CN105999382A - Chitosan bleeding stopping and pain relieving powder and preparation method thereof - Google Patents
Chitosan bleeding stopping and pain relieving powder and preparation method thereof Download PDFInfo
- Publication number
- CN105999382A CN105999382A CN201610510176.0A CN201610510176A CN105999382A CN 105999382 A CN105999382 A CN 105999382A CN 201610510176 A CN201610510176 A CN 201610510176A CN 105999382 A CN105999382 A CN 105999382A
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- chitosan
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- pain
- powder
- hemostasis
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L24/00—Surgical adhesives or cements; Adhesives for colostomy devices
- A61L24/001—Use of materials characterised by their function or physical properties
- A61L24/0015—Medicaments; Biocides
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L24/00—Surgical adhesives or cements; Adhesives for colostomy devices
- A61L24/04—Surgical adhesives or cements; Adhesives for colostomy devices containing macromolecular materials
- A61L24/08—Polysaccharides
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L24/00—Surgical adhesives or cements; Adhesives for colostomy devices
- A61L24/04—Surgical adhesives or cements; Adhesives for colostomy devices containing macromolecular materials
- A61L24/10—Polypeptides; Proteins
- A61L24/108—Specific proteins or polypeptides not covered by groups A61L24/102 - A61L24/106
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L2300/00—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices
- A61L2300/20—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices containing or releasing organic materials
- A61L2300/204—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices containing or releasing organic materials with nitrogen-containing functional groups, e.g. aminoxides, nitriles, guanidines
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L2300/00—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices
- A61L2300/20—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices containing or releasing organic materials
- A61L2300/252—Polypeptides, proteins, e.g. glycoproteins, lipoproteins, cytokines
- A61L2300/254—Enzymes, proenzymes
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L2300/00—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices
- A61L2300/40—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices characterised by a specific therapeutic activity or mode of action
- A61L2300/402—Anaestetics, analgesics, e.g. lidocaine
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L2300/00—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices
- A61L2300/40—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices characterised by a specific therapeutic activity or mode of action
- A61L2300/418—Agents promoting blood coagulation, blood-clotting agents, embolising agents
Abstract
The invention relates to chitosan bleeding stopping and pain relieving powder and a preparation method thereof. The chitosan bleeding stopping and pain relieving powder is prepared from the following components in parts by weight: 0.1 to 10 parts of carboxymethyl chitosan, 0.1 to 10 parts of sodium alginate, 0.0004 part of thrombin and 0.1 to 2 parts of lidocaine hydrochloride. The components are cross-linked by calcium chloride, washed, dried and ground into powder. The chitosan bleeding stopping and pain relieving powder and the preparation method thereof have the advantages that the preparation method is simple and green; the production cost is low; the water-absorption swelling rate is high, the convenience in use is realized, and the bleeding stopping and pain relieving effects are good.
Description
Technical field
The invention belongs to biology medical material technical field, be specifically related to a kind of chitosan hemostasis and pain-relieving powder and preparation method thereof.
Background technology
Hemorrhage is the primary cause of death in war wound, is the deputy cause of death in wound, and hemorrhage is also wounded patient operating room main causes of death, controls the hemorrhage death that can obviously reduce and cause because of Massive Bleeding quickly and efficiently；In time, quickly easing pain can significantly reduce the misery that pain is brought to wounded patient, stop blooding and lose blood to art reduces, keep that visual area is clear, prevent vital tissue damage, ensure operation safety and postoperative wound healing, reduce and infect, shorten operating time, patient's prognosis etc. is respectively provided with significance；Pain is that body comes to harm a kind of protective response produced after sexual stimulus, is often accompanied by the emotional activity such as fear, anxiety, uneasiness, makes people agonize.Have an intense pain except the not Anwai being reflected in sensorial misery and emotion, and may result in physiological dysfunction, cause insomnia, even induction is suffered a shock and threat to life, therefore, the most suitably use analgesic to alleviate severe pain and to prevent to suffer a shock be necessary, significant in treatment disease and trauma nursing.Therefore hemostatic analgesia, becomes the necessary urgent measure of Wound care.
Powdery agent for stanching is not limited by wound surface size and position, has the advantage that it is original, will widen its range further after increasing biocompatible characteristic.The most external biodegradable styptic powder such as ARISTATM developed, being a kind of potato starch purification processing, have the polysaccharide microsphere of many microporous surface structure, particle diameter is 10-200 μm, and it can quickly absorb the moisture content in blood, concentrate thrombin and platelet, promote blood clotting.Haemostatic effect is preferable, but expensive and without analgesic effect.Several families of domestic registration, many employing chitosan single component raw materials.Using emulsion-crosslinking method more in preparation technology, use organic reagent more numerous and diverse, for late-run sample processing procedure, operation is numerous and diverse, easily causes the pollution in terms of environment.The most relatively costly, expensive, and haemostatic effect is more or less the same, analgesic effect is the most inconspicuous or not this effect.
Summary of the invention
It is an object of the invention to overcome the deficiencies in the prior art, and a kind of chitosan hemostasis and pain-relieving powder that can stop blooding rapidly and preparation method thereof is provided.
The object of the present invention is achieved like this: a kind of chitosan hemostasis and pain-relieving powder, described chitosan hemostasis and pain-relieving powder is mixed to prepare by carboxymethyl chitosan, sodium alginate, thrombin, hydrochloric acid benefit card, and its weight is: carboxymethyl chitosan 0.1-10 part, sodium alginate 0.1-10 part, thrombin 0.0004 part, hydrochloric acid benefit card 0.1-2 part.
The preparation method of a kind of chitosan hemostasis and pain-relieving powder, described preparation method comprises the steps:
Step 1: be dissolved separately in 50ml distilled water by chitosan 0.1-10g and sodium alginate 0.1-10g successively and make mixed solution, by carboxymethyl chitosan solution and sodium alginate soln, is sufficiently stirred for dropping mixing, makes aqueous phase solution；
Step 2: prepare calcium chloride solution: calcium chloride 0.5-5g is dissolved in 100mL distilled water；
Step 3: calcium chloride water is added drop-wise to gained solution in step 1, dropping limit, limit is stirred；
Step 4: washing dehydration, prepares dry powder: by precipitation distilled water wash, the sodium chloride in removal system, be 5.0-7.0 to pH, is finally dried, grinds, sieves, Cheng Fen；
Step 5: add the thrombin of 0.4mg and the lidocaine hydrochloride of 0.05-2g in powdery styptic powder, ground and mixed is uniform, sterilization packaging.
Sieve in described step 4 selection 400 mesh sieves.
In described step 2, the mass fraction of calcium chloride solution is 0.5-5%.
The invention has the beneficial effects as follows: the present invention increases analgesic effect on the basis of traditional haemostatic effect, and hemostasis and pain-relieving effect is significantly improved；In preparation technology, cross-linking method, crosslinking environment is used to be purified water, be not related to any organic reagent, end processing sequences also use purified water, is not related to any organic reagent, enormously simplify process technique, drastically increase the safety of product simultaneously.
Specific embodiment
Below in conjunction with embodiment, the present invention is further illustrated.
Embodiment 1
2g sodium alginate and 0.5g carboxymethyl chitosan are dissolved in 60mL and 50mL distilled water respectively.Carboxymethyl chitosan solution is added sodium alginate soln, is thoroughly mixed.Add 1.0g calcium chloride solution 40mL, be sufficiently stirred for, be cross-linked to form aquogel system, staticly settle, abandon supernatant.With distilled water wash 3 times, it is 5.0-7.0 to pH, vacuum drying, grind, sieve, Cheng Fen, this powdery solid thing adds appropriate hydrochloric acid lignocaine 0.1g, thrombin 0.4mg, mix homogeneously, pulverizes, irradiation sterilization is packed, and becomes hemostasis and pain-relieving powder.
By the hemostasis and pain-relieving powder made in rat femoral and liver Hemorrhage Model, haemostatic effect is substantially better than YUNNAN BAIYAO and other similar products.Mice whipping is tested, it was demonstrated that analgesic effect is good.
Embodiment 2
5g sodium alginate and 1g carboxymethyl chitosan are dissolved in 150mL and 100mL distilled water respectively.Carboxymethyl chitosan solution is added sodium alginate soln, is thoroughly mixed.Add 2.5g calcium chloride solution 80mL, be sufficiently stirred for, be cross-linked to form aquogel system, staticly settle, abandon supernatant.With distilled water wash 3 times, it is 5.0-7.0 to pH, vacuum drying, grind, sieve, Cheng Fen.Adding appropriate hydrochloric acid lignocaine (0.1%), thrombin 1mg, mix homogeneously in this powdery solid thing, irradiation sterilization is packed, is become hemostasis and pain-relieving powder.
By the hemostasis and pain-relieving powder made in rat femoral and liver Hemorrhage Model, haemostatic effect is substantially better than YUNNAN BAIYAO and other similar products.Mice whipping is tested, it was demonstrated that analgesic effect is good.
Claims (4)
1. a chitosan hemostasis and pain-relieving powder, it is characterized in that: described chitosan hemostasis and pain-relieving powder is mixed to prepare by carboxymethyl chitosan, sodium alginate, thrombin, hydrochloric acid benefit card, and its weight is: carboxymethyl chitosan 0.1-10 part, sodium alginate 0.1-10 part, thrombin 0.0004 part, hydrochloric acid benefit card 0.1-2 part.
The preparation method of a kind of chitosan hemostasis and pain-relieving powder the most as claimed in claim 1, it is characterised in that: described preparation method comprises the steps:
Step 1: be dissolved separately in 50ml distilled water by chitosan 0.1-10g and sodium alginate 0.1-10g successively and make mixed solution, by carboxymethyl chitosan solution and sodium alginate soln, is sufficiently stirred for dropping mixing, makes aqueous phase solution；
Step 2: prepare calcium chloride solution: calcium chloride 0.5-5g is dissolved in 100mL distilled water；
Step 3: calcium chloride water is added drop-wise to gained solution in step 1, dropping limit, limit is stirred；
Step 4: washing dehydration, prepares dry powder: by precipitation distilled water wash, the sodium chloride in removal system, be 5.0-7.0 to pH, is finally dried, grinds, sieves, Cheng Fen；
Step 5: add the thrombin of 0.4mg and the lidocaine hydrochloride of 0.05-2g in powdery styptic powder, ground and mixed is uniform, sterilization packaging.
The preparation method of a kind of chitosan hemostasis and pain-relieving powder the most as claimed in claim 2, it is characterised in that: sieve in described step 4 selection 400 mesh sieves.
The preparation method of a kind of chitosan hemostasis and pain-relieving powder the most as claimed in claim 2, it is characterised in that: in described step 2, the mass fraction of calcium chloride solution is 0.5-5%.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201610510176.0A CN105999382A (en) | 2016-07-02 | 2016-07-02 | Chitosan bleeding stopping and pain relieving powder and preparation method thereof |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201610510176.0A CN105999382A (en) | 2016-07-02 | 2016-07-02 | Chitosan bleeding stopping and pain relieving powder and preparation method thereof |
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| Publication Number | Publication Date |
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| CN105999382A true CN105999382A (en) | 2016-10-12 |
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| Application Number | Title | Priority Date | Filing Date |
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| CN201610510176.0A Pending CN105999382A (en) | 2016-07-02 | 2016-07-02 | Chitosan bleeding stopping and pain relieving powder and preparation method thereof |
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| CN (1) | CN105999382A (en) |
Cited By (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN107754008A (en) * | 2017-12-13 | 2018-03-06 | 河南亚都实业有限公司 | A kind of chitosan hemostasis and pain-relieving powder and preparation method thereof |
| CN110755624A (en) * | 2019-11-26 | 2020-02-07 | 卢恕来 | Oral medicament for local pain relieving and bleeding stopping as well as preparation method and application thereof |
| CN113117134A (en) * | 2021-04-21 | 2021-07-16 | 石家庄亿生堂医用品有限公司 | Crosslinked chitosan hemostatic powder and preparation method thereof |
| KR20220072149A (en) * | 2020-11-25 | 2022-06-02 | 금오공과대학교 산학협력단 | Powder type hemostatic agent manufacturing method and powder type hemostatic agent thereof |
Citations (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1850111A (en) * | 2006-02-28 | 2006-10-25 | 中国人民解放军第二军医大学 | Biodegradeable hemostasis powder |
| US20070276308A1 (en) * | 2006-05-26 | 2007-11-29 | Huey Raymond J | Hemostatic agents and devices for the delivery thereof |
| CN103394078A (en) * | 2013-07-31 | 2013-11-20 | 中国人民解放军第四军医大学 | Self-pressurized multi-target collaborative hemostasis degradable hemostatic preparation for injury first aid |
-
2016
- 2016-07-02 CN CN201610510176.0A patent/CN105999382A/en active Pending
Patent Citations (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1850111A (en) * | 2006-02-28 | 2006-10-25 | 中国人民解放军第二军医大学 | Biodegradeable hemostasis powder |
| US20070276308A1 (en) * | 2006-05-26 | 2007-11-29 | Huey Raymond J | Hemostatic agents and devices for the delivery thereof |
| CN103394078A (en) * | 2013-07-31 | 2013-11-20 | 中国人民解放军第四军医大学 | Self-pressurized multi-target collaborative hemostasis degradable hemostatic preparation for injury first aid |
Cited By (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN107754008A (en) * | 2017-12-13 | 2018-03-06 | 河南亚都实业有限公司 | A kind of chitosan hemostasis and pain-relieving powder and preparation method thereof |
| CN107754008B (en) * | 2017-12-13 | 2018-07-10 | 河南亚都实业有限公司 | A kind of chitosan hemostasis and pain-relieving powder and preparation method thereof |
| CN110755624A (en) * | 2019-11-26 | 2020-02-07 | 卢恕来 | Oral medicament for local pain relieving and bleeding stopping as well as preparation method and application thereof |
| KR20220072149A (en) * | 2020-11-25 | 2022-06-02 | 금오공과대학교 산학협력단 | Powder type hemostatic agent manufacturing method and powder type hemostatic agent thereof |
| KR102465366B1 (en) | 2020-11-25 | 2022-11-10 | 금오공과대학교 산학협력단 | Powder type hemostatic agent manufacturing method and powder type hemostatic agent thereof |
| CN113117134A (en) * | 2021-04-21 | 2021-07-16 | 石家庄亿生堂医用品有限公司 | Crosslinked chitosan hemostatic powder and preparation method thereof |
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Application publication date: 20161012 |
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