CN1777406A - 填充了药液的塑料安瓶及其制造方法 - Google Patents

填充了药液的塑料安瓶及其制造方法 Download PDF

Info

Publication number
CN1777406A
CN1777406A CN 200480010684 CN200480010684A CN1777406A CN 1777406 A CN1777406 A CN 1777406A CN 200480010684 CN200480010684 CN 200480010684 CN 200480010684 A CN200480010684 A CN 200480010684A CN 1777406 A CN1777406 A CN 1777406A
Authority
CN
China
Prior art keywords
layer
medicinal liquid
plastics
peace bottle
bottle
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
CN 200480010684
Other languages
English (en)
Other versions
CN100515381C (zh
Inventor
长尾胜美
冈本英志
泉雅满
河上启一
井上富士夫
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Otsuka Pharmaceutical Factory Inc
Original Assignee
Otsuka Pharmaceutical Factory Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Otsuka Pharmaceutical Factory Inc filed Critical Otsuka Pharmaceutical Factory Inc
Publication of CN1777406A publication Critical patent/CN1777406A/zh
Application granted granted Critical
Publication of CN100515381C publication Critical patent/CN100515381C/zh
Anticipated expiration legal-status Critical
Expired - Fee Related legal-status Critical Current

Links

Images

Landscapes

  • Medical Preparation Storing Or Oral Administration Devices (AREA)

Abstract

本发明提供一种具有对气体、水蒸汽、光线的阻隔性和药物透过、吸收、吸附防止功能的填充药液的塑料安瓶及其制备方法。本发明的填充药液用的塑料安瓶10包括容器主体部分11、封闭其开口部位12的熔合部分13和连在其上的扭断用的把持部分14。该安瓶10是使用带有2个以上的层的型坯来形成的，其中至少1个层是具有选自防止气体透过、防止水蒸汽透过、防止光线透过、防止药物透过和防止药物吸收、吸附的至少1种特性的功能性层。即，从多层吹型模具挤出该型坯，在用下方可分模夹住形成容器主体部分11，在其中填充药液15后，用上方可分模夹住开口部位12，制成熔合部分13和把持部分14，从而制得本发明的产品。

Description

填充了药液的塑料安瓶及其制造方法
技术领域
本发明涉及一种塑料制的预先填充了药液的安瓶。更详细的，涉及一种可以防止水蒸汽、水蒸汽以外的气体、光线或药物(药剂、药液、它们的溶剂等)向安瓶内部浸入或向安瓶外部浸出，或者能防止在安瓶内容纳的药剂、药液、溶剂等向安瓶内表面吸收、吸附的填充药液的塑料安瓶及其制造方法。
背景技术
目前，容纳药液的安瓶大多是用玻璃制的。但是玻璃安瓶在容纳的药液pH高时会引起碱性薄片溶解的问题。而且，还有在开封安瓶时手指容易被割伤的问题，和安瓶破损的危险性、开封时产生的碎片混入药液中的危险性等问题。进而，在玻璃安瓶中所含的铝溶解在药液中的危险性也出现在美国食品医药品局(FDA)的警告中。因此，近年来不断用没有上述危险性的塑料制的安瓶来取而代之。
形成安瓶的塑料一般使用有柔软性、且确认安全的聚乙烯(PE)、聚丙烯(PP)等聚烯烃。PE和PP是对酸性和碱性药物非常稳定的材料，但是因为其对氧气、空气、二氧化碳等的吸收、透过性非常高，不适合作为容纳易氧化的药剂、药液的安瓶的形成材料。特别是在小容量的安瓶的情况下，因为伴随水分的透过内容量会减少，会产生药液浓度显著增大的问题。
因此，对于输液袋等薄膜成形制品和输液瓶等吹塑成形制品的成形材料，正在进行各种研究来采用赋予防止气体和水蒸汽透过容器中的能力(阻隔性)的多层体(叠层体)。
塑料的叠层体在薄膜和薄板的制造时广泛采用，但是因为在安瓶的制造中使用薄膜或薄板是不合适的，在安瓶的制造中必然要采用吹塑成形。
根据吹塑成形形成的安瓶记载于专利第2914826号公报和特开昭60-24844号公报。前者记载的安瓶(卫生品用容器)是使用聚环烯烃吹塑成形的制品，后者记载的安瓶(封入注射药剂用的容器)是具有由乙烯-醋酸乙烯酯共聚物(EVA)的皂化产物等制得的防气层作为中间层的制品。
但是，这些文献中只不过记载了仅通过吹塑成形形成安瓶的主题。而且，这些文献中安瓶的密封是通过在注入药液或投入药剂后，用不产生接合的热封来封闭该开口部位，这样来完成密封。这种情况下，会有在形成热封部分时伴随加热多层结构被破坏的担心，其结果会有采用聚环烯烃和EVA的多层结构时伴随而来的防止气体透过等作用、效果受到损害的担心。
另一方面，作为填充药液的塑料安瓶的其他制造方法能列举有所谓的吹塑、填充、封口法(参照特开昭33-8078号公报，特公昭36-5985号公报，rommelag公司的主页“Welcome to rommelag(R)，”“BTS Process-The bottelpack(R)Process”，“2003年3月19日的检索”，互联网<URL；http：//www.rommelag.com/>)。
吹塑、填充、封口法是通过用主模夹住筒状的熔融塑料型坯来形成安瓶本身，接着填充药液后，用头模连续进行安瓶头部的形成和密封，因为安瓶的成形、药液的填充、安瓶的密封是连续进行的，不仅和只用吹塑成形法相比是大不相同的方法，而且可以进一步实现无菌的药液注入，具有可以大量生产的优点。
但是，通过吹塑、填充、封口法制造的安瓶公知的是由PE和PP等聚烯烃制备的单层体。因而，现有情况是对于通过吹塑、填充、封口法制造多层结构的安瓶，以及形成该叠层结构的1层对于气体、水蒸汽、光线和药物的防止透过的能力(阻隔性)和对药物的吸收吸附的防止能力都没有任何的相关研究(参照特公昭33-8078号公报、特公昭36-5985号公报、前述的rommelag公司的主页、mutual公司的主页(“包装设备-容器成形无菌填充系统”、“2003年3月19日检索”、互联网<URL；http：//www.mutual.co.jp>)、日新制药公司的主页(“聚乙烯瓶”、“2003年3月19日检索”、互联网<URL；http：//www.yg-nissin.co.jp/BFS.htm>))。
为了赋予对气体、水蒸汽、光线和药物的防止透过(阻隔性)、对药物吸收吸附的防止能力，考虑有例如在具有耐气体透过性的袋中容纳保存安瓶，或用具有防止光线透过能力(光线阻隔性)的材料覆盖安瓶表面，或进行外包装的方法。但是这些方法必须分开使用容纳袋和覆盖表面的材料，因而制造步骤变得复杂，会有制造成本上升等问题。
发明内容
本发明的目的在于提供能防止水蒸汽、水蒸汽以外的气体、光线或药物向安瓶内部浸入或向安瓶外部浸出，或者在安瓶内容纳的药剂、药液、溶剂等向安瓶内表面的吸收吸附的药液填充塑料安瓶及其制造方法。
为了解决上述课题，本发明的填充药液塑料安瓶的特征如下，其具有柔软性的容器主体部分、封闭该容器主体部分的开口部位的熔合部分和连在该熔合部分上扭断熔合部分用的把持部分，上述容器主体部分、熔合部分和把持部分是用具有2层或以上的筒状型坯一体成形制得的，上述容器主体部分是用可分模夹住上述型坯成形，在其内部填充药液，然后封闭开口部位来制得的，并且上述型坯的至少1层为具有选自防止气体透过、防止水蒸汽透过、防止光线透过、防止药物透过和防止药物吸收吸附的能力的至少1种特性的功能性层。
根据上述填充药液的塑料安瓶，因为在安瓶的制造中采用吹塑、填充、封口法，可以在无菌条件下实现药液的注入、密封。另外，上述本发明的填充药液用塑料安瓶与通过向吹塑成形形成的中空的安瓶中填充药剂后，以不产生接合的方式熔合开口部位来制备的产品(参照专利第2914826号公报或特开昭60-24844号公报中的记载)不同，在开口部位的熔合处，不会有层构成受到破坏的担心。因此，本发明的填充药液塑料安瓶还可以充分发挥安瓶成形后所期望的特性(气体阻隔性等)。
本发明的功能性层所要求的特性可列举有防止气体透过(气体阻隔性)、防止水蒸汽透过(水蒸汽阻隔性)、防止光线透过(光线阻隔性)、防止药物透过(药物阻隔性)和防止药物吸收吸附的能力。这些特性如下所述根据作为型坯中功能性层使用的部分中的塑料材料和其配混剂的种类来决定。
另外，在特开2001-70399号公报中记载了可以扭断把持部分来开封的填充药液的塑料安瓶，进而记载了该安瓶可以用吹塑、填充、封口法制造的主题和可以根据需要多层化、或赋予其遮光性的主题(段[0007]、[0012])。但是，该公报中对关于多层化型坯本身，或通过在型坯中混合具有上述功能的材料制得的层而赋予安瓶整体期望的阻隔性没有任何具体的记载和建议。
本发明的填充药液塑料安瓶在其成形中所用的型坯的最内层优选通过含有聚烯烃或聚环烯烃的树脂来形成。
通过用含有聚烯烃或聚环烯烃的树脂作为型坯的最内层，填充药液用塑料安瓶的最内层也可以是使用含有聚烯烃或聚环烯烃的树脂制得的层。聚烯烃和聚环烯烃是稳定的、安全性得到确认的材料，因而在其最内层设置聚烯烃或聚环烯烃制得的填充药液用塑料安瓶适合用作医疗用容器。
本发明的填充药液用塑料安瓶，其成形中使用的型坯是除了最内层至少有1层是混合了选自着色剂、紫外线吸收剂和氧吸收剂的至少1种药剂制得的层，并且比该层更内侧的层优选是具有防止药物透过能力的层。
将除了型坯最内层的至少1层制成混合着色剂和/或紫外线吸收剂来形成的层，由此可以赋予填充药液用塑料安瓶以防止光线透过能力(光线阻隔性，具体来说是对光、紫外线等的阻隔性)。而且，通过将除了型坯最内层的至少1层制成混合氧吸收剂来形成的层，由此能赋予填充药液用塑料安瓶以防止氧气透过能力(氧气阻隔性)。
混合了着色剂、紫外线吸收剂或氧吸收剂制得的层在和药液等直接接触时会有其内部所含的着色剂等溶出的担心。但是，根据上述的填充药液塑料安瓶，因为在混合了着色剂等的层内侧设置了具有防止药物透过能力的层，可以防止产生着色剂等溶解在安瓶容纳的药液中这样的问题。
作为在混合了上述着色剂等的层内侧设置的、具有防止药物透过能力的层能列举有后述的多元醇层、聚酯层和聚环烯烃层。
本发明的填充药液用塑料安瓶，其成形中所用的型坯的功能性层优选为
(i)含有聚酰胺层的制品，
(ii)含有多元醇层的制品，
(iii)含有聚酯层的制品，或者
(iv)含有聚环烯烃层的制品。
制备含有上述(i)的聚酰胺层的功能性层时，能赋予填充药液用塑料安瓶防止气体透过和防止水蒸汽透过的能力。因而，该安瓶可以适合于容纳例如易氧化、在氧气存在下不能保存的药液和由于水分含量的变化药效等发生显著变化的药液。
制备含有上述(ii)的多元醇层的功能性层时，能赋予填充药液用塑料安瓶防止气体透过、防止水蒸汽透过、防止药物透过和防止药物吸收吸附的能力。因而，该安瓶可以适合用于容纳例如在氧气存在下不能保存的药液和由水分含量的变化药效等能发生显著变化的药液。
例如，在安瓶带有含着色剂、紫外线吸收剂、氧吸收剂等药剂的层时，通过在该层内侧设置多元醇层，可以防止上述试剂溶解在安瓶内填充的药液中。
制备含有上述(iii)的聚酯层的功能性层时，能赋予填充药液用塑料安瓶防止气体透过、防止水蒸汽透过、防止药物透过和防止药物吸收吸附的能力。因而，该安瓶可以适合用于容纳例如在氧气存在下不能保存的药液和由水分含量的变化药效等能发生显著变化的药液。而且，通过使用聚酯层作为安瓶的最内层，可以防止药物向安瓶最内层的吸收或吸附。
聚环烯烃因为具有防止药剂吸收、吸附的能力、防止药物透过的能力(药物阻隔性)、防止水蒸汽透过的能力，并且透明性优良，已经有尝试将其用于医疗用容器的形成材料(特开平5-277154号公报)。因而，制备含有上述(iv)的聚环烯烃层的功能性层时，能赋予填充药液用塑料安瓶防止药物透过(药物阻隔性)、防止药物吸收吸附、防止水蒸汽透过的能力。
而且，例如，在安瓶带有含着色剂、紫外线吸收剂、氧吸收剂等药剂的层时，通过在该层内侧设置聚环烯烃层，可以防止上述试剂溶出到填充在安瓶内的药液中。
使用聚环烯烃层作为安瓶最内层时，可以防止药物对安瓶最内层的吸收或吸附。进而，这种情况下，作为形成最内层的聚环烯烃优选使用玻璃化转变温度(Tg)为110℃或以下的产品。通过在最内层使用玻璃化转变温度在上述范围的聚环烯烃，对于用吹塑、填充、封口法的成形模的接合(主模和头模的接合)部分，能防止在内容液填充、密封后产生液漏。聚环烯烃的玻璃化转变温度在上述范围内特别优选60～105℃，更优选为60～80℃。
另外，在特开平5-293159号公报中记载了使用聚环烯烃成形的安瓶的例子，但是该文献中对于用吹塑、填充、封口法制造安瓶没有任何记载，对于上述液漏问题的产生及其解决方法液没有教导和暗示。
顺便说一下，聚环烯烃的玻璃化转变温度超过110℃的话，一般具有缺乏对弯曲应力的耐性、本身较脆的特征。因而，使用具有用玻璃化转变温度在110℃或以下的聚环烯烃制备的最内层和含有玻璃化转变温度超过110℃的聚环烯烃的层的多层体来形成填充药液用塑料安瓶，可以防止在内容液的填充、密封后产生液漏，并且通过弯曲或扭曲安瓶的熔合部分(薄的地方)等，可以容易地进行安瓶的开封操作。
另外，用非环状的烯烃制得的聚合物一般和聚环烯烃相比，其成形体的柔软性更高，耐冲击性优良。因而，当形成塑料安瓶的层合体不仅具有含环状烯烃的层，还具有含非环状聚烯烃的层时，能提高塑料安瓶整体的抗冲击性。
本发明的填充药液塑料安瓶也可以是用可折断的薄部分连接的多个安瓶的连接体，制备这样的连接体例如可以容易地进行容纳同种药液的多个安瓶的管理。
本发明的填充药液塑料安瓶在功能性层为具有防止水蒸汽透过或防止药物吸收吸附能力的层时，可以用作内容量为0.5～20mL的安瓶。即，对于具有上述(i)的聚酰胺层、上述(ii)的多元醇层、上述(iii)的聚酯层或上述(iv)的聚环烯烃层作为功能性层的塑料安瓶来说，适合用于内容量为0.5～20mL的小容量安瓶。内容量为0.5～20mL的安瓶因其容纳溶液的绝对量少，在安瓶容纳期间伴随溶剂的挥发、或药剂被吸收吸附到安瓶上，会产生所谓的容纳溶液的性状显著变化的问题，通过设置防止水蒸汽透过、防止药物吸收吸附能力等优良的聚酰胺层、多元醇层、聚酯层或聚环烯烃层等，可以防止该问题的发生。
本发明的填充药液用塑料安瓶的制造方法其特征在于包括下列步骤：用容器主体部分成形用的下方可分模夹住带有2个或以上的层的筒状型坯，其中至少1个层是具有选自防止气体透过、防止水蒸汽透过、防止光线透过、防止药物透过和防止药物吸收、吸附的至少1种特性的功能性层，在筒状型坯的内部形成空洞来成形容器主体部分后，
在该容器主体部分内填充药液，接着，
用上方可分模夹住该容器主体部分的开口部位，形成封闭该开口部位的熔合部分和与该熔合部分相连用于扭断熔合部分的把持部分。
根据上述制造方法，可以在无菌条件下实现向填充药液用塑料安瓶内注入、密封药液。而且，在填充药液后，熔合封闭安瓶的开口部位时，可以不破坏多层塑料的层结构，形成熔合部分。
因而，上述的本发明的制造方法非常适合于制造能防止气体、水蒸汽、光线和药剂向内部或外部透过、或安瓶内的药剂、药液、溶剂等向内表面吸收或吸附的填充药液用塑料安瓶。
本发明的填充药液用塑料安瓶的制造方法中的型坯优选使用(a)其最内层由含有聚烯烃或聚环烯烃的树脂来形成，或者(b)除了其最内层的至少1层为混合了选自着色剂、紫外线吸收剂和氧吸收剂的至少1种药剂的层，且该层内侧的层为具有防止药物透过能力的层。
上述(a)的情况下，通过上述方法得到的填充药液用塑料安瓶能更安全地制作医疗用容器。
上述(a)中，最内层是由含有聚环烯烃的树脂形成的情况下，根据与上述相同的理由，作为该聚环烯烃优选使用玻璃化转变温度在110℃或以下的产品，更优选使用玻璃化转变温度为60～105℃的产品。
而且，上述(a)的情况下，根据与上述相同的理由，作为型坯优选使用具有由玻璃化转变温度在110℃或以下的聚环烯烃形成的最内层和由玻璃化转变温度超过110℃的聚环烯烃形成的层的产品。
上述(b)的情况下，能赋予由上述方法得到的填充药液用塑料安瓶以防止光线透过能力(对光、紫外线等的阻隔性)。
附图的简要说明
图1是表示本发明的填充药液用塑料安瓶的一个实施方式的部分截面图，(a)是正面图，(b)为右侧面图。
图2是表示本发明的填充药液用塑料安瓶的其他实施方式的部分截面正面图。
具体实施方式
接着参照附图详细说明本发明的填充药液用塑料安瓶及其制备方法。
<填充药液用塑料安瓶>
图1和图2是表示本发明的填充药液用塑料安瓶的一个实施方式的附图。
图1中所示的填充药液用塑料安瓶10具有柔软性的容器主体部分11、和封闭容器主体部分开口部位12的熔合部分13、连在熔合部分13上的把持部分14。
图2中所示的填充药液用塑料安瓶18和图1所示的安瓶10一样，具有柔软性的容器主体部分11、和封闭容器主体部分开口部位12的熔合部分13、连在熔合部分13上的把持部分14。对于该安瓶18，在侧边缘部分17之间通过可以扭断的连接部分19连接。
填充药液用塑料安瓶的把持部分14能通过弯曲或扭曲从熔合部分13分离。扭断把持部分14，使其从熔合部分13和容器主体部分11分离，这样可以使容器主体部分11的开口部分12打开，能获取、排出容器主体部分11内密封、填充的药液15。
另外，形成安瓶10、18的多层体具有含玻璃化转变温度超过110℃的聚环烯烃的层时，根据前述理由，可以从熔合部分13简易地进行分离操作。
形成填充药液用塑料安瓶的塑料16其特征为其至少1层为具有选自防止气体透过、防止水蒸汽透过、防止光线透过、防止药物透过和防止药物吸收吸附能力的至少1种特性的功能性层。
填充药液用塑料安瓶的侧边缘部分17为通过该安瓶的吹塑、填充、封口法成形时，用模头夹入型坯来形成。填充药液用塑料安瓶18例如可以使用带有与连接的安瓶的数目相应的模头和模具的多头式模头来成形。
<安瓶成形材料>
对于本发明的填充药液用塑料安瓶，在该安瓶中含有的功能性层如上所述具有下列特征，其具有选自防止气体透过、防止水蒸汽透过、防止光线透过、防止药物透过和防止药物吸收吸附能力的至少1种特性。关于该特性与在该功能性层中使用的塑料材料的种类的对应，如上所述。
作为本发明中可以使用的聚酰胺在此没有限制，能列举有例如尼龙-6、尼龙-6，6、尼龙-6，12、尼龙-12、苯二甲基二胺聚酰胺等。
作为本发明中可以使用的聚酯在此没有限制，但是能列举有例如聚对苯二甲酸乙二酯(PET)、聚萘二甲酸乙二酯、聚对苯二甲酸丁二酯(PBT)等。
作为本发明中可以使用的多元醇在此没有限制，但是能列举有例如聚乙烯醇(PVOH)、乙烯-乙烯醇共聚物(EVOH)等。
作为本发明中可以使用的聚环烯烃在此没有限制，可以列举有乙烯和二环戊二烯类的共聚物、乙烯和降冰片烯类化合物的共聚物、环戊二烯衍生物的开环聚合物、多个环戊二烯衍生物的开环共聚物及其氢化产物等。
本发明中，上述例举的聚环烯烃中特别优选使用乙烯和降冰片烯类化合物的共聚物的加氢产物、或者1种或以上的环戊二烯衍生物的开环(共)聚合物的加氢产物。通过使用该聚环烯烃，能制备安瓶强度和防止水分透过能力更好的层，而且还能赋予安瓶防止气体透过的能力。
对于上述聚环烯烃，能列举有例如具有用通式(1)表示的重复单元和通式(1’)表示的重复单元的聚合物，具有用通式(2)表示的重复单元的聚合物。
Figure A20048001068400141
(式(1)和式(1’)中，R1、R1’、R2和R2’可以相同或不同，表示氢、烃残基或卤素、酯基、硝基、吡啶基等极性基团。R1、R1’、R2和R2’也可以相互结合成环。m和m’为1或1以上的整数，n和n’为0或1或1以上的整数。)
Figure A20048001068400151
(式(2)中，R3和R4可以相同或不同，表示氢、烃残基或卤素、酯基、硝基、吡啶基等极性基团。R3和R4也可以相互结合成环。x和z为1或1以上的整数，y为0或1或1以上的整数。)
具有通式(1)和(1’)表示的重复单元的聚合物是通过公知的开环聚合方法聚合1种或2种或其以上的单体，或者接着用常规方法将这样得到的开环聚合物加氢制得的产品。作为该聚合物的具体例子能列举有日本ゼオン公司制造的商品名为“ゼオノア(注册商标)”、日本合成橡胶公司制造的商品名为“ARTON(注册商标)”等的商品。
具有通式(2)表示的结构单元的聚合物是通过公知的方法加成共聚作为单体的1种或2种或其以上的降冰片烯系单体和乙烯，和/或将其用常规方法加氢制备的产品。作为该聚合物的具体例子能列举有三井化学公司制造的商品名为“アペル(注册商标)”、テイコナGmbH公司制造的商品名为“トパス(注册商标)”等的商品。
具有上述通式(1)、(1’)和(2)表示的重复单元的聚合物中，因为其加氢产物的任何一种都是饱和的聚合物，其除了有气体遮蔽性和水分遮蔽性以外，从耐热性和透明性、进一步从稳定性来看也优良。
本发明中使用的聚环烯烃的熔体流动指数(MFR)从安瓶的成形性和成形制品的力学特性等观点来看优选4～30g/10分钟(190℃)。
本发明中使用的聚环烯烃的分子量没有特别限制，但是数均分子量(Mn)优选1万～10万，更优选2万～5万。需要说明的是，分子量例如可以通过环己烷作溶剂的凝胶渗透色谱法(GPC)分析来测定。
本发明中，作为可以在功能性层的成形中使用的树脂除了上述例子以外，还能列举有例如改性聚烯烃、聚偏氯乙烯(具有防止气体透过、防止水蒸汽透过的能力)、聚丙烯腈(具有防止气体透过、防止水蒸汽透过、防止药物透过、防止药物吸收吸附的能力)等。
作为改性的聚烯烃能列举有在非极性聚合物聚乙烯或聚丙烯等聚烯烃中加成羧基等官能团的产物(例如接枝聚合马来酸等不饱和羧酸的改性聚烯烃等)等。具体的例子有例如三井化学公司制造的粘接性聚烯烃[商品名“アドマ-(R)LB540”、“アドマ-(R)NF510”、“アドマ-(R)UF300”等]；三菱化学公司制造的高粘接性树脂[商品名“モデイツク-AP(R)P512V”、“モデイツク-AP(R)L103”等]等。这些改性聚烯烃可以根据粘附层的树脂种类来适宜地选择。
在具有防止光线透过能力(光线阻隔性)的层的形成中，可以在塑料中混合下述颜料、紫外线吸收剂。作为在光线阻隔性材料的形成中使用的颜料在此没有限制，能列举有例如氧化钛、氧化锌、碳黑、铁红、二氧化硅等无机颜料和酞菁系、偶氮系、喹吖酮系有机颜料等。
另一方面，作为在光线阻隔性材料的形成中使用的紫外线吸收剂在此没有限制，能列举有例如水杨酸苯酯、水杨酸p-辛基苯酯等水杨酸系紫外线吸收剂；2，4-羟基二苯甲酮、双(2-甲氧基-4-羟基-5-苯并基苯基)甲烷等二苯甲酮系紫外线吸收剂；2-乙基己基-2-氰基-3，3-二苯基丙烯酸酯和乙基-2-氰基-3，3-二苯基丙烯酸酯等氰基丙烯酸酯系紫外线吸收剂；2-(5-甲基-2-羟基苯基)苯并三唑、2-(3-叔丁基-5-甲基-2-羟基苯基)-5-氯代苯并三唑等苯并三唑系等。上述颜料或紫外线吸收剂在构成光线阻隔性层的塑料中优选以0.01～5重量％左右来添加。
具有防止气体透过能力(气体阻隔性)的层中，特别是具有氧气阻隔性的层的形成中，可以在塑料中混合铁、亚硫酸氢钠、亚硫酸钠、邻苯三酚、抗坏血酸、生育酚等氧吸收剂。氧吸收剂在形成氧气阻隔性层的塑料中优选以0.15～5重量％左右来添加。
对于本发明中填充药液用的塑料安瓶，除了该功能性层以外的层一般使用聚烯烃来形成是适合的。作为该聚烯烃能列举有聚乙烯、聚丙烯等现有医疗用塑料容器中所用的各种聚烯烃。而且，根据需要在层间还可以混合不饱和羧酸改性聚乙烯、乙烯-丙烯酸共聚物、乙烯-醋酸乙烯酯共聚物等粘接性树脂。对于形成这些其他层的塑料，配合层结构和容器的形状等，密度、MFR等性状能在较宽范围内适宜选择。
本发明中可以使用的聚烯烃没有特别限制，可以采用目前公知的各种聚烯烃。另外，在各种聚烯烃中特别优选使用聚乙烯或聚丙烯。
在聚乙烯(PE)中，可以使用所谓的高压法(支链状)低密度聚乙烯(HP-LDPE)、直链状低密度聚乙烯(LLDPE)、中密度聚乙烯(MDPE)、高密度聚乙烯(HDPE)等各种PE。PE的密度可以在0.900g/cm3～0.965g/cm3的PE塑料的一般范围内适宜选择。从与用聚环烯烃制得的层的成形性或安瓶的力学特性等观点考虑，优选在比较低密度的范围内，具体为0.910～0.930g/cm3的范围内选择。PE的熔体流动指数(MFR)从用聚环烯烃制得的层的成形性和安瓶的力学特性等观点来考虑优选为0.2～20g/10分钟(190℃)。
PE不限于均聚物，也可以是共聚物。此时作为共聚单体优选1-丁烯、1-戊烯、1-己烯、4-甲基-1-戊烯、1-辛烯、1-癸烯等α-烯烃类。共聚单体的含量比例优选在20摩尔％或以下，更优选在3～20摩尔％左右。
聚丙烯(PP)的种类、性质也没有特别限制，作为PP采用一般的全同立构PP或间规PP(即结晶性均聚物)、或者以其作主要成分的结晶性共聚物是适合的。该结晶性共聚物中的共聚单体优选为乙烯、1-丁烯等α-烯烃类。共聚单体的含有比例优选在30摩尔％或以下，更优选为2～30摩尔％左右，进一步优选为3～25摩尔％左右。PP的熔体流动指数(MFR)从与用聚环烯烃制得的层的成形性和安瓶的力学特性等观点来考虑优选为0.2～20g/10分钟(190℃)。
为了赋予本发明的塑料安瓶防止氧气透过的能力(氧气阻隔性)，可以在塑料中混合铁、亚硫酸氢钠、亚硫酸钠、邻苯三酚、抗坏血酸、生育酚等氧吸收剂。氧吸收剂在形成氧气阻隔性层的塑料中优选以0.15～5重量％左右的量来添加。而且，形成本发明的塑料安瓶的塑料中可以适宜适量地混合丁基羟基甲苯、八癸基-3-(3，5-二叔丁基-4-羟基苯基)丙酸酯等稳定剂；银-沸石、扁柏油酚等抗菌剂；苯二甲酸酯等增塑剂等。在使用混合这些添加剂的塑料的情况下，优选将安瓶制成多层体，且将混合了上述添加剂的塑料层制成内壁面以外的层。
<安瓶的层结构>
本发明的填充药液的塑料安瓶的最内层优选使用以聚乙烯或聚丙烯为代表的聚烯烃或聚环烯烃。聚烯烃或聚环烯烃如上所述要有对药剂、药液的安全性和稳定性，进而要求溶合性也优良。
具有防止药物透过能力(药物阻隔性)的层设置在塑料安瓶的最内层外侧，且在其他功能性层的内侧，能充分发挥药物阻隔性层的作用效果，所以优选。
<混合剂等>
形成本发明的填充药液用塑料安瓶的塑料根据需要也可以混合。而且，根据需要可以适宜适量地混合丁基羟基甲苯、八癸基-3-(3，5-二叔丁基-4-羟基苯基)丙酸酯等稳定剂；银-沸石、扁柏油酚等抗菌剂；苯二甲酸酯等增塑剂等。
对于混合这样的添加剂制得的层优选设置在药物阻隔性层的外侧。
<制造方法等>
本发明的填充药液用塑料安瓶可以使用带有多层挤出机和多层吹模的吹塑、填充、封口机来制造。
具体来说，首先使用多层吹模通过挤出成形形成有2个以上层的筒状型坯。该型坯中至少1层使用具有选自防止气体透过(气体阻隔性)、防止水蒸汽透过(水分阻隔性)、防止光线透过(光学阻隔性)、防止药物透过(药剂阻隔性)和防止药物吸收吸附的能力的至少1种特性的功能性层。接着，用容器主体部分成形用的下方可分模夹住该筒状型坯，将空气压入其内部，或者以模面孔吸引型坯来形成容器主体部分，在该容器主体部分填充规定和规定量的药液。进而，用上方可分模夹住该容器主体部分的开口部，通过形成封闭该开口部位的熔合部分和连在该熔合部分上的扭断熔合部分用的把持部分，可以制造本发明的填充药液用塑料安瓶。型坯的层结构可以根据填充药液的塑料安瓶所要求的层结构来适宜设定。
根据吹塑、填充、封口法的安瓶制造条件没有特别限制，可以根据通常的制造条件。型坯的熔融挤出温度或熔融挤出速度可以根据所用的树脂和目的容器的形状等适宜设定。
填充药液的塑料安瓶的总厚度优选300～2000μm左右。功能性层的厚度没有特别限制，可以根据该层所具有的功能的种类和使用目的等来适宜选择，通常优选为10～300μm左右。
<可以容纳的药剂、药液>
本发明的塑料安瓶中容纳的药液没有特别限制，可以根据功能性层具有的功能特性来适宜选择。
例如对于易氧化药剂的溶液，本发明的塑料安瓶中，可以用带有防止气体透过能力(气体阻隔性)的层的制品来容纳。作为易氧化药剂能列举有例如维生素A等维生素类；半胱氨酸、色氨酸等氨基酸；还原型谷胱甘肽、脂肪乳剂、脂质体制剂等。
对于光劣化药剂的溶液，本发明的安瓶中，可以用带有防止光线透过能力(光线阻隔性)的层的制品来容纳。作为光劣化性药剂能列举有例如维生素B2、维生素B12等维生素类；盐酸必消痰、含糖氧化铁剂、硫酸阿托品、新斯的明、二甲基氨基丙酰氨基安替比林、氟哌啶醇、盐酸麻黄素等。
对于吸收吸附性药剂的溶液，本发明的安瓶中可以用带有防止药物吸收吸附能力的层的制品来容纳。作为吸收吸附性药剂能列举有例如维生素D等维生素类；硝化甘油；依降钙素(elcatonin)等。
[实施例]
接着列举实施例来说明本发明的药液填充用的塑料安瓶。
对于药液填充用的塑料安瓶的形成材料，在下面示出其简称、物性等。
(聚烯烃)
·PE1：乙烯·1-丁烯共聚物(密度0.92g/cm3、熔体流动指数(MFR)1.0g/10min(190℃)，商品名“ウルトゼツクス2010B”，三井化学公司制造)
·PE2：在PE1中每份各混合0.2重量％的有机颜料(商品名“クロモフタルイエロ-GR”和“クロモフタルイエロ-AGR”，都是チバガイギ-公司制造的)的制品。(具有防止紫外线透过功能(紫外线阻隔性)的塑料)
·PE3：在PE1中混合10重量％的作为氧吸收剂的亚硫酸钠(平均粒径为约8μm)的制品。(具有防止氧气透过功能(氧气阻隔性)的塑料)
·PP1：等规聚丙烯(密度0.91g/cm3，MFR1.6g/10min(230℃)，品号“J704”，三井化学公司制造)
·PP2：在PP1中每份各混合0.2重量％的有机颜料(商品名“クロモフタルイエロ-GR”和“クロモフタルイエロ-AGR”)的制品。(具有防止紫外线透过功能的塑料)
(改性聚烯烃)
·AD1：马来酸改性聚乙烯(密度0.92g/cm3，MFR0.9g/10min(190℃)，商品名“アドマ-NB550”，三井化学公司制造)
(多元醇)
·EVOH1：乙烯·乙烯醇共聚物(熔点175℃，MFR1.6g/10min(190℃)，商品名“エバ-ルEP-H101”，クラレ公司制造)
(聚环烯烃)
·COP1：降冰片烯系单体的开环聚合物加氢产物(比重1.01，MFR20g/min(280℃)，玻璃化转变温度(Tg)105℃，商品名“ゼオノア1020R”，日本ゼオン公司制造)
·COP2：降冰片烯系单体的开环聚合物加氢产物(比重1.01，MFR27g/min(280℃)，Tg为70℃，商品名“ゼオノア750R”，日本ゼオン公司制造)
·COP3：降冰片烯系单体的开环聚合物加氢产物(比重1.01，MFR20g/min(280℃)，Tg为136℃，商品名“ゼオノア1420R”，日本ゼオン公司制造)
·COC1：乙烯和四环十二烯的共聚物(比重1.03，MFR25g/10min(260℃)，Tg为105℃，商品名“アペルAPL6011T”，三井化学公司制造)
·COC2：乙烯和四环十二烯的共聚物(比重1.02，MFR40g/10min(190℃)，Tg为80℃，商品名“アペルAPL6509”，三井化学公司制造)
·COC3：乙烯和四环十二烯的共聚物(比重1.02，MFR40g/10min(190℃)，Tg为70℃，商品名“アペルAPL8008”，三井化学公司制造)
(聚酰胺)
·NY1：间二甲苯二胺-己二酸缩聚物(熔点243℃，商品名“MX尼龙6001”，三菱瓦斯化学公司制造)
(聚酯)
·PET1：聚对苯二甲酸乙二酯(商品名“三井PET”，三井化学公司制造)
<填充药液的塑料安瓶的制造>
(实施例1)
使用带有2层吹模的吹塑、填充、封口机，由COP1(聚环烯烃)制备内层、PE1(聚烯烃)制备外层，且在其内部填充0.005％的硝化甘油水溶液10mL，制造有2层结构的填充药液用塑料安瓶(内容积10mL)。该安瓶10具有图1所示的形状，管壁厚为内层100μm，外层700μm。
(实施例2)
使用带有2层吹模的吹塑、填充、封口机，由COP1(聚环烯烃)和PE1(聚烯烃)以50∶50(重量比)的比例混合的塑料制备内层、PP1(聚烯烃)制备外层，且在其内部填充0.005％的硝化甘油水溶液20mL，制造有2层结构的填充药液用塑料安瓶(内容积20mL)。该安瓶10具有图1所示的形状，管壁厚为内层100μm，外层700μm。
(实施例3)
使用带有3层吹模的吹塑、填充、封口机，由PE1(聚烯烃)制备内层、COP1(聚环烯烃)制备中间层、PE1制备外层，且在其内部填充0.005％的硝化甘油水溶液10mL，制造有3层结构的填充药液用塑料安瓶(内容积10mL)。该安瓶10具有图1所示的形状，管壁厚为内层50μm，中间层100μm，外层700μm。
(实施例4)
作为形成中间层的塑料，使用COP1和PE1(聚烯烃)以50∶50(重量比)的比例混合的塑料来代替只使用COP1(聚环烯烃)，安瓶的内容积为5mL，且在安瓶中填充的0.005％硝化甘油水溶液的量为5mL，除此以外进行和实施例3相同的操作，制造具有3层结构的填充药液用塑料安瓶。
(实施例5)
使用带有5层吹模的吹塑、填充、封口机，由PE1(聚烯烃)制备内层、COP1(聚环烯烃)和PE1以50∶50(重量比)的比例混合的塑料制备中间层(内层侧)、COP1制备中间层(中间部)、COP1和PE1以50∶50(重量比)的比例混合的塑料制备中间层(外层侧)和PE1制备外层，且在其内部填充0.005％的硝化甘油水溶液20mL，制造有5层结构的填充药液用塑料安瓶(内容积20mL)。该安瓶10具有图1所示的形状，管壁厚为内层50μm，中间层(内层侧、中间层和外层侧)各为100μm，外层700μm。
(实施例6)
作为形成中间层(中间部)的塑料，使用COP1和PE1(聚烯烃)以80∶20(重量比)的比例混合的塑料代替只用COP1(聚环烯烃)，安瓶的内容积为10mL，且在安瓶内部填充的0.005％的硝化甘油水溶液的量为10mL，除此以外进行和实施例5相同的操作，制造具有5层结构的药液填充用塑料安瓶。
<塑料安瓶的性能评价>
对实施例1～6的填充药液用塑料安瓶分别在106℃下实施高压蒸气灭菌40分钟，然后在60℃下保存2周，测定在安瓶内填充的硝化甘油水溶液的硝化甘油的含量。测定结果、塑料安瓶的层结构等一并示于表1中。另外，硝化甘油是吸收、吸附性高的药剂。
任何一个安瓶的测定结果都是保存2周后的硝化甘油的残存量为95重量％以上，硝化甘油向安瓶内壁面的吸收、吸附和向安瓶外部的浸透、排出也明显得到了充分的抑制。即，实施例1～6的安瓶任何一个的防止药物吸收吸附和防止药物透过的能力都良好。这认为是因为实施例1～6的安瓶都有聚环烯烃层。
<表1>
上面：物质    中间：树脂的混合比例(重量比)    下面：层厚度
  内层                        中间层   外层   容积(mL)
  内层侧   中间部   外层侧
  实施例1   COP1100μm   -   -   -   PE1700μm   10
  实施例2   COP1+PE1(50∶50)100μm   -   -   -   PP1700μm   20
  实施例3   PE150μm   -   COP1100μm   -   PE1700μm   10
  实施例4   PE150μm   -   COP1+PE1(50∶50)100μm   -   PE1700μm   5
  实施例5   PE150μm   COP1+PE1(50∶50)100μm   COP1100μm   COP1+PE1(50∶50)100μm   PE1500μm   20
  实施例6   PE150μm   COP1+PE1(50∶50)100μm   COP1+PE1(80∶20)100μm   COP1+PE1(50∶50)100μm   PE1500μm   10
<填充药液的塑料安瓶的制造>
(实施例7)
使用带有3层吹模的吹塑、填充、封口机，由PE1(聚烯烃)制备内层、EVOH1(多元醇)制备中间层、PE1制备外层，且在其内部填充0.1％的色氨酸水溶液10mL，制造有3层结构的填充药液用塑料安瓶(内容积10mL)。该安瓶10具有图1所示的形状，管壁厚为内层50μm，中间层100μm，外层700μm。
(实施例8)
使用带有5层吹模的吹塑、填充、封口机，由PE1(聚烯烃)制备内层、AD1(改性聚烯烃)制备中间层(内层侧)、EVOH1(多元醇)制备中间层(中间部)、AD1制备中间层(外层侧)和PE1制备外层，且在其内部填充0.1％的色氨酸水溶液5mL，制造有5层结构的填充药液用塑料安瓶(内容积5mL)。该安瓶10具有图1所示的形状，管壁厚为内层50μm，中间层(内层侧和外层侧)各为10μm，中间层(中间部)为100μm，外层700μm。
(实施例9)
使用带有4层吹模的吹塑、填充、封口机，由PE1(聚烯烃)制备内层、PE3(有氧气阻隔性的塑料)制备中间层(内层侧)、EVOH1(多元醇)制备中间层(外层侧)和PE1制备外层，且在其内部填充0.1％的色氨酸水溶液10mL，制造有4层结构的填充药液用塑料安瓶(内容积10mL)。该安瓶10具有图1所示的形状，管壁厚为内层50μm，中间层(内层侧和外层侧)各为100μm，外层600μm。
<塑料安瓶的性能评价>
对实施例7～9的填充药液用塑料安瓶分别在106℃下实施高压蒸气灭菌40分钟，然后在60℃下保存2周，测定在安瓶内填充的色氨酸水溶液的色氨酸的含量。测定结果、塑料安瓶的层结构等一并示于表2中。另外，色氨酸是易氧化的药剂。
任何一个安瓶的测定结果都是在保存2周后色氨酸的残存量为95重量％以上，表明色氨酸的氧化劣化得到了充分的抑制。即，表明实施例7～9的安瓶任何一个的防止气体透过(气体阻隔性，特比是氧气阻隔性)和防止药物透过的能力都良好。这认为是因为实施例7～9的安瓶都有多元醇层。
<填充药液的塑料安瓶的制造>
(实施例10)
使用带有3层吹模的吹塑、填充、封口机，由PE1(聚烯烃)制备内层、COP1(聚环烯烃)制备中间层、PE2(紫外线阻隔性塑料)制备外层，且在其内部填充0.05％的维生素B2水溶液10mL，制造有3层结构的填充药液用塑料安瓶(内容积10mL)。该安瓶10具有图1所示的形状，管壁厚为内层50μm，中间层100μm，外层700μm。
<塑料安瓶的性能评价>
对实施例10的填充药液用塑料安瓶在106℃下实施高压蒸气灭菌40分钟，然后在60℃下保存2周，测定在安瓶内填充的维生素B2水溶液的维生素B2的含量。另外，维生素B2是光降解性的药剂。
测定结果是在保存2周后维生素B2的残存量为95重量％以上，表明其光降解性明显得到了充分的抑制。即，实施例10的安瓶防止光线透过的能力(光学阻隔性)良好。这认为是因为实施例10的安瓶带有混合了着色剂(有机颜料)制得的层。
而且，维生素B2水溶液对外层中所含颜料的溶解也明显得到了充分抑制。这认为是因为混合着色剂(有机颜料)制得的层内侧具有聚环烯烃层。
<填充药液的塑料安瓶的制造>
(实施例11)
使用带有5层吹模的吹塑、填充、封口机，由PE1(聚烯烃)制备内层、AD1(改性聚烯烃)制备中间层(内层侧)、NY1(聚酰胺；间二甲苯二胺-己二酸缩聚物)制备中间层(中间部)、AD1制备中间层(外层侧)和PP2(紫外线阻隔性塑料)制备外层，且在其内部填充400IU/mL的棕榈酸(パルチミン酸)维生素A溶液化液2mL，制造有5层结构的填充药液用塑料安瓶(内容积2mL)。该安瓶10具有图1所示的形状，管壁厚为内层50μm，中间层(内层侧和外层侧)各为10μm，中间层(中间部)为100μm，外层700μm。
<塑料安瓶的性能评价>
对实施例11的填充药液用塑料安瓶在106℃下实施高压蒸气灭菌40分钟，然后在60℃、60％RH下保存2周，测定在安瓶内填充的棕榈酸维生素A溶液化液的棕榈酸维生素A的含量。另外，棕榈酸维生素A是易氧化性和光降解性的药剂。
测定结果是在保存2周后棕榈酸维生素A的残存量为95重量％以上，表明其氧化劣化和光降解性得到了充分的抑制。即，实施例11的安瓶防止气体透过的能力(气体阻隔性，特别是氧阻隔性)和防止光线透过的能力(光线阻隔性)良好。这认为是因为实施例11的安瓶带有聚酰胺层和混合着色剂(有机颜料)制得的层。
而且，表明棕榈酸维生素A溶液化液对外层中所含颜料的溶解得到了充分抑制。这认为是因为混合着色剂(有机颜料)制得的层内侧具有聚酰胺层。
另外，实施例7～11中获得的塑料安瓶的层结构等汇总在表2中。
<表2>
上面：材质    中间：树脂的混合比例(重量比)    下面：层厚度
  内层                    中间层   外层   容积(mL)
  内层侧   中间部   外层侧
  实施例7   PE150μm   -   EVOH1100μm   -   PE1700μm   10
  实施例8   PE150μm   AD110μm   EVOH1100μm   AD110μm   PE1700μm   5
  实施例9   PE150μm   PE3100μm   -   EVOH1100μm   PE1600μm   10
  实施例10   PE150μm   -   COP1100μm   -   PE2700μm   10
  实施例11   PE150μm   AD110μm   NY1100μm   AD110μm   PP2500μm   2
<填充药液的塑料安瓶的制造>
(实施例12)
使用带有2层吹模的吹塑、填充、封口机，由COP2(聚环烯烃)制备内层、PE1(聚烯烃)制备外层，且在其内部填充生理盐水10mL，制造有2层结构的填充药液用塑料安瓶。该安瓶18具有图2所示的5连体形状，管壁厚为内层200μm，外层500μm。
(实施例13)
使用带有2层吹模的吹塑、填充、封口机，由COP2(聚环烯烃)制备内层、COP3(聚环烯烃)制备外层，且在其内部填充生理盐水10mL，制造有2层结构的填充药液用塑料安瓶。该安瓶18具有图2所示的5连体形状，管壁厚为内层200μm，外层500μm。
(实施例14)
使用带有2层吹模的吹塑、填充、封口机，由COCl(聚环烯烃)制备内层、PE1(聚烯烃)制备外层，且在其内部填充生理盐水10mL，制造有2层结构的填充药液用塑料安瓶。该安瓶18具有图2所示的5连体形状，管壁厚为内层200μm，外层500μm。
(实施例15)
使用带有2层吹模的吹塑、填充、封口机，由COC2(聚环烯烃)制备内层、PE1(聚环烯烃)制备外层，且在其内部填充生理盐水10mL，制造有2层结构的填充药液用塑料安瓶。该安瓶18具有图2所示的5连体形状，管壁厚为内层200μm，外层500μm。
(实施例16)
使用带有2层吹模的吹塑、填充、封口机，由COC3(聚环烯烃)制备内层、PE1(聚烯烃)制备外层，且在其内部填充生理盐水10mL，制造有2层结构的填充药液用塑料安瓶。该安瓶18具有图2所示的5连体形状，管壁厚为内层200μm，外层500μm。
(比较例1)
使用吹塑、填充、封口机，由COP3(聚环烯烃，Tg为136℃)制备，且在其内部填充生理盐水10mL，制造单层结构的塑料安瓶。该安瓶18具有图2所示的5连体形状，管壁厚为800μm。
(参考例1)
使用吹塑、填充、封口机，由COP2(聚环烯烃，Tg为70℃)制备，且在其内部填充生理盐水10mL，制造单层结构的塑料安瓶18。该安瓶18具有图2所示的5连体形状，管壁厚为800μm。
(参考例2)
使用吹塑、填充、封口机，由COC1(聚环烯烃，Tg为105℃)制备，且在其内部填充生理盐水10mL，制造单层结构的塑料安瓶18。该安瓶18具有图2所示的5连体形状，管壁厚为800μm。
<塑料安瓶的性能评价>
对于上述实施例12～16、比较例1和参考例1～2中得到的塑料安瓶目测确认有无液漏发生。其结果是形成内层的塑料是聚环烯烃、且玻璃化转变温度(Tg)在110℃或以下的实施例12～16的50支安瓶(10个5连体的安瓶)全部没有检测出有液漏。与此相对，比较例1的50支安瓶的8成即40个安瓶均检出有液漏。
另外，如参考例1和2所示，塑料安瓶在实际使用中也可以是由1种聚环状烯烃制得的单层体。这时，形成安瓶整体的聚环烯烃优选使用玻璃化转变温度在110℃或以下的聚环烯烃。聚环烯烃的玻璃化转变温度优选为60～105℃，更优选为60～80℃。
实施例12～16、比较例1和参考例1～2中获得的塑料安瓶的层结构等汇总在表3中。
<表3>
上面：材质(玻璃化转变温度℃)    下面：层厚度
  内层   外层   容积(mL)
  实施例12   COP2(70℃)200μm   PE1500μm   10
  实施例13   COP2(70℃)200μm   COP3(70℃)500μm   10
  实施例14   COC1(105℃)200μm   PE1500μm   10
  实施例15   COC2(70℃)200μm   PE1500μm   10
  实施例16   COC3(70℃)200μm   PE1500μm   10
  比较例1             COP3(136℃)800μm   10
  参考例1             COP2(70℃)800μm   10
  参考例2             COCl(105℃)800μm   10
如上所述，本发明提供的塑料安瓶可以用于无菌且稳定地保管、保存易氧化药剂、光降解性药剂、吸收吸附制剂等，进而可适用于该塑料安瓶的制造。

Claims (18)

1、一种用于填充药液的塑料安瓶，其特征在于该填充药液的塑料安瓶具有柔软性的容器主体部分、和封闭该容器主体部分开口部位的熔合部分、连在该熔合部分上的用于扭断熔合部分的把持部分，上述容器主体部分、熔合部分和把持部分是使用具有2层或2层以上的筒状型坯一体成形制得的，上述容器主体部分是用可分模夹住上述型坯来成形，在其内部填充药液，然后封闭开口部位制得的，并且上述型坯的至少1层是具有选自防止气体透过、防止水蒸汽透过、防止光线透过、防止药物透过和防止药物吸收、吸附功能的至少1种特性的功能性层。
2、如权利要求1记载的填充药液的塑料安瓶，其中上述型坯的最内层是由含有聚烯烃或聚环烯烃的树脂形成的。
3、如权利要求1记载的填充药液的塑料安瓶，其中除上述型坯的最内层以外的至少1层是通过混合选自着色剂、紫外线吸收剂和氧吸收剂的至少1种药剂来制得的层，且比该层更内侧的层是具有防止药物透过功能的层。
4、如权利要求1记载的填充药液的塑料安瓶，其中上述功能性层含有聚酰胺层。
5、如权利要求1记载的填充药液的塑料安瓶，其中上述功能性层含有多元醇层。
6、如权利要求1记载的填充药液的塑料安瓶，其中上述功能性层含有聚酯层。
7、如权利要求1记载的填充药液的塑料安瓶，其中上述功能性层含有聚环烯烃层。
8、如权利要求7记载的填充药液的塑料安瓶，其中至少最内层使用玻璃化转变温度在110℃或以下的聚环烯烃。
9、如权利要求8记载的填充药液的塑料安瓶，其中上述聚环烯烃的玻璃化转变温度为60～105℃。
10、如权利要求8记载的填充药液的塑料安瓶，其具有使用玻璃化转变温度在110℃或以下的聚环烯烃制得的最内层和包含玻璃化转变温度超过110℃的聚环烯烃的层。
11、如权利要求8记载的填充药液的塑料安瓶，其为由可以折断的薄壁部连接的多个安瓶的连接体。
12、如权利要求1记载的填充药液的塑料安瓶，其中上述功能性层为具有能防止水蒸汽透过和防止药物吸收、吸附功能的层，且其内容量为0.5～20mL。
13、一种填充药液用的塑料安瓶的制造方法，其特征在于包括下列步骤：在用容器主体部分成形用的下方可分模夹住带有2个或以上的层的筒状型坯，其中至少1个层是具有选自防止气体透过、防止水蒸汽透过、防止光线透过、防止药物透过和防止药物吸收、吸附的至少1种特性的功能性层，在筒状型坯的内部形成空洞来成形容器主体部分后，在该容器主体部分内填充药液，接着用上方可分模夹住该容器主体部分的开口部位，形成封闭该开口部位的熔合部分和连在该熔合部分上用于扭断熔合部分的把持部分。
14、如权利要求13记载的填充药液用的塑料安瓶的制造方法，其中作为上述型坯是使用最内层为含有聚烯烃或聚环烯烃的树脂来形成的制品。
15、如权利要求13记载的填充药液用的塑料安瓶的制造方法，其中作为上述型坯是使用除最内层之外至少有1层是混合了选自着色剂、紫外线吸收剂和氧吸收剂的至少1种药剂来制得的层，且比该层更内侧的层是具有防止药物透过功能的层。
16、如权利要求14记载的填充药液用的塑料安瓶的制造方法，其中作为上述型坯是使用其最内层是通过玻璃化转变温度在110℃或以下的聚环烯烃形成的制品。
17、如权利要求14记载的填充药液用的塑料安瓶的制造方法，其中作为上述型坯是使用其最内层是通过玻璃化转变温度为60～105℃的聚环烯烃形成的制品。
18、如权利要求14记载的填充药液用的塑料安瓶的制造方法，其中作为上述型坯是使用具有由玻璃化转变温度在110℃或以下的聚环烯烃形成的最内层和由玻璃化转变温度超过110℃的聚环烯烃形成的层的型坯。
CNB2004800106848A 2003-04-23 2004-04-19 填充了药液的塑料安瓿及其制造方法 Expired - Fee Related CN100515381C (zh)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
JP118901/2003 2003-04-23
JP2003118901 2003-04-23
JP364971/2003 2003-10-24

Publications (2)

Publication Number Publication Date
CN1777406A true CN1777406A (zh) 2006-05-24
CN100515381C CN100515381C (zh) 2009-07-22

Family

ID=36766599

Family Applications (1)

Application Number Title Priority Date Filing Date
CNB2004800106848A Expired - Fee Related CN100515381C (zh) 2003-04-23 2004-04-19 填充了药液的塑料安瓿及其制造方法

Country Status (1)

Country Link
CN (1) CN100515381C (zh)

Cited By (397)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN101969913A (zh) * 2008-03-14 2011-02-09 株式会社大塚制药工厂 塑料安瓿以及着色塑料容器
CN102229225A (zh) * 2010-08-27 2011-11-02 上海海昌医用塑胶厂 一种抗跌落coc塑料瓶的制作方法
CN102249174A (zh) * 2011-07-04 2011-11-23 楚天科技股份有限公司 一种塑料安瓿的成型装置
CN102274122A (zh) * 2011-05-20 2011-12-14 海南卫康制药(潜山)有限公司 适用于注射剂药品的包装瓶
CN102431946A (zh) * 2011-11-17 2012-05-02 楚天科技股份有限公司 一种塑料安瓿吹灌封一体机
CN102515071A (zh) * 2011-11-17 2012-06-27 楚天科技股份有限公司 塑料安瓿吹灌封一体机
CN102639095A (zh) * 2009-10-02 2012-08-15 株式会社细川洋行 存储容器
CN102836066A (zh) * 2008-03-14 2012-12-26 株式会社大塚制药工厂 塑料安瓿以及着色塑料容器
CN103315907A (zh) * 2012-03-19 2013-09-25 宝丽制药股份有限公司 填充有抗真菌药物组合物的树脂容器
CN103458849A (zh) * 2011-04-06 2013-12-18 株式会社大塚制药工厂 塑料安瓿
CN103619305A (zh) * 2011-06-30 2014-03-05 赛多利斯史泰迪生物技术有限责任公司 生物反应容器和用于生物反应容器的完整性检测方法
CN103796625A (zh) * 2011-07-14 2014-05-14 K·C·马塔 具有专用瓶头和密封件的便携式安瓿
CN103830274A (zh) * 2014-03-12 2014-06-04 蒲增军 鸡痘消除涂抹剂
CN104379069A (zh) * 2012-03-28 2015-02-25 伊西康内外科公司 包括贮存器的组织厚度补偿件
US9480746B2 (en) 2014-04-21 2016-11-01 Pola Pharma Inc. Resin container filled with antifungal pharmaceutical composition
CN107106409A (zh) * 2014-10-02 2017-08-29 泰尔茂株式会社 用于容纳蛋白质溶液制剂的医疗用容器
CN108785077A (zh) * 2018-05-31 2018-11-13 湖北科伦药业有限公司 一种利巴韦林安瓿瓶及其生产工艺
CN110139807A (zh) * 2016-12-29 2019-08-16 利乐拉瓦尔集团及财务有限公司 用于可灌装食品的包装和用于模制聚合物开口部分的方法
CN110505861A (zh) * 2017-04-13 2019-11-26 乐敦制药株式会社 挤压瓶
US10542974B2 (en) 2008-02-14 2020-01-28 Ethicon Llc Surgical instrument including a control system
US10568624B2 (en) 2016-12-21 2020-02-25 Ethicon Llc Surgical instruments with jaws that are pivotable about a fixed axis and include separate and distinct closure and firing systems
US10588633B2 (en) 2017-06-28 2020-03-17 Ethicon Llc Surgical instruments with open and closable jaws and axially movable firing member that is initially parked in close proximity to the jaws prior to firing
US10588630B2 (en) 2016-12-21 2020-03-17 Ethicon Llc Surgical tool assemblies with closure stroke reduction features
US10595882B2 (en) 2017-06-20 2020-03-24 Ethicon Llc Methods for closed loop control of motor velocity of a surgical stapling and cutting instrument
US10603039B2 (en) 2015-09-30 2020-03-31 Ethicon Llc Progressively releasable implantable adjunct for use with a surgical stapling instrument
US10603036B2 (en) 2016-12-21 2020-03-31 Ethicon Llc Articulatable surgical instrument with independent pivotable linkage distal of an articulation lock
USD879808S1 (en) 2017-06-20 2020-03-31 Ethicon Llc Display panel with graphical user interface
USD879809S1 (en) 2017-06-20 2020-03-31 Ethicon Llc Display panel with changeable graphical user interface
US10610224B2 (en) 2016-12-21 2020-04-07 Ethicon Llc Lockout arrangements for surgical end effectors and replaceable tool assemblies
US10617412B2 (en) 2015-03-06 2020-04-14 Ethicon Llc System for detecting the mis-insertion of a staple cartridge into a surgical stapler
US10617420B2 (en) 2011-05-27 2020-04-14 Ethicon Llc Surgical system comprising drive systems
US10617413B2 (en) 2016-04-01 2020-04-14 Ethicon Llc Closure system arrangements for surgical cutting and stapling devices with separate and distinct firing shafts
US10617416B2 (en) 2013-03-14 2020-04-14 Ethicon Llc Control systems for surgical instruments
US10617418B2 (en) 2015-08-17 2020-04-14 Ethicon Llc Implantable layers for a surgical instrument
US10617417B2 (en) 2014-11-06 2020-04-14 Ethicon Llc Staple cartridge comprising a releasable adjunct material
US10624861B2 (en) 2010-09-30 2020-04-21 Ethicon Llc Tissue thickness compensator configured to redistribute compressive forces
US10624633B2 (en) 2017-06-20 2020-04-21 Ethicon Llc Systems and methods for controlling motor velocity of a surgical stapling and cutting instrument
US10631859B2 (en) 2017-06-27 2020-04-28 Ethicon Llc Articulation systems for surgical instruments
US10639036B2 (en) 2008-02-14 2020-05-05 Ethicon Llc Robotically-controlled motorized surgical cutting and fastening instrument
US10646220B2 (en) 2017-06-20 2020-05-12 Ethicon Llc Systems and methods for controlling displacement member velocity for a surgical instrument
US10653435B2 (en) 2006-01-31 2020-05-19 Ethicon Llc Motor-driven surgical cutting and fastening instrument with tactile position feedback
US10660640B2 (en) 2008-02-14 2020-05-26 Ethicon Llc Motorized surgical cutting and fastening instrument
US10667809B2 (en) 2016-12-21 2020-06-02 Ethicon Llc Staple cartridge and staple cartridge channel comprising windows defined therein
US10667808B2 (en) 2012-03-28 2020-06-02 Ethicon Llc Staple cartridge comprising an absorbable adjunct
US10675028B2 (en) 2006-01-31 2020-06-09 Ethicon Llc Powered surgical instruments with firing system lockout arrangements
US10682138B2 (en) 2016-12-21 2020-06-16 Ethicon Llc Bilaterally asymmetric staple forming pocket pairs
US10682142B2 (en) 2008-02-14 2020-06-16 Ethicon Llc Surgical stapling apparatus including an articulation system
US10682134B2 (en) 2017-12-21 2020-06-16 Ethicon Llc Continuous use self-propelled stapling instrument
US10682141B2 (en) 2008-02-14 2020-06-16 Ethicon Llc Surgical device including a control system
US10687813B2 (en) 2017-12-15 2020-06-23 Ethicon Llc Adapters with firing stroke sensing arrangements for use in connection with electromechanical surgical instruments
US10687806B2 (en) 2015-03-06 2020-06-23 Ethicon Llc Adaptive tissue compression techniques to adjust closure rates for multiple tissue types
US10687812B2 (en) 2012-06-28 2020-06-23 Ethicon Llc Surgical instrument system including replaceable end effectors
US10687817B2 (en) 2004-07-28 2020-06-23 Ethicon Llc Stapling device comprising a firing member lockout
US10695062B2 (en) 2010-10-01 2020-06-30 Ethicon Llc Surgical instrument including a retractable firing member
US10695058B2 (en) 2014-12-18 2020-06-30 Ethicon Llc Surgical instrument systems comprising an articulatable end effector and means for adjusting the firing stroke of a firing member
US10695063B2 (en) 2012-02-13 2020-06-30 Ethicon Llc Surgical cutting and fastening instrument with apparatus for determining cartridge and firing motion status
US10702266B2 (en) 2013-04-16 2020-07-07 Ethicon Llc Surgical instrument system
US10702267B2 (en) 2007-03-15 2020-07-07 Ethicon Llc Surgical stapling instrument having a releasable buttress material
US10716565B2 (en) 2017-12-19 2020-07-21 Ethicon Llc Surgical instruments with dual articulation drivers
USD890784S1 (en) 2017-06-20 2020-07-21 Ethicon Llc Display panel with changeable graphical user interface
US10716614B2 (en) 2017-06-28 2020-07-21 Ethicon Llc Surgical shaft assemblies with slip ring assemblies with increased contact pressure
US10729509B2 (en) 2017-12-19 2020-08-04 Ethicon Llc Surgical instrument comprising closure and firing locking mechanism
US10736634B2 (en) 2011-05-27 2020-08-11 Ethicon Llc Robotically-driven surgical instrument including a drive system
US10736636B2 (en) 2014-12-10 2020-08-11 Ethicon Llc Articulatable surgical instrument system
US10736628B2 (en) 2008-09-23 2020-08-11 Ethicon Llc Motor-driven surgical cutting instrument
US10736633B2 (en) 2015-09-30 2020-08-11 Ethicon Llc Compressible adjunct with looping members
US10736630B2 (en) 2014-10-13 2020-08-11 Ethicon Llc Staple cartridge
US10743870B2 (en) 2008-02-14 2020-08-18 Ethicon Llc Surgical stapling apparatus with interlockable firing system
US10743872B2 (en) 2017-09-29 2020-08-18 Ethicon Llc System and methods for controlling a display of a surgical instrument
US10743874B2 (en) 2017-12-15 2020-08-18 Ethicon Llc Sealed adapters for use with electromechanical surgical instruments
US10743851B2 (en) 2008-02-14 2020-08-18 Ethicon Llc Interchangeable tools for surgical instruments
US10743875B2 (en) 2017-12-15 2020-08-18 Ethicon Llc Surgical end effectors with jaw stiffener arrangements configured to permit monitoring of firing member
US10743873B2 (en) 2014-12-18 2020-08-18 Ethicon Llc Drive arrangements for articulatable surgical instruments
US10743849B2 (en) 2006-01-31 2020-08-18 Ethicon Llc Stapling system including an articulation system
US10743877B2 (en) 2010-09-30 2020-08-18 Ethicon Llc Surgical stapler with floating anvil
US10751076B2 (en) 2009-12-24 2020-08-25 Ethicon Llc Motor-driven surgical cutting instrument with electric actuator directional control assembly
US10758230B2 (en) 2016-12-21 2020-09-01 Ethicon Llc Surgical instrument with primary and safety processors
US10758229B2 (en) 2016-12-21 2020-09-01 Ethicon Llc Surgical instrument comprising improved jaw control
US10765429B2 (en) 2017-09-29 2020-09-08 Ethicon Llc Systems and methods for providing alerts according to the operational state of a surgical instrument
US10765425B2 (en) 2008-09-23 2020-09-08 Ethicon Llc Robotically-controlled motorized surgical instrument with an end effector
US10765427B2 (en) 2017-06-28 2020-09-08 Ethicon Llc Method for articulating a surgical instrument
US10772625B2 (en) 2015-03-06 2020-09-15 Ethicon Llc Signal and power communication system positioned on a rotatable shaft
US10772629B2 (en) 2017-06-27 2020-09-15 Ethicon Llc Surgical anvil arrangements
US10780539B2 (en) 2011-05-27 2020-09-22 Ethicon Llc Stapling instrument for use with a robotic system
US10779825B2 (en) 2017-12-15 2020-09-22 Ethicon Llc Adapters with end effector position sensing and control arrangements for use in connection with electromechanical surgical instruments
US10779824B2 (en) 2017-06-28 2020-09-22 Ethicon Llc Surgical instrument comprising an articulation system lockable by a closure system
US10779821B2 (en) 2018-08-20 2020-09-22 Ethicon Llc Surgical stapler anvils with tissue stop features configured to avoid tissue pinch
US10779903B2 (en) 2017-10-31 2020-09-22 Ethicon Llc Positive shaft rotation lock activated by jaw closure
US10779826B2 (en) 2017-12-15 2020-09-22 Ethicon Llc Methods of operating surgical end effectors
US10779820B2 (en) 2017-06-20 2020-09-22 Ethicon Llc Systems and methods for controlling motor speed according to user input for a surgical instrument
US10779823B2 (en) 2016-12-21 2020-09-22 Ethicon Llc Firing member pin angle
US10806449B2 (en) 2005-11-09 2020-10-20 Ethicon Llc End effectors for surgical staplers
US10806448B2 (en) 2014-12-18 2020-10-20 Ethicon Llc Surgical instrument assembly comprising a flexible articulation system
US10813639B2 (en) 2017-06-20 2020-10-27 Ethicon Llc Closed loop feedback control of motor velocity of a surgical stapling and cutting instrument based on system conditions
US10828032B2 (en) 2013-08-23 2020-11-10 Ethicon Llc End effector detection systems for surgical instruments
US10828033B2 (en) 2017-12-15 2020-11-10 Ethicon Llc Handheld electromechanical surgical instruments with improved motor control arrangements for positioning components of an adapter coupled thereto
US10835251B2 (en) 2010-09-30 2020-11-17 Ethicon Llc Surgical instrument assembly including an end effector configurable in different positions
US10835330B2 (en) 2017-12-19 2020-11-17 Ethicon Llc Method for determining the position of a rotatable jaw of a surgical instrument attachment assembly
US10842490B2 (en) 2017-10-31 2020-11-24 Ethicon Llc Cartridge body design with force reduction based on firing completion
US10842489B2 (en) 2005-08-31 2020-11-24 Ethicon Llc Fastener cartridge assembly comprising a cam and driver arrangement
US10842492B2 (en) 2018-08-20 2020-11-24 Ethicon Llc Powered articulatable surgical instruments with clutching and locking arrangements for linking an articulation drive system to a firing drive system
US10856870B2 (en) 2018-08-20 2020-12-08 Ethicon Llc Switching arrangements for motor powered articulatable surgical instruments
US10856869B2 (en) 2017-06-27 2020-12-08 Ethicon Llc Surgical anvil arrangements
US10863986B2 (en) 2015-09-23 2020-12-15 Ethicon Llc Surgical stapler having downstream current-based motor control
US10863981B2 (en) 2014-03-26 2020-12-15 Ethicon Llc Interface systems for use with surgical instruments
US10869666B2 (en) 2017-12-15 2020-12-22 Ethicon Llc Adapters with control systems for controlling multiple motors of an electromechanical surgical instrument
USD906355S1 (en) 2017-06-28 2020-12-29 Ethicon Llc Display screen or portion thereof with a graphical user interface for a surgical instrument
US10881399B2 (en) 2017-06-20 2021-01-05 Ethicon Llc Techniques for adaptive control of motor velocity of a surgical stapling and cutting instrument
US10881396B2 (en) 2017-06-20 2021-01-05 Ethicon Llc Surgical instrument with variable duration trigger arrangement
USD907647S1 (en) 2017-09-29 2021-01-12 Ethicon Llc Display screen or portion thereof with animated graphical user interface
USD907648S1 (en) 2017-09-29 2021-01-12 Ethicon Llc Display screen or portion thereof with animated graphical user interface
US10888321B2 (en) 2017-06-20 2021-01-12 Ethicon Llc Systems and methods for controlling velocity of a displacement member of a surgical stapling and cutting instrument
US10893864B2 (en) 2016-12-21 2021-01-19 Ethicon Staple cartridges and arrangements of staples and staple cavities therein
US10893867B2 (en) 2013-03-14 2021-01-19 Ethicon Llc Drive train control arrangements for modular surgical instruments
US10898183B2 (en) 2017-06-29 2021-01-26 Ethicon Llc Robotic surgical instrument with closed loop feedback techniques for advancement of closure member during firing
US10903685B2 (en) 2017-06-28 2021-01-26 Ethicon Llc Surgical shaft assemblies with slip ring assemblies forming capacitive channels
US10905422B2 (en) 2016-12-21 2021-02-02 Ethicon Llc Surgical instrument for use with a robotic surgical system
US10905418B2 (en) 2014-10-16 2021-02-02 Ethicon Llc Staple cartridge comprising a tissue thickness compensator
US10905423B2 (en) 2014-09-05 2021-02-02 Ethicon Llc Smart cartridge wake up operation and data retention
US10912559B2 (en) 2018-08-20 2021-02-09 Ethicon Llc Reinforced deformable anvil tip for surgical stapler anvil
USD910847S1 (en) 2017-12-19 2021-02-16 Ethicon Llc Surgical instrument assembly
US10918386B2 (en) 2007-01-10 2021-02-16 Ethicon Llc Interlock and surgical instrument including same
US10918380B2 (en) 2006-01-31 2021-02-16 Ethicon Llc Surgical instrument system including a control system
US10932775B2 (en) 2012-06-28 2021-03-02 Ethicon Llc Firing system lockout arrangements for surgical instruments
US10932778B2 (en) 2008-10-10 2021-03-02 Ethicon Llc Powered surgical cutting and stapling apparatus with manually retractable firing system
US10932772B2 (en) 2017-06-29 2021-03-02 Ethicon Llc Methods for closed loop velocity control for robotic surgical instrument
US10945731B2 (en) 2010-09-30 2021-03-16 Ethicon Llc Tissue thickness compensator comprising controlled release and expansion
US10945728B2 (en) 2014-12-18 2021-03-16 Ethicon Llc Locking arrangements for detachable shaft assemblies with articulatable surgical end effectors
USD914878S1 (en) 2018-08-20 2021-03-30 Ethicon Llc Surgical instrument anvil
US10959725B2 (en) 2012-06-15 2021-03-30 Ethicon Llc Articulatable surgical instrument comprising a firing drive
US10966627B2 (en) 2015-03-06 2021-04-06 Ethicon Llc Time dependent evaluation of sensor data to determine stability, creep, and viscoelastic elements of measures
US10966718B2 (en) 2017-12-15 2021-04-06 Ethicon Llc Dynamic clamping assemblies with improved wear characteristics for use in connection with electromechanical surgical instruments
US10980537B2 (en) 2017-06-20 2021-04-20 Ethicon Llc Closed loop feedback control of motor velocity of a surgical stapling and cutting instrument based on measured time over a specified number of shaft rotations
US10980539B2 (en) 2015-09-30 2021-04-20 Ethicon Llc Implantable adjunct comprising bonded layers
USD917500S1 (en) 2017-09-29 2021-04-27 Ethicon Llc Display screen or portion thereof with graphical user interface
US10987102B2 (en) 2010-09-30 2021-04-27 Ethicon Llc Tissue thickness compensator comprising a plurality of layers
US10993717B2 (en) 2006-01-31 2021-05-04 Ethicon Llc Surgical stapling system comprising a control system
US10993716B2 (en) 2017-06-27 2021-05-04 Ethicon Llc Surgical anvil arrangements
US11000275B2 (en) 2006-01-31 2021-05-11 Ethicon Llc Surgical instrument
US11006951B2 (en) 2007-01-10 2021-05-18 Ethicon Llc Surgical instrument with wireless communication between control unit and sensor transponders
US11007022B2 (en) 2017-06-29 2021-05-18 Ethicon Llc Closed loop velocity control techniques based on sensed tissue parameters for robotic surgical instrument
US11006955B2 (en) 2017-12-15 2021-05-18 Ethicon Llc End effectors with positive jaw opening features for use with adapters for electromechanical surgical instruments
US11013511B2 (en) 2007-06-22 2021-05-25 Ethicon Llc Surgical stapling instrument with an articulatable end effector
US11020112B2 (en) 2017-12-19 2021-06-01 Ethicon Llc Surgical tools configured for interchangeable use with different controller interfaces
US11020115B2 (en) 2014-02-12 2021-06-01 Cilag Gmbh International Deliverable surgical instrument
US11026678B2 (en) 2015-09-23 2021-06-08 Cilag Gmbh International Surgical stapler having motor control based on an electrical parameter related to a motor current
US11026684B2 (en) 2016-04-15 2021-06-08 Ethicon Llc Surgical instrument with multiple program responses during a firing motion
US11033267B2 (en) 2017-12-15 2021-06-15 Ethicon Llc Systems and methods of controlling a clamping member firing rate of a surgical instrument
US11039834B2 (en) 2018-08-20 2021-06-22 Cilag Gmbh International Surgical stapler anvils with staple directing protrusions and tissue stability features
US11039836B2 (en) 2007-01-11 2021-06-22 Cilag Gmbh International Staple cartridge for use with a surgical stapling instrument
US11045270B2 (en) 2017-12-19 2021-06-29 Cilag Gmbh International Robotic attachment comprising exterior drive actuator
US11045192B2 (en) 2018-08-20 2021-06-29 Cilag Gmbh International Fabricating techniques for surgical stapler anvils
US11051807B2 (en) 2019-06-28 2021-07-06 Cilag Gmbh International Packaging assembly including a particulate trap
US11051810B2 (en) 2016-04-15 2021-07-06 Cilag Gmbh International Modular surgical instrument with configurable operating mode
US11051813B2 (en) 2006-01-31 2021-07-06 Cilag Gmbh International Powered surgical instruments with firing system lockout arrangements
US11058422B2 (en) 2015-12-30 2021-07-13 Cilag Gmbh International Mechanisms for compensating for battery pack failure in powered surgical instruments
US11071543B2 (en) 2017-12-15 2021-07-27 Cilag Gmbh International Surgical end effectors with clamping assemblies configured to increase jaw aperture ranges
US11071554B2 (en) 2017-06-20 2021-07-27 Cilag Gmbh International Closed loop feedback control of motor velocity of a surgical stapling and cutting instrument based on magnitude of velocity error measurements
US11071545B2 (en) 2014-09-05 2021-07-27 Cilag Gmbh International Smart cartridge wake up operation and data retention
US11076929B2 (en) 2015-09-25 2021-08-03 Cilag Gmbh International Implantable adjunct systems for determining adjunct skew
US11076853B2 (en) 2017-12-21 2021-08-03 Cilag Gmbh International Systems and methods of displaying a knife position during transection for a surgical instrument
US11083454B2 (en) 2015-12-30 2021-08-10 Cilag Gmbh International Mechanisms for compensating for drivetrain failure in powered surgical instruments
US11083452B2 (en) 2010-09-30 2021-08-10 Cilag Gmbh International Staple cartridge including a tissue thickness compensator
US11083453B2 (en) 2014-12-18 2021-08-10 Cilag Gmbh International Surgical stapling system including a flexible firing actuator and lateral buckling supports
US11083458B2 (en) 2018-08-20 2021-08-10 Cilag Gmbh International Powered surgical instruments with clutching arrangements to convert linear drive motions to rotary drive motions
US11090046B2 (en) 2017-06-20 2021-08-17 Cilag Gmbh International Systems and methods for controlling displacement member motion of a surgical stapling and cutting instrument
US11090075B2 (en) 2017-10-30 2021-08-17 Cilag Gmbh International Articulation features for surgical end effector
US11090045B2 (en) 2005-08-31 2021-08-17 Cilag Gmbh International Staple cartridges for forming staples having differing formed staple heights
CN113302133A (zh) * 2018-12-07 2021-08-24 藤森工业株式会社 滴眼剂容器
US11096689B2 (en) 2016-12-21 2021-08-24 Cilag Gmbh International Shaft assembly comprising a lockout
US11109859B2 (en) 2015-03-06 2021-09-07 Cilag Gmbh International Surgical instrument comprising a lockable battery housing
US11133106B2 (en) 2013-08-23 2021-09-28 Cilag Gmbh International Surgical instrument assembly comprising a retraction assembly
US11129615B2 (en) 2009-02-05 2021-09-28 Cilag Gmbh International Surgical stapling system
US11129680B2 (en) 2017-12-21 2021-09-28 Cilag Gmbh International Surgical instrument comprising a projector
US11129613B2 (en) 2015-12-30 2021-09-28 Cilag Gmbh International Surgical instruments with separable motors and motor control circuits
US11134944B2 (en) 2017-10-30 2021-10-05 Cilag Gmbh International Surgical stapler knife motion controls
US11134938B2 (en) 2007-06-04 2021-10-05 Cilag Gmbh International Robotically-controlled shaft based rotary drive systems for surgical instruments
US11134942B2 (en) 2016-12-21 2021-10-05 Cilag Gmbh International Surgical stapling instruments and staple-forming anvils
US11134947B2 (en) 2005-08-31 2021-10-05 Cilag Gmbh International Fastener cartridge assembly comprising a camming sled with variable cam arrangements
US11135352B2 (en) 2004-07-28 2021-10-05 Cilag Gmbh International End effector including a gradually releasable medical adjunct
US11141153B2 (en) 2014-10-29 2021-10-12 Cilag Gmbh International Staple cartridges comprising driver arrangements
US11147551B2 (en) 2019-03-25 2021-10-19 Cilag Gmbh International Firing drive arrangements for surgical systems
US11147554B2 (en) 2016-04-18 2021-10-19 Cilag Gmbh International Surgical instrument system comprising a magnetic lockout
US11147553B2 (en) 2019-03-25 2021-10-19 Cilag Gmbh International Firing drive arrangements for surgical systems
US11154296B2 (en) 2010-09-30 2021-10-26 Cilag Gmbh International Anvil layer attached to a proximal end of an end effector
US11154301B2 (en) 2015-02-27 2021-10-26 Cilag Gmbh International Modular stapling assembly
US11154297B2 (en) 2008-02-15 2021-10-26 Cilag Gmbh International Layer arrangements for surgical staple cartridges
US11172929B2 (en) 2019-03-25 2021-11-16 Cilag Gmbh International Articulation drive arrangements for surgical systems
US11179150B2 (en) 2016-04-15 2021-11-23 Cilag Gmbh International Systems and methods for controlling a surgical stapling and cutting instrument
US11191545B2 (en) 2016-04-15 2021-12-07 Cilag Gmbh International Staple formation detection mechanisms
US11197671B2 (en) 2012-06-28 2021-12-14 Cilag Gmbh International Stapling assembly comprising a lockout
US11197670B2 (en) 2017-12-15 2021-12-14 Cilag Gmbh International Surgical end effectors with pivotal jaws configured to touch at their respective distal ends when fully closed
US11202633B2 (en) 2014-09-26 2021-12-21 Cilag Gmbh International Surgical stapling buttresses and adjunct materials
US11207064B2 (en) 2011-05-27 2021-12-28 Cilag Gmbh International Automated end effector component reloading system for use with a robotic system
US11207065B2 (en) 2018-08-20 2021-12-28 Cilag Gmbh International Method for fabricating surgical stapler anvils
US11213293B2 (en) 2016-02-09 2022-01-04 Cilag Gmbh International Articulatable surgical instruments with single articulation link arrangements
US11219455B2 (en) 2019-06-28 2022-01-11 Cilag Gmbh International Surgical instrument including a lockout key
US11224428B2 (en) 2016-12-21 2022-01-18 Cilag Gmbh International Surgical stapling systems
US11224497B2 (en) 2019-06-28 2022-01-18 Cilag Gmbh International Surgical systems with multiple RFID tags
US11224427B2 (en) 2006-01-31 2022-01-18 Cilag Gmbh International Surgical stapling system including a console and retraction assembly
US11224423B2 (en) 2015-03-06 2022-01-18 Cilag Gmbh International Smart sensors with local signal processing
US11224426B2 (en) 2016-02-12 2022-01-18 Cilag Gmbh International Mechanisms for compensating for drivetrain failure in powered surgical instruments
US11229437B2 (en) 2019-06-28 2022-01-25 Cilag Gmbh International Method for authenticating the compatibility of a staple cartridge with a surgical instrument
US11234698B2 (en) 2019-12-19 2022-02-01 Cilag Gmbh International Stapling system comprising a clamp lockout and a firing lockout
US11241230B2 (en) 2012-06-28 2022-02-08 Cilag Gmbh International Clip applier tool for use with a robotic surgical system
US11246618B2 (en) 2013-03-01 2022-02-15 Cilag Gmbh International Surgical instrument soft stop
US11246678B2 (en) 2019-06-28 2022-02-15 Cilag Gmbh International Surgical stapling system having a frangible RFID tag
US11246590B2 (en) 2005-08-31 2022-02-15 Cilag Gmbh International Staple cartridge including staple drivers having different unfired heights
US11246592B2 (en) 2017-06-28 2022-02-15 Cilag Gmbh International Surgical instrument comprising an articulation system lockable to a frame
US11253254B2 (en) 2019-04-30 2022-02-22 Cilag Gmbh International Shaft rotation actuator on a surgical instrument
US11253256B2 (en) 2018-08-20 2022-02-22 Cilag Gmbh International Articulatable motor powered surgical instruments with dedicated articulation motor arrangements
US11259803B2 (en) 2019-06-28 2022-03-01 Cilag Gmbh International Surgical stapling system having an information encryption protocol
US11259799B2 (en) 2014-03-26 2022-03-01 Cilag Gmbh International Interface systems for use with surgical instruments
US11259805B2 (en) 2017-06-28 2022-03-01 Cilag Gmbh International Surgical instrument comprising firing member supports
US11266409B2 (en) 2014-04-16 2022-03-08 Cilag Gmbh International Fastener cartridge comprising a sled including longitudinally-staggered ramps
US11266405B2 (en) 2017-06-27 2022-03-08 Cilag Gmbh International Surgical anvil manufacturing methods
US11272938B2 (en) 2006-06-27 2022-03-15 Cilag Gmbh International Surgical instrument including dedicated firing and retraction assemblies
US11278279B2 (en) 2006-01-31 2022-03-22 Cilag Gmbh International Surgical instrument assembly
US11284898B2 (en) 2014-09-18 2022-03-29 Cilag Gmbh International Surgical instrument including a deployable knife
US11291447B2 (en) 2019-12-19 2022-04-05 Cilag Gmbh International Stapling instrument comprising independent jaw closing and staple firing systems
US11291451B2 (en) 2019-06-28 2022-04-05 Cilag Gmbh International Surgical instrument with battery compatibility verification functionality
US11291449B2 (en) 2009-12-24 2022-04-05 Cilag Gmbh International Surgical cutting instrument that analyzes tissue thickness
US11291441B2 (en) 2007-01-10 2022-04-05 Cilag Gmbh International Surgical instrument with wireless communication between control unit and remote sensor
US11291440B2 (en) 2018-08-20 2022-04-05 Cilag Gmbh International Method for operating a powered articulatable surgical instrument
US11298127B2 (en) 2019-06-28 2022-04-12 Cilag GmbH Interational Surgical stapling system having a lockout mechanism for an incompatible cartridge
US11298125B2 (en) 2010-09-30 2022-04-12 Cilag Gmbh International Tissue stapler having a thickness compensator
US11298132B2 (en) 2019-06-28 2022-04-12 Cilag GmbH Inlernational Staple cartridge including a honeycomb extension
US11304696B2 (en) 2019-12-19 2022-04-19 Cilag Gmbh International Surgical instrument comprising a powered articulation system
US11304695B2 (en) 2017-08-03 2022-04-19 Cilag Gmbh International Surgical system shaft interconnection
US11311292B2 (en) 2016-04-15 2022-04-26 Cilag Gmbh International Surgical instrument with detection sensors
US11311290B2 (en) 2017-12-21 2022-04-26 Cilag Gmbh International Surgical instrument comprising an end effector dampener
US11311294B2 (en) 2014-09-05 2022-04-26 Cilag Gmbh International Powered medical device including measurement of closure state of jaws
US11317913B2 (en) 2016-12-21 2022-05-03 Cilag Gmbh International Lockout arrangements for surgical end effectors and replaceable tool assemblies
US11317917B2 (en) 2016-04-18 2022-05-03 Cilag Gmbh International Surgical stapling system comprising a lockable firing assembly
US11324503B2 (en) 2017-06-27 2022-05-10 Cilag Gmbh International Surgical firing member arrangements
US11324501B2 (en) 2018-08-20 2022-05-10 Cilag Gmbh International Surgical stapling devices with improved closure members
US11344303B2 (en) 2016-02-12 2022-05-31 Cilag Gmbh International Mechanisms for compensating for drivetrain failure in powered surgical instruments
US11350932B2 (en) 2016-04-15 2022-06-07 Cilag Gmbh International Surgical instrument with improved stop/start control during a firing motion
US11350928B2 (en) 2016-04-18 2022-06-07 Cilag Gmbh International Surgical instrument comprising a tissue thickness lockout and speed control system
US11376098B2 (en) 2019-06-28 2022-07-05 Cilag Gmbh International Surgical instrument system comprising an RFID system
US11382627B2 (en) 2014-04-16 2022-07-12 Cilag Gmbh International Surgical stapling assembly comprising a firing member including a lateral extension
US11382638B2 (en) 2017-06-20 2022-07-12 Cilag Gmbh International Closed loop feedback control of motor velocity of a surgical stapling and cutting instrument based on measured time over a specified displacement distance
US11399837B2 (en) 2019-06-28 2022-08-02 Cilag Gmbh International Mechanisms for motor control adjustments of a motorized surgical instrument
US11399829B2 (en) 2017-09-29 2022-08-02 Cilag Gmbh International Systems and methods of initiating a power shutdown mode for a surgical instrument
US11406380B2 (en) 2008-09-23 2022-08-09 Cilag Gmbh International Motorized surgical instrument
US11419606B2 (en) 2016-12-21 2022-08-23 Cilag Gmbh International Shaft assembly comprising a clutch configured to adapt the output of a rotary firing member to two different systems
US11426251B2 (en) 2019-04-30 2022-08-30 Cilag Gmbh International Articulation directional lights on a surgical instrument
US11426167B2 (en) 2019-06-28 2022-08-30 Cilag Gmbh International Mechanisms for proper anvil attachment surgical stapling head assembly
US11432816B2 (en) 2019-04-30 2022-09-06 Cilag Gmbh International Articulation pin for a surgical instrument
US11439470B2 (en) 2011-05-27 2022-09-13 Cilag Gmbh International Robotically-controlled surgical instrument with selectively articulatable end effector
US11446029B2 (en) 2019-12-19 2022-09-20 Cilag Gmbh International Staple cartridge comprising projections extending from a curved deck surface
US11452526B2 (en) 2020-10-29 2022-09-27 Cilag Gmbh International Surgical instrument comprising a staged voltage regulation start-up system
US11452528B2 (en) 2019-04-30 2022-09-27 Cilag Gmbh International Articulation actuators for a surgical instrument
US11457918B2 (en) 2014-10-29 2022-10-04 Cilag Gmbh International Cartridge assemblies for surgical staplers
US11464513B2 (en) 2012-06-28 2022-10-11 Cilag Gmbh International Surgical instrument system including replaceable end effectors
US11464512B2 (en) 2019-12-19 2022-10-11 Cilag Gmbh International Staple cartridge comprising a curved deck surface
US11464601B2 (en) 2019-06-28 2022-10-11 Cilag Gmbh International Surgical instrument comprising an RFID system for tracking a movable component
USD966512S1 (en) 2020-06-02 2022-10-11 Cilag Gmbh International Staple cartridge
USD967421S1 (en) 2020-06-02 2022-10-18 Cilag Gmbh International Staple cartridge
US11471157B2 (en) 2019-04-30 2022-10-18 Cilag Gmbh International Articulation control mapping for a surgical instrument
US11471155B2 (en) 2017-08-03 2022-10-18 Cilag Gmbh International Surgical system bailout
US11478241B2 (en) 2019-06-28 2022-10-25 Cilag Gmbh International Staple cartridge including projections
US11478247B2 (en) 2010-07-30 2022-10-25 Cilag Gmbh International Tissue acquisition arrangements and methods for surgical stapling devices
US11484311B2 (en) 2005-08-31 2022-11-01 Cilag Gmbh International Staple cartridge comprising a staple driver arrangement
US11484312B2 (en) 2005-08-31 2022-11-01 Cilag Gmbh International Staple cartridge comprising a staple driver arrangement
US11497492B2 (en) 2019-06-28 2022-11-15 Cilag Gmbh International Surgical instrument including an articulation lock
US11497488B2 (en) 2014-03-26 2022-11-15 Cilag Gmbh International Systems and methods for controlling a segmented circuit
US11504122B2 (en) 2019-12-19 2022-11-22 Cilag Gmbh International Surgical instrument comprising a nested firing member
US11504116B2 (en) 2011-04-29 2022-11-22 Cilag Gmbh International Layer of material for a surgical end effector
US11517325B2 (en) 2017-06-20 2022-12-06 Cilag Gmbh International Closed loop feedback control of motor velocity of a surgical stapling and cutting instrument based on measured displacement distance traveled over a specified time interval
US11517315B2 (en) 2014-04-16 2022-12-06 Cilag Gmbh International Fastener cartridges including extensions having different configurations
US11517390B2 (en) 2020-10-29 2022-12-06 Cilag Gmbh International Surgical instrument comprising a limited travel switch
US11523821B2 (en) 2014-09-26 2022-12-13 Cilag Gmbh International Method for creating a flexible staple line
US11523823B2 (en) 2016-02-09 2022-12-13 Cilag Gmbh International Surgical instruments with non-symmetrical articulation arrangements
US11523822B2 (en) 2019-06-28 2022-12-13 Cilag Gmbh International Battery pack including a circuit interrupter
US11529137B2 (en) 2019-12-19 2022-12-20 Cilag Gmbh International Staple cartridge comprising driver retention members
US11529138B2 (en) 2013-03-01 2022-12-20 Cilag Gmbh International Powered surgical instrument including a rotary drive screw
US11529139B2 (en) 2019-12-19 2022-12-20 Cilag Gmbh International Motor driven surgical instrument
US11534259B2 (en) 2020-10-29 2022-12-27 Cilag Gmbh International Surgical instrument comprising an articulation indicator
USD974560S1 (en) 2020-06-02 2023-01-03 Cilag Gmbh International Staple cartridge
USD975278S1 (en) 2020-06-02 2023-01-10 Cilag Gmbh International Staple cartridge
US11553971B2 (en) 2019-06-28 2023-01-17 Cilag Gmbh International Surgical RFID assemblies for display and communication
USD975850S1 (en) 2020-06-02 2023-01-17 Cilag Gmbh International Staple cartridge
USD975851S1 (en) 2020-06-02 2023-01-17 Cilag Gmbh International Staple cartridge
US11559304B2 (en) 2019-12-19 2023-01-24 Cilag Gmbh International Surgical instrument comprising a rapid closure mechanism
USD976401S1 (en) 2020-06-02 2023-01-24 Cilag Gmbh International Staple cartridge
US11564686B2 (en) 2017-06-28 2023-01-31 Cilag Gmbh International Surgical shaft assemblies with flexible interfaces
US11564682B2 (en) 2007-06-04 2023-01-31 Cilag Gmbh International Surgical stapler device
US11571215B2 (en) 2010-09-30 2023-02-07 Cilag Gmbh International Layer of material for a surgical end effector
US11571231B2 (en) 2006-09-29 2023-02-07 Cilag Gmbh International Staple cartridge having a driver for driving multiple staples
US11576672B2 (en) 2019-12-19 2023-02-14 Cilag Gmbh International Surgical instrument comprising a closure system including a closure member and an opening member driven by a drive screw
USD980425S1 (en) 2020-10-29 2023-03-07 Cilag Gmbh International Surgical instrument assembly
US11607219B2 (en) 2019-12-19 2023-03-21 Cilag Gmbh International Staple cartridge comprising a detachable tissue cutting knife
US11607239B2 (en) 2016-04-15 2023-03-21 Cilag Gmbh International Systems and methods for controlling a surgical stapling and cutting instrument
US11617577B2 (en) 2020-10-29 2023-04-04 Cilag Gmbh International Surgical instrument comprising a sensor configured to sense whether an articulation drive of the surgical instrument is actuatable
US11622763B2 (en) 2013-04-16 2023-04-11 Cilag Gmbh International Stapling assembly comprising a shiftable drive
US11622766B2 (en) 2012-06-28 2023-04-11 Cilag Gmbh International Empty clip cartridge lockout
US11627960B2 (en) 2020-12-02 2023-04-18 Cilag Gmbh International Powered surgical instruments with smart reload with separately attachable exteriorly mounted wiring connections
US11627959B2 (en) 2019-06-28 2023-04-18 Cilag Gmbh International Surgical instruments including manual and powered system lockouts
US11638587B2 (en) 2019-06-28 2023-05-02 Cilag Gmbh International RFID identification systems for surgical instruments
US11638582B2 (en) 2020-07-28 2023-05-02 Cilag Gmbh International Surgical instruments with torsion spine drive arrangements
US11642125B2 (en) 2016-04-15 2023-05-09 Cilag Gmbh International Robotic surgical system including a user interface and a control circuit
US11648005B2 (en) 2008-09-23 2023-05-16 Cilag Gmbh International Robotically-controlled motorized surgical instrument with an end effector
US11648009B2 (en) 2019-04-30 2023-05-16 Cilag Gmbh International Rotatable jaw tip for a surgical instrument
US11653915B2 (en) 2020-12-02 2023-05-23 Cilag Gmbh International Surgical instruments with sled location detection and adjustment features
US11653920B2 (en) 2020-12-02 2023-05-23 Cilag Gmbh International Powered surgical instruments with communication interfaces through sterile barrier
US11653914B2 (en) 2017-06-20 2023-05-23 Cilag Gmbh International Systems and methods for controlling motor velocity of a surgical stapling and cutting instrument according to articulation angle of end effector
US11660163B2 (en) 2019-06-28 2023-05-30 Cilag Gmbh International Surgical system with RFID tags for updating motor assembly parameters
US11678877B2 (en) 2014-12-18 2023-06-20 Cilag Gmbh International Surgical instrument including a flexible support configured to support a flexible firing member
US11678882B2 (en) 2020-12-02 2023-06-20 Cilag Gmbh International Surgical instruments with interactive features to remedy incidental sled movements
US11684434B2 (en) 2019-06-28 2023-06-27 Cilag Gmbh International Surgical RFID assemblies for instrument operational setting control
US11696761B2 (en) 2019-03-25 2023-07-11 Cilag Gmbh International Firing drive arrangements for surgical systems
US11696757B2 (en) 2021-02-26 2023-07-11 Cilag Gmbh International Monitoring of internal systems to detect and track cartridge motion status
US11701113B2 (en) 2021-02-26 2023-07-18 Cilag Gmbh International Stapling instrument comprising a separate power antenna and a data transfer antenna
US11701111B2 (en) 2019-12-19 2023-07-18 Cilag Gmbh International Method for operating a surgical stapling instrument
US11717291B2 (en) 2021-03-22 2023-08-08 Cilag Gmbh International Staple cartridge comprising staples configured to apply different tissue compression
US11717294B2 (en) 2014-04-16 2023-08-08 Cilag Gmbh International End effector arrangements comprising indicators
US11717289B2 (en) 2020-10-29 2023-08-08 Cilag Gmbh International Surgical instrument comprising an indicator which indicates that an articulation drive is actuatable
US11723657B2 (en) 2021-02-26 2023-08-15 Cilag Gmbh International Adjustable communication based on available bandwidth and power capacity
US11723662B2 (en) 2021-05-28 2023-08-15 Cilag Gmbh International Stapling instrument comprising an articulation control display
US11723658B2 (en) 2021-03-22 2023-08-15 Cilag Gmbh International Staple cartridge comprising a firing lockout
US11730473B2 (en) 2021-02-26 2023-08-22 Cilag Gmbh International Monitoring of manufacturing life-cycle
US11737751B2 (en) 2020-12-02 2023-08-29 Cilag Gmbh International Devices and methods of managing energy dissipated within sterile barriers of surgical instrument housings
US11737749B2 (en) 2021-03-22 2023-08-29 Cilag Gmbh International Surgical stapling instrument comprising a retraction system
US11749877B2 (en) 2021-02-26 2023-09-05 Cilag Gmbh International Stapling instrument comprising a signal antenna
US11744583B2 (en) 2021-02-26 2023-09-05 Cilag Gmbh International Distal communication array to tune frequency of RF systems
US11744603B2 (en) 2021-03-24 2023-09-05 Cilag Gmbh International Multi-axis pivot joints for surgical instruments and methods for manufacturing same
US11744581B2 (en) 2020-12-02 2023-09-05 Cilag Gmbh International Powered surgical instruments with multi-phase tissue treatment
US11751869B2 (en) 2021-02-26 2023-09-12 Cilag Gmbh International Monitoring of multiple sensors over time to detect moving characteristics of tissue
US11759202B2 (en) 2021-03-22 2023-09-19 Cilag Gmbh International Staple cartridge comprising an implantable layer
US11766259B2 (en) 2016-12-21 2023-09-26 Cilag Gmbh International Method of deforming staples from two different types of staple cartridges with the same surgical stapling instrument
US11766260B2 (en) 2016-12-21 2023-09-26 Cilag Gmbh International Methods of stapling tissue
US11771419B2 (en) 2019-06-28 2023-10-03 Cilag Gmbh International Packaging for a replaceable component of a surgical stapling system
US11779420B2 (en) 2012-06-28 2023-10-10 Cilag Gmbh International Robotic surgical attachments having manually-actuated retraction assemblies
US11779330B2 (en) 2020-10-29 2023-10-10 Cilag Gmbh International Surgical instrument comprising a jaw alignment system
US11786239B2 (en) 2021-03-24 2023-10-17 Cilag Gmbh International Surgical instrument articulation joint arrangements comprising multiple moving linkage features
US11786243B2 (en) 2021-03-24 2023-10-17 Cilag Gmbh International Firing members having flexible portions for adapting to a load during a surgical firing stroke
US11793516B2 (en) 2021-03-24 2023-10-24 Cilag Gmbh International Surgical staple cartridge comprising longitudinal support beam
US11793514B2 (en) 2021-02-26 2023-10-24 Cilag Gmbh International Staple cartridge comprising sensor array which may be embedded in cartridge body
US11793522B2 (en) 2015-09-30 2023-10-24 Cilag Gmbh International Staple cartridge assembly including a compressible adjunct
US11793518B2 (en) 2006-01-31 2023-10-24 Cilag Gmbh International Powered surgical instruments with firing system lockout arrangements
US11806011B2 (en) 2021-03-22 2023-11-07 Cilag Gmbh International Stapling instrument comprising tissue compression systems
US11812964B2 (en) 2021-02-26 2023-11-14 Cilag Gmbh International Staple cartridge comprising a power management circuit
US11826012B2 (en) 2021-03-22 2023-11-28 Cilag Gmbh International Stapling instrument comprising a pulsed motor-driven firing rack
US11826042B2 (en) 2021-03-22 2023-11-28 Cilag Gmbh International Surgical instrument comprising a firing drive including a selectable leverage mechanism
US11826048B2 (en) 2017-06-28 2023-11-28 Cilag Gmbh International Surgical instrument comprising selectively actuatable rotatable couplers
US11826132B2 (en) 2015-03-06 2023-11-28 Cilag Gmbh International Time dependent evaluation of sensor data to determine stability, creep, and viscoelastic elements of measures
US11832816B2 (en) 2021-03-24 2023-12-05 Cilag Gmbh International Surgical stapling assembly comprising nonplanar staples and planar staples
US11839352B2 (en) 2007-01-11 2023-12-12 Cilag Gmbh International Surgical stapling device with an end effector
US11844518B2 (en) 2020-10-29 2023-12-19 Cilag Gmbh International Method for operating a surgical instrument
US11844520B2 (en) 2019-12-19 2023-12-19 Cilag Gmbh International Staple cartridge comprising driver retention members
US11849944B2 (en) 2021-03-24 2023-12-26 Cilag Gmbh International Drivers for fastener cartridge assemblies having rotary drive screws
US11849943B2 (en) 2020-12-02 2023-12-26 Cilag Gmbh International Surgical instrument with cartridge release mechanisms
US11849952B2 (en) 2010-09-30 2023-12-26 Cilag Gmbh International Staple cartridge comprising staples positioned within a compressible portion thereof
US11849945B2 (en) 2021-03-24 2023-12-26 Cilag Gmbh International Rotary-driven surgical stapling assembly comprising eccentrically driven firing member
US11849941B2 (en) 2007-06-29 2023-12-26 Cilag Gmbh International Staple cartridge having staple cavities extending at a transverse angle relative to a longitudinal cartridge axis
US11857183B2 (en) 2021-03-24 2024-01-02 Cilag Gmbh International Stapling assembly components having metal substrates and plastic bodies
US11877745B2 (en) 2021-10-18 2024-01-23 Cilag Gmbh International Surgical stapling assembly having longitudinally-repeating staple leg clusters
US11883026B2 (en) 2014-04-16 2024-01-30 Cilag Gmbh International Fastener cartridge assemblies and staple retainer cover arrangements
USD1013170S1 (en) 2020-10-29 2024-01-30 Cilag Gmbh International Surgical instrument assembly
US11883020B2 (en) 2006-01-31 2024-01-30 Cilag Gmbh International Surgical instrument having a feedback system
US11890010B2 (en) 2020-12-02 2024-02-06 Cllag GmbH International Dual-sided reinforced reload for surgical instruments
US11890012B2 (en) 2004-07-28 2024-02-06 Cilag Gmbh International Staple cartridge comprising cartridge body and attached support
US11896218B2 (en) 2021-03-24 2024-02-13 Cilag Gmbh International Method of using a powered stapling device
US11896219B2 (en) 2021-03-24 2024-02-13 Cilag Gmbh International Mating features between drivers and underside of a cartridge deck
US11896217B2 (en) 2020-10-29 2024-02-13 Cilag Gmbh International Surgical instrument comprising an articulation lock
US11903581B2 (en) 2019-04-30 2024-02-20 Cilag Gmbh International Methods for stapling tissue using a surgical instrument
US11903582B2 (en) 2021-03-24 2024-02-20 Cilag Gmbh International Leveraging surfaces for cartridge installation
US11911032B2 (en) 2019-12-19 2024-02-27 Cilag Gmbh International Staple cartridge comprising a seating cam
US11918212B2 (en) 2015-03-31 2024-03-05 Cilag Gmbh International Surgical instrument with selectively disengageable drive systems
US11918220B2 (en) 2012-03-28 2024-03-05 Cilag Gmbh International Tissue thickness compensator comprising tissue ingrowth features
US11925349B2 (en) 2021-02-26 2024-03-12 Cilag Gmbh International Adjustment to transfer parameters to improve available power
US11931033B2 (en) 2019-12-19 2024-03-19 Cilag Gmbh International Staple cartridge comprising a latch lockout
US11931025B2 (en) 2020-10-29 2024-03-19 Cilag Gmbh International Surgical instrument comprising a releasable closure drive lock
US11937816B2 (en) 2021-10-28 2024-03-26 Cilag Gmbh International Electrical lead arrangements for surgical instruments
US11944336B2 (en) 2021-03-24 2024-04-02 Cilag Gmbh International Joint arrangements for multi-planar alignment and support of operational drive shafts in articulatable surgical instruments
US11944296B2 (en) 2020-12-02 2024-04-02 Cilag Gmbh International Powered surgical instruments with external connectors
US11944338B2 (en) 2015-03-06 2024-04-02 Cilag Gmbh International Multiple level thresholds to modify operation of powered surgical instruments
US11944300B2 (en) 2017-08-03 2024-04-02 Cilag Gmbh International Method for operating a surgical system bailout
US11950779B2 (en) 2021-02-26 2024-04-09 Cilag Gmbh International Method of powering and communicating with a staple cartridge
US11950777B2 (en) 2021-02-26 2024-04-09 Cilag Gmbh International Staple cartridge comprising an information access control system
US11957337B2 (en) 2021-10-18 2024-04-16 Cilag Gmbh International Surgical stapling assembly with offset ramped drive surfaces
US11974742B2 (en) 2017-08-03 2024-05-07 Cilag Gmbh International Surgical system comprising an articulation bailout
US11980366B2 (en) 2006-10-03 2024-05-14 Cilag Gmbh International Surgical instrument
US11980362B2 (en) 2021-02-26 2024-05-14 Cilag Gmbh International Surgical instrument system comprising a power transfer coil
US11980363B2 (en) 2021-10-18 2024-05-14 Cilag Gmbh International Row-to-row staple array variations
US11986183B2 (en) 2008-02-14 2024-05-21 Cilag Gmbh International Surgical cutting and fastening instrument comprising a plurality of sensors to measure an electrical parameter
US11998198B2 (en) 2004-07-28 2024-06-04 Cilag Gmbh International Surgical stapling instrument incorporating a two-piece E-beam firing mechanism
US12004745B2 (en) 2016-12-21 2024-06-11 Cilag Gmbh International Surgical instrument system comprising an end effector lockout and a firing assembly lockout
US12004740B2 (en) 2019-06-28 2024-06-11 Cilag Gmbh International Surgical stapling system having an information decryption protocol
US12016564B2 (en) 2014-09-26 2024-06-25 Cilag Gmbh International Circular fastener cartridges for applying radially expandable fastener lines
US12035913B2 (en) 2019-12-19 2024-07-16 Cilag Gmbh International Staple cartridge comprising a deployable knife
US12053175B2 (en) 2020-10-29 2024-08-06 Cilag Gmbh International Surgical instrument comprising a stowed closure actuator stop
US12089841B2 (en) 2021-10-28 2024-09-17 Cilag CmbH International Staple cartridge identification systems
US12102323B2 (en) 2021-03-24 2024-10-01 Cilag Gmbh International Rotary-driven surgical stapling assembly comprising a floatable component
US12108951B2 (en) 2021-02-26 2024-10-08 Cilag Gmbh International Staple cartridge comprising a sensing array and a temperature control system
US12114859B2 (en) 2022-05-26 2024-10-15 Cilag Gmbh International Articulatable surgical instrument system

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN2518505Y (zh) * 2002-02-05 2002-10-30 张俊杰 一种眼药瓶

Cited By (760)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US10799240B2 (en) 2004-07-28 2020-10-13 Ethicon Llc Surgical instrument comprising a staple firing lockout
US10687817B2 (en) 2004-07-28 2020-06-23 Ethicon Llc Stapling device comprising a firing member lockout
US10716563B2 (en) 2004-07-28 2020-07-21 Ethicon Llc Stapling system comprising an instrument assembly including a lockout
US11963679B2 (en) 2004-07-28 2024-04-23 Cilag Gmbh International Articulating surgical stapling instrument incorporating a two-piece E-beam firing mechanism
US11684365B2 (en) 2004-07-28 2023-06-27 Cilag Gmbh International Replaceable staple cartridges for surgical instruments
US11882987B2 (en) 2004-07-28 2024-01-30 Cilag Gmbh International Articulating surgical stapling instrument incorporating a two-piece E-beam firing mechanism
US11083456B2 (en) 2004-07-28 2021-08-10 Cilag Gmbh International Articulating surgical instrument incorporating a two-piece firing mechanism
US11890012B2 (en) 2004-07-28 2024-02-06 Cilag Gmbh International Staple cartridge comprising cartridge body and attached support
US11998198B2 (en) 2004-07-28 2024-06-04 Cilag Gmbh International Surgical stapling instrument incorporating a two-piece E-beam firing mechanism
US11116502B2 (en) 2004-07-28 2021-09-14 Cilag Gmbh International Surgical stapling instrument incorporating a two-piece firing mechanism
US12011165B2 (en) 2004-07-28 2024-06-18 Cilag Gmbh International Surgical stapling instrument comprising replaceable staple cartridge
US11896225B2 (en) 2004-07-28 2024-02-13 Cilag Gmbh International Staple cartridge comprising a pan
US11135352B2 (en) 2004-07-28 2021-10-05 Cilag Gmbh International End effector including a gradually releasable medical adjunct
US12029423B2 (en) 2004-07-28 2024-07-09 Cilag Gmbh International Surgical stapling instrument comprising a staple cartridge
US11812960B2 (en) 2004-07-28 2023-11-14 Cilag Gmbh International Method of segmenting the operation of a surgical stapling instrument
US11771425B2 (en) 2005-08-31 2023-10-03 Cilag Gmbh International Stapling assembly for forming staples to different formed heights
US10842489B2 (en) 2005-08-31 2020-11-24 Ethicon Llc Fastener cartridge assembly comprising a cam and driver arrangement
US11399828B2 (en) 2005-08-31 2022-08-02 Cilag Gmbh International Fastener cartridge assembly comprising a fixed anvil and different staple heights
US11839375B2 (en) 2005-08-31 2023-12-12 Cilag Gmbh International Fastener cartridge assembly comprising an anvil and different staple heights
US11090045B2 (en) 2005-08-31 2021-08-17 Cilag Gmbh International Staple cartridges for forming staples having differing formed staple heights
US11246590B2 (en) 2005-08-31 2022-02-15 Cilag Gmbh International Staple cartridge including staple drivers having different unfired heights
US10932774B2 (en) 2005-08-31 2021-03-02 Ethicon Llc Surgical end effector for forming staples to different heights
US11730474B2 (en) 2005-08-31 2023-08-22 Cilag Gmbh International Fastener cartridge assembly comprising a movable cartridge and a staple driver arrangement
US11134947B2 (en) 2005-08-31 2021-10-05 Cilag Gmbh International Fastener cartridge assembly comprising a camming sled with variable cam arrangements
US11172927B2 (en) 2005-08-31 2021-11-16 Cilag Gmbh International Staple cartridges for forming staples having differing formed staple heights
US11484312B2 (en) 2005-08-31 2022-11-01 Cilag Gmbh International Staple cartridge comprising a staple driver arrangement
US11484311B2 (en) 2005-08-31 2022-11-01 Cilag Gmbh International Staple cartridge comprising a staple driver arrangement
US11272928B2 (en) 2005-08-31 2022-03-15 Cilag GmbH Intemational Staple cartridges for forming staples having differing formed staple heights
US11576673B2 (en) 2005-08-31 2023-02-14 Cilag Gmbh International Stapling assembly for forming staples to different heights
US11179153B2 (en) 2005-08-31 2021-11-23 Cilag Gmbh International Staple cartridges for forming staples having differing formed staple heights
US11793512B2 (en) 2005-08-31 2023-10-24 Cilag Gmbh International Staple cartridges for forming staples having differing formed staple heights
US10993713B2 (en) 2005-11-09 2021-05-04 Ethicon Llc Surgical instruments
US11793511B2 (en) 2005-11-09 2023-10-24 Cilag Gmbh International Surgical instruments
US10806449B2 (en) 2005-11-09 2020-10-20 Ethicon Llc End effectors for surgical staplers
US11278279B2 (en) 2006-01-31 2022-03-22 Cilag Gmbh International Surgical instrument assembly
US11944299B2 (en) 2006-01-31 2024-04-02 Cilag Gmbh International Surgical instrument having force feedback capabilities
US11166717B2 (en) 2006-01-31 2021-11-09 Cilag Gmbh International Surgical instrument with firing lockout
US10993717B2 (en) 2006-01-31 2021-05-04 Ethicon Llc Surgical stapling system comprising a control system
US11793518B2 (en) 2006-01-31 2023-10-24 Cilag Gmbh International Powered surgical instruments with firing system lockout arrangements
US11000275B2 (en) 2006-01-31 2021-05-11 Ethicon Llc Surgical instrument
US11612393B2 (en) 2006-01-31 2023-03-28 Cilag Gmbh International Robotically-controlled end effector
US10918380B2 (en) 2006-01-31 2021-02-16 Ethicon Llc Surgical instrument system including a control system
US11020113B2 (en) 2006-01-31 2021-06-01 Cilag Gmbh International Surgical instrument having force feedback capabilities
US10743849B2 (en) 2006-01-31 2020-08-18 Ethicon Llc Stapling system including an articulation system
US11648008B2 (en) 2006-01-31 2023-05-16 Cilag Gmbh International Surgical instrument having force feedback capabilities
US11224454B2 (en) 2006-01-31 2022-01-18 Cilag Gmbh International Motor-driven surgical cutting and fastening instrument with tactile position feedback
US10952728B2 (en) 2006-01-31 2021-03-23 Ethicon Llc Powered surgical instruments with firing system lockout arrangements
US11224427B2 (en) 2006-01-31 2022-01-18 Cilag Gmbh International Surgical stapling system including a console and retraction assembly
US11890029B2 (en) 2006-01-31 2024-02-06 Cilag Gmbh International Motor-driven surgical cutting and fastening instrument
US11801051B2 (en) 2006-01-31 2023-10-31 Cilag Gmbh International Accessing data stored in a memory of a surgical instrument
US11890008B2 (en) 2006-01-31 2024-02-06 Cilag Gmbh International Surgical instrument with firing lockout
US10653435B2 (en) 2006-01-31 2020-05-19 Ethicon Llc Motor-driven surgical cutting and fastening instrument with tactile position feedback
US10806479B2 (en) 2006-01-31 2020-10-20 Ethicon Llc Motor-driven surgical cutting and fastening instrument with tactile position feedback
US11051813B2 (en) 2006-01-31 2021-07-06 Cilag Gmbh International Powered surgical instruments with firing system lockout arrangements
US11058420B2 (en) 2006-01-31 2021-07-13 Cilag Gmbh International Surgical stapling apparatus comprising a lockout system
US10675028B2 (en) 2006-01-31 2020-06-09 Ethicon Llc Powered surgical instruments with firing system lockout arrangements
US11883020B2 (en) 2006-01-31 2024-01-30 Cilag Gmbh International Surgical instrument having a feedback system
US11350916B2 (en) 2006-01-31 2022-06-07 Cilag Gmbh International Endoscopic surgical instrument with a handle that can articulate with respect to the shaft
US11364046B2 (en) 2006-01-31 2022-06-21 Cilag Gmbh International Motor-driven surgical cutting and fastening instrument with tactile position feedback
US10893853B2 (en) 2006-01-31 2021-01-19 Ethicon Llc Stapling assembly including motor drive systems
US11246616B2 (en) 2006-01-31 2022-02-15 Cilag Gmbh International Motor-driven surgical cutting and fastening instrument with tactile position feedback
US10709468B2 (en) 2006-01-31 2020-07-14 Ethicon Llc Motor-driven surgical cutting and fastening instrument
US11648024B2 (en) 2006-01-31 2023-05-16 Cilag Gmbh International Motor-driven surgical cutting and fastening instrument with position feedback
US11103269B2 (en) 2006-01-31 2021-08-31 Cilag Gmbh International Motor-driven surgical cutting and fastening instrument with tactile position feedback
US11660110B2 (en) 2006-01-31 2023-05-30 Cilag Gmbh International Motor-driven surgical cutting and fastening instrument with tactile position feedback
US11272938B2 (en) 2006-06-27 2022-03-15 Cilag Gmbh International Surgical instrument including dedicated firing and retraction assemblies
US11622785B2 (en) 2006-09-29 2023-04-11 Cilag Gmbh International Surgical staples having attached drivers and stapling instruments for deploying the same
US11571231B2 (en) 2006-09-29 2023-02-07 Cilag Gmbh International Staple cartridge having a driver for driving multiple staples
US11382626B2 (en) 2006-10-03 2022-07-12 Cilag Gmbh International Surgical system including a knife bar supported for rotational and axial travel
US11877748B2 (en) 2006-10-03 2024-01-23 Cilag Gmbh International Robotically-driven surgical instrument with E-beam driver
US11980366B2 (en) 2006-10-03 2024-05-14 Cilag Gmbh International Surgical instrument
US11844521B2 (en) 2007-01-10 2023-12-19 Cilag Gmbh International Surgical instrument for use with a robotic system
US11064998B2 (en) 2007-01-10 2021-07-20 Cilag Gmbh International Surgical instrument with wireless communication between a control unit of a robotic system and remote sensor
US11350929B2 (en) 2007-01-10 2022-06-07 Cilag Gmbh International Surgical instrument with wireless communication between control unit and sensor transponders
US11937814B2 (en) 2007-01-10 2024-03-26 Cilag Gmbh International Surgical instrument for use with a robotic system
US11931032B2 (en) 2007-01-10 2024-03-19 Cilag Gmbh International Surgical instrument with wireless communication between a control unit of a robotic system and remote sensor
US11006951B2 (en) 2007-01-10 2021-05-18 Ethicon Llc Surgical instrument with wireless communication between control unit and sensor transponders
US10918386B2 (en) 2007-01-10 2021-02-16 Ethicon Llc Interlock and surgical instrument including same
US11291441B2 (en) 2007-01-10 2022-04-05 Cilag Gmbh International Surgical instrument with wireless communication between control unit and remote sensor
US10945729B2 (en) 2007-01-10 2021-03-16 Ethicon Llc Interlock and surgical instrument including same
US12082806B2 (en) 2007-01-10 2024-09-10 Cilag Gmbh International Surgical instrument with wireless communication between control unit and sensor transponders
US11000277B2 (en) 2007-01-10 2021-05-11 Ethicon Llc Surgical instrument with wireless communication between control unit and remote sensor
US11849947B2 (en) 2007-01-10 2023-12-26 Cilag Gmbh International Surgical system including a control circuit and a passively-powered transponder
US11134943B2 (en) 2007-01-10 2021-10-05 Cilag Gmbh International Powered surgical instrument including a control unit and sensor
US10952727B2 (en) 2007-01-10 2021-03-23 Ethicon Llc Surgical instrument for assessing the state of a staple cartridge
US11918211B2 (en) 2007-01-10 2024-03-05 Cilag Gmbh International Surgical stapling instrument for use with a robotic system
US11812961B2 (en) 2007-01-10 2023-11-14 Cilag Gmbh International Surgical instrument including a motor control system
US11166720B2 (en) 2007-01-10 2021-11-09 Cilag Gmbh International Surgical instrument including a control module for assessing an end effector
US11771426B2 (en) 2007-01-10 2023-10-03 Cilag Gmbh International Surgical instrument with wireless communication
US11666332B2 (en) 2007-01-10 2023-06-06 Cilag Gmbh International Surgical instrument comprising a control circuit configured to adjust the operation of a motor
US12004743B2 (en) 2007-01-10 2024-06-11 Cilag Gmbh International Staple cartridge comprising a sloped wall
US11039836B2 (en) 2007-01-11 2021-06-22 Cilag Gmbh International Staple cartridge for use with a surgical stapling instrument
US11839352B2 (en) 2007-01-11 2023-12-12 Cilag Gmbh International Surgical stapling device with an end effector
US10702267B2 (en) 2007-03-15 2020-07-07 Ethicon Llc Surgical stapling instrument having a releasable buttress material
US11337693B2 (en) 2007-03-15 2022-05-24 Cilag Gmbh International Surgical stapling instrument having a releasable buttress material
US11857181B2 (en) 2007-06-04 2024-01-02 Cilag Gmbh International Robotically-controlled shaft based rotary drive systems for surgical instruments
US11672531B2 (en) 2007-06-04 2023-06-13 Cilag Gmbh International Rotary drive systems for surgical instruments
US11154298B2 (en) 2007-06-04 2021-10-26 Cilag Gmbh International Stapling system for use with a robotic surgical system
US11992208B2 (en) 2007-06-04 2024-05-28 Cilag Gmbh International Rotary drive systems for surgical instruments
US11134938B2 (en) 2007-06-04 2021-10-05 Cilag Gmbh International Robotically-controlled shaft based rotary drive systems for surgical instruments
US11648006B2 (en) 2007-06-04 2023-05-16 Cilag Gmbh International Robotically-controlled shaft based rotary drive systems for surgical instruments
US11911028B2 (en) 2007-06-04 2024-02-27 Cilag Gmbh International Surgical instruments for use with a robotic surgical system
US11559302B2 (en) 2007-06-04 2023-01-24 Cilag Gmbh International Surgical instrument including a firing member movable at different speeds
US11147549B2 (en) 2007-06-04 2021-10-19 Cilag Gmbh International Stapling instrument including a firing system and a closure system
US12023024B2 (en) 2007-06-04 2024-07-02 Cilag Gmbh International Robotically-controlled shaft based rotary drive systems for surgical instruments
US11564682B2 (en) 2007-06-04 2023-01-31 Cilag Gmbh International Surgical stapler device
US12035906B2 (en) 2007-06-04 2024-07-16 Cilag Gmbh International Surgical instrument including a handle system for advancing a cutting member
US11998200B2 (en) 2007-06-22 2024-06-04 Cilag Gmbh International Surgical stapling instrument with an articulatable end effector
US11013511B2 (en) 2007-06-22 2021-05-25 Ethicon Llc Surgical stapling instrument with an articulatable end effector
US11849941B2 (en) 2007-06-29 2023-12-26 Cilag Gmbh International Staple cartridge having staple cavities extending at a transverse angle relative to a longitudinal cartridge axis
US12023025B2 (en) 2007-06-29 2024-07-02 Cilag Gmbh International Surgical stapling instrument having a releasable buttress material
US11925346B2 (en) 2007-06-29 2024-03-12 Cilag Gmbh International Surgical staple cartridge including tissue supporting surfaces
US11998206B2 (en) 2008-02-14 2024-06-04 Cilag Gmbh International Detachable motor powered surgical instrument
US10716568B2 (en) 2008-02-14 2020-07-21 Ethicon Llc Surgical stapling apparatus with control features operable with one hand
US11717285B2 (en) 2008-02-14 2023-08-08 Cilag Gmbh International Surgical cutting and fastening instrument having RF electrodes
US10542974B2 (en) 2008-02-14 2020-01-28 Ethicon Llc Surgical instrument including a control system
US10806450B2 (en) 2008-02-14 2020-10-20 Ethicon Llc Surgical cutting and fastening instrument having a control system
US10888329B2 (en) 2008-02-14 2021-01-12 Ethicon Llc Detachable motor powered surgical instrument
US11571212B2 (en) 2008-02-14 2023-02-07 Cilag Gmbh International Surgical stapling system including an impedance sensor
US10682142B2 (en) 2008-02-14 2020-06-16 Ethicon Llc Surgical stapling apparatus including an articulation system
US11801047B2 (en) 2008-02-14 2023-10-31 Cilag Gmbh International Surgical stapling system comprising a control circuit configured to selectively monitor tissue impedance and adjust control of a motor
US10660640B2 (en) 2008-02-14 2020-05-26 Ethicon Llc Motorized surgical cutting and fastening instrument
US10925605B2 (en) 2008-02-14 2021-02-23 Ethicon Llc Surgical stapling system
US10722232B2 (en) 2008-02-14 2020-07-28 Ethicon Llc Surgical instrument for use with different cartridges
US10743870B2 (en) 2008-02-14 2020-08-18 Ethicon Llc Surgical stapling apparatus with interlockable firing system
US10639036B2 (en) 2008-02-14 2020-05-05 Ethicon Llc Robotically-controlled motorized surgical cutting and fastening instrument
US11484307B2 (en) 2008-02-14 2022-11-01 Cilag Gmbh International Loading unit coupleable to a surgical stapling system
US11986183B2 (en) 2008-02-14 2024-05-21 Cilag Gmbh International Surgical cutting and fastening instrument comprising a plurality of sensors to measure an electrical parameter
US11464514B2 (en) 2008-02-14 2022-10-11 Cilag Gmbh International Motorized surgical stapling system including a sensing array
US10743851B2 (en) 2008-02-14 2020-08-18 Ethicon Llc Interchangeable tools for surgical instruments
US10682141B2 (en) 2008-02-14 2020-06-16 Ethicon Llc Surgical device including a control system
US11446034B2 (en) 2008-02-14 2022-09-20 Cilag Gmbh International Surgical stapling assembly comprising first and second actuation systems configured to perform different functions
US10765432B2 (en) 2008-02-14 2020-09-08 Ethicon Llc Surgical device including a control system
US10888330B2 (en) 2008-02-14 2021-01-12 Ethicon Llc Surgical system
US10905426B2 (en) 2008-02-14 2021-02-02 Ethicon Llc Detachable motor powered surgical instrument
US10905427B2 (en) 2008-02-14 2021-02-02 Ethicon Llc Surgical System
US10898195B2 (en) 2008-02-14 2021-01-26 Ethicon Llc Detachable motor powered surgical instrument
US11612395B2 (en) 2008-02-14 2023-03-28 Cilag Gmbh International Surgical system including a control system having an RFID tag reader
US10874396B2 (en) 2008-02-14 2020-12-29 Ethicon Llc Stapling instrument for use with a surgical robot
US11638583B2 (en) 2008-02-14 2023-05-02 Cilag Gmbh International Motorized surgical system having a plurality of power sources
US10898194B2 (en) 2008-02-14 2021-01-26 Ethicon Llc Detachable motor powered surgical instrument
US11154297B2 (en) 2008-02-15 2021-10-26 Cilag Gmbh International Layer arrangements for surgical staple cartridges
US11998194B2 (en) 2008-02-15 2024-06-04 Cilag Gmbh International Surgical stapling assembly comprising an adjunct applicator
CN101969913A (zh) * 2008-03-14 2011-02-09 株式会社大塚制药工厂 塑料安瓿以及着色塑料容器
CN102836066A (zh) * 2008-03-14 2012-12-26 株式会社大塚制药工厂 塑料安瓿以及着色塑料容器
CN101969913B (zh) * 2008-03-14 2013-10-16 株式会社大塚制药工厂 塑料安瓿
US10980535B2 (en) 2008-09-23 2021-04-20 Ethicon Llc Motorized surgical instrument with an end effector
US11617576B2 (en) 2008-09-23 2023-04-04 Cilag Gmbh International Motor-driven surgical cutting instrument
US10765425B2 (en) 2008-09-23 2020-09-08 Ethicon Llc Robotically-controlled motorized surgical instrument with an end effector
US11406380B2 (en) 2008-09-23 2022-08-09 Cilag Gmbh International Motorized surgical instrument
US11648005B2 (en) 2008-09-23 2023-05-16 Cilag Gmbh International Robotically-controlled motorized surgical instrument with an end effector
US11684361B2 (en) 2008-09-23 2023-06-27 Cilag Gmbh International Motor-driven surgical cutting instrument
US11617575B2 (en) 2008-09-23 2023-04-04 Cilag Gmbh International Motor-driven surgical cutting instrument
US10736628B2 (en) 2008-09-23 2020-08-11 Ethicon Llc Motor-driven surgical cutting instrument
US10898184B2 (en) 2008-09-23 2021-01-26 Ethicon Llc Motor-driven surgical cutting instrument
US11871923B2 (en) 2008-09-23 2024-01-16 Cilag Gmbh International Motorized surgical instrument
US11045189B2 (en) 2008-09-23 2021-06-29 Cilag Gmbh International Robotically-controlled motorized surgical instrument with an end effector
US11103241B2 (en) 2008-09-23 2021-08-31 Cilag Gmbh International Motor-driven surgical cutting instrument
US11517304B2 (en) 2008-09-23 2022-12-06 Cilag Gmbh International Motor-driven surgical cutting instrument
US11812954B2 (en) 2008-09-23 2023-11-14 Cilag Gmbh International Robotically-controlled motorized surgical instrument with an end effector
US12029415B2 (en) 2008-09-23 2024-07-09 Cilag Gmbh International Motor-driven surgical cutting instrument
US11730477B2 (en) 2008-10-10 2023-08-22 Cilag Gmbh International Powered surgical system with manually retractable firing system
US11583279B2 (en) 2008-10-10 2023-02-21 Cilag Gmbh International Powered surgical cutting and stapling apparatus with manually retractable firing system
US11793521B2 (en) 2008-10-10 2023-10-24 Cilag Gmbh International Powered surgical cutting and stapling apparatus with manually retractable firing system
US10932778B2 (en) 2008-10-10 2021-03-02 Ethicon Llc Powered surgical cutting and stapling apparatus with manually retractable firing system
US11129615B2 (en) 2009-02-05 2021-09-28 Cilag Gmbh International Surgical stapling system
CN102639095A (zh) * 2009-10-02 2012-08-15 株式会社细川洋行 存储容器
US11291449B2 (en) 2009-12-24 2022-04-05 Cilag Gmbh International Surgical cutting instrument that analyzes tissue thickness
US10751076B2 (en) 2009-12-24 2020-08-25 Ethicon Llc Motor-driven surgical cutting instrument with electric actuator directional control assembly
US11478247B2 (en) 2010-07-30 2022-10-25 Cilag Gmbh International Tissue acquisition arrangements and methods for surgical stapling devices
CN102229225A (zh) * 2010-08-27 2011-11-02 上海海昌医用塑胶厂 一种抗跌落coc塑料瓶的制作方法
US11957795B2 (en) 2010-09-30 2024-04-16 Cilag Gmbh International Tissue thickness compensator configured to redistribute compressive forces
US11406377B2 (en) 2010-09-30 2022-08-09 Cilag Gmbh International Adhesive film laminate
US11911027B2 (en) 2010-09-30 2024-02-27 Cilag Gmbh International Adhesive film laminate
US11672536B2 (en) 2010-09-30 2023-06-13 Cilag Gmbh International Layer of material for a surgical end effector
US11850310B2 (en) 2010-09-30 2023-12-26 Cilag Gmbh International Staple cartridge including an adjunct
US11559496B2 (en) 2010-09-30 2023-01-24 Cilag Gmbh International Tissue thickness compensator configured to redistribute compressive forces
US11540824B2 (en) 2010-09-30 2023-01-03 Cilag Gmbh International Tissue thickness compensator
US10945731B2 (en) 2010-09-30 2021-03-16 Ethicon Llc Tissue thickness compensator comprising controlled release and expansion
US10624861B2 (en) 2010-09-30 2020-04-21 Ethicon Llc Tissue thickness compensator configured to redistribute compressive forces
US11684360B2 (en) 2010-09-30 2023-06-27 Cilag Gmbh International Staple cartridge comprising a variable thickness compressible portion
US11571215B2 (en) 2010-09-30 2023-02-07 Cilag Gmbh International Layer of material for a surgical end effector
US11583277B2 (en) 2010-09-30 2023-02-21 Cilag Gmbh International Layer of material for a surgical end effector
US11812965B2 (en) 2010-09-30 2023-11-14 Cilag Gmbh International Layer of material for a surgical end effector
US11154296B2 (en) 2010-09-30 2021-10-26 Cilag Gmbh International Anvil layer attached to a proximal end of an end effector
US10835251B2 (en) 2010-09-30 2020-11-17 Ethicon Llc Surgical instrument assembly including an end effector configurable in different positions
US10888328B2 (en) 2010-09-30 2021-01-12 Ethicon Llc Surgical end effector
US11083452B2 (en) 2010-09-30 2021-08-10 Cilag Gmbh International Staple cartridge including a tissue thickness compensator
US10898193B2 (en) 2010-09-30 2021-01-26 Ethicon Llc End effector for use with a surgical instrument
US11883025B2 (en) 2010-09-30 2024-01-30 Cilag Gmbh International Tissue thickness compensator comprising a plurality of layers
US11849952B2 (en) 2010-09-30 2023-12-26 Cilag Gmbh International Staple cartridge comprising staples positioned within a compressible portion thereof
US11737754B2 (en) 2010-09-30 2023-08-29 Cilag Gmbh International Surgical stapler with floating anvil
US11298125B2 (en) 2010-09-30 2022-04-12 Cilag Gmbh International Tissue stapler having a thickness compensator
US11944292B2 (en) 2010-09-30 2024-04-02 Cilag Gmbh International Anvil layer attached to a proximal end of an end effector
US10987102B2 (en) 2010-09-30 2021-04-27 Ethicon Llc Tissue thickness compensator comprising a plurality of layers
US10743877B2 (en) 2010-09-30 2020-08-18 Ethicon Llc Surgical stapler with floating anvil
US11395651B2 (en) 2010-09-30 2022-07-26 Cilag Gmbh International Adhesive film laminate
US11602340B2 (en) 2010-09-30 2023-03-14 Cilag Gmbh International Adhesive film laminate
US11857187B2 (en) 2010-09-30 2024-01-02 Cilag Gmbh International Tissue thickness compensator comprising controlled release and expansion
US11925354B2 (en) 2010-09-30 2024-03-12 Cilag Gmbh International Staple cartridge comprising staples positioned within a compressible portion thereof
US10695062B2 (en) 2010-10-01 2020-06-30 Ethicon Llc Surgical instrument including a retractable firing member
US11529142B2 (en) 2010-10-01 2022-12-20 Cilag Gmbh International Surgical instrument having a power control circuit
CN103458849A (zh) * 2011-04-06 2013-12-18 株式会社大塚制药工厂 塑料安瓿
US11504116B2 (en) 2011-04-29 2022-11-22 Cilag Gmbh International Layer of material for a surgical end effector
CN102274122A (zh) * 2011-05-20 2011-12-14 海南卫康制药(潜山)有限公司 适用于注射剂药品的包装瓶
US11918208B2 (en) 2011-05-27 2024-03-05 Cilag Gmbh International Robotically-controlled shaft based rotary drive systems for surgical instruments
US11129616B2 (en) 2011-05-27 2021-09-28 Cilag Gmbh International Surgical stapling system
US10736634B2 (en) 2011-05-27 2020-08-11 Ethicon Llc Robotically-driven surgical instrument including a drive system
US11612394B2 (en) 2011-05-27 2023-03-28 Cilag Gmbh International Automated end effector component reloading system for use with a robotic system
US11266410B2 (en) 2011-05-27 2022-03-08 Cilag Gmbh International Surgical device for use with a robotic system
US10813641B2 (en) 2011-05-27 2020-10-27 Ethicon Llc Robotically-driven surgical instrument
US11207064B2 (en) 2011-05-27 2021-12-28 Cilag Gmbh International Automated end effector component reloading system for use with a robotic system
US11583278B2 (en) 2011-05-27 2023-02-21 Cilag Gmbh International Surgical stapling system having multi-direction articulation
US10617420B2 (en) 2011-05-27 2020-04-14 Ethicon Llc Surgical system comprising drive systems
US12059154B2 (en) 2011-05-27 2024-08-13 Cilag Gmbh International Surgical instrument with detachable motor control unit
US11974747B2 (en) 2011-05-27 2024-05-07 Cilag Gmbh International Surgical stapling instruments with rotatable staple deployment arrangements
US11439470B2 (en) 2011-05-27 2022-09-13 Cilag Gmbh International Robotically-controlled surgical instrument with selectively articulatable end effector
US10980534B2 (en) 2011-05-27 2021-04-20 Ethicon Llc Robotically-controlled motorized surgical instrument with an end effector
US10780539B2 (en) 2011-05-27 2020-09-22 Ethicon Llc Stapling instrument for use with a robotic system
CN103619305B (zh) * 2011-06-30 2016-03-16 赛多利斯史泰迪生物技术有限责任公司 生物反应容器和用于生物反应容器的完整性检测方法
CN103619305A (zh) * 2011-06-30 2014-03-05 赛多利斯史泰迪生物技术有限责任公司 生物反应容器和用于生物反应容器的完整性检测方法
CN102249174A (zh) * 2011-07-04 2011-11-23 楚天科技股份有限公司 一种塑料安瓿的成型装置
CN102249174B (zh) * 2011-07-04 2012-11-07 楚天科技股份有限公司 一种塑料安瓿的成型装置
CN103796625B (zh) * 2011-07-14 2016-11-23 K·C·马塔 具有专用瓶头和密封件的便携式安瓿
CN103796625A (zh) * 2011-07-14 2014-05-14 K·C·马塔 具有专用瓶头和密封件的便携式安瓿
CN102431946B (zh) * 2011-11-17 2013-12-04 楚天科技股份有限公司 一种塑料安瓿吹灌封一体机
CN102515071B (zh) * 2011-11-17 2014-01-29 楚天科技股份有限公司 塑料安瓿吹灌封一体机
CN102515071A (zh) * 2011-11-17 2012-06-27 楚天科技股份有限公司 塑料安瓿吹灌封一体机
CN102431946A (zh) * 2011-11-17 2012-05-02 楚天科技股份有限公司 一种塑料安瓿吹灌封一体机
US10695063B2 (en) 2012-02-13 2020-06-30 Ethicon Llc Surgical cutting and fastening instrument with apparatus for determining cartridge and firing motion status
CN103315907A (zh) * 2012-03-19 2013-09-25 宝丽制药股份有限公司 填充有抗真菌药物组合物的树脂容器
US10667808B2 (en) 2012-03-28 2020-06-02 Ethicon Llc Staple cartridge comprising an absorbable adjunct
CN104379069A (zh) * 2012-03-28 2015-02-25 伊西康内外科公司 包括贮存器的组织厚度补偿件
US11793509B2 (en) 2012-03-28 2023-10-24 Cilag Gmbh International Staple cartridge including an implantable layer
US11918220B2 (en) 2012-03-28 2024-03-05 Cilag Gmbh International Tissue thickness compensator comprising tissue ingrowth features
US11406378B2 (en) 2012-03-28 2022-08-09 Cilag Gmbh International Staple cartridge comprising a compressible tissue thickness compensator
US11707273B2 (en) 2012-06-15 2023-07-25 Cilag Gmbh International Articulatable surgical instrument comprising a firing drive
US10959725B2 (en) 2012-06-15 2021-03-30 Ethicon Llc Articulatable surgical instrument comprising a firing drive
US10932775B2 (en) 2012-06-28 2021-03-02 Ethicon Llc Firing system lockout arrangements for surgical instruments
US11779420B2 (en) 2012-06-28 2023-10-10 Cilag Gmbh International Robotic surgical attachments having manually-actuated retraction assemblies
US11857189B2 (en) 2012-06-28 2024-01-02 Cilag Gmbh International Surgical instrument including first and second articulation joints
US11083457B2 (en) 2012-06-28 2021-08-10 Cilag Gmbh International Surgical instrument system including replaceable end effectors
US11197671B2 (en) 2012-06-28 2021-12-14 Cilag Gmbh International Stapling assembly comprising a lockout
US11241230B2 (en) 2012-06-28 2022-02-08 Cilag Gmbh International Clip applier tool for use with a robotic surgical system
US11278284B2 (en) 2012-06-28 2022-03-22 Cilag Gmbh International Rotary drive arrangements for surgical instruments
US11141155B2 (en) 2012-06-28 2021-10-12 Cilag Gmbh International Drive system for surgical tool
US11202631B2 (en) 2012-06-28 2021-12-21 Cilag Gmbh International Stapling assembly comprising a firing lockout
US11534162B2 (en) 2012-06-28 2022-12-27 Cilag GmbH Inlernational Robotically powered surgical device with manually-actuatable reversing system
US10874391B2 (en) 2012-06-28 2020-12-29 Ethicon Llc Surgical instrument system including replaceable end effectors
US11141156B2 (en) 2012-06-28 2021-10-12 Cilag Gmbh International Surgical stapling assembly comprising flexible output shaft
US11058423B2 (en) 2012-06-28 2021-07-13 Cilag Gmbh International Stapling system including first and second closure systems for use with a surgical robot
US11540829B2 (en) 2012-06-28 2023-01-03 Cilag Gmbh International Surgical instrument system including replaceable end effectors
US11109860B2 (en) 2012-06-28 2021-09-07 Cilag Gmbh International Surgical end effectors for use with hand-held and robotically-controlled rotary powered surgical systems
US11039837B2 (en) 2012-06-28 2021-06-22 Cilag Gmbh International Firing system lockout arrangements for surgical instruments
US11622766B2 (en) 2012-06-28 2023-04-11 Cilag Gmbh International Empty clip cartridge lockout
US11464513B2 (en) 2012-06-28 2022-10-11 Cilag Gmbh International Surgical instrument system including replaceable end effectors
US11510671B2 (en) 2012-06-28 2022-11-29 Cilag Gmbh International Firing system lockout arrangements for surgical instruments
US11154299B2 (en) 2012-06-28 2021-10-26 Cilag Gmbh International Stapling assembly comprising a firing lockout
US11602346B2 (en) 2012-06-28 2023-03-14 Cilag Gmbh International Robotically powered surgical device with manually-actuatable reversing system
US11806013B2 (en) 2012-06-28 2023-11-07 Cilag Gmbh International Firing system arrangements for surgical instruments
US10687812B2 (en) 2012-06-28 2020-06-23 Ethicon Llc Surgical instrument system including replaceable end effectors
US11918213B2 (en) 2012-06-28 2024-03-05 Cilag Gmbh International Surgical stapler including couplers for attaching a shaft to an end effector
US11373755B2 (en) 2012-08-23 2022-06-28 Cilag Gmbh International Surgical device drive system including a ratchet mechanism
US11957345B2 (en) 2013-03-01 2024-04-16 Cilag Gmbh International Articulatable surgical instruments with conductive pathways for signal communication
US11246618B2 (en) 2013-03-01 2022-02-15 Cilag Gmbh International Surgical instrument soft stop
US11529138B2 (en) 2013-03-01 2022-12-20 Cilag Gmbh International Powered surgical instrument including a rotary drive screw
US11992214B2 (en) 2013-03-14 2024-05-28 Cilag Gmbh International Control systems for surgical instruments
US10617416B2 (en) 2013-03-14 2020-04-14 Ethicon Llc Control systems for surgical instruments
US11266406B2 (en) 2013-03-14 2022-03-08 Cilag Gmbh International Control systems for surgical instruments
US10893867B2 (en) 2013-03-14 2021-01-19 Ethicon Llc Drive train control arrangements for modular surgical instruments
US11633183B2 (en) 2013-04-16 2023-04-25 Cilag International GmbH Stapling assembly comprising a retraction drive
US11564679B2 (en) 2013-04-16 2023-01-31 Cilag Gmbh International Powered surgical stapler
US11690615B2 (en) 2013-04-16 2023-07-04 Cilag Gmbh International Surgical system including an electric motor and a surgical instrument
US11638581B2 (en) 2013-04-16 2023-05-02 Cilag Gmbh International Powered surgical stapler
US10888318B2 (en) 2013-04-16 2021-01-12 Ethicon Llc Powered surgical stapler
US11395652B2 (en) 2013-04-16 2022-07-26 Cilag Gmbh International Powered surgical stapler
US10702266B2 (en) 2013-04-16 2020-07-07 Ethicon Llc Surgical instrument system
US11406381B2 (en) 2013-04-16 2022-08-09 Cilag Gmbh International Powered surgical stapler
US11622763B2 (en) 2013-04-16 2023-04-11 Cilag Gmbh International Stapling assembly comprising a shiftable drive
US11109858B2 (en) 2013-08-23 2021-09-07 Cilag Gmbh International Surgical instrument including a display which displays the position of a firing element
US11134940B2 (en) 2013-08-23 2021-10-05 Cilag Gmbh International Surgical instrument including a variable speed firing member
US10828032B2 (en) 2013-08-23 2020-11-10 Ethicon Llc End effector detection systems for surgical instruments
US11504119B2 (en) 2013-08-23 2022-11-22 Cilag Gmbh International Surgical instrument including an electronic firing lockout
US11133106B2 (en) 2013-08-23 2021-09-28 Cilag Gmbh International Surgical instrument assembly comprising a retraction assembly
US11026680B2 (en) 2013-08-23 2021-06-08 Cilag Gmbh International Surgical instrument configured to operate in different states
US10898190B2 (en) 2013-08-23 2021-01-26 Ethicon Llc Secondary battery arrangements for powered surgical instruments
US11918209B2 (en) 2013-08-23 2024-03-05 Cilag Gmbh International Torque optimization for surgical instruments
US11376001B2 (en) 2013-08-23 2022-07-05 Cilag Gmbh International Surgical stapling device with rotary multi-turn retraction mechanism
US11000274B2 (en) 2013-08-23 2021-05-11 Ethicon Llc Powered surgical instrument
US10869665B2 (en) 2013-08-23 2020-12-22 Ethicon Llc Surgical instrument system including a control system
US11389160B2 (en) 2013-08-23 2022-07-19 Cilag Gmbh International Surgical system comprising a display
US12053176B2 (en) 2013-08-23 2024-08-06 Cilag Gmbh International End effector detention systems for surgical instruments
US11701110B2 (en) 2013-08-23 2023-07-18 Cilag Gmbh International Surgical instrument including a drive assembly movable in a non-motorized mode of operation
US11020115B2 (en) 2014-02-12 2021-06-01 Cilag Gmbh International Deliverable surgical instrument
CN103830274A (zh) * 2014-03-12 2014-06-04 蒲增军 鸡痘消除涂抹剂
US11259799B2 (en) 2014-03-26 2022-03-01 Cilag Gmbh International Interface systems for use with surgical instruments
US12023023B2 (en) 2014-03-26 2024-07-02 Cilag Gmbh International Interface systems for use with surgical instruments
US11497488B2 (en) 2014-03-26 2022-11-15 Cilag Gmbh International Systems and methods for controlling a segmented circuit
US12023022B2 (en) 2014-03-26 2024-07-02 Cilag Gmbh International Systems and methods for controlling a segmented circuit
US10898185B2 (en) 2014-03-26 2021-01-26 Ethicon Llc Surgical instrument power management through sleep and wake up control
US10863981B2 (en) 2014-03-26 2020-12-15 Ethicon Llc Interface systems for use with surgical instruments
US11266409B2 (en) 2014-04-16 2022-03-08 Cilag Gmbh International Fastener cartridge comprising a sled including longitudinally-staggered ramps
US12089849B2 (en) 2014-04-16 2024-09-17 Cilag Gmbh International Staple cartridges including a projection
US11382627B2 (en) 2014-04-16 2022-07-12 Cilag Gmbh International Surgical stapling assembly comprising a firing member including a lateral extension
US11382625B2 (en) 2014-04-16 2022-07-12 Cilag Gmbh International Fastener cartridge comprising non-uniform fasteners
US11925353B2 (en) 2014-04-16 2024-03-12 Cilag Gmbh International Surgical stapling instrument comprising internal passage between stapling cartridge and elongate channel
US11596406B2 (en) 2014-04-16 2023-03-07 Cilag Gmbh International Fastener cartridges including extensions having different configurations
US11944307B2 (en) 2014-04-16 2024-04-02 Cilag Gmbh International Surgical stapling system including jaw windows
US11883026B2 (en) 2014-04-16 2024-01-30 Cilag Gmbh International Fastener cartridge assemblies and staple retainer cover arrangements
US11918222B2 (en) 2014-04-16 2024-03-05 Cilag Gmbh International Stapling assembly having firing member viewing windows
US11974746B2 (en) 2014-04-16 2024-05-07 Cilag Gmbh International Anvil for use with a surgical stapling assembly
US11717294B2 (en) 2014-04-16 2023-08-08 Cilag Gmbh International End effector arrangements comprising indicators
US11517315B2 (en) 2014-04-16 2022-12-06 Cilag Gmbh International Fastener cartridges including extensions having different configurations
US11298134B2 (en) 2014-04-16 2022-04-12 Cilag Gmbh International Fastener cartridge comprising non-uniform fasteners
US11963678B2 (en) 2014-04-16 2024-04-23 Cilag Gmbh International Fastener cartridges including extensions having different configurations
US9480746B2 (en) 2014-04-21 2016-11-01 Pola Pharma Inc. Resin container filled with antifungal pharmaceutical composition
US12042147B2 (en) 2014-09-05 2024-07-23 Cllag GmbH International Smart cartridge wake up operation and data retention
US11071545B2 (en) 2014-09-05 2021-07-27 Cilag Gmbh International Smart cartridge wake up operation and data retention
US11311294B2 (en) 2014-09-05 2022-04-26 Cilag Gmbh International Powered medical device including measurement of closure state of jaws
US11076854B2 (en) 2014-09-05 2021-08-03 Cilag Gmbh International Smart cartridge wake up operation and data retention
US11653918B2 (en) 2014-09-05 2023-05-23 Cilag Gmbh International Local display of tissue parameter stabilization
US11389162B2 (en) 2014-09-05 2022-07-19 Cilag Gmbh International Smart cartridge wake up operation and data retention
US10905423B2 (en) 2014-09-05 2021-02-02 Ethicon Llc Smart cartridge wake up operation and data retention
US11406386B2 (en) 2014-09-05 2022-08-09 Cilag Gmbh International End effector including magnetic and impedance sensors
US11717297B2 (en) 2014-09-05 2023-08-08 Cilag Gmbh International Smart cartridge wake up operation and data retention
US12076017B2 (en) 2014-09-18 2024-09-03 Cilag Gmbh International Surgical instrument including a deployable knife
US11284898B2 (en) 2014-09-18 2022-03-29 Cilag Gmbh International Surgical instrument including a deployable knife
US11523821B2 (en) 2014-09-26 2022-12-13 Cilag Gmbh International Method for creating a flexible staple line
US12016564B2 (en) 2014-09-26 2024-06-25 Cilag Gmbh International Circular fastener cartridges for applying radially expandable fastener lines
US11202633B2 (en) 2014-09-26 2021-12-21 Cilag Gmbh International Surgical stapling buttresses and adjunct materials
CN107106409A (zh) * 2014-10-02 2017-08-29 泰尔茂株式会社 用于容纳蛋白质溶液制剂的医疗用容器
US10736630B2 (en) 2014-10-13 2020-08-11 Ethicon Llc Staple cartridge
US12004741B2 (en) 2014-10-16 2024-06-11 Cilag Gmbh International Staple cartridge comprising a tissue thickness compensator
US10905418B2 (en) 2014-10-16 2021-02-02 Ethicon Llc Staple cartridge comprising a tissue thickness compensator
US11701114B2 (en) 2014-10-16 2023-07-18 Cilag Gmbh International Staple cartridge
US11931031B2 (en) 2014-10-16 2024-03-19 Cilag Gmbh International Staple cartridge comprising a deck including an upper surface and a lower surface
US11185325B2 (en) 2014-10-16 2021-11-30 Cilag Gmbh International End effector including different tissue gaps
US11918210B2 (en) 2014-10-16 2024-03-05 Cilag Gmbh International Staple cartridge comprising a cartridge body including a plurality of wells
US11141153B2 (en) 2014-10-29 2021-10-12 Cilag Gmbh International Staple cartridges comprising driver arrangements
US11457918B2 (en) 2014-10-29 2022-10-04 Cilag Gmbh International Cartridge assemblies for surgical staplers
US11864760B2 (en) 2014-10-29 2024-01-09 Cilag Gmbh International Staple cartridges comprising driver arrangements
US11931038B2 (en) 2014-10-29 2024-03-19 Cilag Gmbh International Cartridge assemblies for surgical staplers
US11241229B2 (en) 2014-10-29 2022-02-08 Cilag Gmbh International Staple cartridges comprising driver arrangements
US10617417B2 (en) 2014-11-06 2020-04-14 Ethicon Llc Staple cartridge comprising a releasable adjunct material
US11337698B2 (en) 2014-11-06 2022-05-24 Cilag Gmbh International Staple cartridge comprising a releasable adjunct material
US11382628B2 (en) 2014-12-10 2022-07-12 Cilag Gmbh International Articulatable surgical instrument system
US10736636B2 (en) 2014-12-10 2020-08-11 Ethicon Llc Articulatable surgical instrument system
US10743873B2 (en) 2014-12-18 2020-08-18 Ethicon Llc Drive arrangements for articulatable surgical instruments
US10806448B2 (en) 2014-12-18 2020-10-20 Ethicon Llc Surgical instrument assembly comprising a flexible articulation system
US11083453B2 (en) 2014-12-18 2021-08-10 Cilag Gmbh International Surgical stapling system including a flexible firing actuator and lateral buckling supports
US11678877B2 (en) 2014-12-18 2023-06-20 Cilag Gmbh International Surgical instrument including a flexible support configured to support a flexible firing member
US12029419B2 (en) 2014-12-18 2024-07-09 Cilag Gmbh International Surgical instrument including a flexible support configured to support a flexible firing member
US10695058B2 (en) 2014-12-18 2020-06-30 Ethicon Llc Surgical instrument systems comprising an articulatable end effector and means for adjusting the firing stroke of a firing member
US11517311B2 (en) 2014-12-18 2022-12-06 Cilag Gmbh International Surgical instrument systems comprising an articulatable end effector and means for adjusting the firing stroke of a firing member
US11399831B2 (en) 2014-12-18 2022-08-02 Cilag Gmbh International Drive arrangements for articulatable surgical instruments
US11571207B2 (en) 2014-12-18 2023-02-07 Cilag Gmbh International Surgical system including lateral supports for a flexible drive member
US10945728B2 (en) 2014-12-18 2021-03-16 Ethicon Llc Locking arrangements for detachable shaft assemblies with articulatable surgical end effectors
US12108950B2 (en) 2014-12-18 2024-10-08 Cilag Gmbh International Surgical instrument assembly comprising a flexible articulation system
US11553911B2 (en) 2014-12-18 2023-01-17 Cilag Gmbh International Surgical instrument assembly comprising a flexible articulation system
US11547403B2 (en) 2014-12-18 2023-01-10 Cilag Gmbh International Surgical instrument having a laminate firing actuator and lateral buckling supports
US11812958B2 (en) 2014-12-18 2023-11-14 Cilag Gmbh International Locking arrangements for detachable shaft assemblies with articulatable surgical end effectors
US11547404B2 (en) 2014-12-18 2023-01-10 Cilag Gmbh International Surgical instrument assembly comprising a flexible articulation system
US12076018B2 (en) 2015-02-27 2024-09-03 Cilag Gmbh International Modular stapling assembly
US11154301B2 (en) 2015-02-27 2021-10-26 Cilag Gmbh International Modular stapling assembly
US11324506B2 (en) 2015-02-27 2022-05-10 Cilag Gmbh International Modular stapling assembly
US11744588B2 (en) 2015-02-27 2023-09-05 Cilag Gmbh International Surgical stapling instrument including a removably attachable battery pack
US11426160B2 (en) 2015-03-06 2022-08-30 Cilag Gmbh International Smart sensors with local signal processing
US10966627B2 (en) 2015-03-06 2021-04-06 Ethicon Llc Time dependent evaluation of sensor data to determine stability, creep, and viscoelastic elements of measures
US10687806B2 (en) 2015-03-06 2020-06-23 Ethicon Llc Adaptive tissue compression techniques to adjust closure rates for multiple tissue types
US10617412B2 (en) 2015-03-06 2020-04-14 Ethicon Llc System for detecting the mis-insertion of a staple cartridge into a surgical stapler
US11826132B2 (en) 2015-03-06 2023-11-28 Cilag Gmbh International Time dependent evaluation of sensor data to determine stability, creep, and viscoelastic elements of measures
US11224423B2 (en) 2015-03-06 2022-01-18 Cilag Gmbh International Smart sensors with local signal processing
US11109859B2 (en) 2015-03-06 2021-09-07 Cilag Gmbh International Surgical instrument comprising a lockable battery housing
US11350843B2 (en) 2015-03-06 2022-06-07 Cilag Gmbh International Time dependent evaluation of sensor data to determine stability, creep, and viscoelastic elements of measures
US11944338B2 (en) 2015-03-06 2024-04-02 Cilag Gmbh International Multiple level thresholds to modify operation of powered surgical instruments
US10772625B2 (en) 2015-03-06 2020-09-15 Ethicon Llc Signal and power communication system positioned on a rotatable shaft
US11918212B2 (en) 2015-03-31 2024-03-05 Cilag Gmbh International Surgical instrument with selectively disengageable drive systems
US10835249B2 (en) 2015-08-17 2020-11-17 Ethicon Llc Implantable layers for a surgical instrument
US10617418B2 (en) 2015-08-17 2020-04-14 Ethicon Llc Implantable layers for a surgical instrument
US11058425B2 (en) 2015-08-17 2021-07-13 Ethicon Llc Implantable layers for a surgical instrument
US11344299B2 (en) 2015-09-23 2022-05-31 Cilag Gmbh International Surgical stapler having downstream current-based motor control
US11026678B2 (en) 2015-09-23 2021-06-08 Cilag Gmbh International Surgical stapler having motor control based on an electrical parameter related to a motor current
US10863986B2 (en) 2015-09-23 2020-12-15 Ethicon Llc Surgical stapler having downstream current-based motor control
US11490889B2 (en) 2015-09-23 2022-11-08 Cilag Gmbh International Surgical stapler having motor control based on an electrical parameter related to a motor current
US11849946B2 (en) 2015-09-23 2023-12-26 Cilag Gmbh International Surgical stapler having downstream current-based motor control
US11076929B2 (en) 2015-09-25 2021-08-03 Cilag Gmbh International Implantable adjunct systems for determining adjunct skew
US10980539B2 (en) 2015-09-30 2021-04-20 Ethicon Llc Implantable adjunct comprising bonded layers
US10932779B2 (en) 2015-09-30 2021-03-02 Ethicon Llc Compressible adjunct with crossing spacer fibers
US11903586B2 (en) 2015-09-30 2024-02-20 Cilag Gmbh International Compressible adjunct with crossing spacer fibers
US10603039B2 (en) 2015-09-30 2020-03-31 Ethicon Llc Progressively releasable implantable adjunct for use with a surgical stapling instrument
US11793522B2 (en) 2015-09-30 2023-10-24 Cilag Gmbh International Staple cartridge assembly including a compressible adjunct
US11890015B2 (en) 2015-09-30 2024-02-06 Cilag Gmbh International Compressible adjunct with crossing spacer fibers
US11944308B2 (en) 2015-09-30 2024-04-02 Cilag Gmbh International Compressible adjunct with crossing spacer fibers
US10736633B2 (en) 2015-09-30 2020-08-11 Ethicon Llc Compressible adjunct with looping members
US11690623B2 (en) 2015-09-30 2023-07-04 Cilag Gmbh International Method for applying an implantable layer to a fastener cartridge
US11712244B2 (en) 2015-09-30 2023-08-01 Cilag Gmbh International Implantable layer with spacer fibers
US11553916B2 (en) 2015-09-30 2023-01-17 Cilag Gmbh International Compressible adjunct with crossing spacer fibers
US11083454B2 (en) 2015-12-30 2021-08-10 Cilag Gmbh International Mechanisms for compensating for drivetrain failure in powered surgical instruments
US11058422B2 (en) 2015-12-30 2021-07-13 Cilag Gmbh International Mechanisms for compensating for battery pack failure in powered surgical instruments
US11129613B2 (en) 2015-12-30 2021-09-28 Cilag Gmbh International Surgical instruments with separable motors and motor control circuits
US11759208B2 (en) 2015-12-30 2023-09-19 Cilag Gmbh International Mechanisms for compensating for battery pack failure in powered surgical instruments
US11484309B2 (en) 2015-12-30 2022-11-01 Cilag Gmbh International Surgical stapling system comprising a controller configured to cause a motor to reset a firing sequence
US11213293B2 (en) 2016-02-09 2022-01-04 Cilag Gmbh International Articulatable surgical instruments with single articulation link arrangements
US11730471B2 (en) 2016-02-09 2023-08-22 Cilag Gmbh International Articulatable surgical instruments with single articulation link arrangements
US11523823B2 (en) 2016-02-09 2022-12-13 Cilag Gmbh International Surgical instruments with non-symmetrical articulation arrangements
US11826045B2 (en) 2016-02-12 2023-11-28 Cilag Gmbh International Mechanisms for compensating for drivetrain failure in powered surgical instruments
US11224426B2 (en) 2016-02-12 2022-01-18 Cilag Gmbh International Mechanisms for compensating for drivetrain failure in powered surgical instruments
US11779336B2 (en) 2016-02-12 2023-10-10 Cilag Gmbh International Mechanisms for compensating for drivetrain failure in powered surgical instruments
US11344303B2 (en) 2016-02-12 2022-05-31 Cilag Gmbh International Mechanisms for compensating for drivetrain failure in powered surgical instruments
US10617413B2 (en) 2016-04-01 2020-04-14 Ethicon Llc Closure system arrangements for surgical cutting and stapling devices with separate and distinct firing shafts
US11179150B2 (en) 2016-04-15 2021-11-23 Cilag Gmbh International Systems and methods for controlling a surgical stapling and cutting instrument
US11317910B2 (en) 2016-04-15 2022-05-03 Cilag Gmbh International Surgical instrument with detection sensors
US11191545B2 (en) 2016-04-15 2021-12-07 Cilag Gmbh International Staple formation detection mechanisms
US11311292B2 (en) 2016-04-15 2022-04-26 Cilag Gmbh International Surgical instrument with detection sensors
US11517306B2 (en) 2016-04-15 2022-12-06 Cilag Gmbh International Surgical instrument with detection sensors
US11350932B2 (en) 2016-04-15 2022-06-07 Cilag Gmbh International Surgical instrument with improved stop/start control during a firing motion
US11931028B2 (en) 2016-04-15 2024-03-19 Cilag Gmbh International Surgical instrument with multiple program responses during a firing motion
US11026684B2 (en) 2016-04-15 2021-06-08 Ethicon Llc Surgical instrument with multiple program responses during a firing motion
US11642125B2 (en) 2016-04-15 2023-05-09 Cilag Gmbh International Robotic surgical system including a user interface and a control circuit
US11051810B2 (en) 2016-04-15 2021-07-06 Cilag Gmbh International Modular surgical instrument with configurable operating mode
US11607239B2 (en) 2016-04-15 2023-03-21 Cilag Gmbh International Systems and methods for controlling a surgical stapling and cutting instrument
US11284891B2 (en) 2016-04-15 2022-03-29 Cilag Gmbh International Surgical instrument with multiple program responses during a firing motion
US11317917B2 (en) 2016-04-18 2022-05-03 Cilag Gmbh International Surgical stapling system comprising a lockable firing assembly
US11811253B2 (en) 2016-04-18 2023-11-07 Cilag Gmbh International Surgical robotic system with fault state detection configurations based on motor current draw
US11350928B2 (en) 2016-04-18 2022-06-07 Cilag Gmbh International Surgical instrument comprising a tissue thickness lockout and speed control system
US11559303B2 (en) 2016-04-18 2023-01-24 Cilag Gmbh International Cartridge lockout arrangements for rotary powered surgical cutting and stapling instruments
US11147554B2 (en) 2016-04-18 2021-10-19 Cilag Gmbh International Surgical instrument system comprising a magnetic lockout
US11918215B2 (en) 2016-12-21 2024-03-05 Cilag Gmbh International Staple cartridge with array of staple pockets
US10758230B2 (en) 2016-12-21 2020-09-01 Ethicon Llc Surgical instrument with primary and safety processors
US12004745B2 (en) 2016-12-21 2024-06-11 Cilag Gmbh International Surgical instrument system comprising an end effector lockout and a firing assembly lockout
US12011166B2 (en) 2016-12-21 2024-06-18 Cilag Gmbh International Articulatable surgical stapling instruments
US11766259B2 (en) 2016-12-21 2023-09-26 Cilag Gmbh International Method of deforming staples from two different types of staple cartridges with the same surgical stapling instrument
US10639035B2 (en) 2016-12-21 2020-05-05 Ethicon Llc Surgical stapling instruments and replaceable tool assemblies thereof
US11766260B2 (en) 2016-12-21 2023-09-26 Cilag Gmbh International Methods of stapling tissue
US11497499B2 (en) 2016-12-21 2022-11-15 Cilag Gmbh International Articulatable surgical stapling instruments
US10667809B2 (en) 2016-12-21 2020-06-02 Ethicon Llc Staple cartridge and staple cartridge channel comprising windows defined therein
US10682138B2 (en) 2016-12-21 2020-06-16 Ethicon Llc Bilaterally asymmetric staple forming pocket pairs
US11992213B2 (en) 2016-12-21 2024-05-28 Cilag Gmbh International Surgical stapling instruments with replaceable staple cartridges
US11317913B2 (en) 2016-12-21 2022-05-03 Cilag Gmbh International Lockout arrangements for surgical end effectors and replaceable tool assemblies
US10687809B2 (en) 2016-12-21 2020-06-23 Ethicon Llc Surgical staple cartridge with movable camming member configured to disengage firing member lockout features
US10568624B2 (en) 2016-12-21 2020-02-25 Ethicon Llc Surgical instruments with jaws that are pivotable about a fixed axis and include separate and distinct closure and firing systems
US10695055B2 (en) 2016-12-21 2020-06-30 Ethicon Llc Firing assembly comprising a lockout
US11369376B2 (en) 2016-12-21 2022-06-28 Cilag Gmbh International Surgical stapling systems
US10973516B2 (en) 2016-12-21 2021-04-13 Ethicon Llc Surgical end effectors and adaptable firing members therefor
US10959727B2 (en) 2016-12-21 2021-03-30 Ethicon Llc Articulatable surgical end effector with asymmetric shaft arrangement
US11350935B2 (en) 2016-12-21 2022-06-07 Cilag Gmbh International Surgical tool assemblies with closure stroke reduction features
US11419606B2 (en) 2016-12-21 2022-08-23 Cilag Gmbh International Shaft assembly comprising a clutch configured to adapt the output of a rotary firing member to two different systems
US11191543B2 (en) 2016-12-21 2021-12-07 Cilag Gmbh International Assembly comprising a lock
US11701115B2 (en) 2016-12-21 2023-07-18 Cilag Gmbh International Methods of stapling tissue
US10905422B2 (en) 2016-12-21 2021-02-02 Ethicon Llc Surgical instrument for use with a robotic surgical system
US10736629B2 (en) 2016-12-21 2020-08-11 Ethicon Llc Surgical tool assemblies with clutching arrangements for shifting between closure systems with closure stroke reduction features and articulation and firing systems
US11957344B2 (en) 2016-12-21 2024-04-16 Cilag Gmbh International Surgical stapler having rows of obliquely oriented staples
US10898186B2 (en) 2016-12-21 2021-01-26 Ethicon Llc Staple forming pocket arrangements comprising primary sidewalls and pocket sidewalls
US11849948B2 (en) 2016-12-21 2023-12-26 Cilag Gmbh International Method for resetting a fuse of a surgical instrument shaft
US11090048B2 (en) 2016-12-21 2021-08-17 Cilag Gmbh International Method for resetting a fuse of a surgical instrument shaft
US11096689B2 (en) 2016-12-21 2021-08-24 Cilag Gmbh International Shaft assembly comprising a lockout
US10610224B2 (en) 2016-12-21 2020-04-07 Ethicon Llc Lockout arrangements for surgical end effectors and replaceable tool assemblies
US11931034B2 (en) 2016-12-21 2024-03-19 Cilag Gmbh International Surgical stapling instruments with smart staple cartridges
US10893864B2 (en) 2016-12-21 2021-01-19 Ethicon Staple cartridges and arrangements of staples and staple cavities therein
US10639034B2 (en) 2016-12-21 2020-05-05 Ethicon Llc Surgical instruments with lockout arrangements for preventing firing system actuation unless an unspent staple cartridge is present
US10588630B2 (en) 2016-12-21 2020-03-17 Ethicon Llc Surgical tool assemblies with closure stroke reduction features
US10758229B2 (en) 2016-12-21 2020-09-01 Ethicon Llc Surgical instrument comprising improved jaw control
US10888322B2 (en) 2016-12-21 2021-01-12 Ethicon Llc Surgical instrument comprising a cutting member
US11564688B2 (en) 2016-12-21 2023-01-31 Cilag Gmbh International Robotic surgical tool having a retraction mechanism
US11653917B2 (en) 2016-12-21 2023-05-23 Cilag Gmbh International Surgical stapling systems
US11134942B2 (en) 2016-12-21 2021-10-05 Cilag Gmbh International Surgical stapling instruments and staple-forming anvils
US11350934B2 (en) 2016-12-21 2022-06-07 Cilag Gmbh International Staple forming pocket arrangement to accommodate different types of staples
US10588631B2 (en) 2016-12-21 2020-03-17 Ethicon Llc Surgical instruments with positive jaw opening features
US10881401B2 (en) 2016-12-21 2021-01-05 Ethicon Llc Staple firing member comprising a missing cartridge and/or spent cartridge lockout
US11160551B2 (en) 2016-12-21 2021-11-02 Cilag Gmbh International Articulatable surgical stapling instruments
US11224428B2 (en) 2016-12-21 2022-01-18 Cilag Gmbh International Surgical stapling systems
US11571210B2 (en) 2016-12-21 2023-02-07 Cilag Gmbh International Firing assembly comprising a multiple failed-state fuse
US11160553B2 (en) 2016-12-21 2021-11-02 Cilag Gmbh International Surgical stapling systems
US10624635B2 (en) 2016-12-21 2020-04-21 Ethicon Llc Firing members with non-parallel jaw engagement features for surgical end effectors
US11191540B2 (en) 2016-12-21 2021-12-07 Cilag Gmbh International Protective cover arrangements for a joint interface between a movable jaw and actuator shaft of a surgical instrument
US11191539B2 (en) 2016-12-21 2021-12-07 Cilag Gmbh International Shaft assembly comprising a manually-operable retraction system for use with a motorized surgical instrument system
US10603036B2 (en) 2016-12-21 2020-03-31 Ethicon Llc Articulatable surgical instrument with independent pivotable linkage distal of an articulation lock
US11179155B2 (en) 2016-12-21 2021-11-23 Cilag Gmbh International Anvil arrangements for surgical staplers
US10856868B2 (en) 2016-12-21 2020-12-08 Ethicon Llc Firing member pin configurations
US10617414B2 (en) 2016-12-21 2020-04-14 Ethicon Llc Closure member arrangements for surgical instruments
US10779823B2 (en) 2016-12-21 2020-09-22 Ethicon Llc Firing member pin angle
US10954023B2 (en) 2016-12-29 2021-03-23 Tetra Laval Holdings & Finance S.A. Package for pourable food products and method for moulding a polymeric opening portion
CN110139807A (zh) * 2016-12-29 2019-08-16 利乐拉瓦尔集团及财务有限公司 用于可灌装食品的包装和用于模制聚合物开口部分的方法
US11167889B2 (en) 2017-04-13 2021-11-09 Rohto Pharmaceutical Co., Ltd. Squeeze bottle
CN110505861B (zh) * 2017-04-13 2022-06-14 乐敦制药株式会社 挤压瓶
CN110505861A (zh) * 2017-04-13 2019-11-26 乐敦制药株式会社 挤压瓶
US10624633B2 (en) 2017-06-20 2020-04-21 Ethicon Llc Systems and methods for controlling motor velocity of a surgical stapling and cutting instrument
USD890784S1 (en) 2017-06-20 2020-07-21 Ethicon Llc Display panel with changeable graphical user interface
USD879809S1 (en) 2017-06-20 2020-03-31 Ethicon Llc Display panel with changeable graphical user interface
USD879808S1 (en) 2017-06-20 2020-03-31 Ethicon Llc Display panel with graphical user interface
US11653914B2 (en) 2017-06-20 2023-05-23 Cilag Gmbh International Systems and methods for controlling motor velocity of a surgical stapling and cutting instrument according to articulation angle of end effector
US11382638B2 (en) 2017-06-20 2022-07-12 Cilag Gmbh International Closed loop feedback control of motor velocity of a surgical stapling and cutting instrument based on measured time over a specified displacement distance
US11517325B2 (en) 2017-06-20 2022-12-06 Cilag Gmbh International Closed loop feedback control of motor velocity of a surgical stapling and cutting instrument based on measured displacement distance traveled over a specified time interval
US11793513B2 (en) 2017-06-20 2023-10-24 Cilag Gmbh International Systems and methods for controlling motor speed according to user input for a surgical instrument
US10779820B2 (en) 2017-06-20 2020-09-22 Ethicon Llc Systems and methods for controlling motor speed according to user input for a surgical instrument
US10646220B2 (en) 2017-06-20 2020-05-12 Ethicon Llc Systems and methods for controlling displacement member velocity for a surgical instrument
US11672532B2 (en) 2017-06-20 2023-06-13 Cilag Gmbh International Techniques for adaptive control of motor velocity of a surgical stapling and cutting instrument
US10595882B2 (en) 2017-06-20 2020-03-24 Ethicon Llc Methods for closed loop control of motor velocity of a surgical stapling and cutting instrument
US10813639B2 (en) 2017-06-20 2020-10-27 Ethicon Llc Closed loop feedback control of motor velocity of a surgical stapling and cutting instrument based on system conditions
US11090046B2 (en) 2017-06-20 2021-08-17 Cilag Gmbh International Systems and methods for controlling displacement member motion of a surgical stapling and cutting instrument
US10980537B2 (en) 2017-06-20 2021-04-20 Ethicon Llc Closed loop feedback control of motor velocity of a surgical stapling and cutting instrument based on measured time over a specified number of shaft rotations
US10888321B2 (en) 2017-06-20 2021-01-12 Ethicon Llc Systems and methods for controlling velocity of a displacement member of a surgical stapling and cutting instrument
US11071554B2 (en) 2017-06-20 2021-07-27 Cilag Gmbh International Closed loop feedback control of motor velocity of a surgical stapling and cutting instrument based on magnitude of velocity error measurements
US10881399B2 (en) 2017-06-20 2021-01-05 Ethicon Llc Techniques for adaptive control of motor velocity of a surgical stapling and cutting instrument
US10881396B2 (en) 2017-06-20 2021-01-05 Ethicon Llc Surgical instrument with variable duration trigger arrangement
USD1039559S1 (en) 2017-06-20 2024-08-20 Cilag Gmbh International Display panel with changeable graphical user interface
US11871939B2 (en) 2017-06-20 2024-01-16 Cilag Gmbh International Method for closed loop control of motor velocity of a surgical stapling and cutting instrument
US11141154B2 (en) 2017-06-27 2021-10-12 Cilag Gmbh International Surgical end effectors and anvils
US11266405B2 (en) 2017-06-27 2022-03-08 Cilag Gmbh International Surgical anvil manufacturing methods
US11324503B2 (en) 2017-06-27 2022-05-10 Cilag Gmbh International Surgical firing member arrangements
US10772629B2 (en) 2017-06-27 2020-09-15 Ethicon Llc Surgical anvil arrangements
US11090049B2 (en) 2017-06-27 2021-08-17 Cilag Gmbh International Staple forming pocket arrangements
US10856869B2 (en) 2017-06-27 2020-12-08 Ethicon Llc Surgical anvil arrangements
US10631859B2 (en) 2017-06-27 2020-04-28 Ethicon Llc Articulation systems for surgical instruments
US10993716B2 (en) 2017-06-27 2021-05-04 Ethicon Llc Surgical anvil arrangements
US11766258B2 (en) 2017-06-27 2023-09-26 Cilag Gmbh International Surgical anvil arrangements
US11678880B2 (en) 2017-06-28 2023-06-20 Cilag Gmbh International Surgical instrument comprising a shaft including a housing arrangement
US10779824B2 (en) 2017-06-28 2020-09-22 Ethicon Llc Surgical instrument comprising an articulation system lockable by a closure system
US11246592B2 (en) 2017-06-28 2022-02-15 Cilag Gmbh International Surgical instrument comprising an articulation system lockable to a frame
US10786253B2 (en) 2017-06-28 2020-09-29 Ethicon Llc Surgical end effectors with improved jaw aperture arrangements
US11020114B2 (en) 2017-06-28 2021-06-01 Cilag Gmbh International Surgical instruments with articulatable end effector with axially shortened articulation joint configurations
US10758232B2 (en) 2017-06-28 2020-09-01 Ethicon Llc Surgical instrument with positive jaw opening features
US11389161B2 (en) 2017-06-28 2022-07-19 Cilag Gmbh International Surgical instrument comprising selectively actuatable rotatable couplers
US11000279B2 (en) 2017-06-28 2021-05-11 Ethicon Llc Surgical instrument comprising an articulation system ratio
US10695057B2 (en) 2017-06-28 2020-06-30 Ethicon Llc Surgical instrument lockout arrangement
US10903685B2 (en) 2017-06-28 2021-01-26 Ethicon Llc Surgical shaft assemblies with slip ring assemblies forming capacitive channels
US11564686B2 (en) 2017-06-28 2023-01-31 Cilag Gmbh International Surgical shaft assemblies with flexible interfaces
USD906355S1 (en) 2017-06-28 2020-12-29 Ethicon Llc Display screen or portion thereof with a graphical user interface for a surgical instrument
US11058424B2 (en) 2017-06-28 2021-07-13 Cilag Gmbh International Surgical instrument comprising an offset articulation joint
US11529140B2 (en) 2017-06-28 2022-12-20 Cilag Gmbh International Surgical instrument lockout arrangement
USD1018577S1 (en) 2017-06-28 2024-03-19 Cilag Gmbh International Display screen or portion thereof with a graphical user interface for a surgical instrument
US11642128B2 (en) 2017-06-28 2023-05-09 Cilag Gmbh International Method for articulating a surgical instrument
US11083455B2 (en) 2017-06-28 2021-08-10 Cilag Gmbh International Surgical instrument comprising an articulation system ratio
US10588633B2 (en) 2017-06-28 2020-03-17 Ethicon Llc Surgical instruments with open and closable jaws and axially movable firing member that is initially parked in close proximity to the jaws prior to firing
US11696759B2 (en) 2017-06-28 2023-07-11 Cilag Gmbh International Surgical stapling instruments comprising shortened staple cartridge noses
US10765427B2 (en) 2017-06-28 2020-09-08 Ethicon Llc Method for articulating a surgical instrument
US10716614B2 (en) 2017-06-28 2020-07-21 Ethicon Llc Surgical shaft assemblies with slip ring assemblies with increased contact pressure
US11259805B2 (en) 2017-06-28 2022-03-01 Cilag Gmbh International Surgical instrument comprising firing member supports
US11826048B2 (en) 2017-06-28 2023-11-28 Cilag Gmbh International Surgical instrument comprising selectively actuatable rotatable couplers
US11478242B2 (en) 2017-06-28 2022-10-25 Cilag Gmbh International Jaw retainer arrangement for retaining a pivotable surgical instrument jaw in pivotable retaining engagement with a second surgical instrument jaw
US11484310B2 (en) 2017-06-28 2022-11-01 Cilag Gmbh International Surgical instrument comprising a shaft including a closure tube profile
US11007022B2 (en) 2017-06-29 2021-05-18 Ethicon Llc Closed loop velocity control techniques based on sensed tissue parameters for robotic surgical instrument
US11890005B2 (en) 2017-06-29 2024-02-06 Cilag Gmbh International Methods for closed loop velocity control for robotic surgical instrument
US10898183B2 (en) 2017-06-29 2021-01-26 Ethicon Llc Robotic surgical instrument with closed loop feedback techniques for advancement of closure member during firing
US10932772B2 (en) 2017-06-29 2021-03-02 Ethicon Llc Methods for closed loop velocity control for robotic surgical instrument
US11304695B2 (en) 2017-08-03 2022-04-19 Cilag Gmbh International Surgical system shaft interconnection
US11471155B2 (en) 2017-08-03 2022-10-18 Cilag Gmbh International Surgical system bailout
US11944300B2 (en) 2017-08-03 2024-04-02 Cilag Gmbh International Method for operating a surgical system bailout
US11974742B2 (en) 2017-08-03 2024-05-07 Cilag Gmbh International Surgical system comprising an articulation bailout
USD907647S1 (en) 2017-09-29 2021-01-12 Ethicon Llc Display screen or portion thereof with animated graphical user interface
US10743872B2 (en) 2017-09-29 2020-08-18 Ethicon Llc System and methods for controlling a display of a surgical instrument
US10765429B2 (en) 2017-09-29 2020-09-08 Ethicon Llc Systems and methods for providing alerts according to the operational state of a surgical instrument
US11399829B2 (en) 2017-09-29 2022-08-02 Cilag Gmbh International Systems and methods of initiating a power shutdown mode for a surgical instrument
USD917500S1 (en) 2017-09-29 2021-04-27 Ethicon Llc Display screen or portion thereof with graphical user interface
US11998199B2 (en) 2017-09-29 2024-06-04 Cllag GmbH International System and methods for controlling a display of a surgical instrument
USD907648S1 (en) 2017-09-29 2021-01-12 Ethicon Llc Display screen or portion thereof with animated graphical user interface
US11090075B2 (en) 2017-10-30 2021-08-17 Cilag Gmbh International Articulation features for surgical end effector
US11134944B2 (en) 2017-10-30 2021-10-05 Cilag Gmbh International Surgical stapler knife motion controls
US12076011B2 (en) 2017-10-30 2024-09-03 Cilag Gmbh International Surgical stapler knife motion controls
US11478244B2 (en) 2017-10-31 2022-10-25 Cilag Gmbh International Cartridge body design with force reduction based on firing completion
US10842490B2 (en) 2017-10-31 2020-11-24 Ethicon Llc Cartridge body design with force reduction based on firing completion
US10779903B2 (en) 2017-10-31 2020-09-22 Ethicon Llc Positive shaft rotation lock activated by jaw closure
US11963680B2 (en) 2017-10-31 2024-04-23 Cilag Gmbh International Cartridge body design with force reduction based on firing completion
US11197670B2 (en) 2017-12-15 2021-12-14 Cilag Gmbh International Surgical end effectors with pivotal jaws configured to touch at their respective distal ends when fully closed
US11006955B2 (en) 2017-12-15 2021-05-18 Ethicon Llc End effectors with positive jaw opening features for use with adapters for electromechanical surgical instruments
US11071543B2 (en) 2017-12-15 2021-07-27 Cilag Gmbh International Surgical end effectors with clamping assemblies configured to increase jaw aperture ranges
US10966718B2 (en) 2017-12-15 2021-04-06 Ethicon Llc Dynamic clamping assemblies with improved wear characteristics for use in connection with electromechanical surgical instruments
US10869666B2 (en) 2017-12-15 2020-12-22 Ethicon Llc Adapters with control systems for controlling multiple motors of an electromechanical surgical instrument
US11896222B2 (en) 2017-12-15 2024-02-13 Cilag Gmbh International Methods of operating surgical end effectors
US10828033B2 (en) 2017-12-15 2020-11-10 Ethicon Llc Handheld electromechanical surgical instruments with improved motor control arrangements for positioning components of an adapter coupled thereto
US10779826B2 (en) 2017-12-15 2020-09-22 Ethicon Llc Methods of operating surgical end effectors
US10779825B2 (en) 2017-12-15 2020-09-22 Ethicon Llc Adapters with end effector position sensing and control arrangements for use in connection with electromechanical surgical instruments
US10743875B2 (en) 2017-12-15 2020-08-18 Ethicon Llc Surgical end effectors with jaw stiffener arrangements configured to permit monitoring of firing member
US10687813B2 (en) 2017-12-15 2020-06-23 Ethicon Llc Adapters with firing stroke sensing arrangements for use in connection with electromechanical surgical instruments
US11033267B2 (en) 2017-12-15 2021-06-15 Ethicon Llc Systems and methods of controlling a clamping member firing rate of a surgical instrument
US10743874B2 (en) 2017-12-15 2020-08-18 Ethicon Llc Sealed adapters for use with electromechanical surgical instruments
US12076096B2 (en) 2017-12-19 2024-09-03 Cilag Gmbh International Method for determining the position of a rotatable jaw of a surgical instrument attachment assembly
US11284953B2 (en) 2017-12-19 2022-03-29 Cilag Gmbh International Method for determining the position of a rotatable jaw of a surgical instrument attachment assembly
US10729509B2 (en) 2017-12-19 2020-08-04 Ethicon Llc Surgical instrument comprising closure and firing locking mechanism
US11045270B2 (en) 2017-12-19 2021-06-29 Cilag Gmbh International Robotic attachment comprising exterior drive actuator
US10716565B2 (en) 2017-12-19 2020-07-21 Ethicon Llc Surgical instruments with dual articulation drivers
US11020112B2 (en) 2017-12-19 2021-06-01 Ethicon Llc Surgical tools configured for interchangeable use with different controller interfaces
USD910847S1 (en) 2017-12-19 2021-02-16 Ethicon Llc Surgical instrument assembly
US10835330B2 (en) 2017-12-19 2020-11-17 Ethicon Llc Method for determining the position of a rotatable jaw of a surgical instrument attachment assembly
US11129680B2 (en) 2017-12-21 2021-09-28 Cilag Gmbh International Surgical instrument comprising a projector
US11364027B2 (en) 2017-12-21 2022-06-21 Cilag Gmbh International Surgical instrument comprising speed control
US11076853B2 (en) 2017-12-21 2021-08-03 Cilag Gmbh International Systems and methods of displaying a knife position during transection for a surgical instrument
US11311290B2 (en) 2017-12-21 2022-04-26 Cilag Gmbh International Surgical instrument comprising an end effector dampener
US11179151B2 (en) 2017-12-21 2021-11-23 Cilag Gmbh International Surgical instrument comprising a display
US10743868B2 (en) 2017-12-21 2020-08-18 Ethicon Llc Surgical instrument comprising a pivotable distal head
US10682134B2 (en) 2017-12-21 2020-06-16 Ethicon Llc Continuous use self-propelled stapling instrument
US11576668B2 (en) 2017-12-21 2023-02-14 Cilag Gmbh International Staple instrument comprising a firing path display
US11179152B2 (en) 2017-12-21 2021-11-23 Cilag Gmbh International Surgical instrument comprising a tissue grasping system
US11369368B2 (en) 2017-12-21 2022-06-28 Cilag Gmbh International Surgical instrument comprising synchronized drive systems
US11883019B2 (en) 2017-12-21 2024-01-30 Cilag Gmbh International Stapling instrument comprising a staple feeding system
US11751867B2 (en) 2017-12-21 2023-09-12 Cilag Gmbh International Surgical instrument comprising sequenced systems
US11337691B2 (en) 2017-12-21 2022-05-24 Cilag Gmbh International Surgical instrument configured to determine firing path
US11583274B2 (en) 2017-12-21 2023-02-21 Cilag Gmbh International Self-guiding stapling instrument
US11849939B2 (en) 2017-12-21 2023-12-26 Cilag Gmbh International Continuous use self-propelled stapling instrument
CN108785077A (zh) * 2018-05-31 2018-11-13 湖北科伦药业有限公司 一种利巴韦林安瓿瓶及其生产工艺
US11207065B2 (en) 2018-08-20 2021-12-28 Cilag Gmbh International Method for fabricating surgical stapler anvils
US10856870B2 (en) 2018-08-20 2020-12-08 Ethicon Llc Switching arrangements for motor powered articulatable surgical instruments
US10779821B2 (en) 2018-08-20 2020-09-22 Ethicon Llc Surgical stapler anvils with tissue stop features configured to avoid tissue pinch
US11045192B2 (en) 2018-08-20 2021-06-29 Cilag Gmbh International Fabricating techniques for surgical stapler anvils
US12076008B2 (en) 2018-08-20 2024-09-03 Cilag Gmbh International Method for operating a powered articulatable surgical instrument
US11957339B2 (en) 2018-08-20 2024-04-16 Cilag Gmbh International Method for fabricating surgical stapler anvils
US11253256B2 (en) 2018-08-20 2022-02-22 Cilag Gmbh International Articulatable motor powered surgical instruments with dedicated articulation motor arrangements
US10842492B2 (en) 2018-08-20 2020-11-24 Ethicon Llc Powered articulatable surgical instruments with clutching and locking arrangements for linking an articulation drive system to a firing drive system
US11324501B2 (en) 2018-08-20 2022-05-10 Cilag Gmbh International Surgical stapling devices with improved closure members
USD914878S1 (en) 2018-08-20 2021-03-30 Ethicon Llc Surgical instrument anvil
US11083458B2 (en) 2018-08-20 2021-08-10 Cilag Gmbh International Powered surgical instruments with clutching arrangements to convert linear drive motions to rotary drive motions
US10912559B2 (en) 2018-08-20 2021-02-09 Ethicon Llc Reinforced deformable anvil tip for surgical stapler anvil
US11039834B2 (en) 2018-08-20 2021-06-22 Cilag Gmbh International Surgical stapler anvils with staple directing protrusions and tissue stability features
US11291440B2 (en) 2018-08-20 2022-04-05 Cilag Gmbh International Method for operating a powered articulatable surgical instrument
CN113302133A (zh) * 2018-12-07 2021-08-24 藤森工业株式会社 滴眼剂容器
US11147553B2 (en) 2019-03-25 2021-10-19 Cilag Gmbh International Firing drive arrangements for surgical systems
US11172929B2 (en) 2019-03-25 2021-11-16 Cilag Gmbh International Articulation drive arrangements for surgical systems
US11147551B2 (en) 2019-03-25 2021-10-19 Cilag Gmbh International Firing drive arrangements for surgical systems
US11696761B2 (en) 2019-03-25 2023-07-11 Cilag Gmbh International Firing drive arrangements for surgical systems
US11452528B2 (en) 2019-04-30 2022-09-27 Cilag Gmbh International Articulation actuators for a surgical instrument
US11648009B2 (en) 2019-04-30 2023-05-16 Cilag Gmbh International Rotatable jaw tip for a surgical instrument
US11253254B2 (en) 2019-04-30 2022-02-22 Cilag Gmbh International Shaft rotation actuator on a surgical instrument
US11903581B2 (en) 2019-04-30 2024-02-20 Cilag Gmbh International Methods for stapling tissue using a surgical instrument
US11426251B2 (en) 2019-04-30 2022-08-30 Cilag Gmbh International Articulation directional lights on a surgical instrument
US11432816B2 (en) 2019-04-30 2022-09-06 Cilag Gmbh International Articulation pin for a surgical instrument
US11471157B2 (en) 2019-04-30 2022-10-18 Cilag Gmbh International Articulation control mapping for a surgical instrument
US11553919B2 (en) 2019-06-28 2023-01-17 Cilag Gmbh International Method for authenticating the compatibility of a staple cartridge with a surgical instrument
US11350938B2 (en) 2019-06-28 2022-06-07 Cilag Gmbh International Surgical instrument comprising an aligned rfid sensor
US11497492B2 (en) 2019-06-28 2022-11-15 Cilag Gmbh International Surgical instrument including an articulation lock
US12004740B2 (en) 2019-06-28 2024-06-11 Cilag Gmbh International Surgical stapling system having an information decryption protocol
US11478241B2 (en) 2019-06-28 2022-10-25 Cilag Gmbh International Staple cartridge including projections
US11684434B2 (en) 2019-06-28 2023-06-27 Cilag Gmbh International Surgical RFID assemblies for instrument operational setting control
US11229437B2 (en) 2019-06-28 2022-01-25 Cilag Gmbh International Method for authenticating the compatibility of a staple cartridge with a surgical instrument
US11219455B2 (en) 2019-06-28 2022-01-11 Cilag Gmbh International Surgical instrument including a lockout key
US11298132B2 (en) 2019-06-28 2022-04-12 Cilag GmbH Inlernational Staple cartridge including a honeycomb extension
US11298127B2 (en) 2019-06-28 2022-04-12 Cilag GmbH Interational Surgical stapling system having a lockout mechanism for an incompatible cartridge
US11638587B2 (en) 2019-06-28 2023-05-02 Cilag Gmbh International RFID identification systems for surgical instruments
US11684369B2 (en) 2019-06-28 2023-06-27 Cilag Gmbh International Method of using multiple RFID chips with a surgical assembly
US11376098B2 (en) 2019-06-28 2022-07-05 Cilag Gmbh International Surgical instrument system comprising an RFID system
US11771419B2 (en) 2019-06-28 2023-10-03 Cilag Gmbh International Packaging for a replaceable component of a surgical stapling system
US11399837B2 (en) 2019-06-28 2022-08-02 Cilag Gmbh International Mechanisms for motor control adjustments of a motorized surgical instrument
US11627959B2 (en) 2019-06-28 2023-04-18 Cilag Gmbh International Surgical instruments including manual and powered system lockouts
US11291451B2 (en) 2019-06-28 2022-04-05 Cilag Gmbh International Surgical instrument with battery compatibility verification functionality
US11523822B2 (en) 2019-06-28 2022-12-13 Cilag Gmbh International Battery pack including a circuit interrupter
US11660163B2 (en) 2019-06-28 2023-05-30 Cilag Gmbh International Surgical system with RFID tags for updating motor assembly parameters
US11051807B2 (en) 2019-06-28 2021-07-06 Cilag Gmbh International Packaging assembly including a particulate trap
US11426167B2 (en) 2019-06-28 2022-08-30 Cilag Gmbh International Mechanisms for proper anvil attachment surgical stapling head assembly
US11241235B2 (en) 2019-06-28 2022-02-08 Cilag Gmbh International Method of using multiple RFID chips with a surgical assembly
US11246678B2 (en) 2019-06-28 2022-02-15 Cilag Gmbh International Surgical stapling system having a frangible RFID tag
US11224497B2 (en) 2019-06-28 2022-01-18 Cilag Gmbh International Surgical systems with multiple RFID tags
US11259803B2 (en) 2019-06-28 2022-03-01 Cilag Gmbh International Surgical stapling system having an information encryption protocol
US11744593B2 (en) 2019-06-28 2023-09-05 Cilag Gmbh International Method for authenticating the compatibility of a staple cartridge with a surgical instrument
US11464601B2 (en) 2019-06-28 2022-10-11 Cilag Gmbh International Surgical instrument comprising an RFID system for tracking a movable component
US11553971B2 (en) 2019-06-28 2023-01-17 Cilag Gmbh International Surgical RFID assemblies for display and communication
US11234698B2 (en) 2019-12-19 2022-02-01 Cilag Gmbh International Stapling system comprising a clamp lockout and a firing lockout
US11291447B2 (en) 2019-12-19 2022-04-05 Cilag Gmbh International Stapling instrument comprising independent jaw closing and staple firing systems
US11911032B2 (en) 2019-12-19 2024-02-27 Cilag Gmbh International Staple cartridge comprising a seating cam
US11529139B2 (en) 2019-12-19 2022-12-20 Cilag Gmbh International Motor driven surgical instrument
US11464512B2 (en) 2019-12-19 2022-10-11 Cilag Gmbh International Staple cartridge comprising a curved deck surface
US11607219B2 (en) 2019-12-19 2023-03-21 Cilag Gmbh International Staple cartridge comprising a detachable tissue cutting knife
US12035913B2 (en) 2019-12-19 2024-07-16 Cilag Gmbh International Staple cartridge comprising a deployable knife
US11529137B2 (en) 2019-12-19 2022-12-20 Cilag Gmbh International Staple cartridge comprising driver retention members
US11559304B2 (en) 2019-12-19 2023-01-24 Cilag Gmbh International Surgical instrument comprising a rapid closure mechanism
US11701111B2 (en) 2019-12-19 2023-07-18 Cilag Gmbh International Method for operating a surgical stapling instrument
US11844520B2 (en) 2019-12-19 2023-12-19 Cilag Gmbh International Staple cartridge comprising driver retention members
US11931033B2 (en) 2019-12-19 2024-03-19 Cilag Gmbh International Staple cartridge comprising a latch lockout
US11446029B2 (en) 2019-12-19 2022-09-20 Cilag Gmbh International Staple cartridge comprising projections extending from a curved deck surface
US11304696B2 (en) 2019-12-19 2022-04-19 Cilag Gmbh International Surgical instrument comprising a powered articulation system
US11576672B2 (en) 2019-12-19 2023-02-14 Cilag Gmbh International Surgical instrument comprising a closure system including a closure member and an opening member driven by a drive screw
US11504122B2 (en) 2019-12-19 2022-11-22 Cilag Gmbh International Surgical instrument comprising a nested firing member
USD975851S1 (en) 2020-06-02 2023-01-17 Cilag Gmbh International Staple cartridge
USD974560S1 (en) 2020-06-02 2023-01-03 Cilag Gmbh International Staple cartridge
USD967421S1 (en) 2020-06-02 2022-10-18 Cilag Gmbh International Staple cartridge
USD975278S1 (en) 2020-06-02 2023-01-10 Cilag Gmbh International Staple cartridge
USD975850S1 (en) 2020-06-02 2023-01-17 Cilag Gmbh International Staple cartridge
USD966512S1 (en) 2020-06-02 2022-10-11 Cilag Gmbh International Staple cartridge
USD976401S1 (en) 2020-06-02 2023-01-24 Cilag Gmbh International Staple cartridge
US12064107B2 (en) 2020-07-28 2024-08-20 Cilag Gmbh International Articulatable surgical instruments with articulation joints comprising flexible exoskeleton arrangements
US11737748B2 (en) 2020-07-28 2023-08-29 Cilag Gmbh International Surgical instruments with double spherical articulation joints with pivotable links
US11974741B2 (en) 2020-07-28 2024-05-07 Cilag Gmbh International Surgical instruments with differential articulation joint arrangements for accommodating flexible actuators
US11871925B2 (en) 2020-07-28 2024-01-16 Cilag Gmbh International Surgical instruments with dual spherical articulation joint arrangements
US11864756B2 (en) 2020-07-28 2024-01-09 Cilag Gmbh International Surgical instruments with flexible ball chain drive arrangements
US11638582B2 (en) 2020-07-28 2023-05-02 Cilag Gmbh International Surgical instruments with torsion spine drive arrangements
US11857182B2 (en) 2020-07-28 2024-01-02 Cilag Gmbh International Surgical instruments with combination function articulation joint arrangements
US11883024B2 (en) 2020-07-28 2024-01-30 Cilag Gmbh International Method of operating a surgical instrument
US11660090B2 (en) 2020-07-28 2023-05-30 Cllag GmbH International Surgical instruments with segmented flexible drive arrangements
US11826013B2 (en) 2020-07-28 2023-11-28 Cilag Gmbh International Surgical instruments with firing member closure features
US11452526B2 (en) 2020-10-29 2022-09-27 Cilag Gmbh International Surgical instrument comprising a staged voltage regulation start-up system
US11896217B2 (en) 2020-10-29 2024-02-13 Cilag Gmbh International Surgical instrument comprising an articulation lock
US11717289B2 (en) 2020-10-29 2023-08-08 Cilag Gmbh International Surgical instrument comprising an indicator which indicates that an articulation drive is actuatable
US11517390B2 (en) 2020-10-29 2022-12-06 Cilag Gmbh International Surgical instrument comprising a limited travel switch
US12076194B2 (en) 2020-10-29 2024-09-03 Cilag Gmbh International Surgical instrument comprising an articulation indicator
US11617577B2 (en) 2020-10-29 2023-04-04 Cilag Gmbh International Surgical instrument comprising a sensor configured to sense whether an articulation drive of the surgical instrument is actuatable
US12029421B2 (en) 2020-10-29 2024-07-09 Cilag Gmbh International Surgical instrument comprising a staged voltage regulation start-up system
US11844518B2 (en) 2020-10-29 2023-12-19 Cilag Gmbh International Method for operating a surgical instrument
US11779330B2 (en) 2020-10-29 2023-10-10 Cilag Gmbh International Surgical instrument comprising a jaw alignment system
USD980425S1 (en) 2020-10-29 2023-03-07 Cilag Gmbh International Surgical instrument assembly
USD1013170S1 (en) 2020-10-29 2024-01-30 Cilag Gmbh International Surgical instrument assembly
US11931025B2 (en) 2020-10-29 2024-03-19 Cilag Gmbh International Surgical instrument comprising a releasable closure drive lock
US12053175B2 (en) 2020-10-29 2024-08-06 Cilag Gmbh International Surgical instrument comprising a stowed closure actuator stop
US11534259B2 (en) 2020-10-29 2022-12-27 Cilag Gmbh International Surgical instrument comprising an articulation indicator
US11678882B2 (en) 2020-12-02 2023-06-20 Cilag Gmbh International Surgical instruments with interactive features to remedy incidental sled movements
US11653915B2 (en) 2020-12-02 2023-05-23 Cilag Gmbh International Surgical instruments with sled location detection and adjustment features
US11744581B2 (en) 2020-12-02 2023-09-05 Cilag Gmbh International Powered surgical instruments with multi-phase tissue treatment
US11849943B2 (en) 2020-12-02 2023-12-26 Cilag Gmbh International Surgical instrument with cartridge release mechanisms
US11653920B2 (en) 2020-12-02 2023-05-23 Cilag Gmbh International Powered surgical instruments with communication interfaces through sterile barrier
US12016559B2 (en) 2020-12-02 2024-06-25 Cllag GmbH International Powered surgical instruments with communication interfaces through sterile barrier
US11944296B2 (en) 2020-12-02 2024-04-02 Cilag Gmbh International Powered surgical instruments with external connectors
US11737751B2 (en) 2020-12-02 2023-08-29 Cilag Gmbh International Devices and methods of managing energy dissipated within sterile barriers of surgical instrument housings
US11890010B2 (en) 2020-12-02 2024-02-06 Cllag GmbH International Dual-sided reinforced reload for surgical instruments
US11627960B2 (en) 2020-12-02 2023-04-18 Cilag Gmbh International Powered surgical instruments with smart reload with separately attachable exteriorly mounted wiring connections
US12035911B2 (en) 2021-02-26 2024-07-16 Cilag Gmbh International Stapling instrument comprising a separate power antenna and a data transfer antenna
US11925349B2 (en) 2021-02-26 2024-03-12 Cilag Gmbh International Adjustment to transfer parameters to improve available power
US12108951B2 (en) 2021-02-26 2024-10-08 Cilag Gmbh International Staple cartridge comprising a sensing array and a temperature control system
US11751869B2 (en) 2021-02-26 2023-09-12 Cilag Gmbh International Monitoring of multiple sensors over time to detect moving characteristics of tissue
US11980362B2 (en) 2021-02-26 2024-05-14 Cilag Gmbh International Surgical instrument system comprising a power transfer coil
US11701113B2 (en) 2021-02-26 2023-07-18 Cilag Gmbh International Stapling instrument comprising a separate power antenna and a data transfer antenna
US11696757B2 (en) 2021-02-26 2023-07-11 Cilag Gmbh International Monitoring of internal systems to detect and track cartridge motion status
US11723657B2 (en) 2021-02-26 2023-08-15 Cilag Gmbh International Adjustable communication based on available bandwidth and power capacity
US11793514B2 (en) 2021-02-26 2023-10-24 Cilag Gmbh International Staple cartridge comprising sensor array which may be embedded in cartridge body
US11749877B2 (en) 2021-02-26 2023-09-05 Cilag Gmbh International Stapling instrument comprising a signal antenna
US11730473B2 (en) 2021-02-26 2023-08-22 Cilag Gmbh International Monitoring of manufacturing life-cycle
US12035912B2 (en) 2021-02-26 2024-07-16 Cilag Gmbh International Adjustable communication based on available bandwidth and power capacity
US12035910B2 (en) 2021-02-26 2024-07-16 Cllag GmbH International Monitoring of internal systems to detect and track cartridge motion status
US11950777B2 (en) 2021-02-26 2024-04-09 Cilag Gmbh International Staple cartridge comprising an information access control system
US11950779B2 (en) 2021-02-26 2024-04-09 Cilag Gmbh International Method of powering and communicating with a staple cartridge
US11744583B2 (en) 2021-02-26 2023-09-05 Cilag Gmbh International Distal communication array to tune frequency of RF systems
US11812964B2 (en) 2021-02-26 2023-11-14 Cilag Gmbh International Staple cartridge comprising a power management circuit
US12042146B2 (en) 2021-03-22 2024-07-23 Cilag Gmbh International Surgical stapling instrument comprising a retraction system
US11723658B2 (en) 2021-03-22 2023-08-15 Cilag Gmbh International Staple cartridge comprising a firing lockout
US11826012B2 (en) 2021-03-22 2023-11-28 Cilag Gmbh International Stapling instrument comprising a pulsed motor-driven firing rack
US11826042B2 (en) 2021-03-22 2023-11-28 Cilag Gmbh International Surgical instrument comprising a firing drive including a selectable leverage mechanism
US12023026B2 (en) 2021-03-22 2024-07-02 Cilag Gmbh International Staple cartridge comprising a firing lockout
US11717291B2 (en) 2021-03-22 2023-08-08 Cilag Gmbh International Staple cartridge comprising staples configured to apply different tissue compression
US11759202B2 (en) 2021-03-22 2023-09-19 Cilag Gmbh International Staple cartridge comprising an implantable layer
US11806011B2 (en) 2021-03-22 2023-11-07 Cilag Gmbh International Stapling instrument comprising tissue compression systems
US11737749B2 (en) 2021-03-22 2023-08-29 Cilag Gmbh International Surgical stapling instrument comprising a retraction system
US11744603B2 (en) 2021-03-24 2023-09-05 Cilag Gmbh International Multi-axis pivot joints for surgical instruments and methods for manufacturing same
US11896219B2 (en) 2021-03-24 2024-02-13 Cilag Gmbh International Mating features between drivers and underside of a cartridge deck
US11793516B2 (en) 2021-03-24 2023-10-24 Cilag Gmbh International Surgical staple cartridge comprising longitudinal support beam
US12102323B2 (en) 2021-03-24 2024-10-01 Cilag Gmbh International Rotary-driven surgical stapling assembly comprising a floatable component
US11896218B2 (en) 2021-03-24 2024-02-13 Cilag Gmbh International Method of using a powered stapling device
US11857183B2 (en) 2021-03-24 2024-01-02 Cilag Gmbh International Stapling assembly components having metal substrates and plastic bodies
US11849944B2 (en) 2021-03-24 2023-12-26 Cilag Gmbh International Drivers for fastener cartridge assemblies having rotary drive screws
US11903582B2 (en) 2021-03-24 2024-02-20 Cilag Gmbh International Leveraging surfaces for cartridge installation
US11832816B2 (en) 2021-03-24 2023-12-05 Cilag Gmbh International Surgical stapling assembly comprising nonplanar staples and planar staples
US11786243B2 (en) 2021-03-24 2023-10-17 Cilag Gmbh International Firing members having flexible portions for adapting to a load during a surgical firing stroke
US11786239B2 (en) 2021-03-24 2023-10-17 Cilag Gmbh International Surgical instrument articulation joint arrangements comprising multiple moving linkage features
US11944336B2 (en) 2021-03-24 2024-04-02 Cilag Gmbh International Joint arrangements for multi-planar alignment and support of operational drive shafts in articulatable surgical instruments
US11849945B2 (en) 2021-03-24 2023-12-26 Cilag Gmbh International Rotary-driven surgical stapling assembly comprising eccentrically driven firing member
US11918217B2 (en) 2021-05-28 2024-03-05 Cilag Gmbh International Stapling instrument comprising a staple cartridge insertion stop
US11723662B2 (en) 2021-05-28 2023-08-15 Cilag Gmbh International Stapling instrument comprising an articulation control display
US11826047B2 (en) 2021-05-28 2023-11-28 Cilag Gmbh International Stapling instrument comprising jaw mounts
US11998201B2 (en) 2021-05-28 2024-06-04 Cilag CmbH International Stapling instrument comprising a firing lockout
US11877745B2 (en) 2021-10-18 2024-01-23 Cilag Gmbh International Surgical stapling assembly having longitudinally-repeating staple leg clusters
US11957337B2 (en) 2021-10-18 2024-04-16 Cilag Gmbh International Surgical stapling assembly with offset ramped drive surfaces
US11980363B2 (en) 2021-10-18 2024-05-14 Cilag Gmbh International Row-to-row staple array variations
US12089841B2 (en) 2021-10-28 2024-09-17 Cilag CmbH International Staple cartridge identification systems
US11937816B2 (en) 2021-10-28 2024-03-26 Cilag Gmbh International Electrical lead arrangements for surgical instruments
US12114859B2 (en) 2022-05-26 2024-10-15 Cilag Gmbh International Articulatable surgical instrument system

Also Published As

Publication number Publication date
CN100515381C (zh) 2009-07-22

Similar Documents

Publication Publication Date Title
CN1777406A (zh) 填充了药液的塑料安瓶及其制造方法
CN1210341C (zh) 用于制造单层和多层膜的耐高压加热的非粘合的可热封的聚合物共混物
CN1081536C (zh) 多层薄膜
CN1089680C (zh) 多层层压制品及其用途
CN1262250C (zh) 气体防渗性高的贮器和密封盖组合件
EP1616549B1 (en) Drug solution filling plastic ampoule and process for producing the same
CN1676119A (zh) 灌输溶液袋以及用于其的层压薄膜
CN1270687C (zh) 适合与柔性容器配合使用的进料入口管
JP5492905B2 (ja) 酸素吸収機能を有するプラスチックフィルム及び輸液バッグ
CN1195454C (zh) 具有可选择增大的隔室的柔性医疗容器及其制造方法
CN1049861C (zh) 树脂层压板及其容器
CN1976669A (zh) 带有改进的可脱开密封部的医用容器
CN1745019A (zh) 具有可热封帽的药剂瓶以及灌装该药剂瓶的设备和方法
CN1128005A (zh) 防污染密封膜及其制品
EP3312006A1 (en) Multi-layered plastic polymeric container for the storage of pharmaceutical compositions
CN1320073A (zh) 由单中心催化剂制成的聚合物的改进结构
CN1976668A (zh) 用于制备医用混合溶液的柔性多腔室容器
KR20160013067A (ko) 광선 차단 시트 및 용기
CN1276832C (zh) 尤其用于包装液体药用产品的可高压灭菌的,无pvc的多层膜,生产方法和用途
CN110121419A (zh) 层叠体、泡罩容器、泡罩包装及层叠体的制造方法
CN1589216A (zh) 液体食品用的纸包装材料和制造纸包装材料的方法
JP7460679B2 (ja) 薬液収容プラスチック容器
CN1077026C (zh) 改进了机械性能的多层热可收缩薄膜
CN1484581A (zh) 层压材料和容器
CN1761444A (zh) 医用容器

Legal Events

Date Code Title Description
C06 Publication
PB01 Publication
C10 Entry into substantive examination
SE01 Entry into force of request for substantive examination
C14 Grant of patent or utility model
GR01 Patent grant
CF01 Termination of patent right due to non-payment of annual fee

Granted publication date: 20090722

CF01 Termination of patent right due to non-payment of annual fee