CN1840169A - A Chinese medicinal composition and its application in relieving pain and skin itching - Google Patents
A Chinese medicinal composition and its application in relieving pain and skin itching Download PDFInfo
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Abstract
The invention provides a Chinese medicinal composition for treating aches and skin pruritus, which is prepared from 48 kinds of Chinese medicinal herbs including cicada shell, licorice root, capsule of weeping forsythia, selfheal, baikal skullcap root, futokadsura stem, cassia twig, isatic root, banksia rose, ledebouriella root, rose, pricklyash peel, fresh ginger, Ligusticum wallichii, honeysuckle flower, dahurian angelica root, dried rehmannia root, Schizonepeta tenuifolia, malt, lilyturf root, mulberry twigs, buck grass, safflower, dried orange peel, curculigo rhizome, mimosa-tree bark, honey-suckle stem, pubescent angelica root, atractylodes rhizome, basket fern, notopterygium root, radix paeoniae rubrathe, Chinese angelica root, poria cocos, siberian cocklebur fruit, loquat leaf, Bupleurum root, Chinese mugwort leafmulberry leaf, cnidium fruit, Chinese honey locust, greater celandine, root of herbaceous peony, mentha, boneol and campeachy wood.
Description
Technical field
The invention belongs to the field of Chinese medicines, relate to a kind of Chinese medicine composition that is used for the treatment of pain and pruritus.
Background technology
Pain is the key factor that influences health.The reason that causes pain is a lot, and its performance and trouble disease position are also inequality.At present, the medicine that is used for the treatment of pain is a lot, and Western medicine is mainly with anti-microbial type, corticosteroid hormone, vitamin, steroidal anti-inflammatory immunity, nonsteroidal anti-inflammatory analgetic etc.These medicines reach analgesic effect by directly pain cause being treated, and still, the side effect of these medicines is bigger, and analgesic effect is very indefinite yet, and life-time service can cause drug dependence.The medicine of treatment by Chinese herbs pain mainly contains oral administration pills (capsule and powder), unguentum (as SHANGSHI ZHITONG GAO) and spray, but it can not directly act on painful area, and analgesic effect is poor, and curative effect is slow.
Pruritus also is one of healthy factor of influence, treats the medicine of pruritus at present, mostly is hormone medicine, can not effect a radical cure focus, and side effect is strong, causes drug dependence easily.
Summary of the invention
Order of the present invention provides a kind of Chinese medicine composition for the treatment of pain and skin pruritus, and the treatment speed of this pharmaceutical composition is fast, the effect longer duration, have no side effect no drug dependence.
Theory of Chinese medical science is thought, " pain is then obstructed, and general rule is not bitterly ", based on this theory, treatment pain focuses on relaxing muscles and tendons to promote blood circulation, the detumescence dissipating blood stasis, and the collateral dredging that induces sweat is to reach the effect of wind-expelling pain-stopping.
Theory of Chinese medical science thinks that " itching " is relevant with " wind " or " wetting ", and also relevant with some chronic diseases such as diabetes, neurasthenia, menopathy, anemia, leukemia, nephropathy etc., obstinate disease causes body void, and " wind " is with " wet " evil intrusion skin and do " itching ".Should take determination of treatment based on pathogenesis obtained through differentiation of symptoms and signs to skin pruritus, treat, expelling wind and removing dampness antipruritic with dispelling wind, the skin moistening that nourishes blood is advisable, and plays the gas promoting the circulation of blood and transfers, damp eliminating is moisturized, and recovers and then itches pain from the effect that disappears.
Chinese medicine composition of the present invention is prepared from by following weight percentages:
Periostracum Cicadae 1-6 part Radix Glycyrrhizae 5-15 part Fructus Forsythiae 5-15 part Spica Prunellae 1-12 part
Volt Siberian cocklebur 5-15 part Caulis Piperis Kadsurae 5-15 part Ramulus Cinnamomi 1-12 part Radix Isatidis 1-12 part
Radix Aucklandiae 1-12 part Radix Saposhnikoviae 20-40 part Flos Rosae Rugosae 1-12 part Flos persicae 1-12 part
Pericarpium Zanthoxyli 5-25 part Rhizoma Zingiberis Recens 5-15 part Rhizoma Chuanxiong 10-30 part Flos Lonicerae 1-12 part
Radix Angelicae Dahuricae 5-20 part Radix Rehmanniae 1-6 part Herba Schizonepetae 5-15 part Fructus Hordei Germinatus 1-6 part
Radix Ophiopogonis 1-6 part Ramulus Mori 15-45 part Herba Lycopodii 15-45 part Flos Carthami 10-20 part
Pericarpium Citri Reticulatae 1-12 part Rhizoma Curculiginis 3-15 part Cortex Albiziae 1-12 part is born painful rattan 1-12 part
Radix Angelicae Pubescentis 15-40 part Rhizoma Atractylodis 10-30 part Rhizoma Osmundae 1-12 part Rhizoma Et Radix Notopterygii 10-30 part
Radix Paeoniae Rubra 1-10 part Radix Angelicae Sinensis 5-25 part Rhizoma Smilacis Glabrae 6-24 part Os Sepiae 1-6 part
Fructus Xanthii 1-6 part negative and positive are 5-15 part Folium Eriobotryae 5-20 part Radix Bupleuri 5-20 part suddenly
Folium Artemisiae Argyi 5-20 part Fructus Cnidii 5-20 part Fructus Gleditsia 10-40 part Herba Chelidonii 5-20 part
Radix Paeoniae Alba 5-20 part Herba Menthae 10-40 part Borneolum Syntheticum 10-40 part Lignum Sappan 5-20 part
Through a large amount of repetition tests, determined that finally the optimum weight proportioning of each raw material in the pharmaceutical composition of the present invention is:
10 parts of 6 parts of volts of 10 parts of Spica Prunellaes of 10 parts of Fructus Forsythiaes of 3 portions of Radix Glycyrrhizaes of Periostracum Cicadae Siberian cockleburs
30 parts of 6 parts of Radix Saposhnikoviaes of 6 parts of Radix Aucklandiae of 6 parts of Radix Isatidiss of 10 parts of Ramulus Cinnamomi of Caulis Piperis Kadsurae
15 parts of 10 parts of Rhizoma Chuanxiongs of 15 portions of Rhizoma Zingiberis Recenss of 6 portions of Pericarpium Zanthoxylies of 6 parts of Flos persicaes of Flos Rosae Rugosae
3 parts in 10 parts of Fructus Hordei Germinatus of 3 portions of Herba Schizonepetae of 12 parts of Radix Rehmanniae of 6 parts of Radixs Angelicae Dahuricae of Flos Lonicerae
6 parts of 15 parts of Pericarpium Citri Reticulataes of 30 parts of Flos Carthamis of 30 parts of Herba Lycopodiis of 3 parts of Ramulus Moris Radix Ophiopogonis
8 portions of Cortex Albiziaes of Rhizoma Curculiginis are born 20 parts of painful 25 parts of Rhizoma Atractylodis of 6 parts of Radix Angelicae Pubescentiss of rattan for 6 parts
12 parts of 15 parts of Rhizoma Smilacis Glabrae of 5 parts of Radix Angelicae Sinensis of 15 parts of Radix Paeoniae Rubra of 6 portions of Rhizoma Et Radix Notopterygiis of Rhizoma Osmundae
3 parts of negative and positive of 3 portions of Fructus Xanthii of Os Sepiae are 10 parts of 10 parts of Radix Bupleuri of 10 parts of Folium Eriobotryaes suddenly
10 parts of 10 portions of Radix Paeoniae Albas of 20 portions of Herba Chelidoniis of 10 parts of Fructus Gleditsia of 10 parts of Fructus Cnidiis of Folium Artemisiae Argyi
10 parts of 20 portions of Lignum Sappans of 20 parts of Borneolum Syntheticums of Herba Menthae.
Chinese medicine composition of the present invention can adopt adjuvant and preparation technology conventional on the Chinese materia medica to be prepared into any dosage form on the pharmaceutics.
Chinese medicine composition of the present invention can be prepared into decoction, liniment, spray or patch.
The function of Chinese medicine composition of the present invention
(1) in the effect aspect the treatment pain: can fully be proved by zoopery and clinical experiment.
One, zoopery
Control drug: dolantin injection.
Experimental apparatus: GJ-8401 mice hot plate dolorimeter.
Laboratory animal: white mice, body weight 21 ± 2g; New Zealand's large ear rabbit, body weight 2.5 ± 0.2kg.
Experimental technique:
1, analgesic activity
(1), to the influence of hot plate test: get 48 of female white mice, be divided into 3 groups at random; Each group gives normal saline, decoction medicine of the present invention and dolantin lumbar injection respectively; After the administration 30,60,90 and 120 minutes, measure 55 ℃ of hot plates of each treated animal input with stopwatch and rise, be i.e. the pain valve to the response time of licking metapedes; The result shows, analgesia antipruritic liquid of the present invention after administration 60 and 90min and administration before comparison there were significant differences, the results are shown in Table 1.
The influence of table 1 mice hot plate (
X+s, s)
| The group agent | Dosage ml | The pain valve | ||||
| Before the administration | 30min after the administration | 60min after the administration | 90min after the administration | 120min after the administration | ||
| Normal saline | 0.5 | 14.2±2.0 | 14.3±2.8 | 14.9±2.7 | 15.1±2.3 | 14.3±2.5 |
| Dolantin | 0.1 | 15.0±2.4 | 23.4±3.1 * | 25.0±3.1 ** | 22.8±2.3 | 16.8±2.9 |
| Analgesic solution | 0.5 | 14.5±2.1 | 16.1±2.7 | 20.3±2.9 * | 22.5±2.4 | 16.2±2.6 |
Annotate: with comparison before the administration
*P＜0.05;
*P＜0.01
(2), the influence of Dichlorodiphenyl Acetate writhing test: get 36 of mices, male and female half and half are divided into 3 groups at random; Each group gives normal saline, decoction medicine of the present invention and dolantin lumbar injection respectively; 60min after the administration, each group is injected 0.5% glacial acetic acid 0.2ml dragging pain respectively, writes down the writhing response number of mice in the 20min at interval behind the 5min respectively, and symptom shows as abdominal cavity indent, trunk and hind leg extension and buttocks and raises etc.The result shows that relatively there were significant differences for analgesia antipruritic liquid of the present invention and normal saline, relatively do not have significant difference with dolantin, the results are shown in Table 2.
The influence of table 2 pair mouse writhing reaction
| Group | Mice quantity | Dosage (ml) | Writhing response | Suppression ratio (%) |
| Normal saline | 12 | 0.5 | 47.18±3.80 | |
| Dolantin | 12 | 0.1 | 18.21±4.16 | 60.70 |
| Analgesic solution | 12 | 0.5 | 25.30±4.32 | 51.60 |
Annotate: compare with normal saline
*P＜0.01
2, toxicity
(1), determination of acute toxicity: get 40 of mices, male and female half and half; 24h irritates stomach for for 3 times every mice town decoction medicine of the present invention interior the branch, and each 0.8ml/, conventional breeding observing mice 24h does not see death or obvious toxicity occurs after the administration, shows that analgesia antipruritic liquid of the present invention has no side effect, and is safe and reliable.
(2), mucous membrane irritation is observed: get 12 of large ear rabbits, male and female half and half are divided into 2 groups at random.After each group gave decoction medicine of the present invention and liquid paraffin collunarium respectively, that every white rabbit nasal mucosa there is no was hemorrhage, edema and incrustation etc., showed that medicine of the present invention is very little to mucosa toxicity.
(3), rat dermal toxicity experiment:
10 of rat, body weight 180-230g tests the previous day at every rat back depilation 48cm
2Get wherein 5 and will press down painful antipruritic liquid and directly spread upon on the skin of depilation, smear once, smear continuously 6 times every half an hour.Get in addition 5 and scratch with needle point on the skin of depilation, hemorrhage (drawing well word cut) directly spreads upon the analgesia antipruritic liquid on the skin that scratches, observation rat skin contacts 24 hours with medicinal liquid after.5 skin colors of broken skin are abnormal, do not have abnormal phenomenas such as redness, erythema.There is slight red and swollen phenomenon at 5 skin cut places of scratching skin.Test and observed later in 10 days, 10 rat are movable normal, no pathological changes or death, and coating place skin is vivid, and the swelling has gone down at broken skin coating place removes, and forms a scab rat whole skin gloss, eyes and the no abnormal variation of nostril mucosa.
3, experimental result
Experiment shows: analgesia antipruritic liquid of the present invention can obviously improve mice hot plate pain valve, reduces the writhing response number of times of acetic-acid induced, and rat depilation coating place physiology is normal, and no obvious toxicity can be for clinical use.Simultaneously show that also this medicine is a liquid preparation, should not smear that health also should not carry out the whole body decoction and bathe treatment if broken skin wound is arranged in the wound of broken skin.
Two, clinical trial
1, to the treatment situation of arthralgia, the pain over the chest and back, pain of the nape, extremity pain.
Case is selected: to joint, thoracic dorsal, neck and extremity pain patient clinical observation 200 examples, be divided into treatment group and matched group at random in 3: 1 ratios.150 examples are organized in treatment, pain degree: mild pain 36 examples, moderate pain 81 examples, severe pain 33 examples; Matched group is observed 50 examples altogether, pain degree: mild pain 12 examples, moderate pain 23 examples, severe pain 15 examples.The treatment group is used decoction medicine of the present invention.
Therapeutic Method: the treatment group is used decoction medicine of the present invention.Usage and consumption: mild pain is got decoction medicine 50ml of the present invention, and balneation was soaked 30 minutes in the adding 100kg warm water; Moderate pain is got decoction medicine 60ml of the present invention, and balneation was soaked 60 minutes in the adding 100kg warm water; Severe pain is got decoction medicine 80ml of the present invention, and balneation was soaked 90 minutes in the adding 100kg warm water.For keeping bathing soup constant temperature, use the electric heater that possesses earth leakage protective device and temperature automatically controlled adjusting device in the immersion process.Matched group uses ibuprofen, usage and consumption: mild pain oral 1 (60mg), 2 times/day; Oral 2 of moderate pain, 2 times/day; Oral 2 of severe pain, 2 times/day.
Observe that the treatment situation sees Table 3, table 4, table 5.
The situation that begins to extenuate before and after table 3 joint, thoracic dorsal, neck and extremity pain treatment group and the matched group medication:
| Group | The example number | Pain begins remission time (min) | Do not take effect | Total effective rate (%) | ||||
| 1-3 | 4-8 | 9-12 | 13-19 | More than 19 | ||||
| Control group | 150 | 48(32) ** | 48(32) ** | 20 (13.33) | 18 (12.00) | 14 (9.33) | 2(1.33) | 148 (98.66) |
| Matched group | 50 | 0 | 0 | 8(16) | 12(24) | 14(28) | 16(32) | 34(68.00) |
Annotate: compare with matched group
*P＜0.005
Situation is kept in pain relief after table 4 neck, thoracic dorsal, joint and extremity pain treatment group and the matched group medication:
| Group | The example number | Pain relief hold time (h) | Do not take effect | Total effective rate (%) | ||||
| 1-3 | 4-8 | 9-12 | 13-19 | More than 19 | ||||
| Control group | 150 | 26(17.33) | 57(38.00) | 42(28.0) | 15(10.00) | 7(4.66) | 3(2.00) | 147(98.00) |
| Matched group | 50 | 6(8.3) | 21(42.0) | 6(8.3) | 2(4.0) | 0 | 16(32.0) | 34(68.00) |
Annotate: compare with matched group,
*＜0.005
Pain relieving situation after table 5 neck, thoracic dorsal, joint and limbs pain treatment group and the matched group medication
| Group | The example number | The pain relieving result | Total effective rate (%) | |||
| Alleviate fully | Part is alleviated | The slight alleviation | Do not have and alleviate | |||
| Control group | 150 | 82(54,66) | 34(22,66) | 32(21.33) | 2(1.33) | 148(98.00) |
| Matched group | 50 | 8(16,00) | 18(36,00) | 8(16.00) | 16(32.00) | 34(68.00) |
2, to the treatment situation of neuropathic pain:
Case is selected: clinical observation 82 examples are divided into treatment group and matched group at random.The treatment group is observed case 62 examples, wherein, and mild pain 17 examples, moderate pain 34 examples, severe pain 11 examples.Matched group is observed case 20 examples, wherein, and mild pain 4 examples, moderate pain 12 examples, severe pain 5 examples.
Therapeutic Method: the treatment group is used decoction medicine of the present invention.Usage and consumption: mild pain is got decoction medicine 50ml of the present invention, and balneation was soaked 30 minutes in the adding 100kg warm water; Moderate pain is got decoction medicine 60ml of the present invention, and balneation was soaked 60 minutes in the adding 100kg warm water; Severe pain is got decoction medicine 60ml of the present invention, and balneation was soaked 60 minutes in the adding 100kg warm water.Matched group uses BILITONG, and each oral 1,3 times/day; Vitamin B
1Each oral 20mg, 3 times/day.The treatment situation of observing two groups of neuralgia patients sees Table 6, table 7, table 8, table 9.
Table 6 neuralgia treatment group and matched group case situation:
| The treatment group | The example number | Matched group | The example number |
| Trigeminal neuralgia | 8 | Trigeminal neuralgia | 2 |
| Sciatica | 14 | Sciatica | 5 |
| Saphenous neuralgia | 15 | Saphenous neuralgia | 3 |
| Superior clunial nerves | 12 | Superior clunial nerves | 4 |
| Clunis inside neuralgia | 13 | Clunis inside neuralgia | 6 |
| Add up to | 62 | 20 |
Pain begins the alleviation situation after table 7 neuralgia treatment group and the matched group medication: (min) %
| Group | The example number | 1-3 | 4-7 | 8-10 | 11-30 | Invalid more than 30 | Effective percentage (%) |
| Smelting treatment group | 62 | 18(29.03) | 26(41.93) | 9(14.51) | 5(8.06) | 4(6.45) | 58(93.53) |
| Matched group | 20 | 0(0.00) | 0(0.00) | 8(40.00) | 5(25.00) | 7(35.00) | 13(65.00) |
Annotate: with compare,
*P＜0.005.
Situation is kept in pain relief after table 8 neuralgia treatment group and the matched group medication: (h) %
| Group | The example number | 1-3 | 4-7 | 8-10 | More than 11 | Invalid | Total effective rate (%) |
| The treatment group | 62 | 16(25.80) | 14(22.58) | 18(29.03) | 18(29.03) | 4(6.45) | 58(93.53) ** |
| Matched group | 20 | 8(40.00) | 3(15.00) | 0(0.00) | 0(00.00) | 9(45.00) | 11(55.00) |
Annotate: compare with matched group,
*P＜0.005.
Pain relieving situation after table 9 neuralgia treatment group and the matched group medication:
| Group | The example number | Alleviate fully | Part is alleviated | The slight alleviation | Do not have and alleviate | Total remission rate % |
| Smelting treatment group | 62 | 36(58.06) | 18(29.03) | 5(8.06) | 3(4.83) | 59(95.15) |
| Matched group | 20 | 2(15.00) | 8(40.00) | 2(10.00) | 7(35.00) | 13(65.00) |
3, to internal organs treatment of pain situation:
Case is selected: 70 examples are observed in the visceral pain treatment, are divided into treatment group and matched group at random.40 examples are organized in treatment.Mild pain 12 examples wherein, moderate pain 23 examples, severe pain 5 examples; Matched group 30 examples, mild pain 15 examples wherein, moderate pain 11 examples, severe pain 4 examples.The treatment group is used decoction medicine of the present invention, usage and consumption; Mild pain is got decoction medicine 60ml of the present invention, dissolves in the 100kg warm water, and balneation was soaked 60 minutes; Moderate pain is got analgesia antipruritic liquid 80ml, dissolves in the 100kg warm water, and balneation was soaked 60 minutes; Severe pain is got analgesic solution 80ml, dissolves in the 100kg warm water, and balneation was soaked 60 minutes.Matched group racemization henbane alkali sheet, usage and consumption: mild pain oral 1 (5mg), oral 2 of moderate pain, oral 3 of severe pain 3 times/day, is observed the treatment situation and is seen (table 10, table 11, table 12).
The situation that pain begins to extenuate after table 10 Encelialgia treatment group and the matched group medication:
| Group | The example number | Pain begins remission time (min) | Invalid more than 300 | Total effective rate (%) | ||||
| 1-3 | 4-7 | 8-10 | 11-20 | More than 20 | ||||
| The treatment group | 40 | 7(17.50) * | 15(37.50) ** | 7(17.50) | 3(7.50) | 2(5.00) | 2(5.00) | 38(95.00) ** |
| Matched group | 30 | 0 | 0 | 5(16.66) | 8(26.66) | 4(13.33) | 9(30.00) | 21(70.00) |
Annotate: compare with matched group
*P＜0.05,
*P＜0.005
Situation is kept in pain relief after table 11 Encelialgia treatment group and the matched group medication:
| Group | The example number | Pain relief hold time (h) | Invalid (%) | Total effective rate (%) | ||||
| 1-3 | 4-7 | 8-10 | 11-20 | More than 20 | ||||
| The treatment group | 40 | 5(12.50) | 20(37.50) * | 8(20.00) | 2(5.00) | 3(7.50) | 2(5.00) | 38(95.00) * |
| Matched group | 30 | 9(30.00) | 7(23.33) | 4(13.33) | 1(3.00) | 0 | 9(30.00) | 21(70.00) |
Pain relieving situation after table 12 Encelialgia treatment group and the matched group medication
| Group | The example number | Alleviate fully | Part is alleviated | The slight alleviation | Do not have and alleviate | Total remission rate % |
| Smelting treatment group | 40 | 30(75.00) | 5(12.50) * | 3(7.50) | 2(5.00) | 38(85.00) * |
| Matched group | 30 | 8(26.66) | 11(36.66) | 2(6.66) | 9(30.00) | 21(70.00) |
Annotate: compare with matched group
*P＜0.05,
*P＜0.005
Three, conclusion
Above-mentioned zoopery and clinical trial show: medicine of the present invention is being treated the equal notable therapeutic effect of arthralgia, the pain over the chest and back, pain of the nape, extremity pain, neuropathic pain and visceral pain.
(2) in the function aspect the treatment skin pruritus: can fully be proved by clinical experiment.
1, case is selected: skin pruritus is observed treatment 150 examples, is divided into treatment group and matched group at random.100 examples are organized in treatment, its mild or moderate pruritus 40 examples, moderate pruritus 48 examples, severe pruritus 12 examples.Matched group 50 examples, its mild or moderate pruritus 28 examples, moderate pruritus 16 examples, severe pruritus 6 examples.
2, Therapeutic Method: the treatment group is used decoction medicine of the present invention, usage and consumption: slight pruritus is got decoction medicine 50ml of the present invention, adds 100kg warm water and stirs.Balneation was soaked 60 minutes; The moderate pruritus is got decoction medicine 60ml of the present invention, adds in the 100kg warm water, and balneation was soaked 90 minutes; The severe pruritus is got decoction medicine 60ml of the present invention, adds in the 100kg warm water, and balneation was soaked 90 minutes.Matched group is treated with hismanal, usage and consumption: oral 1 of slight pruritus, oral 2 of moderate pruritus, oral 2 of severe pruritus, 1 time/day.Observe treatment pruritus situation and see (table 13, table 14, table 15, table 16).
Table 13 skin pruritus treatment group and matched group case situation:
| The treatment group | The example number | Matched group | The example number |
| Psoriasis | 10 | Psoriasis | 3 |
| Eczema | 6 | Eczema | 2 |
| Urticaria | 6 | Urticaria | 1 |
| Scabies | 3 | Scabies | 2 |
| Scleroderma | 2 | Scleroderma | 1 |
| Folliculitis | 17 | Folliculitis | 9 |
| Contact dermatitis | 21 | Contact dermatitis | 11 |
| Herpes zoster | 8 | Herpes zoster | 4 |
| Lichen planus | 4 | Lichen planus | 2 |
| Neurodermatitis | 2 | Neurodermatitis | 1 |
| Seborrheic dermatitis | 3 | Seborrheic dermatitis | 1 |
| Vitamin B1 deficiency | 12 | Vitamin B1 deficiency | 10 |
| Colpitis mycotica | 6 | Colpitis mycotica | 3 |
| Add up to | 100 | 50 |
The situation that pruritus begins to extenuate after table 14 skin pruritus treatment group and the matched group medication:
| Group | The example number | Pain begins remission time (min) | Invalid (%) | Total effective rate (%) | ||||
| 1-3 | 4-7 | 8-11 | 12-20 | More than 20 | ||||
| The treatment group | 100 | 12(12.00) | 46(46.00) | 23(23.00) | 14(14.00) | 6(6.00) | 2(2.00) | 98(98.00) |
| Matched group | 50 | 0 | 0 | 8(16.00) | 21(42.00) | 2(4.00) | 19(38.00) | 31(12.00) |
Pruritus is extenuated the situation of keeping after table 15 skin pruritus treatment group and the matched group medication:
| Group | The example number | Pruritus is alleviated the situation of keeping | Invalid (%) | Total effective rate (%) | ||||
| 1-3 | 4-7 | 8-11 | 11-20 | More than 20 | ||||
| The treatment group | 100 | 15(15.00) | 40(40.00) | 32(32.00) | 8(8.00) | 3(3.00) | 2(2.00) | 98(98.00) |
| Matched group | 50 | 8(16.00) | 6(12.00) | 5(10.00) | 5(10.00) | 5(10.00) | 21(42.00) | 29(58.00) |
Antipruritic situation after table 16 skin pruritus treatment group and the matched group medication:
| Group | The example number | Antipruritic result | Total effective rate % | |||
| Extenuate fully | Part is extenuated | Slightly extenuate | Nothing is extenuated | |||
| The treatment group | 100 | 53(53.00) | 29(29.00) | 15(15.00) | 3(3.00) | 97(97.00) |
| Matched group | 50 | 4(8.00) | 17(34.00) | 13(26.00) | 16(32.00) | 34(68.00) |
3, conclusion
Chinese medicine composition of the present invention has significant therapeutic effect to skin pruritus.
(3) the present invention is to the experiment of human body health care and skin Caring
1, experimental subject: this experiment is on the basis of animal toxicology experiment, and the trier reaches more than 500 people.Its using method one is that decoction is bathed; The 2nd, perfrication.Decoction is bathed and is got in the decoction medicine 50ml adding 100kg warm water of the present invention, and balneation was soaked 30 minutes, 1 time/day; Perfrication is poured medicinal liquid 10ml into the palm of the hand, directly medicinal liquid is embrocated in face with the method that washes one's face, or is being embrocated on the face with the continuous dip in liquid medicine of signing, and water cleans after 20 minutes, 1 time/day.Therefrom select 100 examples and be experimental group.Male's 20 examples wherein, women's 80 examples; 18 years old of age minimum, maximum 60 years old, The median age 39 years old; Adopt soup to bathe 61 examples of method, iatraliptic 39 examples.Matched group is totally 50 examples.The salt soup of wherein suckling is bathed, beauty mask 14 examples.
2, the evaluation standard of experiment effect:
Decoction is bathed: the health tired disappearance of aching, human body is glossy, smooth, fine and smooth.
Face is embrocated: skin ruddy glossy, spot alleviates, canthus wrinkle reduces.
Experimental result: see Table 17, table 18
Table 17 soup bath method health care skin Caring experimental group with the time according to the comparison of group effect:
| Group | The example number | The time (greatly) that positive effect occurs | Invalid % | Total effective rate % | ||||
| 1-3 | 4-7 | 8-11 | 12-30 | More than 20 | ||||
| Experimental group | 100 | 10(10.00) | 16(16.00) | 28(38.00) | 41(41.00) | 3(3.00) | 2(2.00) | 98(98.00) |
| Matched group | 50 | 0 | 8(16.00) | 21(42.00) | 10(20.00) | 6(12.00) | 5(10.00) | 45(90.00) |
Effect is relatively after facial perfrication experimental group of table 18 and the matched group medication:
| Group | The example number | The time of appearance positive effect (my god) | Invalid % | Total effective rate % | ||||
| 1-3 | 4-7 | 8-11 | 12-30 | More than 20 | ||||
| Experimental group | 100 | 14(14.00) | 21(21.00) | 52(52.00) | 8(8.00) | 5(5.00) | 0 | 100(100.00) |
| Matched group | 50 | 8(16.00) | 10(20.00) | 17(34.00) | 9(18.00) | 3(6.00) | 3(6.00) | 47(94.00) |
Above-mentioned zoopery and clinical trial prove, the present invention's antipruritic liquid that eases pain has following characteristics:
1, the present invention treats pain and pruritus is effective, antalgesic-antipruritic speed is fast, antalgesic-antipruritic effect longer duration.
2, the present invention is a pure Chinese medicinal preparation, and nontoxic secondary work, no medicine are according to lazyness.
3, the present invention has used for reference traditional dipping method in ancient times on the usage of medicine.Human body steams under the bubble at lukewarm water, and pore is expanded rapidly, and medicine soaks in the body by skin, activates neurocyte, accelerates blood circulation, enhances metabolism, and eliminates the lump and stasis of blood knot, thereby reaches the pain relieving purpose.Aspect the treatment skin pruritus, take the warm water dilute liquid medicine directly to soak the method in affected part, kill epidermis antibacterial and fungus, simultaneously, medicinal liquid sees through skin and acts on cells in vivo, Shujin, invigorate blood circulation, collateral dredging, repairing skin tissue, treating both the principal and secondary aspects of a disease is realized the itching relieving purpose.
4, applied range of the present invention, the treatment of the skin pruritus that causes to the treatment of the treatment of neuralgia and neck, thoracic dorsal, joint, limbs pain with to microbial bacterial, mycete, fungus etc. has tangible effect.Can be used for Chinese medicine soup when not having slight illness and bathe and bathe the foot health care, can play allaying tiredness, the effect of skin care, skin Caring.
The specific embodiment
Embodiment 1, soup of the present invention are bathed the preparation of agent: liniment, spray or patch
Prescription: (in weight ratio part)
10 parts of 6 parts of volts of 10 parts of Spica Prunellaes of 10 parts of Fructus Forsythiaes of 3 portions of Radix Glycyrrhizaes of Periostracum Cicadae Siberian cockleburs
30 parts of 6 parts of Radix Saposhnikoviaes of 6 parts of Radix Aucklandiae of 6 parts of Radix Isatidiss of 10 parts of Ramulus Cinnamomi of Caulis Piperis Kadsurae
15 parts of 10 parts of Rhizoma Chuanxiongs of 15 portions of Rhizoma Zingiberis Recenss of 6 portions of Pericarpium Zanthoxylies of 6 parts of Flos persicaes of Flos Rosae Rugosae
3 parts in 10 parts of Fructus Hordei Germinatus of 3 portions of Herba Schizonepetae of 12 parts of Radix Rehmanniae of 6 parts of Radixs Angelicae Dahuricae of Flos Lonicerae
6 parts of 15 parts of Pericarpium Citri Reticulataes of 30 parts of Flos Carthamis of 30 parts of Herba Lycopodiis of 3 parts of Ramulus Moris Radix Ophiopogonis
8 portions of Cortex Albiziaes of Rhizoma Curculiginis are born 20 parts of painful 25 parts of Rhizoma Atractylodis of 6 parts of Radix Angelicae Pubescentiss of rattan for 6 parts
12 parts of 15 parts of Rhizoma Smilacis Glabrae of 5 parts of Radix Angelicae Sinensis of 15 parts of Radix Paeoniae Rubra of 6 portions of Rhizoma Et Radix Notopterygiis of Rhizoma Osmundae
3 parts of negative and positive of 3 portions of Fructus Xanthii of Os Sepiae are 10 parts of 10 parts of Radix Bupleuri of 10 parts of Folium Eriobotryaes suddenly
10 parts of 10 portions of Radix Paeoniae Albas of 20 portions of Herba Chelidoniis of 10 parts of Fructus Gleditsia of 10 parts of Fructus Cnidiis of Folium Artemisiae Argyi
10 parts of 20 portions of Lignum Sappans of 20 parts of Borneolum Syntheticums of Herba Menthae.
Technology:
1, each herbal medicine in the above-mentioned prescription is pulverized;
2, with the Radix Glycyrrhizae in the above-mentioned prescription, Fructus Forsythiae, Caulis Piperis Kadsurae, Spica Prunellae, Fu Ling, the Radix Aucklandiae, Ramulus Cinnamomi, Radix Isatidis, Lignum Sappan, Radix Saposhnikoviae, Pericarpium Zanthoxyli, Rhizoma Zingiberis Recens, Rhizoma Chuanxiong, the Radix Angelicae Dahuricae, the Radix Rehmanniae, Herba Schizonepetae, Ramulus Mori, Herba Lycopodii, Pericarpium Citri Reticulatae, Rhizoma Curculiginis, Cortex Albiziae, Caulis Lonicerae, Radix Angelicae Pubescentis, Rhizoma Atractylodis, Rhizoma Osmundae, Rhizoma Et Radix Notopterygii, Radix Paeoniae Rubra, Radix Angelicae Sinensis, Rhizoma Smilacis Glabrae, Os Sepiae, Fructus Xanthii, Folium Eriobotryae, Radix Bupleuri, Folium Artemisiae Argyi, Fructus Cnidii, Fructus Gleditsia, Herba Chelidonii, the Radix Paeoniae Alba, after the powder mixes of Herba Menthae 39 flavor medicines, put into wooden barrel and add 3-5 times of cold water immersion 8 hours, medicine is poured in the rustless steel extraction pot together with the cold water of soak medicine, slow fire boiling 40 minutes is filtered.Filtrate is concentrated, doubly measure 95% ethanol precipitation 8-12 hour with 2-5, it is standby to get supernatant.
3, with the Periostracum Cicadae in the above-mentioned prescription, Flos Rosae Rugosae, Flos persicae, Flos Lonicerae, Fructus Hordei Germinatus, Radix Ophiopogonis, Flos Carthami, negative and positive suddenly 8 flavor medicines put into wooden barrel and add 2-3 times of cold water and soaked 2 hours, poured in the rustless steel extraction pot medicine into slow fire boiling 30 minutes together with soaking water, filter.Filtrate take out is concentrated, doubly measure 95% ethanol precipitation 8-12 hour with 2-5, it is standby to get supernatant.
4, after the supernatant mixing that step 2,3 is extracted, add Borneolum Syntheticum and stir, add the heavy clear agent of 101 fruit juice again and staticly settle, disgorging is divided in the plastic bottle through after the sterilization treatment, is soup and bathes agent.
Using method: elder generation puts into warm water in bathtub, medicinal liquid is poured in the warm water to stir evenly again, and balneation is soaked 30-90 minute (when water is cool, in time heat with special electric heater, keep temperature), dosage can be regulated with disease weight plus-minus, and consumption: warm water 100kg adds medicinal liquid 50-100ml.
The preparation of embodiment 2, spray of the present invention
Prescription (in weight portion):
5 parts of 1 part of volt of 5 parts of Spica Prunellaes of 5 parts of Fructus Forsythiaes of 1 portion of Radix Glycyrrhizae of Periostracum Cicadae Siberian cockleburs
20 parts of 1 part of Radix Saposhnikoviaes of 1 part of Radix Aucklandiae of 1 part of Radix Isatidis of 5 parts of Ramulus Cinnamomi of Caulis Piperis Kadsurae
10 parts of 5 parts of Rhizoma Chuanxiongs of 5 portions of Rhizoma Zingiberis Recenss of 1 portion of Pericarpium Zanthoxyli of 1 part of Flos persicae of Flos Rosae Rugosae
6 parts in 15 parts of Fructus Hordei Germinatus of 6 portions of Herba Schizonepetae of 20 parts of Radix Rehmanniae of 1 part of Radix Angelicae Dahuricae of Flos Lonicerae
12 parts of 20 parts of Pericarpium Citri Reticulataes of 45 parts of Flos Carthamis of 45 parts of Herba Lycopodiis of 6 parts of Ramulus Moris Radix Ophiopogonis
15 portions of Cortex Albiziaes of Rhizoma Curculiginis are born 30 parts of painful 40 parts of Rhizoma Atractylodis of 12 parts of Radix Angelicae Pubescentiss of rattan for 12 parts
15 parts of 15 parts of Rhizoma Smilacis Glabrae of 12 portions of Rhizoma Et Radix Notopterygiis of Rhizoma Osmundae 10-30,5 parts of Radix Angelicae Sinensis of part Radix Paeoniae Rubra
3 parts of negative and positive of 3 portions of Fructus Xanthii of Os Sepiae are 13 parts of 12 parts of Radix Bupleuri of 10 parts of Folium Eriobotryaes suddenly
14 parts of 15 portions of Radix Paeoniae Albas of 25 portions of Herba Chelidoniis of 12 parts of Fructus Gleditsia of 15 parts of Fructus Cnidiis of Folium Artemisiae Argyi
15 parts of 20 portions of Lignum Sappans of 25 parts of Borneolum Syntheticums of Herba Menthae
Technology: identical with embodiment 1, different is is divided in the medicinal liquid after doing in the bottle of band shower nozzle promptly.
Using method: during use, nozzle alignment pain and pruritus position are sprayed at the affected part with medicinal liquid, and visual disease weight sprays 2-5 time continuously.
The preparation of embodiment 3, patch of the present invention
Prescription (in weight portion):
12 parts of 15 parts of Spica Prunellaes of 15 parts of Fructus Forsythiaes of 6 portions of Radix Glycyrrhizaes of Periostracum Cicadae
12 parts of 12 parts of Radix Isatidiss of volt 15 parts of Ramulus Cinnamomi of 15 portions of Caulis Piperis Kadsuraes of Siberian cocklebur
12 parts in 12 parts of Flos persicaes of 40 portions of Flos Rosae Rugosaes of 12 parts of Radix Saposhnikoviaes of the Radix Aucklandiae
12 parts of 30 portions of Flos Loniceraes of 15 parts of Rhizoma Chuanxiongs of 25 portions of Rhizoma Zingiberis Recenss of Pericarpium Zanthoxyli
1 part in 5 parts of Fructus Hordei Germinatus of 1 portion of Herba Schizonepetae of 5 parts of Radix Rehmanniae of the Radix Angelicae Dahuricae
10 parts on 15 parts of Flos Carthamis of 15 parts of Herba Lycopodiis of 1 part of Ramulus Mori Radix Ophiopogonis
3 portions of Cortex Albiziaes of 1 portion of Rhizoma Curculiginis of Pericarpium Citri Reticulatae are born 1 part in painful rattan for 1 part
10 parts of 1 portion of Rhizoma Et Radix Notopterygiis of 10 parts of Rhizoma Osmundae of 15 parts of Rhizoma Atractylodis of Radix Angelicae Pubescentis
3 parts of 12 parts of Os Sepiae of 15 parts of Rhizoma Smilacis Glabrae of 6 parts of Radix Angelicae Sinensis of Radix Paeoniae Rubra
3 parts of negative and positive of Fructus Xanthii are 13 parts of 12 parts of Radix Bupleuri of 10 parts of Folium Eriobotryaes suddenly
14 parts of 24 portions of Herba Chelidoniis of 15 parts of Fructus Gleditsia of 15 parts of Fructus Cnidiis of Folium Artemisiae Argyi
15 parts of 25 portions of Lignum Sappans of 20 parts of Borneolum Syntheticums of 12 portions of Herba Menthaes of the Radix Paeoniae Alba
Technology: identical with embodiment 1, different must be that the last medicinal liquid that will prepare adopts the conventional adjuvant and the preparation technology of patch to be prepared into paster.
Using method: paster is affixed on painful area gets final product.
The preparation of embodiment 4, liniment of the present invention
Prescription (in weight portion):
6 parts of 10 parts of Spica Prunellaes of 10 parts of Fructus Forsythiaes of 3 portions of Radix Glycyrrhizaes of Periostracum Cicadae
6 parts of 6 parts of Radix Isatidiss of volt 10 parts of Ramulus Cinnamomi of 10 portions of Caulis Piperis Kadsuraes of Siberian cocklebur
6 parts in 6 parts of Flos persicaes of 30 portions of Flos Rosae Rugosaes of 6 parts of Radix Saposhnikoviaes of the Radix Aucklandiae
6 parts of 20 portions of Flos Loniceraes of 10 parts of Rhizoma Chuanxiongs of 14 portions of Rhizoma Zingiberis Recenss of Pericarpium Zanthoxyli
1 part in 5 parts of Fructus Hordei Germinatus of 1 portion of Herba Schizonepetae of 5 parts of Radix Rehmanniae of the Radix Angelicae Dahuricae
10 parts on 15 parts of Flos Carthamis of 15 parts of Herba Lycopodiis of 1 part of Ramulus Mori Radix Ophiopogonis
3 portions of Cortex Albiziaes of 1 portion of Rhizoma Curculiginis of Pericarpium Citri Reticulatae are born 1 part in painful rattan for 1 part
10 parts of 1 portion of Rhizoma Et Radix Notopterygiis of 10 parts of Rhizoma Osmundae of 15 parts of Rhizoma Atractylodis of Radix Angelicae Pubescentis
6 parts of 24 parts of Os Sepiae of 25 parts of Rhizoma Smilacis Glabrae of 10 parts of Radix Angelicae Sinensis of Radix Paeoniae Rubra
6 parts of negative and positive of Fructus Xanthii are 20 parts of 20 parts of Radix Bupleuri of 15 parts of Folium Eriobotryaes suddenly
20 parts of 40 portions of Herba Chelidoniis of 20 parts of Fructus Gleditsia of 20 parts of Fructus Cnidiis of Folium Artemisiae Argyi
20 parts of 40 portions of Lignum Sappans of 40 parts of Borneolum Syntheticums of 20 portions of Herba Menthaes of the Radix Paeoniae Alba
Technology: same with embodiment 1, be divided in the plastic bottle through after the sterilization treatment.
Using method: open bottle cap, medicinal liquid is dipped on cotton swab embrocate in pain and pruritus place.
Claims (10)
1, a kind of Chinese medicine composition is formed by the feedstock production of following weight than part:
Periostracum Cicadae 1-6 part Radix Glycyrrhizae 5-15 part Fructus Forsythiae 5-15 part Spica Prunellae 1-12 part
Volt Siberian cocklebur 5-15 part Caulis Piperis Kadsurae 5-15 part Ramulus Cinnamomi 1-12 part Radix Isatidis 1-12 part
Radix Aucklandiae 1-12 part Radix Saposhnikoviae 20-40 part Flos Rosae Rugosae 1-12 part Flos persicae 1-12 part
Pericarpium Zanthoxyli 5-25 part Rhizoma Zingiberis Recens 5-15 part Rhizoma Chuanxiong 10-30 part Flos Lonicerae 1-12 part
Radix Angelicae Dahuricae 5-20 part Radix Rehmanniae 1-6 part Herba Schizonepetae 5-15 part Fructus Hordei Germinatus 1-6 part
Radix Ophiopogonis 1-6 part Ramulus Mori 15-45 part Herba Lycopodii 15-45 part Flos Carthami 10-20 part
Pericarpium Citri Reticulatae 1-12 part Rhizoma Curculiginis 3-15 part Cortex Albiziae 1-12 part is born painful rattan 1-12 part
Radix Angelicae Pubescentis 15-40 part Rhizoma Atractylodis 10-30 part Rhizoma Osmundae 1-12 part Rhizoma Et Radix Notopterygii 10-30 part
Radix Paeoniae Rubra 1-10 part Radix Angelicae Sinensis 5-25 part Rhizoma Smilacis Glabrae 6-24 part Os Sepiae 1-6 part
Fructus Xanthii 1-6 part negative and positive are 5-15 part Folium Eriobotryae 5-20 part Radix Bupleuri 5-20 part suddenly
Folium Artemisiae Argyi 5-20 part Fructus Cnidii 5-20 part Fructus Gleditsia 10-40 part Herba Chelidonii 5-20 part
Radix Paeoniae Alba 5-20 part Herba Menthae 10-40 part Borneolum Syntheticum 10-40 part Lignum Sappan 5-20 part.
2, as claims 1 described Chinese medicine composition, it is characterized in that: form by the feedstock production of following weight than part:
10 parts of 6 parts of volts of 10 parts of Spica Prunellaes of 10 parts of Fructus Forsythiaes of 3 portions of Radix Glycyrrhizaes of Periostracum Cicadae Siberian cockleburs
30 parts of 6 parts of Radix Saposhnikoviaes of 6 parts of Radix Aucklandiae of 6 parts of Radix Isatidiss of 10 parts of Ramulus Cinnamomi of Caulis Piperis Kadsurae
15 parts of 10 parts of Rhizoma Chuanxiongs of 15 portions of Rhizoma Zingiberis Recenss of 6 portions of Pericarpium Zanthoxylies of 6 parts of Flos persicaes of Flos Rosae Rugosae
3 parts in 10 parts of Fructus Hordei Germinatus of 3 portions of Herba Schizonepetae of 12 parts of Radix Rehmanniae of 6 parts of Radixs Angelicae Dahuricae of Flos Lonicerae
6 parts of 15 parts of Pericarpium Citri Reticulataes of 30 parts of Flos Carthamis of 30 parts of Herba Lycopodiis of 3 parts of Ramulus Moris Radix Ophiopogonis
8 portions of Cortex Albiziaes of Rhizoma Curculiginis are born 20 parts of painful 25 parts of Rhizoma Atractylodis of 6 parts of Radix Angelicae Pubescentiss of rattan for 6 parts
12 parts of 15 parts of Rhizoma Smilacis Glabrae of 5 parts of Radix Angelicae Sinensis of 15 parts of Radix Paeoniae Rubra of 6 portions of Rhizoma Et Radix Notopterygiis of Rhizoma Osmundae
3 parts of negative and positive of 3 portions of Fructus Xanthii of Os Sepiae are 10 parts of 10 parts of Radix Bupleuri of 10 parts of Folium Eriobotryaes suddenly
10 parts of 10 portions of Radix Paeoniae Albas of 20 portions of Herba Chelidoniis of 10 parts of Fructus Gleditsia of 10 parts of Fructus Cnidiis of Folium Artemisiae Argyi
10 parts of 20 portions of Lignum Sappans of 20 parts of Borneolum Syntheticums of Herba Menthae.
3, Chinese medicine composition as claimed in claim 1 is characterized in that: adopt adjuvant and preparation technology conventional on the Chinese materia medica to be prepared into any dosage form on the pharmaceutics.
4, Chinese medicine composition as claimed in claim 1 is characterized in that: its dosage form is decoction, liniment, spray or patch.
5, Chinese medicine composition as claimed in claim 1 is used for the treatment of pain.
6, Chinese medicine composition as claimed in claim 5 is characterized in that: be used for the treatment of arthralgia, the pain over the chest and back, extremity pain, pain of the nape.
7, Chinese medicine composition as claimed in claim 5 is characterized in that: be used for the treatment of neuralgia.
8, Chinese medicine composition as claimed in claim 5 is characterized in that: be used for the treatment of Encelialgia.
9, Chinese medicine composition as claimed in claim 1 is characterized in that: be used for the treatment of skin pruritus.
10, Chinese medicine composition as claimed in claim 1 is characterized in that: be used for skin care.
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| CNA2006100416807A CN1840169A (en) | 2006-01-12 | 2006-01-12 | A Chinese medicinal composition and its application in relieving pain and skin itching |
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| CNA2006100416807A CN1840169A (en) | 2006-01-12 | 2006-01-12 | A Chinese medicinal composition and its application in relieving pain and skin itching |
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