CN1824252A - Astragalus leech network ressel freeing capsule - Google Patents

Abstract

A Chinese medicine in the form of capsule for treating the apoplexy sequelae, such as hemiparalysis, numbness of limbs, deviation of eyes and mouth, etc, is prepared through decocting 15 Chinese-medicinal materials including astragalus root, ginseng, etc twice to obtain extract, mix it with the fine powder of 6 Chinese-medicinal materials including leach, ground bettle, etc, sieving, spraying the volatile oil of 4 Chinese-medicinal materials including Chinese angelica root, Chuan-xiong rhizome, etc, sieving, and loading in capsules.

Description

Astragalus leech network ressel freeing capsule

Technical field: the present invention relates to Chinese medicine preparation, relate in particular to and be applicable to Chinese medicine preparation that the paralytic recovers and preparation method thereof.

Background technology: cardiovascular and cerebrovascular disease is the two big principal diseases that threaten human health.Along with aged tendency of population, sickness rate is the trend of continuous rising.Apoplexy is again the main aspect that cardiovascular and cerebrovascular disease takes place, and morbidity is anxious, and mortality rate, relapse rate, disability rate are all very high, has brought white elephant for society and family.Apoplexy belongs to the traditional Chinese medical science " syndrome of blood stasis " category, and pathogenesis mostly is " deficiency in origin and excess in superficiality, blood stasis due to qi deficiency ".Traditional Chinese medical science QI and blood academic theory is thought, qi as the commander of blood, and blood being the mother of qi, and gas Lai Xuezai, blood rely gas capable, and the deficiency of vital energy is blood stasis then, and the capable then blood of gas is capable.At present, the sickness rate of cerebral infarction, cerebral arteriosclerosis is very high, owing to there is not specific drug, its death toll is in first, second position in the whole death toll in the world, and the sequela of Xing Chenging is brought very big misery as obstinates such as quadriplegia, facial hemiparalysis, slurred speech, numb limbs and tense tendons to patient thus.

Goal of the invention: the object of the present invention is to provide a kind of astragalus leech network ressel freeing capsule prescription that is applicable to stroke in convalescent stage sequela auxiliary treatment and preparation method thereof, the present invention has QI invigorating, invigorates blood circulation, the curative effect of collateral dredging.

Technical scheme:

Prescription portion rate of the present invention is:

Radix Astragali 310-510 Hirudo 100-300 Radix Ginseng 110-150 31-41 Radix Ophiopogonis Fructus Schisandrae Chinensis 50-80 Radix Angelicae Sinensis 50-80 Rhizoma Chuanxiong 50-80 Radix Ilicis Pubescentis 310-450 Radix Paeoniae Rubra 50-80 Caulis Spatholobi 50-80 Radix Polygoni Multiflori 130-180

Radix Salviae Miltiorrhizae 50-80 Flos Carthami 25-40 Herba Lycopi 25-40 Eupolyphaga Seu Steleophaga 25-40

Pheretima 300-400 Bombyx Batryticatus 5-8 Radix Curcumae 50-80 Rhizoma Curcumae Longae 30-40

Scorpio 10-15 Rhizoma Gastrodiae 10-20 Cortex Cinnamomi 10-15 Rhizoma Et Radix Notopterygii 30-40

Fructus Gleditsiae Abnormalis 5-8 Arisaema Cum Bile 10-20 Borneolum Syntheticum 10-20

Its manufacture method is as follows:

A, water intaking trematodiasis, Eupolyphaga Seu Steleophaga, Cortex Cinnamomi, Scorpio, Bombyx Batryticatus, Arisaema Cum Bile Six-element Chinese medicine are removed impurity respectively, dry up under 60 ° of-80 ° of low temperature wind, are ground into 150-200 order fine powder, sieving for standby;

B, get Radix Angelicae Sinensis, Rhizoma Chuanxiong, Radix Curcumae, Rhizoma Curcumae Longae four flavor Chinese medicines, extract volatile oil, standby in the receiving flask;

C, the medicinal residues of getting four flavor Chinese medicines among the above-mentioned steps b and the Radix Astragali, Radix Ginseng, Radix Ophiopogonis, five bundle, Radix Ilicis Pubescentis, Radix Paeoniae Rubra, Caulis Spatholobi, Radix Polygoni Multiflori Preparata, Radix Salviae Miltiorrhizae, Flos Carthami, Herba Lycopi, Pheretima, Rhizoma Gastrodiae, Rhizoma Et Radix Notopterygii, Fructus Gleditsiae Abnormalis ten five kinds of Chinese medicine, decoct with water twice, each two hours, after twice decocting liquid merging, filter out medicinal residues, filter liquor is concentrated into the clear paste that relative density is 1.20-1.25 (80 degree is surveyed), add fine powder among the above-mentioned steps a, mixing, 80 ° with interior cold drying after, be ground into fine powder;

D, get above-mentioned fine powder and convert to grind with Borneolum Syntheticum and mix, sieve, spray adds volatile oil among the above-mentioned step b, mixing;

E, fine powder after the above-mentioned mixing is incapsulated, promptly make finished product.

Embodiment: get the Radix Astragali 325 gram, Hirudo 130 grams, Radix Ginseng 130 grams, Radix Ophiopogonis 37.5 gram, Fructus Schisandrae Chinensis 65 grams, Radix Angelicae Sinensis 65 grams, Rhizoma Chuanxiong 65 grams, Radix Ilicis Pubescentis 325 grams, Radix Paeoniae Rubra 65 grams, Caulis Spatholobi 65 grams, Radix Polygoni Multiflori 162.5 grams, Radix Salviae Miltiorrhizae 65 grams, Flos Carthami 32.5 grams, Herba Lycopi's 32.5 grams, Eupolyphaga Seu Steleophaga 32.5 grams, Pheretima 325 grams, Bombyx Batryticatus 6.5 grams, Radix Curcumae 65 grams, Rhizoma Curcumae Longae 32.5 grams, Scorpio 13 grams, Rhizoma Gastrodiae 13 grams, Cortex Cinnamomi 13 grams, Rhizoma Et Radix Notopterygii 32.5 grams, Fructus Gleditsiae Abnormalis 6.5 grams, Arisaema Cum Bile 13 grams, Borneolum Syntheticum 13 gram, be produced as follows then:

A, water intaking trematodiasis, Eupolyphaga Seu Steleophaga, Cortex Cinnamomi, Scorpio, Bombyx Batryticatus, Arisaema Cum Bile Six-element Chinese medicine are removed impurity respectively, dry up under 60 ° of-80 ° of low temperature wind, are ground into 150-200 order fine powder, sieving for standby;

B, get Radix Angelicae Sinensis, Rhizoma Chuanxiong, Radix Curcumae, Rhizoma Curcumae Longae four flavor Chinese medicines, extract volatile oil, standby in the receiving flask;

C, the medicinal residues of getting four flavor Chinese medicines among the above-mentioned steps b and the Radix Astragali, Radix Ginseng, Radix Ophiopogonis, Fructus Schisandrae Chinensis, Radix Ilicis Pubescentis, Radix Paeoniae Rubra, Caulis Spatholobi, Radix Polygoni Multiflori Preparata, Radix Salviae Miltiorrhizae, Flos Carthami, Herba Lycopi, Pheretima, Rhizoma Gastrodiae, Rhizoma Et Radix Notopterygii, Fructus Gleditsiae Abnormalis ten five kinds of Chinese medicine, decoct with water twice, each two hours, after twice decocting liquid merging, filter out medicinal residues, filter liquor is concentrated into the clear paste that relative density is 1.20-1.25 (80 degree is surveyed), add fine powder among the above-mentioned steps a, mixing, 80 ° with interior cold drying after, be ground into fine powder;

D, get above-mentioned fine powder and convert to grind with Borneolum Syntheticum and mix, sieve, spray adds volatile oil among the above-mentioned step b, mixing;

E, fine powder after the above-mentioned mixing is incapsulated, every capsules 0.5 gram, finished product.

Beneficial effect: the present invention has QI invigorating, invigorates blood circulation, the effect of collateral dredging, is applicable to that the stroke in convalescent stage sequela shows as hemiplegia, numb limbs and tense tendons, facial hemiparalysis, dysphonia, lassitude person's auxiliary treatment.This medicine composition is reasonable, and processing technology is simple, and curative effect is outstanding, and good clinical Practical significance and promotional value are arranged.

Curative effect explanation of the present invention:

Treat apoplexy sequela hemiplegia patient 10 examples with astragalus leech network ressel freeing capsule year May in May, 2002 to 2005, and curative effect is better.

Patient analyzes: male 7 woman 3 in 10 examples, minimum 39 years old of age, maximum 72 years old, 41--60 year 6 people wherein, 61--70 year 3 people.The course of disease is the longest 5 years, and is the shortest 20 days, all is the inpatient.

Case history is selected:

1, be the main object of observation with apoplexy " apoplex involving the channels and collaterals ".

2, diagnostic criteria: the apoplex involving the channels and collaterals in " the apoplexy diagnosis criterion of therapeutical effect " formulated according to national tcm internal medicine association " be main, that is: hemiplegia, facial hemiparalysis, dysphonia.

3, medicine typing: blood stasis due to qi deficiency pattern of syndrome: have " apoplex involving the channels and collaterals " symptom, have shortness of breath and fatigue concurrently, tongue is dark, and tongue is white, deep-thready pulse, and string is little; Wind-phlegm blood stasis, numbness resistance venation disease type: have " apoplex involving the channels and collaterals " symptom, have concurrently and have a dizzy spell, tongue is dark, and tongue is thick in vain, stringy and rolling pulse.

4, CT examination is cerebral infarction or cerebral hemorrhage.

Observation index and method:

1, fills in " astragalus leech network ressel freeing capsule clinical observation table " in detail.

2, with " astragalus leech network ressel freeing capsule " the last fortnight, the Chinese and western medicine medicine of all treatment primary disease of stopping using.

3, forward and backward CT, the hemorheology done of treatment.

4, write down limbs, language situation of change weekly.

5, usage and consumption: each oral 4 of astragalus leech network ressel freeing capsule, a twice-daily.

6, the course of treatment: be a course of treatment all around, all make efficacy evaluation after each patient finishes for one course of treatment.

Therapeutic outcome:

1, pattern of syndrome and cerebral location of lesions analysis:

(1) this is organized in 10 examples, all is " apoplex involving the channels and collaterals ".Blood stasis due to qi deficiency pattern of syndrome 8 examples; Wind-phlegm blood stasis, numbness resistance venation disease type 2 examples.

(2) CT examination: the left side basal ganglia region is blocked 3 examples, and the right side basal ganglia region is blocked 2 examples, right lacuna 2 examples, double-basis coxopodite district 1 example, tricorn 1 example, left brain stem district 1 example; Check 6 examples, the focus of infarct end disappears.

2, efficacy assessment standard: by whole nation unified standard.Adopt scoring method, divide the level Four evaluation with comprehensive function recovery extent such as limbs and language at last:

(1) the basic healing: take care of oneself, open can be done labor in general;

(2) produce effects: life is taken care of oneself substantially, and has partial function incomplete, can do simple housework;

(3) effective: but cane walking, part is taken care of oneself, and the people that still needs helps;

(4) invalid: treatment back nothing is clearly better.

According to above-mentioned evaluation criteria, in 10 cases, 5 examples that are almost recovered, produce effects 3 examples, effective 1 example, invalid 1 example.

Typical case's case history one: storyteller's fan Du, man, 45 years old, Dian Shang town, Huguan County, Shanxi Province Shi Yu people from village.On May 6th, 97 was in hospital for the first time, suffer from left limb unable, movable unfavorable 5 years, increase the weight of left hemiplegia, aphasia, facial hemiparalysis, lassitude and weak, dark tongue quality the bimester of near.Tcm diagnosis: apoplexy, apoplex involving the channels and collaterals.Dialectical: blood stasis due to qi deficiency disease type.CT examination: right side lacunar infarction.Hemorheology is learned, blood viscosity increases, the clothes astragalus leech network ressel freeing capsule, each 4,2 times on the one, all around after, hemiplegia and language function recover, and take care of oneself open, free stride, the basic healing.Followed up a case by regular visits in 2005 10, the body constitution stalwartness can be done general heavy physical labour.

Typical case's case history one: kingdom celery, woman, 49 years old, Linzhou City, Henan security personnel family members institute.On February 27th, 2002 was in hospital.Left side hemiplegia 40 days, the facial hemiparalysis dysphonia, fatigue and weakness, tongue limit ecchymosis, tongue is thick in vain, stringy and thready pulse.Tcm diagnosis: apoplexy, apoplex involving the channels and collaterals, blood stasis due to qi deficiency disease.CT examination, right basal ganglia region infraction.Method of treatment: benefiting QI for activating blood circulation is promoted blood circulation.The clothes astragalus leech network ressel freeing capsule, each 4,3 times on the one, all around after, stride voluntarily, language performance is normal, the basic recovery followed up a case by regular visits to euthesia in August, 2005.

Conclusion: this medicine is better to the blood stasis due to qi deficiency in the apoplexy ' apoplex involving the channels and collaterals ' and wind-phlegm blood stasis numbness resistance venation disease curative effect, blood stasis due to qi deficiency especially, and it is good more to take the long curative effect of this medication Cheng Yue, has example clothes to take a turn for the better for one course of treatment, recovers substantially after obeying for 3 courses of treatment.

Claims (1)

1, the preparation method of astragalus leech network ressel freeing capsule is characterized in that, its manufacture method is as follows:

A, water intaking trematodiasis, Eupolyphaga Seu Steleophaga, Cortex Cinnamomi, Scorpio, Bombyx Batryticatus, Arisaema Cum Bile Six-element Chinese medicine are removed impurity respectively, dry up under 60 ° of-80 ° of low temperature wind, are ground into 150-200 order fine powder, sieving for standby;

B, get Radix Angelicae Sinensis, Rhizoma Chuanxiong, Radix Curcumae, Rhizoma Curcumae Longae four flavor Chinese medicines, extract volatile oil, standby in the receiving flask;

C, the medicinal residues of getting four flavor Chinese medicines among the above-mentioned steps b and the Radix Astragali, Radix Ginseng, Radix Ophiopogonis, Fructus Schisandrae Chinensis, Radix Ilicis Pubescentis, Radix Paeoniae Rubra, Caulis Spatholobi, Radix Polygoni Multiflori Preparata, Radix Salviae Miltiorrhizae, Flos Carthami, Herba Lycopi, Pheretima, Rhizoma Gastrodiae, Rhizoma Et Radix Notopterygii, Fructus Gleditsiae Abnormalis ten five kinds of Chinese medicine, decoct with water twice, each two hours, after twice decocting liquid merging, filter out medicinal residues, filter liquor is concentrated into the clear paste that relative density is 1.20-1.25 (80 degree is surveyed), add fine powder among the above-mentioned steps a, mixing, 80 ° with interior cold drying after, be ground into fine powder;

D, get above-mentioned fine powder and convert to grind with Borneolum Syntheticum and mix, sieve, spray adds volatile oil among the above-mentioned step b, mixing;

E, fine powder after the above-mentioned mixing is incapsulated, promptly make finished product.