CN1824084A - Active component extraction method of plant polyphenol kind substance - Google Patents
Active component extraction method of plant polyphenol kind substance Download PDFInfo
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- CN1824084A CN1824084A CN 200510022420 CN200510022420A CN1824084A CN 1824084 A CN1824084 A CN 1824084A CN 200510022420 CN200510022420 CN 200510022420 CN 200510022420 A CN200510022420 A CN 200510022420A CN 1824084 A CN1824084 A CN 1824084A
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Abstract
A process for extracting the active polyphenol substances from the natural plants includes such steps as washing, drying, pulverizing, loading it along with the deoxidizing purified water in an extractor, heating at 50-90 deg.C under the protection of inertial gas while stirring for 30-60 min in order to extract the active components or ultrasonic or microwave extracting for 10-40 min 1-5 times, collecting liquid extract, filtering, cooling concentrating and drying.
Description
One, technical field
The present invention belongs to the natural product extraction manufacture field about the active extracting method of plant polyphenol.
Two, background technology
Folium Camelliae sinensis, Semen Vitis viniferae and natural plant Fructus Chebulae, GAMBIER, Radix Et Rhizoma Rhei, Cortex Moutan, Herba Agrimoniae, Rhizoma Osmundae, Herba Erodii, white peony root etc. all have been rich in plant polyphenol.Modern scientific research shows, plant polyphenol is not only a kind of natural nontoxic antioxidant, and be a kind of ideal natural drug, has biological activitys such as removing free radical and antioxidation, in antibacterial, antiviral, cancer-resisting, inhibition tumor, prevent and treat aspect such as cardiovascular disease and have good efficacy.
The production and selling of plant polyphenol is the history of existing more than ten years at home and abroad, and the plant polyphenol product is mainly used in the following aspects at present: antitumor drug; The cardiovascular health medicine; Anti-diabetic and obesity health care medicine; Anti-virus formulation; Cosmetics; The food oxydating resistance additive; Oral cleaner; Beverage; Antistaling agent; Color preserving agent; Deodorizer etc.
The production method of plant polyphenol is numerous, mainly contains solvent method, the sedimentation method and absorption method.No matter adopt any method to extract, solvent extraction is its processing step that must adopt.Because plant polyphenol is the material of a class poor heat stability, easy oxidized losing activity in leaching process, " the active extracting method of plant polyphenol " then takes effective measures, avoid the oxidation of plant polyphenol in leaching process, can significantly improve the plant polyphenol product activity.Therefore, " the active extracting method of plant polyphenol " is the important technology to the plant polyphenol development and utilization, do not see relevant report so far yet.
Three, summary of the invention
The objective of the invention is at the deficiencies in the prior art, and the active extracting method of a kind of natural plants polyphenols that provides.Be characterized in adopting the extractant that removed oxygen and under inert gas shielding, avoid the Oxidation of plant polyphenol in leaching process, improve the plant polyphenol product activity.
Purpose of the present invention is realized that by following technical measures wherein said raw material umber is parts by weight except that specified otherwise.
The active extracting method of plant polyphenol contains following steps:
1. the activity of plant polyphenol is extracted
The natural material of plant polyphenol will be rich in; through clean, dry, pulverize, take by weighing after the pulverizing raw material 1-4 part and with vacuum pump or charge into pure water 5-10 part that noble gas removes dissolved oxygen, join in the extractor; under inert gas shielding; extracted 30-60 minute in temperature 50-90 ℃ of insulated and stirred, filter, get the active plant polyphenols extracting solution; repeat 1-5 time; merge extractive liquid, is through concentrating back, dry, acquisition active plant polyphenol solids.Or
2. the activity of plant polyphenol is extracted
To be rich in the natural material of plant polyphenol through cleaning, dry, pulverizing; take by weighing after the pulverizing raw material 1-4 part and with vacuum pump or charge into pure water 5-10 part that noble gas removes dissolved oxygen; join in the extractor, under inert gas shielding, with ultrasound wave or microwave extraction 10-40 minute; filter; get the active plant polyphenols extracting solution, repeat merge extractive liquid, 1-5 time; through concentrating back, dry, acquisition active plant polyphenol solids.
The natural material of plant polyphenol is any in Folium Camelliae sinensis, Semen Vitis viniferae, Fructus Chebulae, GAMBIER, Radix Et Rhizoma Rhei, Cortex Moutan, Herba Agrimoniae, Rhizoma Osmundae, Herba Erodii, white peony root, Radix Notoginseng and the Folium Hibisci Mutabilis.
Frequency of ultrasonic is 50～500Hz, and power is 100～2000W.
Microwave frequency is 50～100Hz, and power is 500～2000W.
The present invention has following advantage:
1. adopt the extractant and the inert media resist technology that remove dissolved oxygen, avoided the oxidation reaction of plant polyphenol in leaching process, improved the plant polyphenol product activity.
2. under than the low normal temperature condition of the extraction temperature of existing technology, adopt ultrasound wave or microwave technology to extract, avoided the influence of heating, also reduced the energy consumption of the generation of heating required steam simultaneously plant polyphenol stability.
3. under normal temperature condition, adopt ultrasound wave or microwave technology to extract, shortened extraction time, improved extraction efficiency, also reduced plant polyphenol ruined probability in solvent simultaneously.
4. not with an organic solvent, do not change the solution pH value.
5. whole technology does not have the three wastes and produces, and is eco-friendly friendly process.
Four, the specific embodiment
Below by embodiment the present invention is carried out concrete description; be necessary to point out that at this following examples only are used for the present invention is further detailed; but can not be interpreted as limiting the scope of the invention, the person skilled in the art in this field can make some nonessential improvement and adjustment according to the content of the invention described above.
Embodiment 1:
Folium Camelliae sinensis or the dust removal of Folium Camelliae sinensis garbage are purified, dry, pulverized 100 μ m; Take by weighing Folium Camelliae sinensis powder 100 gram, with vacuum pump or charge into nitrogen or the noble gas of argon or helium removes pure water 500 grams of dissolved oxygen, join in the extractor with; Under protection of nitrogen gas, be warming up to 60 ℃, stir to extract 30 minutes, filter, the actived tea polyphenols extracting solution, repeats 3 times, merge extractive liquid,, after concentrated, dry, acquisition actived tea polyphenols solids.
Embodiment 2:
Folium Camelliae sinensis or the dust removal of Folium Camelliae sinensis garbage are purified, dry, pulverized 200 μ m; Take by weighing Folium Camelliae sinensis powder 200 gram, with vacuum pump or charge into nitrogen or the noble gas of argon or helium removes pure water 600 grams of dissolved oxygen, join in the microwave extraction device with; Under protection of nitrogen gas, microwave extraction 20 minutes, microwave frequency 50Hz, power 1500W filters, the actived tea polyphenols extracting solution, repeats 3 times, merge extractive liquid,, after concentrated, dry, acquisition actived tea polyphenols solids.
Embodiment 3:
Folium Camelliae sinensis or the dust removal of Folium Camelliae sinensis garbage are purified, dry, pulverized 400 μ m; Take by weighing Folium Camelliae sinensis powder 200 gram, with vacuum pump or charge into nitrogen or the noble gas of argon or helium removes pure water 600 grams of dissolved oxygen, join in the ultrasonic extraction device with; Under protection of nitrogen gas, ultrasonic extraction 20 minutes, ultrasonic frequency 50Hz, power 2000W filters, the actived tea polyphenols extracting solution, repeats 3 times, merge extractive liquid,, after concentrated, dry, acquisition actived tea polyphenols solids.
Embodiment 4:
The Semen Vitis viniferae dust removal is purified, dry, pulverized 600 μ m; Take by weighing Semen Vitis viniferae powder 400 gram, with vacuum pump or charge into nitrogen or the noble gas of argon or helium removes pure water 1000 grams of dissolved oxygen, join in the extractor with; Under protection of nitrogen gas, be warming up to 90 ℃, stir to extract 60 minutes, filter, active grape seed polyphenols extracting solution, repeats 3 times, merge extractive liquid, after concentrated, dry, obtains active grape seed polyphenols solids.
Embodiment 5:
The Semen Vitis viniferae dust removal is purified, dry, pulverized 800 μ m; Take by weighing Semen Vitis viniferae powder 400 gram, with vacuum pump or charge into nitrogen or the noble gas of argon or helium removes pure water 1000 grams of dissolved oxygen, join in the extractor with; Under protection of nitrogen gas, microwave extraction 20 minutes, microwave frequency 50Hz, power 2000W filters, active grape seed polyphenols extracting solution, repeats 3 times, merge extractive liquid, after concentrated, dry, obtains active grape seed polyphenols solids.
Embodiment 6:
The Semen Vitis viniferae dust removal is purified, dry, pulverized 1000 μ m; Take by weighing Semen Vitis viniferae powder 400 gram, with vacuum pump or charge into nitrogen or the noble gas of argon or helium removes pure water 2000 grams of dissolved oxygen, join in the extractor with; Under protection of nitrogen gas, ultrasonic extraction 20 minutes, ultrasonic frequency 500Hz, power 2000W filters, active grape seed polyphenols extracting solution, repeats 3 times, merge extractive liquid, after concentrated, dry, obtains active grape seed polyphenols solids.
Embodiment 7:
The Fructus Chebulae dust removal is purified, dry, pulverized 1500 μ m; Take by weighing Fructus Chebulae powder 300 gram, with vacuum pump or charge into nitrogen or the noble gas of argon or helium removes pure water 800 grams of dissolved oxygen, join in the extractor with; Under protection of nitrogen gas, be warming up to 80 ℃, stir to extract 50 minutes, filter, active chebulic acid extracting solution, repeats 3 times, merge extractive liquid, after concentrated, dry, obtains active chebulic acid polyphenol solids.
Embodiment 8:
The GAMBIER dust removal is purified, dry, pulverized 1800 μ m; Take by weighing GAMBIER powder 200 gram, with vacuum pump or charge into nitrogen or the noble gas of argon or helium removes pure water 700 grams of dissolved oxygen, join in the extractor, with the pure water that has taken off dissolved oxygen with; Under protection of nitrogen gas, be warming up to 60 ℃, stir to extract 40 minutes, filter, the active component extracting solution, repeats 3 times, merge extractive liquid, after concentrated, dry, obtains active GAMBIER polyphenol solids.
Embodiment 9:
The Cortex Moutan dust removal is purified, dry, pulverized 2000 μ m; Take by weighing Paeonia suffruticosa corium farinosum 200 gram, with vacuum pump or charge into nitrogen or the noble gas of argon or helium removes pure water 700 grams of dissolved oxygen, join in the extractor with; Under protection of nitrogen gas, be warming up to 60 ℃, stir to extract 40 minutes, filter, the active component extracting solution, repeats 3 times, merge extractive liquid, after concentrated, dry, obtains active Cortex Moutan polyphenol solids.
Embodiment 10:
The Herba Agrimoniae dust removal is purified, dry, pulverized 1800 μ m; Take by weighing red crowned crane grass meal 100 gram, with vacuum pump or charge into nitrogen or the noble gas of argon or helium removes pure water 500 grams of dissolved oxygen, join in the ultrasonic extraction device with; Ultrasonic extraction is 10 minutes under protection of nitrogen gas, ultrasonic frequency 100Hz, power 1000W filters, the active component extracting solution, repeats 3 times, merge extractive liquid, after concentrated, dry, obtains active Herba Agrimoniae polyphenol solids.
Embodiment 11:
The Rhizoma Osmundae dust removal is purified, dry, pulverized 423 μ m; Take by weighing Rhizoma Osmundae powder 300 gram, with vacuum pump or charge into nitrogen or the noble gas of argon or helium removes pure water 700 grams of dissolved oxygen, join in the ultrasonic extraction device with; Under protection of nitrogen gas, ultrasonic extraction 30 minutes, ultrasonic frequency 200Hz, power 1500W filters, the active component extracting solution, repeats 3 times, merge extractive liquid, after concentrated, dry, obtains active Rhizoma Osmundae polyphenol solids.
Embodiment 12:
The Herba Erodii dust removal is purified, dry, pulverized 600 μ m and take by weighing Herba Erodii powder 200 grams, with vacuum pump or charge into nitrogen or the noble gas of argon or helium removes pure water 600 grams of dissolved oxygen, join in the microwave extraction device with; Under protection of nitrogen gas, microwave extraction 20 minutes, microwave frequency 50Hz, power 500W filters, the active component extracting solution, repeats 3 times, merge extractive liquid, after concentrated, dry, obtains active geranium polyphenol solids.
Embodiment 13:
Radix Paeoniae Alba dust removal is purified, dry, pulverized 800 μ m; Take by weighing Radix Paeoniae Alba powder 200 gram, with vacuum pump or charge into nitrogen or the noble gas of argon or helium removes pure water 600 grams of dissolved oxygen, join in the ultrasonic extraction device with; Under protection of nitrogen gas, ultrasonic extraction 20 minutes, ultrasonic frequency 300Hz, power 100W filters, the active component extracting solution, repeats 3 times, merge extractive liquid, after concentrated, dry, obtains active Radix Paeoniae Alba polyphenol solids.
Embodiment 14:
The Radix Notoginseng dust removal is purified, dry, pulverized 1000 μ m; Take by weighing Radix Notoginseng powder 400 gram, with vacuum pump or charge into nitrogen or the noble gas of argon or helium removes pure water 500 grams of dissolved oxygen, join in the microwave extraction device with; Under protection of nitrogen gas, microwave extraction 40 minutes, microwave frequency 100Hz, power 500W filters, the active component extracting solution, repeats 3 times, merge extractive liquid,, after concentrated, dry, acquisition Active pseudo-ginseng polyphenol solids.
Embodiment 15:
The Folium Hibisci Mutabilis dust removal is purified, dry, pulverized 1500 μ m; Take by weighing Folium Hibisci Mutabilis powder 100 gram, with vacuum pump or charge into nitrogen or the noble gas of argon or helium removes pure water 1000 grams of dissolved oxygen, join in the ultrasonic extraction device with; Under protection of nitrogen gas, ultrasonic extraction 40 minutes, ultrasonic frequency 400Hz, power 200W filters, the active component extracting solution, repeats 3 times, merge extractive liquid, after concentrated, dry, obtains active Folium Hibisci Mutabilis polyphenol solids.
Claims (5)
1. the active extracting method of a plant polyphenol is characterized in that this method contains following steps:
The natural material of plant polyphenol will be rich in; through clean, dry, pulverize, take by weighing after the pulverizing raw material 1-4 weight portion and with vacuum pump or charge into the pure water 5-10 weight portion that noble gas removes dissolved oxygen, join in the extractor; under inert gas shielding; extracted 30-60 minute in temperature 50-90 ℃ of insulated and stirred, filter, get the active plant polyphenols extracting solution; repeat 1-5 time; merge extractive liquid, is through concentrating back, dry, acquisition active plant polyphenol solids.
2. the active extracting method of a plant polyphenol is characterized in that this method contains following steps:
The natural material of plant polyphenol will be rich in; through clean, dry, pulverize, take by weighing after the pulverizing raw material 1-4 weight portion and with vacuum pump or charge into the pure water 5-10 weight portion that noble gas removes dissolved oxygen, join in the extractor; under inert gas shielding; with ultrasound wave or microwave extraction 10-40 minute, filter, the active plant polyphenols extracting solution; repeat 1-5 time; merge extractive liquid, is through concentrating back, dry, acquisition active plant polyphenol solids.
3. the active extracting method of plant polyphenol according to claim 1, the natural material that it is characterized in that being rich in plant polyphenol are any in Folium Camelliae sinensis, Semen Vitis viniferae, Fructus Chebulae, GAMBIER, Radix Et Rhizoma Rhei, Cortex Moutan, Herba Agrimoniae, Rhizoma Osmundae, Herba Erodii, white peony root, Radix Notoginseng or the Folium Hibisci Mutabilis.
4. the active extracting method of plant polyphenol according to claim 1 is characterized in that frequency of ultrasonic is 50～500Hz, and power is 100～2000W.
5. the active extracting method of plant polyphenol as claimed in claim 1 or 2 is characterized in that microwave frequency 50～100Hz, power 500～2000W.
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| CN101294048B (en) * | 2008-06-19 | 2010-06-23 | 晋城市柿宝科技发展有限公司 | Method for preparing persimmon tannin extract |
| CN1970015B (en) * | 2006-12-12 | 2010-09-22 | 中国人民解放军第三军医大学 | Enzymatic extraction method of pawpaw polyphenol |
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| CN1970015B (en) * | 2006-12-12 | 2010-09-22 | 中国人民解放军第三军医大学 | Enzymatic extraction method of pawpaw polyphenol |
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| FR2926190A1 (en) * | 2008-01-14 | 2009-07-17 | Thiomed Soc Par Actions Simpli | PROCESS FOR PREPARING PLANT EXTRACTS FOR OBTAINING A NEW GALENIC FORM |
| CN101294048B (en) * | 2008-06-19 | 2010-06-23 | 晋城市柿宝科技发展有限公司 | Method for preparing persimmon tannin extract |
| CN101444562B (en) * | 2008-12-24 | 2012-10-03 | 中国人民解放军第三军医大学 | Papaya anti-oxidant serum and preparation method thereof |
| CN101773589B (en) * | 2010-01-12 | 2011-08-17 | 海南大学 | Production method of coconut polyphenol extracts |
| CN103622135A (en) * | 2013-11-26 | 2014-03-12 | 山东鲁花集团有限公司 | Method for extracting polyphenols from peanut skins |
| CN105146590B (en) * | 2015-09-08 | 2019-04-12 | 浙江省海洋开发研究院 | A kind of preparation method of canned tunas |
| CN105146590A (en) * | 2015-09-08 | 2015-12-16 | 浙江省海洋开发研究院 | Preparation method for canned tuna |
| CN105237589A (en) * | 2015-11-04 | 2016-01-13 | 中国科学院过程工程研究所 | Method for simultaneously extracting polyphenol and hemicellulose in grape pips |
| CN105535029A (en) * | 2015-12-28 | 2016-05-04 | 江苏大学 | Countercurrent ultrasonic preparation method of propolis extract |
| CN105535029B (en) * | 2015-12-28 | 2020-02-21 | 江苏大学 | Countercurrent ultrasonic preparation method of propolis extract |
| CN105853475A (en) * | 2016-01-05 | 2016-08-17 | 浙江海洋学院 | Preparation method of pemphis acidula extract |
| CN105779588A (en) * | 2016-01-28 | 2016-07-20 | 云南农业大学 | Detection method of inducing plant immune responses by virtue of tobacco polyphenols |
| CN109054014A (en) * | 2018-07-24 | 2018-12-21 | 上海中医药大学 | A kind of polyphenol polymer and application thereof |
| CN109054014B (en) * | 2018-07-24 | 2020-06-26 | 上海中医药大学 | Polyphenol polymer and application thereof |
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| CN100372556C (en) | 2008-03-05 |
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Assignee: Guangzhou Xipu Biotic Feedstuff Co., Ltd. Assignor: Xie Jun Contract fulfillment period: 2009.6.30 to 2015.6.29 contract change Contract record no.: 2009440001295 Denomination of invention: Active component extraction method of plant polyphenol kind substance Granted publication date: 20080305 License type: Exclusive license Record date: 2009.8.20 |
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