CN1824246A - Medicinal film vest medicinal film plaster for treating coronary heart disease stenocardia and preventing myocardial infaction and its preparation method - Google Patents
Medicinal film vest medicinal film plaster for treating coronary heart disease stenocardia and preventing myocardial infaction and its preparation method Download PDFInfo
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- CN1824246A CN1824246A CN 200510020384 CN200510020384A CN1824246A CN 1824246 A CN1824246 A CN 1824246A CN 200510020384 CN200510020384 CN 200510020384 CN 200510020384 A CN200510020384 A CN 200510020384A CN 1824246 A CN1824246 A CN 1824246A
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Abstract
A Chinese medicine used to prepare the medicinal film vest and plaster for treating coronary heart disease and angina pectoris and preventing myocardial infarction is prepared from 5 Chinese-medicinal materials including Oenothera odorate oil, notopterygium root, turmeric, myrrh, etc through proportional mixing, extracting active components, adding additive and shaping.
Description
[technical field] the present invention relates to a kind of treatment angina pectoris, and medicine for external use film vest, the medicine film of prevention myocardial infarction paste and preparation method.Belong to the field of Chinese medicines.
[background technology] coronary heart disease is the most important cause of death in the cardiovascular disease.Coronary heart disease is that coronary atherosclerosis makes its narrow or spasm and the ischemic heart desease that causes.Clinical acutely show effect repeatedly with transience, squeezing property, asphyxiating chest pain, companion's dyspnea chronicly is the persistence precordial dull pain, feels oppressed and do not relax and the common arrhythmia of physical examination.Wu's sea rosy clouds coronary heart disease external used medicine chest protector bag described in (application number) 03215222 is buckled and is constituted by strip cloth bag, degree of tightness bag, woollen goods in the document, and the medicine stamen is equipped with at corresponding seat with heart in the bag.But still can not be satisfactory.The Chinese medicine pad pasting of Ma Delin described in (application number) 02146524, form by thick paste and other material that effective component extractings such as Rhizoma Chuanxiong, Lignum Santali Albi, Radix Curcumae, Lignum Aquilariae Resinatum, Rhizoma Cyperi are made, this pad pasting has the effect of blood vessel dilating allevating angina pectoris, but people need seek better Drug therapy angina pectoris, the prevention myocardial infarction.
[summary of the invention] therefore, in order to treat angina pectoris better, the prevention myocardial infarction just needs a kind of both antianginals, the root of the administration for a long time treatment that goes out the cause of disease again.Up to the present, also do not find the report of any relevant medicine of the present invention and bonded with it Chinese medicine external agent.I am through repeatedly research for many years, and by clinical multiple authentication, finally invented transdermal administration " unidirectional medicine film vest ", " two-dimentional medicine film vest ", " the sticking type medicine film in limit pastes " of making and reached " sticking type controlled release medicine film pastes " by concentrated medicament that the advantages of good skin compatibility and infiltration rate are arranged and adjuvant, its curative effect highly significant of drug combination of grease removal in its medicinal liquid, activating blood circulation to dissipate blood stasis, warming YANG collateral dredging, dress or be attached to left breast pareordia and breastbone and left breast lateral wall, " subsides of medicine film " only have the bonding skin of small size, and large tracts of land medicine film liquid then directly reaches heart thoroughly." vest " buckled by breast, the effect that shoulder breast button is adjusted chest measurement size and elastic fibers makes its medicine film be close to the through heart of skin transdermal administration, and " vest " back elastic fibers mainly is oblique tight bundle, not influencing thoracic expansion breathes, can use for a long time and continue medication, such combination can coronary artery dilator with antianginal, again can long lasting " atherosis " focus that disappears gradually, make coronary blood flow unimpeded, to alleviate and to eliminate the generation of angina pectoris and prevention myocardial infarction, " vest " can be worn, take off repeated use, the medicine film is interchangeable, and is extremely easy to use, thereby finished the present invention.
Purpose of the present invention just provided a kind of have special effect, quick-acting, at a high speed, steady imitate, long-acting and treatment is convenient and the pharmaceutical composition and the preparation method of the transdermal administration " unidirectional medicine film vest " that has no side effect, " two-dimentional medicine film vest ", " the sticking type medicine film in limit pastes ", " sticking type controlled release medicine film pastes ".
Medicament selection of the present invention Radix Oenotherae erythrosepalae oil, Rhizoma Et Radix Notopterygii, Fructus Litseae, Rhizoma Curcumae Longae, Myrrha and protecting film, casing play, impervious backing layer, fibrous layer, controlled release layer, elastic fibers, breast woollen goods buckle, take on that breast woollen goods are buckled, elastic force shoulder belt, the combination of elastic force back of the body shoulder belt make.In the selection of medicine.Select Radix Oenotherae erythrosepalae oil, because of Radix Oenotherae erythrosepalae oil contains acid and gamma-linolenic, the blood fat of disappearing is arranged, antiatherogenic effect.Select Rhizoma Et Radix Notopterygii for use, because of Rhizoma Et Radix Notopterygii suffering, hardship, temperature, cold expelling, dehumidifying, pain relieving.Select Fructus Litseae for use, because of Fructus Litseae, suffering, temperature, return spleen, stomach, kidney, urinary bladder channel, warming spleen and stomach for dispelling cold, promoting the circulation of QI to relieve pain, be used for coldness and pain in the epigastrium etc., select Rhizoma Curcumae Longae for use, because of Rhizoma Curcumae Longae suffering, hardship, temperature, return liver, spleen channel, the removing blood stasis circulation of qi promoting, removing obstruction in the collateral to relieve pain is used for the pain in chest and hypochondrium of caused by energy stagnation and blood stasis.Select Myrrha for use, because of Myrrha hardship, suffering, flat, GUIXIN, liver spleen channel, eliminating stasis to stop pain, detumescence and promoting granulation are controlled trusted subordinate small piece of land surrounded by water pain.More than 5 flavor medicines share, strengthened activating stagnated YANG, removing obstruction in the collateral to relieve pain, fat blood stasis dispelling effect disappears.
Also have Radix Angelicae Sinensis, Rhizoma Zingiberis, Radix Salviae Miltiorrhizae combination in order to reach better therapeutic medicine of the present invention.Radix Angelicae Sinensis, Gan Xin, hardship, temperature, GUIXIN, liver, spleen channel, the promoting blood circulation and stopping pain of enriching blood.Rhizoma Zingiberis, hot, hot, return spleen, the heart, lung meridian, warming spleen and stomach for dispelling cold, recuperating depleted YANG are promoted blood circulation, the dampness expectorant.Radix Salviae Miltiorrhizae, bitter, be slightly cold, GUIXIN, pericardium, Liver Channel, blood circulation promoting and blood stasis dispelling, removing heat from blood disappear pain, nourishing blood to tranquillize the mind, cold partially hot warm because of it to make all medicines, help all medicine blood circulation promoting and blood stasis dispelling again.In order to bring into play the effect of medicine best, medicine of the present invention also has the Borneolum Syntheticum combination, Borneolum Syntheticum suffering, hardship, is slightly cold, and GUIXIN spleen, lung meridian help above drug transdermal to have one's ideas straightened out.More than 9 the flavor medicines make up its Wen Tongxin arteries and veins, the effect of removing obstruction in the collateral to relieve pain, the fat blood stasis dispelling that disappears is stronger.The consumption of drug regimen of the present invention is also groped to sum up to draw through the inventor in a large number, and each group component has good curative effect in the following weight parts scope.
Radix Oenotherae erythrosepalae oil 1-2 part, Rhizoma Et Radix Notopterygii 8-10 part, Fructus Litseae 7-9 part, Rhizoma Curcumae Longae 6-8 part, Myrrha 6-8 part.
Be preferably: 1 part of Radix Oenotherae erythrosepalae oil, 9 parts of Rhizoma Et Radix Notopterygiis, 8 parts of Fructus Litseae, 7.5 parts in Rhizoma Curcumae Longae, 7 parts of Myrrhas.
The consumption of the further each component of medicine of the present invention is Radix Oenotherae erythrosepalae oil 1-2 part, Rhizoma Et Radix Notopterygii 8-10 part, Fructus Litseae 7-9 part, Rhizoma Curcumae Longae 6-8 part, Myrrha 6-8 part, Radix Angelicae Sinensis 2-5 part, Rhizoma Zingiberis 2-4 part, Radix Salviae Miltiorrhizae 2-4 part, Borneolum Syntheticum 0.5-2 part.
Be preferably: 1 part of Radix Oenotherae erythrosepalae oil, 9 parts of Rhizoma Et Radix Notopterygiis, 8 parts of Fructus Litseae, 7.5 parts in Rhizoma Curcumae Longae, 7 parts of Myrrhas, 3 parts of Radix Angelicae Sinensis, 3 parts of Rhizoma Zingiberiss, 3 parts of Radix Salviae Miltiorrhizaes, 1 part of Borneolum Syntheticum.
Radix Oenotherae erythrosepalae oil described in the present invention is that acquisition is got in the seed cold pressing of the red calyx Radix Oenotherae erythrosepalae of onagraceae plant.
Medicine of the present invention can adopt the several different methods of Chinese medicine preparation to make various percutaneous drug administration preparations.For example can be except that Radix Oenotherae erythrosepalae oil, Borneolum Syntheticum with crude drug; mixing with ethanol extraction after concentrating under reduced pressure again; but for each crude drug is brought into play drug effect better; to obtain better curative effect; to Rhizoma Et Radix Notopterygii, Fructus Litseae, Rhizoma Curcumae Longae, Myrrha, carrying out steam distillation earlier, to extract volatile oil standby; concentrate with atmospheric distillation behind the surplus medicinal residues ethanol extraction; Radix Angelicae Sinensis, Rhizoma Zingiberis are directly with concentrating under reduced pressure behind the ethanol extraction; concentrate with atmospheric distillation behind the Radix Salviae Miltiorrhizae ethanol extraction; but these all can not be used to limit protection scope of the present invention, can adopt supercritical CO as Radix Angelicae Sinensis, Rhizoma Zingiberis, Rhizoma Curcumae Longae etc.
2Extraction Radix Angelicae Sinensis, Rhizoma Zingiberis, Rhizoma Curcumae Longae essential oil.The pharmaceutically active composition concentrated solution can add polymer, adhesive and penetration enhancer such as menthol etc.
Preferably, the preparation method of pharmaceutically active compositions liquid of the present invention is as follows:
(1) with Rhizoma Et Radix Notopterygii, Fructus Litseae, Rhizoma Curcumae Longae, the Myrrha of described weight proportion, extracts volatile oil with steam distillation respectively, the Rhizoma Et Radix Notopterygii volatile oil, Fructus Litseae volatile oil, Rhizoma Curcumae Longae volatile oil, the Myrrha volatile oil that obtain are merged the airtight brown bottle of packing into, get mixed volatilization oil, standby, surplus medicinal residues filter is done stand-by.
(2) will filter Rhizoma Et Radix Notopterygii, Fructus Litseae, the Rhizoma Curcumae Longae medicinal residues done and merge in the container of packing into, and add 3 times of amounts of ethanol of 95% ,≤30 ℃ are soaked after 12 hours and to stir once in per 10 minutes.Soak and leached extracting solution in 3 hours, extracting solution is incorporated with in the graduated container flings to ethanol, be concentrated into 1/10-1/15, obtain concentrated solution 1 with atmospheric distillation.
(3) will filter the medicinal residues of doing that do not have and pack in the container, and add 3 times of amounts of ethanol of 95% ,≤30 ℃ are soaked after 12 hours and to stir once in per 10 minutes.Soak and leached extracting solution in 3 hours, extracting solution is incorporated with in the graduated container flings to ethanol, be concentrated into 1/10-1/15, obtain concentrated solution 2 with atmospheric distillation.
If also, except that Borneolum Syntheticum, all pulverize 30-60 order sieving for standby with Radix Angelicae Sinensis, Rhizoma Zingiberis, Radix Salviae Miltiorrhizae, Borneolum Syntheticum combination.
Its preparation method is:
(1) Radix Angelicae Sinensis is packed into add 3 times of amounts of 85% ethanol in the container and stirred once in per 10 minutes ,≤30 ℃ were soaked 5 hours, and leached extracting solution, according to said method extract twice, extracted twice liquid is merged, with distillation under vacuum (≤45 ℃), be concentrated into 1/10-1/15, get the Radix Angelicae Sinensis concentrated solution.
(2) Rhizoma Zingiberis is packed into add 3 times of amounts of 85% ethanol in the container and stirred once in per 10 minutes ,≤30 ℃ were soaked 5 hours, leached extracting solution, according to said method extracted twice.Extracted twice liquid is merged,, be concentrated into 1/10-1/15, get the Rhizoma Zingiberis concentrated solution with distillation under vacuum (≤45 ℃).
(3) Radix Salviae Miltiorrhizae is packed in the container, add 95% ethanol.Water bath with thermostatic control≤35 ℃ warm macerating stirred once after 12 hours in per 10 minutes, soaked 2 hours, leached extracting solution, according to said method extracted twice.Extracted twice liquid is merged, fling to ethanol, be concentrated into 1/10-1/15, obtain the Radix Salviae Miltiorrhizae concentrated solution with atmospheric distillation.
(4) Borneolum Syntheticum is used 95% dissolve with ethanol by 1: 1.5, obtain the pure liquid of ice.
(5), just obtained pharmaceutically active composition concentrated solution of the present invention with Radix Oenotherae erythrosepalae oil, mixed volatilization oil, concentrated solution 1, concentrated solution 2, merge with Radix Angelicae Sinensis concentrated solution, Rhizoma Zingiberis concentrated solution, Radix Salviae Miltiorrhizae concentrated solution, the pure liquid of ice.
The method of pharmaceutically active composition concentrated solution and adjuvant combination is:
(1) general fiber, elastic fibers are buckled material with woollen goods and become the Wearable vest, promptly get " accurate vest ".
(2) impermeable backing layer is connected on the casing play, has obtained the skeleton backing layer.
(3) the pharmaceutically active composition concentrated solution is sprayed on the skeleton face of skeleton backing layer; must contain the medicinal liquid casing play, wherein casing play is that 30-35%, pharmaceutically active compositions liquid are 65-70%, connects upper protective film; promptly obtained " transdermal administration medicine film " of the present invention, be called for short " medicine film ".
(4) the medicine symphysis is connected on the left breast pareordia and the breastbone position of accurate vest, has promptly obtained " unidirectional transdermal administration medicine film vest " of the present invention, be called for short " unidirectional medicine film vest ".
(5) the medicine symphysis being connected on the left breast pareordia of accurate vest and breastbone position and left breast outside face is left oxter portion, has promptly obtained " two-way two-dimentional transdermal administration medicine film vest " of the present invention, is called for short " two-dimentional medicine film vest ".
(6) casing play being divided into 4 parts is connected and has the pressure-sensitive stick and above the backing layer of area greater than casing play; spraying pharmaceutically active composition concentrated solution is in the skeleton face; connect protecting film, promptly obtained " peripheral stick type transdermal administration medicine film pastes " of the present invention, be called for short " the sticking type medicine film in limit pastes ".
(7) the pharmaceutically active composition concentrated solution is sprayed on the skeleton face of skeleton backing layer; controlled release layer with holes in the connection; on controlled release layer, coat the adhesive of band pressure-sensitive and stick protecting film; promptly obtained " subsides of stick type percutaneous controlled-release administration medicine film " of the present invention, be called for short " sticking type controlled release medicine film pastes ".
Externally applied transdermal administration of the present invention " medicine film vest ", " subsides of medicine film " have coronary blood flow increasing, antianginal, anti-coronary atherosclerosis, improve effects such as cardiac function.Be used for the treatment of angina pectoris, the prevention myocardial infarction.
[description of drawings] Fig. 1: " unidirectional medicine film vest ", 7. breast woollen goods button, 8. take on woollen goods button, 9. elastic force braces (not drawing dotted line), 10. elastic force shoulder belt, all the other are elastic fibers, the film of can changing dressings.Fig. 2 is the main pseudosection of " Fig. 1 " A-A.Fig. 3: " two-dimentional medicine film vest ", 7. breast woollen goods button, 8. take on woollen goods button, 9. elastic force braces (not drawing dotted line), 10. elastic force shoulder belt, (11) elastic force back of the body shoulder belt (not drawing dotted line), all the other are elastic fibers, the film of can changing dressings.Fig. 4 is the main pseudosection of " Fig. 3 " B-B, 1. impermeable backing layer, 2. contains medicinal liquid casing play, 3. protecting film, 4. fibrous layer, 5. fiber controlled release layer, 6. elastic fibers.Fig. 5: " limit sticking type medicine film paste ", Fig. 6 be the 1. impermeable backing layer of the main pseudosection of " Fig. 5 " C-C, 2. contain the medicinal liquid casing play, 3. with the adhesive layer of pressure-sensitive, 4. protecting film.Fig. 7-(1), Fig. 7-(2): " sticking type controlled release medicine film paste ", Fig. 8 be the 1. impermeable backing layer of main pseudosection of " Fig. 7-(1), Fig. 7-(2) " D-D, 2. contain the medicinal liquid casing play, 3. with the adhesive layer of pressure-sensitive, 4. protecting film, 5. controlled release layer with holes.
[specific embodiment] is following further sets forth beneficial effect of the present invention by clinical treatment.The present invention's " unidirectional medicine film vest ", " two-dimentional medicine film vest ", " the sticking type medicine film in limit pastes ", " sticking type controlled release medicine film pastes ", the treatment angina pectoris that continues medication, the clinical sight of prevention myocardial infarction is looked into.Receive out-patient's totally 28 examples, male 19 examples, women 9 examples, men and women's ratio 2: 1.Age 45-55 year 4 examples, 56-60 year 7 examples, 61-70 year 10 examples, 7 examples more than 70 years old.Government functionary's 6 examples wherein, teacher's 3 examples, other personnel's 4 examples, retired cadre's 5 examples, retired professor's 4 examples, other retired person 6 examples.
Two, diagnostic criteria
(1) tcm clinical practice diagnosis basis (thoracic obstruction)
Stuffy pain over the chest, the serious thorough pain of chest pain then, dyspnea with short breath, meet labor what for, companion's cardiopalmus, dysphoria and insomnia, dizziness, touching difficulty more.The bluish lip purple, red tongue is few bitter or purple dark, and the light red tongue white fur is greasy also common, rapid pulse, heavy or knot generation.
Five pattern of syndrome of the clinical general branch of the thoracic obstruction, stagnation of heart-blood, the turbid Yong Sai of expectorant, YIN-cold stagnate heart deficiency of the kidney yin, deficient and weak YANG QI.
(2) doctor trained in Western medicine clinical diagnosis foundation
Angina pectoris: divide classical angina and atypical angina pectoris.
5 characteristics of classical angina: the chest pain that 1. breaks out often is positioned at sternal body epimere or rear, stage casing, 2. is constriction, asphyxiating, 3. lasts of short duration general lasting 1～5 minute; 4. inducement is often arranged, as fatigue, excitement, heavy meal, catch cold etc., 5. have a rest or contain nitroglycerine tablets and can alleviate rapidly.
Atypical angina pectoris: angina pectoris can be positioned at left breast pareordia or epigastrium.Be radiated to left omoplate, left oxter or right front breast, pain is lighter, or only feels the left front breast discomfort of feeling oppressed.
Clinically often be divided into two types:
(1) fatigue angina pectoris is characterized in that being brought out by motion or other situation that increases myocardium requirementing keto quantity, is divided into again: hair style fatigue angina pectoris 1., the course of disease in 1 month, the past do not have or the past angina pectoris was arranged but the several months number do not send out.2. stable type fatigue angina pectoris, the course of disease continues more than one month or one month.3. deterioration type fatigue angina pectoris, original stable angina pectoris attack times, the order of severity and persistent period increase the weight of suddenly, and cause that the activity of outbreak also falls as follows, contain with the nitroglycerin curative effect to go down.
(2) spontaneous angina pectoris, characteristics are that chest pain outbreak does not have obvious relation with the increase of myocardium requirementing keto quantity, promptly do not have obvious inducement or have a rest, night-time attack, the persistent period is longer, degree is heavier, and is difficult for being the nitroglycerin alleviation.
Acute myocardial infarction: clinical commonly original stable angina pectoris becomes instability mode, or does not previously have angina pectoris, occurs angina pectoris suddenly, and outbreak is frequent, and its character is similar to angina pectoris with the position.1. pain but degree is more violent often is unbearably squeezing, suffocates, even " dying sense ", is 1～2 hour to more than 10 hours with the profuse sweating persistent period.2. heart failure and shock.3. arrhythmia etc.
Three, case is selected and Therapeutic Method:
(1) case is selected
1. slight fatigue angina pectoris, usual activity does not have symptom to occur, and trotting as the 3rd buildings or level land on the prudent thing then causes angina pectoris person, often needs general anti-anginal drug of clothes or blood circulation promoting regulates qi Chinese patent medicine.
2. moderate fatigue angina pectoris, usual discomfort uncomfortable in chest, general activity is restricted slightly, does the anxious step slightly then to cause angina pectoris, pant and breathe hard as empty-handed last the 3rd buildings or on the level land, often needs obey nitroglycerin.
3. slight spontaneous angina pectoris is often felt the pain of suppressing uncomfortable in chest, and idol has the outbreak angina pectoris, and degree is lighter, and the persistent period is short, and is difficult for alleviating for nitroglycerin.
4. moderate spontaneous angina pectoris, typical angina pectoris, and show effect for several times every day, about each 10 minutes persistent period, be difficult for being the nitroglycerin alleviation.
5. various pattern of syndrome of the traditional Chinese medical science thoracic obstruction
The slight thoracic obstruction: often feel the suffocating pain over the chest discomfort, shortness of breath and palpitation, but symptom is lighter, no intermittent pulse.
The moderate thoracic obstruction: remove usual suffocating pain over the chest, and angina pectoris attacks is arranged 1～2 every day, or chest pain radiating to the back during outbreak, moving then pant bluish lip purple, intermittent pulse.
(2) Therapeutic Method
1. slight fatigue, spontaneous angina pectoris or the slight thoracic obstruction.
(1) dresses " unidirectional medicine film vest ", single card " the sticking type medicine film in limit pastes " or " sticking type controlled release medicine film pastes " left breast pareordia transdermal medicine for treating.
(2) if take on arm, the conduction of left oxter then wearing " two-dimentional medicine film vest " or subsides " subsides of medicine film " Chu left side breast pareordia and breastbone and left breast lateral wall transdermal medicine for treating left.
Dressed in (3) 24 hours, pad pasting.
(4) changed dressings film once in per 10 days, continuous one month.
2. moderate fatigue, spontaneous angina pectoris or the moderate thoracic obstruction.
(1) dresses " two-dimentional medicine film vest " or subsides " subsides of medicine film " in left breast pareordia and breastbone and left breast lateral wall transdermal medicine for treating.
Dressed in (2) 24 hours, pad pasting.
(3) changed dressings film once in per 5 days, continuous one month.
If re-use after pad pasting makes skin allergy wait to eliminate.
Four, efficacy assessment standard: the test method main points, more than the patient with angina pectoris of light moderate do not obey the logical medicine of other anti-heart strand in the phase of receiving treatment, after treating one month, follow up a case by regular visits to.
Produce effects: cardinal symptoms such as angina pectoris disappear, not outbreak in three months.
Take a turn for the better: cardinal symptoms such as angina pectoris alleviate, and idol has symptom to occur in three months, but some patient's spontaneous remission also can be refused to obey Nitrates or other active remedy if need take medicine, and obeys general blood circulation promoting regulates qi Chinese patent medicine, can alleviate as FUFANG DANSHEN PIAN etc.
Invalid: various symptoms are preceding identical with treatment.
Increase the weight of: pain attack times, degree, persistent period increase the weight of to some extent.
Five, therapeutic outcome is seen (table one)
Table one is light, moderate 25 examples curative effect after treating is seen and looked into
| Treatment time (my god) | Produce effects | Take a turn for the better | Invalid | Increase the weight of | Effective percentage % | ||||
| The example number | Obvious effective rate % | The example number | Improvement rate % | The example number | Inefficiency % | The example number | Add-on % | ||
| 5 | 10 | 40 | 14 | 56 | 1 | 4 | 0 | 0 | 96 |
| 10 | 13 | 52 | 12 | 48 | 0 | 0 | 0 | 0 | 100 |
| 15 | 16 | 64 | 9 | 36 | 0 | 0 | 0 | 0 | 100 |
| 20 | 20 | 80 | 5 | 20 | 0 | 0 | 0 | 0 | 100 |
| 30 | 22 | 88 | 3 | 12 | 0 | 0 | 0 | 0 | 100 |
Six, 3 example one's mid-50s male myocardial infarction conditions of patients take a turn for the better leave hospital back 1 example dress the present invention's " two-dimentional medicine film vest " in addition 2 examples use " the sticking type medicine film in limit pastes " " sticking type controlled release medicine film pastes " to be affixed on left breast pareordia and breastbone and left breast lateral wall transdermal administration prophylactic treatment three months respectively.
Method: 1, dressed in 24 hours, the pad pasting administration.
2, per 5 days of first month changed dressings film once.
3, changed dressings film once in the second month per 10 days.
4, changed dressings film once in three month per 15 days.
If re-use after pad pasting makes skin allergy wait to eliminate.
Efficacy assessment standard: during receiving treatment, do not obey other antianginal drug, after treating three months, follow up a case by regular visits to.
Produce effects: myocardial infarction symptom not outbreak in 2 years.
Take a turn for the better: the chest pain attack times reduces at ordinary times, the persistent period shortens, degree alleviates 1 year myocardial infarction of not showing effect.
Invalid: the state of an illness is preceding identical with treatment.
Increase the weight of: myocardial infarction pain attack times, persistent period, degree increase the weight of.
Prophylactic treatment: the results are shown in (table 2)
Table 2 prophylactic treatment after 3 months 2 years symptoms, sign improve situation
| Symptom and sign | Chest pain, feel oppressed and to the conduction of left arm, left oxter | Morning, chest pain each chest pain radiating to the back dyspnea that shows effect had dying sense companion profuse sweating | The bluish lip purple | Heart rate/minute | Electrocardiogram | PD trend |
| Before the treatment | Outbreak every day for several times, no matter fatigue or tranquillization, the clothes nitroglycerin can be alleviated | The annual outbreak of 3 routine patients for several times, clothes nitroglycerin heterodyne or invalid, the rescue of once being admitted to hospital for 3 times | Often occur | 90～100 | Undesired | Carry out sexual development |
| After the treatment | Mild degree appears after 1 year once in a while; But spontaneous remission, or only take Fufang Danshen Pian and other blood circulation promoting regulates qi Chinese patent drug and can alleviate | 3 routine patients all once not outbreaks in 2 years | Do not occur | About 85 | Normal range | Alleviate gradually |
Pasted, glue type controlled release medicine film and paste with unidirectional medicine film vest, two-dimentional medicine film vest, the sticking type medicine film in limit at three months in a word, treatment angina pectoris 25 examples, prophylactic treatment myocardial infarction 3 examples, produce effects 25 examples as a result, 3 examples that take a turn for the better, obvious effective rate 89.3%, improvement rate 10.7%, total effective rate 100%.
Come further to set forth the preparation method of transdermal administration of the present invention " medicine film vest ", " subsides of medicine film " by the following examples.
＜embodiment 1〉preparation of externally applied transdermal administration of the present invention " two-dimentional medicine film vest ":
(1) with Radix Oenotherae erythrosepalae oil 2g, Rhizoma Et Radix Notopterygii 10g, Fructus Litseae 9g, Rhizoma Curcumae Longae 8g, Myrrha 8g, equal crushing screening 20-50 order except that Radix Oenotherae erythrosepalae oil.Extract volatile oil with steam distillation respectively, Rhizoma Et Radix Notopterygii volatile oil, Fructus Litseae volatile oil, Rhizoma Curcumae Longae volatile oil, the Myrrha volatile oil that obtains merged the airtight brown bottle of packing into, get mixed volatilization oil, standby, surplus medicinal residues filter is done stand-by.
(2) will filter Rhizoma Et Radix Notopterygii, Fructus Litseae, the Rhizoma Curcumae Longae medicinal residues done and merge in the container of packing into, and add 3 times of amounts of ethanol of 95% ,≤30 ℃ are soaked after 12 hours and to stir once in per 10 minutes.Soak and leached extracting solution in 3 hours, extracting solution is incorporated with in the graduated container flings to ethanol, be concentrated into 1/10-1/15, obtain concentrated solution 1 with atmospheric distillation.
(3) will filter the medicinal residues of doing that do not have and pack in the container, and add 3 times of amounts of ethanol of 95% ,≤30 ℃ are soaked after 12 hours and to stir once in per 10 minutes.Soak and leached extracting solution in 3 hours, extracting solution is incorporated with in the graduated container flings to ethanol, be concentrated into 1/10-1/15, obtain concentrated solution 2 with atmospheric distillation.
If also, except that Borneolum Syntheticum, all pulverize 30-60 order sieving for standby with Radix Angelicae Sinensis 5g, Rhizoma Zingiberis 4g, Radix Salviae Miltiorrhizae 4g, Borneolum Syntheticum 2g combination.Its compounding method is:
(1) Radix Angelicae Sinensis is packed into add 3 times of amounts of 85% ethanol in the container and stirred once in per 10 minutes ,≤30 ℃ were soaked 5 hours, and leached extracting solution, according to said method extract twice, extracted twice liquid is merged, with distillation under vacuum (≤45 ℃), be concentrated into 1/10-1/15, get the Radix Angelicae Sinensis concentrated solution.
(2) Rhizoma Zingiberis is packed into add 3 times of amounts of 85% ethanol in the container and stirred once in per 10 minutes ,≤30 ℃ were soaked 5 hours, and leached extracting solution, according to said method extract twice, extracted twice liquid is merged, with distillation under vacuum (≤45 ℃), be concentrated into 1/10-1/15, get the Rhizoma Zingiberis concentrated solution.
(3) Radix Salviae Miltiorrhizae is packed in the container, add 95% ethanol, water bath with thermostatic control≤35 ℃ warm macerating stirred once, soaked 2 hours after 12 hours in per 10 minutes, leach extracting solution, according to said method extract twice, extracted twice liquid is merged, fling to ethanol with atmospheric distillation, be concentrated into 1/10-1/15, obtain the Radix Salviae Miltiorrhizae concentrated solution.
(4) Borneolum Syntheticum is used 95% dissolve with ethanol by 1: 1.5, obtain the pure liquid of ice.
(5) Radix Oenotherae erythrosepalae oil, mixed volatilization oil, concentrated solution 1, concentrated solution 2 are merged with Radix Angelicae Sinensis concentrated solution, Rhizoma Zingiberis concentrated solution, Radix Salviae Miltiorrhizae concentrated solution, the pure liquid of ice, just obtained pharmaceutically active composition concentrated solution of the present invention.
Pharmaceutically active compositions magma and adjuvant combined method are:
(1) with general fiber 4., elastic fibers 6., 7. breast woollen goods buckle, take on that 8. woollen goods are buckled, the elastic force braces 9., the elastic force shoulder belt 10., elastic force back of the body shoulder belt (11) is made into the Wearable vest, promptly gets " accurate vest ".
(2) 1. impermeable backing layer is connected on the casing play, has obtained the skeleton backing layer.
(3) the pharmaceutically active composition concentrated solution is sprayed on the skeleton face of skeleton backing layer; must contain the medicinal liquid casing play 2.; connect controlled release layer 5.; connect upper protective film 3.; wherein the skeleton backing layer is that 30-35%, pharmaceutically active composition concentrated solution are 65-70%; promptly obtained " transdermal administration medicine film " of the present invention, be called for short the medicine film.
(4) the medicine symphysis being connected on the left breast pareordia of accurate vest and breastbone position and left breast lateral surface is left oxter face, promptly obtained " unidirectional transdermal administration medicine film vest " of the present invention, be called for short " unidirectional medicine film vest " and see " Fig. 1 " and " two-way two-dimentional transdermal administration medicine film vest ", be called for short " two-dimentional medicine film vest " and see " Fig. 3 ".
＜embodiment 2〉preparation of externally applied transdermal administration of the present invention " limit sticking type medicine film paste ".
(1) with Radix Oenotherae erythrosepalae oil 1g, Rhizoma Et Radix Notopterygii 8g, Fructus Litseae 7g, Rhizoma Curcumae Longae 6g, Myrrha 6g, equal crushing screening 20-50 order except that Radix Oenotherae erythrosepalae oil.Extract volatile oil with steam distillation respectively, Rhizoma Et Radix Notopterygii volatile oil, Fructus Litseae volatile oil, Rhizoma Curcumae Longae volatile oil, the Myrrha volatile oil that obtains merged the airtight brown bottle of packing into, get mixed volatilization oil, standby, surplus medicinal residues filter is done stand-by.
(2) will filter Rhizoma Et Radix Notopterygii, Fructus Litseae, the Rhizoma Curcumae Longae medicinal residues done and merge in the container of packing into, and add 3 times of amounts of ethanol of 95% ,≤30 ℃ were stirred once after 12 hours in per 10 minutes.Soak and leached extracting solution in 3 hours, extracting solution is incorporated with in the graduated container flings to ethanol, be concentrated into 1/10-1/15, obtain concentrated solution 1 with atmospheric distillation.
(3) will filter the medicinal residues of doing that do not have and pack in the container, and add 3 times of amounts of ethanol of 95% ,≤30 ℃ are soaked after 12 hours and to stir once in per 10 minutes.Soak and leached extracting solution in 3 hours, extracting solution is incorporated with in the graduated container flings to ethanol, be concentrated into 1/10-1/15, obtain concentrated solution 2 with atmospheric distillation.
If also, except that Borneolum Syntheticum, all pulverize 30-60 order sieving for standby with Radix Angelicae Sinensis 5g, Rhizoma Zingiberis 4g, Radix Salviae Miltiorrhizae 4g, Borneolum Syntheticum 2g combination.Its compounding method is:
(1) Radix Angelicae Sinensis is packed into add 3 times of amounts of 85% ethanol in the container and stirred once in per 10 minutes ,≤30 ℃ were soaked 5 hours, and leached extracting solution, according to said method extract twice, extracted twice liquid is merged, with distillation under vacuum (≤45 ℃), be concentrated into 1/10-1/15, get the Radix Angelicae Sinensis concentrated solution.
(2) Rhizoma Zingiberis is packed into add 3 times of amounts of 85% ethanol in the container and stirred once in per 10 minutes ,≤30 ℃ were soaked 5 hours, and leached extracting solution, according to said method extract twice, extracted twice liquid is merged, with distillation under vacuum (≤45 ℃), be concentrated into 1/10-1/15, get the Rhizoma Zingiberis concentrated solution.
(3) Radix Salviae Miltiorrhizae is packed in the container, add 95% ethanol, water bath with thermostatic control≤35 ℃ warm macerating stirred once, soaked 2 hours after 12 hours in per 10 minutes, leach extracting solution, according to said method extract twice, extracted twice liquid is merged, fling to ethanol with atmospheric distillation, be concentrated into 1/10-1/15, obtain the Radix Salviae Miltiorrhizae concentrated solution.
(4) Borneolum Syntheticum is used 95% dissolve with ethanol by 1: 1.5, obtain the pure liquid of ice.
(5) Radix Oenotherae erythrosepalae oil, mixed volatilization oil, concentrated solution 1, concentrated solution 2 are merged with Radix Angelicae Sinensis concentrated solution, Rhizoma Zingiberis concentrated solution, Radix Salviae Miltiorrhizae concentrated solution, the pure liquid of ice, just obtained pharmaceutically active composition concentrated solution of the present invention.
Pharmaceutically active composition concentrated solution and adjuvant combined method: with casing play be divided into 4 parts be connected have pressure-sensitive adhesive layer 3. and area greater than the backing layer of casing play 1. above; spraying pharmaceutically active composition concentrated solution is in the skeleton face; get " containing the medicinal liquid casing play " 2.; connect protecting film 4.; promptly obtain " peripheral stick type transdermal administration medicine film pastes " of the present invention; be called for short " the sticking type medicine film in limit pastes ", see " Fig. 5 ".
＜embodiment 3〉preparation of externally applied transdermal administration of the present invention " sticking type controlled release medicine film paste ".
(1) with Radix Oenotherae erythrosepalae oil 1.5g, Rhizoma Et Radix Notopterygii 9g, Fructus Litseae 8g, Rhizoma Curcumae Longae 7g, Myrrha 7g, except that Radix Oenotherae erythrosepalae oil, all pulverize the 20-50 order, extract volatile oil with steam distillation respectively, the Rhizoma Et Radix Notopterygii volatile oil, Fructus Litseae volatile oil, Rhizoma Curcumae Longae volatile oil, the Myrrha volatile oil that obtain are merged the airtight brown bottle of packing into, get mixed volatilization oil, standby, surplus medicinal residues filter is done stand-by.
(2) will filter Rhizoma Et Radix Notopterygii, Fructus Litseae, the Rhizoma Curcumae Longae medicinal residues done and merge in the container of packing into, and add 3 times of amounts of ethanol of 95% ,≤30 ℃ are soaked after 12 hours and to stir once in per 10 minutes.Soak and leached extracting solution in 3 hours, extracting solution is incorporated with in the graduated container flings to ethanol, be concentrated into 1/10-1/15, obtain concentrated solution 1 with atmospheric distillation.
(3) will filter the medicinal residues of doing that do not have and pack in the container, and add 3 times of amounts of ethanol of 95% ,≤30 ℃ are soaked after 12 hours and to stir once in per 10 minutes.Soak and leached extracting solution in 3 hours, extracting solution is incorporated with in the graduated container flings to ethanol, be concentrated into 1/10-1/15, obtain concentrated solution 2 with atmospheric distillation.
If also, except that Borneolum Syntheticum, all pulverize 30-60 order sieving for standby with Radix Angelicae Sinensis 5g, Rhizoma Zingiberis 4g, Radix Salviae Miltiorrhizae 4g, Borneolum Syntheticum 2g combination.Its preparation method is:
(1) Radix Angelicae Sinensis is packed into add 3 times of amounts of 85% ethanol in the container and stirred once in per 10 minutes ,≤30 ℃ were soaked 5 hours, and leached extracting solution, according to said method extract twice, extracted twice liquid is merged, with distillation under vacuum (≤45 ℃), be concentrated into 1/10-1/15, get the Radix Angelicae Sinensis concentrated solution.
(2) Rhizoma Zingiberis is packed into add 3 times of amounts of 85% ethanol in the container and stirred once in per 10 minutes ,≤30 ℃ were soaked 5 hours, and leached extracting solution, according to said method extract twice, extracted twice liquid is merged, with distillation under vacuum (≤45 ℃), be concentrated into 1/10-1/15, get the Rhizoma Zingiberis concentrated solution.
(3) Radix Salviae Miltiorrhizae is packed in the container, add 95% ethanol, water bath with thermostatic control≤35 ℃ warm macerating stirred once, soaked 2 hours after 12 hours in per 10 minutes, leach extracting solution, according to said method extract twice, extracted twice liquid is merged, fling to ethanol with atmospheric distillation, be concentrated into 1/10-1/15, obtain the Radix Salviae Miltiorrhizae concentrated solution.
(4) Borneolum Syntheticum is used 95% dissolve with ethanol by 1: 1.5, obtain the pure liquid of ice.
(5) Radix Oenotherae erythrosepalae oil, mixed volatilization oil, concentrated solution 1, concentrated solution 2 are merged with Radix Angelicae Sinensis concentrated solution, Rhizoma Zingiberis concentrated solution, Radix Salviae Miltiorrhizae concentrated solution, the pure liquid of ice, just obtained pharmaceutically active composition concentrated solution of the present invention.
The pharmaceutically active composition concentrated solution with the adjuvant combined method is: the pharmaceutically active composition concentrated solution is sprayed on the skeleton face that has been connected impermeable backing layer casing play 1.; get " containing the medicinal liquid casing play " 2.; controlled release layer with holes 5. in the connection; 3. and stick protecting film 4. the adhesive layer of coating the band pressure-sensitive on release-controlled film; " subsides of stick type percutaneous controlled-release administration medicine film " of the present invention have promptly been obtained; be called for short " sticking type controlled release medicine film pastes ", see " Fig. 7-(1), Fig. 7-(2) ".
Claims (10)
1. treat angina pectoris for one kind, medicine film vest, the medicine film of prevention myocardial infarction paste, it is characterized in that it is mainly by following bulk drugs: Radix Oenotherae erythrosepalae oil 1-2 part, Rhizoma Et Radix Notopterygii 8-10 part, Fructus Litseae 7-9 part, Rhizoma Curcumae Longae 6-8 part, Myrrha 6-8 part, make through effective component extracting and adjuvant, it can be obtained by following method.
2. it comprises the following steps: that wherein the consumption of a raw material is 1 part of Radix Oenotherae erythrosepalae oil, 9 parts of Rhizoma Et Radix Notopterygiis, 8 parts of Fructus Litseae, 7.5 parts in Rhizoma Curcumae Longae, 7 parts of Myrrhas medicine according to claim 1,
1. take by weighing each crude drug: except that Radix Oenotherae erythrosepalae oil, all crushing screening 20-50 order is standby:
2. with Rhizoma Et Radix Notopterygii, Fructus Litseae, Rhizoma Curcumae Longae, the Myrrha of described weight proportion, extract volatile oil with steam distillation respectively, with the Rhizoma Et Radix Notopterygii volatile oil, Fructus Litseae volatile oil, Rhizoma Curcumae Longae volatile oil, Myrrha volatile oil, the merging that the obtain airtight brown bottle of packing into, get mixed volatilization oil, standby, surplus medicinal residues filter is done stand-by:
3. will filter Rhizoma Et Radix Notopterygii, Fructus Litseae, the Rhizoma Curcumae Longae medicinal residues done merges in the container of packing into, 3 times of amounts of ethanol of adding 95%, ≤ 30 ℃ are soaked after 12 hours and to stir once in per 10 minutes, soak and leached extracting solution in 3 hours, extracting solution is incorporated with in the graduated container flings to ethanol with atmospheric distillation, be concentrated into 1/10-1/15, obtain concentrated solution 1:
4. will filter the medicinal residues of doing that do not have and pack in the container, and add 3 times of amounts of ethanol of 95% ,≤30 ℃ are soaked after 12 hours and to stir once in per 10 minutes, soak and leached extracting solution in 3 hours, extracting solution is incorporated with in the graduated container, fling to ethanol with atmospheric distillation, be concentrated into 1/10-1/15, obtain concentrated solution 2.
3. also have according to the described wherein crude drug of claim 1: Radix Angelicae Sinensis 2-5 part, Rhizoma Zingiberis 2-4 part, Radix Salviae Miltiorrhizae 2-4 part, Borneolum Syntheticum 0.5-2 part, adjuvant: protecting film, casing play, impermeable backing layer, fibrous layer, controlled release layer, elastic fibers, breast woollen goods buckle, take ons that breast woollen goods are buckled, elastic force shoulder belt, elastic force are carried on the back shoulder belt.
4. it comprises the following steps: according to claim 1,3 described process for preparing medicine
1. take by weighing each crude drug: 3 parts of Radix Angelicae Sinensis, 3 parts of Rhizoma Zingiberiss, 3 parts of Radix Salviae Miltiorrhizaes, 1 part of Borneolum Syntheticum, except that Borneolum Syntheticum, pulverize 30-60 order sieving for standby:
2. the Radix Angelicae Sinensis of described weight proportion is packed into and add 3 times of amounts of ethanol of 85% in the container, stirred once in per 10 minutes, ≤ 30 ℃ were soaked 5 hours, leach extracting solution, according to said method extract twice, extracted twice liquid is merged, with distillation under vacuum (≤45 ℃), be concentrated into 1/10-1/15, get the Radix Angelicae Sinensis concentrated solution:
3. the Rhizoma Zingiberis of described weight proportion is packed into and add 3 times of amounts of ethanol of 85% in the container, stirred once in per 10 minutes, ≤ 30 ℃ were soaked 5 hours, leach extracting solution, according to said method extract twice, extracted twice liquid is merged, with distillation under vacuum (≤45 ℃), be concentrated into 1/10-1/15, get the Rhizoma Zingiberis concentrated solution:
4. Radix Salviae Miltiorrhizae is packed in the container, add 95% ethanol, water bath with thermostatic control≤35 ℃ warm macerating stirred once, soaked 2 hours after 12 hours in per 10 minutes, leach extracting solution, according to said method extract twice, extracted twice liquid is merged, fling to ethanol with atmospheric distillation, be concentrated into 1/10-1/15, obtain the Radix Salviae Miltiorrhizae concentrated solution:
5. Borneolum Syntheticum is used 95% dissolve with ethanol by 1: 1.5, obtains the pure liquid of ice:
6. with Radix Oenotherae erythrosepalae oil, mixed volatilization oil, concentrated solution 1, concentrated solution 2, merge, just obtained pharmaceutically active composition concentrated solution of the present invention with Radix Angelicae Sinensis concentrated solution, Rhizoma Zingiberis concentrated solution, Radix Salviae Miltiorrhizae concentrated solution, the pure liquid of ice.
5. also comprise the following steps: according to claim 1,3,4 described preparation methoies
(1) with general fiber 4., elastic fibers 6., 7. breast woollen goods buckle, take on that 8. woollen goods are buckled, the elastic force braces 9., the elastic force shoulder belt 10., elastic force back of the body shoulder belt (11) is made into the Wearable vest, promptly gets " accurate vest ".
(2) 1. impermeable backing layer is connected on the casing play, has obtained the skeleton backing layer.
6. the pharmaceutically active composition concentrated solution is sprayed on the skeleton face of skeleton backing layer; must contain the medicinal liquid casing play 2.; connect controlled release layer 5.; connect upper protective film 3.; wherein the skeleton backing layer is that 30-35%, pharmaceutically active composition concentrated solution are 65-70%; promptly obtained " transdermal administration medicine film " of the present invention, be called for short the medicine film.
7. also comprise the following steps: the medicine symphysis is connected on the left breast pareordia and the breastbone position of accurate vest according to claim 1,3,5,6 described preparation methoies, promptly obtained " unidirectional transdermal administration medicine film vest " of the present invention, be called for short " unidirectional medicine film vest ", see " Fig. 1 ".
8. comprise the following steps: also that according to claim 1,3,5,6 described preparation methoies it is left oxter portion that the medicine symphysis is connected on the left breast pareordia of accurate vest and breastbone position and left breast outside face, promptly obtained " two-way two-dimentional transdermal administration medicine film vest " of the present invention, be called for short " two-dimentional medicine film vest ", see " Fig. 3 ".
According to claim 1,3,4,5 described preparation methoies also comprise the following steps: with casing play be divided into 4 parts be connected have pressure-sensitive adhesive layer 3. and area greater than the impermeable backing layer of casing play 1. above; spraying pharmaceutically active composition concentrated solution is in the skeleton face; get " containing the medicinal liquid casing play " 2.; connect protecting film 4.; promptly obtained " peripheral stick type transdermal administration medicine film pastes " of the present invention; be called for short " the sticking type medicine film in limit pastes ", see " Fig. 5 ".
10. also comprise the following steps according to claim 1,3,4,5 described preparation methoies; The pharmaceutically active composition concentrated solution is sprayed on the skeleton face that has connected impermeable backing layer casing play 1.; get " containing the medicinal liquid casing play " 2.; controlled release layer with holes 5. in the connection; 3. and stick protecting film 4. the adhesive layer of coating the band pressure-sensitive on release-controlled film; promptly obtained " stick type percutaneous controlled-release administration medicine film " of the present invention; be called for short " sticking type controlled release medicine film pastes ", see " Fig. 7-(1), 7-(2) ".
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| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN200510020384A CN100589794C (en) | 2005-02-21 | 2005-02-21 | Medicinal film vest medicinal film plaster for treating coronary heart disease stenocardia and preventing myocardial infaction and its preparation method |
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| Application Number | Priority Date | Filing Date | Title |
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| CN200510020384A CN100589794C (en) | 2005-02-21 | 2005-02-21 | Medicinal film vest medicinal film plaster for treating coronary heart disease stenocardia and preventing myocardial infaction and its preparation method |
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Cited By (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN104435378A (en) * | 2014-09-19 | 2015-03-25 | 赵春梅 | Protective vest for wearing of critical patients and production method thereof |
| CN106307710A (en) * | 2016-09-24 | 2017-01-11 | 防城港市港口区思达电子科技有限公司 | Traditional Chinese medicine sterilization mask |
| CN106360844A (en) * | 2016-09-24 | 2017-02-01 | 防城港市港口区思达电子科技有限公司 | Traditional Chinese medicine refreshing mask |
-
2005
- 2005-02-21 CN CN200510020384A patent/CN100589794C/en not_active Expired - Fee Related
Cited By (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN104435378A (en) * | 2014-09-19 | 2015-03-25 | 赵春梅 | Protective vest for wearing of critical patients and production method thereof |
| CN106307710A (en) * | 2016-09-24 | 2017-01-11 | 防城港市港口区思达电子科技有限公司 | Traditional Chinese medicine sterilization mask |
| CN106360844A (en) * | 2016-09-24 | 2017-02-01 | 防城港市港口区思达电子科技有限公司 | Traditional Chinese medicine refreshing mask |
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| CN100589794C (en) | 2010-02-17 |
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