CN1768818A - Externally applied plaster for treating Bi syndrome and preparation method thereof - Google Patents
Externally applied plaster for treating Bi syndrome and preparation method thereof Download PDFInfo
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- CN1768818A CN1768818A CNA2005101043202A CN200510104320A CN1768818A CN 1768818 A CN1768818 A CN 1768818A CN A2005101043202 A CNA2005101043202 A CN A2005101043202A CN 200510104320 A CN200510104320 A CN 200510104320A CN 1768818 A CN1768818 A CN 1768818A
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Abstract
The invention relates to an external plaster for treating rheumatism and process for preparation, wherein the components of the raw material include Cinnamomum cassia, white mustard seed, dragon's blood resin, musk, frankincense, myrrh, boneol and red pellet.
Description
Technical field
The present invention relates to medicine, relate to a kind of externally applied ointment that utilizes herbal raw material to make that is applicable to diseases such as cervical spondylosis, intervertebral disc prolapse, osteoarthritis, ankylosing spondylitis more specifically, the invention still further relates to the preparation method of this externally applied ointment.
Background technology
Textual research: " wet three gas of wind and cold are assorted to be numbness to closing " of " the Huang di's Canon of Medicine element is asked the numbness opinion ", " doctor weighing apparatus arthromyodynia analyse little " says: " numbness person closes also; skin and flesh muscles and bones is dyed for the wind and cold dampness is assorted, vascular occlusion does not circulate yet " all spells out the diagnosis and treatment main points of arthromyodynia.Say to strange many stasis of bloods of disease opinion of Wang Qingren, all disease excessive phlegm of Zhu Danxi, enriched arthromyodynia diagnosis and treatment thinking.
Arthralgia one disease belongs to Chinese medicine arthromyodynia category, since establishing " wet three gas of wind and cold are assorted extremely; close and be numbness " basic pathogenesis from " the Huang di's Canon of Medicine element is asked the numbness opinion " and dispeling the wind, win wet, cold expelling fundamentum, back physicians from a family for generations family constantly develops to some extent, as " doctor family must read " advocate migratory arthralgia ginseng with enrich blood, the arthralgia aggravated by cold ginseng to be mending fire, the damp arthralgia ginseng is with invigorating the spleen and replenishing QI etc.The external treatment aspect, " Ling Shu Miraculous Pivot or Divine Axis muscles along the regular meridians " introduction is made the horse patch with Chinese liquor and osmanthus and is controlled, and Prescriptions Worth Thousand Gold for Emergencies pastes method called after " plaster applying a plaster for therapeutic purpose " with plaster, points out " method of treatment by oral administration of medicines, the i.e. method of external treatment to " Li Yue Pianwen, Rhymed Discourse for Topical Remedies "; The reason of treatment by oral administration of medicines, the i.e. reason of external treatment ", and enriched the route of administration of treatment arthromyodynia, form through sick the clinical thinking of drug effect.Controlling the numbness method to contemporary external becomes the conventional measure that tcm clinical practice can not be incomplete, little with its convenient drug administration, toxic and side effects, do not disturb advantage such as gastrointestinal function, firmly gets patient and his family's welcome.
But when traditional black plaster prepares, medical material and oil high temperature heating simultaneously, the Chinese medicine loss of effective components is more, and makes this technology be eliminated substantially.Modern novel externally used paste then takes effective component extracting to coat the method that rubber is mounted lining material central authorities as converging strange neck waist subsides, Qizheng Tibetan Medicine etc., improves the relative concentration of active ingredient, but remains the shortcoming in action time short (12～24 hours).
Summary of the invention
One of purpose of the present invention provides a kind of drug effect height, the externally applied ointment that is used for the treatment of the numbness disease that has no side effect; The technology that two of purpose provides this externally applied ointment is simple, can reduce the preparation method of destroying and losing active constituents of medicine.
One of purpose of the present invention can realize by following technical measures:
This externally applied ointment is the unguentum of being made by the herbal raw material of following weight parts proportioning:
Spina Gleditsiae 1～10 Radix Astragali 1～8 Radix Angelicae Sinensis 1～8
Rhizoma Chuanxiong 1～8 Radix Aconiti 1～6 Radix Aconiti Kusnezoffii 1～6
Ramulus Cinnamomi 1～6 Herba Ephedrae 1～6 Scorpio 1～4
Arisaema Cum Bile 1～12 Scolopendra 1～4 Rhizoma Cibotii 1～8
Radix Dipsaci 1～8 Sanguis Draxonis 1～4 Zaocys 1～4
Semen Sinapis Albae 1～10 Moschus 1～4 Cortex Cinnamomi 1～8
Borneolum Syntheticum 1～4 Olibanum 1～4 Myrrha 1～4
Radix Clematidis 1～8 Radix Angelicae Dahuricae 1～8 Herba speranskiae tuberculatae 1～10
Herba Lycopodii 1～10.
Spina Gleditsiae: this product is the dry Spina jujubae of leguminous plant Fructus Gleditsia Gleditsia siniensis Lam.
The Radix Astragali: this product is the dry root of leguminous plant Radix Astagali Astragalus membranaceus (Fisch.) Bge.var.mongholicus (Bge.) Heiao or Radix Astragali Astragalus membranaceus (Fisch) Bge..
Radix Dipsaci: this product is the dry root of Radix Dipsaci plant Radix Dipsaci Dipsacus asperoides C.Y.Cheng et T.M.Ai.
Rhizoma Chuanxiong: this product is the dry rhizome of samphire Rhizoma Chuanxiong Ligusticum chuanxiong Hort..
Radix Angelicae Sinensis: this product is the dry root of umbelliferae angelica Angelica sinensis (Oliv) Diels.
Sanguis Draxonis: this product is babassu Sanguis Draxonis Daemonorops draco BL.
Cortex Cinnamomi: this product is the dry bark of canella Cortex Cinnamomi Cinnamomum cassia Presl.
Radix Aconiti: this product is the dried root of ranunculaceae plant Aconitum carmichjaelii Debx. Aconitum carmichaeli Debx..
Radix Aconiti Kusnezoffii: this product is the dried root of ranunculaceae plant Aconitum kusnezoffii Reichb Aconitum kusnezoffii Reichb..
Herba Ephedrae: this product is the dry herb stem branch of Ephedraceae plant plait Herba Ephedrae Ephedra sinica Stapf, epheday intermedia EphedraintermediaSchrenk et C.A.Mer. or ephedra equisetina Ephedra equisetina Bge..
Scorpio: this product is the dry body of Buthidae animal Scorpio Buthus martensii Karsch.
Scolopendra: this product is the dry body of Scolopendridae animal Scolopendpa Subspinipes Mutilans L. KOCH Scolopendra subspinipes mutilans L.Koch.
Rhizoma Cibotii: be Dicksoniaceae herbaceos perennial Rhizoma Cibotii Cibotium.., (L.) the dry root stock of j.Sm..
Zaocys: this product is the dry body of Colubridae animal Zaocys Zaocys dhumnades (Cantor).Semen Sinapis: this product is the dry mature fruit of crucifer Caulis et Folium Sinapis albee Sinapis alba L..
Moschus: this product is the secretions in the ripe male abdominal part sachet of the former Moschus moschiferous Moschus of animal in deer family moschiferusLinnaeus, woods Moschus moschiferous Moschusberezovskii Flerov or horse Moschus moschiferous Moschus sifanicus Przewalskii.
Borneolum Syntheticum: be to be that raw material is processed synthetic Borneolum Syntheticum with Oleum Terebinthinae, Camphora etc.
Arisaema Cum Bile: this product is the dry tuber of aroid Rhizoma Arisaematis Arisaema erubescens (Wall), Arisaema heterophyllum B1. Arisaema heterophyllum Blume or arisaema amurense Maxim Arisaema amurense Maxim.
Herbal raw material Spina Gleditsiae of the present invention contains flavonoid glycoside, and the Radix Astragali contains astragaloside, and Radix Aconiti, Radix Aconiti Kusnezoffii contain alkaloid, and Sanguis Draxonis contains dracorhodin, and Moschus contains volatile muscone, and Cortex Cinnamomi contains volatile oil, Borneolum Syntheticum contains Borneolum Syntheticum etc.Replenishing qi and promoting blood flows such as the Radix Astragali, Radix Angelicae Sinensis, Rhizoma Chuanxiong, Sanguis Draxonis in the side, with the agent of temperature three-way meridians such as Radix Clematidis, Spina Gleditsiae, Herba Ephedrae, Ramulus Cinnamomi, Cortex Cinnamomi, Herba speranskiae tuberculatae, Herba Lycopodii mutually 5, can effectively improve regional flow's perfusion, correct the tissue ischemia anaerobic condition, promote rebuliding of local metabolic mechanism; The agent of the stasis of blood clearly of eliminating the phlegm such as Olibanum, Myrrha, Rhizoma Arisaematis, Semen Sinapis Albae, Scorpio, Scolopendra, the Radix Angelicae Dahuricae, can remove the pathological state that the local expectorant stasis of blood is handed over resistance, promptly remove pathological metabolism product and pro-inflammatory cytokine, the high sticking and tissue degeneratiaon's edema of antagonism blood reaches the purpose that interrupts the pathology link; The agent of invigorating the liver and kidney such as Rhizoma Cibotii, Radix Dipsaci, Zaocys, bone and muscle strengthening, modern study confirm that the cell regeneration of promotion, tissue repair effect are arranged; Moschus, Borneolum Syntheticum can play " transdermal agent " sample effect with its effect of " having one's ideas straightened out ", promote medicine that the percutaneous disperse of explosive component is arranged, and the skin irritant effect that alleviates medicine is also arranged.All medicines share extending from the interior to the exterior, treating both the principal and secondary aspects of a disease, and play expelling wind and cold, promoting blood circulation to remove obstruction in the collateral, light hard eliminating stagnation, strengthening the tendons and bones, and inclined to one side cold-dampness type arthralgia one disease is had better curative effect.
Get Radix Aconiti, the flat heat of Radix Aconiti Kusnezoffii, dispelling cold by warming the meridian leads to activating collaterals to relieve pain, for controlling joint arthralgia aggravated by cold key medicine.It is inside and outside cold that Radix Aconiti removes the exterior and the interior, 5 Radixs Astragali, Radix Angelicae Sinensis, Rhizoma Cibotii, Radix Dipsaci, Rhizoma Chuanxiong are inspired healthy energy, Arisaema Cum Bile, the Semen Sinapis Albae outer expectorant of flesh side film of dispelling, Scolopendra, Scorpio, Zaocys etc. are searched the stasis of blood of staying that the thing that picks is dredged channels, Spina Gleditsiae, Ramulus Cinnamomi, Herba Ephedrae, Moschus, Borneolum Syntheticum etc. are sensible to be closed, loosing the interspaces of skin and muscles, wind dispelling go out, priming is gone into, it is logical to play evil person's blood stasis dispelling person altogether, pain spontaneous recovery and the multiple effect of function.Modern medicine grinds and confirms that most medical materials have antiinflammatory, analgesic activity preferably, and the part medical material has good local anesthesia effect, the purpose that can reach and interrupt the pathologic reflex arc, starts local repair mechanism.
The present invention is with herbal raw material modern abstraction technique effective component extracting of process and superfine communication technique, with concentrate pulverizing medicinal materials to 300～320um, the medicamental pulverata that then this is contained active component be coated with after directly merging with the ointment substrate of " releasing fire-toxin " plaster, thereby overcome above shortcoming, the advantage of traditional black plaster is developed, the destruction of high temperature to the medicine active ingredient, empirical tests administration safety, determined curative effect have been avoided simultaneously again.
Externally applied ointment of the present invention is applicable to intervertebral disc protrusion of cervical vertebra disease, osteoarthritis, ankylosing spondylitis etc.Using method is identical with common plaster, subsides in 7 days, and every subsides 15 grams, 10 subsides are a course of treatment.The individual patient part erubescence occurs, itches, and symptom is died away after the drug withdrawal.
Two of purpose of the present invention can realize by following technical measures:
According to the ormal weight of each component in the above-mentioned raw materials prescription, a, Cortex Cinnamomi, Semen Sinapis Albae, Sanguis Draxonis, Moschus, Olibanum, Myrrha, Borneolum Syntheticum powder are broken into the micropowder of 300～320um, standby; B, all the other herbal raw materials added soak with ethanol, heating extraction, filtration, merging filtrate, recovery ethanol, filtrate routinely be condensed into clear paste, again drying, be ground into the micropowder of 300～320um, standby; C, first routine are measured flavoring essence and are heated to 300～340 ℃, temper to dripping into pearl, and then amount add Plumbum preparatium routinely, stir evenly and receive cream and be soaked in releasing fire-toxin in the water; D, the ointment of C operation is heated to fusing, again a, b operation fine powder is added mixing, share on cloth, finished product.
Preparation method technology of the present invention is simple, both can carry out large-scale industrial production, also can prepare in the hospital preparation chamber.
Case is selected:
This organizes 200 examples, is tried fine horse 100 examples, matched group 100 examples.Case source: inpatient's 50 examples, outpatient's 150 examples, sex: be subjected to examination to organize male 34 examples, women 66 examples; Matched group man 34 examples, women 66 examples; Men and women's ratio is 1: 1.941.Age: maximum 65 years old, minimum 45 years old, be subjected to examination to organize average 56.43 years old, matched group 55.87 years old.The position: right knee joint 126 examples, left knee joint 74 examples, the course of disease: be subjected to examination group the shortest January, the longest 14.1, average 5.8 years; Matched group the shortest January, the longest 13.4, average 5.6 years.Severity extent is subjected to examination to organize slight 12 examples, moderate 53 examples, severe 35 examples, 12 examples that matched group is slight, moderate 54 examples, severe 34 examples.The diagnostic criteria of X-ray film according to the stage division of Kellgren, is subjected to examination group I level 14 examples, II level 18 examples, III level 44 examples, IV level 24 examples.Matched group I level 14 examples, II level 16 examples, III level 44 examples, IV level 26 examples.Generally no explicitly difference (P＞0.05) is analysed in credit by statistics, illustrates that two groups of data have comparability before treatment.
Test method:
Be subjected to the examination group external application compound recipe cream of invigorating blood circulation, every plaster pasted 3 days, and 28 days is a course of treatment.Matched group external application TIANHE GUTONG TIE cream is produced by Tianhe Pharmacy Industry Co., Ltd., Gulin, and the accurate word Z10980134 of traditional Chinese medicines during the medication, all stops all oral medicine, medicine for external use and other Therapeutic Method.
Curative effect judging standard:
Criterion of therapeutical effect in " the new Chinese medicine clinical research guideline " issued with reference to Ministry of Public Health is judged.Clinic control: sings and symptoms complete obiteration, treatment back total mark 0-2 branch.Produce effects: sings and symptoms disappears substantially, and treatment back total mark reduces 2/3.Effectively: sings and symptoms obviously improves, and treatment back total mark reduces 1/3.Invalid: sings and symptoms does not have obvious improvement, and treatment back total mark reduces less than 1/3.
Statistics: enumeration data is checked with X2, and ranked data are analyzed with Ridit.
Table 1, two groups of total effectses are analyzed
| Group | n | Clinic control | Produce effects | Effectively | Invalid | Obvious effective rate % | Total effective rate % |
| Be subjected to examination group matched group | 100 100 | 13 6 | 41 17 | 37 59 | 9 18 | 54 23 | 91 82 |
Be subjected to compare after examination group and the treatment of control group, analyze through ridir, μ=3.39, P＜0.01, there were significant differences, and the more rate that shows that is subjected to the examination group is described, and total effective rate is better than matched group.
The experimental studies results of relevant pharmacodynamics aspect shows that the mice auricle swelling that externally applied ointment 3.0g/kg xylol of the present invention causes has the obvious suppression effect, and the caused mice pain of mice thermostimulation is had significant analgesia role; 10.0g/kg, the rat paw edema that causes of 5.0g/kg on Carrageenan has the obvious suppression effect.
The influence of xylol induced mice auricle edema:
Get 50 of body weight 27-30g male mices, be divided at random compound recipe invigorate blood circulation cream big (3.0g/kg), in (1.5g/kg), little (0.75g/kg) dosage group, positive control ZHENGQINGFENGTONGNING PIAN (100mg/kg) group and blank group.Compound recipe invigorated blood circulation its deliquescing is done into about 9mm, 4.5mm, the large and small flakelet that does not wait of 2.25mm by each group dosage be affixed on two sides before and after the mouse right ear, positive control is irritated stomach 0.5ml/20g administration, and matched group gives the equal-volume distilled water and smears two sides, mouse right ear front and back.Removed the compound recipe cream of invigorating blood circulation after the administration in 2 hours, 30ul dimethylbenzene is applied to the mouse right ear exterior feature before and after the two sides cause inflammation, left auricle is in contrast.Cause scorching back 30 minutes mice is put to death, take off left and right auricle with diameter 9mm card punch at identical position, weigh, calculating left and right auricle weight difference is its swelling degree.
The influence (n=10) of table 2, xylol induced mice auricle edema
| Group | Dosage (g/kg) | Left and right sides auricle weight difference (mg, X ± SD) | The P value |
| The matched group compound recipe cream compound recipe cream compound recipe cream ZHENGQINGFENGTONGNING PIAN of invigorating blood circulation of invigorating blood circulation of invigorating blood circulation | --- 3.0 1.5 0.75 100mg | 25.85±4.26 21.10±5.16 22.10±5.49 25.50±4.32 19.00±3.79 | --- ＜0.05 ＞0.05 ＞0.05 ＜0.01 |
The result shows, the compound recipe heavy dose of group of the cream mice auricle swelling degree of invigorating blood circulation obviously subtracts (P＜0.05), and middle dosage group mice auricle swelling degree alleviates to some extent, but not statistically significant.Show that this medicine has certain antiinflammatory action.
The influence of rat paw edema due to the on Carrageenan:
Get 50 of the healthy male rats of 200-220g, be divided into 5 groups at random, be respectively compound recipe invigorate blood circulation cream big (10.0g/kg), in (5.0g/kg), little (2.5g/kg) dosage group, positive control ZHENGQINGFENGTONGNING PIAN (50mg/kg) group and blank group.Compound recipe invigorated blood circulation its deliquescing is done into about 15mm, 7.5mm, the large and small flakelet that does not wait of 3.75mm by each group dosage be affixed on the right sufficient sole of the foot upper and lower surface of rat, positive control is irritated stomach 1ml/100g administration, and matched group gives the equal-volume distilled water and smears the right sufficient sole of the foot upper and lower surface of rat.Removed the compound recipe cream of invigorating blood circulation after the administration in 2 hours, inject 1% carrageenin 0.1ml down by the right back sufficient plantar aponeurosis of each group Mus and cause inflammation, respectively with YLS-7A toes volumetric measurement instrument measure cause scorching before and cause scorching back 1., 2., 3., hour sufficient volume, calculate cause scorching before and after sufficient volume difference as the swelling degree.
The influence of rat paw edema due to table 3, the on Carrageenan (n=10, X ± SD)
| Group | Dosage (g/kg) | Cause scorching back different time swelling degree (ml) | ||
| 1h | 2h | 3h | ||
| The matched group compound recipe cream compound recipe cream compound recipe cream ZHENGQINGFENGTONGNING PIAN of invigorating blood circulation of invigorating blood circulation of invigorating blood circulation | -- 10.0 5.0 2.5 50mg | 0.151±0.14 0.158±0.20 0.174±0.18 0.189±0.22 0.143±0.20 | 0.944±0.25 0.662±0.31 * 0.703±0.25 * 0.763±0.38 0.65±0.34 * | 0.89±0.20 0.710±0.26 0.737±0.21 0.80±0.29 0.64±0.28 * |
*Compare with matched group P＜0.05
The result shows that the compound recipe cream of invigorating blood circulation has obvious inhibitory action (P＜0.05) to big or middle dosage group rat causing the foot swelling that scorching back 1 hour inner opposite angle fork dish glue causes.
Result of the test shows, the mice auricle swelling that externally applied ointment 3.0g/kg xylol of the present invention causes has the obvious suppression effect, hot plate induced mice toes pain was had significant analgesia role in 2 hours, the rat paw edema due to 10.0g/kg, the 5.0g/kg on Carrageenan has tangible antiinflammatory action.
Externally applied ointment single of the present invention is smeared administration rabbit intact skin and damaged skin is all had no stimulation.Repeatedly smearing administration (1.0g/ time, continuous 1 week) all has no stimulation to rabbit intact skin and damaged skin.
The specific embodiment:
Embodiment 1:
A, 2 kilograms of Cortex Cinnamomis, 8 kilograms of Semen Sinapis Albaes, 2 kilograms of Sanguis Draxonis, 3 kilograms of Moschus, 1 kilogram of Olibanum, 4 kilograms of Myrrhas, 1 kilogram of Borneolum Syntheticum powder are broken into the micropowder of 300～320um, standby;
B, with 3 kilograms of Spina Gleditsiaes, 8 kilograms of Radixs Astragali, 2 kilograms of Radix Angelicae Sinensis, 7 kilograms of Rhizoma Chuanxiongs, 2 kilograms of Radix Aconitis, 6 kilograms of Radix Aconiti Kusnezoffii, 2 kilograms of Ramulus Cinnamomi, 5 kilograms of Herba Ephedraes, 2 kilograms of Scorpios, 10 kilograms of Arisaema Cum Bile, 1 kilogram of Scolopendra, 8 kilograms of Rhizoma Cibotii, 2 kilograms of Radix Dipsacis, 4 kilograms of Zaocyss, 2 kilograms of Radix Clematidis, 7 kilograms of Radixs Angelicae Dahuricae, 2 kilograms of Herba speranskiae tuberculataes, 10 kilograms of Herba Lycopodiis add in 600 kilograms 70% ethanol and soaked 24 hours, heating extraction three times, each 2 hours, filter, merging filtrate, reclaim ethanol, filtrate is concentrated into the clear paste that relative density is 1.35 (55 ℃), drying again, be ground into the micropowder of 320um, standby;
C, get 10 kilograms of flavoring essences earlier and be heated to 300 ℃, temper to dripping into pearl, and then amount adds 7 kilograms of Plumbum preparatium routinely, stirs evenly receipts cream, and cream is soaked in releasing fire-toxin in the water;
D, the ointment of C operation is heated to 60 ℃ of fusings, again a, b operation fine powder is added mixing, share on cloth by every subsides 15 grams, finished product.
Embodiment 2:
A, 7 kilograms of Cortex Cinnamomis, 2 kilograms of Semen Sinapis Albaes, 4 kilograms of Sanguis Draxonis, 1 kilogram of Moschus, 3 kilograms of Olibanums, 1 kilogram of Myrrha, 3 kilograms of Borneolum Syntheticum powder are broken into the micropowder of 300～320um, standby;
B, with 8 kilograms of Spina Gleditsiaes, 2 kilograms of Radixs Astragali, 8 kilograms of Radix Angelicae Sinensis, 2 kilograms of Rhizoma Chuanxiongs, 5 kilograms of Radix Aconitis, 1 kilogram of Radix Aconiti Kusnezoffii, 5 kilograms of Ramulus Cinnamomi, 2 kilograms of Herba Ephedraes, 3 kilograms of Scorpios, 2 kilograms of Arisaema Cum Bile, 4 kilograms of Scolopendras, 2 kilograms of Rhizoma Cibotii, 7 kilograms of Radix Dipsacis, 2 kilograms of Zaocyss, 7 kilograms of Radix Clematidis, 2 kilograms of Radixs Angelicae Dahuricae, 9 kilograms of Herba speranskiae tuberculataes, 10 kilograms of Herba Lycopodiis add in 650 kilograms 70% ethanol and soaked 12 hours, heating extraction three times, each 2 hours, filter, merging filtrate, reclaim ethanol, filtrate is concentrated into the clear paste that relative density is 1.40 (55 ℃), drying again, be ground into the micropowder of 300um, standby;
C, get 10 kilograms of flavoring essences earlier and be heated to 340 ℃, temper to dripping into pearl, and then amount adds 6 kilograms of Plumbum preparatium routinely, stirs evenly receipts cream, and cream is soaked in releasing fire-toxin in the water;
D, the ointment of C operation is heated to 70 ℃ of fusings, again a, b operation fine powder is added mixing, share on cloth by every subsides 15 grams, finished product.
Embodiment 3:
A, 5 kilograms of Cortex Cinnamomis, 5 kilograms of Semen Sinapis Albaes, 2 kilograms of Sanguis Draxonis, 2 kilograms of Moschus, 2 kilograms of Olibanums, 2 kilograms of Myrrhas, 2 kilograms of Borneolum Syntheticum powder are broken into the micropowder of 300～320um, standby;
B, with 5 kilograms of Spina Gleditsiaes, 5 kilograms of Radixs Astragali, 5 kilograms of Radix Angelicae Sinensis, 5 kilograms of Rhizoma Chuanxiongs, 3 kilograms of Radix Aconitis, 3 kilograms of Radix Aconiti Kusnezoffii, 3 kilograms of Ramulus Cinnamomi, 4 kilograms of Herba Ephedraes, 2 kilograms of Scorpios, 6 kilograms of Arisaema Cum Bile, 2 kilograms of Scolopendras, 4 kilograms of Rhizoma Cibotii, 4 kilograms of Radix Dipsacis, 2 kilograms of Zaocyss, 4 kilograms of Radix Clematidis, 4 kilograms of Radixs Angelicae Dahuricae, 5 kilograms of Herba speranskiae tuberculataes, 5 kilograms of Herba Lycopodiis add in 560 kilograms 70% ethanol and soaked 18 hours, heating extraction three times, each 2 hours, filter, merging filtrate, reclaim ethanol, filtrate is concentrated into the clear paste that relative density is 1.38 (55 ℃), drying again, be ground into the micropowder of 310um, standby;
C, get 8 kilograms of flavoring essences earlier and be heated to 300 ℃, temper to dripping into pearl, and then amount adds 5 kilograms of Plumbum preparatium routinely, stirs evenly receipts cream, and cream is soaked in releasing fire-toxin in the water;
D, the ointment of C operation is heated to 65 ℃ of fusings, again a, b operation fine powder is added mixing, share on cloth by every subsides 15 grams, finished product.
Claims (2)
1, a kind of externally applied ointment that is used for the treatment of the numbness disease is characterized in that it is the unguentum of being made by the herbal raw material of following weight parts proportioning:
Spina Gleditsiae 1～10 Radix Astragali 1～8 Radix Angelicae Sinensis 1～8
Rhizoma Chuanxiong 1～8 Radix Aconiti 1～6 Radix Aconiti Kusnezoffii 1～6
Ramulus Cinnamomi 1～6 Herba Ephedrae 1～6 Scorpio 1～4
Arisaema Cum Bile 1～12 Scolopendra 1～4 Rhizoma Cibotii 1～8
Radix Dipsaci 1～8 Sanguis Draxonis 1～4 Zaocys 1～4
Semen Sinapis Albae 1～10 Moschus 1～4 Cortex Cinnamomi 1～8
Borneolum Syntheticum 1～4 Olibanum 1～4 Myrrha 1～4
Radix Clematidis 1～8 Radix Angelicae Dahuricae 1～8 Herba speranskiae tuberculatae 1～10
Herba Lycopodii 1～10.
2, a kind of preparation method that is used for the treatment of the externally applied ointment of numbness disease is characterized in that: according to the ormal weight of each component in the claim 1,
A, Cortex Cinnamomi, Semen Sinapis Albae, Sanguis Draxonis, Moschus, Olibanum, Myrrha, Borneolum Syntheticum powder are broken into the micropowder of 300～320um, standby;
B, all the other herbal raw materials added soak with ethanol, heating extraction, filtration, merging filtrate, recovery ethanol, filtrate routinely be condensed into clear paste, again drying, be ground into the micropowder of 300～320um, standby;
C, first routine are measured flavoring essence and are heated to 300～340 ℃, temper to dripping into pearl, and then amount add Plumbum preparatium routinely, stir evenly and receive cream and be soaked in releasing fire-toxin in the water;
D, the ointment of C operation is heated to fusing, again a, b operation fine powder is added mixing, share on cloth, finished product.
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| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CNB2005101043202A CN1323699C (en) | 2005-10-20 | 2005-10-20 | Externally applied plaster for treating Bi syndrome and preparation method thereof |
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| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CNB2005101043202A CN1323699C (en) | 2005-10-20 | 2005-10-20 | Externally applied plaster for treating Bi syndrome and preparation method thereof |
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| CN1768818A true CN1768818A (en) | 2006-05-10 |
| CN1323699C CN1323699C (en) | 2007-07-04 |
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| CN101152456B (en) * | 2006-09-27 | 2010-05-12 | 王克俭 | Medicine for treating hyperosteogeny, rheumatic arthritis and prolapse of intervertebral disc |
| CN101313944B (en) * | 2008-06-13 | 2011-04-27 | 刘双欧 | Herbal pain penetrating fluid |
| CN103845557A (en) * | 2012-12-07 | 2014-06-11 | 张朝军 | Radix dipsaci bone-setting powder and preparation method thereof |
| CN104189745A (en) * | 2014-08-17 | 2014-12-10 | 史玉君 | Externally applied medicine for treating osteoarthrosis |
| CN108355093A (en) * | 2018-05-23 | 2018-08-03 | 孙万民 | It is a kind of to treat the tetanic medicinal powder and preparation method thereof of waist |
| CN108853301A (en) * | 2018-09-21 | 2018-11-23 | 郭强 | A kind of Chinese medicine powder and preparation method thereof for superintending and directing moxibustion |
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|---|---|---|---|---|
| CN1175449A (en) * | 1997-07-14 | 1998-03-11 | 迟经惠 | Plaster for lumbar and cervical vertebra diseases |
| CN1299754C (en) * | 2004-02-06 | 2007-02-14 | 王德元 | Medicinal composition for treating theumalism and rheumatism diseases |
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2005
- 2005-10-20 CN CNB2005101043202A patent/CN1323699C/en not_active Expired - Fee Related
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| CN101152456B (en) * | 2006-09-27 | 2010-05-12 | 王克俭 | Medicine for treating hyperosteogeny, rheumatic arthritis and prolapse of intervertebral disc |
| CN101313944B (en) * | 2008-06-13 | 2011-04-27 | 刘双欧 | Herbal pain penetrating fluid |
| CN103845557A (en) * | 2012-12-07 | 2014-06-11 | 张朝军 | Radix dipsaci bone-setting powder and preparation method thereof |
| CN104189745A (en) * | 2014-08-17 | 2014-12-10 | 史玉君 | Externally applied medicine for treating osteoarthrosis |
| CN108355093A (en) * | 2018-05-23 | 2018-08-03 | 孙万民 | It is a kind of to treat the tetanic medicinal powder and preparation method thereof of waist |
| CN108853301A (en) * | 2018-09-21 | 2018-11-23 | 郭强 | A kind of Chinese medicine powder and preparation method thereof for superintending and directing moxibustion |
| CN110201115A (en) * | 2019-07-19 | 2019-09-06 | 韦添天 | A kind of preparation method of the Chinese medicine composition for treating stupid numbness and bone joint pain, ostalgia plaster and ostalgia plaster |
| CN110201115B (en) * | 2019-07-19 | 2021-09-21 | 韦添天 | Traditional Chinese medicine composition for treating stubborn arthralgia and osteoarticular pain, ostealgia paste and preparation method of ostealgia paste |
| CN115645503A (en) * | 2022-01-27 | 2023-01-31 | 山东中医药大学附属医院 | A pharmaceutical composition and acupoint application paste for treating chronic pain diseases |
| CN115645503B (en) * | 2022-01-27 | 2023-10-13 | 山东中医药大学附属医院 | Medicinal composition and acupoint application paste for treating chronic pain diseases |
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