CN1762509B - Acupoint electrostimulation device and method for improving cerebral function - Google Patents
Acupoint electrostimulation device and method for improving cerebral function Download PDFInfo
- Publication number
- CN1762509B CN1762509B CN200410083855.1A CN200410083855A CN1762509B CN 1762509 B CN1762509 B CN 1762509B CN 200410083855 A CN200410083855 A CN 200410083855A CN 1762509 B CN1762509 B CN 1762509B
- Authority
- CN
- China
- Prior art keywords
- output
- intensity
- interface
- current
- clock
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Fee Related
Links
- 238000000034 method Methods 0.000 title abstract description 13
- 230000002490 cerebral effect Effects 0.000 title 1
- 238000001467 acupuncture Methods 0.000 claims abstract description 39
- 230000003925 brain function Effects 0.000 claims abstract description 25
- 239000004973 liquid crystal related substance Substances 0.000 claims abstract description 8
- 230000004936 stimulating effect Effects 0.000 claims abstract description 7
- 230000000638 stimulation Effects 0.000 claims description 31
- 238000004804 winding Methods 0.000 claims description 18
- 230000006870 function Effects 0.000 claims description 10
- 230000001105 regulatory effect Effects 0.000 claims description 9
- 239000013078 crystal Substances 0.000 claims description 8
- 230000005284 excitation Effects 0.000 claims description 6
- 230000001276 controlling effect Effects 0.000 claims description 4
- 238000013461 design Methods 0.000 claims description 4
- 230000002085 persistent effect Effects 0.000 claims description 4
- 239000003990 capacitor Substances 0.000 claims description 3
- 230000002441 reversible effect Effects 0.000 claims description 3
- 230000000737 periodic effect Effects 0.000 claims description 2
- 230000000694 effects Effects 0.000 abstract description 6
- 230000005611 electricity Effects 0.000 abstract description 5
- 239000003814 drug Substances 0.000 abstract description 3
- 231100000252 nontoxic Toxicity 0.000 abstract 1
- 230000003000 nontoxic effect Effects 0.000 abstract 1
- 230000015654 memory Effects 0.000 description 13
- 241000700159 Rattus Species 0.000 description 11
- 238000002474 experimental method Methods 0.000 description 6
- 238000006243 chemical reaction Methods 0.000 description 5
- 238000010586 diagram Methods 0.000 description 5
- 238000009792 diffusion process Methods 0.000 description 4
- 239000000499 gel Substances 0.000 description 4
- 230000036541 health Effects 0.000 description 4
- 238000004519 manufacturing process Methods 0.000 description 4
- 238000012347 Morris Water Maze Methods 0.000 description 3
- 210000004556 brain Anatomy 0.000 description 3
- 230000007423 decrease Effects 0.000 description 3
- 238000005516 engineering process Methods 0.000 description 3
- 230000007794 irritation Effects 0.000 description 3
- 239000000203 mixture Substances 0.000 description 3
- 239000000758 substrate Substances 0.000 description 3
- 210000004958 brain cell Anatomy 0.000 description 2
- 230000002950 deficient Effects 0.000 description 2
- 239000007788 liquid Substances 0.000 description 2
- 230000007087 memory ability Effects 0.000 description 2
- 238000001208 nuclear magnetic resonance pulse sequence Methods 0.000 description 2
- 239000004033 plastic Substances 0.000 description 2
- 229920003023 plastic Polymers 0.000 description 2
- 230000003014 reinforcing effect Effects 0.000 description 2
- 238000011160 research Methods 0.000 description 2
- 230000001225 therapeutic effect Effects 0.000 description 2
- 241001465754 Metazoa Species 0.000 description 1
- 102000003797 Neuropeptides Human genes 0.000 description 1
- 108090000189 Neuropeptides Proteins 0.000 description 1
- 241001122767 Theaceae Species 0.000 description 1
- 230000032683 aging Effects 0.000 description 1
- 235000013361 beverage Nutrition 0.000 description 1
- 230000008859 change Effects 0.000 description 1
- 230000003111 delayed effect Effects 0.000 description 1
- 238000010304 firing Methods 0.000 description 1
- 235000013402 health food Nutrition 0.000 description 1
- 230000036571 hydration Effects 0.000 description 1
- 238000006703 hydration reaction Methods 0.000 description 1
- 230000006872 improvement Effects 0.000 description 1
- 238000011534 incubation Methods 0.000 description 1
- 239000004615 ingredient Substances 0.000 description 1
- 230000006386 memory function Effects 0.000 description 1
- 239000002184 metal Substances 0.000 description 1
- 210000000653 nervous system Anatomy 0.000 description 1
- 239000004745 nonwoven fabric Substances 0.000 description 1
- 230000006886 spatial memory Effects 0.000 description 1
- 231100000331 toxic Toxicity 0.000 description 1
- 230000002588 toxic effect Effects 0.000 description 1
- 238000012549 training Methods 0.000 description 1
Images
Landscapes
- Finger-Pressure Massage (AREA)
- Electrotherapy Devices (AREA)
Abstract
The invention relates to a device with electricity stimulating the acupuncture points to promote the brain function, comprising: liquid crystal display screen, at least two pairs of electrodes, and a pulse generator constructed by a monolithic system, the A B ways of output circuit for constant current and press key unit; the D/A interface of the A B ways is connected with the two ways output circuit for constant current respectively, the output end is connected with the electrode, the monolithic system is connected with the liquid crystal display screen; the monolithic system is connected with the press key unit, one end of the press key unit is connected with earth. The electrical impulse signal of 2Hz, 100 Hz, or 2/100 Hz alternatively output by the constant current output circuit stimulates the acupuncture points through the electrodes equipped on the two different acupuncture points on the body. The method combined with the acupuncture point theory of the traditional medicine of China activates the body autogenous mechanism to promote the brain function by the stimulating the acupuncture points with electricity; the method and device is safe, nontoxic and non side effect, which can be used in long run.
Description
Technical field
The present invention relates to a kind of apparatus and method that can promote brain function, particularly relate to a kind of acupuncture point electrical stimulation device and acupuncture point electrical stimulation method that promotes brain function.
Background technology:
People's the actual in life brain cell of using up that makes is less than one of total percentage, even the most genius scientist has also only employed few part of brain cell lifetime.Therefore, do not need to worry that what people more paid close attention to is the decline that how to slow down brain function, and give full play to the potentiality of brain for the minimizing of neurocyte.For example in fact improving memory is exactly to avoid as far as possible and overcome forgeing, and this point improves school grade and delay the decline of memory of elderly person power especially important for adolescent student.Existing market has a lot of these type of health foods and medicine such as various oral liquid, health tea and beverage etc., these products have certain function of health care to human body, but many scientific researches without strictness confirm that it truly has the effect that improves brain function, memory reinforcing, and price is generally relatively more expensive, and the course of treatment is long.In addition, other has a series products such as learning and memory box, card etc. also to claim to improve memory ability, this series products mainly is to use some cards, character word stock etc. to allow consumer carry out the training of learning and memory, perhaps, this method can help the skill of some learning and memories of people's acquistion, but in fact memory ability be there is no real raising effect, the hypomnesis due to the aging is not had clear and definite curative effect yet.The instrument that also has some to utilize electromagnetic principle to make, or electronic equipment etc. also claim can memory reinforcing, but the same with the said goods, all do not have the corresponding experiment support and prove its effectiveness.In addition, the circuit that existing this quasi-instrument adopts electronic components such as resistance and electric capacity to build, so the circuit complexity, makes time-consuming, instrument volume greatly, cost is also high, and carries and use equal inconvenience.
Goal of the invention
The objective of the invention is to: overcome above-mentioned existing raising adolescents with learning achievement or delay the price comparison costliness that the various health care oral liquids, therapeutic instrument etc. of memory of elderly person power decline exist, the course of treatment is long, and most defectives such as scientific research demonstration without strictness; It is big to overcome above-mentioned equipment circuit complexity, the instrument volume of making of electronic devices and components, and carries and use inconvenient defective; Thereby a kind of non-therapeutic purposes are provided, modern electronic technology is combined with the acupuncture theory of China traditional Chinese medical science, promote acupuncture point electrical stimulation device and the acupuncture point electrical stimulation method of brain function comprehensively.The object of the present invention is achieved like this:
The acupuncture point electrical stimulation device that can promote brain function provided by the invention comprises: can alternately export the electric pulse generator 11 of 2Hz, 100Hz or 2/100Hz electric impulse signal, be electrically connected by lead 13 and at least two counter electrode 12; It is characterized in that, also comprise liquid crystal display (hereinafter to be referred as LCD), described pulse generator is by Single Chip Microcomputer (SCM) system, A, B two-way constant current output circuit, and key groups constitutes; A intensity D/A interface by single-chip microcomputer is connected with A, B two-way constant current output circuit respectively with B intensity D/A interface, the outfan connection electrode 12 of two-way constant current output circuit, this constant current output circuit is exported positive and negative alternative electric impulse signal, the frequency of output pulse comprises 2,100,2/100Hz, when output frequency is 2Hz, pulse width is 0.6mS; When output frequency is 100Hz, pulse width is 0.2mS; When output frequency is the 2/100Hz dilatational wave, pulse width is 0.6mS when 2Hz, is 0.2mS when 100Hz, and the persistent period of two kinds of frequencies is 3 seconds, promptly per 3 seconds conversion one secondary frequencies and pulsewidth, constantly alternately, continuous firing; Wherein single-chip microcomputer is electrically connected with liquid crystal display; Single-chip microcomputer is electrically connected with key groups, key groups one end ground connection.
Described pulse generator is core with the single-chip microcomputer, by software control A, B two-way constant current output circuit, can choose the spike train of 3 kinds of waveforms wantonly, and the intensity (pulse peak current) of every road output is from 0-50mA, and with the increment of every ladder 1mA, plus-minus is regulated arbitrarily.But 3 kinds of working times of preliminary election during start, 30,45,60 minutes, regularly arrive, instrument cuts off the power supply automatically.The duty of instrument shows that by liquid crystal display (LCD) displaying contents comprises: intensity, waveform, countdown timing etc.
Described single-chip microcomputer is the core of this machine, this single-chip microcomputer has can provide the precision clock crystal oscillator, also has the I/O interface of selecting periodic I/O interface, selecting A, B two-way output waveform, control A, B two-way output intensity increase (+), subtract the interface of (-): intensity A+, intensity A-, the I/O interface of intensity B+, intensity B-, amount to 6 input ports, each interface connects a function button respectively: and have A intensity D/A delivery outlet, B intensity D/A delivery outlet, clock 1 output and clock 2 delivery outlets, amount to 4 delivery outlets.
Described control A road output intensity I/O interface, by output of the D/A in the single-chip microcomputer and the corresponding analog quantity of A road intensity, in order to the intensity of control A road output constant current output, its analog voltage is 0-1.25V, respective pulses peak point current 0-50mA.
Described control B road output intensity I/O interface, by output of the D/A in the single-chip microcomputer and the corresponding analog quantity of B road intensity, in order to the intensity of control B road output constant current output, its analog voltage is 0-1.25V, respective pulses peak point current 0-50mA
Described clock 1I/O interface, the clock pulses of the odd indexed in the output waveform spike train is provided, clock 1 and clock 2 alternative excitation constant current output circuits make output obtain just (odd indexed), negative (even number sequence number) the alternative spike train (Fig. 4) of selected frequency waveform.
Described clock 2I/O interface provides the clock pulses of the even number sequence number in the output waveform spike train, and clock 2 and clock 1 alternative excitation constant current output circuit make output obtain negative (the even number sequence number) of selected frequency waveform, (odd indexed) alternative spike train just.
Above every function of single-chip microcomputer all relies on complete function setting software to realize its flow chart such as Fig. 7.
Described A, B two-way constant current output circuit are identical, and the two works alone, and does not disturb mutually.Be somebody's turn to do " constant current output circuit " (is example with the A road) as shown in Figure 5, audion Q6 and Q7 constitute on-off circuit, difference series limiting resistor R13 and R14 on Q6 and Q7 base stage, the two row pulses control that its base stage is sent by the clock 2 and the clock 1 of single-chip microcomputer respectively works in the on off state of alternate conduction.The equal ground connection of the emitter stage of audion Q6 and Q7, colelctor electrode is connected on the two ends of the elementary winding of centre tapped output transformer B1 respectively, constitute push-pull output circuit, make and produce in the elementary winding of output transformer B1 alternate and pulse current that direction is opposite, the odd and even number sequence number that obtains in the B1 secondary windings is reverse train of pulse mutually, and this train of pulse passes through socket J1 through lead 13, electrode 12 stimulating acupoints.The sequential of the train of pulse of output as shown in Figure 4.
The centre cap of the elementary winding of described output transformer B1 is received the colelctor electrode as the audion Q5 of constant-current source, by the current intensity of the elementary winding of output transformer B1, depends on the collector current Ic5 of audion Q5; The emitter stage of audion Q5 meets voltage source V DO, and C7 is the decoupling capacitor of VDO; The base stage of audion Q5 connects the colelctor electrode of audion Q4, ground connection behind the emitter stage series resistance R12 of Q4 and the adjustable resistance R11.The base stage of Q4 connects the A intensity D/A output of single-chip microcomputer.Because output transformer B1 designs by current transformer, so, its secondary windings can form constant current output in the 0-2KOhm load, its output continuous current intensity I p (pulse peak current) scope is 0-50mA, and this output Constant Electric Current flow valuve can be by the direct regulating and controlling of 0-1.25V aanalogvoltage of single-chip microcomputer " A intensity D/A " output.The aanalogvoltage of strength control adds to the base stage of crystal triode Q4, is used for regulating its collector current Ic4.And Ic4 is the base current Ib5 of audion Q5, and it controls the size of Q5 collector current Ic5, realizes the constant-current source feed to output transformer B1.This device constant-current source output circuit output current intensity scope can be calibrated by the adjustable resistance R11 on the emitter circuit that is serially connected in crystal triode Q4.
Described electrode comprises a kind of electrode of percutaneous stimulation, and its structure as shown in Figure 2; Or US-4926828, the disclosed electrode of EP-0225241.
Application provided by the invention can promote the acupuncture point electrical stimulation device of brain function to carry out the acupuncture point electrical stimulation method, may further comprise the steps:
1. use the acupuncture point electrical stimulation device that can promote brain function of the present invention, two counter electrode that install are placed respectively on two Different Acupoint of limbs, as Nei Guan and Wai Guan, or on connected valleys and the tsu san li;
2. start powers on, the instrument zero clearing resets, and enters initial condition, exports positive and negative alternative electric impulse signal, and the frequency of the pulse of exporting comprises 2Hz, 100Hz, 2/100Hz, and when output frequency is 2Hz, pulse width is 0.6mS; When output frequency is 100Hz, pulse width is 0.2mS; When output frequency is the 2/100Hz dilatational wave, pulse width is 0.6mS when 2Hz, when 100Hz 0.2mS, the persistent period of two kinds of frequencies is 3 seconds, be per 3 seconds conversion one secondary frequencies and pulsewidth, alternative electric pulse stimulation Nei Guan and Wai Guan, or acupuncture point on connected valleys and the tsu san li, stimulation time is 30/45/60 minute.
Application provided by the invention can promote the acupuncture point electrical stimulation device of brain function to carry out the acupuncture point electrical stimulation method, comprises following concrete steps:
1. use the acupuncture point electrical stimulation device that can promote brain function of the present invention, two counter electrode that install are placed respectively on two Different Acupoint of limbs, as Nei Guan and Wai Guan, or on connected valleys and the tsu san li;
2. start powers on, the instrument zero clearing resets, and enters initial condition, according to the following steps:
Step 2.1) enters default (acquiescence) state 1; This state is the timing value set condition, and default (acquiescence) value is 30 minutes, and LCD shows 30min, checks self-timing setting button, and this moment, timing value became 45 fens, again by becoming 60 fens if press once " regularly " options button; Constantly by circulation becomes with regard to 30-45-60-30-45-60, up to confirming one of them, LCD has corresponding the demonstration simultaneously;
Step 2.2) enter default (acquiescence) state 2: this state is the wave setting state, during default (acquiescence) state, the frequency of waveform is 2/100Hz (LCD demonstration), whenever presses the waveform key once, changes by following order: 2/100-2-100-2/100 (LCD shows in real time);
Step 2.3) output current intensity that enters default (acquiescence) state 3:A and B passage is zero (LCD shows 0mA), check A, intensity "+" "-" button of B passage, "+" key of passage is pressed once, intensity increases 1mA (LCD demonstration) automatically, up to maximum 50mA (LCD demonstration);
Step 2.4) "-" key of passage is pressed once, and intensity reduces 1mA (LCD demonstration), up to minima 0mA (LCD shows not);
Step 2.5) in case the intensity of A, two passages of B is 0mA, also continues to pin intensity "-" button and do not decontrol, continue more than 2 seconds, instrument closes tester in power-down state automatically;
Step 2.6) enters normal operating conditions, A intensity D/A, B intensity D/A, clock 1 and clock 2 four road signals that output is set, 2Hz, 100Hz or the alternative electric impulse signal of 2/100Hz of instrument output;
Step 2.7) then with step 2.6) 2Hz, 100Hz or the alternative electric pulse stimulation Nei Guan of 2/100Hz and the Wai Guan of output, or acupuncture point on connected valleys and the tsu san li, stimulation time is 30/45/60 minute.
When the LCD of instrument shows automatic countdown, as 30-29-28-----min; In case to clocking value is 0min, instrument closes tester in power-down state automatically.
The invention has the advantages that: the acupuncture point electrical stimulation device that can promote brain function provided by the invention, with the Single Chip Microcomputer (SCM) system is core, A, the B two-way constant current output circuit of controlling electric pulse generator 11 respectively by the A intensity D/A interface and the B intensity D/A interface of single-chip microcomputer, two outfans of electric pulse generator 11 are through lead 13 connection electrode 12,2Hz, the 100Hz of this pulse generator output or the positive and negative alternative electric impulse signal of 2/100Hz, by contacting at Nei Guan and Wai Guan, or connected valleys and Zusanli point top electrode, reach the effect of electric stimulate of point.Like this in conjunction with the acupuncture theory in China's traditional medicine, pass through electric stimulate of point, promote that nervous system discharges different neurotransmitteies and neuropeptide respectively, improve the learning and memory function of brain, represent this apparatus and method through animal experiment, the brain that has the people has facilitation, particularly can improve school grade concerning adolescent student, can delay hypomnesis to the old people, but this instrument and method are a kind of health care instrument and health-care method of safe without toxic side effect life-time service.
This instrument adopts the chip microcontroller of advanced electronic technology and chip manufacturing, and it makes simple, need not build its circuit by a large amount of electronic devices and components, so the volume of instrument reduces widely, cost of manufacture has also reduced, and carry and use also convenient.
Description of drawings
Fig. 1 is the composition diagram that the present invention promotes the acupuncture point electrical stimulation device of brain function
Shown in Figure 2 is the profile of electrode that stimulating apparatus of the present invention uses 12
Shown in Figure 3 is the block diagram of pulse generator
Fig. 4 is the pulse sequence figure that the acupuncture point electricity irritation improves the device of memory
Fig. 5 is A road " constant current output circuit " composition diagram among Fig. 1
Fig. 6 is with the influence figure of stimulating apparatus of the present invention to the directed experiment of rat Morris water maze
(n=12 represents the routine number of every group of rat among the figure)
Fig. 7 single-chip microcomputer workflow diagram
The specific embodiment
The composition of the acupuncture point electrical stimulation device of promotion brain function provided by the invention comprises electric pulse generator 11, lead 13 and electrode 12 as shown in Figure 1.
Wherein electrode 12 is electrodes of a percutaneous stimulation, and its structure comprises as shown in Figure 2: a substrate sticks layer 25 (this substrate sticks layer 25 non-woven fabrics commonly used or plastic production); One is positioned at the conductive diffusion layer 22 (conductive diffusion layer 22 common metal paper tinsels or conductive plastics film production) that substrate sticks layer 25 inboard; At the center that sticks layer 25 and conductive diffusion layer 22 conductive pole 24 is arranged, one end of this conductive pole 24 is the disks that radially extend, the other end is a spheroplast, and this spheroplast extends to the outside that sticks layer 25 and is enough to make the snap-fastener 23 of conduction to form the press-button type connection with it.In the inboard of conductive diffusion layer 22, comprise that there is the gel layer 26 (these gel layer 26 usefulness hydration high-molecular gels are made) of a conduction conductive pole 24 bottoms, it is in the outermost layer of electrode, directly contacts with the human body skin acupuncture point, plays a part bonding reliably and conduction.At non-working condition, electrode have a releasable protecting film 27 with stick the layer 25 and gel layer 26 be connected.During use,, above-mentioned electrode is placed on the said acupuncture point as long as protecting film 27 is removed.Kind electrode also can be US-4926828, the disclosed electrode of EP-0225241.
Shown in Figure 3 is the block diagram of pulse generator of the acupuncture point electrical stimulation device of promotion brain function provided by the invention, it is core with the single-chip microcomputer, by software control A, B two-way constant current output circuit, can choose the spike train of 3 kinds of waveforms wantonly, the intensity (pulse peak current) of every road output is from 0-50mA, with the increment of every ladder 1mA, plus-minus is regulated arbitrarily.But 3 kinds of working times of preliminary election during start, 30,45,60 minutes, regularly arrive, instrument cuts off the power supply automatically.The duty of instrument shows that by liquid crystal display (LCD) content comprises: intensity, waveform, countdown timing etc.
Introduce each ingredient of pulse generator below in detail.
1. Single Chip Microcomputer (SCM) system: it is the core of this machine, except that crystal oscillator provides precision clock, also has the I/O mouth of following function:
1.16 individual input button, function is as follows:
(1) regularly: in when start, at first set the working time and be a kind of in 30/45/60, the working time is when arriving, instrument autostop, outage.
(2) waveform: the waveform of selected instrument output spike train, have 3 kinds, promptly 2,100,2/100Hz, and when choosing 2Hz, at clock 1,2 delivery outlets of single-chip microcomputer, spike train that will the final Synthetic 2 Hz of output, and pulse width is 0.6mS.When choosing 100Hz, at clock 1,2 delivery outlets, with the spike train of the final synthetic 100Hz of output, and pulse width is 0.2mS.During the 2/100Hz dilatational wave,, will export the dilatational wave spike train of final Synthetic 2/100Hz in elected at clock 1,2 delivery outlets of single-chip microcomputer, and pulse width is 0.6mS when 2Hz, be 0.2mS when 100Hz, the persistent period of two kinds of frequencies is 3 seconds, promptly per 3 seconds conversion one secondary frequencies and pulsewidth.
(3) intensity A+: A road output intensity increases, every button once, output intensity increases 1mA.Maximum is output as 50mA.
(4) intensity A-: A road output intensity reduces, every button once, output intensity reduces 1mA.Minimum is output as 0mA.
(5) intensity B+:B road output intensity increases, every button once, output intensity increases 1mA.Maximum is output as 50mA.
(6) the defeated intensity in intensity B-:B road goes out to reduce, every button once, output intensity reduces 1mA.Minimum is output as 0mA.
1.24 individual delivery outlet, the waveform and the intensity of control A, the output of B two-way are respectively:
(1) A intensity D/A: by output of the D/A in the single-chip microcomputer and the corresponding analog quantity of A road intensity, in order to the intensity of control A road output constant current output, its magnitude of voltage is 0-1.25V, respective pulses peak point current 0-50mA
(2) B intensity D/A: by output of the D/A in the single-chip microcomputer and the corresponding analog quantity of B road intensity, in order to the intensity of control B road output constant current output, its magnitude of voltage is 0-1.25V, respective pulses peak point current 0-50mA
(3) clock 1: the clock pulses of the odd indexed in the last output spike train is provided, and it and clock 2 alternative excitation constant current output circuits make output obtain just (odd indexed) negative (even number sequence number) alternative spike train.
(4) clock 2: the clock pulses of the even number sequence number in the last output spike train is provided, and it and clock 1 alternative excitation constant current output circuit make output obtain negative (even number sequence number) just (odd indexed) alternative spike train.
Above every function of single-chip microcomputer all relies on complete software to realize.
2. constant current output circuit: instrument has A, the output of B two-way, and circuit is identical, and the two works alone, and does not disturb mutually.
Circuit shown in Figure 5 is A road " constant current output circuit " among Fig. 1, audion Q6 among the figure and Q7 constitute on-off circuit, the two row pulses control that its base stage is sent by the clock 2 and the clock 1 of single-chip microcomputer among Fig. 3 respectively, on Q6 and Q7 base stage, distinguish series limiting resistor R13 and R14, work in the on off state of alternate conduction.The equal ground connection of the emitter stage of audion Q6 and Q7, colelctor electrode is connected on the two ends of the elementary winding of centre tapped output transformer B1 respectively, constitute push-pull output circuit, make and produce in the elementary winding of output transformer B1 alternate and pulse current that direction is opposite, the odd and even number sequence number that obtains in the B1 secondary windings is reverse train of pulse mutually, and this train of pulse passes through socket J1 through lead 13, electrode 12 stimulating acupoints.The sequential of the train of pulse of output as shown in Figure 4.
The centre cap of the elementary winding of output transformer B1 is received the colelctor electrode as the audion Q5 of constant-current source, by the current intensity of the elementary winding of output transformer B1, depends on the collector current Ic5 of audion Q5.The emitter stage of audion Q5 meets voltage source V DO, and C7 is the decoupling capacitor of VDO.The base stage of audion Q5 connects the colelctor electrode of audion Q4, ground connection behind the emitter stage series resistance R12 of Q4 and the adjustable resistance R11.The base stage of Q4 connects the A intensity D/A output of single-chip microcomputer.Because output transformer B1 designs by current transformer, so, its secondary windings can form constant current output in the 0-2KOhm load, its output continuous current intensity I p (pulse peak current) scope is 0-50mA, and this output Constant Electric Current flow valuve can be by the direct regulating and controlling of 0-1.25V aanalogvoltage of single-chip microcomputer " A intensity D/A " output.The aanalogvoltage of strength control adds to the base stage of crystal triode Q4, is used for regulating its collector current Ic4.And Ic4 is the base current Ib5 of audion Q5, and it controls the size of Q5 collector current Ic5, realizes the constant-current source feed to output transformer B1.This device constant-current source output circuit output current intensity scope can be calibrated by the adjustable resistance R11 on the emitter circuit that is serially connected in crystal triode Q4.
Single-chip microcomputer workflow (as shown in Figure 7) among the present invention comprises the steps:
Step 101: start powers on.
Step 102: zero clearing resets, and enters initial condition.
Step 103: enter default (acquiescence) state 1.This state is the timing value set condition, and default (acquiescence) value is 30 minutes, and LCD shows 30min, checks self-timing setting button, and this moment, timing value became 45 fens, again by becoming 60 fens if press once " regularly " options button.Constantly by circulation becomes with regard to 30-45-60-30-45-60, up to confirming one of them, LCD has corresponding the demonstration simultaneously
Step 104: enter default (acquiescence) state 2: this state is the wave setting state, during default (acquiescence) state, the frequency of waveform is 2/100Hz (LCD demonstration), whenever presses the waveform key once, changes by following order: 2/100-2-100-2/100 (LCD shows in real time).
Step 105: the output current intensity that enters default (acquiescence) state 3:A and B passage is zero (LCD shows 0mA),
Check A, intensity "+" "-" button of B passage, "+" key of passage is pressed once, and intensity increases 1mA (LCD demonstration) automatically, up to maximum 50mA (LCD demonstration).
"-" key of passage is pressed once, and intensity reduces 1mA (LCD demonstration), up to minima 0mA (LCD demonstration).
In case the intensity of A, two passages of B is 0mA, also continue to pin intensity "-" button and do not decontrol, continue more than 2 seconds, instrument closes tester in power-down state automatically.
Step 106: enter normal operating conditions, A intensity D/A, B intensity D/A, clock 1 and clock 2 four road signals that output is set.The LCD of instrument shows automatic countdown, as 30-29-28-----min.In case to clocking value is 0min, instrument closes tester in power-down state automatically.
Fig. 4 is the pulse sequence figure that the acupuncture point electricity irritation improves the device of memory.
Use the present invention the device that the acupuncture point electricity irritation improves memory has been obtained proof in rat experiment.
Adopt traditional rat Morris water maze model as the space learning memory models, 48 rats are divided into 4 groups at random: matched group, constraint group, 2Hz acusector group, 100Hz acusector group.For observing the influence of acusector to the spatial memory ability, giving 5 2Hz or 100Hz acusector after the Morris watermaze protocol handles, and the achievement that relatively directed experiment and space exploration are tested before and after acusector, experimental result as shown in figure 13, rats in normal control group and the run away prolongation of latency (in other words memory disappear) of rat in the orientation experiment of handling through constraint, and this change does not appear in 2Hz or 100Hz acusector group rat.And be significantly shorter than rats in normal control group and constraint group rat (promptly obviously having delayed rat forgeing) incubation period of runing away of 2Hz group to recall info.Shown in the result with reference to Fig. 6.
The applicant has made detailed explanation with regard to design of the present invention and embodiment; should be understood that; also can make various conversion and improvement for this professional those of ordinary skill on the basis of the above description, when these conversion with improve all within the claimed scope of appending claims of the present invention.
Claims (8)
1. acupuncture point electrical stimulation device that promotes brain function comprises: pulse generator 11 is electrically connected by lead 13 and two counter electrode 12 at least; It is characterized in that, also comprise liquid crystal display, described pulse generator is by Single Chip Microcomputer (SCM) system, A, B two-way constant current output circuit, and key groups constitutes; Wherein the A road D/A interface of single-chip microcomputer is connected with A, B two-way constant current output circuit respectively with B road D/A interface, the outfan connection electrode 12 of two-way constant current output circuit, 2Hz, 100Hz that this constant current output circuit is alternately exported or the electric impulse signal of 2/100Hz, when output frequency was 2Hz, pulse width was 0.6mS; When output frequency was 100Hz, pulse width was 0.2mS; When output frequency was the 2/100Hz dilatational wave, pulse width was 0.6mS when 2Hz, was 0.2mS when 100Hz, and the persistent period of two kinds of frequencies is 3 seconds, and wherein single-chip microcomputer is electrically connected with liquid crystal display; Single-chip microcomputer is electrically connected with key groups, key groups one end ground connection.
2. press the acupuncture point electrical stimulation device of the described promotion brain function of claim 1, it is characterized in that, described pulse generator comprises single-chip microcomputer, by a function setting software is installed, control the pulse signal output of A, the optional 3 kinds of frequencies of B two-way constant current output circuit, the intensity of every road output is from 0-50mA, and with the increment of every ladder 1mA, plus-minus is regulated arbitrarily; Function setting software is controlled the available machine time, but 3 kinds of working times of this available machine time preliminary election 30,45,60 minutes, regularly arrive, automatically outage.
3. press the acupuncture point electrical stimulation device of the described promotion brain function of claim 2, it is characterized in that, described single-chip microcomputer has can provide the precision clock crystal oscillator, also has periodic I/O interface, the I/O interface of waveform, the I/O interface that control A road output intensity increases, the I/O interface that reduces with control A road output intensity, the I/O interface that control B road output intensity increases, the I/O interface that reduces with control B road output intensity, totally 6 kinds of I/O interfaces, each interface connects a function button respectively: and have A road output intensity D/A delivery outlet, B road output intensity D/A delivery outlet, clock 1 output interface and clock 2 output interfaces.
4. press the acupuncture point electrical stimulation device of the described promotion brain function of claim 3, it is characterized in that, the numerical value of described A road output continuous current intensity I p, A intensity D/A interface by single-chip microcomputer, the magnitude of voltage of output 0-1.25V, the A road constant current output circuit of clamp-pulse generator, the pulse peak current of output 0-50mA.
5. press the acupuncture point electrical stimulation device of the described promotion brain function of claim 3, it is characterized in that, the numerical value of described B road output continuous current intensity I p, B intensity D/A interface by single-chip microcomputer, the magnitude of voltage of output 0-1.25V, the B road constant current output circuit of clamp-pulse generator, the pulse peak current of output 0-50mA.
6. press the acupuncture point electrical stimulation device of the described promotion brain function of claim 3, it is characterized in that, described clock 1 output interface, the clock pulses of the odd indexed in the last output spike train is provided, it and clock 2 alternative excitation constant current output circuits make output obtain positive and negative alternative spike train; Described clock 2 output interfaces provide the clock pulses of the even number sequence number in the last output spike train, and clock 1 and clock 2 output alternative excitation constant current output circuits make output obtain positive and negative alternative spike train.
7. press the acupuncture point electrical stimulation device of the described promotion brain function of claim 2, it is characterized in that, described constant current output circuit comprises: audion Q6 and Q7 constitute on-off circuit, difference series limiting resistor R13 and R14 on Q6 and Q7 base stage, the two row pulses control that its base stage is sent by the clock 2 and the clock 1 of single-chip microcomputer respectively works in the on off state of alternate conduction; The equal ground connection of the emitter stage of audion Q6 and Q7, colelctor electrode is connected on the two ends of the elementary winding of centre tapped output transformer B1 respectively, constitute push-pull output circuit, make and produce in the elementary winding of output transformer B1 alternate and pulse current that direction is opposite, the odd and even number sequence number that obtains in the B1 secondary windings is reverse train of pulse mutually, and this train of pulse passes through socket J1 through lead 13, electrode 12 stimulating acupoints; The centre cap of the elementary winding of output transformer B1 is received the colelctor electrode as the audion Q5 of constant-current source, by the current intensity of the elementary winding of output transformer B1, depends on the collector current Ic5 of audion Q5; The emitter stage of audion Q5 meets voltage source V DO, and C7 is the decoupling capacitor of VDO; The base stage of audion Q5 connects the colelctor electrode of audion Q4, ground connection behind the emitter stage series resistance R12 of Q4 and the adjustable resistance R11; The base stage of Q4 connects the A intensity D/A interface output of described single-chip microcomputer; The aanalogvoltage of strength control adds to the base stage of crystal triode Q4, is used for regulating its collector current Ic4; And Ic4 is the base current Ib5 of audion Q5, and it controls the size of Q5 collector current Ic5, realizes the constant-current source feed to output transformer B1.
8. press the acupuncture point electrical stimulation device of the described promotion brain function of claim 7, it is characterized in that, described output transformer B1 designs by current transformer, its secondary windings forms constant current output in the 0-2KOhm load, its output continuous current intensity I p scope is 0-50mA, and this output Constant Electric Current flow valuve is by the direct regulating and controlling of 0-1.25V aanalogvoltage of described single-chip microcomputer " A intensity D/A " interface output.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN200410083855.1A CN1762509B (en) | 2004-10-20 | 2004-10-20 | Acupoint electrostimulation device and method for improving cerebral function |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN200410083855.1A CN1762509B (en) | 2004-10-20 | 2004-10-20 | Acupoint electrostimulation device and method for improving cerebral function |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| CN1762509A CN1762509A (en) | 2006-04-26 |
| CN1762509B true CN1762509B (en) | 2010-05-26 |
Family
ID=36746964
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN200410083855.1A Expired - Fee Related CN1762509B (en) | 2004-10-20 | 2004-10-20 | Acupoint electrostimulation device and method for improving cerebral function |
Country Status (1)
| Country | Link |
|---|---|
| CN (1) | CN1762509B (en) |
Families Citing this family (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN101708353B (en) * | 2008-08-14 | 2012-11-21 | 上海交通大学 | Multi-site simulating electrode array for brain stimulation |
| CN104548341A (en) * | 2014-12-20 | 2015-04-29 | 江门百脉医疗器械有限公司 | Performance detection method of micro-current stimulator |
| CN106039553B (en) * | 2016-06-13 | 2018-08-24 | 重庆医药高等专科学校 | Constant current electrical stimulation circuit that electrod-array is nonpolarity |
| CN105944231A (en) * | 2016-06-28 | 2016-09-21 | 浙江中医药大学 | Acupoint electrical stimulation method and device for auxiliary treatment of inflammatory pain |
| CN106983957A (en) * | 2017-04-05 | 2017-07-28 | 中国人民解放军第二军医大学 | Anti-blooming ship fatigue hand knee ring |
| CN108031002B (en) * | 2018-02-08 | 2021-06-29 | 中国医科大学附属盛京医院 | Electrical stimulation apparatus for promoting regeneration of autograft fat flap |
Citations (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP0225241A1 (en) * | 1985-11-19 | 1987-06-10 | General Electric Cgr S.A. | Coreless-type high-frequency current transformer |
| US4926828A (en) * | 1988-03-01 | 1990-05-22 | Honda Giken Kogyo K.K. | Air-fuel ratio feedback control method for internal combustion engines |
| CN1060968A (en) * | 1990-11-02 | 1992-05-13 | 赵贵春 | Soberizing apparatus for drowsing |
| CN1094647A (en) * | 1994-03-22 | 1994-11-09 | 何京 | Automatic Jing and Luo and acupoint treating apparatus |
| CN2482999Y (en) * | 2001-04-21 | 2002-03-27 | 李连坤 | Massage hypnotic device |
-
2004
- 2004-10-20 CN CN200410083855.1A patent/CN1762509B/en not_active Expired - Fee Related
Patent Citations (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP0225241A1 (en) * | 1985-11-19 | 1987-06-10 | General Electric Cgr S.A. | Coreless-type high-frequency current transformer |
| US4926828A (en) * | 1988-03-01 | 1990-05-22 | Honda Giken Kogyo K.K. | Air-fuel ratio feedback control method for internal combustion engines |
| CN1060968A (en) * | 1990-11-02 | 1992-05-13 | 赵贵春 | Soberizing apparatus for drowsing |
| CN1094647A (en) * | 1994-03-22 | 1994-11-09 | 何京 | Automatic Jing and Luo and acupoint treating apparatus |
| CN2482999Y (en) * | 2001-04-21 | 2002-03-27 | 李连坤 | Massage hypnotic device |
Also Published As
| Publication number | Publication date |
|---|---|
| CN1762509A (en) | 2006-04-26 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| CN206792806U (en) | A kind of low frequency transcutaneous stimulation instrument of multi-channel multi-parameter bipolarity constant current | |
| US9327134B2 (en) | Implantable electroacupuncture device and method | |
| CN101069769A (en) | Needle-free pain-relieving instrument and its setting method | |
| JPH0226510B2 (en) | ||
| CN101234233A (en) | Transcranial magnetic field stimulator stimulus strength modulating method and device therefor | |
| JP2004513750A (en) | Electroacupuncture device with stimulation electrode unit | |
| CN106388929A (en) | Isolated type square wave irreversible electroporation apparatus | |
| CN104740766B (en) | Ear is worn through cranium micro-current stimulator | |
| CN203355132U (en) | Electrical acupoint stimulation apparatus having vola physiotherapy function | |
| CN1762509B (en) | Acupoint electrostimulation device and method for improving cerebral function | |
| CN203556061U (en) | Transcranial stimulation apparatus | |
| CN204951946U (en) | Swallow neural muscle electricity stimulation instrument | |
| CN208785590U (en) | A kind of hardware circuit of pain electric pulse therapeutic equipment | |
| CN207640809U (en) | A kind of pulse generating circuit through cranial nerve physical therapy apparatus | |
| CN1166366A (en) | Thinking and sleeping brain wave simulating equipment | |
| CN202844366U (en) | Chinese medicine acupoint electrical stimulation instrument | |
| CN1026659C (en) | Multi-function painless acupuncture instrument | |
| CN1137738C (en) | Electronic insomnia treating instrument | |
| CN107819459A (en) | Negative oxygen ion generator | |
| CN217119143U (en) | Cervical vertebra massager with function of adjusting human sleep rhythm electric activity by low-frequency pulse magnetic field | |
| CN2778315Y (en) | Dedicated portable electric ion introduction therapeutic device for hyperthyroidism | |
| CN210696981U (en) | Health care pillow capable of emitting low frequency | |
| CN201418951Y (en) | Electronic anti-dizzy and anti-vomit instrument | |
| CN2280530Y (en) | Device for analogue of thought and sleep brain-wave | |
| CN203620077U (en) | Electronic analgesia instrument |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| C06 | Publication | ||
| PB01 | Publication | ||
| C10 | Entry into substantive examination | ||
| SE01 | Entry into force of request for substantive examination | ||
| ASS | Succession or assignment of patent right |
Owner name: HEFEI AOLI INTELLIGENT SYSTEM CO., LTD. Free format text: FORMER OWNER: CUI CAILIAN Effective date: 20080926 |
|
| C41 | Transfer of patent application or patent right or utility model | ||
| TA01 | Transfer of patent application right |
Effective date of registration: 20080926 Address after: Floor six, Institute of circular economy engineering, Chinese Academy of Sciences, No. 2221 Changjiang Road, Hefei, 230088 Applicant after: HEFEI AOLI INTELLIGENT SYSTEM Co.,Ltd. Address before: Postal code 38, Beijing, Xueyuan Road: 100083 Applicant before: Cui Cailian |
|
| C14 | Grant of patent or utility model | ||
| GR01 | Patent grant | ||
| ASS | Succession or assignment of patent right |
Owner name: LI XIAOBING Free format text: FORMER OWNER: HEFEI ALEPH INTELLIGENT SYSTEMS CO., LTD. Effective date: 20111229 Owner name: ZHANG WENGE Effective date: 20111229 |
|
| C41 | Transfer of patent application or patent right or utility model | ||
| COR | Change of bibliographic data |
Free format text: CORRECT: ADDRESS; FROM: 230088 HEFEI, ANHUI PROVINCE TO: 100143 HAIDIAN, BEIJING |
|
| TR01 | Transfer of patent right |
Effective date of registration: 20111229 Address after: 100143 Beijing Haidian District No. 8 Yuquanlu Road yuhaiyuan District No. 18 in 206 Co-patentee after: Zhang Wenge Patentee after: Li Xiaobing Address before: 230088, No. 2221 Changjiang Road, Anhui, six floor, Institute of circular economy engineering, Chinese Academy of Sciences, Hefei Patentee before: HEFEI AOLI INTELLIGENT SYSTEM Co.,Ltd. |
|
| TR01 | Transfer of patent right | ||
| TR01 | Transfer of patent right |
Effective date of registration: 20170405 Address after: 230088 Hefei province hi tech Zone, Anhui Province, No. 252, Hefei Institute of automotive engineering technology research center, Institute of technology,, Room 408, 409-2 Patentee after: HEFEI AOLI INTELLIGENT SYSTEM Co.,Ltd. Address before: 100143 Beijing Haidian District No. 8 Yuquanlu Road yuhaiyuan District No. 18 in 206 Patentee before: Li Xiaobing Patentee before: Zhang Wenge |
|
| CF01 | Termination of patent right due to non-payment of annual fee |
Granted publication date: 20100526 Termination date: 20211020 |
|
| CF01 | Termination of patent right due to non-payment of annual fee |