CN1842520A - 1h-咪唑衍生物作为大麻素受体调节剂 - Google Patents
1h-咪唑衍生物作为大麻素受体调节剂 Download PDFInfo
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- CN1842520A CN1842520A CN 200480024349 CN200480024349A CN1842520A CN 1842520 A CN1842520 A CN 1842520A CN 200480024349 CN200480024349 CN 200480024349 CN 200480024349 A CN200480024349 A CN 200480024349A CN 1842520 A CN1842520 A CN 1842520A
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- Plural Heterocyclic Compounds (AREA)
Abstract
Description
化合物名称 | 以μg/ml表示的水溶解度 | |
pH=2 | pH=7 | |
N-环己基-1-(4-氯苯基)-2-(2,4-二氯苯基)-5-(吡咯烷-1-基甲基)-1H-咪唑-4-甲酰胺(化合物1) | >100 | 50 |
N-环己基-1-(4-氯苯基)-2-(2,4-二氯苯基)-5-(N,N-二甲基氨基甲基)-1H-咪唑-4-甲酰胺(化合物4) | >100 | 50 |
N-环己基-1-(4-氯苯基)-2-(2,4-二氯苯基)-1H-咪唑-4-甲酰胺(WO 03/063781) | 25 | 25 |
人大麻素CB1受体 | |
体外亲合力-pKi值 | |
化合物 | |
化合物1 | 8.1 |
化合物2 | 8.2 |
化合物3 | 7.0 |
化合物4 | 7.5 |
化合物5 | 6.3 |
化合物6 | 6.9 |
Claims (12)
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
EP03103867.2 | 2003-10-20 | ||
EP03103867 | 2003-10-20 |
Publications (2)
Publication Number | Publication Date |
---|---|
CN1842520A true CN1842520A (zh) | 2006-10-04 |
CN100556894C CN100556894C (zh) | 2009-11-04 |
Family
ID=34924117
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
CNB2004800243493A Expired - Fee Related CN100556894C (zh) | 2003-10-20 | 2004-10-19 | 作为大麻素受体调节剂的1h-咪唑衍生物 |
Country Status (7)
Country | Link |
---|---|
CN (1) | CN100556894C (zh) |
AR (1) | AR046182A1 (zh) |
HK (1) | HK1091823A1 (zh) |
SA (1) | SA04250339B1 (zh) |
TW (1) | TW200524908A (zh) |
UA (1) | UA82908C2 (zh) |
ZA (1) | ZA200603124B (zh) |
Cited By (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN101302200B (zh) * | 2007-05-09 | 2011-04-20 | 上海医药工业研究院 | 制备n-哌啶子基-5-(4-氯苯基)-1-(2,4-二氯苯基)-4-甲基吡唑-3-甲酰胺的方法 |
Family Cites Families (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
TWI231757B (en) * | 2001-09-21 | 2005-05-01 | Solvay Pharm Bv | 1H-Imidazole derivatives having CB1 agonistic, CB1 partial agonistic or CB1-antagonistic activity |
WO2003063781A2 (en) * | 2002-01-29 | 2003-08-07 | Merck & Co., Inc. | Substituted imidazoles as cannabinoid receptor modulators |
-
2004
- 2004-10-15 TW TW93131338A patent/TW200524908A/zh unknown
- 2004-10-15 AR ARP040103749 patent/AR046182A1/es not_active Application Discontinuation
- 2004-10-17 SA SA4250339A patent/SA04250339B1/ar unknown
- 2004-10-19 UA UAA200605398A patent/UA82908C2/uk unknown
- 2004-10-19 CN CNB2004800243493A patent/CN100556894C/zh not_active Expired - Fee Related
-
2006
- 2006-04-19 ZA ZA200603124A patent/ZA200603124B/en unknown
- 2006-11-09 HK HK06112346.0A patent/HK1091823A1/xx not_active IP Right Cessation
Cited By (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN101302200B (zh) * | 2007-05-09 | 2011-04-20 | 上海医药工业研究院 | 制备n-哌啶子基-5-(4-氯苯基)-1-(2,4-二氯苯基)-4-甲基吡唑-3-甲酰胺的方法 |
Also Published As
Publication number | Publication date |
---|---|
HK1091823A1 (en) | 2007-01-26 |
AR046182A1 (es) | 2005-11-30 |
TW200524908A (en) | 2005-08-01 |
ZA200603124B (en) | 2007-09-26 |
UA82908C2 (en) | 2008-05-26 |
CN100556894C (zh) | 2009-11-04 |
SA04250339B1 (ar) | 2008-07-19 |
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Correction item: Third inventor Correct: Van Stuivenberg Herman H. False: Stuivenberg Herman H. Number: 40 Volume: 22 |
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CI02 | Correction of invention patent application |
Correction item: Third inventor Correct: Van Stuivenberg Herman H. False: Stuivenberg Herman H. Number: 40 Page: The title page Volume: 22 |
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Free format text: CORRECT: THE THIRD INVENTOR; FROM: STUIVENBERG HERMAN H. TO: VAN STUIVENBERG HERMAN H. |
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Granted publication date: 20091104 Termination date: 20111019 |