CN101433665A - Medicament for treating femoral head necrosis and preparation method thereof - Google Patents
Medicament for treating femoral head necrosis and preparation method thereof Download PDFInfo
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- CN101433665A CN101433665A CNA2008102387386A CN200810238738A CN101433665A CN 101433665 A CN101433665 A CN 101433665A CN A2008102387386 A CNA2008102387386 A CN A2008102387386A CN 200810238738 A CN200810238738 A CN 200810238738A CN 101433665 A CN101433665 A CN 101433665A
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Abstract
The invention provides a medicine for treating femoral head necrosis and a method for preparing the same. The medicine is a pill preparation prepared from the following Chinese herbal medicine raw materials in weight portion ratio: epimeddium, deerhorn glue, achyranthes root, large-leaf gentian root, honeysuckle, lilyturf root, red peony root, root of red salvia, poria, naze, capsule of weeping forsythia, earthworm, dried body of scorpion, centipede, buck grass, angelica, dandehon herb, notopterygium root, angelica root, root of Taiwan angelica, rhizome of Sichuan lovage, bark of eucommia, dried rehmannia root, medlar, rhizoma drynariae, aucklandia root, root of mongolian milkvetch, root of pseudo-ginseng, dried body of ground beetle, daemonorops draco, olibanum, myrrh, raw keel, bark of amur corktree, fresh oyster shell, leatherleaf milletia, fried cucumber seed, batryticated silkworm, calcined pyrite, herb of sieblod wildginger, radix aconiti preparata, kusnezoff monkshood, caulis tinosporae, liquorice, prepared rhizoma arisaematis, herb of glabrous sarcandra, yam rhizome, dried leech and prepared nux vomica.
Description
Technical field:
The present invention relates to Chinese herbal medicine, relate in particular to a kind of medicine for the treatment of femur head necrosis; The invention still further relates to the preparation method of this medicine.
Background technology:
Ischemic necrosis of femoral head is the orthopaedics difficult and complicated illness, often by wound, drink, hormone etc. causes, as untimely treatment, will be and carry out sexual development, finally causes the forfeiture of patient's hip joint function and disables, and directly influences patient's quality of life.Clinical treatment lacks specific medicament at present, the expectant treatment loser, and last result has only operating substitution, and this will be for the patient brings bigger stress and financial burden, so urgent clinical needs medicine efficient, low toxicity addresses this problem.
Summary of the invention:
One of purpose of the present invention provides a kind of medicine that adopts effective treatment femur head necrosis that Chinese herbal medicine makes; Two of purpose provides the preparation method of this medicine.
One of purpose of the present invention can realize by following technical measures:
The medicine of treatment femur head necrosis of the present invention is the pill of being made by the herbal raw material of following weight parts proportioning:
Herba Epimedii 1-12 Colla cornus cervi 1-12 Radix Achyranthis Bidentatae 1-10 Radix Gentianae Macrophyllae 1-12
Flos Lonicerae 1-12 1-12 Radix Ophiopogonis Radix Paeoniae Rubra 1-12 Radix Salviae Miltiorrhizae 1-12
Poria 1-12 Squama Manis 1-10 Fructus Forsythiae 1-12 Pheretima 1-10
Scorpio 1-10 Scolopendra 1-10 Herba Lycopodii 1-12 Radix Angelicae Sinensis 1-10
Herba Taraxaci 1-12 Rhizoma Et Radix Notopterygii 1-12 Radix Angelicae Pubescentis 1-12 Radix Angelicae Dahuricae 1-10
Rhizoma Chuanxiong 1-8 Cortex Eucommiae 1-10 Radix Rehmanniae 1-10 Fructus Lycii 1-12
Rhizoma Drynariae 1-10 Radix Aucklandiae 1-10 Radix Astragali 1-12 Radix Notoginseng 1-10
Eupolyphaga 1-10 Sanguis Draxonis 1-8 Olibanum 1-8 Myrrha 1-8
Os Draconis 1-12 Cortex Phellodendri 1-8 Concha Ostreae 1-12 Caulis Spatholobi 1-10
Parching to brown melon seed 1-12 Bombyx Batryticatus 1-10 Pyritum (calcined) 1-6 Herba Asari 1-3
System river 1-8 Radix Aconiti Kusnezoffii 1-8 Herba Lycopodii 1-10 Radix Glycyrrhizae 1-10
Rhizoma Arisaematis (processed) 1-8 Herba Sarcandrae 1-10 Rhizoma Dioscoreae Nipponicae 1-8 Hirudo 1-8
Semen Strychni (processed) 1-3.
Herbal raw material Herba Epimedii of the present invention has kidney invigorating and YANG supporting, bone and muscle strengthening, the effect of wind-damp dispelling.The Herba Epimedii decoct contains polysaccharide and total flavones, and to playing a role clearly of platelet aggregation, after the healthy human oral Herba Epimedii decoct, red blood cell hematocrit obviously reduces, and erythrocyte electrophoretic time shortens, and erythrocyte sedimentation rate is accelerated, thereby whole blood contrast viscosity is obviously reduced; Experiment showed, that Herba Epimedii has the anabolic effect that promotes medullary cell DNA, illustrates that Herba Epimedii has the osteoporotic effect of good control.Colla cornus cervi is sweet salty, warm, temperature compensation Liver and kidney, beneficial intensive culture blood; Promote the absorption and the intravital retention of calcium, make that calcium slightly increases in the blood, this calcareous carrying effect may be relevant with its contained glycine, and calcium can reduce capillary permeability, makes and oozes out minimizing, and antiinflammatory, detumescence and anti-allergic effects are arranged.The two (Herba Epimedii, Colla cornus cervi) closes and is monarch, plays the effect of invigorating the kidney and strengthening the bones, nourishing blood and promoting blood circulation altogether.Benefiting QI for activating blood circulation such as the Radix Astragali, Radix Angelicae Sinensis, Rhizoma Chuanxiong, Radix Achyranthis Bidentatae, Sanguis Draxonis, Radix Salviae Miltiorrhizae, Caulis Spatholobi, eupolyphaga in the side, with agent of the stasis of blood clearly of eliminating the phlegm such as Olibanum, Myrrha, Scorpio, Scolopendra, the Radix Angelicae Dahuricae, Pheretima, Bombyx Batryticatus, can remove the pathological state that the local expectorant stasis of blood is handed over resistance, promptly remove pathological metabolism product and pro-inflammatory cytokine, the high sticking and tissue degeneratiaon's edema of antagonism blood reaches the purpose that interrupts the pathology link.The agent of invigorating the liver and kidney such as Rhizoma Drynariae, Fructus Lycii, Herba Epimedii, Colla cornus cervi, bone and muscle strengthening, modern study confirm that the cell regeneration of promotion, tissue repair effect are arranged.The Pyritum (calcined) bone-setting pain stopping, the Radix Rehmanniae, Cortex Phellodendri, Herba Taraxaci heat-clearing and toxic substances removing, modern experimentation proof has the anti-inflammation detumescence effect.All medicines share, extending from the interior to the exterior, and treating both the principal and secondary aspects of a disease, and the effect of an expelling wind and cold, promoting blood circulation to remove obstruction in the collateral, the kidney invigorating bone strengthening, bone-setting pain stopping, and femur head necrosis is had favorable effects.
It is logical to get Herba Epimedii, Colla cornus cervi temperature, and the kidney invigorating strengthening the tendons and bones is the key medicine of treatment femur head necrosis.5 Radixs Astragali, Radix Angelicae Sinensis, Rhizoma Drynariae, Fructus Lycii etc. are inspired healthy energy, and expel wind to dredge collateral such as Scolopendra, Scorpio, Pheretima eliminate the phlegm, the Pyritum (calcined) bone-setting pain stopping, and the descending through sick institute of all medicines of drawing of Radix Achyranthis Bidentatae plays promoting tissue regeneration by removing blood stasis jointly, pain spontaneous recovery and the multiple effect of function.Modern pharmacological research confirms that most medical materials have antiinflammatory, analgesic activity preferably, and the part medical material has good local anesthesia effect, the purpose that can reach and interrupt the pathologic reflex arc, starts local repair mechanism.
Medicine of the present invention is the rule of treatment with replenishing kidney and strengthening bone, blood circulation promoting and blood stasis dispelling, collaterals and relieving pain, select medicines such as Herba Epimedii, Radix Notoginseng, Radix Angelicae Sinensis, Squama Manis, Colla cornus cervi, Rhizoma Drynariae for use, make celestial deer bone ball alive, treat each option share head necrosis, clinical experiment is observed and is obtained satisfactory effect.
The following experiment of medicament selection of the present invention and observation index, further its curative effect of evaluation of science:
Oral, every day 3 times, each 6～8 grams; Obeying 3 months is a course of treatment, and drug withdrawal is 3 days between per course of treatment, continues next course of treatment.
1, retinoic acid is caused the therapeutical effect of femur head necrosis model:
Judge that by indexs such as Electronic Speculum, om observation, bone density detection and hemorheologys the therapeutical effect that retinoic acid is caused the femur head necrosis model is remarkable.
2, to the therapeutical effect of traumatic property femur head necrosis model:
Observe medicine to fracture site hematoma or swelling, and, adopt indexs investigations such as bone density observations, om observation simultaneously the influence of multinucleated giant cell quantity in the medullary cavity, obvious to the therapeutical effect of traumatic femur head necrosis model.
3, blood circulation promoting and blood stasis dispelling experiment:
Adopt the local microcirculation laboratory observation, have the effect of tangible microcirculation improvement and the rehabilitation of promotion bone lesion.
4, analgesic experiment:
By hot plate experiment with turn round the body laboratory observation, has the effect of pain relieving preferably and relief of symptoms.
5, acute toxicity testing
In order to verify the safe and effective of preparation,, find no tangible ill symptoms by acute toxicity testing.
Two of purpose of the present invention can realize by following technical measures:
Finishing the preparation method of the medicine of one of the object of the invention carries out as follows:
A, Radix Angelicae Sinensis, Rhizoma Chuanxiong, Radix Paeoniae Rubra, Rhizoma Et Radix Notopterygii, Radix Angelicae Pubescentis, Herba Asari, the Radix Aucklandiae, the Radix Angelicae Dahuricae are extracted volatile oil with steam distillation, volatile oil and medicinal liquid 1 are standby;
Because this 8 flavor medical material all contains volatile oil, water-soluble components and liposoluble constituent, thus volatile oil extracted earlier, and then water extract-alcohol precipitation.
B, will make the conventional decocting in river, Radix Aconiti Kusnezoffii earlier and boil, merge with a step residue medicinal residues and Radix Gentianae Macrophyllae, Herba Lycopodii, the Radix Rehmanniae, Fructus Lycii, Radix Glycyrrhizae, Flos Lonicerae, Rhizoma Drynariae, Rhizoma Arisaematis (processed) then, conventional extracting in water, medicinal liquid 2 is standby;
Because Radix Gentianae Macrophyllae, Herba Lycopodii, the Radix Rehmanniae, Fructus Lycii, Radix Glycyrrhizae, Flos Lonicerae, Rhizoma Drynariae, Rhizoma Arisaematis (processed) promptly contain water-soluble components, contain liposoluble constituent again,, handle so carry out water extract-alcohol precipitation in order to reduce dosage.
The medicinal liquid 2 that c, the medicinal liquid 1 that a step is extracted and b step are extracted merges, concentrates, concentrated solution 1, in concentrated solution 1, add ethanol then, alcohol deposit fluid, reclaim ethanol, concentrate, concentrated solution 2;
D, get the conventional extracting in water of Herba Lycopodii, Herba Epimedii, Herba Taraxaci, Caulis Spatholobi, Cortex Phellodendri, Herba Sarcandrae, the Radix Astragali, Radix Ophiopogonis, Fructus Forsythiae, Rhizoma Dioscoreae Nipponicae, extracting solution, concentrate, concentrated solution 3;
Because this 10 herbal medicine mainly contains water-soluble components, proposes processing so carry out water.
E, Radix Achyranthis Bidentatae, Poria, Radix Salviae Miltiorrhizae, the Cortex Eucommiae, Squama Manis, Pheretima, Scorpio, Scolopendra, Bombyx Batryticatus, eupolyphaga, Hirudo, Colla cornus cervi, Sanguis Draxonis, Olibanum, Myrrha, Radix Notoginseng, Semen Strychni (processed), Os Draconis, Concha Ostreae, Pyritum (calcined), Semen Cucumidis sativi (parched) are ground into micropowder, the mixing of 300～320um, the crude drug powder;
This part flavour of a drug or contain effective composition and should not extract with conventional method, or be animal drugs, valuable medicine, toxicity medical material, therefore directly pulverize and be used as medicine.Wherein, Colla cornus cervi, Olibanum, Myrrha and other drug string powder, Semen Strychni, Radix Notoginseng are pulverized separately
The concentrated solution 3 of f, the concentrated solution 2 of getting the c step and d step merges mixing, adds the volatile oil of a step extraction and the crude drug powder of e step and makes pill.
The specific embodiment:
Embodiment 1:
A, get Radix Angelicae Sinensis 10k
g, Rhizoma Chuanxiong 1k
g, Radix Paeoniae Rubra 12k
g, Rhizoma Et Radix Notopterygii 1k
g, Radix Angelicae Pubescentis 12k
g, Herba Asari 1k
g, Radix Aucklandiae 10k
g, Radix Angelicae Dahuricae 1k
gExtract volatile oil with steam distillation, it is standby to get volatile oil and medicinal liquid 1;
B, will make river 1k earlier
g, Radix Aconiti Kusnezoffii 8k
gConventional decocting boils, then with a step residue medicinal residues and Radix Gentianae Macrophyllae 12k
g, Herba Lycopodii 1k
g, Radix Rehmanniae 10k
g, Fructus Lycii 1k
g, Radix Glycyrrhizae 10k
g, Flos Lonicerae 1k
g, Rhizoma Drynariae 10k
g, Rhizoma Arisaematis (processed) 1k
gMerge, conventional extracting in water, it is standby to get medicinal liquid 2;
The medicinal liquid 2 that c, the medicinal liquid 1 that a step is extracted and b step are extracted merges, concentrates, concentrated solution 1, in concentrated solution 1, add ethanol then, alcohol deposit fluid, reclaim ethanol, concentrate, concentrated solution 2;
D, get Herba Lycopodii 1k
g, Herba Epimedii 12k
g, Herba Taraxaci 1k
g, Caulis Spatholobi 10k
g, Cortex Phellodendri 1k
g, Herba Sarcandrae 10k
g, Radix Astragali 1k
g, Radix Ophiopogonis 12k
g, Fructus Forsythiae 1k
g, Rhizoma Dioscoreae Nipponicae 8k
gConventional extracting in water gets extracting solution, concentrates, and gets concentrated solution 3;
E, with Radix Achyranthis Bidentatae 10k
g, Poria 1k
g, Radix Salviae Miltiorrhizae 12k
g, Cortex Eucommiae 1k
g, Squama Manis 10k
g, Pheretima 1k
g, Scorpio 10k
g, Scolopendra 1k
g, Bombyx Batryticatus 10k
g, eupolyphaga 1k
g, Hirudo 8k
g, Colla cornus cervi 1k
g, Sanguis Draxonis 8k
g, Olibanum 1k
g, Myrrha 8k
g, Radix Notoginseng 1k
g, Semen Strychni (processed) 3k
g, Os Draconis 1k
g, Concha Ostreae 12k
g, Pyritum (calcined) 1k
g, Semen Cucumidis sativi (parched) 12k
gBe ground into micropowder, the mixing of 320um, get the crude drug powder;
The concentrated solution 3 of f, the concentrated solution 2 of getting the c step and d step merges mixing, adds the volatile oil of a step extraction and the crude drug powder of e step and makes pill.
Embodiment 2:
A, get Radix Angelicae Sinensis 1k
g, Rhizoma Chuanxiong 8k
g, Radix Paeoniae Rubra 1k
g, Rhizoma Et Radix Notopterygii 12k
g, Radix Angelicae Pubescentis 1k
g, Herba Asari 3k
g, Radix Aucklandiae 1k
g, Radix Angelicae Dahuricae 10k
gExtract volatile oil with steam distillation, it is standby to get volatile oil and medicinal liquid 1;
B, will make river 8k earlier
g, Radix Aconiti Kusnezoffii 1k
gConventional decocting boils, then with a step residue medicinal residues and Radix Gentianae Macrophyllae 1k
g, Herba Lycopodii 10k
g, Radix Rehmanniae 1k
g, Fructus Lycii 12k
g, Radix Glycyrrhizae 1k
g, Flos Lonicerae 12k
g, Rhizoma Drynariae 1k
g, Rhizoma Arisaematis (processed) 8k
gMerge, conventional extracting in water, it is standby to get medicinal liquid 2;
The medicinal liquid 2 that c, the medicinal liquid 1 that a step is extracted and b step are extracted merges, concentrates, concentrated solution 1, in concentrated solution 1, add ethanol then, alcohol deposit fluid, reclaim ethanol, concentrate, concentrated solution 2;
D, get Herba Lycopodii 12k
g, Herba Epimedii 1k
g, Herba Taraxaci 12k
g, Caulis Spatholobi 1k
g, Cortex Phellodendri 8k
g, Herba Sarcandrae 1k
g, Radix Astragali 12k
g, Radix Ophiopogonis 1k
g, Fructus Forsythiae 12k
g, Rhizoma Dioscoreae Nipponicae 1k
gConventional extracting in water gets extracting solution, concentrates, and gets concentrated solution 3;
E, with Radix Achyranthis Bidentatae 1k
g, Poria 12k
g, Radix Salviae Miltiorrhizae 1k
g, Cortex Eucommiae 10k
g, Squama Manis 1k
g, Pheretima 10k
g, Scorpio 1k
g, Scolopendra 10k
g, Bombyx Batryticatus 1k
g, eupolyphaga 10k
g, Hirudo 1k
g, Colla cornus cervi 12k
g, Sanguis Draxonis 1k
g, Olibanum 8k
g, Myrrha 1k
g, Radix Notoginseng 10k
g, Semen Strychni (processed) 1k
g, Os Draconis 12k
g, Concha Ostreae 1k
g, Pyritum (calcined) 6k
g, Semen Cucumidis sativi (parched) 1k
gBe ground into micropowder, the mixing of 300um, get the crude drug powder;
The concentrated solution 3 of f, the concentrated solution 2 of getting the c step and d step merges mixing, adds the volatile oil of a step extraction and the crude drug powder of e step and makes pill.
Embodiment 3:
A, get Radix Angelicae Sinensis 5k
g, Rhizoma Chuanxiong 4k
g, Radix Paeoniae Rubra 6k
g, Rhizoma Et Radix Notopterygii 6k
g, Radix Angelicae Pubescentis 6k
g, Herba Asari 2k
g, Radix Aucklandiae 5k
g, Radix Angelicae Dahuricae 5k
gExtract volatile oil with steam distillation, it is standby to get volatile oil and medicinal liquid 1;
B, will make river 4k earlier
g, Radix Aconiti Kusnezoffii 4k
gConventional decocting boils, then with a step residue medicinal residues and Radix Gentianae Macrophyllae 6k
g, Herba Lycopodii 5k
g, Radix Rehmanniae 5k
g, Fructus Lycii 6k
g, Radix Glycyrrhizae 5k
g, Flos Lonicerae 6k
g, Rhizoma Drynariae 5k
g, Rhizoma Arisaematis (processed) 4k
gMerge, conventional extracting in water, it is standby to get medicinal liquid 2;
The medicinal liquid 2 that c, the medicinal liquid 1 that a step is extracted and b step are extracted merges, concentrates, concentrated solution 1, in concentrated solution 1, add ethanol then, alcohol deposit fluid, reclaim ethanol, concentrate, concentrated solution 2;
D, get Herba Lycopodii 6k
g, Herba Epimedii 6k
g, Herba Taraxaci 6k
g, Caulis Spatholobi 5k
g, Cortex Phellodendri 4k
g, Herba Sarcandrae 5k
g, Radix Astragali 6k
g, Radix Ophiopogonis 6k
g, Fructus Forsythiae 6k
g, Rhizoma Dioscoreae Nipponicae 4k
gConventional extracting in water gets extracting solution, concentrates, and gets concentrated solution 3;
E, with Radix Achyranthis Bidentatae 5k
g, Poria 6k
g, Radix Salviae Miltiorrhizae 6k
g, Cortex Eucommiae 5k
g, Squama Manis 5k
g, Pheretima 5k
g, Scorpio 5k
g, Scolopendra 5k
g, Bombyx Batryticatus 5k
g, eupolyphaga 5k
g, Hirudo 4k
g, Colla cornus cervi 6k
g, Sanguis Draxonis 4k
g, Olibanum 4k
g, Myrrha 4k
g, Radix Notoginseng 5k
g, Semen Strychni (processed) 2k
g, Os Draconis 6k
g, Concha Ostreae 6k
g, Pyritum (calcined) 3k
g, Semen Cucumidis sativi (parched) 6k
gBe ground into micropowder, the mixing of 310um, get the crude drug powder;
The concentrated solution 3 of f, the concentrated solution 2 of getting the c step and d step merges mixing, adds the volatile oil of a step extraction and the crude drug powder of e step and makes pill.
Claims (2)
1, a kind of medicine for the treatment of femur head necrosis is characterized in that it is the pill of being made by the herbal raw material of following weight parts proportioning:
Herba Epimedii 1-12 Colla cornus cervi 1-12 Radix Achyranthis Bidentatae 1-10 Radix Gentianae Macrophyllae 1-12
Flos Lonicerae 1-12 1-12 Radix Ophiopogonis Radix Paeoniae Rubra 1-12 Radix Salviae Miltiorrhizae 1-12
Poria 1-12 Squama Manis 1-10 Fructus Forsythiae 1-12 Pheretima 1-10
Scorpio 1-10 Scolopendra 1-10 Herba Lycopodii 1-12 Radix Angelicae Sinensis 1-10
Herba Taraxaci 1-12 Rhizoma Et Radix Notopterygii 1-12 Radix Angelicae Pubescentis 1-12 Radix Angelicae Dahuricae 1-10
Rhizoma Chuanxiong 1-8 Cortex Eucommiae 1-10 Radix Rehmanniae 1-10 Fructus Lycii 1-12
Rhizoma Drynariae 1-10 Radix Aucklandiae 1-10 Radix Astragali 1-12 Radix Notoginseng 1-10
Eupolyphaga 1-10 Sanguis Draxonis 1-8 Olibanum 1-8 Myrrha 1-8
Os Draconis 1-12 Cortex Phellodendri 1-8 Concha Ostreae 1-12 Caulis Spatholobi 1-10
Parching to brown melon seed 1-12 Bombyx Batryticatus 1-10 Pyritum (calcined) 1-6 Herba Asari 1-3
System river 1-8 Radix Aconiti Kusnezoffii 1-8 Herba Lycopodii 1-10 Radix Glycyrrhizae 1-10
Rhizoma Arisaematis (processed) 1-8 Herba Sarcandrae 1-10 Rhizoma Dioscoreae Nipponicae 1-8 Hirudo 1-8
Semen Strychni (processed) 1-3.
2, the described a kind of preparation method for the treatment of the medicine of femur head necrosis of claim 1 is characterized in that this preparation method carries out as follows:
A, Radix Angelicae Sinensis, Rhizoma Chuanxiong, Radix Paeoniae Rubra, Rhizoma Et Radix Notopterygii, Radix Angelicae Pubescentis, Herba Asari, the Radix Aucklandiae, the Radix Angelicae Dahuricae are extracted volatile oil with steam distillation, volatile oil and medicinal liquid 1 are standby;
B, will make the conventional decocting in river, Radix Aconiti Kusnezoffii earlier and boil, merge with a step residue medicinal residues and Radix Gentianae Macrophyllae, Herba Lycopodii, the Radix Rehmanniae, Fructus Lycii, Radix Glycyrrhizae, Flos Lonicerae, Rhizoma Drynariae, Rhizoma Arisaematis (processed) then, conventional extracting in water, medicinal liquid 2 is standby;
The medicinal liquid 2 that c, the medicinal liquid 1 that a step is extracted and b step are extracted merges, concentrates, concentrated solution 1, in concentrated solution 1, add ethanol then, alcohol deposit fluid, reclaim ethanol, concentrate, concentrated solution 2;
D, get the conventional extracting in water of Herba Lycopodii, Herba Epimedii, Herba Taraxaci, Caulis Spatholobi, Cortex Phellodendri, Herba Sarcandrae, the Radix Astragali, Radix Ophiopogonis, Fructus Forsythiae, Rhizoma Dioscoreae Nipponicae, extracting solution, concentrate, concentrated solution 3;
E, Radix Achyranthis Bidentatae, Poria, Radix Salviae Miltiorrhizae, the Cortex Eucommiae, Squama Manis, Pheretima, Scorpio, Scolopendra, Bombyx Batryticatus, eupolyphaga, Hirudo, Colla cornus cervi, Sanguis Draxonis, Olibanum, Myrrha, Radix Notoginseng, Semen Strychni (processed), Os Draconis, Concha Ostreae, Pyritum (calcined), Semen Cucumidis sativi (parched) are ground into micropowder, the mixing of 300～320um, the crude drug powder;
The concentrated solution 3 of f, the concentrated solution 2 of getting the c step and d step merges mixing, adds the volatile oil of a step extraction and the crude drug powder of e step and makes pill.
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