CN1833699A - Quickly-acting antithrombotic and hemostatic medicine - Google Patents

Abstract

A quickly-acting Chinese medicine for treating atrial fibrillation, venous thrombus, heart disease attack, ischemic apoplexy and coronary heart disease is prepared from 6 Chinese-medicinal materials including saffron, Chinese angelica root, Chuan-xiong rhizome, liquorice root, etc.

Description

Quickly-acting antithrombotic, hemostatic medicine

The present invention relates to medical technical field, is to be the new drug that feedstock production forms with Chinese medicine.

At present, on the 7 big medical markets of the whole world, the number of suffering from thrombus disease is amazing: heart attack appears in annual nearly 1,600,000 people, and 1,500,000 people suffer the torment of apoplexy.According to a up-to-date result of study, at present the big medicine in the whole world has 8,500,000 people to suffer from chronic atrial fibrillation (AF), and up to 7% patient AF every once apoplectic seizure in a year.AF is a kind of common arrhythmia, and it can make the danger of apoplexy increase about 5 times.

Antithrombotic is Western medicine mostly at present, warfarin and clopidogrel are arranged, and warfarin is improper because of taking dose, can increase the danger of thrombosis or blood clotting, or anticoagulant therapy can increase the danger of thrombosis or blood clotting, needs prolongation use anticoagulation medicine inadequately.For fear of deficiency and the drug overdose of taking medicine, doctors generally grudge old people's opening clothes anticoagulation medicine.But the dangerous maximum of apoplexy takes place in the old people, if allow them use preventative anticoagulation medicine, they just might therefrom obtain maximum benefit.

The treatment of clopidogrel is renderd a service lower, also has the side effect of Western medicine class antithrombotic very big, as hemorrhage, tired, menorrhagia, drowsiness, vomiting, nauseating, also has drug dependence, is the true cause of prolonged illness refractory.

The purpose of the present invention Chinese medicine of rejuvenating China really solves thrombus disease, on the pathogeny many diseases rule together, parallel in the control agent, the medicine of regulating blood circulation, analgesia, hemostasis, antiinflammation, overcome the shortcoming and defect on the prior art.And quickly-acting antithrombotic, hemostatic new drug are provided, and get well sooner, promote the well-being of mankind.

New drug of the present invention is antithrombotic, the hemostatic medicine of realizing by following technical proposal, it is characterized in that being made up of following component:

Radix Hedysari 20-41% Stigma Croci 5-19%

Radix Angelicae Sinensis 15-39% Herba Wedeliae Wallichii 4-17%

Rhizoma Chuanxiong 12-30% Radix Glycyrrhizae 6-18%

Each composition ratio sum is 100%

The present invention adopts science orthogonal design and theory of Chinese medical science, and " healthy energy deposit in, heresy can not be done ", the generation of disease, development and blood circulation have confidential relation, so we want tonifying for deficiency syndrome, transfer its deficiency and excess, are just winning heresy and are going, its logical its logical and eliminating the pathogen.The present invention also meets " clinical medicine " and " rehabilitation medicine ", with the elite of the two combination is inventor's original idea, functions such as this new drug has embolism extinguishing, analgesia, stops blooding, enriches blood, QI invigorating, antiinflammatory are through repeated screening, test the clinical just best prescription of testing.

Do not have on " Pharmacopoea Chinensis " by retrieval, on a large amount of books and all do not have this medicine on the net, having on this quick-acting market does not have, this new drug is intravenous powder pin and oral capsule, be can using of causing of blood factor, can play and regulate blood circulation, regulate physiological function, so be ideal antithrombotic, hemostatic good medicine, men and women grown-ups and children can use, and has no side effect.

The clinical experiment report of new drug of the present invention:

One, atrial fibrillation (deficiency of both vital energy and Yin, stagnation of heart-blood, liver-yang are high partially)

Mr. Liu 75 years old, retired cadre, patient have hypertension for many years, often feel rather not to sleep at uncomfortable in chest, cardiopalmus, night, have a dizzy spell blurred vision.More feel staring spells near month, haltingly, yellow and thin fur, the red tongue purple, stringy and thready pulse and count is with tying generation.Examination of ocular fundus is: the bilateral ocular fundus arteriosclerosis 2-3 phase.The electrocardiogram prompting: atrial fibrillation (type fast), significantly along the clock transposition.Cholesterolemia is 310 milligrams.Medication 6 days, all diseases are clearly better, and pulse condition has not had knot generation.The electrocardiogram check is: sinus rhythm, electrocardiogram are roughly normal.Medication 20 days, cardiopalmus is uncomfortable in chest etc., and all diseases disappear, and stride is strong, vision is got better, and checks that cholesterolemia also reduced to normally.

Two, phlebothrombosis disease (thromboangiitis, the wet meridians, the internal resistance of stasis of blood poison, blood vessels stopped up unfavorable)

Mrs Liu 41 years old, the printing house workman, the patient is conscious, and sufficient big toe is ached, be to press and ache, day by day increase the weight of, connect after two weeks and inferior toe, shank feels cold, the outer edema of instep and internal malleolus has the pitting impression, and the colour of skin is darker, the pain increased during action, the dorsal artery of foot disappearance of beating, Western medicine diagnose is a thromboangiitis, once repeatedly treatment was not seen and was alleviated.The patient face flushing, the time vexed tachypnea is arranged, the back is aching and limp, greasy fur on tongue Huang, pulse condition stringy and rolling pulse.Logotype 7 days, shank feels cold, and the instep edema disappears, pain relief, turbid damp is separated, with 20 days, pain disappearance, the dorsal artery of foot recovery of beating.

Three, pulmonary infarction (pathogenic heat is violated lung, obstruction of collaterals by blood stasis, the stasis of blood does not go that then network is not peaceful)

Mrs Liu 46 years old, because of pulmonary infarction, beginning before month, apoplexy due to phlegm has blood, and is once invalid with haemostatic medicaments such as Chinese medicine decoction and injection of western medicine, and after surplus the examining, logotype new invention powder pin is i.e. hemostasis after 5 days, and symptom takes a turn for the better, reuse 4 days, rehabilitation entirely.

Four, heart attack (stagnation of heart-blood, cold coagulation humidity hysteresis)

CHENNU scholar 48 years old, the teacher, patient's morbidity just has spitting of blood, and spitting of blood often takes place later on.Over nearly 2 years, all be in hospital for several times every year.Menstruation disconnected 5 years.Haematemesis amount now is many, and is out of breath, sitting upright and being unable to lie flat, and perspiration cardiopalmus, dizziness, arrhythmia, heart rate 118 times/minute, heart circle enlarge, and the apical region of heart has three grades to the level Four systolic murmur, two to three grades of diastolic murmurs, liver under rib 5 centimetres.Mitral incompetence, pulmonary congestion, intravenous injection 3 days, conditions of patients improves, and reuse is 8 days continuously, all rehabilitations.

Five, cerebral infarction (cerebral thrombosis, apoplexy is gone into network, stasis of blood resistance blood vessels)

Mrs Liu 80 years old, excessively painstaking because of holding a birthday party, the five will fire utmost point, the QI and blood superinverse is harassed gods, sudden syncope, syncope, facial hemiparalysis, gnathospasma, acrocontracture, enuresis and encopresis.Be diagnosed as cerebral thrombosis through certain examination in hospital, control and do not have good the effect, invite and give diagnosis and treatment, card sees that the tongue fur white matter is dim, and thready and stringy pulse is puckery, took medicine 5 days, mind is gradually clear, and brothers change temperature, also can stretch in the wrongly, thinks food, and two just own consciousness were obeyed 10 days again, and all diseases disappear, and obey again 10 days, and patient can go shopping.

Six, coronary heart disease (qi depression to blood stasis)

Mr. Li 48 years old, cadre, the twinge of patient's thoracic dorsal, attach most importance to the left side, right arm is heavy aches, uncomfortable in chest calming the anger, nervous volume antiperspirant, pale complexion, extreme cold of the limbs, pain with the different the eleventh of the twelve Earthly Branches ester of nitrous acid news is alleviated slightly, blood pressure is 180/100mmHg, and Electrocardioscopy is undesired, points out left locular wall blood supply insufficiency, clothes new invention medicine 15 days, symptom is alleviated fully.It is normal that Electrocardioscopy recovers.

The male uses this medicine 159 examples, between 18 years old to 85 years old age, the course of disease 1 year with interior person's 55 examples, more than 1 year to 3 years with interior person's 56 examples, person's 48 examples more than 3 years.The women uses this medicine 170 examples, the age between 16 years old to 85 years old, the course of disease 1 year with interior person's 79 examples, more than 1 year to 3 years with interior 60 examples, person's 31 examples more than 3 years.

Whole healing person's (all normal) 275 examples by statistics, improvement person's 50 examples, nonresponder's 4 examples, total effective rate 95.38%.

Embodiment 1

Radix Hedysari 130 Stigma Croci 35

Radix Angelicae Sinensis 100 Herba Wedeliae Wallichii 34

Rhizoma Chuanxiong 60 Radix Glycyrrhizaes 38

Mix the back and make capsule and intravenous powder pin by special method.

Embodiment 2

Radix Hedysari 140 Stigma Croci 38

Radix Angelicae Sinensis 95 Herba Wedeliae Wallichii 32

Rhizoma Chuanxiong 55 Radix Glycyrrhizaes 39

Mix the back and make capsule and intravenous powder pin by special method.

Claims (3)

1, quickly-acting antithrombotic, hemostatic medicine, it is characterized in that by:

Radix Hedysari 20-41% Stigma Croci 5-19%

Radix Angelicae Sinensis 15-39% Herba Wedeliae Wallichii 4-17%

Rhizoma Chuanxiong 12-30% Radix Glycyrrhizae 6-18%

2, quickly-acting antithrombotic according to claim 1, hemostatic medicine is characterized in that being used for the preparation treatment and prevent the new drug of atrial fibrillation, phlebothrombosis disease, pulmonary infarction, heart attack, cerebral infarction (cerebral thrombosis), coronary heart disease.

3, quickly-acting antithrombotic according to claim 1, hemostatic medicine is characterized in that described medicine is a said dosage form on any pharmaceutics.