CN1786134A - Multifunction antiseptic sterilizing cleaning agent composition and its preparation method - Google Patents
Multifunction antiseptic sterilizing cleaning agent composition and its preparation method Download PDFInfo
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Abstract
The invention relates to a multifunction disinfection sterilization detergent combination and the making method. It adopts quaternary ammonium salt, biguanide species, chelating agent, chlorine-hydroxyl diphenyl ether, fatty alcohol compound, organic acid compound, and nonionic reaction compound to make disinfection sterilization detergent. It is non-toxic and without side effect. So it can be widely used in various industries.
Description
Technical field
The present invention relates to washing composition class chemical and make the field, particularly relate to a kind of multifunction antiseptic sterilizing cleaning agent composition and preparation method thereof.
Background technology
Sterilization and sterilization that glutaraldehyde is used for accurate diagnostic equipment have had the history of more than 40 year degree, it has high-caliber sterilization and sterilization ability, in medical treatment and other industry, be widely used, for global hygiene and health cause has been made huge contribution, yet secular use makes people also find its toxic side effect, as its easy volatile bring to the human body respiration organ, the pungency of eyes, directly contact causes the skin surface sex change, the generation of dermatitis fash, in addition, the unstable of glutaraldehyde has also influenced further promoting the use of of it to a certain extent, in recent years, release o-phthalaldehyde(OPA) both at home and abroad as new high level disinfection agent, this sterilizing agent volatility is relatively low, pungency to people's respiratory organs is also relatively low, but, it is but very serious to the stimulation of skin and mucous membrane, and make the protein variable color easily and can not be in the skin contact of animal, thereby the large-scale popularization that has influenced it is used, in addition, the biological degradability of o-phthalaldehyde(OPA) is difficult, is emitted on the pollution that easily causes environment in the environment.
All kinds of endoscopes of hospital use increasingly extensive at present, frequency of usage is more and more higher, itself is a kind of precision instrument that has miniature video camera, illumination and small instruments system, have the longer pipe chamber, it is mainly worked in the chamber of human body, directly contacts people's mucous membrane, blood and organ, very easily be infected with all kinds of germs and virus, if sterilization is not thorough, can cause the cross infection accident, bring infringement to people health.Because the singularity of the material of endoscope, it is to oxidisability, corrosive chemical and high-temperature operation have hypersensitivity, and long luminal structure makes its cleaning and sterilizing comparatively difficult, United States Patent (USP) " Process and composition for cleaning medical instrumentscomprising protease and quaternary ammonium disinfectant " (application number: 6762161 applying date july13 for this reason, 2004) many trials have been done in these areas, obtained certain progress, this technology mainly adopts benzethonium chloride, benzene rope bromine ammonium or other alkyl class quaternary ammonium salt, by with other tensio-active agent allotment made high level disinfection agent and high-grade hospital disinfectant more, but there are many problems in it, relatively poor as the organic influence of 1. antagonism, just can put into sterilized container after must soaking earlier and wash before sterilization of instruments or the sterilization and soak through special enzyme lotion; 2. schedule of operation is many, the use cost costliness; 3. the design of this system does not comprise the sterilizing function of human body skin, hand and others, does not have real long bacteriostasis efficacy yet, therefore is restricted in application facet.United States Patent (USP) " Receiving circuit, mobile terminal with receiving circuit, and method ofreceiving data " (application number: US768769, applying date july27,2004) then take benzethonium chloride, benzene rope bromine ammonium or other alkyl lamp quaternary ammonium salt, made the high level disinfection agent by allocating with Fatty Alcohol(C12-C14 and C12-C18), it can use the sterilization with people's skin and body surface, owing to must use relatively large Fatty Alcohol(C12-C14 and C12-C18) to play synergism, but this use also brings strong impulse simultaneously, and because the easy volatile of alcohol makes the fungicidal activity of composition and stability be subjected to very big influence; The design of this combination has only single benzethonium chloride or benzene rope bromine ammonium sterilization main component in addition, causes product activity and additional function relatively poor.United States Patent (USP) " Disinfectant composition " (application number: US6441045, applying date August27,2002), adopt the formula system of benzethonium chloride, accomplished the ability (logarithmic value reduces 〉=3) of high level disinfection, nontoxic, tasteless, do not have characteristics such as corrosion, can application and the sterilization of foodstuffs industry, human body and animal body, body surface, hospital equipment etc., but do not accomplish sterilization level (gemma logarithmic value reduction 〉=5); Again because the sterilization main component benzethonium chloride of this individual system,, actually the speed of fungi and gemma is killed effect and the long term inhibition effect is not accomplished if there is not the synergy of other medicines; This is compound fat-soluble stronger of benzethonium chloride, the benzene rope bromine ammonium of phenyl ring in addition, and the skin of human body is easily caused degreasing, and especially life-time service easily causes pachylosis, chaps and fash etc.; The compound of benzethonium chloride, benzene rope bromine ammonium than difficult degradation, can run into many puzzlements and problem when reality is used in the environment of nature in addition.
Summary of the invention
The objective of the invention is to overcome the defective of above-mentioned prior art, provide a kind of to person poultry safety, nontoxic, rapidly and efficiently, and broad-spectrum disinfection-sterilization washing composition with good cleaning-sterilizing function, this antiseptic sterilizing cleaning agent not only can be applied to human body skin and hand, animal, livestock and poultry, culture fishery, food industry machine, body surface, gourd, fruit and vegetable, tableware, and can be used as sterilization and sterilization that high level disinfection and disinfectant are applied to accurate medical facilities.
Technical scheme of the present invention is:
A kind of multifunction antiseptic sterilizing cleaning agent composition is characterized in that said composition is to be formed by the following substances proportioning:
Chlorine-dihydroxy diphenyl ether 0.01%-1%;
Quarternary ammonium salt compound 0.01%-12%;
Biguanide compound 0.02%-5%;
Chelant compounds 0.1%-5%;
Fat alcohol compound 1%-30%;
Organic acid compound 0.01%-3%;
Non-ionic surface compound 0.01%-20%;
Spices 0.01%-1%;
Pigment 0.001%-0.5%;
Deionized water 30%-70%;
Said ratio by weight percentage;
Described chlorine-dihydroxy diphenyl ether is one chlorine-dihydroxy diphenyl ether, dichloro-dihydroxy diphenyl ether or trichlorine-dihydroxy diphenyl ether;
Described quarternary ammonium salt compound is a C6-C18 alkyl quaternary ammonium salt, is preferably C8-C12 alkyl quaternary ammonium salt;
Described biguanide compound is chlorohaxanpyridine acetate, gluconic acid chlorhexidine or poly-methyl biguanide hydrochloride;
Described chelant compounds is polyphosphoric acid salt, alkyl diamine tetraacethyl or alkyl diamine tetraacetate;
Described fat alcohol compound is ethanol, Virahol, butanols, ethylene glycol, propylene glycol or glycerol;
Described organic acid compound is oxysuccinic acid, tartrate, citric acid, lactic acid or amido sulphur;
Described nonionogenic tenside is fatty alcohol-polyoxyethylene ether, coconut oleoyl amine or poly-alkyl-glucoside.
The preparation method of above-mentioned multifunction antiseptic sterilizing cleaning agent composition, its technological process is:
A. according to formula ratio chelant compounds, doped quaternary ammonium salt compound, biguanide compound, fat alcohol compound and nonionogenic tenside are put into reactor successively, the deionized water that adds formula ratio 1/3rd after stirring, start heating unit simultaneously, under 20 ℃ of-90 ℃ of conditions, continue to stir 30-60 minute;
B. subsequently chlorine-dihydroxy diphenyl ether is joined in the above-mentioned reaction solution, continued heated and stirred 40-50 minute, stop to stir and heating;
C. add the residue deionized water and stirring then after 20-30 minute, add organic acid compound;
D. add spices and pigment at last, stop after restir 30-40 minute;
E. left standstill 60-120 minute, filtration gets final product.
Above-mentioned used spices is the muskmelon odor type of food grade;
Used pigment is the sapphirine of food grade.
Technical characterstic of the present invention is embodied in:
1. the present invention selects for use the compounds such as quaternary ammonium salt, biguanides of no benzene ring structure to form antiseptic sterilizing cleaning agent, make it have broad-spectrum antibacterial activity and high-caliber biocidal efficacies, no side effects again, not only human body skin and hand, animal, livestock and poultry, culture fishery, food industry machine, body surface, gourd, fruit and vegetable, tableware be can be applied to, and sterilization and sterilization that high level disinfection and disinfectant are applied to accurate medical facilities can be used as.
The present invention in design at Gram-negative bacteria, gram-positive microorganism, fungi, the different structure of withered grass tooth born of the same parents and virus and the structure and the active characteristics of active characteristics and germ killing drugs have been carried out the design of scientific system, at first adopted the germ-resistant long-acting bacteriostatic composition of chloro-dihydroxy diphenyl ether to combine with biguanide compound is organic, in composition, produced more excellent under the synergy of other media, peculiar sterilization and long lasting bacteriostatic activity, increased Fatty Alcohol(C12-C14 and C12-C18) simultaneously, nonionogenic tenside, make composition possess good solvent system, make it have excellent dispersion and emulsifying effectiveness and good penetration effect, thereby strengthened the sterilization and the bacteriostatic activity of composition, reached the effect of global function sterilization.
3. sterilization composition all safe and quick, efficient in order to obtain, wide spectrum to people and animals, the present invention adopts the sterilization combination of security, pungency minimum, at first no matter chloro-dihydroxy diphenyl ether sterilant is at long-acting bacteriostatic or is all reaching international level aspect the security of material, next selects the poly double-guanidine compounds for use, this compounds is safe, can directly apply to the processing etc. of foodstuff production, food and people's disposable sanitary articles aspect; Further select the long chain quaternary compounds at last for use, match with above-mentioned two kinds of Fungicidal compounds, thereby founded, pathogenic microorganism is had the extremely strong inhibition and the antiseptic sterilizing cleaning agent composition of killing action healthy skin close friend.
4. in order to obtain body surface and to equip composition with good cleaning action, the present invention has taked special mode on preparation technology, be about to complexing agent, Fatty Alcohol(C12-C14 and C12-C18) and nonionogenic tenside, cats product according to a certain percentage with the modulation of step, this mode can make composition produce excellent washing and cleaning function, and these main components can be degraded into carbonic acid gas and water easily at occurring in nature, can not pollute environment.
In order to verify technique effect of the present invention, the spy has made some relevant sterile test and toxicological tests at the present invention, is specially:
1. present composition stoste is to the determination test of the antibacterial coefficient of fungi
With phenol is coefficient, and antibacterial index calculates with cm, and fungi is selected Candida albicans ATCC10231 for use, and measurement result is as shown in table 1:
Table 1: to the bacteriostatic action test-results of candida albicans ATCC10231
By above table as can be seen: washing composition of the present invention has excellent restraining effect to candida albicans, illustrates that combination solution of the present invention can be applied to the treatment aspect of human body skin tinea disease.
2. present composition stoste is killed the determination test of coefficient to fungi
Positive controls: average colony number 3.42*10
7Cfu/ml;
Negative control group: diluent, nutrient agar medium, sterilized water are cultivated all positive.
Table 2; The test-results of killing to candida albicans ATCC10231
| Decontaminant concentration | The effect different time on average kill logarithmic value (KL) | ||
| 1min | 3min | 5min | |
| Stoste 1/3 diluent | 3.82 | 4.20 | 4.30 |
| Stoste 2/3 diluent | 4.12 | 4.55 | 5.00 |
| Stoste | ≥5 | ≥5 | ≥5 |
As can be seen from the above table: under test conditions, present composition stoste in 1min to the killing rate logarithmic value of candida albicans ATCC10231 greater than 5, therefore can kill candida albicans effectively.
3. present composition stoste is to the test of killing of bacillus subtilis black variety gemma ATCC9372
Table 3: to the test-results of killing of bacillus subtilis black variety gemma ATCC9372
| Effective content (mg/l) | The effect different time on average kill logarithmic value (KL) | ||
| 20min | 30min | 40min | |
| Stoste 1/3 diluent | 2.89 | 2.97 | 3.06 |
| Stoste 2/3 diluent | 3.91 | 4.95 | ≥5 |
| Stoste | ≥5 | ≥5 | ≥5 |
As can be seen from the above table: in the composition stoste 30min of the present invention to the killing rate logarithmic value of bacillus subtilis black variety gemma ATCC9372 greater than 5, illustrate that the present composition can effectively be killed bacillus subtilis black variety gemma.
4. present composition toxicology test
Table 4: toxicology test data
| Test subject | Index |
| Chmice acute per os toxicity test | Female male mouse LD50＞5000MG/kg.BW |
| Cumulative toxicity test | K＞5; Belong to cumulative toxicity test |
| The mouse polychromatic erythrocytes micronucleus test | Negative |
| A skin irritation test of rabbit | Nonirritant |
According to the standard of Ministry of Health's " disinfection technology standard " in April, 2002 version, the present composition belongs to actual nontoxicity product, can directly apply to the washing and the sterilization of human body and foodstuffs industry, medical industry etc.
5. according to the standard of Ministry of Health's " disinfection technology standard " in April, 2002 version, the present invention has been done the metal protection test simultaneously, the result is as follows: soaked stainless steel, carbon steel, copper, aluminium flake 72 hours with present composition stoste, discovery has mild corrosion to copper, stainless steel, carbon steel there is not corrosion, to aluminium base nothing corrosion, therefore, it can be applied to the sterilization and the sterilization of medical precision instrument.
In sum, multifunction antiseptic sterilizing cleaning agent composition of the present invention, can be widely used in the processing of human body skin, hand, pet, medical facilities, PE, food industry machine, fruit and vegetable, restaurant vessel, beautifying medical equipment, body building facility, toy for children disinfecting cleaning etc., directly to contact the accurate medical facilities of human body mucous membrane, blood and blood vessel as endoscope, intestines mirror, gastroscope etc. especially suitable for heat labile.
Embodiment
Embodiment 1
Take by weighing raw material by following proportioning:
0.1 kilogram of one chlorine-dihydroxy diphenyl ether;
50 kilograms of dodecyl quaternary ammonium salts;
50 kilograms of chlorohaxanpyridine acetates;
1 kilogram of polyphosphoric acid salt;
300 kilograms of ethanol;
20 kilograms of oxysuccinic acid;
200 kilograms of fatty alcohol-polyoxyethylene ether;
0.1 kilogram of spices;
0.01 kilogram of pigment;
500 kilograms of deionized waters.
At first will chelant compounds, doped quaternary ammonium salt compound, biguanide compound, fat alcohol compound and nonionogenic tenside be put into reactor successively according to formula ratio, the deionized water that adds formula ratio 1/3rd after stirring, start heating unit simultaneously, under 20 ℃ of-90 ℃ of conditions, continue to stir 30-60 minute; Then one chlorine-dihydroxy diphenyl ether is joined in the above-mentioned reaction solution, continued heated and stirred 40-50 minute, stop to stir and heating; With after remaining deionized water adding and stirring 20-30 minute, add organic acid again, add spices and pigment at last, continue stirring and stop after 30-40 minute, left standstill filtration antiseptic sterilizing cleaning agent composition of the present invention promptly 60-120 minute.
Embodiment 2
Take by weighing raw material by following proportioning:
5 kilograms of dichloro-dihydroxy diphenyl ethers;
0.1 kilogram of six alkyl quaternary ammonium salts;
0.2 kilogram of gluconic acid chlorhexidine;
25 kilograms of alkyl diamine tetraacethyls;
10 kilograms of Virahols;
0.1 kilogram in tartrate;
0.1 kilogram of coconut oleoyl amine;
1 kilogram of spices;
0.1 kilogram of pigment
300 kilograms of deionized waters;
Preparation technology is with embodiment 1.
Embodiment 3
Take by weighing raw material by following proportioning:
10 kilograms of trichlorine-dihydroxy diphenyl ethers;
120 kilograms of octadecyl quaternary ammonium salts;
25 kilograms of poly-methyl biguanide hydrochlorides;
50 kilograms in alkyl diamine tetraacethyl sodium;
200 kilograms of ethylene glycol;
30 kilograms of citric acids;
150 kilograms of poly-alkyl-glucosides;
10 kilograms of spices;
5 kilograms of pigment;
700 kilograms of deionized waters;
Preparation technology is with embodiment 1.
Embodiment 4
Take by weighing raw material by following proportioning:
3 kilograms of one chlorine-dihydroxy diphenyl ether;
10 kilograms of dodecyl quaternary ammonium salts;
10 kilograms of chlorohaxanpyridine acetates;
10 kilograms of alkyl diamine tetraacethyls;
50 kilograms of glycerol;
10 kilograms of thionamic acids;
The fatty alcohol-polyoxyethylene ether double centner;
5 kilograms of spices;
3 kilograms of pigment;
700 kilograms of deionized waters;
Preparation technology is with embodiment 1.
Embodiment 5
Take by weighing raw material by following proportioning:
8 kilograms of trichlorine-dihydroxy diphenyl ethers;
80 kilograms of C8-C12 long chain quaternaries;
40 kilograms of poly-methyl biguanide hydrochlorides;
30 kilograms of alkyl diamine tetraacetates;
250 kilograms of propylene glycol;
1 kilogram of lactic acid;
10 kilograms of poly-alkyl-glucosides;
0.5 kilogram of spices;
1 kilogram of pigment;
600 kilograms of deionized waters;
Preparation technology is with embodiment 1.
Claims (10)
1, a kind of multifunction antiseptic sterilizing cleaning agent composition is characterized in that said composition is to be formed by the following substances proportioning:
Chloro-dihydroxy diphenyl ether 0.01%-1%;
Quarternary ammonium salt compound 0.01%-12%;
Biguanide compound 0.02%-5%;
Chelant compounds 0.1%-5%;
Fat alcohol compound 1%-30%;
Organic acid compound 0.01%-3%;
Non-ionic surface compound 0.01%-20%;
Spices 0.01%-1%;
Pigment 0.001%-0.5%;
Deionized water 30%-70%;
Said ratio by weight percentage.
2,, it is characterized in that described chloro-dihydroxy diphenyl ether is a chloro-dihydroxy diphenyl ether, two chloro-dihydroxy diphenyl ethers or three chloro-dihydroxy diphenyl ethers according to the described multifunction antiseptic sterilizing cleaning agent composition of claim 1.
3,, it is characterized in that described quarternary ammonium salt compound is a C6-C18 alkyl quaternary ammonium salt according to the described multifunction antiseptic sterilizing cleaning agent composition of claim 1.
4,, it is characterized in that described quarternary ammonium salt compound is a C8-C12 alkyl quaternary ammonium salt according to the described multifunction antiseptic sterilizing cleaning agent composition of claim 3.
5,, it is characterized in that described biguanide compound is chlorohaxanpyridine acetate, gluconic acid chlorhexidine or poly-methyl biguanide hydrochloride according to the described multifunction antiseptic sterilizing cleaning agent composition of claim 1.
6,, it is characterized in that described chelant compounds is polyphosphoric acid salt, alkyl diamine tetraacethyl or alkyl diamine tetraacetate according to the described multifunction antiseptic sterilizing cleaning agent composition of claim 1.
7,, it is characterized in that described fat alcohol compound is ethanol, Virahol, butanols, ethylene glycol, propylene glycol or glycerol according to the described multifunction antiseptic sterilizing cleaning agent composition of claim 1.
8,, it is characterized in that described organic acid compound is oxysuccinic acid, tartrate, citric acid, lactic acid or amido sulphur according to the described multifunction antiseptic sterilizing cleaning agent composition of claim 1.
9,, it is characterized in that described nonionogenic tenside is fatty alcohol-polyoxyethylene ether, coconut oleoyl amine or poly-alkyl-glucoside according to the described multifunction antiseptic sterilizing cleaning agent composition of claim 1.
10, a kind of preparation method of multifunction antiseptic sterilizing cleaning agent composition as claimed in claim 1, its technological process is:
A. according to formula ratio chelant compounds, doped quaternary ammonium salt compound, biguanide compound, fat alcohol compound and nonionogenic tenside are put into reactor successively, the deionized water that adds formula ratio 1/3rd after stirring, start heating unit simultaneously, under 20 ℃ of-90 ℃ of conditions, continue to stir 30-60 minute;
B. subsequently the chloro-dihydroxy diphenyl ether is joined in the above-mentioned reaction solution, continued heated and stirred 40-50 minute, stop to stir and heating;
C. add the residue deionized water and stirring then after 20-30 minute, add organic acid compound;
D. add spices and pigment at last, stop after restir 30-40 minute;
E. left standstill 60-120 minute, filtration gets final product.
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| Application Number | Priority Date | Filing Date | Title |
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| CN 200410101068 CN1786134A (en) | 2004-12-07 | 2004-12-07 | Multifunction antiseptic sterilizing cleaning agent composition and its preparation method |
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| CN 200410101068 CN1786134A (en) | 2004-12-07 | 2004-12-07 | Multifunction antiseptic sterilizing cleaning agent composition and its preparation method |
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Cited By (11)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN101912085A (en) * | 2010-08-12 | 2010-12-15 | 江苏爱特福84股份有限公司 | Composition for sterilizing fruits and vegetables and preparation method thereof |
| CN101933512A (en) * | 2010-07-05 | 2011-01-05 | 高旭 | Disinfectant capable of being used with high dilution multiples, preparation method and application |
| CN103710970A (en) * | 2013-11-27 | 2014-04-09 | 常熟市琴达针织印染有限公司 | Degerming oil-removal modification treatment finishing agent for clothing |
| CN104031771A (en) * | 2014-06-17 | 2014-09-10 | 滁州斯迈特复合材料有限公司 | Gastroscope cleanser |
| CN104593169A (en) * | 2015-01-20 | 2015-05-06 | 中国日用化学工业研究院 | Disinfectant cleaning agent containing guanidine salt and preparation method of disinfectant cleaning agent |
| WO2015172282A1 (en) * | 2014-05-12 | 2015-11-19 | The Procter & Gamble Company | Liquid anti-microbial laundry detergent composition |
| CN105238580A (en) * | 2015-11-23 | 2016-01-13 | 漯河医学高等专科学校 | Treating agent for cleaning physiology experiment apparatus |
| CN105754735A (en) * | 2016-04-19 | 2016-07-13 | 广州市科士威化妆品制造有限公司 | Kitchen cleaner and preparation method thereof |
| CN106508946A (en) * | 2016-11-30 | 2017-03-22 | 河池市技术开发中心 | Rearing instrument disinfectant containing gluconic acid |
| WO2022133790A1 (en) * | 2020-12-23 | 2022-06-30 | The Procter & Gamble Company | Anti-microbial liquid detergent composition |
| US12091643B2 (en) | 2020-12-23 | 2024-09-17 | The Procter & Gamble Company | Process of removing microorganism from an article of clothing |
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2004
- 2004-12-07 CN CN 200410101068 patent/CN1786134A/en active Pending
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| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN101933512A (en) * | 2010-07-05 | 2011-01-05 | 高旭 | Disinfectant capable of being used with high dilution multiples, preparation method and application |
| CN101912085A (en) * | 2010-08-12 | 2010-12-15 | 江苏爱特福84股份有限公司 | Composition for sterilizing fruits and vegetables and preparation method thereof |
| CN103710970A (en) * | 2013-11-27 | 2014-04-09 | 常熟市琴达针织印染有限公司 | Degerming oil-removal modification treatment finishing agent for clothing |
| WO2015172282A1 (en) * | 2014-05-12 | 2015-11-19 | The Procter & Gamble Company | Liquid anti-microbial laundry detergent composition |
| CN104031771A (en) * | 2014-06-17 | 2014-09-10 | 滁州斯迈特复合材料有限公司 | Gastroscope cleanser |
| CN104593169B (en) * | 2015-01-20 | 2017-12-08 | 中国日用化学工业研究院 | A kind of disinfection cleaning agent containing guanidinesalt and preparation method thereof |
| CN104593169A (en) * | 2015-01-20 | 2015-05-06 | 中国日用化学工业研究院 | Disinfectant cleaning agent containing guanidine salt and preparation method of disinfectant cleaning agent |
| CN105238580A (en) * | 2015-11-23 | 2016-01-13 | 漯河医学高等专科学校 | Treating agent for cleaning physiology experiment apparatus |
| CN105754735A (en) * | 2016-04-19 | 2016-07-13 | 广州市科士威化妆品制造有限公司 | Kitchen cleaner and preparation method thereof |
| CN105754735B (en) * | 2016-04-19 | 2019-08-16 | 广州市科士威化妆品制造有限公司 | A kind of kitchen cleaning agent and preparation method thereof |
| CN106508946A (en) * | 2016-11-30 | 2017-03-22 | 河池市技术开发中心 | Rearing instrument disinfectant containing gluconic acid |
| WO2022133790A1 (en) * | 2020-12-23 | 2022-06-30 | The Procter & Gamble Company | Anti-microbial liquid detergent composition |
| US12091643B2 (en) | 2020-12-23 | 2024-09-17 | The Procter & Gamble Company | Process of removing microorganism from an article of clothing |
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