSA-N 0.000 claims description 6
- FAARLWTXUUQFSN-UHFFFAOYSA-N methylellagic acid Natural products O1C(=O)C2=CC(O)=C(O)C3=C2C2=C1C(OC)=C(O)C=C2C(=O)O3 FAARLWTXUUQFSN-UHFFFAOYSA-N 0.000 claims description 6
- ZAMOUSCENKQFHK-UHFFFAOYSA-N Chlorine atom Chemical compound [Cl] ZAMOUSCENKQFHK-UHFFFAOYSA-N 0.000 claims description 5
- ZVOLCUVKHLEPEV-UHFFFAOYSA-N Quercetagetin Natural products C1=C(O)C(O)=CC=C1C1=C(O)C(=O)C2=C(O)C(O)=C(O)C=C2O1 ZVOLCUVKHLEPEV-UHFFFAOYSA-N 0.000 claims description 5
- HWTZYBCRDDUBJY-UHFFFAOYSA-N Rhynchosin Natural products C1=C(O)C(O)=CC=C1C1=C(O)C(=O)C2=CC(O)=C(O)C=C2O1 HWTZYBCRDDUBJY-UHFFFAOYSA-N 0.000 claims description 5
- 229910052801 chlorine Inorganic materials 0.000 claims description 5
- MWDZOUNAPSSOEL-UHFFFAOYSA-N kaempferol Natural products OC1=C(C(=O)c2cc(O)cc(O)c2O1)c3ccc(O)cc3 MWDZOUNAPSSOEL-UHFFFAOYSA-N 0.000 claims description 5
- 235000005875 quercetin Nutrition 0.000 claims description 5
- 229960001285 quercetin Drugs 0.000 claims description 5
- YBGZDTIWKVFICR-JLHYYAGUSA-N Octyl 4-methoxycinnamic acid Chemical compound CCCCC(CC)COC(=O)\C=C\C1=CC=C(OC)C=C1 YBGZDTIWKVFICR-JLHYYAGUSA-N 0.000 claims description 4
- 229910052751 metal Inorganic materials 0.000 claims description 4
- 239000002184 metal Substances 0.000 claims description 4
- DXGLGDHPHMLXJC-UHFFFAOYSA-N oxybenzone Chemical compound OC1=CC(OC)=CC=C1C(=O)C1=CC=CC=C1 DXGLGDHPHMLXJC-UHFFFAOYSA-N 0.000 claims description 4
- 210000004877 mucosa Anatomy 0.000 claims description 3
- 229960001679 octinoxate Drugs 0.000 claims description 3
- 229960001173 oxybenzone Drugs 0.000 claims description 3
- 229960000271 arbutin Drugs 0.000 claims description 2
- BJRNKVDFDLYUGJ-UHFFFAOYSA-N p-hydroxyphenyl beta-D-alloside Natural products OC1C(O)C(O)C(CO)OC1OC1=CC=C(O)C=C1 BJRNKVDFDLYUGJ-UHFFFAOYSA-N 0.000 claims description 2
- 125000000217 alkyl group Chemical group 0.000 abstract description 34
- 125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 abstract description 7
- 125000002887 hydroxy group Chemical group [H]O* 0.000 abstract description 4
- 125000003545 alkoxy group Chemical group 0.000 abstract description 3
- 125000003178 carboxy group Chemical group [H]OC(*)=O 0.000 abstract description 3
- 125000004448 alkyl carbonyl group Chemical group 0.000 abstract 3
- 125000000753 cycloalkyl group Chemical group 0.000 abstract 2
- 125000003903 2-propenyl group Chemical group [H]C([*])([H])C([H])=C([H])[H] 0.000 abstract 1
- 125000001539 acetonyl group Chemical group [H]C([H])([H])C(=O)C([H])([H])* 0.000 abstract 1
- 125000003342 alkenyl group Chemical group 0.000 abstract 1
- 125000002485 formyl group Chemical group [H]C(*)=O 0.000 abstract 1
- 150000002148 esters Chemical class 0.000 description 49
- 239000000194 fatty acid Substances 0.000 description 46
- 235000014113 dietary fatty acids Nutrition 0.000 description 40
- 229930195729 fatty acid Natural products 0.000 description 40
- 239000000344 soap Substances 0.000 description 37
- 229910052799 carbon Inorganic materials 0.000 description 36
- 238000002360 preparation method Methods 0.000 description 35
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 description 33
- 241001597008 Nomeidae Species 0.000 description 32
- 150000001721 carbon Chemical group 0.000 description 32
- 150000004665 fatty acids Chemical class 0.000 description 31
- PEDCQBHIVMGVHV-UHFFFAOYSA-N glycerol Substances OCC(O)CO PEDCQBHIVMGVHV-UHFFFAOYSA-N 0.000 description 31
- 239000003921 oil Substances 0.000 description 29
- 235000019198 oils Nutrition 0.000 description 28
- 239000002585 base Substances 0.000 description 25
- 150000003839 salts Chemical class 0.000 description 20
- 229910052760 oxygen Inorganic materials 0.000 description 19
- KRKNYBCHXYNGOX-UHFFFAOYSA-N citric acid Chemical compound OC(=O)CC(O)(C(O)=O)CC(O)=O KRKNYBCHXYNGOX-UHFFFAOYSA-N 0.000 description 18
- 239000002537 cosmetic Substances 0.000 description 18
- 239000000047 product Substances 0.000 description 17
- 239000002253 acid Substances 0.000 description 16
- DNIAPMSPPWPWGF-UHFFFAOYSA-N Propylene glycol Chemical compound CC(O)CO DNIAPMSPPWPWGF-UHFFFAOYSA-N 0.000 description 15
- 125000003118 aryl group Chemical group 0.000 description 15
- 239000000126 substance Substances 0.000 description 15
- DNIAPMSPPWPWGF-GSVOUGTGSA-N (R)-(-)-Propylene glycol Chemical compound C[C@@H](O)CO DNIAPMSPPWPWGF-GSVOUGTGSA-N 0.000 description 14
- 239000003963 antioxidant agent Substances 0.000 description 14
- 230000003078 antioxidant effect Effects 0.000 description 14
- 235000006708 antioxidants Nutrition 0.000 description 14
- 150000005846 sugar alcohols Polymers 0.000 description 14
- 239000007788 liquid Substances 0.000 description 13
- 239000006210 lotion Substances 0.000 description 13
- ATUOYWHBWRKTHZ-UHFFFAOYSA-N Propane Chemical compound CCC ATUOYWHBWRKTHZ-UHFFFAOYSA-N 0.000 description 12
- IAYPIBMASNFSPL-UHFFFAOYSA-N Ethylene oxide Chemical compound C1CO1 IAYPIBMASNFSPL-UHFFFAOYSA-N 0.000 description 11
- 230000000694 effects Effects 0.000 description 11
- FIDRAVVQGKNYQK-UHFFFAOYSA-N 1,2,3,4-tetrahydrotriazine Chemical compound C1NNNC=C1 FIDRAVVQGKNYQK-UHFFFAOYSA-N 0.000 description 10
- LYCAIKOWRPUZTN-UHFFFAOYSA-N Ethylene glycol Chemical compound OCCO LYCAIKOWRPUZTN-UHFFFAOYSA-N 0.000 description 10
- 239000007859 condensation product Substances 0.000 description 10
- 239000006071 cream Substances 0.000 description 10
- 239000003995 emulsifying agent Substances 0.000 description 10
- 235000019197 fats Nutrition 0.000 description 10
- 235000011187 glycerol Nutrition 0.000 description 10
- 239000004094 surface-active agent Substances 0.000 description 10
- KFZMGEQAYNKOFK-UHFFFAOYSA-N Isopropanol Chemical compound CC(C)O KFZMGEQAYNKOFK-UHFFFAOYSA-N 0.000 description 9
- WPYMKLBDIGXBTP-UHFFFAOYSA-N benzoic acid Chemical compound OC(=O)C1=CC=CC=C1 WPYMKLBDIGXBTP-UHFFFAOYSA-N 0.000 description 9
- 229920001577 copolymer Polymers 0.000 description 9
- USIUVYZYUHIAEV-UHFFFAOYSA-N diphenyl ether Natural products C=1C=CC=CC=1OC1=CC=CC=C1 USIUVYZYUHIAEV-UHFFFAOYSA-N 0.000 description 9
- 238000009472 formulation Methods 0.000 description 9
- 239000007787 solid Substances 0.000 description 9
- QTBSBXVTEAMEQO-UHFFFAOYSA-N Acetic acid Chemical compound CC(O)=O QTBSBXVTEAMEQO-UHFFFAOYSA-N 0.000 description 8
- CIWBSHSKHKDKBQ-JLAZNSOCSA-N Ascorbic acid Chemical compound OC[C@H](O)[C@H]1OC(=O)C(O)=C1O CIWBSHSKHKDKBQ-JLAZNSOCSA-N 0.000 description 8
- QAOWNCQODCNURD-UHFFFAOYSA-L Sulfate Chemical compound [O-]S([O-])(=O)=O QAOWNCQODCNURD-UHFFFAOYSA-L 0.000 description 8
- 239000003795 chemical substances by application Substances 0.000 description 8
- 239000000839 emulsion Substances 0.000 description 8
- 125000001495 ethyl group Chemical group [H]C([H])([H])C([H])([H])* 0.000 description 8
- 239000000499 gel Substances 0.000 description 8
- QIQXTHQIDYTFRH-UHFFFAOYSA-N octadecanoic acid Chemical compound CCCCCCCCCCCCCCCCCC(O)=O QIQXTHQIDYTFRH-UHFFFAOYSA-N 0.000 description 8
- 235000013162 Cocos nucifera Nutrition 0.000 description 7
- 244000060011 Cocos nucifera Species 0.000 description 7
- DHMQDGOQFOQNFH-UHFFFAOYSA-N Glycine Chemical compound NCC(O)=O DHMQDGOQFOQNFH-UHFFFAOYSA-N 0.000 description 7
- ISWSIDIOOBJBQZ-UHFFFAOYSA-N Phenol Chemical compound OC1=CC=CC=C1 ISWSIDIOOBJBQZ-UHFFFAOYSA-N 0.000 description 7
- 229910052783 alkali metal Inorganic materials 0.000 description 7
- XAGFODPZIPBFFR-UHFFFAOYSA-N aluminium Chemical compound [Al] XAGFODPZIPBFFR-UHFFFAOYSA-N 0.000 description 7
- 150000001412 amines Chemical class 0.000 description 7
- 239000001301 oxygen Substances 0.000 description 7
- 239000001294 propane Substances 0.000 description 7
- 229910052708 sodium Inorganic materials 0.000 description 7
- 239000011734 sodium Chemical group 0.000 description 7
- 238000005507 spraying Methods 0.000 description 7
- 239000000516 sunscreening agent Substances 0.000 description 7
- 239000001993 wax Substances 0.000 description 7
- LQJBNNIYVWPHFW-UHFFFAOYSA-N 20:1omega9c fatty acid Natural products CCCCCCCCCCC=CCCCCCCCC(O)=O LQJBNNIYVWPHFW-UHFFFAOYSA-N 0.000 description 6
- DGAQECJNVWCQMB-PUAWFVPOSA-M Ilexoside XXIX Chemical compound C[C@@H]1CC[C@@]2(CC[C@@]3(C(=CC[C@H]4[C@]3(CC[C@@H]5[C@@]4(CC[C@@H](C5(C)C)OS(=O)(=O)[O-])C)C)[C@@H]2[C@]1(C)O)C)C(=O)O[C@H]6[C@@H]([C@H]([C@@H]([C@H](O6)CO)O)O)O.[Na+] DGAQECJNVWCQMB-PUAWFVPOSA-M 0.000 description 6
- ZQPPMHVWECSIRJ-UHFFFAOYSA-N Oleic acid Natural products CCCCCCCCC=CCCCCCCCC(O)=O ZQPPMHVWECSIRJ-UHFFFAOYSA-N 0.000 description 6
- 229910019142 PO4 Inorganic materials 0.000 description 6
- 235000021355 Stearic acid Nutrition 0.000 description 6
- WNLRTRBMVRJNCN-UHFFFAOYSA-N adipic acid Chemical compound OC(=O)CCCCC(O)=O WNLRTRBMVRJNCN-UHFFFAOYSA-N 0.000 description 6
- 239000002671 adjuvant Substances 0.000 description 6
- 150000001299 aldehydes Chemical class 0.000 description 6
- POJWUDADGALRAB-UHFFFAOYSA-N allantoin Chemical compound NC(=O)NC1NC(=O)NC1=O POJWUDADGALRAB-UHFFFAOYSA-N 0.000 description 6
- 229910052782 aluminium Inorganic materials 0.000 description 6
- CUFNKYGDVFVPHO-UHFFFAOYSA-N azulene Chemical compound C1=CC=CC2=CC=CC2=C1 CUFNKYGDVFVPHO-UHFFFAOYSA-N 0.000 description 6
- 235000015165 citric acid Nutrition 0.000 description 6
- 238000004140 cleaning Methods 0.000 description 6
- MTHSVFCYNBDYFN-UHFFFAOYSA-N diethylene glycol Chemical compound OCCOCCO MTHSVFCYNBDYFN-UHFFFAOYSA-N 0.000 description 6
- 239000004615 ingredient Substances 0.000 description 6
- QXJSBBXBKPUZAA-UHFFFAOYSA-N isooleic acid Natural products CCCCCCCC=CCCCCCCCCC(O)=O QXJSBBXBKPUZAA-UHFFFAOYSA-N 0.000 description 6
- JVTAAEKCZFNVCJ-UHFFFAOYSA-N lactic acid Chemical compound CC(O)C(O)=O JVTAAEKCZFNVCJ-UHFFFAOYSA-N 0.000 description 6
- OQCDKBAXFALNLD-UHFFFAOYSA-N octadecanoic acid Natural products CCCCCCCC(C)CCCCCCCCC(O)=O OQCDKBAXFALNLD-UHFFFAOYSA-N 0.000 description 6
- 239000010452 phosphate Substances 0.000 description 6
- 239000000843 powder Substances 0.000 description 6
- 108090000765 processed proteins & peptides Proteins 0.000 description 6
- 239000008117 stearic acid Substances 0.000 description 6
- 230000000475 sunscreen effect Effects 0.000 description 6
- 239000000271 synthetic detergent Substances 0.000 description 6
- 125000000999 tert-butyl group Chemical group [H]C([H])([H])C(*)(C([H])([H])[H])C([H])([H])[H] 0.000 description 6
- WRIDQFICGBMAFQ-UHFFFAOYSA-N (E)-8-Octadecenoic acid Natural products CCCCCCCCCC=CCCCCCCC(O)=O WRIDQFICGBMAFQ-UHFFFAOYSA-N 0.000 description 5
- QSBYPNXLFMSGKH-UHFFFAOYSA-N 9-Heptadecensaeure Natural products CCCCCCCC=CCCCCCCCC(O)=O QSBYPNXLFMSGKH-UHFFFAOYSA-N 0.000 description 5
- QGZKDVFQNNGYKY-UHFFFAOYSA-O Ammonium Chemical compound [NH4+] QGZKDVFQNNGYKY-UHFFFAOYSA-O 0.000 description 5
- FBPFZTCFMRRESA-JGWLITMVSA-N D-glucitol Chemical compound OC[C@H](O)[C@@H](O)[C@H](O)[C@H](O)CO FBPFZTCFMRRESA-JGWLITMVSA-N 0.000 description 5
- WQZGKKKJIJFFOK-GASJEMHNSA-N Glucose Natural products OC[C@H]1OC(O)[C@H](O)[C@@H](O)[C@@H]1O WQZGKKKJIJFFOK-GASJEMHNSA-N 0.000 description 5
- QIGBRXMKCJKVMJ-UHFFFAOYSA-N Hydroquinone Chemical compound OC1=CC=C(O)C=C1 QIGBRXMKCJKVMJ-UHFFFAOYSA-N 0.000 description 5
- 239000005642 Oleic acid Substances 0.000 description 5
- GWEVSGVZZGPLCZ-UHFFFAOYSA-N Titan oxide Chemical compound O=[Ti]=O GWEVSGVZZGPLCZ-UHFFFAOYSA-N 0.000 description 5
- 150000001340 alkali metals Chemical class 0.000 description 5
- 239000002280 amphoteric surfactant Substances 0.000 description 5
- 239000003213 antiperspirant Substances 0.000 description 5
- 239000001654 beetroot red Substances 0.000 description 5
- 239000002781 deodorant agent Substances 0.000 description 5
- 239000006260 foam Substances 0.000 description 5
- DKAGJZJALZXOOV-UHFFFAOYSA-N hydrate;hydrochloride Chemical compound O.Cl DKAGJZJALZXOOV-UHFFFAOYSA-N 0.000 description 5
- 238000002156 mixing Methods 0.000 description 5
- 125000001436 propyl group Chemical group [H]C([*])([H])C([H])([H])C([H])([H])[H] 0.000 description 5
- YGSDEFSMJLZEOE-UHFFFAOYSA-N salicylic acid Chemical class OC(=O)C1=CC=CC=C1O YGSDEFSMJLZEOE-UHFFFAOYSA-N 0.000 description 5
- ULQISTXYYBZJSJ-UHFFFAOYSA-N 12-hydroxyoctadecanoic acid Chemical compound CCCCCCC(O)CCCCCCCCCCC(O)=O ULQISTXYYBZJSJ-UHFFFAOYSA-N 0.000 description 4
- XDOFQFKRPWOURC-UHFFFAOYSA-N 16-methylheptadecanoic acid Chemical class CC(C)CCCCCCCCCCCCCCC(O)=O XDOFQFKRPWOURC-UHFFFAOYSA-N 0.000 description 4
- 241000894006 Bacteria Species 0.000 description 4
- 239000005711 Benzoic acid Substances 0.000 description 4
- DHHFDKNIEVKVKS-FMOSSLLZSA-N Betanin Chemical compound O[C@@H]1[C@@H](O)[C@H](O)[C@@H](CO)O[C@H]1OC(C(=C1)O)=CC(C[C@H]2C([O-])=O)=C1[N+]2=C\C=C\1C=C(C(O)=O)N[C@H](C(O)=O)C/1 DHHFDKNIEVKVKS-FMOSSLLZSA-N 0.000 description 4
- DHHFDKNIEVKVKS-MVUYWVKGSA-N Betanin Natural products O=C(O)[C@@H]1NC(C(=O)O)=C/C(=C\C=[N+]/2\[C@@H](C(=O)[O-])Cc3c\2cc(O)c(O[C@H]2[C@H](O)[C@@H](O)[C@H](O)[C@@H](CO)O2)c3)/C1 DHHFDKNIEVKVKS-MVUYWVKGSA-N 0.000 description 4
- WKBOTKDWSSQWDR-UHFFFAOYSA-N Bromine atom Chemical compound [Br] WKBOTKDWSSQWDR-UHFFFAOYSA-N 0.000 description 4
- OKTJSMMVPCPJKN-UHFFFAOYSA-N Carbon Chemical compound [C] OKTJSMMVPCPJKN-UHFFFAOYSA-N 0.000 description 4
- GLZPCOQZEFWAFX-UHFFFAOYSA-N Geraniol Chemical compound CC(C)=CCCC(C)=CCO GLZPCOQZEFWAFX-UHFFFAOYSA-N 0.000 description 4
- 239000004471 Glycine Substances 0.000 description 4
- 208000003351 Melanosis Diseases 0.000 description 4
- WHNWPMSKXPGLAX-UHFFFAOYSA-N N-Vinyl-2-pyrrolidone Chemical compound C=CN1CCCC1=O WHNWPMSKXPGLAX-UHFFFAOYSA-N 0.000 description 4
- 239000002202 Polyethylene glycol Substances 0.000 description 4
- OFOBLEOULBTSOW-UHFFFAOYSA-N Propanedioic acid Natural products OC(=O)CC(O)=O OFOBLEOULBTSOW-UHFFFAOYSA-N 0.000 description 4
- PPBRXRYQALVLMV-UHFFFAOYSA-N Styrene Chemical compound C=CC1=CC=CC=C1 PPBRXRYQALVLMV-UHFFFAOYSA-N 0.000 description 4
- XSQUKJJJFZCRTK-UHFFFAOYSA-N Urea Chemical compound NC(N)=O XSQUKJJJFZCRTK-UHFFFAOYSA-N 0.000 description 4
- XLOMVQKBTHCTTD-UHFFFAOYSA-N Zinc monoxide Chemical compound [Zn]=O XLOMVQKBTHCTTD-UHFFFAOYSA-N 0.000 description 4
- 239000000654 additive Substances 0.000 description 4
- 230000000996 additive effect Effects 0.000 description 4
- BJRNKVDFDLYUGJ-ZIQFBCGOSA-N alpha-Arbutin Chemical compound O[C@@H]1[C@@H](O)[C@H](O)[C@@H](CO)O[C@@H]1OC1=CC=C(O)C=C1 BJRNKVDFDLYUGJ-ZIQFBCGOSA-N 0.000 description 4
- 150000003863 ammonium salts Chemical class 0.000 description 4
- 230000000507 anthelmentic effect Effects 0.000 description 4
- 230000001166 anti-perspirative effect Effects 0.000 description 4
- 230000002421 anti-septic effect Effects 0.000 description 4
- 239000010692 aromatic oil Substances 0.000 description 4
- QVGXLLKOCUKJST-UHFFFAOYSA-N atomic oxygen Chemical compound [O] QVGXLLKOCUKJST-UHFFFAOYSA-N 0.000 description 4
- 235000012677 beetroot red Nutrition 0.000 description 4
- HUMNYLRZRPPJDN-UHFFFAOYSA-N benzaldehyde Chemical compound O=CC1=CC=CC=C1 HUMNYLRZRPPJDN-UHFFFAOYSA-N 0.000 description 4
- 235000010233 benzoic acid Nutrition 0.000 description 4
- QUKGYYKBILRGFE-UHFFFAOYSA-N benzyl acetate Chemical compound CC(=O)OCC1=CC=CC=C1 QUKGYYKBILRGFE-UHFFFAOYSA-N 0.000 description 4
- 235000002185 betanin Nutrition 0.000 description 4
- 230000015572 biosynthetic process Effects 0.000 description 4
- 210000000481 breast Anatomy 0.000 description 4
- GDTBXPJZTBHREO-UHFFFAOYSA-N bromine Substances BrBr GDTBXPJZTBHREO-UHFFFAOYSA-N 0.000 description 4
- 229910052794 bromium Inorganic materials 0.000 description 4
- 239000004359 castor oil Substances 0.000 description 4
- 235000019438 castor oil Nutrition 0.000 description 4
- QMVPMAAFGQKVCJ-UHFFFAOYSA-N citronellol Chemical compound OCCC(C)CCC=C(C)C QMVPMAAFGQKVCJ-UHFFFAOYSA-N 0.000 description 4
- DIOQZVSQGTUSAI-UHFFFAOYSA-N decane Chemical compound CCCCCCCCCC DIOQZVSQGTUSAI-UHFFFAOYSA-N 0.000 description 4
- GHVNFZFCNZKVNT-UHFFFAOYSA-N decanoic acid Chemical compound CCCCCCCCCC(O)=O GHVNFZFCNZKVNT-UHFFFAOYSA-N 0.000 description 4
- 239000004205 dimethyl polysiloxane Substances 0.000 description 4
- 235000013870 dimethyl polysiloxane Nutrition 0.000 description 4
- UKMSUNONTOPOIO-UHFFFAOYSA-N docosanoic acid Chemical compound CCCCCCCCCCCCCCCCCCCCCC(O)=O UKMSUNONTOPOIO-UHFFFAOYSA-N 0.000 description 4
- POULHZVOKOAJMA-UHFFFAOYSA-N dodecanoic acid Chemical compound CCCCCCCCCCCC(O)=O POULHZVOKOAJMA-UHFFFAOYSA-N 0.000 description 4
- ZQPPMHVWECSIRJ-MDZDMXLPSA-N elaidic acid Chemical compound CCCCCCCC\C=C\CCCCCCCC(O)=O ZQPPMHVWECSIRJ-MDZDMXLPSA-N 0.000 description 4
- 125000005456 glyceride group Chemical group 0.000 description 4
- ZEMPKEQAKRGZGQ-XOQCFJPHSA-N glycerol triricinoleate Natural products CCCCCC[C@@H](O)CC=CCCCCCCCC(=O)OC[C@@H](COC(=O)CCCCCCCC=CC[C@@H](O)CCCCCC)OC(=O)CCCCCCCC=CC[C@H](O)CCCCCC ZEMPKEQAKRGZGQ-XOQCFJPHSA-N 0.000 description 4
- IPCSVZSSVZVIGE-UHFFFAOYSA-N hexadecanoic acid Chemical compound CCCCCCCCCCCCCCCC(O)=O IPCSVZSSVZVIGE-UHFFFAOYSA-N 0.000 description 4
- ZSIAUFGUXNUGDI-UHFFFAOYSA-N hexan-1-ol Chemical compound CCCCCCO ZSIAUFGUXNUGDI-UHFFFAOYSA-N 0.000 description 4
- VKOBVWXKNCXXDE-UHFFFAOYSA-N icosanoic acid Chemical compound CCCCCCCCCCCCCCCCCCCC(O)=O VKOBVWXKNCXXDE-UHFFFAOYSA-N 0.000 description 4
- CDOSHBSSFJOMGT-UHFFFAOYSA-N linalool Chemical compound CC(C)=CCCC(C)(O)C=C CDOSHBSSFJOMGT-UHFFFAOYSA-N 0.000 description 4
- 229910052757 nitrogen Inorganic materials 0.000 description 4
- 229940055577 oleyl alcohol Drugs 0.000 description 4
- 229940059574 pentaerithrityl Drugs 0.000 description 4
- 229920000435 poly(dimethylsiloxane) Polymers 0.000 description 4
- 229920001223 polyethylene glycol Polymers 0.000 description 4
- 229920000642 polymer Polymers 0.000 description 4
- 229920005862 polyol Polymers 0.000 description 4
- 229920001296 polysiloxane Polymers 0.000 description 4
- 125000002924 primary amino group Chemical group [H]N([H])* 0.000 description 4
- 229960004889 salicylic acid Drugs 0.000 description 4
- 229920006395 saturated elastomer Polymers 0.000 description 4
- 229920002545 silicone oil Polymers 0.000 description 4
- 239000000243 solution Substances 0.000 description 4
- DTGKSKDOIYIVQL-WEDXCCLWSA-N (+)-borneol Chemical group C1C[C@@]2(C)[C@@H](O)C[C@@H]1C2(C)C DTGKSKDOIYIVQL-WEDXCCLWSA-N 0.000 description 3
- ALSTYHKOOCGGFT-KTKRTIGZSA-N (9Z)-octadecen-1-ol Chemical compound CCCCCCCC\C=C/CCCCCCCCO ALSTYHKOOCGGFT-KTKRTIGZSA-N 0.000 description 3
- 150000005207 1,3-dihydroxybenzenes Chemical class 0.000 description 3
- IIZPXYDJLKNOIY-JXPKJXOSSA-N 1-palmitoyl-2-arachidonoyl-sn-glycero-3-phosphocholine Chemical compound CCCCCCCCCCCCCCCC(=O)OC[C@H](COP([O-])(=O)OCC[N+](C)(C)C)OC(=O)CCC\C=C/C\C=C/C\C=C/C\C=C/CCCCC IIZPXYDJLKNOIY-JXPKJXOSSA-N 0.000 description 3
- RKMGAJGJIURJSJ-UHFFFAOYSA-N 2,2,6,6-Tetramethylpiperidine Substances CC1(C)CCCC(C)(C)N1 RKMGAJGJIURJSJ-UHFFFAOYSA-N 0.000 description 3
- NIXOWILDQLNWCW-UHFFFAOYSA-N 2-Propenoic acid Natural products OC(=O)C=C NIXOWILDQLNWCW-UHFFFAOYSA-N 0.000 description 3
- ZOEGTCHMBZBJPL-UHFFFAOYSA-N 8ah-chromene Chemical compound C1=CC=CC2OC=CC=C21 ZOEGTCHMBZBJPL-UHFFFAOYSA-N 0.000 description 3
- POJWUDADGALRAB-PVQJCKRUSA-N Allantoin Natural products NC(=O)N[C@@H]1NC(=O)NC1=O POJWUDADGALRAB-PVQJCKRUSA-N 0.000 description 3
- 241001044369 Amphion Species 0.000 description 3
- 108010087806 Carnosine Proteins 0.000 description 3
- VFLDPWHFBUODDF-FCXRPNKRSA-N Curcumin Natural products C1=C(O)C(OC)=CC(\C=C\C(=O)CC(=O)\C=C\C=2C=C(OC)C(O)=CC=2)=C1 VFLDPWHFBUODDF-FCXRPNKRSA-N 0.000 description 3
- FBPFZTCFMRRESA-FSIIMWSLSA-N D-Glucitol Natural products OC[C@H](O)[C@H](O)[C@@H](O)[C@H](O)CO FBPFZTCFMRRESA-FSIIMWSLSA-N 0.000 description 3
- SNRUBQQJIBEYMU-UHFFFAOYSA-N Dodecane Chemical group CCCCCCCCCCCC SNRUBQQJIBEYMU-UHFFFAOYSA-N 0.000 description 3
- OTMSDBZUPAUEDD-UHFFFAOYSA-N Ethane Chemical compound CC OTMSDBZUPAUEDD-UHFFFAOYSA-N 0.000 description 3
- FWKQNCXZGNBPFD-UHFFFAOYSA-N Guaiazulene Chemical compound CC(C)C1=CC=C(C)C2=CC=C(C)C2=C1 FWKQNCXZGNBPFD-UHFFFAOYSA-N 0.000 description 3
- CQOVPNPJLQNMDC-UHFFFAOYSA-N N-beta-alanyl-L-histidine Natural products NCCC(=O)NC(C(O)=O)CC1=CN=CN1 CQOVPNPJLQNMDC-UHFFFAOYSA-N 0.000 description 3
- FSYKKLYZXJSNPZ-UHFFFAOYSA-N N-methylaminoacetic acid Natural products C[NH2+]CC([O-])=O FSYKKLYZXJSNPZ-UHFFFAOYSA-N 0.000 description 3
- KDYFGRWQOYBRFD-UHFFFAOYSA-N Succinic acid Natural products OC(=O)CCC(O)=O KDYFGRWQOYBRFD-UHFFFAOYSA-N 0.000 description 3
- ZMANZCXQSJIPKH-UHFFFAOYSA-N Triethylamine Chemical compound CCN(CC)CC ZMANZCXQSJIPKH-UHFFFAOYSA-N 0.000 description 3
- HCHKCACWOHOZIP-UHFFFAOYSA-N Zinc Chemical compound [Zn] HCHKCACWOHOZIP-UHFFFAOYSA-N 0.000 description 3
- 239000001361 adipic acid Substances 0.000 description 3
- 235000011037 adipic acid Nutrition 0.000 description 3
- 230000001476 alcoholic effect Effects 0.000 description 3
- 229960000458 allantoin Drugs 0.000 description 3
- 229940033280 alpha-arbutin Drugs 0.000 description 3
- BJEPYKJPYRNKOW-UHFFFAOYSA-N alpha-hydroxysuccinic acid Natural products OC(=O)C(O)CC(O)=O BJEPYKJPYRNKOW-UHFFFAOYSA-N 0.000 description 3
- DTOSIQBPPRVQHS-PDBXOOCHSA-N alpha-linolenic acid Chemical compound CC\C=C/C\C=C/C\C=C/CCCCCCCC(O)=O DTOSIQBPPRVQHS-PDBXOOCHSA-N 0.000 description 3
- 125000003368 amide group Chemical group 0.000 description 3
- 150000001408 amides Chemical class 0.000 description 3
- 229940024606 amino acid Drugs 0.000 description 3
- 239000003945 anionic surfactant Substances 0.000 description 3
- 150000001450 anions Chemical class 0.000 description 3
- 230000000844 anti-bacterial effect Effects 0.000 description 3
- 235000010323 ascorbic acid Nutrition 0.000 description 3
- 229960005070 ascorbic acid Drugs 0.000 description 3
- 239000011668 ascorbic acid Substances 0.000 description 3
- QRUDEWIWKLJBPS-UHFFFAOYSA-N benzotriazole Chemical compound C1=CC=C2N[N][N]C2=C1 QRUDEWIWKLJBPS-UHFFFAOYSA-N 0.000 description 3
- 239000012964 benzotriazole Substances 0.000 description 3
- WQZGKKKJIJFFOK-VFUOTHLCSA-N beta-D-glucose Chemical compound OC[C@H]1O[C@@H](O)[C@H](O)[C@@H](O)[C@@H]1O WQZGKKKJIJFFOK-VFUOTHLCSA-N 0.000 description 3
- 125000000484 butyl group Chemical group [H]C([*])([H])C([H])([H])C([H])([H])C([H])([H])[H] 0.000 description 3
- CQOVPNPJLQNMDC-ZETCQYMHSA-N carnosine Chemical compound [NH3+]CCC(=O)N[C@H](C([O-])=O)CC1=CNC=N1 CQOVPNPJLQNMDC-ZETCQYMHSA-N 0.000 description 3
- 125000002091 cationic group Chemical group 0.000 description 3
- HVYWMOMLDIMFJA-DPAQBDIFSA-N cholesterol group Chemical group [C@@H]1(CC[C@H]2[C@@H]3CC=C4C[C@@H](O)CC[C@]4(C)[C@H]3CC[C@]12C)[C@H](C)CCCC(C)C HVYWMOMLDIMFJA-DPAQBDIFSA-N 0.000 description 3
- 239000012459 cleaning agent Substances 0.000 description 3
- 239000011538 cleaning material Substances 0.000 description 3
- 239000003086 colorant Substances 0.000 description 3
- 125000004093 cyano group Chemical group *C#N 0.000 description 3
- 229940008099 dimethicone Drugs 0.000 description 3
- 125000003438 dodecyl group Chemical group [H]C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])* 0.000 description 3
- 229910052731 fluorine Inorganic materials 0.000 description 3
- 239000011737 fluorine Substances 0.000 description 3
- 239000008103 glucose Substances 0.000 description 3
- 229930182478 glucoside Natural products 0.000 description 3
- RWSXRVCMGQZWBV-WDSKDSINSA-N glutathione Chemical compound OC(=O)[C@@H](N)CCC(=O)N[C@@H](CS)C(=O)NCC(O)=O RWSXRVCMGQZWBV-WDSKDSINSA-N 0.000 description 3
- 235000003969 glutathione Nutrition 0.000 description 3
- 229960003180 glutathione Drugs 0.000 description 3
- 150000002338 glycosides Chemical class 0.000 description 3
- FNAZRRHPUDJQCJ-UHFFFAOYSA-N henicosane Chemical compound CCCCCCCCCCCCCCCCCCCCC FNAZRRHPUDJQCJ-UHFFFAOYSA-N 0.000 description 3
- 150000002430 hydrocarbons Chemical class 0.000 description 3
- 125000004435 hydrogen atom Chemical group [H]* 0.000 description 3
- 125000001449 isopropyl group Chemical group [H]C([H])([H])C([H])(*)C([H])([H])[H] 0.000 description 3
- 150000002576 ketones Chemical class 0.000 description 3
- 235000014655 lactic acid Nutrition 0.000 description 3
- 239000004310 lactic acid Substances 0.000 description 3
- 229940067606 lecithin Drugs 0.000 description 3
- 239000000787 lecithin Substances 0.000 description 3
- 235000010445 lecithin Nutrition 0.000 description 3
- 239000002502 liposome Substances 0.000 description 3
- 229910052749 magnesium Inorganic materials 0.000 description 3
- 239000011777 magnesium Substances 0.000 description 3
- 239000001630 malic acid Substances 0.000 description 3
- 235000011090 malic acid Nutrition 0.000 description 3
- 238000000034 method Methods 0.000 description 3
- 239000004530 micro-emulsion Substances 0.000 description 3
- 125000004573 morpholin-4-yl group Chemical group N1(CCOCC1)* 0.000 description 3
- VLKZOEOYAKHREP-UHFFFAOYSA-N n-Hexane Chemical compound CCCCCC VLKZOEOYAKHREP-UHFFFAOYSA-N 0.000 description 3
- XMLQWXUVTXCDDL-UHFFFAOYSA-N oleyl alcohol Natural products CCCCCCC=CCCCCCCCCCCO XMLQWXUVTXCDDL-UHFFFAOYSA-N 0.000 description 3
- 230000003647 oxidation Effects 0.000 description 3
- 238000007254 oxidation reaction Methods 0.000 description 3
- 239000012188 paraffin wax Substances 0.000 description 3
- WXZMFSXDPGVJKK-UHFFFAOYSA-N pentaerythritol Chemical compound OCC(CO)(CO)CO WXZMFSXDPGVJKK-UHFFFAOYSA-N 0.000 description 3
- 239000002304 perfume Substances 0.000 description 3
- 150000003053 piperidines Chemical class 0.000 description 3
- 229920001184 polypeptide Polymers 0.000 description 3
- 229920000036 polyvinylpyrrolidone Polymers 0.000 description 3
- 235000013855 polyvinylpyrrolidone Nutrition 0.000 description 3
- XAEFZNCEHLXOMS-UHFFFAOYSA-M potassium benzoate Chemical compound [K+].[O-]C(=O)C1=CC=CC=C1 XAEFZNCEHLXOMS-UHFFFAOYSA-M 0.000 description 3
- 102000004196 processed proteins & peptides Human genes 0.000 description 3
- 230000004224 protection Effects 0.000 description 3
- 159000000000 sodium salts Chemical class 0.000 description 3
- 239000000600 sorbitol Substances 0.000 description 3
- 235000013599 spices Nutrition 0.000 description 3
- 239000003381 stabilizer Substances 0.000 description 3
- 238000003756 stirring Methods 0.000 description 3
- 235000000346 sugar Nutrition 0.000 description 3
- 238000012360 testing method Methods 0.000 description 3
- SZHOJFHSIKHZHA-UHFFFAOYSA-N tridecanoic acid Chemical compound CCCCCCCCCCCCC(O)=O SZHOJFHSIKHZHA-UHFFFAOYSA-N 0.000 description 3
- RSJKGSCJYJTIGS-UHFFFAOYSA-N undecane Chemical compound CCCCCCCCCCC RSJKGSCJYJTIGS-UHFFFAOYSA-N 0.000 description 3
- 235000021122 unsaturated fatty acids Nutrition 0.000 description 3
- 150000004670 unsaturated fatty acids Chemical class 0.000 description 3
- 229910052725 zinc Inorganic materials 0.000 description 3
- 239000011701 zinc Substances 0.000 description 3
- 239000002888 zwitterionic surfactant Substances 0.000 description 3
- JNYAEWCLZODPBN-JGWLITMVSA-N (2r,3r,4s)-2-[(1r)-1,2-dihydroxyethyl]oxolane-3,4-diol Chemical compound OC[C@@H](O)[C@H]1OC[C@H](O)[C@H]1O JNYAEWCLZODPBN-JGWLITMVSA-N 0.000 description 2
- 239000001490 (3R)-3,7-dimethylocta-1,6-dien-3-ol Substances 0.000 description 2
- BZANQLIRVMZFOS-ZKZCYXTQSA-N (3r,4s,5s,6r)-2-butoxy-6-(hydroxymethyl)oxane-3,4,5-triol Chemical compound CCCCOC1O[C@H](CO)[C@@H](O)[C@H](O)[C@H]1O BZANQLIRVMZFOS-ZKZCYXTQSA-N 0.000 description 2
- HOVAGTYPODGVJG-UVSYOFPXSA-N (3s,5r)-2-(hydroxymethyl)-6-methoxyoxane-3,4,5-triol Chemical compound COC1OC(CO)[C@@H](O)C(O)[C@H]1O HOVAGTYPODGVJG-UVSYOFPXSA-N 0.000 description 2
- OYHQOLUKZRVURQ-NTGFUMLPSA-N (9Z,12Z)-9,10,12,13-tetratritiooctadeca-9,12-dienoic acid Chemical compound C(CCCCCCC\C(=C(/C\C(=C(/CCCCC)\[3H])\[3H])\[3H])\[3H])(=O)O OYHQOLUKZRVURQ-NTGFUMLPSA-N 0.000 description 2
- IKYKEVDKGZYRMQ-PDBXOOCHSA-N (9Z,12Z,15Z)-octadecatrien-1-ol Chemical compound CC\C=C/C\C=C/C\C=C/CCCCCCCCO IKYKEVDKGZYRMQ-PDBXOOCHSA-N 0.000 description 2
- QMVPMAAFGQKVCJ-SNVBAGLBSA-N (R)-(+)-citronellol Natural products OCC[C@H](C)CCC=C(C)C QMVPMAAFGQKVCJ-SNVBAGLBSA-N 0.000 description 2
- CDOSHBSSFJOMGT-JTQLQIEISA-N (R)-linalool Natural products CC(C)=CCC[C@@](C)(O)C=C CDOSHBSSFJOMGT-JTQLQIEISA-N 0.000 description 2
- BJEPYKJPYRNKOW-REOHCLBHSA-N (S)-malic acid Chemical compound OC(=O)[C@@H](O)CC(O)=O BJEPYKJPYRNKOW-REOHCLBHSA-N 0.000 description 2
- 150000005208 1,4-dihydroxybenzenes Chemical class 0.000 description 2
- SRUQARLMFOLRDN-UHFFFAOYSA-N 1-(2,4,5-Trihydroxyphenyl)-1-butanone Chemical compound CCCC(=O)C1=CC(O)=C(O)C=C1O SRUQARLMFOLRDN-UHFFFAOYSA-N 0.000 description 2
- KBPLFHHGFOOTCA-UHFFFAOYSA-N 1-Octanol Chemical compound CCCCCCCCO KBPLFHHGFOOTCA-UHFFFAOYSA-N 0.000 description 2
- WCIQNYOXLZQQMU-UHFFFAOYSA-N 1-Phenylethyl propanoate Chemical compound CCC(=O)OC(C)C1=CC=CC=C1 WCIQNYOXLZQQMU-UHFFFAOYSA-N 0.000 description 2
- LTSWUFKUZPPYEG-UHFFFAOYSA-N 1-decoxydecane Chemical class CCCCCCCCCCOCCCCCCCCCC LTSWUFKUZPPYEG-UHFFFAOYSA-N 0.000 description 2
- VBICKXHEKHSIBG-UHFFFAOYSA-N 1-monostearoylglycerol Chemical compound CCCCCCCCCCCCCCCCCC(=O)OCC(O)CO VBICKXHEKHSIBG-UHFFFAOYSA-N 0.000 description 2
- 229940114072 12-hydroxystearic acid Drugs 0.000 description 2
- FPIPGXGPPPQFEQ-UHFFFAOYSA-N 13-cis retinol Natural products OCC=C(C)C=CC=C(C)C=CC1=C(C)CCCC1(C)C FPIPGXGPPPQFEQ-UHFFFAOYSA-N 0.000 description 2
- WNWHHMBRJJOGFJ-UHFFFAOYSA-N 16-methylheptadecan-1-ol Chemical compound CC(C)CCCCCCCCCCCCCCCO WNWHHMBRJJOGFJ-UHFFFAOYSA-N 0.000 description 2
- ZEMPKEQAKRGZGQ-AAKVHIHISA-N 2,3-bis[[(z)-12-hydroxyoctadec-9-enoyl]oxy]propyl (z)-12-hydroxyoctadec-9-enoate Chemical compound CCCCCCC(O)C\C=C/CCCCCCCC(=O)OCC(OC(=O)CCCCCCC\C=C/CC(O)CCCCCC)COC(=O)CCCCCCC\C=C/CC(O)CCCCCC ZEMPKEQAKRGZGQ-AAKVHIHISA-N 0.000 description 2
- ASKIVFGGGGIGKH-UHFFFAOYSA-N 2,3-dihydroxypropyl 16-methylheptadecanoate Chemical compound CC(C)CCCCCCCCCCCCCCC(=O)OCC(O)CO ASKIVFGGGGIGKH-UHFFFAOYSA-N 0.000 description 2
- HZAXFHJVJLSVMW-UHFFFAOYSA-N 2-Aminoethan-1-ol Chemical compound NCCO HZAXFHJVJLSVMW-UHFFFAOYSA-N 0.000 description 2
- TXBCBTDQIULDIA-UHFFFAOYSA-N 2-[[3-hydroxy-2,2-bis(hydroxymethyl)propoxy]methyl]-2-(hydroxymethyl)propane-1,3-diol Chemical compound OCC(CO)(CO)COCC(CO)(CO)CO TXBCBTDQIULDIA-UHFFFAOYSA-N 0.000 description 2
- YIWUKEYIRIRTPP-UHFFFAOYSA-N 2-ethylhexan-1-ol Chemical compound CCCCC(CC)CO YIWUKEYIRIRTPP-UHFFFAOYSA-N 0.000 description 2
- PMNLUUOXGOOLSP-UHFFFAOYSA-N 2-mercaptopropanoic acid Chemical compound CC(S)C(O)=O PMNLUUOXGOOLSP-UHFFFAOYSA-N 0.000 description 2
- QCDWFXQBSFUVSP-UHFFFAOYSA-N 2-phenoxyethanol Chemical compound OCCOC1=CC=CC=C1 QCDWFXQBSFUVSP-UHFFFAOYSA-N 0.000 description 2
- WRMNZCZEMHIOCP-UHFFFAOYSA-N 2-phenylethanol Chemical compound OCCC1=CC=CC=C1 WRMNZCZEMHIOCP-UHFFFAOYSA-N 0.000 description 2
- ZPSJGADGUYYRKE-UHFFFAOYSA-N 2H-pyran-2-one Chemical class O=C1C=CC=CO1 ZPSJGADGUYYRKE-UHFFFAOYSA-N 0.000 description 2
- RGHHSNMVTDWUBI-UHFFFAOYSA-N 4-hydroxybenzaldehyde Chemical compound OC1=CC=C(C=O)C=C1 RGHHSNMVTDWUBI-UHFFFAOYSA-N 0.000 description 2
- CSHZYWUPJWVTMQ-UHFFFAOYSA-N 4-n-Butylresorcinol Chemical compound CCCCC1=CC=C(O)C=C1O CSHZYWUPJWVTMQ-UHFFFAOYSA-N 0.000 description 2
- DHMQDGOQFOQNFH-UHFFFAOYSA-M Aminoacetate Chemical compound NCC([O-])=O DHMQDGOQFOQNFH-UHFFFAOYSA-M 0.000 description 2
- NLXLAEXVIDQMFP-UHFFFAOYSA-N Ammonia chloride Chemical compound [NH4+].[Cl-] NLXLAEXVIDQMFP-UHFFFAOYSA-N 0.000 description 2
- 208000037259 Amyloid Plaque Diseases 0.000 description 2
- IJGRMHOSHXDMSA-UHFFFAOYSA-N Atomic nitrogen Chemical compound N#N IJGRMHOSHXDMSA-UHFFFAOYSA-N 0.000 description 2
- 235000021357 Behenic acid Nutrition 0.000 description 2
- ZCTQGTTXIYCGGC-UHFFFAOYSA-N Benzyl salicylate Chemical compound OC1=CC=CC=C1C(=O)OCC1=CC=CC=C1 ZCTQGTTXIYCGGC-UHFFFAOYSA-N 0.000 description 2
- UYWQUFXKFGHYNT-UHFFFAOYSA-N Benzylformate Chemical compound O=COCC1=CC=CC=C1 UYWQUFXKFGHYNT-UHFFFAOYSA-N 0.000 description 2
- BPYKTIZUTYGOLE-IFADSCNNSA-N Bilirubin Chemical compound N1C(=O)C(C)=C(C=C)\C1=C\C1=C(C)C(CCC(O)=O)=C(CC2=C(C(C)=C(\C=C/3C(=C(C=C)C(=O)N\3)C)N2)CCC(O)=O)N1 BPYKTIZUTYGOLE-IFADSCNNSA-N 0.000 description 2
- 241000717739 Boswellia sacra Species 0.000 description 2
- DPUOLQHDNGRHBS-UHFFFAOYSA-N Brassidinsaeure Natural products CCCCCCCCC=CCCCCCCCCCCCC(O)=O DPUOLQHDNGRHBS-UHFFFAOYSA-N 0.000 description 2
- 239000005632 Capric acid (CAS 334-48-5) Substances 0.000 description 2
- 235000005747 Carum carvi Nutrition 0.000 description 2
- 240000000467 Carum carvi Species 0.000 description 2
- 229920001661 Chitosan Polymers 0.000 description 2
- 206010008570 Chloasma Diseases 0.000 description 2
- RKWGIWYCVPQPMF-UHFFFAOYSA-N Chloropropamide Chemical compound CCCNC(=O)NS(=O)(=O)C1=CC=C(Cl)C=C1 RKWGIWYCVPQPMF-UHFFFAOYSA-N 0.000 description 2
- KRKNYBCHXYNGOX-UHFFFAOYSA-K Citrate Chemical compound [O-]C(=O)CC(O)(CC([O-])=O)C([O-])=O KRKNYBCHXYNGOX-UHFFFAOYSA-K 0.000 description 2
- 102000008186 Collagen Human genes 0.000 description 2
- 108010035532 Collagen Proteins 0.000 description 2
- 240000004784 Cymbopogon citratus Species 0.000 description 2
- 235000017897 Cymbopogon citratus Nutrition 0.000 description 2
- 108090000695 Cytokines Proteins 0.000 description 2
- 102000004127 Cytokines Human genes 0.000 description 2
- ZAKOWWREFLAJOT-CEFNRUSXSA-N D-alpha-tocopherylacetate Chemical compound CC(=O)OC1=C(C)C(C)=C2O[C@@](CCC[C@H](C)CCC[C@H](C)CCCC(C)C)(C)CCC2=C1C ZAKOWWREFLAJOT-CEFNRUSXSA-N 0.000 description 2
- SNPLKNRPJHDVJA-ZETCQYMHSA-N D-panthenol Chemical compound OCC(C)(C)[C@@H](O)C(=O)NCCCO SNPLKNRPJHDVJA-ZETCQYMHSA-N 0.000 description 2
- 108020004414 DNA Proteins 0.000 description 2
- 102000053602 DNA Human genes 0.000 description 2
- LCGLNKUTAGEVQW-UHFFFAOYSA-N Dimethyl ether Chemical compound COC LCGLNKUTAGEVQW-UHFFFAOYSA-N 0.000 description 2
- KCXVZYZYPLLWCC-UHFFFAOYSA-N EDTA Chemical compound OC(=O)CN(CC(O)=O)CCN(CC(O)=O)CC(O)=O KCXVZYZYPLLWCC-UHFFFAOYSA-N 0.000 description 2
- 108090000790 Enzymes Proteins 0.000 description 2
- 102000004190 Enzymes Human genes 0.000 description 2
- URXZXNYJPAJJOQ-UHFFFAOYSA-N Erucic acid Natural products CCCCCCC=CCCCCCCCCCCCC(O)=O URXZXNYJPAJJOQ-UHFFFAOYSA-N 0.000 description 2
- 229940122601 Esterase inhibitor Drugs 0.000 description 2
- 241000628997 Flos Species 0.000 description 2
- YCKRFDGAMUMZLT-UHFFFAOYSA-N Fluorine atom Chemical compound [F] YCKRFDGAMUMZLT-UHFFFAOYSA-N 0.000 description 2
- WSFSSNUMVMOOMR-UHFFFAOYSA-N Formaldehyde Chemical compound O=C WSFSSNUMVMOOMR-UHFFFAOYSA-N 0.000 description 2
- 239000004863 Frankincense Substances 0.000 description 2
- 239000005792 Geraniol Substances 0.000 description 2
- GLZPCOQZEFWAFX-YFHOEESVSA-N Geraniol Natural products CC(C)=CCC\C(C)=C/CO GLZPCOQZEFWAFX-YFHOEESVSA-N 0.000 description 2
- AEMRFAOFKBGASW-UHFFFAOYSA-N Glycolic acid Chemical compound OCC(O)=O AEMRFAOFKBGASW-UHFFFAOYSA-N 0.000 description 2
- 229920002907 Guar gum Polymers 0.000 description 2
- QAOBEOXFSUJDJL-QFLFCSHESA-O Hyacinthin Natural products O=C(OC[C@@H]1[C@@H](O)[C@@H](O)[C@@H](O)[C@H](Oc2c(-c3cc(O)c(O)cc3)[o+]c3c(c(O)cc(O)c3)c2)O1)/C=C/c1ccc(O)cc1 QAOBEOXFSUJDJL-QFLFCSHESA-O 0.000 description 2
- MHAJPDPJQMAIIY-UHFFFAOYSA-N Hydrogen peroxide Chemical compound OO MHAJPDPJQMAIIY-UHFFFAOYSA-N 0.000 description 2
- SIKJAQJRHWYJAI-UHFFFAOYSA-N Indole Chemical compound C1=CC=C2NC=CC2=C1 SIKJAQJRHWYJAI-UHFFFAOYSA-N 0.000 description 2
- XEEYBQQBJWHFJM-UHFFFAOYSA-N Iron Chemical compound [Fe] XEEYBQQBJWHFJM-UHFFFAOYSA-N 0.000 description 2
- PWKSKIMOESPYIA-BYPYZUCNSA-N L-N-acetyl-Cysteine Chemical compound CC(=O)N[C@@H](CS)C(O)=O PWKSKIMOESPYIA-BYPYZUCNSA-N 0.000 description 2
- 239000005639 Lauric acid Substances 0.000 description 2
- UPYKUZBSLRQECL-UKMVMLAPSA-N Lycopene Natural products CC(=C/C=C/C=C(C)/C=C/C=C(C)/C=C/C1C(=C)CCCC1(C)C)C=CC=C(/C)C=CC2C(=C)CCCC2(C)C UPYKUZBSLRQECL-UKMVMLAPSA-N 0.000 description 2
- FYYHWMGAXLPEAU-UHFFFAOYSA-N Magnesium Chemical compound [Mg] FYYHWMGAXLPEAU-UHFFFAOYSA-N 0.000 description 2
- XUMBMVFBXHLACL-UHFFFAOYSA-N Melanin Chemical compound O=C1C(=O)C(C2=CNC3=C(C(C(=O)C4=C32)=O)C)=C2C4=CNC2=C1C XUMBMVFBXHLACL-UHFFFAOYSA-N 0.000 description 2
- 229920003091 Methocel™ Polymers 0.000 description 2
- UUQHKWMIDYRWHH-UHFFFAOYSA-N Methyl beta-orcinolcarboxylate Chemical group COC(=O)C1=C(C)C=C(O)C(C)=C1O UUQHKWMIDYRWHH-UHFFFAOYSA-N 0.000 description 2
- 108010038807 Oligopeptides Proteins 0.000 description 2
- 102000015636 Oligopeptides Human genes 0.000 description 2
- 235000019502 Orange oil Nutrition 0.000 description 2
- NBIIXXVUZAFLBC-UHFFFAOYSA-N Phosphoric acid Chemical compound OP(O)(O)=O NBIIXXVUZAFLBC-UHFFFAOYSA-N 0.000 description 2
- VYGQUTWHTHXGQB-FFHKNEKCSA-N Retinol Palmitate Chemical compound CCCCCCCCCCCCCCCC(=O)OC\C=C(/C)\C=C\C=C(/C)\C=C\C1=C(C)CCCC1(C)C VYGQUTWHTHXGQB-FFHKNEKCSA-N 0.000 description 2
- 108010077895 Sarcosine Proteins 0.000 description 2
- FAPWRFPIFSIZLT-UHFFFAOYSA-M Sodium chloride Chemical compound [Na+].[Cl-] FAPWRFPIFSIZLT-UHFFFAOYSA-M 0.000 description 2
- 229920002125 Sokalan® Polymers 0.000 description 2
- XOAAWQZATWQOTB-UHFFFAOYSA-N Taurine Natural products NCCS(O)(=O)=O XOAAWQZATWQOTB-UHFFFAOYSA-N 0.000 description 2
- 240000007313 Tilia cordata Species 0.000 description 2
- ZFOZVQLOBQUTQQ-UHFFFAOYSA-N Tributyl citrate Chemical compound CCCCOC(=O)CC(O)(C(=O)OCCCC)CC(=O)OCCCC ZFOZVQLOBQUTQQ-UHFFFAOYSA-N 0.000 description 2
- ZJCCRDAZUWHFQH-UHFFFAOYSA-N Trimethylolpropane Chemical compound CCC(CO)(CO)CO ZJCCRDAZUWHFQH-UHFFFAOYSA-N 0.000 description 2
- XTXRWKRVRITETP-UHFFFAOYSA-N Vinyl acetate Chemical compound CC(=O)OC=C XTXRWKRVRITETP-UHFFFAOYSA-N 0.000 description 2
- FPIPGXGPPPQFEQ-BOOMUCAASA-N Vitamin A Natural products OC/C=C(/C)\C=C\C=C(\C)/C=C/C1=C(C)CCCC1(C)C FPIPGXGPPPQFEQ-BOOMUCAASA-N 0.000 description 2
- QAOBEOXFSUJDJL-RYHKZSCWSA-O [(3s,6s)-6-[2-(3,4-dihydroxyphenyl)-5,7-dihydroxychromenylium-3-yl]oxy-3,4,5-trihydroxyoxan-2-yl]methyl (e)-3-(4-hydroxyphenyl)prop-2-enoate Chemical compound C1([C@H](C(C(O)[C@H](OC=2C(=[O+]C3=CC(O)=CC(O)=C3C=2)C=2C=C(O)C(O)=CC=2)O1)O)O)COC(=O)\C=C\C1=CC=C(O)C=C1 QAOBEOXFSUJDJL-RYHKZSCWSA-O 0.000 description 2
- 230000002159 abnormal effect Effects 0.000 description 2
- 125000002777 acetyl group Chemical group [H]C([H])([H])C(*)=O 0.000 description 2
- 229960004308 acetylcysteine Drugs 0.000 description 2
- 125000002252 acyl group Chemical group 0.000 description 2
- 239000000443 aerosol Substances 0.000 description 2
- 238000013019 agitation Methods 0.000 description 2
- 239000003513 alkali Substances 0.000 description 2
- ANVAOWXLWRTKGA-XHGAXZNDSA-N all-trans-alpha-carotene Chemical compound CC=1CCCC(C)(C)C=1/C=C/C(/C)=C/C=C/C(/C)=C/C=C/C=C(C)C=CC=C(C)C=CC1C(C)=CCCC1(C)C ANVAOWXLWRTKGA-XHGAXZNDSA-N 0.000 description 2
- FPIPGXGPPPQFEQ-OVSJKPMPSA-N all-trans-retinol Chemical compound OC\C=C(/C)\C=C\C=C(/C)\C=C\C1=C(C)CCCC1(C)C FPIPGXGPPPQFEQ-OVSJKPMPSA-N 0.000 description 2
- OBETXYAYXDNJHR-UHFFFAOYSA-N alpha-ethylcaproic acid Natural products CCCCC(CC)C(O)=O OBETXYAYXDNJHR-UHFFFAOYSA-N 0.000 description 2
- 235000020661 alpha-linolenic acid Nutrition 0.000 description 2
- VSCWAEJMTAWNJL-UHFFFAOYSA-K aluminium trichloride Chemical compound Cl[Al](Cl)Cl VSCWAEJMTAWNJL-UHFFFAOYSA-K 0.000 description 2
- 235000001014 amino acid Nutrition 0.000 description 2
- 150000001413 amino acids Chemical class 0.000 description 2
- 239000007864 aqueous solution Substances 0.000 description 2
- 229940116226 behenic acid Drugs 0.000 description 2
- RWCCWEUUXYIKHB-UHFFFAOYSA-N benzophenone Chemical compound C=1C=CC=CC=1C(=O)C1=CC=CC=C1 RWCCWEUUXYIKHB-UHFFFAOYSA-N 0.000 description 2
- 239000012965 benzophenone Substances 0.000 description 2
- 229940007550 benzyl acetate Drugs 0.000 description 2
- AKGGYBADQZYZPD-UHFFFAOYSA-N benzylacetone Chemical compound CC(=O)CCC1=CC=CC=C1 AKGGYBADQZYZPD-UHFFFAOYSA-N 0.000 description 2
- LGJMUZUPVCAVPU-UHFFFAOYSA-N beta-Sitostanol Natural products C1CC2CC(O)CCC2(C)C2C1C1CCC(C(C)CCC(CC)C(C)C)C1(C)CC2 LGJMUZUPVCAVPU-UHFFFAOYSA-N 0.000 description 2
- JGQFVRIQXUFPAH-UHFFFAOYSA-N beta-citronellol Natural products OCCC(C)CCCC(C)=C JGQFVRIQXUFPAH-UHFFFAOYSA-N 0.000 description 2
- WHGYBXFWUBPSRW-FOUAGVGXSA-N beta-cyclodextrin Chemical compound OC[C@H]([C@H]([C@@H]([C@H]1O)O)O[C@H]2O[C@@H]([C@@H](O[C@H]3O[C@H](CO)[C@H]([C@@H]([C@H]3O)O)O[C@H]3O[C@H](CO)[C@H]([C@@H]([C@H]3O)O)O[C@H]3O[C@H](CO)[C@H]([C@@H]([C@H]3O)O)O[C@H]3O[C@H](CO)[C@H]([C@@H]([C@H]3O)O)O3)[C@H](O)[C@H]2O)CO)O[C@@H]1O[C@H]1[C@H](O)[C@@H](O)[C@@H]3O[C@@H]1CO WHGYBXFWUBPSRW-FOUAGVGXSA-N 0.000 description 2
- 230000000975 bioactive effect Effects 0.000 description 2
- 239000007844 bleaching agent Substances 0.000 description 2
- RHDGNLCLDBVESU-UHFFFAOYSA-N but-3-en-4-olide Chemical compound O=C1CC=CO1 RHDGNLCLDBVESU-UHFFFAOYSA-N 0.000 description 2
- 239000001273 butane Substances 0.000 description 2
- 239000004202 carbamide Substances 0.000 description 2
- BVKZGUZCCUSVTD-UHFFFAOYSA-N carbonic acid Chemical compound OC(O)=O BVKZGUZCCUSVTD-UHFFFAOYSA-N 0.000 description 2
- 125000002915 carbonyl group Chemical group [*:2]C([*:1])=O 0.000 description 2
- 150000001732 carboxylic acid derivatives Chemical class 0.000 description 2
- 229940044199 carnosine Drugs 0.000 description 2
- 229920002678 cellulose Polymers 0.000 description 2
- 239000001913 cellulose Substances 0.000 description 2
- 239000007766 cera flava Substances 0.000 description 2
- 238000006243 chemical reaction Methods 0.000 description 2
- 229940114081 cinnamate Drugs 0.000 description 2
- 150000001851 cinnamic acid derivatives Chemical class 0.000 description 2
- NEHNMFOYXAPHSD-UHFFFAOYSA-N citronellal Chemical compound O=CCC(C)CCC=C(C)C NEHNMFOYXAPHSD-UHFFFAOYSA-N 0.000 description 2
- 235000000484 citronellol Nutrition 0.000 description 2
- 229920001436 collagen Polymers 0.000 description 2
- 238000007796 conventional method Methods 0.000 description 2
- 150000001907 coumarones Chemical class 0.000 description 2
- 239000004148 curcumin Substances 0.000 description 2
- 235000012754 curcumin Nutrition 0.000 description 2
- 229940109262 curcumin Drugs 0.000 description 2
- 229940019836 cyclamen aldehyde Drugs 0.000 description 2
- ZAKOWWREFLAJOT-UHFFFAOYSA-N d-alpha-Tocopheryl acetate Natural products CC(=O)OC1=C(C)C(C)=C2OC(CCCC(C)CCCC(C)CCCC(C)C)(C)CCC2=C1C ZAKOWWREFLAJOT-UHFFFAOYSA-N 0.000 description 2
- GVJHHUAWPYXKBD-UHFFFAOYSA-N d-alpha-tocopherol Natural products OC1=C(C)C(C)=C2OC(CCCC(C)CCCC(C)CCCC(C)C)(C)CCC2=C1C GVJHHUAWPYXKBD-UHFFFAOYSA-N 0.000 description 2
- MWKFXSUHUHTGQN-UHFFFAOYSA-N decan-1-ol Chemical compound CCCCCCCCCCO MWKFXSUHUHTGQN-UHFFFAOYSA-N 0.000 description 2
- ZBCBWPMODOFKDW-UHFFFAOYSA-N diethanolamine Chemical compound OCCNCCO ZBCBWPMODOFKDW-UHFFFAOYSA-N 0.000 description 2
- VFLDPWHFBUODDF-UHFFFAOYSA-N diferuloylmethane Natural products C1=C(O)C(OC)=CC(C=CC(=O)CC(=O)C=CC=2C=C(OC)C(O)=CC=2)=C1 VFLDPWHFBUODDF-UHFFFAOYSA-N 0.000 description 2
- GPLRAVKSCUXZTP-UHFFFAOYSA-N diglycerol Chemical compound OCC(O)COCC(O)CO GPLRAVKSCUXZTP-UHFFFAOYSA-N 0.000 description 2
- 238000006471 dimerization reaction Methods 0.000 description 2
- XBDQKXXYIPTUBI-UHFFFAOYSA-N dimethylselenoniopropionate Natural products CCC(O)=O XBDQKXXYIPTUBI-UHFFFAOYSA-N 0.000 description 2
- NOPFSRXAKWQILS-UHFFFAOYSA-N docosan-1-ol Chemical compound CCCCCCCCCCCCCCCCCCCCCCO NOPFSRXAKWQILS-UHFFFAOYSA-N 0.000 description 2
- LQZZUXJYWNFBMV-UHFFFAOYSA-N dodecan-1-ol Chemical compound CCCCCCCCCCCCO LQZZUXJYWNFBMV-UHFFFAOYSA-N 0.000 description 2
- QVBODZPPYSSMEL-UHFFFAOYSA-N dodecyl sulfate;2-hydroxyethylazanium Chemical compound NCCO.CCCCCCCCCCCCOS(O)(=O)=O QVBODZPPYSSMEL-UHFFFAOYSA-N 0.000 description 2
- 239000003974 emollient agent Substances 0.000 description 2
- JBKVHLHDHHXQEQ-UHFFFAOYSA-N epsilon-caprolactam Chemical compound O=C1CCCCCN1 JBKVHLHDHHXQEQ-UHFFFAOYSA-N 0.000 description 2
- DPUOLQHDNGRHBS-KTKRTIGZSA-N erucic acid Chemical compound CCCCCCCC\C=C/CCCCCCCCCCCC(O)=O DPUOLQHDNGRHBS-KTKRTIGZSA-N 0.000 description 2
- 239000002329 esterase inhibitor Substances 0.000 description 2
- 230000032050 esterification Effects 0.000 description 2
- 238000005886 esterification reaction Methods 0.000 description 2
- 238000007046 ethoxylation reaction Methods 0.000 description 2
- 239000000284 extract Substances 0.000 description 2
- 238000000605 extraction Methods 0.000 description 2
- 230000001815 facial effect Effects 0.000 description 2
- 150000002191 fatty alcohols Chemical class 0.000 description 2
- OVBPIULPVIDEAO-LBPRGKRZSA-N folic acid Chemical compound C=1N=C2NC(N)=NC(=O)C2=NC=1CNC1=CC=C(C(=O)N[C@@H](CCC(O)=O)C(O)=O)C=C1 OVBPIULPVIDEAO-LBPRGKRZSA-N 0.000 description 2
- 229940113087 geraniol Drugs 0.000 description 2
- JFCQEDHGNNZCLN-UHFFFAOYSA-N glutaric acid Chemical compound OC(=O)CCCC(O)=O JFCQEDHGNNZCLN-UHFFFAOYSA-N 0.000 description 2
- 150000004676 glycans Chemical class 0.000 description 2
- 239000000665 guar gum Substances 0.000 description 2
- 229960002154 guar gum Drugs 0.000 description 2
- 229910052736 halogen Inorganic materials 0.000 description 2
- 150000002367 halogens Chemical class 0.000 description 2
- NAQMVNRVTILPCV-UHFFFAOYSA-N hexamethylene diamine Natural products NCCCCCCN NAQMVNRVTILPCV-UHFFFAOYSA-N 0.000 description 2
- ACCCMOQWYVYDOT-UHFFFAOYSA-N hexane-1,1-diol Chemical compound CCCCCC(O)O ACCCMOQWYVYDOT-UHFFFAOYSA-N 0.000 description 2
- FUZZWVXGSFPDMH-UHFFFAOYSA-N hexanoic acid Chemical compound CCCCCC(O)=O FUZZWVXGSFPDMH-UHFFFAOYSA-N 0.000 description 2
- 229930195733 hydrocarbon Natural products 0.000 description 2
- 230000003165 hydrotropic effect Effects 0.000 description 2
- 125000004356 hydroxy functional group Chemical group O* 0.000 description 2
- WGCNASOHLSPBMP-UHFFFAOYSA-N hydroxyacetaldehyde Natural products OCC=O WGCNASOHLSPBMP-UHFFFAOYSA-N 0.000 description 2
- 230000002401 inhibitory effect Effects 0.000 description 2
- 239000001469 lavandula hydrida abrial herb oil Substances 0.000 description 2
- SDQFDHOLCGWZPU-UHFFFAOYSA-N lilial Chemical compound O=CC(C)CC1=CC=C(C(C)(C)C)C=C1 SDQFDHOLCGWZPU-UHFFFAOYSA-N 0.000 description 2
- 229930007744 linalool Natural products 0.000 description 2
- UWKAYLJWKGQEPM-LBPRGKRZSA-N linalyl acetate Chemical compound CC(C)=CCC[C@](C)(C=C)OC(C)=O UWKAYLJWKGQEPM-LBPRGKRZSA-N 0.000 description 2
- 229960004488 linolenic acid Drugs 0.000 description 2
- 150000002632 lipids Chemical class 0.000 description 2
- VZCYOOQTPOCHFL-UPHRSURJSA-N maleic acid Chemical compound OC(=O)\C=C/C(O)=O VZCYOOQTPOCHFL-UPHRSURJSA-N 0.000 description 2
- 239000011976 maleic acid Substances 0.000 description 2
- HCZKYJDFEPMADG-TXEJJXNPSA-N masoprocol Chemical compound C([C@H](C)[C@H](C)CC=1C=C(O)C(O)=CC=1)C1=CC=C(O)C(O)=C1 HCZKYJDFEPMADG-TXEJJXNPSA-N 0.000 description 2
- HZVOZRGWRWCICA-UHFFFAOYSA-N methanediyl Chemical compound [CH2] HZVOZRGWRWCICA-UHFFFAOYSA-N 0.000 description 2
- HOVAGTYPODGVJG-UHFFFAOYSA-N methyl beta-galactoside Natural products COC1OC(CO)C(O)C(O)C1O HOVAGTYPODGVJG-UHFFFAOYSA-N 0.000 description 2
- 238000012986 modification Methods 0.000 description 2
- 239000003607 modifier Substances 0.000 description 2
- 229940069822 monoethanolamine lauryl sulfate Drugs 0.000 description 2
- 125000000740 n-pentyl group Chemical group [H]C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])* 0.000 description 2
- FBUKVWPVBMHYJY-UHFFFAOYSA-N nonanoic acid Chemical compound CCCCCCCCC(O)=O FBUKVWPVBMHYJY-UHFFFAOYSA-N 0.000 description 2
- 239000012875 nonionic emulsifier Substances 0.000 description 2
- 239000002777 nucleoside Substances 0.000 description 2
- 150000003833 nucleoside derivatives Chemical class 0.000 description 2
- 239000002773 nucleotide Substances 0.000 description 2
- 125000003729 nucleotide group Chemical group 0.000 description 2
- GLDOVTGHNKAZLK-UHFFFAOYSA-N octadecan-1-ol Chemical compound CCCCCCCCCCCCCCCCCCO GLDOVTGHNKAZLK-UHFFFAOYSA-N 0.000 description 2
- 125000005447 octyloxy group Chemical group [H]C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])O* 0.000 description 2
- 239000002674 ointment Substances 0.000 description 2
- 239000010502 orange oil Substances 0.000 description 2
- SECPZKHBENQXJG-FPLPWBNLSA-N palmitoleic acid Chemical compound CCCCCC\C=C/CCCCCCCC(O)=O SECPZKHBENQXJG-FPLPWBNLSA-N 0.000 description 2
- 125000000913 palmityl group Chemical group [H]C([*])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])[H] 0.000 description 2
- FJKROLUGYXJWQN-UHFFFAOYSA-N papa-hydroxy-benzoic acid Natural products OC(=O)C1=CC=C(O)C=C1 FJKROLUGYXJWQN-UHFFFAOYSA-N 0.000 description 2
- QNGNSVIICDLXHT-UHFFFAOYSA-N para-ethylbenzaldehyde Natural products CCC1=CC=C(C=O)C=C1 QNGNSVIICDLXHT-UHFFFAOYSA-N 0.000 description 2
- AXCXHFKZHDEKTP-UHFFFAOYSA-N para-methoxycinnamaldehyde Natural products COC1=CC=C(C=CC=O)C=C1 AXCXHFKZHDEKTP-UHFFFAOYSA-N 0.000 description 2
- 239000002245 particle Substances 0.000 description 2
- MDHYEMXUFSJLGV-UHFFFAOYSA-N phenethyl acetate Chemical compound CC(=O)OCCC1=CC=CC=C1 MDHYEMXUFSJLGV-UHFFFAOYSA-N 0.000 description 2
- 229960005323 phenoxyethanol Drugs 0.000 description 2
- 125000005936 piperidyl group Chemical group 0.000 description 2
- 229920002401 polyacrylamide Polymers 0.000 description 2
- 239000004584 polyacrylic acid Substances 0.000 description 2
- 229920001282 polysaccharide Polymers 0.000 description 2
- 239000005017 polysaccharide Substances 0.000 description 2
- 239000001267 polyvinylpyrrolidone Substances 0.000 description 2
- 229910052700 potassium Inorganic materials 0.000 description 2
- CMDGQTVYVAKDNA-UHFFFAOYSA-N propane-1,2,3-triol;hydrate Chemical compound O.OCC(O)CO CMDGQTVYVAKDNA-UHFFFAOYSA-N 0.000 description 2
- 235000019260 propionic acid Nutrition 0.000 description 2
- 150000003180 prostaglandins Chemical class 0.000 description 2
- 235000018102 proteins Nutrition 0.000 description 2
- 102000004169 proteins and genes Human genes 0.000 description 2
- 108090000623 proteins and genes Proteins 0.000 description 2
- ARIWANIATODDMH-UHFFFAOYSA-N rac-1-monolauroylglycerol Chemical compound CCCCCCCCCCCC(=O)OCC(O)CO ARIWANIATODDMH-UHFFFAOYSA-N 0.000 description 2
- 239000011347 resin Substances 0.000 description 2
- 229920005989 resin Polymers 0.000 description 2
- GHMLBKRAJCXXBS-UHFFFAOYSA-N resorcinol Chemical compound OC1=CC=CC(O)=C1 GHMLBKRAJCXXBS-UHFFFAOYSA-N 0.000 description 2
- CZCBTSFUTPZVKJ-UHFFFAOYSA-N rose oxide Chemical compound CC1CCOC(C=C(C)C)C1 CZCBTSFUTPZVKJ-UHFFFAOYSA-N 0.000 description 2
- 239000010670 sage oil Substances 0.000 description 2
- 229940043230 sarcosine Drugs 0.000 description 2
- 150000004671 saturated fatty acids Chemical class 0.000 description 2
- 229940116351 sebacate Drugs 0.000 description 2
- CXMXRPHRNRROMY-UHFFFAOYSA-L sebacate(2-) Chemical compound [O-]C(=O)CCCCCCCCC([O-])=O CXMXRPHRNRROMY-UHFFFAOYSA-L 0.000 description 2
- 125000002914 sec-butyl group Chemical group [H]C([H])([H])C([H])([H])C([H])(*)C([H])([H])[H] 0.000 description 2
- 210000000582 semen Anatomy 0.000 description 2
- 239000008257 shaving cream Substances 0.000 description 2
- 244000005714 skin microbiome Species 0.000 description 2
- 230000035943 smell Effects 0.000 description 2
- 230000001954 sterilising effect Effects 0.000 description 2
- 238000004659 sterilization and disinfection Methods 0.000 description 2
- ARCJQKUWGAZPFX-UHFFFAOYSA-N stilbene oxide Chemical compound O1C(C=2C=CC=CC=2)C1C1=CC=CC=C1 ARCJQKUWGAZPFX-UHFFFAOYSA-N 0.000 description 2
- 239000000758 substrate Substances 0.000 description 2
- 229960002317 succinimide Drugs 0.000 description 2
- BDHFUVZGWQCTTF-UHFFFAOYSA-M sulfonate Chemical compound [O-]S(=O)=O BDHFUVZGWQCTTF-UHFFFAOYSA-M 0.000 description 2
- 238000003786 synthesis reaction Methods 0.000 description 2
- 229940104261 taurate Drugs 0.000 description 2
- HLZKNKRTKFSKGZ-UHFFFAOYSA-N tetradecan-1-ol Chemical compound CCCCCCCCCCCCCCO HLZKNKRTKFSKGZ-UHFFFAOYSA-N 0.000 description 2
- TUNFSRHWOTWDNC-HKGQFRNVSA-N tetradecanoic acid Chemical compound CCCCCCCCCCCCC[14C](O)=O TUNFSRHWOTWDNC-HKGQFRNVSA-N 0.000 description 2
- 239000002562 thickening agent Substances 0.000 description 2
- DHCDFWKWKRSZHF-UHFFFAOYSA-L thiosulfate(2-) Chemical compound [O-]S([S-])(=O)=O DHCDFWKWKRSZHF-UHFFFAOYSA-L 0.000 description 2
- MGSRCZKZVOBKFT-UHFFFAOYSA-N thymol Chemical compound CC(C)C1=CC=C(C)C=C1O MGSRCZKZVOBKFT-UHFFFAOYSA-N 0.000 description 2
- 239000004408 titanium dioxide Substances 0.000 description 2
- 235000010384 tocopherol Nutrition 0.000 description 2
- 229930003799 tocopherol Natural products 0.000 description 2
- 229960001295 tocopherol Drugs 0.000 description 2
- 239000011732 tocopherol Substances 0.000 description 2
- RUVINXPYWBROJD-ONEGZZNKSA-N trans-anethole Chemical compound COC1=CC=C(\C=C\C)C=C1 RUVINXPYWBROJD-ONEGZZNKSA-N 0.000 description 2
- VZCYOOQTPOCHFL-UHFFFAOYSA-N trans-butenedioic acid Natural products OC(=O)C=CC(O)=O VZCYOOQTPOCHFL-UHFFFAOYSA-N 0.000 description 2
- WBYWAXJHAXSJNI-VOTSOKGWSA-M trans-cinnamate Chemical compound [O-]C(=O)\C=C\C1=CC=CC=C1 WBYWAXJHAXSJNI-VOTSOKGWSA-M 0.000 description 2
- VARQGBHBYZTYLJ-UHFFFAOYSA-N tricosan-12-one Chemical compound CCCCCCCCCCCC(=O)CCCCCCCCCCC VARQGBHBYZTYLJ-UHFFFAOYSA-N 0.000 description 2
- HDDLVZWGOPWKFW-UHFFFAOYSA-N trimethyl 2-hydroxypropane-1,2,3-tricarboxylate Chemical compound COC(=O)CC(O)(C(=O)OC)CC(=O)OC HDDLVZWGOPWKFW-UHFFFAOYSA-N 0.000 description 2
- 125000003774 valeryl group Chemical group O=C([*])C([H])([H])C([H])([H])C([H])([H])C([H])([H])[H] 0.000 description 2
- APVKGMMYGFJZHY-UHFFFAOYSA-N vetivazulene Chemical compound C1=CC=C(C)C2=CC(C(C)C)=CC2=C1C APVKGMMYGFJZHY-UHFFFAOYSA-N 0.000 description 2
- 229940117958 vinyl acetate Drugs 0.000 description 2
- 235000019155 vitamin A Nutrition 0.000 description 2
- 239000011719 vitamin A Substances 0.000 description 2
- NCYCYZXNIZJOKI-UHFFFAOYSA-N vitamin A aldehyde Natural products O=CC=C(C)C=CC=C(C)C=CC1=C(C)CCCC1(C)C NCYCYZXNIZJOKI-UHFFFAOYSA-N 0.000 description 2
- 229940045997 vitamin a Drugs 0.000 description 2
- 239000000341 volatile oil Substances 0.000 description 2
- 239000008307 w/o/w-emulsion Substances 0.000 description 2
- 238000005406 washing Methods 0.000 description 2
- 229920001285 xanthan gum Polymers 0.000 description 2
- 239000000230 xanthan gum Substances 0.000 description 2
- 235000010493 xanthan gum Nutrition 0.000 description 2
- 229940082509 xanthan gum Drugs 0.000 description 2
- ZFNVDHOSLNRHNN-UHFFFAOYSA-N xi-3-(4-Isopropylphenyl)-2-methylpropanal Chemical compound O=CC(C)CC1=CC=C(C(C)C)C=C1 ZFNVDHOSLNRHNN-UHFFFAOYSA-N 0.000 description 2
- 239000011787 zinc oxide Substances 0.000 description 2
- GVJHHUAWPYXKBD-IEOSBIPESA-N α-tocopherol Chemical compound OC1=C(C)C(C)=C2O[C@@](CCC[C@H](C)CCC[C@H](C)CCCC(C)C)(C)CCC2=C1C GVJHHUAWPYXKBD-IEOSBIPESA-N 0.000 description 2
- WTVHAMTYZJGJLJ-UHFFFAOYSA-N (+)-(4S,8R)-8-epi-beta-bisabolol Natural products CC(C)=CCCC(C)C1(O)CCC(C)=CC1 WTVHAMTYZJGJLJ-UHFFFAOYSA-N 0.000 description 1
- NOOLISFMXDJSKH-UTLUCORTSA-N (+)-Neomenthol Chemical compound CC(C)[C@@H]1CC[C@@H](C)C[C@@H]1O NOOLISFMXDJSKH-UTLUCORTSA-N 0.000 description 1
- RGZSQWQPBWRIAQ-CABCVRRESA-N (-)-alpha-Bisabolol Chemical compound CC(C)=CCC[C@](C)(O)[C@H]1CCC(C)=CC1 RGZSQWQPBWRIAQ-CABCVRRESA-N 0.000 description 1
- KZJWDPNRJALLNS-VPUBHVLGSA-N (-)-beta-Sitosterol Natural products O[C@@H]1CC=2[C@@](C)([C@@H]3[C@H]([C@H]4[C@@](C)([C@H]([C@H](CC[C@@H](C(C)C)CC)C)CC4)CC3)CC=2)CC1 KZJWDPNRJALLNS-VPUBHVLGSA-N 0.000 description 1
- BQPPJGMMIYJVBR-UHFFFAOYSA-N (10S)-3c-Acetoxy-4.4.10r.13c.14t-pentamethyl-17c-((R)-1.5-dimethyl-hexen-(4)-yl)-(5tH)-Delta8-tetradecahydro-1H-cyclopenta[a]phenanthren Natural products CC12CCC(OC(C)=O)C(C)(C)C1CCC1=C2CCC2(C)C(C(CCC=C(C)C)C)CCC21C BQPPJGMMIYJVBR-UHFFFAOYSA-N 0.000 description 1
- BITHHVVYSMSWAG-KTKRTIGZSA-N (11Z)-icos-11-enoic acid Chemical compound CCCCCCCC\C=C/CCCCCCCCCC(O)=O BITHHVVYSMSWAG-KTKRTIGZSA-N 0.000 description 1
- CFOQKXQWGLAKSK-KTKRTIGZSA-N (13Z)-docosen-1-ol Chemical compound CCCCCCCC\C=C/CCCCCCCCCCCCO CFOQKXQWGLAKSK-KTKRTIGZSA-N 0.000 description 1
- BOGBSWULIMKNSB-UHFFFAOYSA-N (2-amino-3-hydroxyphenyl)-phenylmethanone Chemical compound NC1=C(O)C=CC=C1C(=O)C1=CC=CC=C1 BOGBSWULIMKNSB-UHFFFAOYSA-N 0.000 description 1
- CRDAMVZIKSXKFV-FBXUGWQNSA-N (2-cis,6-cis)-farnesol Chemical compound CC(C)=CCC\C(C)=C/CC\C(C)=C/CO CRDAMVZIKSXKFV-FBXUGWQNSA-N 0.000 description 1
- ZHWLEUGSDGROJS-UHFFFAOYSA-N (2-tert-butylcyclohexyl) ethyl carbonate Chemical compound CCOC(=O)OC1CCCCC1C(C)(C)C ZHWLEUGSDGROJS-UHFFFAOYSA-N 0.000 description 1
- CSVWWLUMXNHWSU-UHFFFAOYSA-N (22E)-(24xi)-24-ethyl-5alpha-cholest-22-en-3beta-ol Natural products C1CC2CC(O)CCC2(C)C2C1C1CCC(C(C)C=CC(CC)C(C)C)C1(C)CC2 CSVWWLUMXNHWSU-UHFFFAOYSA-N 0.000 description 1
- OILXMJHPFNGGTO-UHFFFAOYSA-N (22E)-(24xi)-24-methylcholesta-5,22-dien-3beta-ol Natural products C1C=C2CC(O)CCC2(C)C2C1C1CCC(C(C)C=CC(C)C(C)C)C1(C)CC2 OILXMJHPFNGGTO-UHFFFAOYSA-N 0.000 description 1
- 239000000260 (2E,6E)-3,7,11-trimethyldodeca-2,6,10-trien-1-ol Substances 0.000 description 1
- OBETXYAYXDNJHR-SSDOTTSWSA-M (2r)-2-ethylhexanoate Chemical compound CCCC[C@@H](CC)C([O-])=O OBETXYAYXDNJHR-SSDOTTSWSA-M 0.000 description 1
- HSINOMROUCMIEA-FGVHQWLLSA-N (2s,4r)-4-[(3r,5s,6r,7r,8s,9s,10s,13r,14s,17r)-6-ethyl-3,7-dihydroxy-10,13-dimethyl-2,3,4,5,6,7,8,9,11,12,14,15,16,17-tetradecahydro-1h-cyclopenta[a]phenanthren-17-yl]-2-methylpentanoic acid Chemical compound C([C@@]12C)C[C@@H](O)C[C@H]1[C@@H](CC)[C@@H](O)[C@@H]1[C@@H]2CC[C@]2(C)[C@@H]([C@H](C)C[C@H](C)C(O)=O)CC[C@H]21 HSINOMROUCMIEA-FGVHQWLLSA-N 0.000 description 1
- FEOHYDSNGHIXOM-WLDMJGECSA-N (3R,4R,5S,6R)-3-amino-6-(hydroxymethyl)-2-methyloxane-2,4,5-triol Chemical compound CC1(O)[C@H](N)[C@@H](O)[C@H](O)[C@H](O1)CO FEOHYDSNGHIXOM-WLDMJGECSA-N 0.000 description 1
- 239000001147 (3aR,5aS,9aS,9bR)-3a,6,6,9a-tetramethyl-2,4,5,5a,7,8,9,9b-octahydro-1H-benzo[e][1]benzofuran Substances 0.000 description 1
- CHGIKSSZNBCNDW-UHFFFAOYSA-N (3beta,5alpha)-4,4-Dimethylcholesta-8,24-dien-3-ol Natural products CC12CCC(O)C(C)(C)C1CCC1=C2CCC2(C)C(C(CCC=C(C)C)C)CCC21 CHGIKSSZNBCNDW-UHFFFAOYSA-N 0.000 description 1
- WEFHSZAZNMEWKJ-KEDVMYETSA-N (6Z,8E)-undeca-6,8,10-trien-2-one (6E,8E)-undeca-6,8,10-trien-2-one (6Z,8E)-undeca-6,8,10-trien-3-one (6E,8E)-undeca-6,8,10-trien-3-one (6Z,8E)-undeca-6,8,10-trien-4-one (6E,8E)-undeca-6,8,10-trien-4-one Chemical compound CCCC(=O)C\C=C\C=C\C=C.CCCC(=O)C\C=C/C=C/C=C.CCC(=O)CC\C=C\C=C\C=C.CCC(=O)CC\C=C/C=C/C=C.CC(=O)CCC\C=C\C=C\C=C.CC(=O)CCC\C=C/C=C/C=C WEFHSZAZNMEWKJ-KEDVMYETSA-N 0.000 description 1
- CUXYLFPMQMFGPL-UHFFFAOYSA-N (9Z,11E,13E)-9,11,13-Octadecatrienoic acid Natural products CCCCC=CC=CC=CCCCCCCCC(O)=O CUXYLFPMQMFGPL-UHFFFAOYSA-N 0.000 description 1
- 125000004916 (C1-C6) alkylcarbonyl group Chemical group 0.000 description 1
- KSEBMYQBYZTDHS-HWKANZROSA-M (E)-Ferulic acid Natural products COC1=CC(\C=C\C([O-])=O)=CC=C1O KSEBMYQBYZTDHS-HWKANZROSA-M 0.000 description 1
- YKSSSKBJDZDZTD-XVNBXDOJSA-N (E)-isoeugenyl benzyl ether Chemical compound COC1=CC(\C=C\C)=CC=C1OCC1=CC=CC=C1 YKSSSKBJDZDZTD-XVNBXDOJSA-N 0.000 description 1
- WUOACPNHFRMFPN-VIFPVBQESA-N (R)-(+)-alpha-terpineol Chemical compound CC1=CC[C@H](C(C)(C)O)CC1 WUOACPNHFRMFPN-VIFPVBQESA-N 0.000 description 1
- DSSYKIVIOFKYAU-XCBNKYQSSA-N (R)-camphor Chemical class C1C[C@@]2(C)C(=O)C[C@@H]1C2(C)C DSSYKIVIOFKYAU-XCBNKYQSSA-N 0.000 description 1
- IZFHEQBZOYJLPK-SSDOTTSWSA-N (R)-dihydrolipoic acid Chemical compound OC(=O)CCCC[C@@H](S)CCS IZFHEQBZOYJLPK-SSDOTTSWSA-N 0.000 description 1
- MIOPJNTWMNEORI-GMSGAONNSA-N (S)-camphorsulfonic acid Chemical compound C1C[C@@]2(CS(O)(=O)=O)C(=O)C[C@@H]1C2(C)C MIOPJNTWMNEORI-GMSGAONNSA-N 0.000 description 1
- OVVINEZSSVQLTB-NRQGAZJASA-N (Z)-octadec-9-enoic acid (2R,3S,4R,5R)-2,3,4,5,6-pentahydroxyhexanal Chemical compound OC[C@@H](O)[C@@H](O)[C@H](O)[C@@H](O)C=O.CCCCCCCC\C=C/CCCCCCCC(O)=O.CCCCCCCC\C=C/CCCCCCCC(O)=O OVVINEZSSVQLTB-NRQGAZJASA-N 0.000 description 1
- PSBDWGZCVUAZQS-UHFFFAOYSA-N (dimethylsulfonio)acetate Chemical compound C[S+](C)CC([O-])=O PSBDWGZCVUAZQS-UHFFFAOYSA-N 0.000 description 1
- MTVBNJVZZAQKRV-BJMVGYQFSA-N (e)-2-methyl-4-(2,2,3-trimethylcyclopent-3-en-1-yl)but-2-en-1-ol Chemical compound OCC(/C)=C/CC1CC=C(C)C1(C)C MTVBNJVZZAQKRV-BJMVGYQFSA-N 0.000 description 1
- DJYWKXYRGAMLRE-QXMHVHEDSA-N (z)-icos-9-en-1-ol Chemical compound CCCCCCCCCC\C=C/CCCCCCCCO DJYWKXYRGAMLRE-QXMHVHEDSA-N 0.000 description 1
- TVPWKOCQOFBNML-SEYXRHQNSA-N (z)-octadec-6-en-1-ol Chemical compound CCCCCCCCCCC\C=C/CCCCCO TVPWKOCQOFBNML-SEYXRHQNSA-N 0.000 description 1
- JYEUMXHLPRZUAT-UHFFFAOYSA-N 1,2,3-triazine Chemical compound C1=CN=NN=C1 JYEUMXHLPRZUAT-UHFFFAOYSA-N 0.000 description 1
- LDVVTQMJQSCDMK-UHFFFAOYSA-N 1,3-dihydroxypropan-2-yl formate Chemical compound OCC(CO)OC=O LDVVTQMJQSCDMK-UHFFFAOYSA-N 0.000 description 1
- RSWGJHLUYNHPMX-UHFFFAOYSA-N 1,4a-dimethyl-7-propan-2-yl-2,3,4,4b,5,6,10,10a-octahydrophenanthrene-1-carboxylic acid Chemical compound C12CCC(C(C)C)=CC2=CCC2C1(C)CCCC2(C)C(O)=O RSWGJHLUYNHPMX-UHFFFAOYSA-N 0.000 description 1
- VPKMGDRERYMTJX-CMDGGOBGSA-N 1-(2,6,6-Trimethyl-2-cyclohexen-1-yl)-1-penten-3-one Chemical compound CCC(=O)\C=C\C1C(C)=CCCC1(C)C VPKMGDRERYMTJX-CMDGGOBGSA-N 0.000 description 1
- CRIGTVCBMUKRSL-FNORWQNLSA-N 1-(2,6,6-trimethylcyclohex-2-en-1-yl)but-2-enone Chemical compound C\C=C\C(=O)C1C(C)=CCCC1(C)C CRIGTVCBMUKRSL-FNORWQNLSA-N 0.000 description 1
- CDXJLTUAWFHXNY-UHFFFAOYSA-N 1-(3-methylbutoxy)octane Chemical group CCCCCCCCOCCC(C)C CDXJLTUAWFHXNY-UHFFFAOYSA-N 0.000 description 1
- XFRVVPUIAFSTFO-UHFFFAOYSA-N 1-Tridecanol Chemical compound CCCCCCCCCCCCCO XFRVVPUIAFSTFO-UHFFFAOYSA-N 0.000 description 1
- LDMOEFOXLIZJOW-UHFFFAOYSA-N 1-dodecanesulfonic acid Chemical compound CCCCCCCCCCCCS(O)(=O)=O LDMOEFOXLIZJOW-UHFFFAOYSA-N 0.000 description 1
- OSSNTDFYBPYIEC-UHFFFAOYSA-N 1-ethenylimidazole Chemical compound C=CN1C=CN=C1 OSSNTDFYBPYIEC-UHFFFAOYSA-N 0.000 description 1
- KUTWKGLRMXBROO-UHFFFAOYSA-N 1-hexoxyoctane Chemical compound CCCCCCCCOCCCCCC KUTWKGLRMXBROO-UHFFFAOYSA-N 0.000 description 1
- HBXWUCXDUUJDRB-UHFFFAOYSA-N 1-octadecoxyoctadecane Chemical compound CCCCCCCCCCCCCCCCCCOCCCCCCCCCCCCCCCCCC HBXWUCXDUUJDRB-UHFFFAOYSA-N 0.000 description 1
- 239000001351 1-phenylethyl propanoate Substances 0.000 description 1
- FBJAGEQLOUPXHL-UHFFFAOYSA-N 1-sulfanylethanesulfonic acid Chemical compound CC(S)S(O)(=O)=O FBJAGEQLOUPXHL-UHFFFAOYSA-N 0.000 description 1
- XDDLRVYDQACVBC-UHFFFAOYSA-N 10-oxo-10-(1,2,2,6,6-pentamethylpiperidin-4-yl)oxydecanoic acid Chemical compound CN1C(C)(C)CC(OC(=O)CCCCCCCCC(O)=O)CC1(C)C XDDLRVYDQACVBC-UHFFFAOYSA-N 0.000 description 1
- HEJCZAMFVMNFLC-UHFFFAOYSA-N 10-oxo-10-(2,2,6,6-tetramethylpiperidin-4-yl)oxydecanoic acid Chemical compound CC1(C)CC(OC(=O)CCCCCCCCC(O)=O)CC(C)(C)N1 HEJCZAMFVMNFLC-UHFFFAOYSA-N 0.000 description 1
- CFOQKXQWGLAKSK-UHFFFAOYSA-N 13-docosen-1-ol Natural products CCCCCCCCC=CCCCCCCCCCCCCO CFOQKXQWGLAKSK-UHFFFAOYSA-N 0.000 description 1
- XYTLYKGXLMKYMV-UHFFFAOYSA-N 14alpha-methylzymosterol Natural products CC12CCC(O)CC1CCC1=C2CCC2(C)C(C(CCC=C(C)C)C)CCC21C XYTLYKGXLMKYMV-UHFFFAOYSA-N 0.000 description 1
- ICOPEORIQSTXSC-UHFFFAOYSA-N 16-methylheptadecanoic acid propane-1,2-diol Chemical class CC(O)CO.CC(C)CCCCCCCCCCCCCCC(O)=O ICOPEORIQSTXSC-UHFFFAOYSA-N 0.000 description 1
- FMMHUIFSJWVNAE-UHFFFAOYSA-N 1h-1,3-benzodiazepine Chemical class N1C=NC=CC2=CC=CC=C12 FMMHUIFSJWVNAE-UHFFFAOYSA-N 0.000 description 1
- ZZLQHXCRRMUGQJ-UHFFFAOYSA-N 2'-Hydroxyflavone Chemical compound OC1=CC=CC=C1C1=CC(=O)C2=CC=CC=C2O1 ZZLQHXCRRMUGQJ-UHFFFAOYSA-N 0.000 description 1
- LTMRRSWNXVJMBA-UHFFFAOYSA-L 2,2-diethylpropanedioate Chemical compound CCC(CC)(C([O-])=O)C([O-])=O LTMRRSWNXVJMBA-UHFFFAOYSA-L 0.000 description 1
- UZBOWOQARWWIER-UHFFFAOYSA-N 2,2-dimethyl-5-oxooxolane-3-carboxylic acid Chemical compound CC1(C)OC(=O)CC1C(O)=O UZBOWOQARWWIER-UHFFFAOYSA-N 0.000 description 1
- JNAYPSWVMNJOPQ-UHFFFAOYSA-N 2,3-bis(16-methylheptadecanoyloxy)propyl 16-methylheptadecanoate Chemical compound CC(C)CCCCCCCCCCCCCCC(=O)OCC(OC(=O)CCCCCCCCCCCCCCC(C)C)COC(=O)CCCCCCCCCCCCCCC(C)C JNAYPSWVMNJOPQ-UHFFFAOYSA-N 0.000 description 1
- BXXWFOGWXLJPPA-UHFFFAOYSA-N 2,3-dibromobutane Chemical compound CC(Br)C(C)Br BXXWFOGWXLJPPA-UHFFFAOYSA-N 0.000 description 1
- PWVUXRBUUYZMKM-UHFFFAOYSA-N 2-(2-hydroxyethoxy)ethyl octadecanoate Chemical compound CCCCCCCCCCCCCCCCCC(=O)OCCOCCO PWVUXRBUUYZMKM-UHFFFAOYSA-N 0.000 description 1
- SMZOUWXMTYCWNB-UHFFFAOYSA-N 2-(2-methoxy-5-methylphenyl)ethanamine Chemical compound COC1=CC=C(C)C=C1CCN SMZOUWXMTYCWNB-UHFFFAOYSA-N 0.000 description 1
- DNRJTBAOUJJKDY-UHFFFAOYSA-N 2-Acetyl-3,5,5,6,8,8-hexamethyl-5,6,7,8- tetrahydronaphthalene Chemical compound CC(=O)C1=C(C)C=C2C(C)(C)C(C)CC(C)(C)C2=C1 DNRJTBAOUJJKDY-UHFFFAOYSA-N 0.000 description 1
- KIHBGTRZFAVZRV-UHFFFAOYSA-N 2-Hydroxyoctadecanoic acid Natural products CCCCCCCCCCCCCCCCC(O)C(O)=O KIHBGTRZFAVZRV-UHFFFAOYSA-N 0.000 description 1
- TURPNXCLLLFJAP-UHFFFAOYSA-N 2-[2-(2-hydroxyethoxy)ethoxy]ethyl hydrogen sulfate Chemical compound OCCOCCOCCOS(O)(=O)=O TURPNXCLLLFJAP-UHFFFAOYSA-N 0.000 description 1
- PMRTXCQELXDQEH-UHFFFAOYSA-N 2-[carboxymethyl-[2-oxo-2-(2,2,6,6-tetramethylpiperidin-4-yl)oxyethyl]amino]acetic acid Chemical compound CC1(C)CC(OC(=O)CN(CC(O)=O)CC(O)=O)CC(C)(C)N1 PMRTXCQELXDQEH-UHFFFAOYSA-N 0.000 description 1
- UXFQFBNBSPQBJW-UHFFFAOYSA-N 2-amino-2-methylpropane-1,3-diol Chemical compound OCC(N)(C)CO UXFQFBNBSPQBJW-UHFFFAOYSA-N 0.000 description 1
- RJFAYQIBOAGBLC-UHFFFAOYSA-N 2-amino-4-methylselanyl-butanoic acid Chemical compound C[Se]CCC(N)C(O)=O RJFAYQIBOAGBLC-UHFFFAOYSA-N 0.000 description 1
- 125000000022 2-aminoethyl group Chemical group [H]C([*])([H])C([H])([H])N([H])[H] 0.000 description 1
- ABBAQSIKFAPOHH-UHFFFAOYSA-N 2-butyl-2-[(4-hydroxyphenyl)methyl]propanedioic acid Chemical group CCCCC(C(O)=O)(C(O)=O)CC1=CC=C(O)C=C1 ABBAQSIKFAPOHH-UHFFFAOYSA-N 0.000 description 1
- IJVRPNIWWODHHA-UHFFFAOYSA-N 2-cyanoprop-2-enoic acid Chemical compound OC(=O)C(=C)C#N IJVRPNIWWODHHA-UHFFFAOYSA-N 0.000 description 1
- OSCJHTSDLYVCQC-UHFFFAOYSA-N 2-ethylhexyl 4-[[4-[4-(tert-butylcarbamoyl)anilino]-6-[4-(2-ethylhexoxycarbonyl)anilino]-1,3,5-triazin-2-yl]amino]benzoate Chemical compound C1=CC(C(=O)OCC(CC)CCCC)=CC=C1NC1=NC(NC=2C=CC(=CC=2)C(=O)NC(C)(C)C)=NC(NC=2C=CC(=CC=2)C(=O)OCC(CC)CCCC)=N1 OSCJHTSDLYVCQC-UHFFFAOYSA-N 0.000 description 1
- NPSJHQMIVNJLNN-UHFFFAOYSA-N 2-ethylhexyl 4-nitrobenzoate Chemical compound CCCCC(CC)COC(=O)C1=CC=C([N+]([O-])=O)C=C1 NPSJHQMIVNJLNN-UHFFFAOYSA-N 0.000 description 1
- OPJWPPVYCOPDCM-UHFFFAOYSA-N 2-ethylhexyl octadecanoate Chemical compound CCCCCCCCCCCCCCCCCC(=O)OCC(CC)CCCC OPJWPPVYCOPDCM-UHFFFAOYSA-N 0.000 description 1
- 239000004808 2-ethylhexylester Substances 0.000 description 1
- IMQYZLJIDNYQLX-UHFFFAOYSA-N 2-hydroxy-4-octadecoxy-2-(2-octadecoxy-2-oxoethyl)-4-oxobutanoic acid Chemical compound CCCCCCCCCCCCCCCCCCOC(=O)CC(O)(C(O)=O)CC(=O)OCCCCCCCCCCCCCCCCCC IMQYZLJIDNYQLX-UHFFFAOYSA-N 0.000 description 1
- BKOOMYPCSUNDGP-UHFFFAOYSA-N 2-methylbut-2-ene Chemical compound CC=C(C)C BKOOMYPCSUNDGP-UHFFFAOYSA-N 0.000 description 1
- ZKYCLDTVJCJYIB-UHFFFAOYSA-N 2-methylidenedecanamide Chemical compound CCCCCCCCC(=C)C(N)=O ZKYCLDTVJCJYIB-UHFFFAOYSA-N 0.000 description 1
- ILPBINAXDRFYPL-UHFFFAOYSA-N 2-octene Chemical compound CCCCCC=CC ILPBINAXDRFYPL-UHFFFAOYSA-N 0.000 description 1
- QJGNSTCICFBACB-UHFFFAOYSA-N 2-octylpropanedioic acid Chemical class CCCCCCCCC(C(O)=O)C(O)=O QJGNSTCICFBACB-UHFFFAOYSA-N 0.000 description 1
- ISDGWTZFJKFKMO-UHFFFAOYSA-N 2-phenyl-1,3-dioxane-4,6-dione Chemical compound O1C(=O)CC(=O)OC1C1=CC=CC=C1 ISDGWTZFJKFKMO-UHFFFAOYSA-N 0.000 description 1
- WLJVXDMOQOGPHL-PPJXEINESA-N 2-phenylacetic acid Chemical compound O[14C](=O)CC1=CC=CC=C1 WLJVXDMOQOGPHL-PPJXEINESA-N 0.000 description 1
- KLEXDBGYSOIREE-UHFFFAOYSA-N 24xi-n-propylcholesterol Natural products C1C=C2CC(O)CCC2(C)C2C1C1CCC(C(C)CCC(CCC)C(C)C)C1(C)CC2 KLEXDBGYSOIREE-UHFFFAOYSA-N 0.000 description 1
- YLGCZMOAYIGIPX-UHFFFAOYSA-N 3,6-dimethylcyclohex-3-ene-1-carbaldehyde Chemical compound CC1CC=C(C)CC1C=O YLGCZMOAYIGIPX-UHFFFAOYSA-N 0.000 description 1
- ACGQRMRFZCXYHQ-UHFFFAOYSA-N 3-[2-(2-aminoethylamino)ethyl-(dimethylamino)amino]propan-1-ol Chemical class OCCCN(N(C)C)CCNCCN ACGQRMRFZCXYHQ-UHFFFAOYSA-N 0.000 description 1
- UWRBFYBQPCJRRL-UHFFFAOYSA-N 3-[bis(carboxymethyl)amino]propanoic acid Chemical compound OC(=O)CCN(CC(O)=O)CC(O)=O UWRBFYBQPCJRRL-UHFFFAOYSA-N 0.000 description 1
- QJZYHAIUNVAGQP-UHFFFAOYSA-N 3-nitrobicyclo[2.2.1]hept-5-ene-2,3-dicarboxylic acid Chemical compound C1C2C=CC1C(C(=O)O)C2(C(O)=O)[N+]([O-])=O QJZYHAIUNVAGQP-UHFFFAOYSA-N 0.000 description 1
- FPTJELQXIUUCEY-UHFFFAOYSA-N 3beta-Hydroxy-lanostan Natural products C1CC2C(C)(C)C(O)CCC2(C)C2C1C1(C)CCC(C(C)CCCC(C)C)C1(C)CC2 FPTJELQXIUUCEY-UHFFFAOYSA-N 0.000 description 1
- RKZIPFOHRUCGGS-UHFFFAOYSA-N 4,5-dihydroimidazole-1-carboxylic acid Chemical compound OC(=O)N1CCN=C1 RKZIPFOHRUCGGS-UHFFFAOYSA-N 0.000 description 1
- ORMHZBNNECIKOH-UHFFFAOYSA-N 4-(4-hydroxy-4-methylpentyl)cyclohex-3-ene-1-carbaldehyde Chemical compound CC(C)(O)CCCC1=CCC(C=O)CC1 ORMHZBNNECIKOH-UHFFFAOYSA-N 0.000 description 1
- YDIYEOMDOWUDTJ-UHFFFAOYSA-N 4-(dimethylamino)benzoic acid Chemical compound CN(C)C1=CC=C(C(O)=O)C=C1 YDIYEOMDOWUDTJ-UHFFFAOYSA-N 0.000 description 1
- XWNSFEAWWGGSKJ-UHFFFAOYSA-N 4-acetyl-4-methylheptanedinitrile Chemical compound N#CCCC(C)(C(=O)C)CCC#N XWNSFEAWWGGSKJ-UHFFFAOYSA-N 0.000 description 1
- SDYBESKQYHZQMA-UHFFFAOYSA-N 4-butyl-2,2,6,6-tetramethylpiperidin-1-amine Chemical class CCCCC1CC(C)(C)N(N)C(C)(C)C1 SDYBESKQYHZQMA-UHFFFAOYSA-N 0.000 description 1
- HIQIXEFWDLTDED-UHFFFAOYSA-N 4-hydroxy-1-piperidin-4-ylpyrrolidin-2-one Chemical compound O=C1CC(O)CN1C1CCNCC1 HIQIXEFWDLTDED-UHFFFAOYSA-N 0.000 description 1
- GHUDTURWNYDCKX-UHFFFAOYSA-N 4-oxo-4-(2,2,6,6-tetramethylpiperidin-4-yl)oxybutanoic acid Chemical compound CC1(C)CC(OC(=O)CCC(O)=O)CC(C)(C)N1 GHUDTURWNYDCKX-UHFFFAOYSA-N 0.000 description 1
- JKTORXLUQLQJCM-UHFFFAOYSA-N 4-phosphonobutylphosphonic acid Chemical compound OP(O)(=O)CCCCP(O)(O)=O JKTORXLUQLQJCM-UHFFFAOYSA-N 0.000 description 1
- MYMNBFURSYZQBR-UHFFFAOYSA-N 5-ethoxy-5-oxopentanoic acid Chemical compound CCOC(=O)CCCC(O)=O MYMNBFURSYZQBR-UHFFFAOYSA-N 0.000 description 1
- IUFQZPBIRYFPFD-UHFFFAOYSA-N 5-ethyl-3-hydroxy-4-methyl-2(5H)-furanone Chemical compound CCC1OC(=O)C(O)=C1C IUFQZPBIRYFPFD-UHFFFAOYSA-N 0.000 description 1
- FHVDTGUDJYJELY-UHFFFAOYSA-N 6-{[2-carboxy-4,5-dihydroxy-6-(phosphanyloxy)oxan-3-yl]oxy}-4,5-dihydroxy-3-phosphanyloxane-2-carboxylic acid Chemical compound O1C(C(O)=O)C(P)C(O)C(O)C1OC1C(C(O)=O)OC(OP)C(O)C1O FHVDTGUDJYJELY-UHFFFAOYSA-N 0.000 description 1
- OQMZNAMGEHIHNN-UHFFFAOYSA-N 7-Dehydrostigmasterol Natural products C1C(O)CCC2(C)C(CCC3(C(C(C)C=CC(CC)C(C)C)CCC33)C)C3=CC=C21 OQMZNAMGEHIHNN-UHFFFAOYSA-N 0.000 description 1
- YWWVWXASSLXJHU-UHFFFAOYSA-N 9E-tetradecenoic acid Natural products CCCCC=CCCCCCCCC(O)=O YWWVWXASSLXJHU-UHFFFAOYSA-N 0.000 description 1
- 244000020998 Acacia farnesiana Species 0.000 description 1
- 235000003074 Acacia farnesiana Nutrition 0.000 description 1
- QTBSBXVTEAMEQO-UHFFFAOYSA-M Acetate Chemical compound CC([O-])=O QTBSBXVTEAMEQO-UHFFFAOYSA-M 0.000 description 1
- HRPVXLWXLXDGHG-UHFFFAOYSA-N Acrylamide Chemical compound NC(=O)C=C HRPVXLWXLXDGHG-UHFFFAOYSA-N 0.000 description 1
- 229920001817 Agar Polymers 0.000 description 1
- 235000019489 Almond oil Nutrition 0.000 description 1
- 244000144730 Amygdalus persica Species 0.000 description 1
- 108010085443 Anserine Proteins 0.000 description 1
- 235000003092 Artemisia dracunculus Nutrition 0.000 description 1
- 240000001851 Artemisia dracunculus Species 0.000 description 1
- GWZYPXHJIZCRAJ-UHFFFAOYSA-N Biliverdin Natural products CC1=C(C=C)C(=C/C2=NC(=Cc3[nH]c(C=C/4NC(=O)C(=C4C)C=C)c(C)c3CCC(=O)O)C(=C2C)CCC(=O)O)NC1=O GWZYPXHJIZCRAJ-UHFFFAOYSA-N 0.000 description 1
- RCNSAJSGRJSBKK-NSQVQWHSSA-N Biliverdin IX Chemical compound N1C(=O)C(C)=C(C=C)\C1=C\C1=C(C)C(CCC(O)=O)=C(\C=C/2C(=C(C)C(=C/C=3C(=C(C=C)C(=O)N=3)C)/N\2)CCC(O)=O)N1 RCNSAJSGRJSBKK-NSQVQWHSSA-N 0.000 description 1
- JMGZEFIQIZZSBH-UHFFFAOYSA-N Bioquercetin Natural products CC1OC(OCC(O)C2OC(OC3=C(Oc4cc(O)cc(O)c4C3=O)c5ccc(O)c(O)c5)C(O)C2O)C(O)C(O)C1O JMGZEFIQIZZSBH-UHFFFAOYSA-N 0.000 description 1
- 239000004255 Butylated hydroxyanisole Substances 0.000 description 1
- 239000004322 Butylated hydroxytoluene Substances 0.000 description 1
- NLZUEZXRPGMBCV-UHFFFAOYSA-N Butylhydroxytoluene Chemical compound CC1=CC(C(C)(C)C)=C(O)C(C(C)(C)C)=C1 NLZUEZXRPGMBCV-UHFFFAOYSA-N 0.000 description 1
- FERIUCNNQQJTOY-UHFFFAOYSA-N Butyric acid Natural products CCCC(O)=O FERIUCNNQQJTOY-UHFFFAOYSA-N 0.000 description 1
- RWFQWIHFWRHDTA-UHFFFAOYSA-N C(CCC)(O)O.C(CCCCCCCCCCCCCCC(C)C)(=O)O Chemical class C(CCC)(O)O.C(CCCCCCCCCCCCCCC(C)C)(=O)O RWFQWIHFWRHDTA-UHFFFAOYSA-N 0.000 description 1
- YXYKIXHQDOQFFJ-UHFFFAOYSA-N C(CCCCCCCCCCC)ON(C1=CC=CC=C1)OCCCCCCCCCCCCCC Chemical compound C(CCCCCCCCCCC)ON(C1=CC=CC=C1)OCCCCCCCCCCCCCC YXYKIXHQDOQFFJ-UHFFFAOYSA-N 0.000 description 1
- 125000002853 C1-C4 hydroxyalkyl group Chemical group 0.000 description 1
- YDNKGFDKKRUKPY-JHOUSYSJSA-N C16 ceramide Natural products CCCCCCCCCCCCCCCC(=O)N[C@@H](CO)[C@H](O)C=CCCCCCCCCCCCCC YDNKGFDKKRUKPY-JHOUSYSJSA-N 0.000 description 1
- FCZFVKBICRRBFH-UHFFFAOYSA-N CC(=O)C(CC1=CC=CC=C1)CC2=CC(=C(C=C2)O)OC Chemical compound CC(=O)C(CC1=CC=CC=C1)CC2=CC(=C(C=C2)O)OC FCZFVKBICRRBFH-UHFFFAOYSA-N 0.000 description 1
- NOKXNDKMAPFVBB-UHFFFAOYSA-N CC(C)[Ti] Chemical compound CC(C)[Ti] NOKXNDKMAPFVBB-UHFFFAOYSA-N 0.000 description 1
- YFKTWWJKGDLJDH-UHFFFAOYSA-N CC(O)CO.CCCCCCCCC(O)=O Chemical class CC(O)CO.CCCCCCCCC(O)=O YFKTWWJKGDLJDH-UHFFFAOYSA-N 0.000 description 1
- MLOCEVRFZHPNPT-LATCQUSVSA-N CCCCCCCCCC\C=C/CCCCCCCC(O)=O.CCCCCCCCCCCCCCCCCCCCCC(O)=O Chemical compound CCCCCCCCCC\C=C/CCCCCCCC(O)=O.CCCCCCCCCCCCCCCCCCCCCC(O)=O MLOCEVRFZHPNPT-LATCQUSVSA-N 0.000 description 1
- 241000722685 Callitris rhomboidea Species 0.000 description 1
- SGNBVLSWZMBQTH-FGAXOLDCSA-N Campesterol Natural products O[C@@H]1CC=2[C@@](C)([C@@H]3[C@H]([C@H]4[C@@](C)([C@H]([C@H](CC[C@H](C(C)C)C)C)CC4)CC3)CC=2)CC1 SGNBVLSWZMBQTH-FGAXOLDCSA-N 0.000 description 1
- 235000007571 Cananga odorata Nutrition 0.000 description 1
- 240000007436 Cananga odorata Species 0.000 description 1
- 241000644798 Canarium <sea snail> Species 0.000 description 1
- 240000005209 Canarium indicum Species 0.000 description 1
- 244000025254 Cannabis sativa Species 0.000 description 1
- 239000004215 Carbon black (E152) Substances 0.000 description 1
- 229920002134 Carboxymethyl cellulose Polymers 0.000 description 1
- QRYRORQUOLYVBU-VBKZILBWSA-N Carnosic acid Natural products CC([C@@H]1CC2)(C)CCC[C@]1(C(O)=O)C1=C2C=C(C(C)C)C(O)=C1O QRYRORQUOLYVBU-VBKZILBWSA-N 0.000 description 1
- 241001090476 Castoreum Species 0.000 description 1
- 241000218645 Cedrus Species 0.000 description 1
- 229920013683 Celanese Polymers 0.000 description 1
- 229920002101 Chitin Polymers 0.000 description 1
- GHXZTYHSJHQHIJ-UHFFFAOYSA-N Chlorhexidine Chemical compound C=1C=C(Cl)C=CC=1NC(N)=NC(N)=NCCCCCCN=C(N)N=C(N)NC1=CC=C(Cl)C=C1 GHXZTYHSJHQHIJ-UHFFFAOYSA-N 0.000 description 1
- VEXZGXHMUGYJMC-UHFFFAOYSA-M Chloride anion Chemical compound [Cl-] VEXZGXHMUGYJMC-UHFFFAOYSA-M 0.000 description 1
- WTEVQBCEXWBHNA-UHFFFAOYSA-N Citral Natural products CC(C)=CCCC(C)=CC=O WTEVQBCEXWBHNA-UHFFFAOYSA-N 0.000 description 1
- LPZCCMIISIBREI-MTFRKTCUSA-N Citrostadienol Natural products CC=C(CC[C@@H](C)[C@H]1CC[C@H]2C3=CC[C@H]4[C@H](C)[C@@H](O)CC[C@]4(C)[C@H]3CC[C@]12C)C(C)C LPZCCMIISIBREI-MTFRKTCUSA-N 0.000 description 1
- 241000675108 Citrus tangerina Species 0.000 description 1
- ACTIUHUUMQJHFO-UHFFFAOYSA-N Coenzym Q10 Natural products COC1=C(OC)C(=O)C(CC=C(C)CCC=C(C)CCC=C(C)CCC=C(C)CCC=C(C)CCC=C(C)CCC=C(C)CCC=C(C)CCC=C(C)CCC=C(C)C)=C(C)C1=O ACTIUHUUMQJHFO-UHFFFAOYSA-N 0.000 description 1
- LAAPRQODJPXAHC-UHFFFAOYSA-N Coniferyl benzoate Natural products C1=C(O)C(OC)=CC(C=CCOC(=O)C=2C=CC=CC=2)=C1 LAAPRQODJPXAHC-UHFFFAOYSA-N 0.000 description 1
- 235000002787 Coriandrum sativum Nutrition 0.000 description 1
- 244000018436 Coriandrum sativum Species 0.000 description 1
- 244000007835 Cyamopsis tetragonoloba Species 0.000 description 1
- XDTMQSROBMDMFD-UHFFFAOYSA-N Cyclohexane Chemical compound C1CCCCC1 XDTMQSROBMDMFD-UHFFFAOYSA-N 0.000 description 1
- FBPFZTCFMRRESA-KVTDHHQDSA-N D-Mannitol Chemical compound OC[C@@H](O)[C@@H](O)[C@H](O)[C@H](O)CO FBPFZTCFMRRESA-KVTDHHQDSA-N 0.000 description 1
- ZZZCUOFIHGPKAK-UHFFFAOYSA-N D-erythro-ascorbic acid Natural products OCC1OC(=O)C(O)=C1O ZZZCUOFIHGPKAK-UHFFFAOYSA-N 0.000 description 1
- WQZGKKKJIJFFOK-QTVWNMPRSA-N D-mannopyranose Chemical compound OC[C@H]1OC(O)[C@@H](O)[C@@H](O)[C@@H]1O WQZGKKKJIJFFOK-QTVWNMPRSA-N 0.000 description 1
- NOOLISFMXDJSKH-UHFFFAOYSA-N DL-menthol Natural products CC(C)C1CCC(C)CC1O NOOLISFMXDJSKH-UHFFFAOYSA-N 0.000 description 1
- 208000001840 Dandruff Diseases 0.000 description 1
- ARVGMISWLZPBCH-UHFFFAOYSA-N Dehydro-beta-sitosterol Natural products C1C(O)CCC2(C)C(CCC3(C(C(C)CCC(CC)C(C)C)CCC33)C)C3=CC=C21 ARVGMISWLZPBCH-UHFFFAOYSA-N 0.000 description 1
- FEWJPZIEWOKRBE-JCYAYHJZSA-N Dextrotartaric acid Chemical compound OC(=O)[C@H](O)[C@@H](O)C(O)=O FEWJPZIEWOKRBE-JCYAYHJZSA-N 0.000 description 1
- XTJFFFGAUHQWII-UHFFFAOYSA-N Dibutyl adipate Chemical compound CCCCOC(=O)CCCCC(=O)OCCCC XTJFFFGAUHQWII-UHFFFAOYSA-N 0.000 description 1
- AQZGPSLYZOOYQP-UHFFFAOYSA-N Diisoamyl ether Chemical compound CC(C)CCOCCC(C)C AQZGPSLYZOOYQP-UHFFFAOYSA-N 0.000 description 1
- 239000003508 Dilauryl thiodipropionate Substances 0.000 description 1
- 239000002656 Distearyl thiodipropionate Substances 0.000 description 1
- GZZPOFFXKUVNSW-UHFFFAOYSA-N Dodecenoic acid Natural products OC(=O)CCCCCCCCCC=C GZZPOFFXKUVNSW-UHFFFAOYSA-N 0.000 description 1
- 235000018602 Elettaria cardamomum Nutrition 0.000 description 1
- 240000002943 Elettaria cardamomum Species 0.000 description 1
- BRLQWZUYTZBJKN-UHFFFAOYSA-N Epichlorohydrin Chemical compound ClCC1CO1 BRLQWZUYTZBJKN-UHFFFAOYSA-N 0.000 description 1
- YXAGIRHBJJLWHW-UHFFFAOYSA-N Ethyl 2-ethylhexanoate Chemical group CCCCC(CC)C(=O)OCC YXAGIRHBJJLWHW-UHFFFAOYSA-N 0.000 description 1
- FPVVYTCTZKCSOJ-UHFFFAOYSA-N Ethylene glycol distearate Chemical compound CCCCCCCCCCCCCCCCCC(=O)OCCOC(=O)CCCCCCCCCCCCCCCCC FPVVYTCTZKCSOJ-UHFFFAOYSA-N 0.000 description 1
- FMRHJJZUHUTGKE-UHFFFAOYSA-N Ethylhexyl salicylate Chemical compound CCCCC(CC)COC(=O)C1=CC=CC=C1O FMRHJJZUHUTGKE-UHFFFAOYSA-N 0.000 description 1
- 241000116713 Ferula gummosa Species 0.000 description 1
- 241000206672 Gelidium Species 0.000 description 1
- YXHVCZZLWZYHSA-FPLPWBNLSA-N Ginkgoic acid Chemical compound CCCCCC\C=C/CCCCCCCC1=CC=CC(O)=C1C(O)=O YXHVCZZLWZYHSA-FPLPWBNLSA-N 0.000 description 1
- BKLIAINBCQPSOV-UHFFFAOYSA-N Gluanol Natural products CC(C)CC=CC(C)C1CCC2(C)C3=C(CCC12C)C4(C)CCC(O)C(C)(C)C4CC3 BKLIAINBCQPSOV-UHFFFAOYSA-N 0.000 description 1
- 241000190019 Guaiacum Species 0.000 description 1
- 235000004440 Guaiacum sanctum Nutrition 0.000 description 1
- BTEISVKTSQLKST-UHFFFAOYSA-N Haliclonasterol Natural products CC(C=CC(C)C(C)(C)C)C1CCC2C3=CC=C4CC(O)CCC4(C)C3CCC12C BTEISVKTSQLKST-UHFFFAOYSA-N 0.000 description 1
- 241000282375 Herpestidae Species 0.000 description 1
- IMQLKJBTEOYOSI-GPIVLXJGSA-N Inositol-hexakisphosphate Chemical compound OP(O)(=O)O[C@H]1[C@H](OP(O)(O)=O)[C@@H](OP(O)(O)=O)[C@H](OP(O)(O)=O)[C@H](OP(O)(O)=O)[C@@H]1OP(O)(O)=O IMQLKJBTEOYOSI-GPIVLXJGSA-N 0.000 description 1
- 108090000723 Insulin-Like Growth Factor I Proteins 0.000 description 1
- BJIOGJUNALELMI-ONEGZZNKSA-N Isoeugenol Natural products COC1=CC(\C=C\C)=CC=C1O BJIOGJUNALELMI-ONEGZZNKSA-N 0.000 description 1
- 235000010254 Jasminum officinale Nutrition 0.000 description 1
- 240000005385 Jasminum sambac Species 0.000 description 1
- 244000162475 Juniperus rigida Species 0.000 description 1
- 235000009069 Juniperus rigida Nutrition 0.000 description 1
- 241001446187 Kermes Species 0.000 description 1
- 102100039386 Ketimine reductase mu-crystallin Human genes 0.000 description 1
- MLSJBGYKDYSOAE-DCWMUDTNSA-N L-Ascorbic acid-2-glucoside Chemical compound OC[C@H](O)[C@H]1OC(=O)C(O[C@@H]2[C@@H]([C@@H](O)[C@H](O)[C@@H](CO)O2)O)=C1O MLSJBGYKDYSOAE-DCWMUDTNSA-N 0.000 description 1
- XUJNEKJLAYXESH-REOHCLBHSA-N L-Cysteine Chemical compound SC[C@H](N)C(O)=O XUJNEKJLAYXESH-REOHCLBHSA-N 0.000 description 1
- SLRNWACWRVGMKD-UHFFFAOYSA-N L-anserine Natural products CN1C=NC(CC(NC(=O)CCN)C(O)=O)=C1 SLRNWACWRVGMKD-UHFFFAOYSA-N 0.000 description 1
- LEVWYRKDKASIDU-IMJSIDKUSA-N L-cystine Chemical compound [O-]C(=O)[C@@H]([NH3+])CSSC[C@H]([NH3+])C([O-])=O LEVWYRKDKASIDU-IMJSIDKUSA-N 0.000 description 1
- WHUUTDBJXJRKMK-VKHMYHEASA-N L-glutamic acid Chemical compound OC(=O)[C@@H](N)CCC(O)=O WHUUTDBJXJRKMK-VKHMYHEASA-N 0.000 description 1
- HNDVDQJCIGZPNO-YFKPBYRVSA-N L-histidine Chemical compound OC(=O)[C@@H](N)CC1=CN=CN1 HNDVDQJCIGZPNO-YFKPBYRVSA-N 0.000 description 1
- QIVBCDIJIAJPQS-VIFPVBQESA-N L-tryptophane Chemical compound C1=CC=C2C(C[C@H](N)C(O)=O)=CNC2=C1 QIVBCDIJIAJPQS-VIFPVBQESA-N 0.000 description 1
- OUYCCCASQSFEME-QMMMGPOBSA-N L-tyrosine Chemical compound OC(=O)[C@@H](N)CC1=CC=C(O)C=C1 OUYCCCASQSFEME-QMMMGPOBSA-N 0.000 description 1
- JVTAAEKCZFNVCJ-UHFFFAOYSA-M Lactate Chemical compound CC(O)C([O-])=O JVTAAEKCZFNVCJ-UHFFFAOYSA-M 0.000 description 1
- 102000010445 Lactoferrin Human genes 0.000 description 1
- 108010063045 Lactoferrin Proteins 0.000 description 1
- 239000004166 Lanolin Substances 0.000 description 1
- LOPKHWOTGJIQLC-UHFFFAOYSA-N Lanosterol Natural products CC(CCC=C(C)C)C1CCC2(C)C3=C(CCC12C)C4(C)CCC(C)(O)C(C)(C)C4CC3 LOPKHWOTGJIQLC-UHFFFAOYSA-N 0.000 description 1
- 235000017858 Laurus nobilis Nutrition 0.000 description 1
- 235000010663 Lavandula angustifolia Nutrition 0.000 description 1
- 244000178870 Lavandula angustifolia Species 0.000 description 1
- 102000004895 Lipoproteins Human genes 0.000 description 1
- 108090001030 Lipoproteins Proteins 0.000 description 1
- 101000772180 Lithobates catesbeianus Transthyretin Proteins 0.000 description 1
- JEVVKJMRZMXFBT-XWDZUXABSA-N Lycophyll Natural products OC/C(=C/CC/C(=C\C=C\C(=C/C=C/C(=C\C=C\C=C(/C=C/C=C(\C=C\C=C(/CC/C=C(/CO)\C)\C)/C)\C)/C)\C)/C)/C JEVVKJMRZMXFBT-XWDZUXABSA-N 0.000 description 1
- 229930195725 Mannitol Natural products 0.000 description 1
- 241001465754 Metazoa Species 0.000 description 1
- CERQOIWHTDAKMF-UHFFFAOYSA-N Methacrylic acid Chemical compound CC(=C)C(O)=O CERQOIWHTDAKMF-UHFFFAOYSA-N 0.000 description 1
- LSDPWZHWYPCBBB-UHFFFAOYSA-N Methanethiol Chemical compound SC LSDPWZHWYPCBBB-UHFFFAOYSA-N 0.000 description 1
- XOBKSJJDNFUZPF-UHFFFAOYSA-N Methoxyethane Chemical compound CCOC XOBKSJJDNFUZPF-UHFFFAOYSA-N 0.000 description 1
- VVQNEPGJFQJSBK-UHFFFAOYSA-N Methyl methacrylate Chemical compound COC(=O)C(C)=C VVQNEPGJFQJSBK-UHFFFAOYSA-N 0.000 description 1
- 244000179970 Monarda didyma Species 0.000 description 1
- 235000010672 Monarda didyma Nutrition 0.000 description 1
- 241001057584 Myrrha Species 0.000 description 1
- OVBPIULPVIDEAO-UHFFFAOYSA-N N-Pteroyl-L-glutaminsaeure Natural products C=1N=C2NC(N)=NC(=O)C2=NC=1CNC1=CC=C(C(=O)NC(CCC(O)=O)C(O)=O)C=C1 OVBPIULPVIDEAO-UHFFFAOYSA-N 0.000 description 1
- 125000003047 N-acetyl group Chemical group 0.000 description 1
- CRJGESKKUOMBCT-VQTJNVASSA-N N-acetylsphinganine Chemical compound CCCCCCCCCCCCCCC[C@@H](O)[C@H](CO)NC(C)=O CRJGESKKUOMBCT-VQTJNVASSA-N 0.000 description 1
- CHJJGSNFBQVOTG-UHFFFAOYSA-N N-methyl-guanidine Natural products CNC(N)=N CHJJGSNFBQVOTG-UHFFFAOYSA-N 0.000 description 1
- CAHGCLMLTWQZNJ-UHFFFAOYSA-N Nerifoliol Natural products CC12CCC(O)C(C)(C)C1CCC1=C2CCC2(C)C(C(CCC=C(C)C)C)CCC21C CAHGCLMLTWQZNJ-UHFFFAOYSA-N 0.000 description 1
- 108091034117 Oligonucleotide Proteins 0.000 description 1
- MUBZPKHOEPUJKR-UHFFFAOYSA-N Oxalic acid Chemical compound OC(=O)C(O)=O MUBZPKHOEPUJKR-UHFFFAOYSA-N 0.000 description 1
- 235000021319 Palmitoleic acid Nutrition 0.000 description 1
- 239000005662 Paraffin oil Substances 0.000 description 1
- 240000002834 Paulownia tomentosa Species 0.000 description 1
- 241000208317 Petroselinum Species 0.000 description 1
- IMQLKJBTEOYOSI-UHFFFAOYSA-N Phytic acid Natural products OP(O)(=O)OC1C(OP(O)(O)=O)C(OP(O)(O)=O)C(OP(O)(O)=O)C(OP(O)(O)=O)C1OP(O)(O)=O IMQLKJBTEOYOSI-UHFFFAOYSA-N 0.000 description 1
- 235000012550 Pimpinella anisum Nutrition 0.000 description 1
- 240000004760 Pimpinella anisum Species 0.000 description 1
- 235000008331 Pinus X rigitaeda Nutrition 0.000 description 1
- 241000018646 Pinus brutia Species 0.000 description 1
- 235000011613 Pinus brutia Nutrition 0.000 description 1
- 239000004952 Polyamide Substances 0.000 description 1
- 229920002873 Polyethylenimine Polymers 0.000 description 1
- 239000004721 Polyphenylene oxide Substances 0.000 description 1
- 239000004372 Polyvinyl alcohol Substances 0.000 description 1
- ZLMJMSJWJFRBEC-UHFFFAOYSA-N Potassium Chemical compound [K] ZLMJMSJWJFRBEC-UHFFFAOYSA-N 0.000 description 1
- 239000004153 Potassium bromate Substances 0.000 description 1
- 241000210053 Potentilla elegans Species 0.000 description 1
- QOSMNYMQXIVWKY-UHFFFAOYSA-N Propyl levulinate Chemical compound CCCOC(=O)CCC(C)=O QOSMNYMQXIVWKY-UHFFFAOYSA-N 0.000 description 1
- KNAHARQHSZJURB-UHFFFAOYSA-N Propylthiouracile Chemical compound CCCC1=CC(=O)NC(=S)N1 KNAHARQHSZJURB-UHFFFAOYSA-N 0.000 description 1
- 235000006040 Prunus persica var persica Nutrition 0.000 description 1
- 235000009984 Pterocarpus indicus Nutrition 0.000 description 1
- 244000086363 Pterocarpus indicus Species 0.000 description 1
- VYGQUTWHTHXGQB-UHFFFAOYSA-N Retinol hexadecanoate Natural products CCCCCCCCCCCCCCCC(=O)OCC=C(C)C=CC=C(C)C=CC1=C(C)CCCC1(C)C VYGQUTWHTHXGQB-UHFFFAOYSA-N 0.000 description 1
- 240000004808 Saccharomyces cerevisiae Species 0.000 description 1
- 235000005794 Salvia japonica Nutrition 0.000 description 1
- 244000295490 Salvia japonica Species 0.000 description 1
- 240000000513 Santalum album Species 0.000 description 1
- 235000008632 Santalum album Nutrition 0.000 description 1
- 244000272264 Saussurea lappa Species 0.000 description 1
- 235000006784 Saussurea lappa Nutrition 0.000 description 1
- BUGBHKTXTAQXES-UHFFFAOYSA-N Selenium Chemical compound [Se] BUGBHKTXTAQXES-UHFFFAOYSA-N 0.000 description 1
- VYPSYNLAJGMNEJ-UHFFFAOYSA-N Silicium dioxide Chemical compound O=[Si]=O VYPSYNLAJGMNEJ-UHFFFAOYSA-N 0.000 description 1
- 241000221095 Simmondsia Species 0.000 description 1
- DBMJMQXJHONAFJ-UHFFFAOYSA-M Sodium laurylsulphate Chemical compound [Na+].CCCCCCCCCCCCOS([O-])(=O)=O DBMJMQXJHONAFJ-UHFFFAOYSA-M 0.000 description 1
- 102000013275 Somatomedins Human genes 0.000 description 1
- 229920002472 Starch Polymers 0.000 description 1
- 229930182558 Sterol Natural products 0.000 description 1
- PJANXHGTPQOBST-VAWYXSNFSA-N Stilbene Natural products C=1C=CC=CC=1/C=C/C1=CC=CC=C1 PJANXHGTPQOBST-VAWYXSNFSA-N 0.000 description 1
- CZMRCDWAGMRECN-UGDNZRGBSA-N Sucrose Chemical compound O[C@H]1[C@H](O)[C@@H](CO)O[C@@]1(CO)O[C@@H]1[C@H](O)[C@@H](O)[C@H](O)[C@@H](CO)O1 CZMRCDWAGMRECN-UGDNZRGBSA-N 0.000 description 1
- 229930006000 Sucrose Natural products 0.000 description 1
- 102000019197 Superoxide Dismutase Human genes 0.000 description 1
- 108010012715 Superoxide dismutase Proteins 0.000 description 1
- FEWJPZIEWOKRBE-UHFFFAOYSA-N Tartaric acid Natural products [H+].[H+].[O-]C(=O)C(O)C(O)C([O-])=O FEWJPZIEWOKRBE-UHFFFAOYSA-N 0.000 description 1
- 244000125380 Terminalia tomentosa Species 0.000 description 1
- 235000005212 Terminalia tomentosa Nutrition 0.000 description 1
- DHXVGJBLRPWPCS-UHFFFAOYSA-N Tetrahydropyran Chemical compound C1CCOCC1 DHXVGJBLRPWPCS-UHFFFAOYSA-N 0.000 description 1
- 102000002933 Thioredoxin Human genes 0.000 description 1
- 239000005844 Thymol Substances 0.000 description 1
- MSCCTZZBYHQMQJ-AZAGJHQNSA-N Tocopheryl nicotinate Chemical compound C([C@@](OC1=C(C)C=2C)(C)CCC[C@H](C)CCC[C@H](C)CCCC(C)C)CC1=C(C)C=2OC(=O)C1=CC=CN=C1 MSCCTZZBYHQMQJ-AZAGJHQNSA-N 0.000 description 1
- XSTXAVWGXDQKEL-UHFFFAOYSA-N Trichloroethylene Chemical compound ClC=C(Cl)Cl XSTXAVWGXDQKEL-UHFFFAOYSA-N 0.000 description 1
- GSEJCLTVZPLZKY-UHFFFAOYSA-N Triethanolamine Chemical compound OCCN(CCO)CCO GSEJCLTVZPLZKY-UHFFFAOYSA-N 0.000 description 1
- DOOTYTYQINUNNV-UHFFFAOYSA-N Triethyl citrate Chemical compound CCOC(=O)CC(O)(C(=O)OCC)CC(=O)OCC DOOTYTYQINUNNV-UHFFFAOYSA-N 0.000 description 1
- QIVBCDIJIAJPQS-UHFFFAOYSA-N Tryptophan Natural products C1=CC=C2C(CC(N)C(O)=O)=CNC2=C1 QIVBCDIJIAJPQS-UHFFFAOYSA-N 0.000 description 1
- 241000384110 Tylos Species 0.000 description 1
- HZYXFRGVBOPPNZ-UHFFFAOYSA-N UNPD88870 Natural products C1C=C2CC(O)CCC2(C)C2C1C1CCC(C(C)=CCC(CC)C(C)C)C1(C)CC2 HZYXFRGVBOPPNZ-UHFFFAOYSA-N 0.000 description 1
- 230000006750 UV protection Effects 0.000 description 1
- LEHOTFFKMJEONL-UHFFFAOYSA-N Uric Acid Chemical compound N1C(=O)NC(=O)C2=C1NC(=O)N2 LEHOTFFKMJEONL-UHFFFAOYSA-N 0.000 description 1
- TVWHNULVHGKJHS-UHFFFAOYSA-N Uric acid Natural products N1C(=O)NC(=O)C2NC(=O)NC21 TVWHNULVHGKJHS-UHFFFAOYSA-N 0.000 description 1
- 229930003268 Vitamin C Natural products 0.000 description 1
- 244000068697 Vitis rotundifolia Species 0.000 description 1
- 235000006359 Vitis rotundifolia var rotundifolia Nutrition 0.000 description 1
- IAEVWHUMVCQYTK-UHFFFAOYSA-N [Cl-].C(C=C)(=O)NOCCC[N+](C)(C)C Chemical compound [Cl-].C(C=C)(=O)NOCCC[N+](C)(C)C IAEVWHUMVCQYTK-UHFFFAOYSA-N 0.000 description 1
- MEWQFMZMPMAMTG-UHFFFAOYSA-N [O].CCCCCCCCCCCCCCC Chemical compound [O].CCCCCCCCCCCCCCC MEWQFMZMPMAMTG-UHFFFAOYSA-N 0.000 description 1
- PNNXBWWSFIVKQW-UHFFFAOYSA-N [O].CCCCCCCCCCCCCCCC Chemical compound [O].CCCCCCCCCCCCCCCC PNNXBWWSFIVKQW-UHFFFAOYSA-N 0.000 description 1
- FVXZXFWDTIMEMA-UHFFFAOYSA-N [O].CCCCCCCCCCCCCCCCC Chemical compound [O].CCCCCCCCCCCCCCCCC FVXZXFWDTIMEMA-UHFFFAOYSA-N 0.000 description 1
- CIGIRZIOSVQVKQ-UHFFFAOYSA-N [O].CCCCCCCCCCCCCCCCCC Chemical compound [O].CCCCCCCCCCCCCCCCCC CIGIRZIOSVQVKQ-UHFFFAOYSA-N 0.000 description 1
- LXLLRHLKPYGEJC-UHFFFAOYSA-N [O].O(CCCCC)C(CCCCCC)OCCCCCC Chemical compound [O].O(CCCCC)C(CCCCCC)OCCCCCC LXLLRHLKPYGEJC-UHFFFAOYSA-N 0.000 description 1
- 238000010521 absorption reaction Methods 0.000 description 1
- IKHGUXGNUITLKF-XPULMUKRSA-N acetaldehyde Chemical compound [14CH]([14CH3])=O IKHGUXGNUITLKF-XPULMUKRSA-N 0.000 description 1
- 229940022663 acetate Drugs 0.000 description 1
- RRUDCFGSUDOHDG-UHFFFAOYSA-N acetohydroxamic acid Chemical compound CC(O)=NO RRUDCFGSUDOHDG-UHFFFAOYSA-N 0.000 description 1
- 230000002378 acidificating effect Effects 0.000 description 1
- 150000007513 acids Chemical class 0.000 description 1
- 229920006322 acrylamide copolymer Polymers 0.000 description 1
- 235000010419 agar Nutrition 0.000 description 1
- 125000003158 alcohol group Chemical group 0.000 description 1
- 229940072056 alginate Drugs 0.000 description 1
- 235000010443 alginic acid Nutrition 0.000 description 1
- 229920000615 alginic acid Polymers 0.000 description 1
- 125000001931 aliphatic group Chemical group 0.000 description 1
- 150000001338 aliphatic hydrocarbons Chemical class 0.000 description 1
- 229910052784 alkaline earth metal Inorganic materials 0.000 description 1
- 150000001342 alkaline earth metals Chemical class 0.000 description 1
- 125000004183 alkoxy alkyl group Chemical group 0.000 description 1
- 125000002521 alkyl halide group Chemical group 0.000 description 1
- 230000029936 alkylation Effects 0.000 description 1
- 238000005804 alkylation reaction Methods 0.000 description 1
- OENHQHLEOONYIE-UKMVMLAPSA-N all-trans beta-carotene Natural products CC=1CCCC(C)(C)C=1/C=C/C(/C)=C/C=C/C(/C)=C/C=C/C=C(C)C=CC=C(C)C=CC1=C(C)CCCC1(C)C OENHQHLEOONYIE-UKMVMLAPSA-N 0.000 description 1
- CUXYLFPMQMFGPL-SUTYWZMXSA-N all-trans-octadeca-9,11,13-trienoic acid Chemical compound CCCC\C=C\C=C\C=C\CCCCCCCC(O)=O CUXYLFPMQMFGPL-SUTYWZMXSA-N 0.000 description 1
- 229930002945 all-trans-retinaldehyde Natural products 0.000 description 1
- 239000008168 almond oil Substances 0.000 description 1
- 229940061720 alpha hydroxy acid Drugs 0.000 description 1
- 150000001280 alpha hydroxy acids Chemical class 0.000 description 1
- RGZSQWQPBWRIAQ-LSDHHAIUSA-N alpha-Bisabolol Natural products CC(C)=CCC[C@@](C)(O)[C@@H]1CCC(C)=CC1 RGZSQWQPBWRIAQ-LSDHHAIUSA-N 0.000 description 1
- CRIGTVCBMUKRSL-UHFFFAOYSA-N alpha-Damascone Natural products CC=CC(=O)C1C(C)=CCCC1(C)C CRIGTVCBMUKRSL-UHFFFAOYSA-N 0.000 description 1
- 239000011795 alpha-carotene Substances 0.000 description 1
- 235000003903 alpha-carotene Nutrition 0.000 description 1
- ANVAOWXLWRTKGA-HLLMEWEMSA-N alpha-carotene Natural products C(=C\C=C\C=C(/C=C/C=C(\C=C\C=1C(C)(C)CCCC=1C)/C)\C)(\C=C\C=C(/C=C/[C@H]1C(C)=CCCC1(C)C)\C)/C ANVAOWXLWRTKGA-HLLMEWEMSA-N 0.000 description 1
- UZFLPKAIBPNNCA-BQYQJAHWSA-N alpha-ionone Chemical compound CC(=O)\C=C\C1C(C)=CCCC1(C)C UZFLPKAIBPNNCA-BQYQJAHWSA-N 0.000 description 1
- QUMXDOLUJCHOAY-UHFFFAOYSA-N alpha-methylbenzyl acetate Natural products CC(=O)OC(C)C1=CC=CC=C1 QUMXDOLUJCHOAY-UHFFFAOYSA-N 0.000 description 1
- 229910000147 aluminium phosphate Inorganic materials 0.000 description 1
- YPZUZOLGGMJZJO-LQKXBSAESA-N ambroxan Chemical compound CC([C@@H]1CC2)(C)CCC[C@]1(C)[C@@H]1[C@]2(C)OCC1 YPZUZOLGGMJZJO-LQKXBSAESA-N 0.000 description 1
- UBNYRXMKIIGMKK-UHFFFAOYSA-N amiloxate Chemical compound COC1=CC=C(C=CC(=O)OCCC(C)C)C=C1 UBNYRXMKIIGMKK-UHFFFAOYSA-N 0.000 description 1
- 125000003277 amino group Chemical group 0.000 description 1
- 235000019270 ammonium chloride Nutrition 0.000 description 1
- KAOMOVYHGLSFHQ-UTOQUPLUSA-N anacardic acid Chemical compound CCC\C=C/C\C=C/CCCCCCCC1=CC=CC(O)=C1C(O)=O KAOMOVYHGLSFHQ-UTOQUPLUSA-N 0.000 description 1
- 235000014398 anacardic acid Nutrition 0.000 description 1
- ADFWQBGTDJIESE-UHFFFAOYSA-N anacardic acid 15:0 Natural products CCCCCCCCCCCCCCCC1=CC=CC(O)=C1C(O)=O ADFWQBGTDJIESE-UHFFFAOYSA-N 0.000 description 1
- 229940011037 anethole Drugs 0.000 description 1
- ZRALSGWEFCBTJO-UHFFFAOYSA-N anhydrous guanidine Natural products NC(N)=N ZRALSGWEFCBTJO-UHFFFAOYSA-N 0.000 description 1
- RDOXTESZEPMUJZ-UHFFFAOYSA-N anisole Chemical compound COC1=CC=CC=C1 RDOXTESZEPMUJZ-UHFFFAOYSA-N 0.000 description 1
- MYYIAHXIVFADCU-QMMMGPOBSA-N anserine Chemical compound CN1C=NC=C1C[C@H](NC(=O)CC[NH3+])C([O-])=O MYYIAHXIVFADCU-QMMMGPOBSA-N 0.000 description 1
- 239000002518 antifoaming agent Substances 0.000 description 1
- 125000004429 atom Chemical group 0.000 description 1
- 229960001799 aurothioglucose Drugs 0.000 description 1
- 229960001716 benzalkonium Drugs 0.000 description 1
- 125000001797 benzyl group Chemical group [H]C1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])* 0.000 description 1
- MJVXAPPOFPTTCA-UHFFFAOYSA-N beta-Sistosterol Natural products CCC(CCC(C)C1CCC2C3CC=C4C(C)C(O)CCC4(C)C3CCC12C)C(C)C MJVXAPPOFPTTCA-UHFFFAOYSA-N 0.000 description 1
- 235000013734 beta-carotene Nutrition 0.000 description 1
- 239000011648 beta-carotene Substances 0.000 description 1
- TUPZEYHYWIEDIH-WAIFQNFQSA-N beta-carotene Natural products CC(=C/C=C/C=C(C)/C=C/C=C(C)/C=C/C1=C(C)CCCC1(C)C)C=CC=C(/C)C=CC2=CCCCC2(C)C TUPZEYHYWIEDIH-WAIFQNFQSA-N 0.000 description 1
- NJKOMDUNNDKEAI-UHFFFAOYSA-N beta-sitosterol Natural products CCC(CCC(C)C1CCC2(C)C3CC=C4CC(O)CCC4C3CCC12C)C(C)C NJKOMDUNNDKEAI-UHFFFAOYSA-N 0.000 description 1
- 229960002747 betacarotene Drugs 0.000 description 1
- 210000000941 bile Anatomy 0.000 description 1
- 239000003613 bile acid Substances 0.000 description 1
- QBUVFDKTZJNUPP-UHFFFAOYSA-N biliverdin-IXalpha Natural products N1C(=O)C(C)=C(C=C)C1=CC1=C(C)C(CCC(O)=O)=C(C=C2C(=C(C)C(C=C3C(=C(C=C)C(=O)N3)C)=N2)CCC(O)=O)N1 QBUVFDKTZJNUPP-UHFFFAOYSA-N 0.000 description 1
- 230000033228 biological regulation Effects 0.000 description 1
- 229940036350 bisabolol Drugs 0.000 description 1
- HHGZABIIYIWLGA-UHFFFAOYSA-N bisabolol Natural products CC1CCC(C(C)(O)CCC=C(C)C)CC1 HHGZABIIYIWLGA-UHFFFAOYSA-N 0.000 description 1
- FZJUFJKVIYFBSY-UHFFFAOYSA-N bourgeonal Chemical compound CC(C)(C)C1=CC=C(CCC=O)C=C1 FZJUFJKVIYFBSY-UHFFFAOYSA-N 0.000 description 1
- CDQSJQSWAWPGKG-UHFFFAOYSA-N butane-1,1-diol Chemical compound CCCC(O)O CDQSJQSWAWPGKG-UHFFFAOYSA-N 0.000 description 1
- SNCZNSNPXMPCGN-UHFFFAOYSA-N butanediamide Chemical compound NC(=O)CCC(N)=O SNCZNSNPXMPCGN-UHFFFAOYSA-N 0.000 description 1
- KDYFGRWQOYBRFD-NUQCWPJISA-N butanedioic acid Chemical compound O[14C](=O)CC[14C](O)=O KDYFGRWQOYBRFD-NUQCWPJISA-N 0.000 description 1
- ULBTUVJTXULMLP-UHFFFAOYSA-N butyl octadecanoate Chemical compound CCCCCCCCCCCCCCCCCC(=O)OCCCC ULBTUVJTXULMLP-UHFFFAOYSA-N 0.000 description 1
- 235000019282 butylated hydroxyanisole Nutrition 0.000 description 1
- 229940043253 butylated hydroxyanisole Drugs 0.000 description 1
- CZBZUDVBLSSABA-UHFFFAOYSA-N butylated hydroxyanisole Chemical compound COC1=CC=C(O)C(C(C)(C)C)=C1.COC1=CC=C(O)C=C1C(C)(C)C CZBZUDVBLSSABA-UHFFFAOYSA-N 0.000 description 1
- 235000010354 butylated hydroxytoluene Nutrition 0.000 description 1
- 229940095259 butylated hydroxytoluene Drugs 0.000 description 1
- 229910052791 calcium Inorganic materials 0.000 description 1
- SGNBVLSWZMBQTH-PODYLUTMSA-N campesterol Chemical compound C1C=C2C[C@@H](O)CC[C@]2(C)[C@@H]2[C@@H]1[C@@H]1CC[C@H]([C@H](C)CC[C@@H](C)C(C)C)[C@@]1(C)CC2 SGNBVLSWZMBQTH-PODYLUTMSA-N 0.000 description 1
- 235000000431 campesterol Nutrition 0.000 description 1
- 239000010238 camphora Substances 0.000 description 1
- 229940025250 camphora Drugs 0.000 description 1
- 239000004204 candelilla wax Substances 0.000 description 1
- 229940073532 candelilla wax Drugs 0.000 description 1
- 235000013868 candelilla wax Nutrition 0.000 description 1
- SHZIWNPUGXLXDT-UHFFFAOYSA-N caproic acid ethyl ester Natural products CCCCCC(=O)OCC SHZIWNPUGXLXDT-UHFFFAOYSA-N 0.000 description 1
- 150000001720 carbohydrates Chemical class 0.000 description 1
- 235000014633 carbohydrates Nutrition 0.000 description 1
- 125000004432 carbon atom Chemical group C* 0.000 description 1
- 239000001768 carboxy methyl cellulose Substances 0.000 description 1
- 235000010948 carboxy methyl cellulose Nutrition 0.000 description 1
- 150000007942 carboxylates Chemical class 0.000 description 1
- 239000008112 carboxymethyl-cellulose Substances 0.000 description 1
- 239000004203 carnauba wax Substances 0.000 description 1
- 150000001746 carotenes Chemical class 0.000 description 1
- 235000005473 carotenes Nutrition 0.000 description 1
- 230000015556 catabolic process Effects 0.000 description 1
- 229920006317 cationic polymer Polymers 0.000 description 1
- 229920003086 cellulose ether Polymers 0.000 description 1
- 229940106189 ceramide Drugs 0.000 description 1
- ZVEQCJWYRWKARO-UHFFFAOYSA-N ceramide Natural products CCCCCCCCCCCCCCC(O)C(=O)NC(CO)C(O)C=CCCC=C(C)CCCCCCCCC ZVEQCJWYRWKARO-UHFFFAOYSA-N 0.000 description 1
- 229940073669 ceteareth 20 Drugs 0.000 description 1
- 229940085262 cetyl dimethicone Drugs 0.000 description 1
- 239000010628 chamomile oil Substances 0.000 description 1
- 235000019480 chamomile oil Nutrition 0.000 description 1
- 230000008859 change Effects 0.000 description 1
- 239000002738 chelating agent Substances 0.000 description 1
- 239000003638 chemical reducing agent Substances 0.000 description 1
- 239000013626 chemical specie Substances 0.000 description 1
- YZIYKJHYYHPJIB-UUPCJSQJSA-N chlorhexidine gluconate Chemical compound OC[C@@H](O)[C@@H](O)[C@H](O)[C@@H](O)C(O)=O.OC[C@@H](O)[C@@H](O)[C@H](O)[C@@H](O)C(O)=O.C1=CC(Cl)=CC=C1NC(=N)NC(=N)NCCCCCCNC(=N)NC(=N)NC1=CC=C(Cl)C=C1 YZIYKJHYYHPJIB-UUPCJSQJSA-N 0.000 description 1
- 229940074393 chlorogenic acid Drugs 0.000 description 1
- 229960001480 chlorozotocin Drugs 0.000 description 1
- 235000012000 cholesterol Nutrition 0.000 description 1
- 229960001231 choline Drugs 0.000 description 1
- OEYIOHPDSNJKLS-UHFFFAOYSA-N choline Chemical compound C[N+](C)(C)CCO OEYIOHPDSNJKLS-UHFFFAOYSA-N 0.000 description 1
- GTZCVFVGUGFEME-IWQZZHSRSA-N cis-aconitic acid Chemical compound OC(=O)C\C(C(O)=O)=C\C(O)=O GTZCVFVGUGFEME-IWQZZHSRSA-N 0.000 description 1
- BJIOGJUNALELMI-ARJAWSKDSA-N cis-isoeugenol Chemical compound COC1=CC(\C=C/C)=CC=C1O BJIOGJUNALELMI-ARJAWSKDSA-N 0.000 description 1
- SECPZKHBENQXJG-UHFFFAOYSA-N cis-palmitoleic acid Natural products CCCCCCC=CCCCCCCCC(O)=O SECPZKHBENQXJG-UHFFFAOYSA-N 0.000 description 1
- 229940043350 citral Drugs 0.000 description 1
- 229930003633 citronellal Natural products 0.000 description 1
- 235000000983 citronellal Nutrition 0.000 description 1
- 239000011248 coating agent Substances 0.000 description 1
- 238000000576 coating method Methods 0.000 description 1
- 235000017471 coenzyme Q10 Nutrition 0.000 description 1
- ACTIUHUUMQJHFO-UPTCCGCDSA-N coenzyme Q10 Chemical compound COC1=C(OC)C(=O)C(C\C=C(/C)CC\C=C(/C)CC\C=C(/C)CC\C=C(/C)CC\C=C(/C)CC\C=C(/C)CC\C=C(/C)CC\C=C(/C)CC\C=C(/C)CCC=C(C)C)=C(C)C1=O ACTIUHUUMQJHFO-UPTCCGCDSA-N 0.000 description 1
- 239000000084 colloidal system Substances 0.000 description 1
- 239000012141 concentrate Substances 0.000 description 1
- 238000009833 condensation Methods 0.000 description 1
- 230000005494 condensation Effects 0.000 description 1
- LAAPRQODJPXAHC-AATRIKPKSA-N coniferyl benzoate Chemical compound C1=C(O)C(OC)=CC(\C=C\COC(=O)C=2C=CC=CC=2)=C1 LAAPRQODJPXAHC-AATRIKPKSA-N 0.000 description 1
- 239000000470 constituent Substances 0.000 description 1
- 239000013078 crystal Substances 0.000 description 1
- 150000001924 cycloalkanes Chemical class 0.000 description 1
- HPXRVTGHNJAIIH-UHFFFAOYSA-N cyclohexanol Chemical compound OC1CCCCC1 HPXRVTGHNJAIIH-UHFFFAOYSA-N 0.000 description 1
- OOTFVKOQINZBBF-UHFFFAOYSA-N cystamine Chemical compound CCSSCCN OOTFVKOQINZBBF-UHFFFAOYSA-N 0.000 description 1
- 229940099500 cystamine Drugs 0.000 description 1
- UFULAYFCSOUIOV-UHFFFAOYSA-N cysteamine Chemical compound NCCS UFULAYFCSOUIOV-UHFFFAOYSA-N 0.000 description 1
- 235000018417 cysteine Nutrition 0.000 description 1
- XUJNEKJLAYXESH-UHFFFAOYSA-N cysteine Natural products SCC(N)C(O)=O XUJNEKJLAYXESH-UHFFFAOYSA-N 0.000 description 1
- 229960002433 cysteine Drugs 0.000 description 1
- 229960003067 cystine Drugs 0.000 description 1
- 125000002704 decyl group Chemical group [H]C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])* 0.000 description 1
- 238000006731 degradation reaction Methods 0.000 description 1
- 210000003298 dental enamel Anatomy 0.000 description 1
- 238000004332 deodorization Methods 0.000 description 1
- 230000035617 depilation Effects 0.000 description 1
- 125000005265 dialkylamine group Chemical group 0.000 description 1
- 150000001983 dialkylethers Chemical class 0.000 description 1
- 150000001991 dicarboxylic acids Chemical class 0.000 description 1
- OUWSNHWQZPEFEX-UHFFFAOYSA-N diethyl glutarate Chemical compound CCOC(=O)CCCC(=O)OCC OUWSNHWQZPEFEX-UHFFFAOYSA-N 0.000 description 1
- YSAVZVORKRDODB-WDSKDSINSA-N diethyl tartrate Chemical compound CCOC(=O)[C@@H](O)[C@H](O)C(=O)OCC YSAVZVORKRDODB-WDSKDSINSA-N 0.000 description 1
- 229960001673 diethyltoluamide Drugs 0.000 description 1
- 229940031768 diglycol stearate Drugs 0.000 description 1
- QBSJHOGDIUQWTH-UHFFFAOYSA-N dihydrolanosterol Natural products CC(C)CCCC(C)C1CCC2(C)C3=C(CCC12C)C4(C)CCC(C)(O)C(C)(C)C4CC3 QBSJHOGDIUQWTH-UHFFFAOYSA-N 0.000 description 1
- XSNQECSCDATQEL-UHFFFAOYSA-N dihydromyrcenol Chemical compound C=CC(C)CCCC(C)(C)O XSNQECSCDATQEL-UHFFFAOYSA-N 0.000 description 1
- 229930008394 dihydromyrcenol Natural products 0.000 description 1
- RXKJFZQQPQGTFL-UHFFFAOYSA-N dihydroxyacetone Chemical compound OCC(=O)CO RXKJFZQQPQGTFL-UHFFFAOYSA-N 0.000 description 1
- 239000000539 dimer Substances 0.000 description 1
- GQOKIYDTHHZSCJ-UHFFFAOYSA-M dimethyl-bis(prop-2-enyl)azanium;chloride Chemical compound [Cl-].C=CC[N+](C)(C)CC=C GQOKIYDTHHZSCJ-UHFFFAOYSA-M 0.000 description 1
- SWSQBOPZIKWTGO-UHFFFAOYSA-N dimethylaminoamidine Natural products CN(C)C(N)=N SWSQBOPZIKWTGO-UHFFFAOYSA-N 0.000 description 1
- 150000002009 diols Chemical class 0.000 description 1
- DMBHHRLKUKUOEG-UHFFFAOYSA-N diphenylamine Chemical compound C=1C=CC=CC=1NC1=CC=CC=C1 DMBHHRLKUKUOEG-UHFFFAOYSA-N 0.000 description 1
- KPUWHANPEXNPJT-UHFFFAOYSA-N disiloxane Chemical class [SiH3]O[SiH3] KPUWHANPEXNPJT-UHFFFAOYSA-N 0.000 description 1
- 229940085632 distearyl ether Drugs 0.000 description 1
- PWWSSIYVTQUJQQ-UHFFFAOYSA-N distearyl thiodipropionate Chemical compound CCCCCCCCCCCCCCCCCCOC(=O)CCSCCC(=O)OCCCCCCCCCCCCCCCCCC PWWSSIYVTQUJQQ-UHFFFAOYSA-N 0.000 description 1
- 235000019305 distearyl thiodipropionate Nutrition 0.000 description 1
- 238000009826 distribution Methods 0.000 description 1
- 229960000735 docosanol Drugs 0.000 description 1
- 235000013399 edible fruits Nutrition 0.000 description 1
- 229940108623 eicosenoic acid Drugs 0.000 description 1
- BITHHVVYSMSWAG-UHFFFAOYSA-N eicosenoic acid Natural products CCCCCCCCC=CCCCCCCCCCC(O)=O BITHHVVYSMSWAG-UHFFFAOYSA-N 0.000 description 1
- 239000003792 electrolyte Substances 0.000 description 1
- 239000004862 elemi Substances 0.000 description 1
- 238000004945 emulsification Methods 0.000 description 1
- 230000001804 emulsifying effect Effects 0.000 description 1
- 150000002085 enols Chemical class 0.000 description 1
- HCZKYJDFEPMADG-UHFFFAOYSA-N erythro-nordihydroguaiaretic acid Natural products C=1C=C(O)C(O)=CC=1CC(C)C(C)CC1=CC=C(O)C(O)=C1 HCZKYJDFEPMADG-UHFFFAOYSA-N 0.000 description 1
- XHEDLZYGAQSNTR-UHFFFAOYSA-N ethene;hexanedioic acid Chemical compound C=C.C=C.OC(=O)CCCCC(O)=O XHEDLZYGAQSNTR-UHFFFAOYSA-N 0.000 description 1
- BEFDCLMNVWHSGT-UHFFFAOYSA-N ethenylcyclopentane Chemical compound C=CC1CCCC1 BEFDCLMNVWHSGT-UHFFFAOYSA-N 0.000 description 1
- 125000001301 ethoxy group Chemical group [H]C([H])([H])C([H])([H])O* 0.000 description 1
- VQNUNMBDOKEZHS-UHFFFAOYSA-N ethoxymethoxycyclododecane Chemical compound CCOCOC1CCCCCCCCCCC1 VQNUNMBDOKEZHS-UHFFFAOYSA-N 0.000 description 1
- NTNZTEQNFHNYBC-UHFFFAOYSA-N ethyl 2-aminoacetate Chemical group CCOC(=O)CN NTNZTEQNFHNYBC-UHFFFAOYSA-N 0.000 description 1
- FKRCODPIKNYEAC-UHFFFAOYSA-N ethyl propionate Chemical compound CCOC(=O)CC FKRCODPIKNYEAC-UHFFFAOYSA-N 0.000 description 1
- DEFVIWRASFVYLL-UHFFFAOYSA-N ethylene glycol bis(2-aminoethyl)tetraacetic acid Chemical compound OC(=O)CN(CC(O)=O)CCOCCOCCN(CC(O)=O)CC(O)=O DEFVIWRASFVYLL-UHFFFAOYSA-N 0.000 description 1
- 238000001704 evaporation Methods 0.000 description 1
- 230000008020 evaporation Effects 0.000 description 1
- 230000003203 everyday effect Effects 0.000 description 1
- 239000004744 fabric Substances 0.000 description 1
- 229940043259 farnesol Drugs 0.000 description 1
- 229930002886 farnesol Natural products 0.000 description 1
- 239000003925 fat Substances 0.000 description 1
- 125000005313 fatty acid group Chemical group 0.000 description 1
- 150000002192 fatty aldehydes Chemical class 0.000 description 1
- 239000001148 ferula galbaniflua oil terpeneless Substances 0.000 description 1
- KSEBMYQBYZTDHS-HWKANZROSA-N ferulic acid Chemical compound COC1=CC(\C=C\C(O)=O)=CC=C1O KSEBMYQBYZTDHS-HWKANZROSA-N 0.000 description 1
- 235000001785 ferulic acid Nutrition 0.000 description 1
- 229940114124 ferulic acid Drugs 0.000 description 1
- KSEBMYQBYZTDHS-UHFFFAOYSA-N ferulic acid Natural products COC1=CC(C=CC(O)=O)=CC=C1O KSEBMYQBYZTDHS-UHFFFAOYSA-N 0.000 description 1
- QOLIPNRNLBQTAU-UHFFFAOYSA-N flavan Chemical compound C1CC2=CC=CC=C2OC1C1=CC=CC=C1 QOLIPNRNLBQTAU-UHFFFAOYSA-N 0.000 description 1
- 244000144992 flock Species 0.000 description 1
- 229960000304 folic acid Drugs 0.000 description 1
- 235000019152 folic acid Nutrition 0.000 description 1
- 239000011724 folic acid Substances 0.000 description 1
- 210000000245 forearm Anatomy 0.000 description 1
- 125000000524 functional group Chemical group 0.000 description 1
- 239000004864 galbanum Substances 0.000 description 1
- FOYKKGHVWRFIBD-UHFFFAOYSA-N gamma-tocopherol acetate Natural products CC(=O)OC1=C(C)C(C)=C2OC(CCCC(C)CCCC(C)CCCC(C)C)(C)CCC2=C1 FOYKKGHVWRFIBD-UHFFFAOYSA-N 0.000 description 1
- 239000007789 gas Substances 0.000 description 1
- WTEVQBCEXWBHNA-JXMROGBWSA-N geranial Chemical compound CC(C)=CCC\C(C)=C\C=O WTEVQBCEXWBHNA-JXMROGBWSA-N 0.000 description 1
- HIGQPQRQIQDZMP-UHFFFAOYSA-N geranil acetate Natural products CC(C)=CCCC(C)=CCOC(C)=O HIGQPQRQIQDZMP-UHFFFAOYSA-N 0.000 description 1
- HIGQPQRQIQDZMP-DHZHZOJOSA-N geranyl acetate Chemical compound CC(C)=CCC\C(C)=C\COC(C)=O HIGQPQRQIQDZMP-DHZHZOJOSA-N 0.000 description 1
- LBQIJVLKGVZRIW-ZDUSSCGKSA-N glabridin Chemical compound C1([C@H]2CC3=CC=C4OC(C=CC4=C3OC2)(C)C)=CC=C(O)C=C1O LBQIJVLKGVZRIW-ZDUSSCGKSA-N 0.000 description 1
- 229940093767 glabridin Drugs 0.000 description 1
- PMPYOYXFIHXBJI-ZDUSSCGKSA-N glabridin Natural products C1([C@H]2CC=3C=CC4=C(C=3OC2)CCC(O4)(C)C)=CC=C(O)C=C1O PMPYOYXFIHXBJI-ZDUSSCGKSA-N 0.000 description 1
- LBQIJVLKGVZRIW-UHFFFAOYSA-N glabridine Natural products C1OC2=C3C=CC(C)(C)OC3=CC=C2CC1C1=CC=C(O)C=C1O LBQIJVLKGVZRIW-UHFFFAOYSA-N 0.000 description 1
- 239000011521 glass Substances 0.000 description 1
- 150000008131 glucosides Chemical group 0.000 description 1
- 229930195712 glutamate Natural products 0.000 description 1
- 229940049906 glutamate Drugs 0.000 description 1
- 125000005908 glyceryl ester group Chemical group 0.000 description 1
- 229940074052 glyceryl isostearate Drugs 0.000 description 1
- 229940068939 glyceryl monolaurate Drugs 0.000 description 1
- 229940075507 glyceryl monostearate Drugs 0.000 description 1
- 229960002449 glycine Drugs 0.000 description 1
- 150000002333 glycines Chemical class 0.000 description 1
- 229960004275 glycolic acid Drugs 0.000 description 1
- 150000002337 glycosamines Chemical class 0.000 description 1
- 125000003147 glycosyl group Chemical group 0.000 description 1
- 239000003102 growth factor Substances 0.000 description 1
- 229960002350 guaiazulen Drugs 0.000 description 1
- 235000010417 guar gum Nutrition 0.000 description 1
- IUJAMGNYPWYUPM-UHFFFAOYSA-N hentriacontane Chemical compound CCCCCCCCCCCCCCCCCCCCCCCCCCCCCCC IUJAMGNYPWYUPM-UHFFFAOYSA-N 0.000 description 1
- NDJKXXJCMXVBJW-UHFFFAOYSA-N heptadecane Chemical compound CCCCCCCCCCCCCCCCC NDJKXXJCMXVBJW-UHFFFAOYSA-N 0.000 description 1
- 125000003187 heptyl group Chemical group [H]C([*])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])[H] 0.000 description 1
- 235000008216 herbs Nutrition 0.000 description 1
- JYTMDBGMUIAIQH-UHFFFAOYSA-N hexadecyl oleate Natural products CCCCCCCCCCCCCCCCOC(=O)CCCCCCCC=CCCCCCCCC JYTMDBGMUIAIQH-UHFFFAOYSA-N 0.000 description 1
- 125000004051 hexyl group Chemical group [H]C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])* 0.000 description 1
- HNDVDQJCIGZPNO-UHFFFAOYSA-N histidine Natural products OC(=O)C(N)CC1=CN=CN1 HNDVDQJCIGZPNO-UHFFFAOYSA-N 0.000 description 1
- 239000004021 humic acid Substances 0.000 description 1
- 238000005984 hydrogenation reaction Methods 0.000 description 1
- 230000003301 hydrolyzing effect Effects 0.000 description 1
- 125000002768 hydroxyalkyl group Chemical group 0.000 description 1
- WPFVBOQKRVRMJB-UHFFFAOYSA-N hydroxycitronellal Chemical compound O=CCC(C)CCCC(C)(C)O WPFVBOQKRVRMJB-UHFFFAOYSA-N 0.000 description 1
- BTFJIXJJCSYFAL-UHFFFAOYSA-N icosan-1-ol Chemical compound CCCCCCCCCCCCCCCCCCCCO BTFJIXJJCSYFAL-UHFFFAOYSA-N 0.000 description 1
- 238000011065 in-situ storage Methods 0.000 description 1
- PZOUSPYUWWUPPK-UHFFFAOYSA-N indole Natural products CC1=CC=CC2=C1C=CN2 PZOUSPYUWWUPPK-UHFFFAOYSA-N 0.000 description 1
- RKJUIXBNRJVNHR-UHFFFAOYSA-N indolenine Natural products C1=CC=C2CC=NC2=C1 RKJUIXBNRJVNHR-UHFFFAOYSA-N 0.000 description 1
- 230000005764 inhibitory process Effects 0.000 description 1
- 238000002347 injection Methods 0.000 description 1
- 239000007924 injection Substances 0.000 description 1
- 238000007689 inspection Methods 0.000 description 1
- 229920000831 ionic polymer Polymers 0.000 description 1
- 125000000959 isobutyl group Chemical group [H]C([H])([H])C([H])(C([H])([H])[H])C([H])([H])* 0.000 description 1
- KQNPFQTWMSNSAP-UHFFFAOYSA-N isobutyric acid Chemical compound CC(C)C(O)=O KQNPFQTWMSNSAP-UHFFFAOYSA-N 0.000 description 1
- 125000001972 isopentyl group Chemical group [H]C([H])([H])C([H])(C([H])([H])[H])C([H])([H])C([H])([H])* 0.000 description 1
- 125000000555 isopropenyl group Chemical group [H]\C([H])=C(\*)C([H])([H])[H] 0.000 description 1
- 239000001851 juniperus communis l. berry oil Substances 0.000 description 1
- CXORMDKZEUMQHX-UHFFFAOYSA-N kermesic acid Chemical compound O=C1C2=C(O)C(O)=CC(O)=C2C(=O)C2=C1C=C(O)C(C(O)=O)=C2C CXORMDKZEUMQHX-UHFFFAOYSA-N 0.000 description 1
- 238000004898 kneading Methods 0.000 description 1
- CSSYQJWUGATIHM-IKGCZBKSSA-N l-phenylalanyl-l-lysyl-l-cysteinyl-l-arginyl-l-arginyl-l-tryptophyl-l-glutaminyl-l-tryptophyl-l-arginyl-l-methionyl-l-lysyl-l-lysyl-l-leucylglycyl-l-alanyl-l-prolyl-l-seryl-l-isoleucyl-l-threonyl-l-cysteinyl-l-valyl-l-arginyl-l-arginyl-l-alanyl-l-phenylal Chemical compound C([C@H](N)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CS)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CC=1C2=CC=CC=C2NC=1)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CC=1C2=CC=CC=C2NC=1)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CCSC)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CC(C)C)C(=O)NCC(=O)N[C@@H](C)C(=O)N1CCC[C@H]1C(=O)N[C@@H](CO)C(=O)N[C@@H]([C@@H](C)CC)C(=O)N[C@@H]([C@@H](C)O)C(=O)N[C@@H](CS)C(=O)N[C@@H](C(C)C)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](C)C(=O)N[C@@H](CC=1C=CC=CC=1)C(O)=O)C1=CC=CC=C1 CSSYQJWUGATIHM-IKGCZBKSSA-N 0.000 description 1
- 229940078795 lactoferrin Drugs 0.000 description 1
- 235000021242 lactoferrin Nutrition 0.000 description 1
- 229940058690 lanosterol Drugs 0.000 description 1
- CAHGCLMLTWQZNJ-RGEKOYMOSA-N lanosterol Chemical compound C([C@]12C)C[C@@H](O)C(C)(C)[C@H]1CCC1=C2CC[C@]2(C)[C@H]([C@H](CCC=C(C)C)C)CC[C@@]21C CAHGCLMLTWQZNJ-RGEKOYMOSA-N 0.000 description 1
- 239000004816 latex Substances 0.000 description 1
- 229920000126 latex Polymers 0.000 description 1
- PYIDGJJWBIBVIA-UYTYNIKBSA-N lauryl glucoside Chemical compound CCCCCCCCCCCCO[C@@H]1O[C@H](CO)[C@@H](O)[C@H](O)[C@H]1O PYIDGJJWBIBVIA-UYTYNIKBSA-N 0.000 description 1
- 229940048848 lauryl glucoside Drugs 0.000 description 1
- 235000018219 lavender Nutrition 0.000 description 1
- 239000004611 light stabiliser Substances 0.000 description 1
- UWKAYLJWKGQEPM-UHFFFAOYSA-N linalool acetate Natural products CC(C)=CCCC(C)(C=C)OC(C)=O UWKAYLJWKGQEPM-UHFFFAOYSA-N 0.000 description 1
- KQQKGWQCNNTQJW-UHFFFAOYSA-N linolenic acid Natural products CC=CCCC=CCC=CCCCCCCCC(O)=O KQQKGWQCNNTQJW-UHFFFAOYSA-N 0.000 description 1
- 125000005645 linoleyl group Chemical group 0.000 description 1
- 229910003002 lithium salt Inorganic materials 0.000 description 1
- 159000000002 lithium salts Chemical class 0.000 description 1
- 229960004999 lycopene Drugs 0.000 description 1
- 235000012661 lycopene Nutrition 0.000 description 1
- 239000001751 lycopene Substances 0.000 description 1
- OAIJSZIZWZSQBC-GYZMGTAESA-N lycopene Chemical compound CC(C)=CCC\C(C)=C\C=C\C(\C)=C\C=C\C(\C)=C\C=C\C=C(/C)\C=C\C=C(/C)\C=C\C=C(/C)CCC=C(C)C OAIJSZIZWZSQBC-GYZMGTAESA-N 0.000 description 1
- OVWYEQOVUDKZNU-UHFFFAOYSA-N m-tolualdehyde Chemical compound CC1=CC=CC(C=O)=C1 OVWYEQOVUDKZNU-UHFFFAOYSA-N 0.000 description 1
- DMRBHZWQMKSQGR-UHFFFAOYSA-L magnesium;tetradecanoate Chemical compound [Mg+2].CCCCCCCCCCCCCC([O-])=O.CCCCCCCCCCCCCC([O-])=O DMRBHZWQMKSQGR-UHFFFAOYSA-L 0.000 description 1
- 239000000594 mannitol Substances 0.000 description 1
- 235000010355 mannitol Nutrition 0.000 description 1
- 125000002960 margaryl group Chemical group [H]C([*])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])[H] 0.000 description 1
- 229960003951 masoprocol Drugs 0.000 description 1
- 239000001098 melissa officinalis l. leaf oil Substances 0.000 description 1
- 229940041616 menthol Drugs 0.000 description 1
- 229960003151 mercaptamine Drugs 0.000 description 1
- 125000001434 methanylylidene group Chemical group [H]C#[*] 0.000 description 1
- 125000000956 methoxy group Chemical group [H]C([H])([H])O* 0.000 description 1
- 229920000609 methyl cellulose Polymers 0.000 description 1
- KVWWIYGFBYDJQC-UHFFFAOYSA-N methyl dihydrojasmonate Chemical compound CCCCCC1C(CC(=O)OC)CCC1=O KVWWIYGFBYDJQC-UHFFFAOYSA-N 0.000 description 1
- 150000004702 methyl esters Chemical class 0.000 description 1
- 239000004292 methyl p-hydroxybenzoate Substances 0.000 description 1
- 235000010270 methyl p-hydroxybenzoate Nutrition 0.000 description 1
- XJRBAMWJDBPFIM-UHFFFAOYSA-N methyl vinyl ether Chemical compound COC=C XJRBAMWJDBPFIM-UHFFFAOYSA-N 0.000 description 1
- LAQFLZHBVPULPL-UHFFFAOYSA-N methyl(phenyl)silicon Chemical compound C[Si]C1=CC=CC=C1 LAQFLZHBVPULPL-UHFFFAOYSA-N 0.000 description 1
- SWGZAKPJNWCPRY-UHFFFAOYSA-N methyl-bis(trimethylsilyloxy)silicon Chemical compound C[Si](C)(C)O[Si](C)O[Si](C)(C)C SWGZAKPJNWCPRY-UHFFFAOYSA-N 0.000 description 1
- 239000001923 methylcellulose Substances 0.000 description 1
- 235000010981 methylcellulose Nutrition 0.000 description 1
- LXCFILQKKLGQFO-UHFFFAOYSA-N methylparaben Chemical compound COC(=O)C1=CC=C(O)C=C1 LXCFILQKKLGQFO-UHFFFAOYSA-N 0.000 description 1
- 229960002216 methylparaben Drugs 0.000 description 1
- 229950000081 metilsulfate Drugs 0.000 description 1
- 239000004200 microcrystalline wax Substances 0.000 description 1
- 230000004048 modification Effects 0.000 description 1
- 239000001788 mono and diglycerides of fatty acids Substances 0.000 description 1
- 239000000178 monomer Substances 0.000 description 1
- 239000012170 montan wax Substances 0.000 description 1
- 229940043348 myristyl alcohol Drugs 0.000 description 1
- 125000001421 myristyl group Chemical group [H]C([*])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])[H] 0.000 description 1
- DUWWHGPELOTTOE-UHFFFAOYSA-N n-(5-chloro-2,4-dimethoxyphenyl)-3-oxobutanamide Chemical compound COC1=CC(OC)=C(NC(=O)CC(C)=O)C=C1Cl DUWWHGPELOTTOE-UHFFFAOYSA-N 0.000 description 1
- IJDNQMDRQITEOD-UHFFFAOYSA-N n-butane Chemical compound CCCC IJDNQMDRQITEOD-UHFFFAOYSA-N 0.000 description 1
- KWUZCAVKPCRJPO-UHFFFAOYSA-N n-ethyl-4-(6-methyl-1,3-benzothiazol-2-yl)aniline Chemical compound C1=CC(NCC)=CC=C1C1=NC2=CC=C(C)C=C2S1 KWUZCAVKPCRJPO-UHFFFAOYSA-N 0.000 description 1
- GOQYKNQRPGWPLP-UHFFFAOYSA-N n-heptadecyl alcohol Natural products CCCCCCCCCCCCCCCCCO GOQYKNQRPGWPLP-UHFFFAOYSA-N 0.000 description 1
- OFBQJSOFQDEBGM-UHFFFAOYSA-N n-pentane Natural products CCCCC OFBQJSOFQDEBGM-UHFFFAOYSA-N 0.000 description 1
- 239000002071 nanotube Substances 0.000 description 1
- 125000001624 naphthyl group Chemical group 0.000 description 1
- 230000007935 neutral effect Effects 0.000 description 1
- VVGIYYKRAMHVLU-UHFFFAOYSA-N newbouldiamide Natural products CCCCCCCCCCCCCCCCCCCC(O)C(O)C(O)C(CO)NC(=O)CCCCCCCCCCCCCCCCC VVGIYYKRAMHVLU-UHFFFAOYSA-N 0.000 description 1
- 125000004433 nitrogen atom Chemical group N* 0.000 description 1
- 125000001400 nonyl group Chemical group [H]C([*])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])[H] 0.000 description 1
- 235000012149 noodles Nutrition 0.000 description 1
- HLERILKGMXJNBU-UHFFFAOYSA-N norvaline betaine Chemical compound CCCC(C([O-])=O)[N+](C)(C)C HLERILKGMXJNBU-UHFFFAOYSA-N 0.000 description 1
- 108020004707 nucleic acids Proteins 0.000 description 1
- 102000039446 nucleic acids Human genes 0.000 description 1
- 150000007523 nucleic acids Chemical class 0.000 description 1
- ORPJZHOKKGOIGN-KNRYUCGFSA-N octadecanoic acid (2R,3S,4R,5R)-2,3,4,5,6-pentahydroxyhexanal Chemical compound OC[C@@H](O)[C@@H](O)[C@H](O)[C@@H](O)C=O.CCCCCCCCCCCCCCCCCC(O)=O.CCCCCCCCCCCCCCCCCC(O)=O ORPJZHOKKGOIGN-KNRYUCGFSA-N 0.000 description 1
- WWZKQHOCKIZLMA-UHFFFAOYSA-M octanoate Chemical compound CCCCCCCC([O-])=O WWZKQHOCKIZLMA-UHFFFAOYSA-M 0.000 description 1
- WWZKQHOCKIZLMA-UHFFFAOYSA-N octanoic acid Chemical compound CCCCCCCC(O)=O WWZKQHOCKIZLMA-UHFFFAOYSA-N 0.000 description 1
- 125000002347 octyl group Chemical group [H]C([*])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])[H] 0.000 description 1
- JRZJOMJEPLMPRA-UHFFFAOYSA-N olefin Natural products CCCCCCCC=C JRZJOMJEPLMPRA-UHFFFAOYSA-N 0.000 description 1
- 125000001117 oleyl group Chemical group [H]C([*])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])/C([H])=C([H])\C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])[H] 0.000 description 1
- 229920001542 oligosaccharide Polymers 0.000 description 1
- 150000002482 oligosaccharides Chemical class 0.000 description 1
- 239000004006 olive oil Substances 0.000 description 1
- 235000008390 olive oil Nutrition 0.000 description 1
- 239000003605 opacifier Substances 0.000 description 1
- 239000011368 organic material Substances 0.000 description 1
- 229920001558 organosilicon polymer Polymers 0.000 description 1
- 239000007800 oxidant agent Substances 0.000 description 1
- 230000001590 oxidative effect Effects 0.000 description 1
- LBIYNOAMNIKVKF-FPLPWBNLSA-N palmitoleyl alcohol Chemical compound CCCCCC\C=C/CCCCCCCCO LBIYNOAMNIKVKF-FPLPWBNLSA-N 0.000 description 1
- LBIYNOAMNIKVKF-UHFFFAOYSA-N palmitoleyl alcohol Natural products CCCCCCC=CCCCCCCCCO LBIYNOAMNIKVKF-UHFFFAOYSA-N 0.000 description 1
- JYTMDBGMUIAIQH-ZPHPHTNESA-N palmityl oleate Chemical compound CCCCCCCCCCCCCCCCOC(=O)CCCCCCC\C=C/CCCCCCCC JYTMDBGMUIAIQH-ZPHPHTNESA-N 0.000 description 1
- RUVINXPYWBROJD-UHFFFAOYSA-N para-methoxyphenyl Natural products COC1=CC=C(C=CC)C=C1 RUVINXPYWBROJD-UHFFFAOYSA-N 0.000 description 1
- 125000002958 pentadecyl group Chemical group [H]C([*])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])[H] 0.000 description 1
- JYVLIDXNZAXMDK-UHFFFAOYSA-N pentan-2-ol Chemical compound CCCC(C)O JYVLIDXNZAXMDK-UHFFFAOYSA-N 0.000 description 1
- UWJJYHHHVWZFEP-UHFFFAOYSA-N pentane-1,1-diol Chemical compound CCCCC(O)O UWJJYHHHVWZFEP-UHFFFAOYSA-N 0.000 description 1
- WCVRQHFDJLLWFE-UHFFFAOYSA-N pentane-1,2-diol Chemical compound CCCC(O)CO WCVRQHFDJLLWFE-UHFFFAOYSA-N 0.000 description 1
- 125000001147 pentyl group Chemical group C(CCCC)* 0.000 description 1
- CNVZJPUDSLNTQU-SEYXRHQNSA-N petroselinic acid Chemical compound CCCCCCCCCCC\C=C/CCCCC(O)=O CNVZJPUDSLNTQU-SEYXRHQNSA-N 0.000 description 1
- NBIIXXVUZAFLBC-UHFFFAOYSA-K phosphate Chemical compound [O-]P([O-])([O-])=O NBIIXXVUZAFLBC-UHFFFAOYSA-K 0.000 description 1
- 150000003009 phosphonic acids Chemical class 0.000 description 1
- 238000006552 photochemical reaction Methods 0.000 description 1
- CGIHFIDULQUVJG-UHFFFAOYSA-N phytantriol Chemical compound CC(C)CCCC(C)CCCC(C)CCCC(C)(O)C(O)CO CGIHFIDULQUVJG-UHFFFAOYSA-N 0.000 description 1
- CGIHFIDULQUVJG-VNTMZGSJSA-N phytantriol Natural products CC(C)CCC[C@H](C)CCC[C@H](C)CCC[C@@](C)(O)[C@H](O)CO CGIHFIDULQUVJG-VNTMZGSJSA-N 0.000 description 1
- 229940068041 phytic acid Drugs 0.000 description 1
- 239000000467 phytic acid Substances 0.000 description 1
- 235000002949 phytic acid Nutrition 0.000 description 1
- 239000000049 pigment Substances 0.000 description 1
- 125000004482 piperidin-4-yl group Chemical group N1CCC(CC1)* 0.000 description 1
- 239000000419 plant extract Substances 0.000 description 1
- 229920003229 poly(methyl methacrylate) Polymers 0.000 description 1
- 229920000058 polyacrylate Polymers 0.000 description 1
- 229920001515 polyalkylene glycol Polymers 0.000 description 1
- 229920002647 polyamide Polymers 0.000 description 1
- 229920000728 polyester Polymers 0.000 description 1
- 229920000570 polyether Polymers 0.000 description 1
- 229920000223 polyglycerol Polymers 0.000 description 1
- 229920000151 polyglycol Polymers 0.000 description 1
- 239000010695 polyglycol Substances 0.000 description 1
- 238000006116 polymerization reaction Methods 0.000 description 1
- 239000004926 polymethyl methacrylate Substances 0.000 description 1
- 150000003077 polyols Chemical class 0.000 description 1
- 229920002451 polyvinyl alcohol Polymers 0.000 description 1
- 239000011591 potassium Substances 0.000 description 1
- 229940094037 potassium bromate Drugs 0.000 description 1
- 235000019396 potassium bromate Nutrition 0.000 description 1
- 238000001556 precipitation Methods 0.000 description 1
- 239000002243 precursor Substances 0.000 description 1
- 150000003138 primary alcohols Chemical class 0.000 description 1
- 239000011164 primary particle Substances 0.000 description 1
- 239000003380 propellant Substances 0.000 description 1
- 229960002662 propylthiouracil Drugs 0.000 description 1
- ROSDSFDQCJNGOL-UHFFFAOYSA-N protonated dimethyl amine Natural products CNC ROSDSFDQCJNGOL-UHFFFAOYSA-N 0.000 description 1
- 125000001453 quaternary ammonium group Chemical group 0.000 description 1
- 230000005855 radiation Effects 0.000 description 1
- 150000003254 radicals Chemical class 0.000 description 1
- 238000011084 recovery Methods 0.000 description 1
- NPCOQXAVBJJZBQ-UHFFFAOYSA-N reduced coenzyme Q9 Natural products COC1=C(O)C(C)=C(CC=C(C)CCC=C(C)CCC=C(C)CCC=C(C)CCC=C(C)CCC=C(C)CCC=C(C)CCC=C(C)CCC=C(C)C)C(O)=C1OC NPCOQXAVBJJZBQ-UHFFFAOYSA-N 0.000 description 1
- 230000009467 reduction Effects 0.000 description 1
- 230000002207 retinal effect Effects 0.000 description 1
- NCYCYZXNIZJOKI-OVSJKPMPSA-N retinal group Chemical group C\C(=C/C=O)\C=C\C=C(\C=C\C1=C(CCCC1(C)C)C)/C NCYCYZXNIZJOKI-OVSJKPMPSA-N 0.000 description 1
- 229940108325 retinyl palmitate Drugs 0.000 description 1
- 235000019172 retinyl palmitate Nutrition 0.000 description 1
- 239000011769 retinyl palmitate Substances 0.000 description 1
- 238000012552 review Methods 0.000 description 1
- 229930007790 rose oxide Natural products 0.000 description 1
- 239000000523 sample Substances 0.000 description 1
- 229940071089 sarcosinate Drugs 0.000 description 1
- DCKVNWZUADLDEH-UHFFFAOYSA-N sec-butyl acetate Chemical compound CCC(C)OC(C)=O DCKVNWZUADLDEH-UHFFFAOYSA-N 0.000 description 1
- 229910052711 selenium Inorganic materials 0.000 description 1
- 239000011669 selenium Substances 0.000 description 1
- 239000002453 shampoo Substances 0.000 description 1
- 239000000741 silica gel Substances 0.000 description 1
- 229910002027 silica gel Inorganic materials 0.000 description 1
- 150000004760 silicates Chemical class 0.000 description 1
- KZJWDPNRJALLNS-VJSFXXLFSA-N sitosterol Chemical compound C1C=C2C[C@@H](O)CC[C@]2(C)[C@@H]2[C@@H]1[C@@H]1CC[C@H]([C@H](C)CC[C@@H](CC)C(C)C)[C@@]1(C)CC2 KZJWDPNRJALLNS-VJSFXXLFSA-N 0.000 description 1
- 229950005143 sitosterol Drugs 0.000 description 1
- 235000015500 sitosterol Nutrition 0.000 description 1
- NLQLSVXGSXCXFE-UHFFFAOYSA-N sitosterol Natural products CC=C(/CCC(C)C1CC2C3=CCC4C(C)C(O)CCC4(C)C3CCC2(C)C1)C(C)C NLQLSVXGSXCXFE-UHFFFAOYSA-N 0.000 description 1
- XUXNAKZDHHEHPC-UHFFFAOYSA-M sodium bromate Chemical compound [Na+].[O-]Br(=O)=O XUXNAKZDHHEHPC-UHFFFAOYSA-M 0.000 description 1
- 239000011780 sodium chloride Substances 0.000 description 1
- 229940073490 sodium glutamate Drugs 0.000 description 1
- 229940057950 sodium laureth sulfate Drugs 0.000 description 1
- 235000019333 sodium laurylsulphate Nutrition 0.000 description 1
- SXHLENDCVBIJFO-UHFFFAOYSA-M sodium;2-[2-(2-dodecoxyethoxy)ethoxy]ethyl sulfate Chemical compound [Na+].CCCCCCCCCCCCOCCOCCOCCOS([O-])(=O)=O SXHLENDCVBIJFO-UHFFFAOYSA-M 0.000 description 1
- 235000010199 sorbic acid Nutrition 0.000 description 1
- 239000004334 sorbic acid Substances 0.000 description 1
- 229940075582 sorbic acid Drugs 0.000 description 1
- 239000008107 starch Substances 0.000 description 1
- 235000019698 starch Nutrition 0.000 description 1
- 125000004079 stearyl group Chemical group [H]C([*])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])[H] 0.000 description 1
- 150000003432 sterols Chemical group 0.000 description 1
- 235000003702 sterols Nutrition 0.000 description 1
- 229940032091 stigmasterol Drugs 0.000 description 1
- HCXVJBMSMIARIN-PHZDYDNGSA-N stigmasterol Chemical compound C1C=C2C[C@@H](O)CC[C@]2(C)[C@@H]2[C@@H]1[C@@H]1CC[C@H]([C@H](C)/C=C/[C@@H](CC)C(C)C)[C@@]1(C)CC2 HCXVJBMSMIARIN-PHZDYDNGSA-N 0.000 description 1
- 235000016831 stigmasterol Nutrition 0.000 description 1
- BFDNMXAIBMJLBB-UHFFFAOYSA-N stigmasterol Natural products CCC(C=CC(C)C1CCCC2C3CC=C4CC(O)CCC4(C)C3CCC12C)C(C)C BFDNMXAIBMJLBB-UHFFFAOYSA-N 0.000 description 1
- PJANXHGTPQOBST-UHFFFAOYSA-N stilbene Chemical compound C=1C=CC=CC=1C=CC1=CC=CC=C1 PJANXHGTPQOBST-UHFFFAOYSA-N 0.000 description 1
- 235000021286 stilbenes Nutrition 0.000 description 1
- KDYFGRWQOYBRFD-UHFFFAOYSA-L succinate(2-) Chemical compound [O-]C(=O)CCC([O-])=O KDYFGRWQOYBRFD-UHFFFAOYSA-L 0.000 description 1
- 239000001384 succinic acid Substances 0.000 description 1
- 239000005720 sucrose Substances 0.000 description 1
- 125000000020 sulfo group Chemical group O=S(=O)([*])O[H] 0.000 description 1
- 229940117986 sulfobetaine Drugs 0.000 description 1
- 125000001273 sulfonato group Chemical group [O-]S(*)(=O)=O 0.000 description 1
- 229910021653 sulphate ion Inorganic materials 0.000 description 1
- 210000000106 sweat gland Anatomy 0.000 description 1
- 230000008961 swelling Effects 0.000 description 1
- 239000011975 tartaric acid Substances 0.000 description 1
- 235000002906 tartaric acid Nutrition 0.000 description 1
- 229960003080 taurine Drugs 0.000 description 1
- 150000003505 terpenes Chemical class 0.000 description 1
- 235000007586 terpenes Nutrition 0.000 description 1
- 229920001897 terpolymer Polymers 0.000 description 1
- 125000004213 tert-butoxy group Chemical group [H]C([H])([H])C(O*)(C([H])([H])[H])C([H])([H])[H] 0.000 description 1
- IBYFOBGPNPINBU-UHFFFAOYSA-N tetradecenoic acid Natural products CCCCCCCCCCCC=CC(O)=O IBYFOBGPNPINBU-UHFFFAOYSA-N 0.000 description 1
- OULAJFUGPPVRBK-UHFFFAOYSA-N tetratriacontan-1-ol Chemical compound CCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCO OULAJFUGPPVRBK-UHFFFAOYSA-N 0.000 description 1
- 229960002663 thioctic acid Drugs 0.000 description 1
- NJRXVEJTAYWCQJ-UHFFFAOYSA-N thiomalic acid Chemical compound OC(=O)CC(S)C(O)=O NJRXVEJTAYWCQJ-UHFFFAOYSA-N 0.000 description 1
- 229940094937 thioredoxin Drugs 0.000 description 1
- 108060008226 thioredoxin Proteins 0.000 description 1
- 239000010678 thyme oil Substances 0.000 description 1
- 229960000790 thymol Drugs 0.000 description 1
- OGIDPMRJRNCKJF-UHFFFAOYSA-N titanium oxide Inorganic materials [Ti]=O OGIDPMRJRNCKJF-UHFFFAOYSA-N 0.000 description 1
- 229940042585 tocopherol acetate Drugs 0.000 description 1
- IBYFOBGPNPINBU-OUKQBFOZSA-N trans-2-tetradecenoic acid Chemical compound CCCCCCCCCCC\C=C\C(O)=O IBYFOBGPNPINBU-OUKQBFOZSA-N 0.000 description 1
- CRDAMVZIKSXKFV-UHFFFAOYSA-N trans-Farnesol Natural products CC(C)=CCCC(C)=CCCC(C)=CCO CRDAMVZIKSXKFV-UHFFFAOYSA-N 0.000 description 1
- BJIOGJUNALELMI-UHFFFAOYSA-N trans-isoeugenol Natural products COC1=CC(C=CC)=CC=C1O BJIOGJUNALELMI-UHFFFAOYSA-N 0.000 description 1
- QURCVMIEKCOAJU-UHFFFAOYSA-N trans-isoferulic acid Natural products COC1=CC=C(C=CC(O)=O)C=C1O QURCVMIEKCOAJU-UHFFFAOYSA-N 0.000 description 1
- ZCIHMQAPACOQHT-ZGMPDRQDSA-N trans-isorenieratene Natural products CC(=C/C=C/C=C(C)/C=C/C=C(C)/C=C/c1c(C)ccc(C)c1C)C=CC=C(/C)C=Cc2c(C)ccc(C)c2C ZCIHMQAPACOQHT-ZGMPDRQDSA-N 0.000 description 1
- LKOVPWSSZFDYPG-WUKNDPDISA-N trans-octadec-2-enoic acid Chemical compound CCCCCCCCCCCCCCC\C=C\C(O)=O LKOVPWSSZFDYPG-WUKNDPDISA-N 0.000 description 1
- RBNWAMSGVWEHFP-UHFFFAOYSA-N trans-p-Menthane-1,8-diol Chemical compound CC(C)(O)C1CCC(C)(O)CC1 RBNWAMSGVWEHFP-UHFFFAOYSA-N 0.000 description 1
- LOIYMIARKYCTBW-OWOJBTEDSA-N trans-urocanic acid Chemical compound OC(=O)\C=C\C1=CNC=N1 LOIYMIARKYCTBW-OWOJBTEDSA-N 0.000 description 1
- LOIYMIARKYCTBW-UHFFFAOYSA-N trans-urocanic acid Natural products OC(=O)C=CC1=CNC=N1 LOIYMIARKYCTBW-UHFFFAOYSA-N 0.000 description 1
- LADGBHLMCUINGV-UHFFFAOYSA-N tricaprin Chemical compound CCCCCCCCCC(=O)OCC(OC(=O)CCCCCCCCC)COC(=O)CCCCCCCCC LADGBHLMCUINGV-UHFFFAOYSA-N 0.000 description 1
- 229940093609 tricaprylin Drugs 0.000 description 1
- 229940087291 tridecyl alcohol Drugs 0.000 description 1
- 239000001069 triethyl citrate Substances 0.000 description 1
- VMYFZRTXGLUXMZ-UHFFFAOYSA-N triethyl citrate Natural products CCOC(=O)C(O)(C(=O)OCC)C(=O)OCC VMYFZRTXGLUXMZ-UHFFFAOYSA-N 0.000 description 1
- 235000013769 triethyl citrate Nutrition 0.000 description 1
- UFTFJSFQGQCHQW-UHFFFAOYSA-N triformin Chemical compound O=COCC(OC=O)COC=O UFTFJSFQGQCHQW-UHFFFAOYSA-N 0.000 description 1
- 238000005829 trimerization reaction Methods 0.000 description 1
- QXJQHYBHAIHNGG-UHFFFAOYSA-N trimethylolethane Chemical compound OCC(C)(CO)CO QXJQHYBHAIHNGG-UHFFFAOYSA-N 0.000 description 1
- 125000000026 trimethylsilyl group Chemical group [H]C([H])([H])[Si]([*])(C([H])([H])[H])C([H])([H])[H] 0.000 description 1
- VLPFTAMPNXLGLX-UHFFFAOYSA-N trioctanoin Chemical compound CCCCCCCC(=O)OCC(OC(=O)CCCCCCC)COC(=O)CCCCCCC VLPFTAMPNXLGLX-UHFFFAOYSA-N 0.000 description 1
- PHYFQTYBJUILEZ-IUPFWZBJSA-N triolein Chemical compound CCCCCCCC\C=C/CCCCCCCC(=O)OCC(OC(=O)CCCCCCC\C=C/CCCCCCCC)COC(=O)CCCCCCC\C=C/CCCCCCCC PHYFQTYBJUILEZ-IUPFWZBJSA-N 0.000 description 1
- OUYCCCASQSFEME-UHFFFAOYSA-N tyrosine Natural products OC(=O)C(N)CC1=CC=C(O)C=C1 OUYCCCASQSFEME-UHFFFAOYSA-N 0.000 description 1
- 229940035936 ubiquinone Drugs 0.000 description 1
- 125000002948 undecyl group Chemical group [H]C([*])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])[H] 0.000 description 1
- 229940116269 uric acid Drugs 0.000 description 1
- 229940099259 vaseline Drugs 0.000 description 1
- 235000015112 vegetable and seed oil Nutrition 0.000 description 1
- 239000008158 vegetable oil Substances 0.000 description 1
- WXETUDXXEZHSCS-MAVITOTKSA-N vertofix coeur Chemical compound C[C@@H]1CC[C@@]2(C(/CC3)=C\C(C)=O)[C@@H]3C(C)(C)[C@@H]1C2 WXETUDXXEZHSCS-MAVITOTKSA-N 0.000 description 1
- 239000010679 vetiver oil Substances 0.000 description 1
- 235000019154 vitamin C Nutrition 0.000 description 1
- 239000011718 vitamin C Substances 0.000 description 1
- 229920003169 water-soluble polymer Polymers 0.000 description 1
- 239000010497 wheat germ oil Substances 0.000 description 1
- OJYLAHXKWMRDGS-UHFFFAOYSA-N zingerone Chemical compound COC1=CC(CCC(C)=O)=CC=C1O OJYLAHXKWMRDGS-UHFFFAOYSA-N 0.000 description 1
- OENHQHLEOONYIE-JLTXGRSLSA-N β-Carotene Chemical compound CC=1CCCC(C)(C)C=1\C=C\C(\C)=C\C=C\C(\C)=C\C=C\C=C(/C)\C=C\C=C(/C)\C=C\C1=C(C)CCCC1(C)C OENHQHLEOONYIE-JLTXGRSLSA-N 0.000 description 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/33—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing oxygen
- A61K8/34—Alcohols
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q19/00—Preparations for care of the skin
- A61Q19/02—Preparations for care of the skin for chemically bleaching or whitening the skin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/33—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing oxygen
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/33—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing oxygen
- A61K8/34—Alcohols
- A61K8/347—Phenols
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A61P17/16—Emollients or protectives, e.g. against radiation
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Dermatology (AREA)
- Birds (AREA)
- Emergency Medicine (AREA)
- Epidemiology (AREA)
- Engineering & Computer Science (AREA)
- Organic Chemistry (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Chemical & Material Sciences (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Toxicology (AREA)
- Cosmetics (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Detergent Compositions (AREA)
Abstract
式(1)的羟基二苯基醚化合物作为黑素生成抑制剂和用于皮肤亮白的应用,其中R1、R2和R3各自独立地为氢、羟基、C1-C20烷基、羟基-取代的C1-C20烷基、C5-C7环烷基、C1-C20烷氧基、C1-C6烷基羰基、苯基、或苯基-C1-C3烷基;R4为氢、C1-C20烷基、羟基-取代的C1-C20烷基、C5-C7环烷基、羟基、甲酰基、丙酮基、烯丙基、羧基、羧基-C1-C3烷基、羧基烯丙基、C2-C20链烯基、C1-C6烷基羰基、C1-C3烷基羰基-C1-C3烷基、苯基、或苯基-C1-C3烷基;且R5为氢、C1-C20烷氧基、或C1-C6烷基羰基。
Description
本发明涉及卤代羟基二苯基醚化合物在皮肤处理,特别是皮肤亮白和作为黑素生成抑制剂中的应用。
对于在暴露于阳光后,不仅不改变皮肤颜色,且还可通过降低皮肤色素黑色素的生成或通过使其颜色亮白,赋予皮肤更亮白外观的制剂存在强烈的兴趣。特别是在亚洲国家,期望浅色的肤色,即皮肤亮白或防止晒成褐色。
因此,本发明的问题是发现能防止皮肤晒成褐色且同时亮白皮肤的组合物。
令人惊奇的是,现已发现某些卤代羟基二苯基醚化合物能解决该问题。
因此,本发明涉及(a)式(1)的卤代羟基二苯基醚化合物作为黑素生成抑制剂和用于皮肤亮白的应用
Y为氯或溴,
Z为SO2H、NO2、或C1-C4烷基;
m为0或1;
n为1或2;
r为0-3;
o为1-3;且
p为0、1或2。
C1-C20烷基为直链或支化烷基,例如甲基、乙基、正丙基、异丙基、正丁基、仲丁基、叔丁基、戊基、异戊基或叔戊基、己基、庚基、辛基、异辛基、壬基、癸基、十一烷基、十二烷基、十四烷基、十五烷基、十六烷基、十七烷基或十八烷基。
C1-C20烷氧基为直链或支化烷氧基,例如甲氧基、乙氧基、正丙氧基、异丙氧基、正丁氧基、仲丁氧基、叔丁氧基、戊氧基、异戊氧基或叔戊氧基、己氧基、庚氧基、辛氧基、异辛氧基、壬氧基、癸氧基、十一烷氧基、十二烷氧基、十四烷氧基、十五烷氧基、十六烷氧基、十七烷氧基或十八烷氧基。
C2-C18链烯基为,例如,烯丙基、甲代烯丙基、异丙烯基、2-丁烯基、3-丁烯基、异丁烯基、正戊-2,4-二烯基、3-甲基-丁-2-烯基、正辛-2-烯基、正十二-2-烯基、异十二烯基、正十二-2-烯基或正十八-4-烯基。
C1-C6烷基羰基为具有带1-6个碳原子的烷基的直链或支化羰基,例如乙酰基、丙酰基、丁酰基、异丁酰基、戊酰基、异戊酰基、新戊酰基(pivalolyl)等。
适宜的羟基-取代的C1-C20烷基为,例如,羟甲基、羟乙基、羟丙基、羟丁基、羟戊基、羟己基、羟庚基、羟辛基、羟壬基、羟癸基等。
优选使用式(1)的卤代羟基二苯基醚,其中
m为0或1;
n为1或2;
o为1-3;
p为0或1;且
r为1或2。
特别优选下式化合物
其中
m为0或1;
o为1-3;且
r为1或2。
优选,在式(2)中,
m为0;且
o和r与权利要求3所限定的相同。
特别优选式(2)的羟基二苯基醚,其中
o为1或2;且
r为1。
根据本发明,非常特别优选使用下式化合物
本发明使用的式(1)的卤代羟基二苯基醚化合物还可用于有机表面的同时抗微生物处理。
本发明使用的式(1)的羟基二苯基醚化合物表现出显著的抗微生物作用,特别是对于致病的革兰氏阳性和革兰氏阴性细菌以及对于皮肤菌群(skinflora)细菌,以及另外的对于酵母和霉菌。因此,它们特别适用于皮肤和粘膜以及外皮附属物(毛发)的消毒、除臭和一般及抗微生物处理,更特别是用于手和伤口的消毒。
因此,它们适宜作为抗微生物活性成分和防腐剂,用于个人护理制剂,例如洗发剂、沐浴添加剂、护发产品、液体和固体皂(基于合成表面活性剂和饱和和/或不饱和脂肪酸的盐)、洗剂和霜、除臭剂、其它水溶液或醇溶液,例如用于皮肤、湿清洗织物、油或粉末的清洗溶液。
除了组分(a)的卤代羟基二苯基醚化合物以外,根据本发明还可使用其它具有皮肤-亮白性能的物质(组分(b))。
作为组分(b),可使用,例如,下列物质或物质种类:
1.吡喃酮衍生物,对应于下式
R为氢(=曲酸、5-羟基-2-羟甲基-4H-吡喃-4-酮)、或式(2a)的基团及其衍生物,例如曲酸葡糖苷;
2.氢醌,包括苷形式,和苷形式的氢醌衍生物,例如4-羟苯基-D-吡喃葡糖苷(=α-、或β-熊果苷),对应于式
(α-熊果苷)、或(β-熊果苷)、4-甲氧基苯乙基甲基醚D-吡喃葡糖苷、1,5,9,13-四甲基-4,8,12-十四碳三烯(9CI)、5,9,13-十五碳三烯-2-醇、6,10,14-三甲基-(9CI)、1,5,9,13-四甲基十四烷基D-吡喃葡糖苷;
3.间苯二酚衍生物,例如光甘草定(1,3-苯二酚、4-[(3R)-3,4-二氢-8,8-二甲基-2H,8H-苯并[1,2-b:3,4-b′]二吡喃-3-基]-)或4-丁基间苯二酚(=rucinol)、2,4-二羟基二苯甲酮和异构的二苯甲酮;
4.甘氨酸、L-α-谷氨酰基-L-半胱氨酰基-(=谷胱甘肽)、乙酰半胱氨酸、低聚肽;
5.烷基二羧酸,例如壬二酸(壬烷二羧酸)及其单-和二-酯;
6.1,2-二羟基苯基衍生物,例如4-(3,4-二羟基苯基)丁-2-醇、4-羟基-3-甲氧基苄基基丙酮(=姜酮)、4H-1-苯并吡喃-4-酮、2-(3,4-二羟基苯基)-3,5,7-三羟基-(=栎精),对应于下式
7.脲、(2,5-二氧代-4-咪唑烷基)-(=尿囊素),对应于下式
8.呋喃酮,例如3-羟基-4,5-二甲基-2(5H)-呋喃酮、3-羟基-4-甲基-5-乙基-2(5H)-呋喃酮;
9.苯乙醛;
10.苯甲醛,例如4-羟基苯甲醛和3-甲基苯甲醛;
11.4-甲氧基肉桂醛;
12.异构的癸烯酸(C10H18O2);
13.抗坏血酸和衍生物,例如6-酰基抗坏血酸2-葡糖苷;抗坏血酸的硫酸盐、硬脂酸盐或磷酸盐;
14.水杨酸衍生物,例如6-[(8Z)-8-十五碳烯基]-水杨酸;(漆树酸单烯)和6-[(8Z,11Z)-8,11,14-十五碳三烯基]-水杨酸(漆树酸三烯);
15.酚类物质,例如3-[8(Z)-十五碳烯基]酚或姜黄素酚类物质,例如姜黄素;
16.苯并[b]吡喃衍生物,例如[1]苯并吡喃[5,4,3-cde][1]苯并吡喃-5,10-二酮、2,3,7,8-四羟基-(7CI,8CI,9CI)(=鞣花酸);2′-羟基-2,4,4,7,4′-五甲基黄烷;2′-黄烷醇、2,4,4,4′,7-五甲基-,醋酸酯;2-(3,4-二氢-2,4,4,7-四甲基-2H-1-苯并吡喃-2-基)-5-甲基苯基和8-α-吡葡亚硝脲(glycopyranosyl)-7-羟基-5-甲基-2-(2-氧代丙基)-4H-1-苯并吡喃-4-酮(芦荟苦素),对应于下式
17.冰片基和肉桂酸酯衍生物,例如2-丙烯酸,3-(4-羟苯基)-,1,7,7-三甲基二环[2.2.1]庚-2-基酯,内-;2-丙烯酸,3-(4-甲氧基苯基)-,1,7,7-三甲基二环[2.2.1]庚-2-基酯,内-;2-丙烯酸,3-(4-羟苯基)-,1-甲基-3-(2,2,6-三甲基环己基)丙基酯;2-丙烯酸,3-苯基-,1-甲基-3-(2,2,6-三甲基环己基)丙基酯;2-丙烯酸,3-[4-(α-D-吡喃葡萄糖基氧基)苯基]-,(1R,2S,4R)-1,7,7-三甲基二环[2.2.1]庚-2-基酯;
18.薁及其衍生物,例如愈创薁(guajazulene)或岩兰薁、以及愈创醇;
19.细胞信使物质,例如细胞因子;前列腺素和肽生长因子;
20.α-羟基-羧酸,例如α-羟基丙酸(乳酸)以及柠檬酸和乌头酸;
适用于本发明用途的优选荧光增白剂对应于下式
其中
R3为M、未取代或取代的烷基或芳基;
R4为氢、未取代或取代的烷基或芳基;或-NR6R7,其中R6和R7各自独立地为氢、未取代或取代的烷基、或芳基,或R6和R7与连接它们的氮原子一起形成杂环基,特别是吗啉代或哌啶基;
R5为氢、未取代或取代的烷基或芳基、或式(1a)-(CH2)X2-O-SO3-M的基团;
R1和R2各自独立地为-OH、-Cl、-NH2、-O-C1-C4烷基、-O-芳基、-NH-C1-C4烷基、-N(C1-C4烷基)2、-N(C1-C4烷基)(羟基-C1-C4烷基)、-N(羟基-C1-C4烷基)2、-NH-芳基、吗啉代、或S-C1-C4烷基(芳基);
R8和R9各自独立地为氢、C1-C4烷基、苯基、或式的基团;
R10为氢、Cl、或SO3M;
R11为-CN、-SO3M、-N(C1-C4烷基)2、或N(芳基)2;
R12为氢、-SO3M、-O-C1-C4烷基、-CN、-Cl、-COO-C1-C4烷基、或CON(C1-C4烷基)2;
R13为氢、-C1-C4烷基、-Cl、或-SO3M;
R14和R15各自独立地为氢、C1-C4烷基、-SO3M、-Cl、或-O-C1-C4烷基;
R16为氢、或C1-C4烷基;
R17为氢、C1-C4烷基、-CN、-Cl、-COO-C1-C4烷基;-CON(C1-C4烷基)2、芳基、或-O-芳基;
M为氢、Na、K、Ca、Mg、铵;单-、二-、三-或四-C1-C4烷基铵;单-、二-或三-C1-C4羟烷基铵;或由C1-C4烷基和C1-C4羟烷基的混合物进行二-或三-取代的铵;
n1、n2和n3各自独立地为0、或1;
x1为1、或2;且
x2为1-3。
表示(未取代或)取代的烷基的R2、R3、R4、R5、R6和R7为C1-C12烷基,优选C1-C4烷基。这些烷基可为支化或非支化的和未取代或被卤素(例如氟、氯或溴)、C1-C4烷氧基(例如甲氧基或乙氧基)、苯基或羧基、C1-C4烷氧基羰基(例如乙酰基)、单-或二-C1-C4烷基氨基或被-SO3M取代的。
表示(未取代或)取代的芳基的R2、R3、R4、R5、R6和R7优选为苯基或萘基,其可为未取代的或被C1-C4烷基(例如甲基、乙基、丙基、异丙基、丁基、异丁基、仲丁基或叔丁基)、C1-C4烷氧基(例如甲氧基、乙氧基、丙氧基、异丙氧基、丁氧基、异丁氧基、仲丁氧基或叔丁氧基)、卤素(例如氟、氯或溴)、C2-C5烷酰基氨基(例如乙酰氨基、丙酰氨基或丁酰氨基)、硝基、磺基或被二-C1-C4烷基化氨基取代的。
优选以中性形式使用式(FW-01)的化合物,即优选M为碱金属(特别是钠)的阳离子、或胺。
在式(FW-01)的化合物中,优选R1为式的基团,其中R3如上所限定且优选为C1-C4烷基(特别是甲基或乙基);或式的基团,其中R4如上所限定且优选为C1-C4烷基(特别是甲基或乙基)、或-NR6R7(其中R6或R7如上所限定且优选为氢、C1-C4烷基(特别是甲基或乙基))、吗啉代或哌啶基,更特别是氢;或式的基团,其中R5如上所限定且优选为C1-C4烷基,特别是甲基或乙基取代的-SO3M,其中M如上所限定且优选为钠;且
通过举例,在下表1中列出有利地适用于本发明用途的荧光增白剂:
作为组分(b),优选使用曲酸、α-熊果苷、栎精、芦荟苦素、壬二酸、愈创醇、鞣花酸及其酯以及式(FW-22)的荧光增白剂。
在本发明的组合物中,可单独使用上述抑制剂中的每一种或相互混合使用。
还可使用多于一种的附加的皮肤-亮白化合物,例如两种、三种或四种组分(b)的其它化合物。
优选组分(a)∶(b)的比为1∶99,特别地5∶95,且更特别地10∶90至99∶1,优选95∶5,且特别地90∶10%重量的组分(b)。
特别优选其中比值(a)∶(b)为20∶80,优选30∶70,至80∶20,特别是70∶30的(a)和(b)的混合物。
尤其,可使用最后提到的组合物以改善溶解度或提高皮肤-亮白作用。
此外,本发明使用的组合物可包含一种或多种下列物质种类的UV-A或UV-B吸收剂作为组分(c):
表2.可附加地与本发明UV吸收剂使用的适宜的UV过滤物质 |
(在左栏中描述该UV吸收剂的一般范围;在右栏中指出具体化合物) |
对-氨基苯甲酸衍生物,例如4-二甲基氨基苯甲酸2-乙基己基酯; |
水杨酸衍生物,例如水杨酸2-乙基己基酯; |
二苯甲酮衍生物,例如2-羟基-4-甲氧基二苯甲酮及其5-磺酸衍生物; |
二苯基丙烯酸酯,例如2-乙基己基2-氰基-3,3-二苯基丙烯酸酯、和3-(苯并 呋喃基)2-氰基丙烯酸酯; |
3-咪唑-4-基丙烯酸和酯; |
苯并呋喃衍生物,特别是2-(对-氨基苯基)苯并呋喃衍生物,描述在 EP-A-582 189、US-A-5 338 539、US-A-5 518 713和EP-A-613 893中; |
聚合UV吸收剂,例如在EP-A-709 080中描述的丙二酸亚苄酯衍生物; |
肉桂酸衍生物,例如在US-A-5 601 811和WO97/00851中描述的4-甲氧 基肉桂酸2-乙基己基酯和异戊基酯或肉桂酸衍生物; |
樟脑衍生物,例如3-(4′-甲基)亚苄基-莰烷-2-酮、3-亚苄基莰烷-2-酮、 N-[2(和4)-2-氧基亚冰片-3-基-甲基)-苄基]丙烯酰胺聚合物、3-(4′-三甲基 铵)-亚苄基-莰烷-2-酮甲基硫酸酯、3,3′-(1,4-亚苯基二次甲基)-双(7,7-二甲 基-2-氧代-二环[2.2.1]庚烷-1-甲磺酸)及盐、3-(4′-磺基)亚苄基-莰烷-2-酮及 盐、樟脑苯甲烃铵甲硫酸盐; |
羟苯基三嗪化合物,例如2-(4′-甲氧苯基)-4,6-双(2′-羟基-4′-正辛氧基苯 基)-1,3,5-三嗪、2,4-双{[4-(3-(2-丙氧基)-2-羟基-丙氧基)-2-羟基]-苯 基}-6-(4-甲氧苯基)-1,3,5-三嗪、2,4-双{[4-(2-乙基-己氧基)-2-羟基]-苯 基}-6-[4-(2-甲氧基乙基-羧基)-苯氨基]-1,3,5-三嗪、2,4-双{[4-(三(三甲基甲 硅烷基氧基-甲硅烷基丙氧基)-2-羟基]-苯基}-6-(4-甲氧苯基)-1,3,5-三嗪、 2,4-双{[4-(2″-甲基丙烯氧基)-2-羟基]-苯基}-6-(4-甲氧苯基)-1,3,5-三嗪、 2,4-双{[4-(1′,1′,1′,3′,5′,5′,5′-七甲基三甲硅烷基-2″-甲基-丙氧基)-2-羟基]-苯 基}-6-(4-甲氧苯基)-1,3,5-三嗪、2,4-双{[4-(3-(2-丙氧基)-2-羟基-丙氧基)-2- 羟基]-苯基}-6-[4-乙基羧基)-苯氨基]-1,3,5-三嗪; |
物理遮光剂,涂覆或未涂覆,例如二氧化钛、氧化锌、氧化铁、云母、 MnO、Fe<sub>2</sub>O<sub>3</sub>、Ce<sub>2</sub>O<sub>3</sub>、Al<sub>2</sub>O<sub>3</sub>、ZrO<sub>2</sub>(表面涂层:聚甲基丙烯酸甲酯、甲基 硅油(methicone)(如CAS 9004-73-3所描述的甲基氢聚硅氧烷)、二甲基硅 油、异丙基钛三异硬脂酸酯(如CAS 61417-49-0所描述的)、金属皂例如硬 |
[0113]
表2.可附加地与本发明UV吸收剂使用的适宜的UV过滤物质 |
(在左栏中描述该UV吸收剂的一般范围;在右栏中指出具体化合物) |
脂酸镁(如CAS 4086-70-8所描述的)、全氟醇磷酸酯例如C<sub>9</sub>-C<sub>15</sub>氟醇磷酸 酯(如CAS 74499-44-8、JP5-86984、JP4-330007所描述的))。初级粒径平 均为15nm-35nm且粒径分布为100nm-300nm。 |
在DE100 11 317、EP1 133 980和EP1 046 391中公开的氨基羟基-二苯甲 酮衍生物 |
如EP1 167 358所公开的苯基-苯并咪唑衍生物 |
在″Sunscreens″,Eds.N.J.Lowe,N.A.Shaath,Marcel Dekker,Inc.,NewYork and Basel或在Cosmetics&Toiletries(107),50ff(1992)中描述的UV吸收剂也可用作附加的UV-防护物质。
特别优选下表3中所示的光-防护物质:
上述光-防护物质中的每一种(特别是如表3所述的优选的光-防护物质)可单独使用或相互混合使用,例如上表中所示的光-防护物质中的两种、三种、四种、五种或六种相互混合使用。
一些上表中所列的UV吸收剂可同时用作用于化妆品UV吸收剂的溶剂。
优选在本发明使用的组合物中作为组分(c)的为下式的三嗪UV吸收剂
其中
R1和R2各自独立地为C3-C18烷基、C2-C18链烯基、式-CH2-CH(-OH)-CH2-O-T1的基团;或
R1和R2为式的基团;
R12为直接键、直链或支化C1-C4亚烷基或式-Cm1H2m1-或-Cm1H2m1-O-的基团;
R13、R14和R15各自独立地为C1-C18烷基、C1-C18烷氧基或式的基团
R16为C1-C5烷基;
m1和m3各自独立地为1-4;
p1为0或1-5的数;
R3为氢、C1-C10烷基、-(CH2CHR5-O)n1-R4、或式-CH2-CH(-OH)-CH2-O-T1的基团;
R4为氢、M、C1-C5烷基、或式-(CH2)m2-O-T1的基团;
R5为氢、或甲基;
T1为氢、或C1-C8烷基;
Q1为C1-C18烷基;
M为金属阳离子;
m2为1-4;且
n1为1-16。
特别优选式
R6和R7各自独立地为C3-C18烷基、或-CH2-CH(-OH)-CH2-O-T1;
R8为C1-C10烷基或式
R9为氢、M、C1-C5烷基、或式-(CH2)m-O-T2的基团;
T1和T2各自独立地为氢、或C1-C5烷基;且
m为1-4。
主要感兴趣的是式(5a)和(5b)的化合物,其中
R6和R7各自独立地为C3-C18烷基、或-CH2-CH(-OH)-CH2-O-T1;
R8为C1-C10烷基;
以及式(5a)和(5b)的化合物,其中
R6和R7各自独立地为C3-C18烷基或-CH2-CH(-OH)-CH2-O-T1;且
T1为氢、或C1-C5烷基。
可提及的式(5)化合物的实例为:
2-(4′-甲氧苯基)-4,6-双(2′-羟基-4′-正辛氧苯基)-1,3,5-三嗪;
2,4-双{[4-(3-(2-丙氧基)-2-羟基-丙氧基)-2-羟基]-苯基}-6-(4-甲氧苯基)-1,3,5-三嗪;
2,4-双{[4-(2-乙基-己氧基)-2-羟基]-苯基}-6-[4-(2-甲氧基乙基-羧基)-苯氨基]-1,3,5-三嗪;
2,4-双{[4-(三(三甲基甲硅烷氧基-甲硅烷基丙氧基)-2-羟基]-苯基}-6-(4-甲氧苯基)-1,3,5-三嗪;
2,4-双{[4-(2″-甲基丙烯氧基)-2-羟基]-苯基}-6-(4-甲氧苯基)-1,3,5-三嗪;
2,4-双{[4-(1′,1′,1′,3′,5′,5′,5′-七甲基三甲硅烷基-2″-甲基-丙氧基)-2-羟基]-苯基}-6-(4-甲氧苯基)-1,3,5-三嗪;
2,4-双{[4-(3-(2-丙氧基)-2-羟基-丙氧基)-2-羟基]-苯基}-6-[4-乙基羧基)-苯氨基]-1,3,5-三嗪;和
2,4-双{[4-(2-乙基-己氧基)-2-羟基]-苯基}-6-(1-甲基吡咯-2-基)-1,3,5-三嗪。
非常特别优选其中R6和R7具有相同的含义的式(5)的那些三嗪化合物,且特别是下式化合物
根据本发明,还使用下式的苯并三唑化合物作为有机UV吸收剂
其中
T1为氢、或C1-C3烷基,且
T2为未取代的C1-C4烷基,优选叔丁基,或苯基-取代的C1-C4烷基,优选α,α-二甲基苄基。
本发明所用的优选的苯并三唑化合物对应于下式
其中
T2为氢、或C1-C12烷基,优选异辛基。
还优选下式的苯并三唑化合物
其中
T2为C1-C12烷基,优选异辛基。
进一步优选的与本发明所用的组分(c)相对应的化合物为甲氧基肉桂酸辛酯和二苯甲酮-3。
除了组分(a)、(b)和(c)以外,在本发明组合物中,还可使用抗氧化剂类型的第二光-防护物质作为组分(d),当UV辐射透过皮肤或毛发时,其中断触发的光化反应链。由于UV和光的作用可导致在配料中及皮肤上均形成有害自由基,因此,在化妆品光-防护中,该性能是期望的。通过给本发明组合物提供抗氧化剂,除了对UV损伤的防护以外,还同时实现了对配料中成分的光化降解的防护。这种抗氧化剂的典型的实例为:
-氨基酸(例如组氨酸、酪氨酸、色氨酸、苯基苯胺)及其衍生物,
-咪唑(例如尿刊酸)及其衍生物,
-肽,例如D,L-肌肽、D-肌肽、L-肌肽及其衍生物(例如鹅肌肽),
-类胡萝卜素、胡萝卜素(例如α-胡萝卜素、β-胡萝卜素、番茄红素)及其衍生物,
-绿原酸及其衍生物,
-硫辛酸及其衍生物(例如二氢硫辛酸),
-金硫葡萄糖(aurothioglycose)、丙基硫尿嘧啶及其它硫醇(例如硫氧还蛋白、谷胱甘肽、半胱氨酸、胱氨酸、胱胺和糖基、N-乙酰基、甲基、乙基、丙基、戊基、丁基和月桂基、棕榈酰、油烯基、α-亚油醇基(linoleyl)、胆甾醇基及其甘油基酯)及其盐,
-二月桂基硫代二丙酸酯、二硬脂基硫代二丙酸酯、硫代二丙酸及其衍生物(酯、醚、肽、脂质、核苷酸、核苷和盐)以及
-极小容许量的磺基肟化合物(例如S-(3-氨基-3-羧丙基)-S-丁基硫氧亚氨、高半胱氨酸磺基肟、S-(3-氨基-3-羧丙基)-S-丁基砜(butionine sulfone)、五-、六-、七-硫堇磺基肟),以及
-(金属)螯合剂(例如α-羟基脂肪酸、棕榈酸、植酸、乳铁蛋白)、α-羟酸(例如柠檬酸、乳酸、苹果酸)、腐殖酸、胆汁酸、胆汁提取物、胆红素、胆绿素、EDTA、EGTA及其衍生物、不饱和的脂肪酸及其衍生物(例如α-亚麻酸、亚油酸、油酸)、叶酸及其衍生物、泛醌和泛醇及其衍生物、生育酚及衍生物(例如维生素E醋酸盐)、维生素A及衍生物(例如维生素A棕榈酸酯)以及苯甲酸树脂的松柏基苯甲酸酯、芸香酸及其衍生物、α-糖基芸香苷、阿魏酸、亚糠基葡萄糖醇、肌肽、丁基羟基甲苯、丁基羟基茴香醚、去甲二氢愈创树脂酸(nordihydroguaiac resin acid)、去甲二氢愈创木酸、三羟基丁酰苯、尿酸及其衍生物、甘露糖及其衍生物、超氧化物歧化酶、锌及其衍生物(例如ZnO、ZnSO4)、硒及其衍生物(例如蛋氨酸硒)、茋及其衍生物(例如茋氧化物、反式-茋氧化物)和这些提及的活性成分的适用于本发明的衍生物(盐、酯、醚、糖、核苷酸、核苷、肽和脂质)。
还可提及的酚类抗氧化剂列于下表4中:
对于本发明组合物,还开始考虑使用位阻胺(也称为HALS化合物(=″受阻胺光稳定剂″))。
这种化合物优选为2,2,6,6-四烷基哌啶衍生物。
适用于本发明的四烷基哌啶衍生物的实例可在EP-A-356677,第3-17页,第a)-f)部分中找到。该EP-A的所述部分视为本说明书的一部分。使用下列四烷基哌啶衍生物是特别有利的:
双(2,2,6,6-四甲基-哌啶-4-基)癸二酸酯、双(2,2,6,6-四甲基-哌啶-4-基)丁二酸酯、双(1,2,2,6,6-五甲基哌啶-4-基)癸二酸酯、双(1-辛氧基-2,2,6,6-四甲基哌啶-4-基)癸二酸酯、正丁基-3,5-二-叔丁基-4-羟基苄基-丙二酸双(1,2,2,6,6-五甲基哌啶基)酯、1-羟乙基-2,2,6,6-四甲基-4-羟基哌啶和丁二酸的缩合产物、N,N′-双(2,2,6,6-四甲基-4-哌啶基)六亚甲基二胺和4-叔辛基氨基-2,6-二氯-1,3,5-s-三嗪的缩合产物、三(2,2,6,6-四甲基-4-哌啶基)次氮基三乙酸酯、四-(2,2,6,6-四甲基-4-哌啶基)-1,2,3,4-丁烷四酸酯(butanetetraoate)、1,1′-(1,2-乙烷二基)-双(3,3,5,5-四甲基-哌嗪酮)、4-苯甲酰-2,2,6,6-四甲基哌啶、4-硬脂酰氧基(stearyloxy)-2,2,6,6-四甲基哌啶、双(1,2,2,6,6-五甲基哌啶基)-2-正丁基-2-(2-羟基-3,5-二-叔丁基苄基)-丙二酸酯、3-正辛基-7,7,9,9-四甲基-1,3,8-三氮杂螺-[4.5]癸烷-2,4-二酮、双(1-辛氧基-2,2,6,6-四甲基哌啶基)癸二酸酯、双(1-辛氧基-2,2,6,6-四甲基哌啶基)丁二酸酯、N,N-双(2,2,6,6-四甲基-4-哌啶基)六亚甲基二胺和4-吗啉代-2,6-二氯-1,3,5-三嗪的缩合产物、2-氯-4,6-二-(4-正丁基氨基-2,2,6,6-四甲基哌啶基)-1,3,5-三嗪和1,2-双(3-氨丙基氨基)乙烷的缩合产物、2-氯-4,6-二-(4-正丁基氨基-1,2,2,6,6-五甲基哌啶基)-1,3,5-三嗪和1,2-双(3-氨丙基氨基)乙烷的缩合产物、8-乙酰基-3-十二烷基-7,7,9,9-四甲基-1,3,8-三氮杂螺[4.5]癸烷-2,4-二酮、3-十二烷基-1-(2,2,6,6-四甲基-4-哌啶基)-吡咯烷-2,5-二酮、3-十二烷基-1-(1,2,2,6,6-五甲基-4-哌啶基)-吡咯烷-2,5-二酮、4-十六烷氧基-和4-硬脂酰氧基-2,2,6,6-四甲基哌啶的混合物、2,6-二氯-1,3,5-三嗪、1,2-双(3-氨丙基氨基)乙烷和2,4,6-三氯-1,3,5-三嗪的缩合产物以及4-丁基氨基-2,2,6,6-四甲基-哌啶(CAS注册编号[136504-96-6]);(2,2,6,6-四甲基-4-哌啶基)-正十二烷基琥珀酰亚胺、(1,2,2,6,6-五甲基-4-哌啶基)-正十二烷基琥珀酰亚胺、2-十一烷基-7,7,9,9-四甲基-1-氧杂-3,8-二氮杂-4-代-螺[4,5]癸烷、7,7,9,9-四甲基-2-环十一烷基-1-氧杂-3,8-二氮杂-4-氧代螺[4,5]癸烷和表氯醇的反应产物、四(2,2,6,6-四甲基哌啶-4-基)丁烷-1,2,3,4-四羧酸酯、四(1,2,2,6,6-五甲基哌啶-4-基)丁烷-1,2,3,4-四羧酸酯、2,2,4,4-四甲基-7-氧杂-3,20-二氮杂-21-氧代-二螺[5.1.11.2]二十一烷、8-乙酰基-3-十二烷基-1,3,8-三氮杂-7,7,9,9-四甲基螺[4,5]癸烷-2,4-二酮、或下式化合物其中m为5-50的
或
抗氧化剂的比例通常为0.001-30重量%,优选0.01-3重量%,以本发明组合物的重量计。
组分(b)、(c)或(d)的附加物质可具有不同的功能:
a.对黑色素合成的直接影响,例如吡喃酮衍生物,特别是曲酸、4-羟苯基-D-吡喃葡糖苷(α-和β-熊果苷)、间苯二酚衍生物(例如间苯二酚)、苯并[b]吡喃衍生物(例如8-α-吡葡亚硝脲-7-羟基-5-甲基-2-(2-氧代丙基)-4H-1-苯并吡喃-4-酮(芦荟苦素)或鞣花酸)、薁、愈创醇和维生素C;
b.经由相互作用的细胞对黑色素合成的间接影响,例如维生素A、细胞因子、前列腺素或生长因子;
c.通过机械去除死皮的间接影响,例如水杨酸或乳酸盐,例如乳酸;
d.通过UV防护的间接影响:UV-A过滤器。
e.以荧光增白剂对皮肤亮白的直接影响:
通过L*值的偏移。
下表5给出了式(1)的羟基二苯基醚化合物(组分(a))与进一步的皮肤-亮白活性成分(组分(b))及UV吸收剂(组分(c))的混合物的实例。该数据涉及在最终化妆品配料中的重量%。
本发明所用的卤代羟基二苯基醚化合物及这些化合物与组分(b)和/或(c)的一种或多种代表物的混合物可用作化妆品配料。
因此,本发明还涉及一种化妆品配料,其包含:
(a)式(1)的化合物;和任选的
(b)进一步的皮肤-亮白活性成分,和任选的
(c)一种或多种UV-A和/或UV-B吸收剂,和任选的
(d)抗氧化剂,以及
化妆品可接受的辅助剂或载体。
优选,本发明的化妆品配料包含
0.001-10重量%,优选0.05-1重量%的组分(a),
0-10重量%,优选0.01-2重量%的组分(b),
0-30重量%,优选0.1-15重量%的组分(c),和
0-30重量%,优选0.01-5重量%的组分(d)。
本发明还涉及一种化妆品配料,其包含
0.05-2%的选自式(3)或(4)化合物的组分(a),
0.001-2%的选自式(FW 19)化合物的组分(b),
0.01-2%的选自式(AO 26)和(AO 27)化合物的组分(d)。
优选,这种配料用于含表面活性剂的清洗组合物中。
因此,本发明的另一方面为清洗组合物,其包含
0.05-2b.w.%的组分(a),
0.001-2b.w.%的组分(b),
0-2b.w.%的组分(c),
0-2b.w.%的组分(d),和
0.1-10b.w.%的一种或多种合成洗涤剂或皂或这种物质的组合。
如果期望,一种或多种组分(a)-(d)的化合物可存在于特定载体(例如纳米管(nanotope)、脂质体、玻璃颗粒、纳米胶体或乳液)中。
本发明的化妆品配料适用于保护对紫外线敏感的有机材料(特别是皮肤),并用于皮肤亮白。
本发明的组合物既可以溶解的形式也可以微粉形式使用。
可通过使用常规方法(例如通过将各组分在一起简单搅拌),将组分(a)、(b)及任选的(c)和(d)与辅助剂进行物理混合,制备化妆品组合物。例如,UV吸收剂可无需进一步处理地使用、或以微粉态使用或以粉末态使用。
化妆品组合物可为,例如,霜、凝胶、洗剂、醇和水/醇溶液、喷雾、混合脂质体、脂质体混合物、乳液、蜡/脂肪组合物、棒状制剂、粉末或软膏。
作为含水乳液和含油乳液(例如W/O、O/W、O/W/O和W/O/W乳液或微乳液),该组合物含有,例如,
0.1-30重量%,优选0.1-15重量%且特别是0.5-10重量%的组分(a)和任选的(b)、(c)和(d),以组合物总重计,
1-60重量%,特别是5-50重量%且优选10-35重量%的至少一种油组分,以组合物总重计,
0-30重量%,特别是1-30重量%且优选4-20重量%的至少一种乳化剂,以组合物总重计,
10-90重量%,特别是30-90重量%的水,以组合物总重计,和
0-88.9重量%,特别是1-50重量%的进一步的化妆品可接受的辅助剂。
作为含油组合物(例如油、W/O、O/W、O/W/O和W/O/W乳液或微乳液)的油组分,开始考虑使用,例如,基于具有6-18个碳原子,优选8-10个碳原子的脂肪醇的Guerbet醇、线性C6-C24脂肪酸与线性C3-C24醇的酯、支化C6-C13羧酸与线性C6-C24脂肪醇的酯、线性C6-C24脂肪酸与支化醇(特别是2-乙基己醇)的酯、羟基羧酸与线性或支化C6-C22脂肪醇的酯(特别是苹果酸二辛酯)、线性和/或支化脂肪酸与多元醇(例如丙二醇、二聚二醇或三聚三醇)和/或Guerbet醇的酯、基于C6-C10脂肪酸的甘油三脂、基于C6-C18脂肪酸的液态单-/二-/三-甘油脂混合物、C6-C24脂肪醇和/或Guerbet醇与芳族羧酸(特别是苯甲酸)的酯、C2-C12二羧酸与具有1-22个碳原子的线性或支化醇或具有2-10个碳原子和2-6羟基的多元醇的酯、植物油(例如向日葵油、橄榄油、豆油、菜籽油、杏仁油、西蒙得木油、橙油、麦胚油、桃仁油和椰子油的液体组分)、支化伯醇、取代的环己烷、线性和支化C6-C22脂肪醇碳酸酯、Guerbet碳酸酯、苯甲酸与线性和/或支化C6-C22醇(例如TN)的酯、具有总计12-36个碳原子,特别是12-24个碳原子的线性或支化、对称或不对称二烷基醚(例如二-正辛基醚、二-正癸基醚、二-正壬基醚、二-正十一烷基醚、二-正十二烷基醚、正己基-正辛基醚、正辛基-正癸基醚、正癸基-正十一烷基醚、正十一烷基-正-二烷基醚、正己基-正十一烷基醚、二-叔丁基醚、二异戊基醚、二-3-乙基癸基醚、叔丁基-正辛基醚、异戊基-正辛基醚和2-甲基-戊基-正辛基醚);环氧化脂肪酸酯与多元醇的开环产物、硅油和/或脂肪族烃或环烷烃。而且,其中重要的是脂肪酸与具有3-24个碳原子的醇的单酯。这类物质包括具有8-24个碳原子的脂肪酸(例如己酸、辛酸、2-乙基己酸、癸酸、月桂酸、异十三烷酸、肉豆蔻酸、棕榈酸、棕榈油酸、硬脂酸、异硬脂酸、油酸、反油酸、岩芹酸、亚油酸、亚麻酸、桐酸、花生酸、鳕油酸、山萮酸和芥酸及其工业混合物(technical mixture)(例如,在压力去除天然脂肪和油中获得、在来自于Roelen氧化合成的醛的还原中或在不饱和脂肪酸的二聚中获得))与醇(例如异丙醇、己醇(caproic alcohol)、辛醇、2-乙基己醇、癸醇(capric alcohol)、月桂醇、异十三烷醇、肉豆蔻醇、鲸蜡醇、棕榈油醇(palmoleyl alcohol)、硬脂醇、异硬脂醇、油醇、反油醇、岩芹醇(petroselinyl alcohol)、亚油醇(linoyl alcohol)、亚麻醇(linolenyl alcohol)、桐醇(elaeostearyl alcohol)、花生醇、二十碳烯醇、山萮醇、瓢儿菜醇和巴西烯醇(brassidyl alcohol)及其工业混合物(例如,在基于脂肪和油或来自于Roelen氧化合成的醛的工业甲基酯的高压氢化中以及作为单体部分在不饱和脂肪醇的二聚中获得))的酯化产物。其中特别重要的是肉豆蔻酸异丙酯、异壬酸C16-C18烷基酯、硬脂酸2-乙基己基酯、十六烷基油酸酯、三辛酸甘油酯、椰子脂肪醇正亮氨酸酯/辛酸酯和硬脂酸正丁酯。可使用的其它油组分为二羧酸酯(例如己二酸二-正丁基酯、己二酸二(2-乙基己基)酯、丁二酸二(2-乙基己基)酯和醋酸二异十三烷基酯)以及二醇酯(例如二油酸乙二醇酯、二异十三烷酸乙二醇酯、丙二醇二(2-乙基己酸酯)、二异硬脂酸丙二醇酯、二壬酸丙二醇酯、二异硬脂酸丁二醇酯和二辛酸新戊二醇酯)。
优选的一元醇或多元醇为乙醇、异丙醇、丙二醇、己二醇、甘油和山梨糖醇。还可使用一种或多种烷基羧酸的二-和/或三-价金属盐(碱土金属,尤其是Al3+)。
油组分的使用量可为,例如,1-60重量%,特别是5-50重量%且优选10-35重量%,以组合物的总重计。
任何常规可用的乳化剂可用于该组合物。
作为乳化剂,开始考虑使用,例如,选自下列的非离子表面活性剂:
-2-30摩尔环氧乙烷和/或0-5摩尔环氧丙烷与具有8-22个碳原子的线性脂肪醇、与具有12-22个碳原子的脂肪酸和在烷基中具有8-15个碳原子的烷基酚的加成产物,例如ceteareth-20或ceteareth-12;
-1-30摩尔环氧乙烷与具有3-6个碳原子的多元醇(特别是甘油)的加成产物的C12-C22脂肪酸单-酯和二-酯;
-具有6-22个碳原子的饱和及不饱和脂肪酸的甘油单-酯和二-酯及脱水山梨糖醇单-酯和二-酯及其环氧乙烷加成产物,例如硬脂酸甘油酯、异硬脂酸甘油酯、油酸甘油酯、油酸脱水山梨糖醇酯或脱水山梨糖醇倍半油酸酯;
-C8-C22烷基-单-和-低-糖苷及其乙氧基化类似物,优选低聚度为1.1-5,特别是1.2-1.4,且优选葡萄糖作为糖组分;
-2-60摩尔,特别是15-60摩尔环氧乙烷与蓖麻油和/或硬化蓖麻油的加成产物;
-多元醇酯且特别是聚甘油脂,例如二异硬脂酰聚甘油基-3二异硬脂酸酯、聚甘油基-3二异硬脂酸酯、二异硬脂酸三甘油酯、聚甘油基-2倍半异硬脂酸酯或聚甘油基二聚酯(polyglyceryl dimerate)。来自许多这些物质种类的化合物的混合物也是适宜的;
-基于线性、支化、不饱和或饱和C6-C22脂肪酸、蓖麻油酸以及12-羟基硬脂酸和甘油、聚甘油、季戊四醇、二季戊四醇、糖醇(例如山梨糖醇)、烷基葡糖苷(例如甲基葡糖苷、丁基葡糖苷、月桂基葡糖苷)以及多聚葡萄糖苷(例如纤维素)的偏酯,例如聚甘油基-2-二羟基硬脂酸酯或聚甘油基-2-二蓖麻醇酸酯;
-单-、二-和三-烷基磷酸盐以及单-、二-和/或三-PEG-烷基磷酸盐及其盐;
-羊毛蜡醇;
-一种或多种天然衍生物的乙氧基酯,例如氢化蓖麻油的聚乙氧基酯;
-硅油乳化剂,例如硅氧烷多元醇;
-聚硅氧烷/聚烷基/聚醚共聚物及相应的衍生物,例如十六烷基二甲基硅油共多元醇;
-季戊四醇、脂肪酸、柠檬酸和脂肪醇的混合酯(参见DE-A-1 165 574)和/或具有6-22个碳原子的脂肪酸、甲基葡萄糖和多元醇(优选甘油或聚甘油)的混合酯,例如聚甘油基-3葡萄糖二硬脂酸酯、聚甘油基-3葡萄糖二油酸酯、甲基葡萄糖二油酸酯或二椰子基赤癣醇基(dicocoyl pentaerythryl)二硬脂基柠檬酸酯,以及
-聚亚烷基二醇。
环氧乙烷和/或环氧丙烷与脂肪醇、脂肪酸、烷基酚、脂肪酸的甘油单-酯和二-酯以及脱水山梨糖醇单-酯和二-酯的加成产物,或环氧乙烷和/或环氧丙烷与蓖麻油的加成产物是已知的可市购的产品。它们通常为同系物的混合物,其烷氧基化的平均程度对应于环氧乙烷和/或环氧丙烷与基底的量的比,其中以该基底进行加成反应。环氧乙烷与甘油的加成产物的C12-C18脂肪酸单-酯和二-酯为已知的,例如,在DE-A-2 024 051中作为化妆品制剂用的脂肪-恢复物质。
现有技术中已知C8-C18烷基-单-和-低-糖苷、其制剂及其应用。特别是,其可通过将葡萄糖或低聚糖与具有8-18个碳原子的伯醇进行反应而制备。适宜的糖苷基团包括单糖苷(其中将环糖基配糖地(glycosidically)连接到脂肪醇上)以及低聚度优选高达约8的低聚糖苷。低聚度为基于常用于这种工业产物的同系物分布的统计平均值。
还可使用两性离子表面活性剂作为乳化剂。术语″两性离子表面活性剂″特别是指分子上带有至少一个季铵基团和至少一个羧酸酯和/或磺酸盐基团的表面-活性化合物。特别适宜的两性离子表面活性剂为所谓的甜菜碱,例如N-烷基-N,N-二甲基铵甘氨酸盐例如椰油烷基二甲基铵甘氨酸盐(cocoalkyldimethylammonium glycinate),N-酰氨基丙基-N,N-二甲基铵甘氨酸盐例如椰油酰氨基丙基二甲基铵甘氨酸盐,和在烷基或酰基上各具有8-18个碳原子的2-烷基-3-羧甲基-3-羟基乙基咪唑啉以及椰油酰氨基乙基羟乙基羧甲基甘氨酸酯。特别优选脂肪酸酰胺衍生物,其已知为CTFA名称椰油酰氨基丙基甜菜碱。两性表面活性剂同样适宜作为乳化剂。两性表面活性剂应理解为是指特别是这样的表面活性剂,其除含有C8-C18-烷基或-酰基以外,在分子中还含有至少一个游离氨基和至少一个-COOH或-SO3H基团且其能形成内盐。
适宜的两性表面活性剂的实例包括N-烷基甘氨酸、N-烷基丙酸、N-烷基氨基丁酸、N-烷基亚氨基二丙酸、N-羟乙基-N-烷基酰氨基丙基甘氨酸、N-烷基牛磺酸、N-烷基肌氨酸、2-烷基氨基丙酸和烷基氨基乙酸,其在烷基中均具有约8-18个碳原子。特别优选的两性表面活性剂为N-椰油烷基氨基丙酸酯、椰油酰氨基乙氨基丙酸酯和C12-C18酰基肌氨酸。除了两性乳化剂以外,还开始考虑使用季(quaternary)乳化剂,特别优选酯季(esterquat)型乳化剂,优选甲基-季铵化二-脂肪酸三乙醇胺酯盐。
优选非离子乳化剂。在所述非离子乳化剂中,特别优选具有8-22个碳原子和4-30个EO单元的乙氧基化脂肪醇。
乳化剂的用量可为,例如,1-30重量%,特别是4-20重量%且优选5-10重量%,以组合物的总重计。然而,原则上也可不使用乳化剂。
本发明组合物(例如霜、凝胶、洗剂、醇和水/醇溶液、乳液、蜡/脂肪组合物、棒状制剂(stick preparation)、粉末或软膏)还可含有缓和的(mild)表面活性剂、富脂剂、珠光蜡、稠度调节剂、增稠剂、聚合物、硅氧烷化合物、脂肪、蜡、稳定剂、生物活性成分、除臭活性成分、去屑剂、成膜剂、膨润剂、其它UV光-防护因子、抗氧化剂、水溶增溶剂、防腐剂、驱虫剂、增溶剂、芳香油、着色剂、细菌-抑制剂等作为进一步的辅助剂和添加剂。
适用于用作富脂剂的物质为,例如,羊毛脂和卵磷脂以及聚乙氧基化或丙烯酸酯化的羊毛脂和卵磷脂衍生物、多元醇脂肪酸酯、单酸甘油酯及脂肪酸链烷醇酰胺,后者同时起到泡沫稳定剂的作用。
适宜的缓和的表面活性剂的实例(即可非常好地与皮肤相容的表面活性剂)包括脂族醇聚乙二醇醚硫酸盐、甘油一酸酯硫酸盐、单-和/或二-烷基磺基丁二酸盐、脂肪酸异硫代硫酸盐、脂肪酸肌氨酸盐、脂肪酸牛磺酸盐、脂肪酸谷氨酸盐、α-烯烃磺酸盐、醚羧酸、烷基低聚葡糖苷、脂肪酸葡糖酰胺(glucamide)、烷基酰氨基甜菜碱和/或蛋白质脂肪酸缩合产物,后者优选基于小麦蛋白质。
对于珠光蜡,开始考虑使用,例如:亚烷基二醇酯,特别是双硬脂酸乙二醇酯;脂肪酸链烷醇酰胺,特别是椰子脂肪酸二乙醇酰胺;偏甘油酯,特别是硬脂酸甘油一酸酯;多价、未取代或羟基-取代的羧酸与具有6-22个碳原子的脂肪醇的酯,特别是酒石酸的长链酯;脂肪物质,例如脂肪醇、脂肪酮、脂肪醛、脂肪醚和脂肪碳酸酯,其总计具有至少24个碳原子,特别是月桂酮和二硬脂醚;脂肪酸,例如硬脂酸、羟基硬脂酸或山萮酸,具有12-22个碳原子的烯烃环氧化物与具有12-22个碳原子的脂肪醇和/或具有2-15个碳原子及2-10羟基的多元醇的开环产物,及其混合物。
对于稠度调节剂,特别是开始考虑使用具有12-22个碳原子且优选16-18个碳原子的脂肪醇或羟基脂肪醇,以及偏甘油酯、脂肪酸和羟基脂肪酸。优选具有相同链长度的烷基-低聚葡糖苷和/或脂肪酸N-甲基葡糖酰胺的这种物质和/或聚甘油聚-12-羟基硬脂酸酯的组合。适宜的增稠剂包括,例如,硅胶型(亲水硅酸)、多糖,特别是黄原胶、瓜尔胶-瓜尔胶、琼脂-琼脂、藻朊酸盐和甲基纤维素(Tyloses)、羧甲基纤维素和羟甲基纤维素,以及脂肪酸的高分子量的聚乙二醇单-和二-酯、聚丙烯酸酯(例如获自Goodrich的或获自Sigma的)、聚丙烯酰胺、聚乙烯醇和聚乙烯基吡咯烷酮、表面活性剂(例如乙氧基化脂肪酸甘油脂)、脂肪酸与多元醇(例如季戊四醇或三羟甲基丙烷)的酯、具有受限的同系物分布的脂肪醇乙氧基化物和烷基-低聚葡糖苷以及电解质(例如氯化钠或氯化铵)。
适宜的阳离子聚合物为,例如,阳离子纤维素衍生物,例如季铵化羟甲基纤维素(可由Amerchol获得,其名称为Polymer JR),阳离子淀粉,二烯丙基铵盐与丙烯酰胺的共聚物,季铵化的乙烯基吡硌烷酮/乙烯基咪唑聚合物,例如(BASF),聚乙二醇与胺的缩合产物,季铵化的(quarternised)胶原多肽,例如月桂基dimonium羟基丙基水解胶原(L/Grünau),季铵化小麦多肽,聚乙烯亚胺,阳离子有机硅聚合物,例如酰氨基甲基硅油(amidomethicone),己二酸和二甲基氨基羟基丙基二亚乙基三胺的共聚物(/Sandoz),丙烯酸与二甲基二烯丙基氯化铵的共聚物(550/Chemviron),聚氨基聚酰胺,如在例如FR-A-2252840中描述的,及其交联的水溶性聚合物,阳离子甲壳质衍生物,例如季铵化壳聚糖,任选地以微晶形式分布;二卤烷基(例如二溴丁烷)与双二烷基胺(例如双二甲基氨基-1,3-丙烷)的缩合产物,阳离子瓜尔胶,例如获自Celanese的C-17、C-16,季铵化的铵盐聚合物,例如获自Miranol的A-15、AD-1、AZ-1。
对于阴离子、两性离子、两性和非离子聚合物,开始考虑使用,例如,醋酸乙烯酯/巴豆酸共聚物、乙烯基吡硌烷酮/丙烯酸乙烯酯共聚物、醋酸乙烯酯/马来酸丁酯/丙烯酸异冰片基酯共聚物、甲基乙烯基醚/马来酸酐共聚物及其酯、未交联的聚丙烯酸和与多元醇交联的聚丙烯酸、丙烯酰氨基丙基三甲基氯化铵/丙烯酸酯共聚物、辛基丙烯酰胺/甲基丙烯酸甲酯/甲基丙烯酸叔丁基氨基乙基酯/甲基丙烯酸2-羟丙酯共聚物、聚乙烯基吡咯烷酮、乙烯基吡硌烷酮/醋酸乙烯酯共聚物、乙烯基吡硌烷酮/甲基丙烯酸二甲基氨基乙基酯/乙烯基己内酰胺三元共聚物以及任选的衍生的纤维素醚和硅氧烷。
适宜的硅氧烷化合物为,例如,二甲基聚硅氧烷、甲基苯基聚硅氧烷、环硅氧烷、以及氨基-、脂肪酸-、醇-、聚醚-、环氧-、氟-、糖苷-和/或烷基-改性的硅氧烷化合物,其在室温下可为液体形式或树脂状形式。二甲基硅油也是适宜的,其为平均链长度为200-300个二甲基硅氧烷单元的二甲基硅油与氢化硅酸盐的混合物。由Todd等对适宜的挥发性硅氧烷所进行的详细调查也可参见Cosm.Toil.91,27(1976)。
脂肪的典型实例为甘油脂,且对于蜡,尤其开始考虑使用在室温下为固体的蜂蜡、巴西棕榈蜡、小烛树腊、褐煤蜡、石蜡、氢化蓖麻油、和脂肪酸酯或微晶蜡,任选地与亲水性蜡(例如十六烷基硬脂醇或偏甘油酯)进行组合。脂肪酸的金属盐(例如镁、铝和/或锌的硬脂酸盐或蓖麻油酸盐)可用作稳定剂。
生物活性成分可理解为,例如,生育酚、醋酸生育酚酯、棕榈酸生育酚酯、抗坏血酸、脱氧核糖核酸、松香油、没药醇、尿囊素、植烷三醇、泛醇、AHA酸、氨基酸、神经酰胺、伪神经酰胺(pseudoceramide)、精油、植物提取物、核酸/碱、磷酸化碱和低聚核苷酸。
对于除臭活性成分,开始考虑使用,例如,止汗剂,例如铝的氯水合物,其为在空气中易于潮解且当通过蒸发进行浓缩时,形成氯化铝水溶液的无色吸湿晶体。铝的氯水合物用于生成止汗剂和除臭剂制剂,且据推测可通过由于蛋白质和/或多糖沉淀,部分关闭汗腺而起作用(参见J.Soc.Cosm.Chem.24,281(1973))。例如,对应于式Al2(OH)5Clx2.5H2O的铝的氯水合物(获自Hoechst AG,Frankfurt(FRG),商标为)是可市购的,特别优选使用该铝的氯水合物(参见J.Pharm.Pharmacol.26,531(1975))。除了该氯水合物(chlorohydrate)以外,还可使用羟基乙酸铝和酸性铝/锆盐。可添加酯酶抑制剂作为进一步的除臭活性成分。优选,这种抑制剂为柠檬酸三烷基酯,例如柠檬酸三甲酯、柠檬酸三丙酯、柠檬酸三异丙酯、柠檬酸三丁酯且特别是柠檬酸三乙酯(CAT,Henkel KGaA,Düsseldorf/FRG),其抑制酶活性并从而减少气味的形成。很可能,柠檬酸酯分裂释放出游离酸,该游离酸降低皮肤的pH值至抑制酶的程度。开始考虑作为酯酶抑制剂的其它物质为甾醇硫酸酯或磷酸酯,例如羊毛甾醇、胆甾醇、菜油甾醇、豆甾醇和谷甾醇硫酸酯或磷酸酯,二羧酸及其酯,例如戊二酸、戊二酸单乙酯、戊二酸二乙酯、己二酸、己二酸单乙酯、己二酸二乙酯、丙二酸和丙二酸二乙酯,和羟基羧酸及其酯,例如柠檬酸、苹果酸、酒石酸或酒石酸二乙酯。在制剂(特别是棒状制剂)中也可存在影响菌群(germ flora)并杀灭汗-分解细菌或抑制汗-分解细菌生长的抗菌活性成分。其实例包括壳聚糖、苯氧乙醇、洗必泰葡萄糖酸酯和4-(2-叔丁基-5-甲基苯氧基)-酚。
为了改善流动特性,还可使用水溶增溶剂,例如乙醇、异丙醇或多元醇。优选,开始考虑用于该目的的多元醇具有2-15个碳原子及至少两个羟基。多元醇还可含有其它官能团,特别是氨基和/或可以氮进行改性。典型实例为:
-甘油;
-亚烷基二醇,例如乙二醇、二甘醇、丙二醇、丁二醇、己二醇以及平均分子量为100-1000道尔顿的聚乙二醇;
-固有缩合度为1.5-10的工业低聚甘油混合物,例如双甘油含量为40-50重量%的工业双甘油混合物;
-羟甲基化合物,例如,特别是,三羟甲基乙烷、三羟甲基丙烷、三羟甲基丁烷、季戊四醇和二季戊四醇;
-低级烷基-葡糖苷,特别是烷基中带有1-8个碳原子的那些,例如甲基和丁基葡糖苷;
-具有5-12个碳原子的糖醇,例如山梨糖醇或甘露糖醇;
-具有5-12个碳原子的糖,例如葡萄糖或蔗糖;
-氨基糖,例如葡糖胺;
-二醇胺,例如二乙醇胺或2-氨基-1,3-丙二醇。
适宜的防腐剂包括,例如,苯氧乙醇、甲醛溶液、对羟基苯甲酸酯类、戊二醇或山梨酸以及Cosmetics Regulations的A和B部分的附录6中所列的其它物质种类。适宜的驱虫剂包括,例如,N,N-二乙基-间-甲苯酰胺、1,2-戊二醇和驱虫剂3535。
对于芳香油,可提及天然和/或合成芳族物质的混合物。天然芳族物质为,例如,来自花(百合、熏衣草、玫瑰、茉莉、橙花油、依兰)、茎和叶(天竺葵、广藿香、橙叶)、果实(茴香子、芫荽、葛缕子(caraway)、杜松)、果皮(香柠檬、柠檬、橙)、根(肉豆蔻、当归、芹菜、小豆蔻、木香(costus)、鸢尾、菖蒲)、木材(松木、檀香木、愈创木、杉木、蔷薇木)、药草和草(龙蒿、柠檬草、鼠尾草、百里香)、针叶和小枝(云杉、松树、欧洲赤松、山松)及树脂和香脂(古蓬香脂、榄香脂、安息香、没药、乳香、愈伤草树脂)的提取物。还开始考虑动物原料,例如麝猫香和海狸香。典型的合成芳族物质为,例如,酯、醚、醛、酮、醇或烃类的产物。酯类的芳族物质化合物为,例如,醋酸苄酯、异丁酸苯氧基乙基酯、醋酸对-叔丁基环己基酯、醋酸里哪酯、醋酸二甲基苄基甲基(carbinyl)酯、醋酸苯乙酯、苯甲酸里哪酯、甲酸苄酯、甘氨酸乙基甲基苯基酯、丙酸烯丙基环己基酯、丙酸苏合香酯(styrallyl propionate)和水杨酸苄酯。醚包括,例如,苄基乙基醚;醛包括,例如,具有8-18个烃原子的线性正构醛、柠檬醛、香茅醛、香茅基氧化乙醛、兔耳草醛、羟基香茅醛、铃兰醛以及bourgeonal;酮包括,例如,紫罗酮、α,β-异甲基紫罗酮和甲基雪松基(cedryl)酮;醇包括,例如,茴香脑、香茅醇、丁子香酚、异丁子香酚、香叶醇、里哪醇、苯乙醇和萜品醇;且烃主要包括萜烯和香脂。然而,优选使用不同芳族物质的混合物,这些物质在一起产生有吸引力的气味。主要用作香味组分的挥发性相对低的香精油还可适宜地作为芳香油,例如鼠尾草油、春黄菊油、丁香油、蜂花油、肉桂叶的油、椴树花油、杜松子油、香根草油、乳香油、古蓬香脂油、labolanum油和杂薰衣草油。优选使用香柠檬油、二氢月桂烯醇、铃兰醛、新铃兰醛、香茅醇、苯乙醇、香叶醇、苄基丙酮、兔耳草醛、里哪醇、boisambrene forte、ambroxan、吲哚、hedione、sandelice、柠檬油、红橘油、橙油、甘醇酸烯丙基戊基酯、cyclovertal、杂薰衣草油、肉豆蔻酒鼠尾草油、α-二氢大马酮、波旁老鹳草油、水杨酸环己酯、vertofix coeur、异-E-Super、Fixolide NP、evernyl、iraldein gamma、苯乙酸、乙酸香叶酯、醋酸苄酯、氧化玫瑰、romillat、irotyl和floramat,其可单独使用或彼此混合使用。
对于着色剂,可使用适宜的并可用于化妆品目的的物质,如记录在,例如,Farbstoffkommission der Deutschen Forschungsgemeinschaft的出版物″Kosmetische″,Verlag Chemie,Weinheim,1984,第81-106页中的。通常,着色剂的使用浓度为0.001-0.1重量%,以总混合物计。
细菌-抑制剂的典型实例为对革兰氏阳性细菌具有特定作用的防腐剂,例如洗必泰(1,6-二(4-氯苯基-二胍基)己烷)或TCC(3,4,4′-三氯碳酰苯胺)。很多芳族物质和香精油也具有抗微生物性能。典型实例为丁香油、薄荷油和百里香油中的活性成分丁子香酚、薄荷醇和百里酚。感兴趣的天然除臭剂为萜烯醇法呢醇(3,7,11-三甲基-2,6,10-十二碳三烯-1-醇),其存在于椴树花油中以及来自Callistris intratropica的木材和/或树皮蒸汽提取物的馏分中,其又称为″蓝柏油″。已证实,单月桂酸甘油酯也是抑菌剂。额外的细菌-抑制剂的存在量通常为0.1-2重量%,以制剂固含量计。
此外,化妆品组合物可包含抗泡剂(例如有机硅)、结构化剂(structurant)(例如马来酸)、增溶剂(例如乙二醇、丙二醇、甘油或二甘醇)、遮光剂(例如胶乳、苯乙烯/PVP或苯乙烯/丙烯酰胺共聚物)、络合剂(例如EDTA、NTA、β-丙氨酸二乙酰乙酸或膦酸)、推进剂(例如丙烷/丁烷混合物、N2O、二甲基醚、CO2、N2或空气)作为辅助剂,所谓的成色剂和显影剂组分作为氧化染料前体,还原剂(例如巯基乙酸及其衍生物、硫代乳酸、半胱胺、硫代苹果酸或α-巯基乙烷磺酸)、或氧化试剂(例如过氧化氢、溴酸钾或溴酸钠)。
本发明的化妆品配料包含在广泛变化的化妆品制剂中。开始考虑使用,例如,特别是下列制剂:
-用于使皮肤亮白、褪色或漂白的皮肤处理制剂;
-用于去除雀斑、老年斑(age spot)或肝斑或斑点的制剂或用于处理色素沉着过度的制剂;
-皮肤-护理制剂,例如皮肤-洗涤和清洗制剂,其为片状或液体皂、合成洗涤剂或洗涤糊的形式;
-皮肤-护理制剂,例如身体洗剂、皮肤乳液、多重乳液或美肤油;
-化妆品个人护理制剂,例如日霜或粉末霜形式的面部化妆品(make-up),扑面粉(松散或压实),胭脂或霜化妆品,唇部-护理制剂,例如唇膏、润唇膏、唇线笔,指甲-护理制剂,例如指甲油、指甲油去除剂、指甲硬化剂或去指皮水;
-特定的除臭剂和止汗剂或去骨痂制剂;
-光-防护制剂,例如日光乳、洗剂、霜或油,防晒霜或热带制剂、或晒后(after-sun)制剂;
-驱虫剂,例如驱虫剂油、洗剂、喷雾或棒;
-除臭剂,例如除臭剂喷雾、泵-作用喷雾,除臭剂凝胶、棒或滚搽式(roll-on);
-止汗剂,例如止汗剂棒、霜或滚搽式;
-用于清洗和护理受损皮肤的制剂,例如合成洗涤剂(固体或液体)、剥离或擦洗制剂或剥离面罩(mask);
-化学形式的去发制剂(脱毛),例如去发粉末,液体去发制剂、霜-或糊-状去发制剂,凝胶状或气溶胶状的去发制剂;
-剃须制剂,例如剃须皂、泡沫剃须膏、无泡沫剃须膏、剃须泡沫和凝胶、用于干剃须的剃前制剂、须后水或剃后洗剂;
-芬芳制剂,例如芬芳剂(科隆香水、梳妆水(eau de toilette)、芳香香水(eaude parfum)、parfum de toilette、香料)、芳香油或香料膏。
所列的最终配料可以很多形式存在,例如:
-液体制剂形式,如W/O、O/W、O/W/O、W/O/W或PIT乳液及所有类型的微乳液,
-凝胶形式,
-油、霜、乳或洗剂形式,
-化妆品形式,
-棒的形式,
-喷雾(以推进气体或泵-作用喷雾进行喷雾)或气溶胶形式,
-泡沫形式,
-糊的形式,或
-含表面活性剂的清洗制剂的形式。
作为皮肤用化妆品组合物,特别重要的有:
-用于使皮肤亮白、褪色或漂白的皮肤处理制剂;用于去除雀斑、老年斑或肝斑或斑点的制剂或用于处理色素沉着过度的制剂,例如皮肤乳、洗剂、霜、油、凝胶和喷雾以及糊或皂,例如固体或液体皂;
-光-防护制剂,例如日光乳、洗剂、霜、油、防晒霜或热带制剂、晒后制剂。其中特别感兴趣的是防晒霜、防晒洗剂、防晒油、防晒乳和喷雾形式的防晒制剂。
当本发明组合物为清洗制剂的形式时,其含有至少一种清洗物质。适宜的清洗物质为,例如,阴离子、非离子或两性离子和两性的合成清洗物质。
适宜的阴离子清洗物质为
-硫酸盐,例如烷基链长度为8-18个碳原子的脂肪醇硫酸盐,例如硫酸化的月桂醇;
-脂肪醇醚硫酸盐,例如2-30摩尔环氧乙烷与1摩尔C8-C22脂肪醇的聚加合物的酸性酯或其盐;
-作为指定的(designated)皂的C8-C20脂肪酸的碱金属、铵或胺盐,例如椰子脂肪酸;
-烷基酰胺硫酸盐;
-烷基胺硫酸盐,例如单乙醇胺月桂基硫酸盐;
-烷基酰胺醚硫酸盐;
-烷基芳基聚醚硫酸盐;
-甘油一酸酯硫酸盐;
-烷基链长度为8-20个碳原子的链烷磺酸盐,例如十二烷基磺酸盐;
-烷基酰胺磺酸盐;
-烷基芳基磺酸盐;
-α-烯烃磺酸盐;
-磺基丁二酸衍生物,例如烷基磺基丁二酸盐、烷基醚磺基丁二酸盐或烷基磺基丁二酰胺衍生物;
-下式的N-(烷基酰氨基烷基)氨基酸
其中
X为氢、C1-C4烷基或-COOM+;
Y为氢或C1-C4烷基;
Z为-(CH2)m1-1;
m1为1-5的整数;
n1为6-18的整数;且
M为碱金属或铵阳离子;
-下式的烷基和烷芳基醚羧酸盐
(34)CH3-X-Y-A
其中
R为氢、或C1-C4烷基;
Y为-(CHCHO)1-50-;
m2为1-6;且
M为碱金属或胺阳离子。
脂肪酸甲基牛磺酸盐、烷基异硫代硫酸盐、脂肪酸多肽缩合产物和脂肪醇磷酸酯也可用作阴离子表面活性剂。优选,这些化合物中的烷基具有8-24个碳原子。
通常,阴离子表面活性剂为其水溶性盐(例如碱金属、铵或胺盐)的形式。这些盐的实例为锂盐、钠盐、钾盐、铵盐、三乙胺的盐、乙醇胺的盐、二乙醇胺的盐和三乙醇胺的盐。特别使用钠盐、钾盐或铵(NR1R2R3)的盐,其中R1、R2和R3各自独立地为氢、C1-C4烷基或C1-C4羟烷基。
在本发明组合物中,非常特别优选的阴离子表面活性剂为单乙醇胺月桂基硫酸盐或脂肪醇硫酸酯的碱金属盐,特别是月桂基硫酸钠和2-4摩尔环氧乙烷与月桂基醚硫酸钠的反应产物。
对于两性离子和两性表面活性剂,开始考虑使用C8-C18甜菜碱、C8-C18磺基甜菜碱(sulfobetaine)、C8-C24烷基酰氨基-C1-C4亚烷基甜菜碱、咪唑啉羧酸酯、烷基两性羧基羧酸、烷基两性羧酸(例如月桂两性甘氨酸酯)和N-烷基-b-氨基-丙酸酯或-亚氨基二丙酸酯,优选C10-C20烷基酰氨基-C1-C4亚烷基甜菜碱且特别是椰子脂肪酸酰胺丙基甜菜碱。
对于非离子表面活性剂,适宜的有,例如,分子量为1000-15000的环氧丙烷/环氧乙烷的加合物的衍生物、脂肪醇乙氧基化物(1-50EO)、烷基酚聚乙二醇醚(1-50EO)、乙氧基化碳水化合物、脂肪酸二醇偏酯(例如二甘醇单硬脂酸酯)、脂肪酸链烷醇酰胺和二链烷醇酰胺、脂肪酸链烷醇酰胺乙氧基化物和脂肪胺氧化物。
还可这样使用饱和及不饱和的C8-C22脂肪酸的盐:单独使用、相互混合使用或与上述其它清洗物质混合使用。这些脂肪酸的实例为癸酸、月桂酸、肉豆蔻酸、棕榈酸、硬脂酸、花生酸、山萮酸、癸烯酸、十二碳烯酸、十四碳烯酸、十八碳烯酸、油酸、二十碳烯酸和芥酸、以及这些酸的工业混合物,例如椰子脂肪酸。这些酸为盐的形式,适宜的阳离子为碱金属阳离子(例如钠和钾的阳离子)、金属原子(例如锌和铝原子)或充分的与碱反应、含氮的有机化合物(例如胺或乙氧基化胺)。还可对这些盐进行原位制备。
在本发明组合物中,优选使用皂,即支化或非支化的长链烷基-或链烯基-羧酸盐,例如钠盐、钾盐、铵盐或取代的铵盐。
本发明的清洗组合物可为固体形式、凝胶、合成洗涤剂或液体配料的形式。其可根据常规方法进行制备。
根据皂类工业常用且描述于文献(参见,例如L.Spitz(Ed.),Soaps andDetergents,A Theoretical and Practical Review,AOCS Press,Champaign,III.,USA(1996))中的用于这种产品的方法来制备皂(固体皂、合成洗涤剂、液体皂)。制备固体皂中的关键因素为挤出之前的皂物质(soap mass)的强烈混合,以便实现对成分(特别是抗氧化剂)进行均匀分散。通常将抗氧化剂直接加到皂物质中,或如果期望,在对这些物质进行挤出或压缩在模内之前,将抗氧化剂预溶解在香料中、通过混合(例如在喷射流混合器中)合捏和(例如在强力捏和机中)在其中进行均匀的分散。通过在适宜的混合设备(例如来自Pfaudler的Sulzer混合器、Erestat混合器或DAT混合器)中对组分进行均化同样地制造液体皂,抗氧化剂的均匀分散通常比在固体皂的情况下更快的实现,由于配料的粘度较低。作为该方法的变形,还可任选的通过施加热,预先将抗氧化剂结合进皂坯(絮状体、面条状)中。
下列实例用于说明本发明,但并非对本发明进行限制。
实施例
配料实施例
实施例1:基本配料
制备:将组分A加热至75℃。将C1分散在C2中。
将组分B加热至75℃。在乳化之前,将组分C加入组分A中。在细心地搅拌下,将组分A加到组分B中。然后使用Ultra Turrax,进行10秒钟均化。
然后,在细心地搅拌下,将该混合物冷却至60℃,并将D2加入到乳液中。在搅拌下加入D3。进行进一步的搅拌,直至温度达到40℃。加入D1并将pH调节至6.7。
实施例2:面霜配料
制备面霜且其含有下列组分:
3.0重量%的单硬脂酸甘油酯,
1.5重量%的蜂蜡,
0.5重量%的脱水山梨糖醇单油酸酯,
5.0重量%的凡士林,液体
10.0重量%的石蜡,
1.0重量%的卵磷脂,
0.5重量%的N-硬脂酰-L-谷氨酸钠,
0.15重量%的黄原胶,
0.2重量%的式(3)化合物,
0.1重量%的曲酸,
0.1重量%的对羟基苯甲酸甲酯,和
补加水以达到100重量%。
实施例3:喷雾配料
0.1-0.5重量%的式(3)化合物
0.5-0.1重量%的曲酸;
2.0重量%的增溶剂(solubilisant)LRI(LCW),
70重量%的乙醇abs
补加水以达到100重量%。
实施例4:水包油配料:
0.05-0.5重量%的式(3)化合物和不同的皮肤-亮白物质;
0.05-5重量%的一种或多种UV吸收剂;
12重量%的硬脂酸甘油酯;
6重量%的石蜡油;
6重量%的辛酸/癸酸甘油三脂;
4重量%的甘油;
0.2重量%的二钠EDTA
1.0重量%的柠檬酸酯,和
补加水以达到100重量%。
实施例5:片皂配料
INCI名称 活性皂
%(如所供应的)
式(3)的羟基二苯基醚化合物 0.5
二氧化钛 0.2
四钠EDTA 0.023
硬脂酸 3.0
甘油-水 适量
Vibracolor Green PGR7-1 0.004
Vibracolor Red PRE5-L --
皂条 补加以达到100
实施例6:皂配料的半侧比较(half-side comparison)
20名亚洲受检者(中国、印度支那,分别均具有在8L*和b*值内的L*和b*值)的组,每天以皂a)和b)及以皂c)和d)清洗测试部位两次,每次30-40秒,30秒后进行冲洗。
在第一次处理之前和在第4、6、8和12个星期,对处理组在前臂和小腿上的测试部位的色值进行测定并取平均。
以盲检的方法使用这些皂;将这些皂随机分配至左侧或右侧。
使用下列皂组合物:
a)含有0.3%的式(3)化合物的皂
b)含有(无活性成分)的对照皂
c)含有0.3%式(FW-22)化合物的对照皂
d)具有Immediate White(0.3%式(FW-22)化合物和0.3%式(3)化合物)的皂。
测试结果显示在表6中。
配料:
将混合物搅拌进皂条中,然后加入剩余物质,其中该混合物包含下列物质:(单位为%)
式(3)化合物 10份
式(FW-22)化合物 10份
式(AO 26)化合物 1份。
成分 | (a) | (b) | (d) |
氧化钛 | 0.2 | 0.2 | 0.2 |
四钠EDTA | 0.023 | 0.023 | 0.023 |
甘油-水 | 适量 | 适量 | 适量 |
硬脂酸 | 3.0 | 3.0 | 3.0 |
Vibracolor Green PGR7-1 | 0.004 | - | - |
Vibracolor Red PRE5-L | - | - | 0.004 |
羟基二苯基醚化合物 | 0.3 | ||
Immediate White | 0.63 | ||
抗氧化剂(Tinogard TT) | 0.02 | 0.02 | |
皂条 | 补加以达到100 | 补加以达到100 | 补加以达到100 |
因此,本发明包括:
1.(a)式(1)的卤代羟基二苯基醚化合物在制备作为黑素生成抑制剂和用于皮肤亮白的组合物中的用途
Y为氯或溴,
Z为SO2H、NO2、或C1-C4烷基;
m为0或1;
n为1或2;
r为0-3;
o为1-3;且
p为0、1或2。
2.项1的用途,其中在式(1)中
m为0或1;
n为1或2;
o为1-3;
p为0或1;且
r为1或2。
3.项1或2的用途,其中该羟基二苯基醚化合物对应于下式
其中
m为0或1;
o为1-3;且
r为1或2。
4.项3的用途,其中在式(2)中
m为0;
且o和r与项3所限定的相同。
5.项3或4的用途,其中
o为1或2;且
r为1。
6.项1-5中任一项的用途,其中该羟基二苯基醚化合物对应于下式
7.项1-5中任一项的用途,其中该羟基二苯基醚化合物对应于下式
8.项1-7中任一项的用途,其中式(1)的羟基二苯基醚化合物同时用于皮肤和粘膜以及外皮附属物(毛发)的抗微生物处理。
9.项1-8中任一项的用途,其中还使用其它皮肤-亮白物质作为组分(b)。
10.项1-9中任一项的用途,其中组分(b)选自曲酸、熊果苷、栎精、芦荟苦素、壬二酸、愈创醇、鞣花酸及其酯化合物和荧光增白剂。
11.项1-10中任一项的用途,其中组分(a)∶(b)的重量比为1∶99。
12.项1-11中任一项的用途,其中该组合物还包含一种或多种UV-A和/或UV-B吸收剂作为组分(c)。
13.项12的用途,其中使用下式化合物作为UV-A或UV-B吸收剂
其中
R1和R2各自独立地为C1-C18烷基、C2-C18链烯基、式-CH2-CH(-OH)-CH2-O-T1的基团;或
R16为C1-C5烷基;
m1和m3各自独立地为1-4;
p1为0或1-5的数;
R5为氢、或甲基;
T1为氢、或C1-C8烷基;
Q1为C1-C18烷基;
M为金属阳离子;
m2为1-4;且
n1为1-16。
14.项12或13的用途,其中该组合物包含下式化合物作为组分(c)
15.项12或13的用途,其中该组合物包含下式化合物作为组分(c)
16.项12的用途,其中该组合物包含下式化合物作为组分(c)
T2为C1-C12烷基。
17.项16的用途,其中T2为异辛基。
18.项12的用途,其中该组合物包含甲氧基肉桂酸辛酯作为组分(c)。
19.项12的用途,其中该组合物包含二苯甲酮-3作为组分(c)。
20.项1-19中任一项的组合物的用途,其中所述组合物是化妆品配料。
21.项20的用途,其中该组合物以水包油配料的形式、以溶剂配料或以糊配料的形式使用。
22.一种化妆品配料,包含
(a)式(1)的化合物、和一种或多种组分(b)和/或(c);
(b)其它皮肤-亮白活性成分,选自
吡喃酮衍生物、氢醌、氢醌糖苷、苷形式的氢醌衍生物、间苯二酚衍生物、甘氨酸、谷胱甘肽、乙酰半胱氨酸、低聚肽、烷基二羧酸、1,2-二羟基苯基衍生物、脲、尿囊素、呋喃酮、苯乙醛、苯甲醛、4-甲氧基肉桂醛、异构的癸烯酸、酚类物质、苯并[b]吡喃衍生物、冰片基和肉桂酸酯衍生物、薁及其衍生物、细胞信使物质、荧光增白剂、及式和的化合物,
(c)一种或多种UV-A和/或UV-B吸收剂,
和任选的
(d)抗氧化剂以及化妆品可接受的辅助剂或载体。
23.项22的化妆品配料,含有
0.001-10重量%的组分(a),
0-10重量%的组分(b),
0-30重量%的组分(c),和
0-30重量%的组分(d)。
24.清洗组合物,包含
0.05-2重量%的选自式(3)或(4)的化合物的组分(a),
0.001-2重量%的组分(b),
0-2重量%的组分(c),
0-2重量%的组分(d),和
0.1-10重量%的一种或多种合成洗涤剂或皂或这种物质的组合,其中
组分(b)、(c)和(d)与项22所限定的相同。
25.项22的化妆品配料,其中组分(b)选自曲酸、α-熊果苷、栎精、芦荟苦素、壬二酸、愈创醇、鞣花酸及其酯以及式(FW-22)的荧光增白剂,
其中式(FW-22)的荧光增白剂为
Claims (19)
5.权利要求1-4中任一项的用途,其中式(1)的卤代羟基二苯基醚化合物同时用于皮肤和粘膜以及外皮附属物的抗微生物处理。
6.权利要求5中的用途,其中外皮附属物为毛发。
7.权利要求1-4中任一项的用途,其中还使用其它皮肤-亮白物质作为组分(b)。
8.权利要求7的用途,其中组分(b)选自曲酸、熊果苷、栎精、芦荟苦素、壬二酸、愈创醇、鞣花酸及其酯化合物和荧光增白剂。
9.权利要求7的用途,其中组分(a)∶(b)的重量比为1∶99,其中组分(a)为式(1)的卤代羟基二苯基醚化合物。
10.权利要求1-4中任一项的用途,其中该组合物还包含一种或多种UV-A和/或UV-B吸收剂作为组分(c)。
11.权利要求10的用途,其中使用下式化合物作为UV-A或UV-B吸收剂
其中
R1和R2各自独立地为C1-C18烷基、C2-C18链烯基、式-CH2-CH(-OH)-CH2-O-T1的基团;或
R13、R14和R15各自独立地为C1-C18烷基、C1-C18烷氧基或式的基团
R16为C1-C5烷基;
m1各自独立地为1-4;
p1为0或1-5的数;
R5为氢、或甲基;
T1为氢、或C1-C8烷基;
Q1为C1~C18烷基;
M为金属阳离子;
m2为1-4;且
n1为1-16。
12.权利要求10的用途,其中该组合物包含下式化合物作为组分(c)
15.权利要求14的用途,其中T2为异辛基。
16.权利要求10的用途,其中该组合物包含甲氧基肉桂酸辛酯作为组分(c)。
17.权利要求10的用途,其中该组合物包含二苯甲酮-3作为组分(c)。
18.权利要求1-4中任一项的组合物的用途,其中所述组合物是化妆品配料。
19.权利要求18的用途,其中该组合物以水包油配料的形式、以溶剂配料或以糊配料的形式使用。
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
EP03405542 | 2003-07-16 | ||
EP03405542.6 | 2003-07-16 | ||
PCT/EP2004/051379 WO2005013931A1 (en) | 2003-07-16 | 2004-07-07 | Use of halogenated hydroxydiphenyl ether compounds for the treatment of the skin |
Publications (2)
Publication Number | Publication Date |
---|---|
CN1852697A CN1852697A (zh) | 2006-10-25 |
CN1852697B true CN1852697B (zh) | 2010-10-13 |
Family
ID=34130394
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
CN2004800264517A Expired - Fee Related CN1852697B (zh) | 2003-07-16 | 2004-07-07 | 卤代羟基二苯基醚化合物在皮肤处理中的应用 |
Country Status (7)
Country | Link |
---|---|
US (3) | US20060216252A1 (zh) |
EP (1) | EP1648400A1 (zh) |
JP (1) | JP2007526893A (zh) |
KR (1) | KR20060033005A (zh) |
CN (1) | CN1852697B (zh) |
TW (1) | TW200519079A (zh) |
WO (1) | WO2005013931A1 (zh) |
Families Citing this family (7)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
DE102005026035A1 (de) * | 2005-06-03 | 2006-12-07 | Beiersdorf Ag | Kosmetische Zubereitungen mit einem Gehalt an einem besonderen Anisfruchtextrakt und Füllstoffen |
WO2009022430A1 (en) * | 2007-08-10 | 2009-02-19 | Ki Pharmaceuticals, Inc. | Skin whitening agent |
DE102009048976A1 (de) * | 2009-10-09 | 2011-04-14 | Beiersdorf Ag | Kosmetische oder dermatologische Zubereitung mit Kombinationen aus 4-n-Butylresorcin und einem oder mehreren Stearinsäureesten |
DE102009048975A1 (de) * | 2009-10-09 | 2011-04-14 | Beiersdorf Ag | Verwendung von 4-n-Butylresorcin zur Verhinderung oder Verminderung der Diffusion eines oder mehrerer Bestandteile kosmetischer Zubereitung, insbesondere Emulsionen in das die Zubereitung umgebenden Behältermaterial, insbesondere Tuben |
FR2973231B1 (fr) * | 2011-04-01 | 2013-12-20 | Oreal | Utilisation comme antipelliculaire de composes (ethoxyhydroxyphe-nyl)alkylcetone ou ethoxyhydroxyalkylphenol |
CN103666887B (zh) * | 2013-03-24 | 2015-04-15 | 上海巴方精细化工有限公司 | 芦荟低刺激护肤香皂 |
US10864154B2 (en) * | 2018-04-03 | 2020-12-15 | Sami Labs Limited | Skin care compositions and their applications |
Citations (3)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
DE2020968A1 (de) * | 1970-04-29 | 1971-11-18 | Henkel & Cie Gmbh | Bactericide Seife |
US3753914A (en) * | 1970-08-08 | 1973-08-21 | Henkel & Cie Gmbh | Synergistic bleaching textile treating compositions with an antimicrobial action |
US5399785A (en) * | 1992-08-05 | 1995-03-21 | Nippon Paint Co., Ltd. | Tyrosinase activity inhibitor |
Family Cites Families (12)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
NL133434C (zh) * | 1963-02-22 | 1972-02-15 | ||
JPH0678935A (ja) * | 1992-09-04 | 1994-03-22 | Olympus Optical Co Ltd | 歯科補綴物 |
JPH06321765A (ja) * | 1993-05-18 | 1994-11-22 | Kao Corp | 美白剤 |
ATE179883T1 (de) * | 1993-07-03 | 1999-05-15 | Procter & Gamble | Persönliches reinigungsmittel |
DE19543730A1 (de) * | 1995-11-23 | 1997-05-28 | Ciba Geigy Ag | Bis-Resorcinyl-Triazine |
CN1117737C (zh) * | 1996-11-20 | 2003-08-13 | 西巴特殊化学品控股有限公司 | 对称三嗪衍生物 |
DE69942567D1 (de) * | 1998-11-02 | 2010-08-19 | Basf Se | Stabilisierung von körperpflegemittel und haushaltsmitteln |
EP1068866A3 (de) * | 1999-07-12 | 2004-03-17 | Ciba SC Holding AG | Verwendung von Mischungen aus Mikropigmenten zur Bräunungsverhinderung und Aufhellung der Haut und Haare |
DE60037135T2 (de) * | 1999-12-13 | 2008-09-11 | Ciba Specialty Chemicals Holding Inc. | Verwendung von optischen aufhellern |
CN1394135A (zh) * | 2000-01-10 | 2003-01-29 | 西巴特殊化学品控股有限公司 | 微生物包封的材料在化妆品最终配方中的应用 |
GB0006867D0 (en) * | 2000-03-21 | 2000-05-10 | Unilever Plc | Method and composition for skin lightening |
WO2002087565A1 (en) * | 2001-05-02 | 2002-11-07 | New York University | Inhibition of pigmentation by inhibition of fatty acid synthase |
-
2004
- 2004-07-07 EP EP04766137A patent/EP1648400A1/en not_active Ceased
- 2004-07-07 CN CN2004800264517A patent/CN1852697B/zh not_active Expired - Fee Related
- 2004-07-07 KR KR1020067000417A patent/KR20060033005A/ko not_active Application Discontinuation
- 2004-07-07 US US10/564,712 patent/US20060216252A1/en not_active Abandoned
- 2004-07-07 JP JP2006519916A patent/JP2007526893A/ja active Pending
- 2004-07-07 WO PCT/EP2004/051379 patent/WO2005013931A1/en active Application Filing
- 2004-07-14 TW TW093120953A patent/TW200519079A/zh unknown
-
2008
- 2008-06-19 US US12/214,490 patent/US20080260667A1/en not_active Abandoned
- 2008-06-24 US US12/214,998 patent/US20080279794A1/en not_active Abandoned
Patent Citations (3)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
DE2020968A1 (de) * | 1970-04-29 | 1971-11-18 | Henkel & Cie Gmbh | Bactericide Seife |
US3753914A (en) * | 1970-08-08 | 1973-08-21 | Henkel & Cie Gmbh | Synergistic bleaching textile treating compositions with an antimicrobial action |
US5399785A (en) * | 1992-08-05 | 1995-03-21 | Nippon Paint Co., Ltd. | Tyrosinase activity inhibitor |
Non-Patent Citations (1)
Title |
---|
JP特开平6-321765A 1994.11.22 |
Also Published As
Publication number | Publication date |
---|---|
WO2005013931A1 (en) | 2005-02-17 |
CN1852697A (zh) | 2006-10-25 |
EP1648400A1 (en) | 2006-04-26 |
KR20060033005A (ko) | 2006-04-18 |
WO2005013931B1 (en) | 2005-04-07 |
US20080279794A1 (en) | 2008-11-13 |
JP2007526893A (ja) | 2007-09-20 |
US20080260667A1 (en) | 2008-10-23 |
TW200519079A (en) | 2005-06-16 |
US20060216252A1 (en) | 2006-09-28 |
Similar Documents
Publication | Publication Date | Title |
---|---|---|
CN102858916B (zh) | 通过使用含植物提取物的苯并环庚三烯酚酮和/或相关苯并环庚三烯酚酮衍生物稳定家用、护体和食品产品 | |
CN101808615B (zh) | 包含苯并三唑和部花青的混合物 | |
CN105380810B (zh) | 化妆品组合物的稳定 | |
CN1902353B (zh) | 经稳定的身体护理品、家用制品、纺织品和织物 | |
KR101835140B1 (ko) | 탄화수소 혼합물 및 이의 용도 | |
CN101711151B (zh) | Uv-敏感活性成分的稳定作用 | |
CN100475799C (zh) | 化妆用部花青衍生物 | |
TWI484979B (zh) | 身體保養品與家用品之穩定化 | |
CN106163492B (zh) | 化妆品uv吸收剂的混合物 | |
KR20230019487A (ko) | 활성 혼합물 | |
CN101854904B (zh) | 化妆品组合物的稳定化 | |
CN106999376B (zh) | 用于化妆品配制剂中的uv过滤剂的增溶剂 | |
CN102238983A (zh) | 苯并环庚三烯酚酮衍生物作为uv吸收剂和抗氧化剂的用途及其在防晒剂和/或化妆品组合物中的用途 | |
JP2005513072A (ja) | 高濃縮された、易流動性の真珠光沢剤濃縮物 | |
CN107922882A (zh) | 香料混合物 | |
CN104582681A (zh) | 聚氧化烯取代亚烷基二胺及其在皮肤和头发上的用途 | |
EP3383354A1 (en) | Delivery system for active agents | |
CN1933801A (zh) | (2-羟苯基)醇的用途和含有该化合物的化妆品或治疗制剂 | |
CN116634990A (zh) | 包含一种或多种(生物)-链烷二醇与活性组分的组合物 | |
US20220142877A1 (en) | Cosmetic or personal care formulations containing porous metal oxide spheres | |
CN1852697B (zh) | 卤代羟基二苯基醚化合物在皮肤处理中的应用 | |
CN102007137B (zh) | 烷基(聚)糖苷和/或烯基(聚)糖苷的烷基醚和/或烯基醚及其用途 | |
CN106102707B (zh) | 用于化妆品配制剂中的uv过滤剂的增溶剂 | |
JP2009501186A (ja) | 防腐剤 | |
CN101277674B (zh) | 使用部花青衍生物使身体护理产品和家用产品稳定化防止uv辐射引起的降解 |
Legal Events
Date | Code | Title | Description |
---|---|---|---|
C06 | Publication | ||
PB01 | Publication | ||
C10 | Entry into substantive examination | ||
SE01 | Entry into force of request for substantive examination | ||
C14 | Grant of patent or utility model | ||
GR01 | Patent grant | ||
CF01 | Termination of patent right due to non-payment of annual fee | ||
CF01 | Termination of patent right due to non-payment of annual fee |
Granted publication date: 20101013 Termination date: 20200707 |