CN1850111A - Biodegradeable hemostasis powder - Google Patents
Biodegradeable hemostasis powder Download PDFInfo
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- CN1850111A CN1850111A CN 200610024198 CN200610024198A CN1850111A CN 1850111 A CN1850111 A CN 1850111A CN 200610024198 CN200610024198 CN 200610024198 CN 200610024198 A CN200610024198 A CN 200610024198A CN 1850111 A CN1850111 A CN 1850111A
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- sodium alginate
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Abstract
The present invention relates to a hemostatic powder which has high swelling rate and can be bio-degradable. It is made up by using carboxymethl chitosan, sodium alginate and calcium chloride as main raw material, through a certain preparation process.
Description
Technical field
The present invention relates to medical technical field, is the well also biodegradable styptic powder of a kind of swelling ratio height, haemostatic effect.
Background technology
Hemorrhage is the primary cause of death in the war wound, is the deputy cause of death in the wound.Hemorrhage still wounded patient operating room main causes of death.Control over bleeding can obviously reduce the death that causes because of hemorrhage quickly and efficiently.
The powdery agent for stanching is not subjected to the restriction at wound surface size and position, and its original advantage is arranged, and will further widen its scope of application after increasing biodegradable characteristic.External at present biodegradable styptic powder such as the ARISTA that develops
TM, be that a kind of particle diameter is 10-200 μ m with the polysaccharide microsphere potato starch purification processing, that have many micropore surfaces structure, its moisture content in can fast Absorption blood concentrates thrombin and platelet, promotes blood clotting.Haemostatic effect is better, but costs an arm and a leg.The present domestic similar products that still do not have.
Summary of the invention
The invention provides a kind of biodegradable styptic powder, also is a kind of polysaccharide microsphere, but its main component is carboxymethyl chitosan and sodium alginate.Chitosan is the biological polysaccharide of two kinds of different hemostatic mechanisms with alginic acid, all has the biodegradability and the favorable tissue compatibility, but their haemostatic effects separately are limited.The present invention is with these two kinds of biomaterials that hemostatic mechanism is different, prepare have many fold surface, the microsphere of water absorption and swelling fast, obtain good haemostatic effect.
Styptic powder of the present invention is prepared from by carboxymethyl chitosan, sodium alginate, calcium chloride and water, liquid paraffin and Tween 80, and wherein calcium chloride is cross-linking agent, the Tween 80 emulsifying agent.Each proportioning components is:
Carboxymethyl cellulose 1～2g sodium alginate 1～2g
Calcium chloride 0.8～1.6g liquid paraffin 250～1000ml
Tween 80 18～75ml
Preparation method:
1. preparation aqueous phase solution: by proportioning carboxymethyl chitosan and sodium alginate are dissolved in 100～200ml distilled water separately and are mixed with aqueous solution.Get equivalent carboxymethyl chitosan sugar juice and sodium alginate soln, fully stirring is mixed, makes aqueous phase solution;
2. preparation oil-phase solution: with liquid paraffin and Tween 80 mixing, make oil-phase solution by proportioning;
3. preparation calcium chloride solution: calcium chloride is dissolved in 25～50ml distilled water gets final product;
4. preparation hydrogel microsphere: aqueous phase solution is added oil-phase solution, and stirring and emulsifying adds calcium chloride solution again and fully stirs fast, is cross-linked to form hydrogel microsphere, staticly settles, and abandons supernatant;
5. washing dehydration, preparation dry powder: will precipitate and use petroleum ether, removal liquid paraffin and Tween 80, reuse ethanol degree of passing dewaters, and final drying becomes powder.
With AccuSizer780/SIS (U.S. PSS company) particle size determination systematic survey styptic powder particle diameter, between 10-100 μ m.Scanning electron microscope shows that granule is chondritic, and the surface is covered with fold.With wound fluid simulated body fluid environment, the granule swelling ratio reached 280% in the time of 3 minutes, and in rabbit splenorrhagia model, haemostatic effect obviously is better than YUNNAN BAIYAO.
The specific embodiment
Now in conjunction with the embodiments, the present invention is described in detail:
Embodiment: 1g sodium alginate and 1g carboxymethyl chitosan are dissolved in respectively in the 100ml distilled water.The carboxymethyl chitosan sugar juice is added sodium alginate soln, fully mix.Add then in the emulsion that the liquid paraffin of 500ml+37.5ml Tween 80 forms and stirred 30 minutes fast, mixing speed is 800-1000 rev/min.Add 2% calcium chloride solution 40ml again, fully stir, be cross-linked to form hydrogel microsphere, staticly settle, abandon supernatant.Use the 100ml petroleum ether respectively 3 times, become powder with 35%, 70%, 100% degree of passing dehydration of alcohol, vacuum drying respectively again.
Styptic powder of the present invention, preparation method is simple, low production cost, water absorption and swelling rate height, easy to use, haemostatic effect is good.
Claims (1)
1. a biodegradable styptic powder is characterized in that being prepared from by carboxymethyl chitosan, sodium alginate, calcium chloride and liquid paraffin and Tween 80, and each proportioning components is:
Carboxymethyl cellulose 1～2g sodium alginate 1～2g
Calcium chloride 0.8～1.6g liquid paraffin 250～1000ml
Tween 80 18～75ml
Preparation method is as follows:
(1) preparation aqueous phase solution: by proportioning carboxymethyl chitosan and sodium alginate are dissolved in 100～200ml distilled water separately and are mixed with aqueous solution, get equivalent carboxymethyl chitosan sugar juice and sodium alginate soln, fully stir mixedly, make aqueous phase solution;
(2) preparation oil-phase solution: with liquid paraffin and Tween 80 mixing, make oil-phase solution by proportioning;
(3) preparation calcium chloride solution: calcium chloride is dissolved in 25～50ml distilled water is mixed with calcium chloride solution;
(4) preparation hydrogel microsphere: aqueous phase solution is added oil-phase solution, and stirring and emulsifying adds calcium chloride solution again and fully stirs fast, is cross-linked to form hydrogel microsphere, staticly settles, and abandons supernatant;
(5) washing dehydration, preparation dry powder: will precipitate and use petroleum ether, to remove liquid paraffin and Tween 80, reuse ethanol degree of passing dewaters, and final drying becomes powder.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CNB2006100241982A CN100367933C (en) | 2006-02-28 | 2006-02-28 | Biodegradeable hemostasis powder |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CNB2006100241982A CN100367933C (en) | 2006-02-28 | 2006-02-28 | Biodegradeable hemostasis powder |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| CN1850111A true CN1850111A (en) | 2006-10-25 |
| CN100367933C CN100367933C (en) | 2008-02-13 |
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| Application Number | Title | Priority Date | Filing Date |
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| CNB2006100241982A Active CN100367933C (en) | 2006-02-28 | 2006-02-28 | Biodegradeable hemostasis powder |
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Cited By (17)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN102309776A (en) * | 2011-09-05 | 2012-01-11 | 北京博恩康生物科技有限公司 | A kind of powdery absorbable hemostatics and preparation method thereof |
| CN103040495A (en) * | 2013-01-21 | 2013-04-17 | 宁波健世生物科技有限公司 | Composite type radial artery tourniquet |
| CN103467771A (en) * | 2013-09-23 | 2013-12-25 | 潍坊美赫曼生物医药科技有限公司 | Preparation method and application of marine organism active hemostasis dressing |
| CN104042571A (en) * | 2014-06-25 | 2014-09-17 | 江苏大学 | Method for preparing capsaicin-loaded pH sensitive gel microsphere, and gel microsphere prepared by same |
| CN104548189A (en) * | 2015-01-28 | 2015-04-29 | 浙江三创生物科技有限公司 | Microsphere and application thereof in hemostasis of wound |
| CN104874011A (en) * | 2015-06-05 | 2015-09-02 | 青岛博益特生物材料股份有限公司 | Hemostatic and preparation method and application thereof |
| CN104922723A (en) * | 2015-05-28 | 2015-09-23 | 上海建华精细生物制品有限公司 | Microporous hemostatic powder with coupling of plant starch and chitosan oligosaccharide and preparation method |
| CN105169459A (en) * | 2015-10-26 | 2015-12-23 | 广东泰宝医疗科技股份有限公司 | Polysaccharide hemostat and preparation method thereof |
| CN105999382A (en) * | 2016-07-02 | 2016-10-12 | 河南驼人贝斯特医疗器械有限公司 | Chitosan bleeding stopping and pain relieving powder and preparation method thereof |
| CN106110381A (en) * | 2016-07-02 | 2016-11-16 | 河南驼人贝斯特医疗器械有限公司 | A kind of chitosan styptic powder and preparation method thereof |
| WO2017077525A1 (en) | 2015-11-08 | 2017-05-11 | Omrix Biopharmaceuticals Ltd. | Hemostatic composition |
| CN107596431A (en) * | 2017-09-29 | 2018-01-19 | 温州生物材料与工程研究所 | A kind of natural glycan Quito functional microsphere and Preparation method and use |
| CN108926735A (en) * | 2018-08-06 | 2018-12-04 | 中国热带农业科学院农产品加工研究所 | Modification of chitosan-alginate-Resina Draconis composite Nano hemostatic material and preparation method thereof |
| CN109517225A (en) * | 2018-11-26 | 2019-03-26 | 温州生物材料与工程研究所 | Hole-hole composite micro-nano structure polysaccharide microsphere and preparation method |
| CN111012942A (en) * | 2020-02-05 | 2020-04-17 | 重庆理工大学 | Hemostatic microsphere for bleeding of artery and vein and viscera and preparation method thereof |
| CN112870430A (en) * | 2021-02-02 | 2021-06-01 | 四川大学 | Composite gel hemostatic powder based on natural polysaccharide, and preparation method and application thereof |
| CN113908328A (en) * | 2021-09-10 | 2022-01-11 | 浙江海洋大学 | Antibacterial hemostatic porous microsphere based on sodium alginate and nanocrystalline cellulose |
Family Cites Families (4)
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|---|---|---|---|---|
| US6706690B2 (en) * | 1999-06-10 | 2004-03-16 | Baxter Healthcare Corporation | Hemoactive compositions and methods for their manufacture and use |
| JP3805654B2 (en) * | 2001-08-29 | 2006-08-02 | 株式会社ネクスト | Fine particles of biopolymers that prevent hemostasis and adhesion |
| CN1167366C (en) * | 2002-04-17 | 2004-09-22 | 苗九昌 | Chitosan collagen and calcium alginate compounded spongy biological dressing and its preparation process |
| CN1228371C (en) * | 2003-12-02 | 2005-11-23 | 武汉大学 | Preparation method and uses of carboxymethyl chitosan and sodium alginate blend microcapsule |
-
2006
- 2006-02-28 CN CNB2006100241982A patent/CN100367933C/en active Active
Cited By (29)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN102309776A (en) * | 2011-09-05 | 2012-01-11 | 北京博恩康生物科技有限公司 | A kind of powdery absorbable hemostatics and preparation method thereof |
| CN103040495A (en) * | 2013-01-21 | 2013-04-17 | 宁波健世生物科技有限公司 | Composite type radial artery tourniquet |
| CN103467771A (en) * | 2013-09-23 | 2013-12-25 | 潍坊美赫曼生物医药科技有限公司 | Preparation method and application of marine organism active hemostasis dressing |
| CN103467771B (en) * | 2013-09-23 | 2016-03-16 | 潍坊美赫曼生物医药科技有限公司 | A kind of preparation method and its usage of marine bioactivity bleeding-stopping dressing |
| CN104042571A (en) * | 2014-06-25 | 2014-09-17 | 江苏大学 | Method for preparing capsaicin-loaded pH sensitive gel microsphere, and gel microsphere prepared by same |
| CN104548189A (en) * | 2015-01-28 | 2015-04-29 | 浙江三创生物科技有限公司 | Microsphere and application thereof in hemostasis of wound |
| CN104922723A (en) * | 2015-05-28 | 2015-09-23 | 上海建华精细生物制品有限公司 | Microporous hemostatic powder with coupling of plant starch and chitosan oligosaccharide and preparation method |
| CN104874011A (en) * | 2015-06-05 | 2015-09-02 | 青岛博益特生物材料股份有限公司 | Hemostatic and preparation method and application thereof |
| CN105169459A (en) * | 2015-10-26 | 2015-12-23 | 广东泰宝医疗科技股份有限公司 | Polysaccharide hemostat and preparation method thereof |
| CN105169459B (en) * | 2015-10-26 | 2019-10-25 | 广东泰宝医疗科技股份有限公司 | A kind of polysaccharide styptic powder and preparation method thereof |
| US10137221B2 (en) | 2015-11-08 | 2018-11-27 | Omrix Biopharmaceuticals Ltd. | Hemostatic mixture of cellulose-based short and long fibers |
| US11007301B2 (en) | 2015-11-08 | 2021-05-18 | Omrix Biopharmaceuticals Ltd. | Hemostatic mixture of cellulose-based short and long fibers |
| US10137220B2 (en) | 2015-11-08 | 2018-11-27 | Omrix Biopharmaceuticals Ltd. | Hemostatic composition |
| WO2017077525A1 (en) | 2015-11-08 | 2017-05-11 | Omrix Biopharmaceuticals Ltd. | Hemostatic composition |
| US11712495B2 (en) | 2015-11-08 | 2023-08-01 | Omrix Biopharmaceuticals Ltd. | Hemostatic mixture of cellulose-based short and long fibers |
| US11007300B2 (en) | 2015-11-08 | 2021-05-18 | Omrix Biopharmaceuticals Ltd. | Hemostatic composition |
| US10960105B2 (en) | 2015-11-08 | 2021-03-30 | Omrix Biopharmaceuticals Ltd. | Hemostatic composition |
| CN106110381A (en) * | 2016-07-02 | 2016-11-16 | 河南驼人贝斯特医疗器械有限公司 | A kind of chitosan styptic powder and preparation method thereof |
| CN105999382A (en) * | 2016-07-02 | 2016-10-12 | 河南驼人贝斯特医疗器械有限公司 | Chitosan bleeding stopping and pain relieving powder and preparation method thereof |
| CN107596431A (en) * | 2017-09-29 | 2018-01-19 | 温州生物材料与工程研究所 | A kind of natural glycan Quito functional microsphere and Preparation method and use |
| CN107596431B (en) * | 2017-09-29 | 2021-02-19 | 温州生物材料与工程研究所 | Natural polysaccharide-based multifunctional microspheres and preparation method and application thereof |
| CN108926735A (en) * | 2018-08-06 | 2018-12-04 | 中国热带农业科学院农产品加工研究所 | Modification of chitosan-alginate-Resina Draconis composite Nano hemostatic material and preparation method thereof |
| CN109517225A (en) * | 2018-11-26 | 2019-03-26 | 温州生物材料与工程研究所 | Hole-hole composite micro-nano structure polysaccharide microsphere and preparation method |
| CN111012942A (en) * | 2020-02-05 | 2020-04-17 | 重庆理工大学 | Hemostatic microsphere for bleeding of artery and vein and viscera and preparation method thereof |
| CN111012942B (en) * | 2020-02-05 | 2022-01-25 | 重庆理工大学 | Hemostatic microsphere for bleeding of artery and vein and viscera and preparation method thereof |
| CN112870430A (en) * | 2021-02-02 | 2021-06-01 | 四川大学 | Composite gel hemostatic powder based on natural polysaccharide, and preparation method and application thereof |
| CN112870430B (en) * | 2021-02-02 | 2022-02-01 | 四川大学 | Composite gel hemostatic powder based on natural polysaccharide, and preparation method and application thereof |
| CN113908328A (en) * | 2021-09-10 | 2022-01-11 | 浙江海洋大学 | Antibacterial hemostatic porous microsphere based on sodium alginate and nanocrystalline cellulose |
| CN113908328B (en) * | 2021-09-10 | 2023-01-24 | 浙江海洋大学 | Antibacterial hemostatic porous microsphere based on sodium alginate and nanocrystalline cellulose |
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| CN100367933C (en) | 2008-02-13 |
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Effective date of registration: 20110708 Address after: 5, building 2, building 139, 200052 Anshun Road, Shanghai Co-patentee after: Qisheng Biopreparations Co., Ltd., Shanghai Patentee after: Shanghai Haohai Biological Technology Co., Ltd. Co-patentee after: Shanghai Jianhua Fine Biological Products Co., Ltd. Address before: 5, building 2, building 139, 200052 Anshun Road, Shanghai Patentee before: Shanghai Haohai Biological Technology Co., Ltd. |