CN101234233A - Transcranial magnetic field stimulator stimulus strength modulating method and device therefor - Google Patents
Transcranial magnetic field stimulator stimulus strength modulating method and device therefor Download PDFInfo
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- CN101234233A CN101234233A CNA2008100468228A CN200810046822A CN101234233A CN 101234233 A CN101234233 A CN 101234233A CN A2008100468228 A CNA2008100468228 A CN A2008100468228A CN 200810046822 A CN200810046822 A CN 200810046822A CN 101234233 A CN101234233 A CN 101234233A
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Abstract
The invention relates to a method used in modulating the stimulation intensity of transcranial magnetic field stimulators and a device thereof, which is characterized in that: various changing modulation waves and changing stimulating frequencies are given off by a microcomputer controller simultaneously; the voltage of an energy dumped capacitor reaches to the given value of modulation waves by the sampling of a sampling circuit and the controlling of the comparator in charging of the energy dumped capacitor; magnetic field output energy changes with the transformation of modulation waves and carrier waves and becomes dual-dynamic amplitude and frequency modulation wave through the triggering of a thyristor electronic switch by the microcomputer controller. The method used in modulating the stimulation intensity of transcranial magnetic field stimulators and a device thereof cause the output intensity of the magnetic field to change momentarily, and causes the induced current in vivo to change along with the output intensity of the magnetic field. The output wave type modulated dynamically with a plurality of parameters enriches the change of magnetic field stimulation, has a fresh feeling, uneasy to generate adaptability and tolerability, thus improving the treatment efficacy.
Description
Technical field
The present invention relates to a kind of transcranial magnetic field stimulator stimulus intensity modulator approach and device thereof, a kind of have an output modulation function, and the size of stimulating coil output current is serializing, modulationization, and variation, output parameter is by the transcranial magnetic field stimulator of computer program control.
Background technology
Transcranial magnetic field stimulate be in the stimulating coil moment (200 is delicate) pulse current by thousands of amperes, according to electromagnetic induction principle, produce pulsed magnetic field around the coil perpendicular to coil plane, the magnetic field of transition can be lossless by scalp and skull, result from the opposite faradic current of stimulating coil in brain inside, if current's intensity reaches the threshold potential of nerve fiber, just can cause the depolarization of cell membrane potential, and cause the excitement of nervus centralis.This phenomenon occurs in peripheral nervous equally, because magnetic stimulation is undamped by human body, and not damaged, no pain, contactless, the essence of magnetic stimulation is the electricity irritation of body induced currents, but obviously is better than electricity irritation.Therefore be widely used in the research of neuroscience, clinical medical diagnosis, treatment and rehabilitation.The principle of magnetic stimulation is to charge to storage capacitor with DC high-voltage power supply, discharge to stimulating coil as electrical switch with controllable silicon, huge pulse current makes coil produce powerful pulsed magnetic field, the magnetic field of transition can make during near human body organization internal produce faradic current, thereby cause the neurocyte excitement, muscle contraction, hormone secretion touches a series of biological effects such as prominent modulation.
At present, the magnetic field stimulator on the market is divided into manual stimulation and Automatic Program stimulus modelity, and manually stimulating is by press button, the manual triggers reverse-blocking tetrode thyristor, and the single stimulation of formation, frequency is less than 1Hz, and being called the single of low frequency stimulates.Can cause neural once impulsion, the once contraction of innervation flesh, the nerve that is suitable for taking exercises brings out the inspection of current potential.Automatically stimulate to the repetitive stimulation under the computer program control, be called the high frequency repetitive stimulation when frequency is higher than 1Hz, be mainly used in the treatment of nerve, mental sickness.As stimulate brain, and treatment depression, apoplexy sequela, in rehabilitation medicine, being used for functional magnetic stimulates, treatment constipation and gatism.
Present magnetic field stimulator has only constant sequence (clump shape) stimulation of intensity in single stimulation and the stimulation in treatment, effect of stimulation makes the people feel unexpected and dull, with low uncertainty, uncomfortable, is easy to generate adaptability, toleration, and therapeutic effect is descended.
Summary of the invention
Stimulate output shortcoming with low uncertainty in order to overcome existing transcranial magnetic field stimulator, for the comfort that improves when treatment, in order to reduce the adaptability in the treatment, improve the sensitivity of treatment, strengthen therapeutic effect, the invention provides a kind of transcranial magnetic field stimulator stimulus intensity modulator approach and device thereof, the magnetic field output intensity is changed at any time, intravital faradic current is also changed thereupon.It is abundant that the output wave mode of multiparameter dynamic modulation changes magnetic stimulation, feels fresh, is not easy to produce adaptability and toleration, thereby improve therapeutic effect.
The technical solution adopted for the present invention to solve the technical problems is: a kind of transcranial magnetic field stimulator stimulus intensity modulator approach, it is characterized in that: the modulating wave of various variations and the stimulus frequency of variation (carrier wave) are sent by microcomputer controller simultaneously, through sample circuit sampling and the charging of comparator control storage capacitor, make storage capacitor voltage reach the modulating wave set-point, trigger the controllable silicon electrical switch by microcomputer controller again, realize that magnetic field output energy changes along with the conversion of modulating wave and carrier wave, becomes two dynamic amplitude modulation frequency-modulated waves.
Aforesaid transcranial magnetic field stimulator stimulus intensity modulator approach is characterized in that:
The modulating wave instruction repertorie of microcomputer controller 7 is finished various modulation waveforms through PWM output by filter shape;
High voltage charging power supply 1 charges to storage capacitor 3 by current-limiting resistance 2 under the control of comparator 10;
The pressure sampling circuit of being made up of upper end sample resistance 8 and lower end sample resistance 9 detects the voltage of storage capacitor 3, by the be provided with sequence of microcomputer controller 7 according to modulation waveform, the positive pole of receiving comparator input terminal as given voltage is as the modulation input, when the voltage of storage capacitor 3 is charged to the voltage of modulation waveform setting, comparator 10 output electronegative potentials, allow high voltage charging power supply 1 quit work, send carrier pulse by microcomputer controller 7 again, trigger reverse-blocking tetrode thyristor 5 conductings, finish discharge by reverse-blocking tetrode thyristor to magnetic stimulation coil 6 by storage capacitor 3; Finish the whole modulating wave cycle successively.
Aforesaid transcranial magnetic field stimulator stimulus intensity modulator approach is characterized in that:
The mathematical model of various waveforms is set by microcomputer, change the different variablees in the mathematical formulae, change modulation waveform, on computer screen, show multiparameter dynamic modulation waveform, carrier frequency, output, accumulative total stimulates number, stimulation time, modulation waveform is one or more in the following waveform: sine wave, square wave, triangular wave, trapezoidal wave, staircase waveform, sawtooth waveforms, exponential wave, the differential ripple, the integration ripple, increase progressively, the wave of oscillation successively decreases, its modulation depth, modulating wave is wide, sawtooth waveforms, exponential wave, the differential ripple, the time of integration ripple rising edge and trailing edge, the platform time of trapezoidal wave, staircase waveform progression, the equal scalable of number of repetition is compiled into the output waveform sequential chart, become the abundant therapeutic scheme of conversion, with its storage with call.
A kind of stimulus intensity can synthetic transcranial magnetic field stimulator, it comprises high voltage charging power supply 1, current-limiting resistance 2, storage capacitor 3, reverse fly-wheel diode 4, reverse-blocking tetrode thyristor 5, magnetic stimulation coil 6 and microcomputer controller 7, it is characterized in that: it also comprises upper end sample resistance 8, lower end sample resistance 9 and comparator 10, the pressure sampling circuit that upper end sample resistance 8 and lower end sample resistance 9 are formed is connected in parallel on the storage capacitor 3, mid point is received the negative input of comparator 10, microcomputer controller 7 is according to the sequence that is provided with of modulation waveform, the positive pole of receiving comparator input terminal as given voltage is as the modulation input, and the outfan of comparator 10 connects the control end of high voltage charging power supply 1.
The output wave mode that the invention has the beneficial effects as follows the multiparameter dynamic modulation makes the magnetic stimulation variation abundant, feels fresh, is not easy to produce adaptability and toleration, thereby improves therapeutic effect.
Description of drawings
Fig. 1 is the circuit theory diagrams of the embodiment of the invention.
Fig. 2 is the sketch map of frequency modulation output waveform and sinusoidal modulation wave.
Fig. 3 is the sketch map of square wave, triangular wave, sawtooth waveforms.
Fig. 4 is the sketch map of trapezoidal wave, staircase waveform, differential ripple and integration ripple.
The specific embodiment
The present invention is further described below in conjunction with drawings and Examples.
The explanation of Fig. 1 labelling: 1-high voltage charging power supply, 2-charging current limiter resistance, 3-storage capacitor, the reverse fly-wheel diode of 4-, 5-reverse-blocking tetrode thyristor, 6-stimulating coil, 7-microcomputer controller, 8-upper end sample resistance, 9-lower end sample resistance, 10-comparator.
Among Fig. 2, on to arrange waveform be general sequence (clump shape) waveform, centre be harmonic shape between sine, following row is a sine company harmonic shape.
Among Fig. 3, last row is the square-wave frequency modulation waveform, and the centre is the triangular modulation waveform, and following row is the sawtooth waveforms modulation waveform.
Among Fig. 4, last row is the trapezoidal wave modulation waveform, and the centre is the staircase waveform modulation waveform, and following row is differential ripple and integration ripple modulation waveform.
The realization of modulating wave through PWM output, is finished various modulation waveforms by filter shape by the modulating wave instruction repertorie of microcomputer controller 7 in Fig. 1.High voltage charging power supply 1 is subjected to the control of comparator 10, when comparator 10 is output as high potential, high voltage charging power supply 1 work is also passed through current-limiting resistance 2 to storage capacitor 3 chargings, form pressure sampling circuit by upper end sample resistance 8 and lower end sample resistance 9, detect the voltage of storage capacitor 3, and receive the negative input of comparator 10, by the be provided with sequence of microcomputer controller 7 according to modulation waveform, the positive pole of receiving comparator input terminal as given voltage is as the modulation input, when the voltage of storage capacitor 3 is charged to the voltage of modulation waveform setting, sampling voltage is little when being higher than given voltage, comparator 10 output electronegative potentials allow high voltage charging power supply 1 quit work, and send carrier pulse by microcomputer controller 7 again, trigger reverse-blocking tetrode thyristor 5 conductings, finish discharge by reverse-blocking tetrode thyristor to magnetic stimulation coil 6 by storage capacitor 3; Finish the whole modulating wave cycle successively.
In Fig. 2, last row is the train wave output waveform of frequency modulation; Stimulus frequency in its train wave changes, amplitude inconvenience.
Middle row is the sinusoidal wave intermittently modulation of programming, and it is provided with parameter and comprises Sine Modulated wave frequency (ripple is wide), modulation amplitude (modulation depth), intermittent time, carrier frequency, maximum output, minimum output.Its mathematical model is:
Wherein T is train wave working cycle (carrier cycle), and A is a modulation amplitude, and N represents the train wave number in the work pulsewidth.
Following row figure is the continuous modulation of several sine waves, and output time prolongs, and the intermission shortens.Its mathematical model is:
f(t)＝Asin(2πf
0t)
F wherein
0The expression modulating frequency, A is a modulation amplitude.
In Fig. 3, last row adds an intermittence after two square waves connect accent.
Wherein T is a carrier cycle, and N represents the train wave number in the work pulsewidth.M represents segments, and every period is NT/M, A
i, i=1,2 ... M is every section a amplitude,
Middle row is single triangular modulation waveform,
Wherein T is the train wave working cycle, and A is an amplitude, and N represents the train wave number in the work pulsewidth.
Following row is the sawtooth waveforms modulation waveform, the amplitude of triangular wave, time-histories, and the upper edge of sawtooth waveforms, fall time, modulation amplitude all can independently be set.Mathematical model is
Wherein T is the train wave working cycle, and A is an amplitude, and N represents the train wave number in the work pulsewidth.T
mExpression sawtooth waveforms modulation signal maximum time corresponding point.
In Fig. 4, last row can be provided with rise time, fall time, platform time for the trapezoidal wave modulation, intermittent time, modulation degree, carrier frequency, and output.Mathematical model is:
Wherein T is the train wave working cycle, and A is an amplitude, and N represents the wide interior train wave number of modulating wave.T
1And T
2Be starting point and the terminal point of plateau.
Middle waveform is the staircase waveform modulation, and the parameter that can be provided with is: the ladder number, and the ladder time-histories, ladder percentage ratio is differential, minimum and the differential ratio of maximum.
Wherein T is the train wave working cycle, and A is an amplitude, and N represents to modulate the train wave number in the pulsewidth.
Following row is differential ripple and integration ripple (exponential wave and logarithm ripple), and the initial variation of differential ripple is little, converted quantity in time increase and exponentially increases, the integration phase of wave is anti-, initial variable quantity is big, changes little subsequently.Its mathematical model is:
Wherein T is a carrier cycle, and A is an amplitude, and N represents to modulate the train wave number in the pulsewidth.Change the convex-concave degree that the b value can change adjustment curve.
Modulation of the present invention is exactly that the waveform of various markizations is loaded in original constant sequence (clump shape) magnetic stimulation, load sine wave, square wave, triangular wave, trapezoidal wave, staircase waveform, sawtooth waveforms, exponential wave, logarithm ripple, (differential, the integration ripple) wave of oscillation that increases progressively, successively decreases, can change modulation wave frequency and modulation depth, and the magnetic stimulation frequency also can change, and becomes two dynamic modulation magnetic stimulations.Multiple composite wave modulation stimulates, and produces comfortable joyful stimulation, and changeful stimulation makes magnetic stimulation more acceptant, reaches better therapeutic.
Claims (4)
1, a kind of transcranial magnetic field stimulator stimulus intensity modulator approach, it is characterized in that: the modulating wave of various variations and the stimulus frequency of variation are sent by microcomputer controller simultaneously, through sample circuit sampling and the charging of comparator control storage capacitor, make storage capacitor voltage reach the modulating wave set-point, trigger the controllable silicon electrical switch by microcomputer controller again, realize that magnetic field output energy changes along with the conversion of modulating wave and carrier wave, becomes two dynamic amplitude modulation frequency-modulated waves.
2, transcranial magnetic field stimulator stimulus intensity modulator approach as claimed in claim 1 is characterized in that:
The modulating wave instruction repertorie of microcomputer controller (7) is finished various modulation waveforms through PWM output by filter shape;
High voltage charging power supply (1) charges to storage capacitor (3) by current-limiting resistance (2) under the control of comparator (10);
The pressure sampling circuit of being made up of upper end sample resistance (8) and lower end sample resistance (9) detects the voltage of storage capacitor (3), by the be provided with sequence of microcomputer controller (7) according to modulation waveform, the positive pole of receiving comparator input terminal as given voltage is as the modulation input, when the voltage of storage capacitor (3) is charged to the voltage of modulation waveform setting, comparator (10) output electronegative potential, allow high voltage charging power supply (1) quit work, send carrier pulse by microcomputer controller (7) again, trigger reverse-blocking tetrode thyristor (5) conducting, finish discharge by reverse-blocking tetrode thyristor to magnetic stimulation coil (6) by storage capacitor (3); Finish the whole modulating wave cycle successively.
3, transcranial magnetic field stimulator stimulus intensity modulator approach as claimed in claim 1 or 2 is characterized in that:
The mathematical model of various waveforms is set by microcomputer, change the different variablees in the mathematical formulae, change modulation waveform, on computer screen, show multiparameter dynamic modulation waveform, carrier frequency, output, accumulative total stimulates number, stimulation time, modulation waveform is one or more in the following waveform: sine wave, square wave, triangular wave, trapezoidal wave, staircase waveform, sawtooth waveforms, exponential wave, the differential ripple, the integration ripple, increase progressively, the wave of oscillation successively decreases, its modulation depth, modulating wave is wide, sawtooth waveforms, exponential wave, the differential ripple, the time of integration ripple rising edge and trailing edge, the platform time of trapezoidal wave, staircase waveform progression, the equal scalable of number of repetition is compiled into the output waveform sequential chart, become the abundant therapeutic scheme of conversion, with its storage with call.
4, a kind of stimulus intensity can synthetic transcranial magnetic field stimulator, it comprises high voltage charging power supply (1), current-limiting resistance (2), storage capacitor (3), reverse fly-wheel diode (4), reverse-blocking tetrode thyristor (5), magnetic stimulation coil (6) and microcomputer controller (7), it is characterized in that: it also comprises upper end sample resistance (8), lower end sample resistance (9) and comparator (10), the pressure sampling circuit that upper end sample resistance (8) and lower end sample resistance (9) are formed is connected in parallel on the storage capacitor (3), mid point is received the negative input of comparator (10), microcomputer controller (7) is according to the sequence that is provided with of modulation waveform, the positive pole of receiving comparator input terminal as given voltage is as the modulation input, and the outfan of comparator (10) connects the control end of high voltage charging power supply (1).
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| CN102284133A (en) * | 2011-07-14 | 2011-12-21 | 申炳潮 | High-potential health-care therapeutic apparatus |
| CN102309813A (en) * | 2010-07-01 | 2012-01-11 | 林延龙 | Electromagnetic stimulation device and method |
| CN102614592A (en) * | 2012-04-13 | 2012-08-01 | 刘冀成 | Transient electromagnetic field excitation system for transcranial magnetic stimulation (TMS) in medical field |
| CN105229995A (en) * | 2013-02-22 | 2016-01-06 | 塞恩克公司 | For the method and apparatus of the nerve modulation of the networking of one group of individuality |
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Open date: 20080806 |