CN1806812A - Preparation method of gingko leaf soft capsule - Google Patents
Preparation method of gingko leaf soft capsule Download PDFInfo
- Publication number
- CN1806812A CN1806812A CN 200510002416 CN200510002416A CN1806812A CN 1806812 A CN1806812 A CN 1806812A CN 200510002416 CN200510002416 CN 200510002416 CN 200510002416 A CN200510002416 A CN 200510002416A CN 1806812 A CN1806812 A CN 1806812A
- Authority
- CN
- China
- Prior art keywords
- soft capsule
- folium ginkgo
- peg
- ginkgo extract
- antiseptic
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
Landscapes
- Medicines Containing Plant Substances (AREA)
- Medicinal Preparation (AREA)
Abstract
The invention provides a gingko leaf soft capsule formulation and its preparation process, wherein each unit comprises total flavonoids 19.2mg, ginkgo terpene lactones 4.8mg, or total flavonoids 40mg, and ginkgo terpene lactones 10mg.
Description
The present invention relates to a kind of treatment blood circulation promoting and blood stasis dispelling, the ginkgo leaf soft capsule preparation and the production method thereof of TONGMAI SHULUO.
The ginkgo leaf soft capsule Chinese patent medicine that to be a kind of single medicinal material make through modern extraction process: mainly contain blood circulation promoting and blood stasis dispelling, effects such as TONGMAI SHULUO are used for the thoracic obstruction, apoplexy that syndrome of blood stasis causes, and that disease is seen is uncomfortable in chest, cardiopalmus, stiff tongue and retardation in speech, hemiplegia etc.The inventor is through studying and test the pharmacology and the pharmacodynamics of Folium Ginkgo extract, and analyzed the physicochemical characteristics of Folium Ginkgo extract, think and to accelerate disintegrate in vivo, improve bioavailability if Folium Ginkgo extract is made soft capsule.Now on the market soft capsule content have only every contain total flavonoids 9.6mg, terpene lactone 2.4mg relative amount is lower, the present invention refers to contain total flavonoids 19.2mg, terpene lactone 4.8mg and every soft capsule product that contains total flavonoids 40mg, terpene lactone 10mg providing a kind of effective component content to reach every.Technical solution of the present invention is as follows:
1, a kind of ginkgo leaf soft capsule is characterized in that this soft capsule contains and is equivalent to Folium Ginkgo extract 75～200mg.
2, ginkgo leaf soft capsule is characterized in that this soft capsule contains total flavonoids 18～48mg, terpene lactone 4.5～12mg.
3, a kind of ginkgo leaf soft capsule is characterized in that this soft capsule prepares with following method:
Embodiment one:
Folium Ginkgo extract 75～200g
Glycerol is an amount of
PEG
6000In right amount
PEG
400In right amount
Get PEG
400In an amount of appropriate vessel, add PEG
6000In right amount, heating in water bath is to PEG
6000Dissolve, stir evenly, adding glycerol is an amount of, adds Folium Ginkgo extract and grinds to form even mastic with colloid mill, is transferred to the buffer storge vat of encapsulating machine, is pressed into 1000 of soft capsules with mould, typing, flush away surface lubricant.In 20～30% relative humiditys, dry under 28～30 ℃ of conditions, promptly.
Embodiment two:
The soft capsule of this method preparation partly is made of medicinal liquid and softgel shell two, and it is characterized in that: the composition of described liquid medicine material and part by weight thereof are: Folium Ginkgo extract: vegetable oil: Cera Flava=0.5～1.5: 2.0～6.0: 0.08～0.2; The composition of capsule casing material and part by weight thereof are: gelatin: glycerol: water: antiseptic=0.9～1.1: 0.3～0.5: 0.9～1.1: 0.001～0.003.Wherein vegetable oil is one or more in the edible oils such as soybean oil, Oleum Arachidis hypogaeae semen, Oleum Camelliae.Antiseptic is that mud pool tortoise beetle ester, mud moor gold ethyl ester, mud are moored golden propyl ester etc. and can be added on one or more in the antiseptic in the food.
Get Cera Flava and put in the vegetable oil, be heated to fusion, put be chilled to room temperature after, add Folium Ginkgo extract, stir evenly with the colloid barreling, must medicinal liquid.
Get gelatin, glycerol, water, put the vessel in heating dissolving, filter, filtrate adds antiseptic, and mixing gets rubber solution.
Get above-mentioned medicinal liquid and rubber solution, with the compression moulding of soft capsule production equipment, after the drying promptly.
4, ginkgo leaf soft capsule is characterized in that the used Folium Ginkgo extract of this soft capsule contains total flavonoids more than 24%, and terpene lactone is more than 6%.
Claims (3)
1, a kind of ginkgo leaf soft capsule is characterized in that this soft capsule contains and is equivalent to Folium Ginkgo extract 75～200mg.
2, soft capsule according to claim 1 is characterized in that this soft capsule contains total flavonoids 18～48mg, terpene lactone 4.5～12mg.
3, a kind of ginkgo leaf soft capsule is characterized in that this soft capsule prepares with following method:
Embodiment one:
Folium Ginkgo extract 75～200g
Glycerol is an amount of
PEG
6000In right amount
PEG
400In right amount
Get PEG
400In an amount of appropriate vessel, add PEG
6000In right amount, heating in water bath is to PEG
6000Dissolve, stir evenly, adding glycerol is an amount of, adds Folium Ginkgo extract and grinds to form even mastic with colloid mill, is transferred to the buffer storge vat of encapsulating machine, is pressed into 1000 of soft capsules with mould, typing, flush away surface lubricant.In 20～30% relative humiditys, dry under 28～30 ℃ of conditions, promptly.
Embodiment two:
The soft capsule of this method preparation partly is made of medicinal liquid and softgel shell two, and it is characterized in that: the composition of described liquid medicine material and part by weight thereof are: Folium Ginkgo extract: vegetable oil: Cera Flava=0.5～1.5: 2.0～6.0: 0.08～0.2; The composition of capsule casing material and part by weight thereof are: gelatin: glycerol: water: antiseptic=0.9～1.1: 0.3～0.5: 0.9～1.1: 0.001～0.003.Wherein vegetable oil is one or more in the edible oils such as soybean oil, Oleum Arachidis hypogaeae semen, Oleum Camelliae.Antiseptic is that mud pool tortoise beetle ester, mud moor gold ethyl ester, mud are moored golden propyl ester etc. and can be added on one or more in the antiseptic in the food.
Get Cera Flava and put in the vegetable oil, be heated to fusion, put be chilled to room temperature after, add Folium Ginkgo extract, stir evenly with the colloid barreling, must medicinal liquid.
Get gelatin, glycerol, water, put the vessel in heating dissolving, filter, filtrate adds antiseptic, and mixing gets rubber solution.
Get above-mentioned medicinal liquid and rubber solution, with the compression moulding of soft capsule production equipment, after the drying promptly.4, soft capsule according to claim 1 is characterized in that the used Folium Ginkgo extract of this soft capsule contains total flavonoids more than 24%, and terpene lactone is more than 6%.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN 200510002416 CN1806812A (en) | 2005-01-21 | 2005-01-21 | Preparation method of gingko leaf soft capsule |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN 200510002416 CN1806812A (en) | 2005-01-21 | 2005-01-21 | Preparation method of gingko leaf soft capsule |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CN1806812A true CN1806812A (en) | 2006-07-26 |
Family
ID=36839022
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN 200510002416 Pending CN1806812A (en) | 2005-01-21 | 2005-01-21 | Preparation method of gingko leaf soft capsule |
Country Status (1)
| Country | Link |
|---|---|
| CN (1) | CN1806812A (en) |
Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN103550267A (en) * | 2013-11-15 | 2014-02-05 | 石家庄市华新药业有限责任公司 | Folium ginkgo soft capsule and preparation method thereof |
| CN108272832A (en) * | 2018-04-10 | 2018-07-13 | 辽宁仙草堂药业有限公司 | A kind of ginkgo leaf soft capsule and preparation method thereof |
-
2005
- 2005-01-21 CN CN 200510002416 patent/CN1806812A/en active Pending
Cited By (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN103550267A (en) * | 2013-11-15 | 2014-02-05 | 石家庄市华新药业有限责任公司 | Folium ginkgo soft capsule and preparation method thereof |
| CN103550267B (en) * | 2013-11-15 | 2016-01-20 | 石家庄市华新药业有限责任公司 | A kind of ginkgo leaf soft capsule and preparation method thereof |
| CN108272832A (en) * | 2018-04-10 | 2018-07-13 | 辽宁仙草堂药业有限公司 | A kind of ginkgo leaf soft capsule and preparation method thereof |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| Shishikura et al. | Effects of tea polyphenols on emulsification of olive oil in a small intestine model system | |
| CN104957602B (en) | Sugarcane active component composition and functional health-care food and preparation method thereof | |
| JP5851240B2 (en) | Method for preparing muscadine pomace extract | |
| JP5608646B2 (en) | Muscadine composition having improved antioxidant activity | |
| JP2019505163A (en) | Method for formulating an orally ingestible composition comprising a fat-soluble active substance | |
| JP2019501626A (en) | Stable ready-to-drink beverage composition comprising a fat-soluble active substance | |
| CN101810550A (en) | Cosmetics or cosmeceutical mixture containing bilberry extract | |
| Oliveira et al. | Food-derived polyphenol compounds and cardiovascular health: A nano-technological perspective | |
| JP6010665B2 (en) | Muscle bulking agent | |
| CN1806812A (en) | Preparation method of gingko leaf soft capsule | |
| CN105997680A (en) | Method for preparing beautifying healthcare mask with banana skin | |
| EP2377875B1 (en) | Antioxidant | |
| KR20110105627A (en) | Anti-obesity composition containing silkworm hemolymph | |
| FR2882933A1 (en) | USE OF ONION EXTRACT FOR THE MANUFACTURE OF A COMPOSITION FOR CONTROLLING WEIGHT TAKING | |
| KR100884059B1 (en) | Composition comprising powder of a seatangle or the removed alginate extract therefrom having antioxidant and anti-arteriosclerosis activity | |
| JP5661309B2 (en) | Anti-obesity agent | |
| CN107006622A (en) | A kind of healthy edible oil and preparation method thereof | |
| CN109022139A (en) | A method of quickly preparing prinsepia utilis royle oil | |
| CN105995800A (en) | Lotus fragrance beauty qi-tonifying jam and preparation method thereof | |
| CN105995804A (en) | Strawberry jam with asiatic bilberry leaves and effects of improving eyesight and calming nerves and method for preparing strawberry jam | |
| CN105942385A (en) | Lipid lowering and beautifying jam with lotus root fragrance and flos rosae rugosae and method for preparing lipid lowering and beautifying jam | |
| JP7412743B2 (en) | A composition for improving tear volume, a composition for improving constipation, and a composition for improving skin quality. | |
| KR101138565B1 (en) | Composition for the prevention or treatment of obesity or lipid related metabolic deseases | |
| CN101637481A (en) | Prescription of gingkgo leaf soft capsule and preparation method thereof | |
| ES2577889B1 (en) | USE OF COFFEE HAND PRODUCTS FOR THE PREVENTION AND TREATMENT OF PATHOLOGIES THAT CONFORM THE METABOLIC SYNDROME AND ITS RISK FACTORS |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| C06 | Publication | ||
| PB01 | Publication | ||
| C57 | Notification of unclear or unknown address | ||
| DD01 | Delivery of document by public notice |
Addressee: Chen Yihuai Document name: Notification before expiration of term |
|
| C57 | Notification of unclear or unknown address | ||
| DD01 | Delivery of document by public notice |
Addressee: Chen Yihuai Document name: Notification that Application Deemed to be Withdrawn |
|
| C02 | Deemed withdrawal of patent application after publication (patent law 2001) | ||
| WD01 | Invention patent application deemed withdrawn after publication |