CN1814274A - Health-care product for treating cardiovascular and cerebralvascular disease - Google Patents
Health-care product for treating cardiovascular and cerebralvascular disease Download PDFInfo
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Abstract
The invention relates to a health care product for cardiovascular diseases and cerebrovascular disease that is made up from Se rich yeast, chelate type asparagic acid Ca, chelate type asparagic acid Mg, chelate type glycine Zn, L-asparagic acid K, folic acid, linolenic acid dried powder, bean frozen dried powder, ginkgo leaf extract, fresh ginger extract, celery extract, rhodiola root extract, and valerian extract. The invention supplies a health cure product that has comprehensive nutrient content and has prevent and cure effect for cardiovascular diseases and cerebrovascular disease.
Description
Technical field
A kind of health product that are used for cardiovascular and cerebrovascular disease relate to field of health care products.
Background technology
Since modern way of life, growth in the living standard and life-time dilatation, and the incidence rate and the case fatality rate of cardiovascular and cerebrovascular disease increase day by day, have become the No.1 killer of human diseases.The annual in the world at present cardiovascular and cerebrovascular disease that has 800～1,000 ten thousand people to die from arteriosclerosis and cause.In the incidence and mortality that U.S.'s various diseases constitutes, it is the first that thrombotic disease occupy, and its mortality rate is also higher 5 times than cancer.In China, the hyperpietic has reached 1.1～1.3 hundred million at present; It is younger that evidence of coronary heart diseases is tending towards, and the mortality rate of coronary heart disease is up to 62%; It is younger that the age of onset of apoplexy also is tending towards, and the patient of the right side of fifty reaches 12%.
There are 1.2 hundred million hyperpietics in the whole nation now, accounts for 8% of total population.China causes the patient of apoplexy to have 1,500,000 by hypertension every year, and mortality rate occupies the second place of the world; Cause the people of coronary heart disease to have 230 ten thousand by hypertension every year.
Coronary heart disease is whole world sickness rate, the primary disease of mortality rate.In China, 1957～1978, evidence of coronary heart diseases has only 1.6%, and present sickness rate is 6.5%, has increased by 4 times.Statistics China dies from the number of acute myocardial infarction above 1,000,000 at present.
Coronary heart disease " youth " 15 years old at least in China.The cardiovascular and cerebrovascular vessel Epidemiological study has been carried out to 700,000 people in Beijing in 10 years, find that in 45 years old～59 years old crowd, coronary heart disease has increased by 50% (male), and 32% (women), minimus myocardial infarction patient just just 30 have lifted one's head.
Along with propagating its belief on a large scale of " modern civilization diseases " such as cardiovascular and cerebrovascular diseases, the human step of struggling of never stopping with it.From the application of Chinese medicine, to Drug therapy, the operative treatment of western medicine, the means of human protection heart are more and more.
The trend along with " Drug abuse " occurs, it is found that incident side effect is also more and more obvious, united states drug Surveillance Authority (FDA) statistical data shows: the people the inside at all Died Of Diseases has 1/7 to be the toxic and side effects of dying from medicine, rather than dies from disease itself.Understand the side effect of cardiovascular and cerebrovascular diseases medicament, to the help of correctly taking medicine and being necessary:
1., diuretic.As hydrochlorothiazide.Because it influences insulin metabolism, hypertension complicated with diabetes mellitus the person do not use.
2., beta-blocker.As: metoprolol, metoprolol.This class medicine can not only blood pressure lowering, can also decreased heart rate, reduce and orthosympatheticly be overexcited, and therefore can cause delayed ischemic neurological deficits, increase the weight of abnormal carbohydrate metabolism, cause or increase the weight of diabetes.Since can decreased heart rate, for the slow patient of heart beating, will SC in the time of use.In addition, if patient has the disease of respiratory tract, also be noted that because this class medicine may produce spasm to organ.
3., calcium ion antagonist.As: nifedipine (nifedipine), amlodipine (Norvasc).Can influence insulin metabolism.Can cause headache, edema of lower limbs.
4., alpha blocker.As: terazosin (hytrin).A shortcoming is often arranged, may produce hypotension, perhaps postural hypotension is careful in the time of use.
5., angiotensin converting enzyme inhibitor.As: captopril, cilazapril, benazepril.The curative effect of this class medicine is more definite, is adapted to hypertension especially, diabetes are arranged, the patient of renal insufficiency is arranged.But this class medicine has side effect such as the patient of causing coughs, and therefore the patient of obvious cough is arranged, and will use other medicine instead.
Summary of the invention
An object of the present invention is to solving the medicine or the health product side effect that are used for cardiovascular and cerebrovascular disease in the above-mentioned prior art big, act on single problem, provide a kind of nutritional labeling comprehensive, the effect that has prevention and adjuvant treatment effect concurrently is used for the health product of cardiovascular and cerebrovascular disease significantly.
Another object of the present invention provides a kind of preparation method that is used for the health product of cardiovascular and cerebrovascular disease.
For achieving the above object, a technical scheme of the present invention provides a kind of health product that are used for cardiovascular and cerebrovascular disease, and the health product that originally are used for cardiovascular and cerebrovascular disease are formulated according to parts by weight by following raw material: yeast rich in selenium 15-35 part; Chelating type calcium aminosuccinic acid 100-200 part; Chelating type Aspartic acid magnesium 100-200 part; Chelating type zinc glycinate 10-30 part; L-Aspartic acid potassium 200-400 part; Folic acid 0.01-1 part; Linolenic acid dry powder 15-35 part; Natto lyophilized powder 50-150 part; Folium Ginkgo extract 40-60 part; Rhizoma Zingiberis Recens extract 20-80 part; Herba Apii graveolentis extract 50-150 part; Radix Rhodiolae extract 40-60 part; Rhizoma et radix valerianae extract 40-60 part;
The optimization formula that the present invention is used for the health product of cardiovascular and cerebrovascular disease is: yeast rich in selenium 20-30 part; Chelating type calcium aminosuccinic acid 120-180 part; Chelating type Aspartic acid magnesium 120-180 part; Chelating type zinc glycinate 15-25 part; L-Aspartic acid potassium 250-350 part; Folic acid 0.05-0.2 part; Linolenic acid dry powder 20-30 part; Natto lyophilized powder 80-120 part; Folium Ginkgo extract 45-55 part; Rhizoma Zingiberis Recens extract 40-60 part; Herba Apii graveolentis extract 80-120 part; Radix Rhodiolae extract 45-55 part; Rhizoma et radix valerianae extract 45-55 part;
The more preferably prescription that the present invention is used for the health product of cardiovascular and cerebrovascular disease is:
25 parts of yeast rich in seleniums; 150 parts of chelating type calcium aminosuccinic acids; 150 parts of chelating type Aspartic acid magnesiums; 20 parts of chelating type zinc glycinate; 300 parts of L-Aspartic acid potassiums; 0.15 part in folic acid; 25 parts in linolenic acid dry powder; 90 parts of natto lyophilized powder; 50 parts of Folium Ginkgo extract; 50 parts of Rhizoma Zingiberis Recens extracts; 100 parts of Herba Apii graveolentis extract; 50 parts of Radix Rhodiolae extracts; 50 parts of Rhizoma et radix valerianae extracts;
Can also add adjuvant 100-150 part in the above-mentioned raw materials, be beneficial to making of tablet.Adjuvant comprises microcrystalline Cellulose, magnesium stearate, dextrin, and be 70 parts with ratio of weight and number: 10 parts: 20 parts ratio is formulated; Preferred 130 parts of adjuvant.
Another technical scheme of the present invention provides a kind of preparation method that is used for the health product of cardiovascular and cerebrovascular disease, and concrete steps are as follows:
1, raw material and ingredient powder are broken to 80～200 orders;
2, above-mentioned raw materials and adjuvant are placed mixing tank jointly, fully mixing;
3, in tablet machine, feed intake, tabletting;
Beneficial effect
Beneficial effect of the present invention is:
1, embodied the newest research results of modern nutriology, the present invention carries out specific aim according to the nutrient that lacks among the cardiovascular and cerebrovascular vessel invalid diet and replenishes:
Potassium K: adopting chelating amino acids potassium is raw material.Potassium element is kept the normal function of cardiac muscle, brings high blood pressure down.The diet of the low potassium of high sodium causes hypertension easily, replenishes high potassium food, and is favourable to prophylaxis of hypertension.
Calcium Ca: the employing calcium amino acid chelate is a raw material.Low calcium is risk factors for hypertension.In the body fluid, calcium ion and potassium, magnesium, sodium plasma are kept normally beating of nervimuscular NE, heart jointly.
Magnesium Mg: the employing magnesium amino acid chelate is a raw material.Magnesium deficiency and cardiovascular and cerebrovascular disease are closely related, as premature beat, atrial fibrillation, atherosclerosis, hypertension.Mg supplementation from food has protective effect to cardiac muscle, can prevent and treat myocardial infarction.
Zinc Zn: the employing zinc-amino acid chelate is a raw material.Zinc is the constituent of plurality of enzymes, and known zinciferous enzyme has kind more than 200, and these enzymes have important effect to keeping the human body normal physiological function.Zinc can be regulated and control the secretion and the generation of human immunity regulatory factor simultaneously, to guaranteeing immune integrity crucial effect is arranged.
Selenium Se: the employing yeast rich in selenium is a raw material, is good organic selenium source.Selenium has important protective effect to myocardial cell, arteriolar 26S Proteasome Structure and Function.Myocardial function is impaired when lacking selenium.The most of area of China lacks selenium, and Beijing, Shanghai belong to moderate and lacks the selenium area.
Linolenic acid: the linolenic natural wild plant Cortex Eucommiae is rich in employing, Folium Perillae is a raw material, extracts linolenic acid dry powder, and content is up to 80%.The preliminary study of Boston University's medical college shows that fatty low-down diet itself may trigger heart disease; They find that topmost risk factor is because not enough to two kinds " polyunsaturated fatty acid " picked-up of human nutrition necessity.Ω-3 unsaturated fatty acid refers to linolenic acid (alpha linolenic acid, acid and gamma-linolenic), they are the constituent of cell membrane, are the requisite materials of brain and nervous system, immune system, cardiovascular system and skin, play an important role in preventing and treating coronary heart disease, hypertension, arteriosclerosis.U.S. FDA is recommended: must replenish alpha linolenic acid every day.
Folic acid: vitamin B group class." homocysteine " will be too high in scarce VB (folic acid, B6, the B12) blood, and this thing can make the blood vessel wall breakage, becomes rough, causes the precipitation of cholesterol easily, causes platelet aggregation.The coronary heart disease that causes thus causes the dangerous high 3 times of coronary heart disease than cholesterol! Folic acid can make the dangerous substance " homocysteine " that causes coronary heart disease be converted into methionine, prevents and treats coronary heart disease.
2, inherit the valuable practical experience of dietetic therapy science, the present invention adopts the natural plants with food therapy effect, the concentration extraction effective ingredient:
Folium Ginkgo extract: China announces that Folium Ginkgo is written into as official drug, has established the marvellous status of its official drug in formal 2000 version " pharmacopeia " carrying out.Call it: nature and flavor are sweet, bitter, puckery, flat, the GUIXIN lung meridian, and function is astringed the lung, is relievingd asthma, blood circulation promoting and blood stasis dispelling, pain relieving, is used for cough and asthma due to lung deficiency, coronary heart disease, angina pectoris, hyperlipidemia.
A large amount of The pharmacological results shows, has the composition of valuable pharmacological active function that two big classes are arranged in the Folium Ginkgo: ginkgo flavonoid glycoside and Folium Ginkgo terpene lactones.Their peculiar mechanism of action are inequality with the cardiovascular and cerebrovascular diseases medicine of using always more clinically at present.
First Folium Ginkgo terpene lactones is optionally resisted platelet activating factor.Platelet activating factor PAF is a kind of very strong caused platelet aggregation and a thrombosed endogenous active substance in the human body, is to bring out the remorse disease of cardiovascular and cerebrovascular vessel, particularly causes the stealthy killer of apoplexy, myocardial infarction, and danger is very high.Platelet activating factor RAF can cause inflammation, shock, bronchoconstriction and gastric ulcer etc.PAF also can cause asthma, organ transplant rejection, myocarditis Secondary cases arrhythmia, vasculitis etc.Folium Ginkgo terpene lactones then is the jinx of platelet activating factor.
It two is that ginkgo flavonoid glycoside has the high-strength ability that tackles free radical.Ginkgo flavonoid glycoside has been proved and can have resisted and eliminate free radical effectively, and plays the good action of slow down aging.Particularly, think that Folium Ginkgo can be used for prevention and cures the early senile dementia patient in the recent period from external information, obvious to helping recovery and improving the memory effect especially.
It three is that Folium Ginkgo terpene lactones and flavonoid glycoside have synergism, and expansible blood vessel, blood flow increasing improve cardiovascular and cerebrovascular circulation, under anaerobic conditions protect brain and myocardial cell.Can reduce triglyceride in the blood in addition, and improve hdl concentration, improve the activity of erythrocyte superoxide dismutase.So the preparation of Folium Ginkgo extract all has comparatively favorable effects to patients such as coronary heart disease, angina pectoris, hyperlipidemia and cerebral concussion, cerebral trauma sequelas, and general rarely untoward reaction occurs, easily be people's acceptance as health medicine.
Because old and feeble, the trick blood supply insufficiency often appears in middle-aged and elderly people.Cause Raynaud disease, intermittent claudication (blood supply insufficiency causes myalgia), numb limbs and tense tendons and twinge.And Semen Ginkgo can promote blood circulation, and countless studies show that, Semen Ginkgo was to thinking before that the many disturbance of circulation miscellaneous diseases that can't cure had tangible clinical efficacy.
Semen Ginkgo protection brain cell is because its blood circulation promoting strengthens the oxygen of pair cell and the conveying of glucose.In aging all relevant diseases, senile dementia is the most fearful a kind of.Senile dementia is meant that the function in brain control reasoning and memory district can't continue to worsen with changing.Along with PD, unfortunate patient and household's life become at sixes and sevens.The death of neurocyte causes ability degeneration, cognitive power disappearance, judgment weakening, disorientation, the personality changes of all execution routine works, also has linguistic competence's forfeiture etc.There is 4,000,000-6,000,000 American that senile dementia is arranged approximately.Along with the aging of population, estimate that this number can reach 14,000,000 before the year two thousand twenty.Semen Ginkgo is improved the brain local blood circulation, strengthens neurokyme mediator ability, and improving memory and cerebral function improvement has good result, so the new purposes of the very good Semen Ginkgo goods of medical expert.Because the Semen Ginkgo goods are fool proof to human body, do not see the toxic side effect report, so expert advice: patients of senile dementia can be taken the Semen Ginkgo goods for a long time, is beneficial to improve cognitive competence, prevents cerebral neural degeneration.
Natto lyophilized powder: natto is the national food of tool Japan characteristic, in Japan history more than thousand is arranged.Natto is a kind of snack food that Semen Glycines is made by fermentation.The edible for a long time natto of 90% Japanese family.Natto makes Japanese health status obtain bigger improvement.
Scientist's research finds that also natto is that minority can thrombolytic food in 230 kinds of food.In Japan, natto is called as " most valuable treasure natto ", is decided to be the natto joint annual July 10.
Japan is world-class long-lived country, and women's average life is 87.6 years old, occupies first place in the world.By the end of the year 2002, the long lived elder of Japan above 100 years old records high again, reaches 17934 people, increases by 2459 than calendar year 2001 and goes into sustainable growth in continuous 32 years.
Discover the efficient thrombolytic of nattokinase energy that contains in the natto, the embolism class diseases of multiple cardiovascular and cerebrovascular vessel such as control cerebral thrombosis, hypertension, hyperlipidemia, cerebral infarction, apoplexy, coronary heart disease.
Nattokinase (Natto Kiansw NK) is material in the Japanese Natto, is a kind of small protein, can be by intestinal absorption, can thrombus, and thrombolysis activity is four times of fibrinolysin plasmin in the body of NK.1980, must see that the doctor of medicine of foreign firm has the material of stronger thrombolytic effect in Chicago,U.S discovery natto, and this new effective ingredient, called after " nattokinase ".
Japan holy Mariana medical university difficult disease treatment research center and Japanese bioscience institute find that the effect that nattokinase has the inhibition platelet to solidify helps prophylaxis of hypertension and arteriosclerosis.
Natto can also prophylaxis of hypertension.In the stickum around the natto angiotensin converting enzyme inhibitor (ACE hibitor) is arranged.The professor of nutrition's of woman university of prophylaxis of hypertension kingdom in 1977 research group just carried out the experiment of natto prophylaxis of hypertension before 20 years, they have made the essential hypertension mouse take in natto every day, with the mouse of taking in the equivalent Semen sojae atricolor in contrast.Consequently, the Mus blood pressure of human consumption soybean raises gradually, and average fluctuation reaches 0.033MPA in 8 months; And the fluctuation peak reaches 0.027MPA in the Mus blood pressure of edible natto 8 months.
Rhizoma Zingiberis Recens extract: modern study finds that Rhizoma Zingiberis Recens is having three effects greatly aspect the anti-angiocardiopathy, the one, and the Rhizoma Zingiberis Recens Wheat Protein, and also all stronger than VC, VE, can prevent the arteriosclerosis that the cholesterol oxidation produces; The 2nd, Rhizoma Zingiberis Recens contains a kind of dilute blood, prevents the material of blood coagulation, blood viscosity lowering; The 3rd, Rhizoma Zingiberis Recens contains a kind of curcumin, and arteriosclerosis plaque and thrombosis are had dissolution.Eat Rhizoma Zingiberis Recens everyday, can prevent and treat coronary heart disease, hyperlipidemia.
U.S. scientist finds that Rhizoma Zingiberis Recens contains a kind of particular matter after deliberation, and similar with salicylic acid, this anticoagulant can not produce any toxic and side effects, and is outstanding to blood fat reducing, blood pressure lowering, preventing thrombosis and anti-myocardial infarction curative effect.Gingerol is one of active skull cap components that is rich in the Rhizoma Zingiberis Recens, pharmacological action: have the anti-gastric-ulcer of being good for the stomach, function of gallbladder promoting, protect the liver, the effect of heart tonifying, anticoagulant, anti-corona, antitumor, maincenter inhibition, enhancing immunity, antibiotic, parasite killing, antiinflammatory, also have very strong oxidation resistance.
" Rhizoma Zingiberis Recens is kept away hundred heresies ".Rhizoma Zingiberis Recens not only can increase delicious food, and, good dietetic therapy drug effect is also arranged, so saying of " winter eats the Radix Raphani summer and eats Rhizoma Zingiberis Recens, writes out a prescription without the doctor ", " winter has Rhizoma Zingiberis Recens not to be afraid of hardships ", " man can not no Rhizoma Zingiberis Recens on the three " arranged from ancient times.
Rhizoma Zingiberis Recens is a kind of potent circulation excitants, vasodilation.
Have above special nutrition and medical treatment, health care just because of Rhizoma Zingiberis Recens, thus Rhizoma Zingiberis Recens be put into that China's Ministry of Public Health determines be food be again the first batch of list of medicine.
Experiment shows Rhizoma Zingiberis Recens extract normal anesthetized rabbit to be had certain effect that brings high blood pressure down and slow down heart rate, and is particularly remarkable to the influence of diastolic pressure and heart rate especially.
Herba Apii graveolentis extract: the important component apigenin is arranged in the Herba Apii graveolentis, can bring high blood pressure down and influence nervus centralis.About blood pressure lowering mechanism, the reflection of tentatively thinking to see through the chemoreceptor of cephalic artery body and aortic arch causes.Blood vessel is inculcated test, proves that apigenin also has the effect of certain expansion peripheral vessel, and this and hypotensive effect also have certain relation.After deliberation, Herba Apii graveolentis have the effect of protection action of the heart and treatment Parkinson's disease.
Radix Rhodiolae extract: main effective ingredient is rhodioloside (Salidroside) and glycoside unit thereof.Mainly contain central inhibitory action, antifatigue effect, cardiotonic, antiinflammatory action, the effect of inhibition blood sugar increasing, anti-peroxidation effect, resisting microwave radiation effect.
Radix Rhodiolae is very long at the applicating history of China, and just on the books in Shennong's Herbal: Herba hylotelephii erythrosticti has the effect of making light of one's life by commiting suicide and making eye bright.Li Shizhen (1518-1593 A.D.) in Compendium of Material Medica grass portion the 20 volume under " Herba hylotelephii erythrosticti " classification dated Radix Rhodiolae be that book on Chinese herbal medicine is top grade, mainly function is " strengthening the body resistance ".
Radix Rhodiolae is because the adjusting benefiting action special to function of human body, and valued highly for imperial family by Ancient Chinese, and in the producing region of Radix Rhodiolae, among the people then with it as tonic and be used for the treatment of disease.In China northeast, Radix Rhodiolae commonly used among the people comes disease preventing and treating as tonic, fries in shallow oil water or steeps in wine and eliminate fatigue that heavy physical labour brings and cold in winter of opposing high and cold mountain area with it.According to record, Emperor Kangxi is in calming down the smooth armed rebellion that splits the motherland of absurd my cloth of plan, the long-distance the Northwest that goes on an expedition in China's arid, because Radix Ginseng is scorching should not be taken, just it is tired out to eliminate army with Radix Rhodiolae, and later successive dynasties emperor once sent special exploring party to remove to seek Radix Rhodiolae, and to ask for Radix Rhodiolae to various places be tribute, qianlong years, Mongolian Shi Er employ special portion to give when basin, Russian Volga is reunited with the motherland the tribute of Emperor Qianlong just Radix Rhodiolae.
In China Tibet, before more than 1,000 year, Tibetan people is just known with Radix Rhodiolae in the years of struggling with rugged environment and is come body-building to strengthen body, opposing and adapt to harsh natural environment, on the Tibetanmedicine document Four-Volume Medical Code, " month king's medicine treasure " and " brilliant pearl book on Chinese herbal medicine " all relevant for the medicinal record of Radix Rhodiolae." brilliant pearl book on Chinese herbal medicine " goes up record: Radix Rhodiolae is cool in nature, puckery, effect be for supporting lung, the heat that disappears, nourish vigour, going halitosis etc.In recent years, the Tibetan people are referred to as " plateau Radix Ginseng ", and prevent and treat multiple disease with it, as treatment high altitude anoxia and high altitude heart disease etc.
The sixties former Soviet Union S .M.Kirov Military medical academy has been found Radix Rhodiolae when seeking analeptic, and it has been carried out deep research, point out that Radix Rhodiolae has the effect of the similar traditional Chinese medical science " strengthening the body resistance ", and its enhance immunity effect can be better than Radix Ginseng.
Professor Sa Lajikefu of former Soviet Union Tomsk medical university thinks: when tired body can not recover naturally, taking Radix Rhodiolae then had remarkable result.The former Soviet Union among the people with Radix Rhodiolae as a kind of analeptic, be applied to patients such as senile heart failure, sexual impotence and diabetes.The seventies Soviet Union has made preparations such as Radix Rhodiolae extractum, is widely used in spaceman, pilot, diver, athlete's etc. daily health caring.
Radix Rhodiolae has dual regulation to human body; its function is the optimal stimulation at human nerve and hormonal system; the potential function of human body is started; produce and keep normal identification, feedback function; and then make decline and hyperfunction human nerve and hormonal system carry out self regulation, reach protection, keep the purpose of health.Without any side effects or the addiction of Radix Rhodiolae, essential reason just are that Radix Rhodiolae and glycoside unit thereof have enlivened in conjunction with phosphorylation with carbohydrate, the lipid oxidizing process as oxidation matrix.Thereby Radix Rhodiolae has the metabolism of the human body energy of promotion, the excitement of exciting nerve, biological effects such as endocrine regulation function and antitoxin detoxifcation.Because Radix Rhodiolae is given birth to volt in high and cold, anoxia, strong ultraviolet radiation, high altitude localities that day and night temperature is big more, the very suitable Radix Rhodiolae growth of Tibet plateau unique natural environment is so Rhodiola tibetica (Hook. f. et Thoms.) S. H. Fu kind number accounts for more than 1/3rd of the world total.
3, introduce somatopsychic medicine, the antidepressant factor of regulating emotion arranged in the present invention's prescription:
Rhizoma et radix valerianae extract: Rhizoma et radix valerianae extract is used for calmness, hypnosis, convulsion clinically.These Rhizoma et radix valerianae chemical compounds may be to come loose smooth muscle cell as a kind of close muscle agent, rather than by interacting with autonomic nervous system.Kessyl alcohol and the 2 kinds of pure and mild acetic acid ring of guainane type sesquiterpene kessane Valeriana Fauriei Briq. alcohol esters thereof all show strong antidepressant effect.Valerianine also has antidepressant effect.The antidepressant effect of Rhizoma et radix valerianae may be relevant with its energy strong inhibition GABA receptor affinity.
Rhizoma et radix valerianae can reduce the incubation period of sleep, obviously improves the sleep quality.
The Rhizoma et radix valerianae ethanol extraction has the effect of tangible expansion coronary vasodilator.In addition, find that also the Rhizoma et radix valerianae ethanol extraction also has tangible dilating effect to isolated rabbit renal blood vessels, skin and striate blood vessel.Valerian preparation also has antioxidation, antifatigue effect.
Rhizoma et radix valerianae has been included in 2000 version " American Pharmacopeia " as the All Pure Nature medicine.
4. raw material sources of the present invention are natural, and human body is not had injury
Raw material of the present invention all is the natural elite of selecting through meticulously:
1), the present invention adopts calcium, magnesium, potassium, the zinc of chelating amino acids to make raw material, this is a kind of high-tech biological product, form by 2 human body essential amino acid molecules and 1 mineral atom chelating, the absorption pattern of this chelate is by the distinctive absorption approach of aminoacid, directly enter cell and absorbed rapidly, therefore high bioavailability is arranged.Amino-acid chelate does not disturb the absorption of other elements and other mineral element not to have antagonism.
2), to adopt nutritious unartificial yeast be raw material in the present invention, Selenium Supplement.Yeast is the widest microorganism of human use.Yeast rich in selenium combines selenium and yeast interior protein, polysaccharide with natural nutrition yeast assimilation inorganic selenium, the easier utilization that is absorbed by the body, and do not have toxic and side effects, be good organic selenium source.
Yeast has the selenium rich ability of height, reach the ability that chemical selenium is converted into biological selenium, yeast rich in selenium is exactly to add the selenium element in the process of culture yeasts, by yeast in growth course to selenic autonomous absorption and conversion, make the selenium utilization that can more efficient, more safely be absorbed by the body.Yeast rich in selenium also is the most efficient, the safest domestic up to now, the most isostatic selenium-replenishing preparation of nutrition.Characteristics are:
A. content height;
B. selenium in the selenium-enriched yeast of bioavailability and the albumen in the yeast organically combine, and its human absorptivity is higher than inorganic selenium far away.
C. the advanced technology Development of Yeast Containing Abundant Se is produced and is related to high-tech biotechnology such as bio-genetics technology, microbial fermentation technology, biological enzymolysis technology, microcapsule technology, emulsifying technology, ultramicrotechnique.
3), linolenic acid dry powder, be raw material with the rare wild plant Cortex Eucommiae in the Yunnan-Guizhou Plateau, Folium Perillae, adopt advanced CO
2Supercritical extraction, and special leaching process is refining forms pure 100% natural components.Linolenic acid content reaches more than 80%.
4), other raw materials all are the plants of adopting integration of edible and medicinal herbs, as Semen Ginkgo, natto, Rhizoma Zingiberis Recens, Herba Apii graveolentis, Radix Rhodiolae etc., by modern biotechnology, the concentration extraction effective ingredient.Raw material is natural to have no side effect, and has demonstrated fully the aim of natural dietetic therapy.Simultaneously because the active constituent content height has been strengthened effect again.
5. various nutrient substance and the active component work compound in the present invention's prescription is indispensable, plays the effect of prevention cardiovascular and cerebrovascular disease and auxiliary treatment cardiovascular and cerebrovascular disease when supplementing the nutrients.
As a kind of comprehensive nutrient compensation process at the cardiovascular and cerebrovascular vessel patient, pass through many-sided check in practice, effect is very remarkable, and natural having no side effect is a kind of ideal natural dietetic therapy articles for use.
Through overtesting, following statistical data can illustrate the result of use of taking a product of the present invention course of treatment (3 months):
| Group | Number | Effective number | Effective ratio | Remarkable result | The produce effects ratio |
| The Wuhan group | 230 people | 203 people | 88.3％ | 165 people | 71.7％ |
| The Xiamen group | 150 people | 135 people | 90％ | 98 people | 65.3％ |
| Beijing group | 320 people | 295 people | 92.2％ | 220 people | 68.8％ |
| Add up to | 700 people | 504 people | 90.4％ | 483 people | 69％ |
The specific embodiment
Enumerate embodiment below, the present invention is further specified, but the present invention is not only limited to these embodiment.
Embodiment 1
25 tons of yeast rich in seleniums; 150 tons of chelating type calcium aminosuccinic acids; 150 tons of chelating type Aspartic acid magnesiums; 20 tons of chelating type zinc glycinate; 300 tons of L-Aspartic acid potassiums; 0.15 ton in folic acid; 25 tons in linolenic acid dry powder; 90 tons of natto lyophilized powder; 50 tons of Folium Ginkgo extract; 50 tons of Rhizoma Zingiberis Recens extracts; 100 tons of Herba Apii graveolentis extract; 50 tons of Radix Rhodiolae extracts; 50 tons of Rhizoma et radix valerianae extracts;
Can also add adjuvant in the above-mentioned raw materials, be beneficial to making of tablet.Adjuvant: microcrystalline Cellulose, magnesium stearate, dextrin amount to 130 tons.
1, above-mentioned raw materials and ingredient powder are broken to 80～200 orders;
2, above-mentioned raw materials and adjuvant are placed mixing tank jointly, fully mixing;
3, in tablet machine, feed intake, tabletting;
Embodiment 2
Yeast rich in selenium 25mg (containing selenium 50 micrograms); Chelating type calcium aminosuccinic acid (calcium content 10%) 150mg (containing Ca:15mg); Chelating type Aspartic acid magnesium (magnesium content 10%) 150mg (containing Mg:15mg); Chelating type zinc glycinate (zinc content 20%) 20mg (containing Zn:4mg); L-Aspartic acid potassium (potassium content about 16%) 300mg (containing K:50mg); Folic acid 0.1mg (100 μ g); The numb sour dry powder 25mg of industry (contains linolenic acid: 20mg); Natto lyophilized powder 100mg; Folium Ginkgo extract 50mg; Rhizoma Zingiberis Recens extract 50mg; Herba Apii graveolentis extract 100mg; Radix Rhodiolae extract 50mg; Rhizoma et radix valerianae extract 50mg; Adjuvant: microcrystalline Cellulose, magnesium stearate, dextrin are that 70: 10: 20 ratio is formulated with weight ratio, amount to 130mg.
Be prepared from according to embodiment 1 described method.
Embodiment 3-9
Embodiment 3-9 is prepared from according to embodiment 1 described method, and proportioning sees Table 1.
Table 1
| Raw material (kg) | Embodiment 3 | Embodiment 4 | Embodiment 5 | Embodiment 6 | Embodiment 7 | Embodiment 8 | Embodiment 9 |
| Yeast rich in selenium | 15 | 35 | 20 | 25 | 30 | 28 | 22 |
| The chelating type calcium aminosuccinic acid | 100 | 200 | 150 | 120 | 180 | 140 | 160 |
| The chelating type Aspartic acid magnesium | 100 | 200 | 180 | 140 | 160 | 150 | 120 |
| The chelating type zinc glycinate | 10 | 30 | 15 | 20 | 25 | 22 | 18 |
| The L-Aspartic acid potassium | 200 | 400 | 250 | 350 | 300 | 280 | 330 |
| Folic acid | 0.01 | 1 | 0.02 | 0.05 | 0.1 | 0.2 | 0.5 |
| Linolenic acid dry powder | 28 | 22 | 15 | 35 | 20 | 25 | 30 |
| Natto lyophilized powder | 50 | 150 | 80 | 100 | 120 | 90 | 110 |
| Folium Ginkgo extract | 40 | 60 | 50 | 45 | 55 | 48 | 53 |
| Rhizoma Zingiberis Recens extract | 20 | 80 | 45 | 40 | 50 | 60 | 55 |
| Herba Apii graveolentis extract | 80 | 100 | 120 | 50 | 150 | 90 | 110 |
| Radix Rhodiolae extract | 50 | 45 | 53 | 55 | 48 | 40 | 60 |
| Rhizoma et radix valerianae extract | 50 | 45 | 55 | 48 | 40 | 60 | 53 |
| Adjuvant | 100 | 150 | 125 | 120 | 130 | 140 | 135 |
Adjuvant: microcrystalline Cellulose, magnesium stearate, dextrin are that 70: 10: 20 part by weight is formulated with weight ratio
Raw materials used manufacturer in the foregoing description:
Table 2
| Raw material | Raw material supply unit |
| Yeast rich in selenium | Angel Yeast company |
| The chelating calcium aminosuccinic acid | The grand new medicine in Shanghai |
| The chelating Aspartic acid magnesium | |
| The chelating zinc glycinate | |
| The L-Aspartic acid potassium | The emerging industry in the Huaibei, Anhui |
| Folic acid | Food is encouraged in Shanghai |
| Linolenic acid dry powder | Xuchang unitization company |
| Natto lyophilized powder | Wuhan son of the east biotech firm |
| Folium Ginkgo extract | Tianjin spike biotech firm |
| Rhizoma Zingiberis Recens extract | |
| Herba Apii graveolentis extract | |
| Radix Rhodiolae extract | |
| Rhizoma et radix valerianae extract | |
| Other adjuvants: microcrystalline Cellulose, magnesium stearate, dextrin |
Claims (5)
1. health product that are used for cardiovascular and cerebrovascular disease are formulated according to parts by weight by following raw material: yeast rich in selenium 15-35 part; Chelating type calcium aminosuccinic acid 100-200 part; Chelating type Aspartic acid magnesium 100-200 part; Chelating type zinc glycinate 10-30 part; L-Aspartic acid potassium 200-400 part; Folic acid 0.01-1 part; Linolenic acid dry powder 15-35 part; Natto lyophilized powder 50-150 part; Folium Ginkgo extract 40-60 part; Rhizoma Zingiberis Recens extract 20-80 part; Herba Apii graveolentis extract 50-150 part; Radix Rhodiolae extract 40-60 part; Rhizoma et radix valerianae extract 40-60 part.
2. according to the described health product that are used for cardiovascular and cerebrovascular disease of claim 1, it is characterized in that these health product that are used for cardiovascular and cerebrovascular disease are formulated according to parts by weight by following raw material: yeast rich in selenium 20-30 part; Chelating type calcium aminosuccinic acid 120-180 part; Chelating type Aspartic acid magnesium 120-180 part; Chelating type zinc glycinate 15-25 part; L-Aspartic acid potassium 250-350 part; Folic acid 0.05-0.2 part; Linolenic acid dry powder 20-30 part; Natto lyophilized powder 80-120 part; Folium Ginkgo extract 45-55 part; Rhizoma Zingiberis Recens extract 40-60 part; Herba Apii graveolentis extract 80-120 part; Radix Rhodiolae extract 45-55 part; Rhizoma et radix valerianae extract 45-55 part.
3. according to the described health product that are used for cardiovascular and cerebrovascular disease of claim 1, it is characterized in that these health product that are used for cardiovascular and cerebrovascular disease are formulated according to parts by weight by following raw material: 25 parts of yeast rich in seleniums; 150 parts of chelating type calcium aminosuccinic acids; 150 parts of chelating type Aspartic acid magnesiums; 20 parts of chelating type zinc glycinate; 300 parts of L-Aspartic acid potassiums; 0.15 part in folic acid; 25 parts in linolenic acid dry powder; 90 parts of natto lyophilized powder; 50 parts of Folium Ginkgo extract; 50 parts of Rhizoma Zingiberis Recens extracts; 100 parts of Herba Apii graveolentis extract; 50 parts of Radix Rhodiolae extracts; 50 parts of Rhizoma et radix valerianae extracts.
4. according to the described health product that are used for cardiovascular and cerebrovascular disease of claim 1, it is characterized in that, also comprise adjuvant 100-150 part in the raw material, described adjuvant comprises microcrystalline Cellulose, magnesium stearate, dextrin, and be 70 parts with ratio of weight and number: 10 parts: 20 parts ratio is formulated.
5. according to the described health product that are used for cardiovascular and cerebrovascular disease of claim 4, it is characterized in that, also comprise 130 parts of adjuvants in the raw material.
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| CNB2005101347443A CN100473415C (en) | 2005-12-21 | 2005-12-21 | Health-care product for treating cardiovascular and cerebralvascular disease |
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| CNB2005101347443A CN100473415C (en) | 2005-12-21 | 2005-12-21 | Health-care product for treating cardiovascular and cerebralvascular disease |
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| CN100473415C CN100473415C (en) | 2009-04-01 |
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| CN103766904A (en) * | 2014-01-22 | 2014-05-07 | 重庆师范大学 | Preparation of capsule with function of lowering lipid and facilitating feces excretion and application of capsule |
| CN103800396A (en) * | 2014-02-19 | 2014-05-21 | 北京高平技术开发有限公司 | Composite healthcare product for promoting coronary circulation and preparation method thereof |
| CN104431063A (en) * | 2014-11-13 | 2015-03-25 | 董珉 | Leaf of strigose hydrangea functional beverage for preventing and treating cardiovascular and cerebrovascular diseases and preparation method thereof |
| CN107998227A (en) * | 2016-10-28 | 2018-05-08 | 新时代健康产业（集团）有限公司 | A kind of health products of cardioprotection and preparation method thereof |
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| CN102218054A (en) * | 2011-04-19 | 2011-10-19 | 首都医科大学 | Use of apigenin in preparing drugs for preventing and/or treating cardiovascular and cerebrovascular diseases |
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- 2005-12-21 CN CNB2005101347443A patent/CN100473415C/en not_active Expired - Fee Related
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| CN103766904A (en) * | 2014-01-22 | 2014-05-07 | 重庆师范大学 | Preparation of capsule with function of lowering lipid and facilitating feces excretion and application of capsule |
| CN103800396A (en) * | 2014-02-19 | 2014-05-21 | 北京高平技术开发有限公司 | Composite healthcare product for promoting coronary circulation and preparation method thereof |
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| CN104431063A (en) * | 2014-11-13 | 2015-03-25 | 董珉 | Leaf of strigose hydrangea functional beverage for preventing and treating cardiovascular and cerebrovascular diseases and preparation method thereof |
| CN107998227A (en) * | 2016-10-28 | 2018-05-08 | 新时代健康产业（集团）有限公司 | A kind of health products of cardioprotection and preparation method thereof |
| CN111671078A (en) * | 2020-04-17 | 2020-09-18 | 山东哈维药业有限公司 | Blood vessel maintenance composition containing kefir fermented milk powder and preparation method thereof |
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| Publication number | Publication date |
|---|---|
| CN100473415C (en) | 2009-04-01 |
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