CN1687499A - Blended fiber of sodium alginate/water soluble chitin, preparation method and application thereof - Google Patents
Blended fiber of sodium alginate/water soluble chitin, preparation method and application thereof Download PDFInfo
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- CN1687499A CN1687499A CN 200510018616 CN200510018616A CN1687499A CN 1687499 A CN1687499 A CN 1687499A CN 200510018616 CN200510018616 CN 200510018616 CN 200510018616 A CN200510018616 A CN 200510018616A CN 1687499 A CN1687499 A CN 1687499A
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Abstract
The present invention discloses a blend fiber of sodium alginate/ water-soluble chitin and its usage and preparation. The blend fiber of sodium alginate/ water-soluble chitin is made as following ways: Mix the solution of sodium alginate which quality percentage is 3 - 5% and the solution of water-soluble chitin which quality percentage is 3 - 5%. The gelatin contains 10 - 70% of the production (blend fiber), and then percolate it and deaerating it in low pressture. Prepare blend fiber of sodium alginate/ water-soluble chitin in coagulation fluid by means of spinning. The stretches ratio is 10 - 30%. The blend fiber has good capability of biological activity, good capability of mechanics and water-absorptivity. There are also abundant stuff and low-lying cost. It has good prospect in the domain of medicine, weave and so on, especially for chitosan nonwoven as dressing of wound.
Description
Technical field
The present invention relates to a kind of blended fiber of sodium alginate/water soluble chitin of making nonwoven fabric and its production and use that can be used for, belong to the macromolecule chemical material field.
Background technology
Alginic acid is by β-1, and 4-D-mannuronic acid and α-1, the heteroglycan that the 4-L-glucuronic acid is formed.With Ca
2+Solution is solidification liquid, and sodium alginate can be made fiber by the hygrometric state spin processes.Ca in the fiber
2+Can with the Na in the human body wound exudate
+Carry out ion-exchange and suffering from mouthful place's formation hygrometric state gel.Owing to have these two advantages of human body absorbability that can form hygrometric state wound healing environment and height, alginic acid dressing has obtained more and more widely application in today.But the elasticity of alginic acid fibre, intensity are all not ideal enough, and its financial cost is also higher.Shitosan can promote wound healing, but the rigid structure of shitosan makes them water insoluble, this has just hindered the interaction with wound, and the chitin water soluble of deacetylation about 50%, so be called as water-soluble chitosan, owing to the water-soluble of it can fully act on it with wound, studies show that it is more effective aspect the promotion wound healing.
Summary of the invention
The present invention is directed to all dissatisfactory shortcoming of elasticity, intensity of alginic acid fibre, simple and effective method by this raising macromolecular material performance of blending and modifying, with sodium alginate and the water-soluble chitosan blend that promotion wound healing function is arranged, provide a kind of combination property comparatively desirable blended fiber of sodium alginate/water soluble chitin, this blended fiber has good physiologically active, mechanical property and water absorbing properties, and the present invention also provides the method for preparing blended fiber of sodium alginate/glutin, and this method simple possible, cost are lower.
Technical scheme provided by the invention is to adopt following method to prepare blended fiber of sodium alginate/glutin:
(1) be 3～5% sodium alginate soln with the water-soluble mass percent that obtains of an amount of sodium alginate.
(2) an amount of shitosan is dissolved in 40-60% (percent by volume) methyl alcohol, 3-5% (percent by volume) acetic acid mixed aqueous solution, adding is 0.37 with the mass ratio of shitosan: 1-0.45: 1 acetic anhydride, under the room temperature stirring reaction 3-6 hour, add capacity acetone and produce precipitation, with sedimentation and filtration, desalination, the dry water-soluble chitosan that gets.
(3) be 3～5% chitin solution with the water-soluble chitosan mass percent that obtains soluble in water.
(4) with above-mentioned two kinds of solution be 10%～70% the abundant mixing of ratio in water-soluble chitosan shared quality percentage composition in product (blended fiber), after filtration, behind the vacuum deaerator, prepare blended fiber of sodium alginate/water soluble chitin with solution spinning in room temperature in the capacity solidification liquid, the tensile fiber rate is 10～30%.
Wherein used solidification liquid is for containing 5%～10% (mass percent) CaCl
2The mixed liquid of the aqueous solution and 30～50% (percent by volume) absolute ethyl alcohol.Preparation sodium alginate soln, the used water of chitin solution are preferably distilled water.
Because blended fiber of sodium alginate/water soluble chitin not only has the advantage of sodium alginate fiber and water-soluble chitosan, and mechanical property is also fine, again because of its raw material sources are abundant, low price, so be with a wide range of applications, especially be suitable for making nonwoven fabric and make wound dressing usefulness at medical field.
The specific embodiment
Embodiment 1: get the 45g sodium alginate and be dissolved in the sodium alginate soln that 855ml distilled water obtains 5% (mass percent); The 40g shitosan is dissolved in 600ml40% (percent by volume) methyl alcohol, 3% (percent by volume) acetic acid mixed aqueous solution, add the 15g acetic anhydride, stirring reaction is 6 hours under the room temperature, adds capacity acetone, and precipitation is filtered, desalination, dry water-soluble chitosan.Get the 5g water-soluble chitosan and be dissolved in the water-soluble chitosan solution that obtains 5% (mass percent) in the distilled water.With above-mentioned two kinds of abundant mixings of solution, filter, behind the vacuum deaerator, consisting of 5% (mass percent) CaCl in room temperature
2The solidification liquid of mixed liquid of the aqueous solution and 30% (percent by volume) absolute ethyl alcohol in prepare sodium alginate/water soluble crust rope fiber by solution spinning, the tensile fiber rate is 30%.
Embodiment 2: get the 35g sodium alginate and be dissolved in the sodium alginate soln that 840ml distilled water obtains 4% (mass percent); The 40g shitosan is dissolved in 600ml50% (percent by volume) methyl alcohol, 4% (percent by volume) acetic acid mixed aqueous solution, add the 17g acetic anhydride, stirring reaction is 5 hours under the room temperature, adds capacity acetone, and precipitation is filtered, desalination, dry water-soluble chitosan.Get the 15g water-soluble chitosan and be dissolved in the water-soluble chitosan solution that obtains 4% (mass percent) in the distilled water.With above-mentioned two kinds of abundant mixings of solution, filter, behind the vacuum deaerator, consisting of 7% (mass percent) CaCl in room temperature
2The solidification liquid of mixed liquid of the aqueous solution and 40% (percent by volume) absolute ethyl alcohol in prepare sodium alginate/water soluble crust rope fiber by solution spinning, the tensile fiber rate is 20%.
Embodiment 3: get the 25g sodium alginate and be dissolved in the sodium alginate soln that 808ml distilled water obtains 3% (mass percent); The 40g shitosan is dissolved in 600ml60% (percent by volume) methyl alcohol, 5% (percent by volume) acetic acid mixed aqueous solution, add the 18g acetic anhydride, stirring reaction is 3 hours under the room temperature, adds capacity acetone, and precipitation is filtered, desalination, dry water-soluble chitosan.Get the 25g water-soluble chitosan and be dissolved in the water-soluble chitosan solution that obtains 3% (mass percent) in the distilled water.With above-mentioned two kinds of abundant mixings of solution, filter, behind the vacuum deaerator, consisting of 10% (mass percent) CaCl in room temperature
2The solidification liquid of mixed liquid of the aqueous solution and 50% (percent by volume) absolute ethyl alcohol in prepare the sodium alginate/water soluble chitin fiber by solution spinning, the tensile fiber rate is 10%.
Because of solution spinning is the conventional method of preparation fiber, no longer it is elaborated here.
Embodiment 1,2,3 products therefroms are carried out mechanical property and water absorption rate test, and test result sees the following form.
By data in the table as can be known, blended fiber of sodium alginate/water soluble chitin has excellent mechanical property and water imbibition.
Claims (5)
1, a kind of blended fiber of sodium alginate/water soluble chitin is characterized in that employing is prepared as follows method and makes:
(1) be 3～5% sodium alginate soln with the water-soluble mass percent that obtains of an amount of sodium alginate.
(2) an amount of shitosan is dissolved in the mixed aqueous solution that contains 40-60% (percent by volume) methyl alcohol, 3-5% (percent by volume) acetate, adding is 0.37 with the mass ratio of shitosan: 1-0.45: 1 acetic anhydride, under the room temperature stirring reaction 3-6 hour, add capacity acetone and produce precipitation, with sedimentation and filtration, desalination, the dry water-soluble chitosan that gets.
(3) be 3～5% chitin solution with the water-soluble chitosan mass percentage content that obtains soluble in water.
(4) with above-mentioned two kinds of solution be 10%～70% the abundant mixing of ratio in water-soluble chitosan shared quality percentage composition in product (blended fiber), after filtration, behind the vacuum deaerator, prepare blended fiber of sodium alginate/water soluble chitin with solution spinning in room temperature in the capacity solidification liquid, the tensile fiber rate is 10～30%.
2, a kind of method for preparing blended fiber of sodium alginate/water soluble chitin is characterized in that adopting following steps:
(1) be 3～5% sodium alginate soln with the water-soluble mass percent that obtains of an amount of sodium alginate.
(2) an amount of shitosan is dissolved in the mixed aqueous solution that contains 40-60% (percent by volume) methyl alcohol, 3-5% (percent by volume) acetate, adding is 0.37 with the mass ratio of shitosan: 1-0.45: 1 acetic anhydride, under the room temperature stirring reaction 3-6 hour, add capacity acetone again and produce precipitation, with sedimentation and filtration, desalination, the dry water-soluble chitosan that gets.
(3) be 3～5% chitin solution with the water-soluble chitosan mass percent that obtains soluble in water.
(4) with above-mentioned two kinds of solution be 10%～70% the abundant mixing of ratio in water-soluble chitosan shared quality percentage composition in product (blended fiber), after filtration, behind the vacuum deaerator, prepare blended fiber of sodium alginate/water soluble chitin with solution spinning in room temperature in the capacity solidification liquid, the tensile fiber rate is 10～30%.
3, the method for preparing blended fiber of sodium alginate/water soluble chitin according to claim 2, it is characterized in that: solidification liquid is for containing 5%～10%CaCl
2The mixed liquid of the aqueous solution of (mass percent) and 30～50% (percent by volume) absolute ethyl alcohol.
4, the method for preparing blended fiber of sodium alginate/water soluble chitin according to claim 2 is characterized in that: preparation sodium alginate soln, the used water of chitin solution are distilled water.
5, blended fiber of sodium alginate/water soluble chitin is used to prepare nonwoven fabric as wound dressing.
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| CNB2005100186162A CN1332081C (en) | 2005-04-27 | 2005-04-27 | Blended fiber of sodium alginate/water soluble chitin, preparation method and application thereof |
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|---|---|---|---|
| CNB2005100186162A CN1332081C (en) | 2005-04-27 | 2005-04-27 | Blended fiber of sodium alginate/water soluble chitin, preparation method and application thereof |
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| CN1332081C CN1332081C (en) | 2007-08-15 |
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Cited By (14)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2007093805A1 (en) * | 2006-02-16 | 2007-08-23 | The University Of Bolton Education Corporation | Composite fibre of alginate and chitosan |
| CN100457990C (en) * | 2007-04-16 | 2009-02-04 | 青岛大学 | Producing method and use for common and functional calcium alginate fiber |
| CN101049515B (en) * | 2007-05-15 | 2010-10-13 | 浙江理工大学 | Method for preparing medical dressing of non-woven fabrics by wet-process blending chitosan and silk fibrino |
| CN102031590A (en) * | 2011-01-12 | 2011-04-27 | 武汉理工大学 | Novel method for preparing sodium alginate/hydroxypropyl chitosan antibacterial blended fiber |
| CN102552966A (en) * | 2012-01-31 | 2012-07-11 | 青岛明药堂医药科技开发有限公司 | Alginate antibacterial dressing and its preparation method |
| CN101332309B (en) * | 2006-01-12 | 2012-11-14 | 张镁 | Water soluble polyose composite medical dressing and preparation method thereof |
| CN103469365A (en) * | 2013-09-22 | 2013-12-25 | 山东颐诺生物科技有限公司 | Alginic acid-chitosan composite fiber for tranma repairing and preparation method thereof |
| CN104069536A (en) * | 2014-07-11 | 2014-10-01 | 江苏开源康达医疗器械有限公司 | Method for preparing sodium alginate-chitosan nano-grade medical dressing |
| CN106400191A (en) * | 2016-11-17 | 2017-02-15 | 无锡明盛纺织机械有限公司 | Composite fiber adopting skin-core type structure as well as preparation method and application of composite fiber |
| CN106835671A (en) * | 2016-12-22 | 2017-06-13 | 马鞍山市鑫程纳米新材料科技有限公司 | A kind of method for improving non-woven fabrics tensile strength |
| CN110241481A (en) * | 2019-05-28 | 2019-09-17 | 福建美可纸业有限公司 | A kind of superabsorbent water composite fibre and preparation method thereof |
| CN111020745A (en) * | 2019-12-31 | 2020-04-17 | 泰州市榕兴医疗用品股份有限公司 | Preparation method of sodium alginate and chitosan composite nanofiber |
| CN111434816A (en) * | 2019-01-15 | 2020-07-21 | 青岛大学 | Anti-raveling chitin fiber fabric and preparation method thereof |
| CN113648450A (en) * | 2021-08-11 | 2021-11-16 | 杭州仁世医疗器械有限公司 | Medical sterilization dressing and preparation method thereof |
Family Cites Families (3)
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| CN1080784C (en) * | 1996-12-29 | 2002-03-13 | 冯鸿城 | Active wound dressing, zinc-calcium alginate fiber nonwoven fabric and its preparing technology |
| CN1297957A (en) * | 1999-12-01 | 2001-06-06 | 武汉大学 | Preparation and use of intermingled film or fiber of carboxymethyl chitosan and alginic acid |
| CN1228371C (en) * | 2003-12-02 | 2005-11-23 | 武汉大学 | Preparation method and uses of carboxymethyl chitosan and sodium alginate blend microcapsule |
-
2005
- 2005-04-27 CN CNB2005100186162A patent/CN1332081C/en not_active Expired - Fee Related
Cited By (18)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN101332309B (en) * | 2006-01-12 | 2012-11-14 | 张镁 | Water soluble polyose composite medical dressing and preparation method thereof |
| GB2448283A (en) * | 2006-02-16 | 2008-10-08 | Univ Bolton Higher Education C | Composite fibre of alginate and chitosan |
| WO2007093805A1 (en) * | 2006-02-16 | 2007-08-23 | The University Of Bolton Education Corporation | Composite fibre of alginate and chitosan |
| GB2448283B (en) * | 2006-02-16 | 2011-09-07 | Univ Bolton Higher Education Corp | Composite fibre of alginate and chitosan |
| US8563702B2 (en) | 2006-02-16 | 2013-10-22 | The University Of Bolton Education Corporation | Composite fibre of alginate and chitosan |
| CN100457990C (en) * | 2007-04-16 | 2009-02-04 | 青岛大学 | Producing method and use for common and functional calcium alginate fiber |
| CN101049515B (en) * | 2007-05-15 | 2010-10-13 | 浙江理工大学 | Method for preparing medical dressing of non-woven fabrics by wet-process blending chitosan and silk fibrino |
| CN102031590A (en) * | 2011-01-12 | 2011-04-27 | 武汉理工大学 | Novel method for preparing sodium alginate/hydroxypropyl chitosan antibacterial blended fiber |
| CN102552966A (en) * | 2012-01-31 | 2012-07-11 | 青岛明药堂医药科技开发有限公司 | Alginate antibacterial dressing and its preparation method |
| CN103469365A (en) * | 2013-09-22 | 2013-12-25 | 山东颐诺生物科技有限公司 | Alginic acid-chitosan composite fiber for tranma repairing and preparation method thereof |
| CN104069536A (en) * | 2014-07-11 | 2014-10-01 | 江苏开源康达医疗器械有限公司 | Method for preparing sodium alginate-chitosan nano-grade medical dressing |
| CN104069536B (en) * | 2014-07-11 | 2016-01-20 | 江苏开源康达医疗器械有限公司 | A kind of preparation method preparing sodium alginate-chitosan nanoscale medical dressing |
| CN106400191A (en) * | 2016-11-17 | 2017-02-15 | 无锡明盛纺织机械有限公司 | Composite fiber adopting skin-core type structure as well as preparation method and application of composite fiber |
| CN106835671A (en) * | 2016-12-22 | 2017-06-13 | 马鞍山市鑫程纳米新材料科技有限公司 | A kind of method for improving non-woven fabrics tensile strength |
| CN111434816A (en) * | 2019-01-15 | 2020-07-21 | 青岛大学 | Anti-raveling chitin fiber fabric and preparation method thereof |
| CN110241481A (en) * | 2019-05-28 | 2019-09-17 | 福建美可纸业有限公司 | A kind of superabsorbent water composite fibre and preparation method thereof |
| CN111020745A (en) * | 2019-12-31 | 2020-04-17 | 泰州市榕兴医疗用品股份有限公司 | Preparation method of sodium alginate and chitosan composite nanofiber |
| CN113648450A (en) * | 2021-08-11 | 2021-11-16 | 杭州仁世医疗器械有限公司 | Medical sterilization dressing and preparation method thereof |
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| CN1332081C (en) | 2007-08-15 |
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