CN101234233A - Transcranial magnetic field stimulator stimulus strength modulating method and device therefor - Google Patents

Transcranial magnetic field stimulator stimulus strength modulating method and device therefor Download PDF

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CN101234233A
CN101234233A CN 200810046822 CN200810046822A CN101234233A CN 101234233 A CN101234233 A CN 101234233A CN 200810046822 CN200810046822 CN 200810046822 CN 200810046822 A CN200810046822 A CN 200810046822A CN 101234233 A CN101234233 A CN 101234233A
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China
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wave
modulation
stimulation
magnetic field
comparator
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CN 200810046822
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Chinese (zh)
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余维新
夏正才
孙逸华
廖家华
康 葛
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武汉依瑞德医疗设备新技术有限公司
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Priority to CN 200810046822 priority Critical patent/CN101234233A/en
Publication of CN101234233A publication Critical patent/CN101234233A/en

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Abstract

The invention relates to a method used in modulating the stimulation intensity of transcranial magnetic field stimulators and a device thereof, which is characterized in that: various changing modulation waves and changing stimulating frequencies are given off by a microcomputer controller simultaneously; the voltage of an energy dumped capacitor reaches to the given value of modulation waves by the sampling of a sampling circuit and the controlling of the comparator in charging of the energy dumped capacitor; magnetic field output energy changes with the transformation of modulation waves and carrier waves and becomes dual-dynamic amplitude and frequency modulation wave through the triggering of a thyristor electronic switch by the microcomputer controller. The method used in modulating the stimulation intensity of transcranial magnetic field stimulators and a device thereof cause the output intensity of the magnetic field to change momentarily, and causes the induced current in vivo to change along with the output intensity of the magnetic field. The output wave type modulated dynamically with a plurality of parameters enriches the change of magnetic field stimulation, has a fresh feeling, uneasy to generate adaptability and tolerability, thus improving the treatment efficacy.

Description

^器刺激强度调制方法及其装置技术领域本发明涉及一种经颅磁场刺激器刺激强度调制方法及其装置,一种具有输出调制功能,刺激线圈输出电流的大小为序列化,调制化,多样化,输出参数由电脑程序控制的背景技术经颅磁场刺激是刺激线圈内瞬间(200微妙)通过数千安培的脉冲电流,根据电磁感应原理,线圈周围产生垂直于线圈平面的脉冲磁场,瞬变的磁场可以无损耗通过头皮和颅骨,在大脑内部产生于刺激线圈相反的感应电流,如果电流的强度达到神经纤维的阈电位,便可引起细胞膜电位的去极化,而引起中枢神经的兴奋。 ^ Stimulation intensity modulation method and device TECHNICAL FIELD The present invention relates to a transcranial magnetic stimulator stimulation intensity modulation method and apparatus, having an output modulation function, stimulate the magnitude of the current coil output for serialization, modulation of diverse of the output parameter from the background art transcranial magnetic stimulation is computer controlled instantaneously stimulating coil (200 microseconds) by the pulse current according to the thousands of amperes principle of electromagnetic induction to generate a pulse magnetic field perpendicular to the plane of the coil, around the coil, transient the magnetic field may be no loss through the scalp and skull, the brain is generated inside the coil opposite to a stimulus induced current, if the intensity of the current reaches the threshold potential of nerve fibers, can cause depolarization of the membrane potential, and cause central nervous system excitement. 这一现象同样发生在外周神经,由于磁场刺激通过人体无衰减,无损伤,无疼痛,无接触,磁场刺激的本质是体内感应电流的电刺激,但明显优于电刺激。 This phenomenon also occurs in peripheral nerve, since the magnetic field stimulation through the human body without attenuation, no damage, no pain, no-contact, magnetic stimulation in vivo nature of electrical stimulation induced current, but significantly better than electrical stimulation. 因此广泛应用于神经科学的研究,临床医学的诊断、治疗和康复。 It is widely used in neuroscience research, clinical diagnosis, treatment and rehabilitation. 磁场剌激的原理是用直流高压电源向储能电容充电,用可控硅作为电子开关向剌激线圈放电,巨大的脉冲电流使线圈产生强大的脉冲磁场,瞬变的磁场接近人体时可以使组织内部产生感应电流,从而引起神经细胞兴奋,肌肉收缩,激素分泌,触突调制等一系列生物效应。 The principle is to stimulate magnetic storage capacitor charged by a DC high voltage power source, to use as an electronic switch SCR stimulation coil discharge, a great pulse current coil generates a strong magnetic field pulses, may cause a transient magnetic field close to the body internal organization induced current, causing nerve cell excitability, muscle contraction, hormone secretion, modulation series synapses biological effects. 目前,市场上的磁场剌激器分为手动剌激和程序自动刺激模式,手动刺激是通过按钮开关,手动触发可控硅开关,形成的单个剌激,频率小于lHz,称为低频的单刺激。 Currently, magnetic stimulation on the market into individual stimuli manually and automatically stimulate stimulation mode, a manual stimulus is triggered by a triac button switch, manual forming, it is less than the frequency of lHz, called single low frequency stimulation . 可以引起神经的一次冲动,神经支配肌的一次收縮,适合于做运动神经诱发电位的检查。 Can cause a nerve impulse, nerve once dominated the contraction of muscles, suitable for exercise evoked potentials examination. 自动剌激为电脑程序控制下的重复刺激,频率髙于1Hz时称为高频重复刺激,主要用于神经、精神疾病的治疗。 Automatically repeating stimulation stimulation computer program control, frequency 1Hz at the time referred to Gao high frequency repetitive stimulation, primarily for the treatment of neurological and psychiatric disorders. 如刺激大脑,治疗抑郁症、中风后遗症,在康复医学中,用于功能性磁刺激,治疗便秘和大小便失禁。 As stimulates the brain to treat depression, stroke sequelae, rehabilitation medicine, used functional magnetic stimulation, treatment of constipation and incontinence. 现在的磁场刺激器在治疗中只有单刺激和刺激中强度不变的序列(丛状)剌激,刺激效果使人觉得突然和单调,变化少,不舒适,容易产生适应性、耐受性,使治疗效果下降。 Now magnetic stimulation in treatment of only a single stimulus and stimulus intensity invariant sequence (plexiform) stimulation, and stimulatory effect suddenly people feel monotonous, less change, discomfort, prone adaptability, tolerance, the therapeutic effect is reduced. 发明内容为了克服现有的经颅磁场刺激器刺激输出变化少的缺点,为了提高治疗时的舒适感、为了减少治疗中的适应性,提高治疗的敏感性,增强治疗效果,本发明提供一种经颅磁场刺激器刺激强度调制方法及其装置,使磁场输出强度随时变化,使体内的感应电流也随之变化。 SUMMARY OF THE INVENTION To overcome the conventional transcranial magnetic stimulator to stimulate small change in output disadvantage, in order to improve comfort during the treatment, in order to reduce adaptation therapy, to improve the treatment of sensitivity, enhance the therapeutic effect, the present invention provides a transcranial magnetic stimulation is the stimulation intensity modulation method and apparatus, the output intensity of the magnetic field change at any time, so that the body also changes the induced current. 多参数动态调制的输出波型使磁场刺激变化丰富,感觉新鲜,不容易产生适应性和耐受性,从而提高治疗效果。 Multi-parameter dynamic modulated output waveform changes in the magnetic field stimulation is rich, fresh and not prone to tolerance and adaptability, thereby enhancing the therapeutic effect. 本发明解决其技术问题所采用的技术方案是: 一种经颅磁场刺激器刺激强度调制方法,其特征在于:各种变化的调制波和变化的刺激频率(载波)同时由微电脑控制器发出,经取样电路取样和比较器控制储能电容充电,使储能电容电压达到调制波给定值, 再由微电脑控制器触发可控硅电子开关,实现磁场输出能量随着调制波和载波的变换而变化,成为双动态调幅调频波。 The present invention solves the technical problem using the technical solution is: A transcranial magnetic stimulator stimulation intensity modulation method, comprising: modulating wave that various changes and variations stimulation frequency (carrier wave) emitted simultaneously by a microcomputer controller, and a comparator circuit sampling by the sampling control charging the storage capacitor, the storage capacitor so that the modulated wave voltage reaches a given value, then triggered thyristor electronic switch by the microcomputer controller to achieve magnetic field change with the output energy of the modulation wave and the carrier change, becoming a double dynamic AM-FM wave. 如上所述的经颅磁场刺激器刺激强度调制方法,其特征在于:微电脑控制器7的调制波指令程序经过PWM输出,通过滤波整形完成各种调制波形;高压充电电源1在比较器10的控制下通过限流电阻2向储能电容3充电; 由上端取样电阻8和下端取样电阻9组成的分压取样电路检测储能电容3的电压, 由微电脑控制器7按照调制波形的设置序列,作为给定电压接到比较器输入端的正极作为调制输入,当储能电容3的电压充到调制波形设定的电压时,比较器10输出低电位, 让高压充电电源1停止工作,再由微电脑控制器7发出载波脉冲,触发可控硅开关5导通,由储能电容3通过可控硅开关完成向磁场刺激线圈6的放电;依次完成整个调制波周期。 Transcranial magnetic stimulation described above stimulus intensity modulation method, comprising: a modulated wave instruction of the program microcomputer controller 7 via the PWM output, perform various modulation waveform shaping by the filter; controls the high voltage charging power supply 1 in the comparator 10 by the second charging current limiting resistor to the storage capacitor 3; 8 by the upper end and the lower end of sampling resistor sampling resistor 9 consisting of dividing the storage voltage of the capacitor sampling circuit 3 is detected by the micro-controller 7 is provided in accordance with the sequence modulation waveform, as a given voltage to the positive input of the comparator as the modulation input, when the storage voltage of the capacitor 3 is charged to the voltage modulation waveform setting, the comparator 10 outputs a low potential, so the charging high-voltage power supply 1 is stopped, then the control by the microcomputer 7 produces the carrier pulse, triggered thyristor switch 5 is turned on, the magnetic coil 6 is discharged from the storage capacitor is completed by stimulation thyristor switch 3; in order to complete the entire cycle of the modulation wave. 如上所述的经颅磁场刺激器刺激强度调制方法,其特征在于:由微型计算机设置各种波形的数学模型,改变数学公式中的不同变量,改变调制波形,在电脑屏幕上显示多参数动态调制波形、载波频率、输出量、累计刺激个数、剌激时间,调制波形为下列波形中的一种或多种:正弦波、方波、三角波、梯形波、阶梯波、 锯齿波、指数波、微分波,积分波,递增、递减振荡波,其调制深度,调制波宽,锯齿波、指数波、微分波、积分波上升沿和下降沿的时间、梯形波的平台时间,阶梯波级数, 重复次数均可调节,编制成输出波形时序图,成为变换丰富的治疗方案,将其储存和调用。 Transcranial magnetic stimulation described above stimulus intensity modulation method, comprising: a mathematical model is set by the microcomputer various waveforms, changing different variables in the mathematical formula, changing the modulation waveform displayed on the computer screen multi-parameter dynamic modulation waveform, the carrier frequency, output, the cumulative number of stimulation, stimulation time, the modulation waveform is one or more of the following waveform: sinusoidal, square wave, triangular wave, a trapezoidal wave, a stepped wave, sawtooth wave, exponential wave, wave differential, integral wave, increasing, decreasing oscillation, its modulation depth, width modulated wave, sawtooth wave, a time index wave, differential wave, the rising and falling edges of the integral wave, trapezoidal wave plateau time, staircase series, repetitions can be adjusted, a timing chart of output waveforms compiled, become rich conversion treatment regimen, which store and recall. 一种刺激强度可调制的经颅磁场刺激器,它包括髙压充电电源1、限流电阻2、储能电容3、反向续流二极管4、可控硅开关5、磁场刺激线圈6和微电脑控制器7,其特征在于:它还包括上端取样电阻8、下端取样电阻9和比较器10,上端取样电阻8和下端取样电阻9组成的分压取样电路并联在储能电容3上,中点接到比较器10的负极输入端,微电脑控制器7按照调制波形的设置序列,作为给定电压接到比较器输入端的正极作为调制输入,比较器10的输出端连接高压充电电源1的控制端。 A method for stimulating the transcranial intensity can be modulated magnetic stimulator, comprising Gao voltage charging power supply 1, current limiting resistor 2, the storage capacitors 3, 4 reverse freewheeling diode, thyristor switch 5, the microcomputer 6 and the magnetic stimulation coils the controller 7, characterized in that: an upper end further comprising a sampling resistor 8, the lower end of sampling resistor 9 and the comparator 10, the upper end of the sampling circuit samples voltage dividing resistors connected in parallel to the lower end of sampling resistor 8 and 9, the midpoint of the storage capacitor 3 to the negative input terminal of comparator 10, micro-controller 7 is provided in accordance with the sequence modulation waveform as given voltage to the positive input of the comparator as the modulation input, the output of comparator 10 is connected to the control terminal of the high voltage charging power supply 1 . 本发明的有益效果是多参数动态调制的输出波型使磁场刺激变化丰富,感觉新鲜, 不容易产生适应性和耐受性,从而提高治疗效果。 Advantageous effects of the present invention is a multi-parameter dynamic modulated output waveform changes in the magnetic field stimulation is rich, fresh and not prone to tolerance and adaptability, thereby enhancing the therapeutic effect. 附图说明图1是本发明实施例的电路原理图。 BRIEF DESCRIPTION OF DRAWINGS FIG. 1 is a schematic circuit diagram of an embodiment of the present invention. 图2是调频输出波形和正弦调制波的示意图。 FIG 2 is a schematic diagram of the FM modulated output waveform of the sine wave. 图3是方波、三角波、锯齿波的示意图。 Figure 3 is a square wave, triangular wave, sawtooth schematic. 图4是梯形波、阶梯波、微分波和积分波的示意图。 FIG 4 is a schematic view of a trapezoidal wave, a stepped wave, wave differential and integral wave. 具体实施方式下面结合附图和实施例对本发明进一步说明。 The present invention is further illustrated figures and examples below in connection with specific embodiments. 图l标记的说明:l一髙压充电电源,2 —充电限流电阻,3—储能电容,4一反向续流二极管,5 —可控硅开关,6 —剌激线圈,7—微电脑控制器,8—上端取样电阻,9— 下端取样电阻,IO—比较器。 DESCRIPTION OF FIG labeled l: l Gao a charging power supply voltage, 2 - the charging current-limiting resistor, a 3-storage capacitor, a reverse freewheeling diode 4, 5 - triac, 6 - stimulation coil, 7- microcomputer controller, the upper end of sampling resistor 8-, 9- lower sampling resistor, IO- comparator. 图2中,上排波形为一般序列(丛状)波形,中间为正弦间调波形,下排为正弦连调波形。 In FIG. 2, the upper waveform is the general sequence (plexiform) waveform, between the intermediate sinusoidal tone waveforms, the lower row of tone waveform is sinusoidal. 图3中,上排为方波调制波形,中间为三角波调制波形,下排为锯齿波调制波形。 3, the upper row of modulation waveform is a square wave, triangular wave modulation waveform is intermediate, the discharge waveform is a sawtooth modulation. 图4中,上排为梯形波调制波形,中间为阶梯波调制波形,下排为微分波和积分波调制波形。 In FIG. 4, the upper trapezoidal wave modulation waveform, the middle step wave modulation waveform, and the lower row of integral differential wave modulation waveforms. 在图1中调制波的实现由微电脑控制器7的调制波指令程序经过PWM输出,通过滤波整形完成各种调制波形。 After the PWM output, perform various modulation waveform shaping by filtering the modulation wave in the implementation of FIG. 1 by the microcomputer controller 7 of the modulated wave instructions of the program. 髙压充电电源1受比较器10的控制,当比较器10输出为高电位时,高压充电电源1工作并通过限流电阻2向储能电容3充电,由上端取样电阻8和下端取样电阻9组成分压取样电路,检测储能电容3的电压,并接到比较器10的负极输入端,由微电脑控制器7按照调制波形的设置序列,作为给定电压接到比较器输入端的正极作为调制输入,当储能电容3的电压充到调制波形设定的电压时,取样电压微高于给定电压时,比较器10输出低电位,让髙压充电电源1停止工作,再由微电脑控制器7发出载波脉冲,触发可控硅开关5导通,由储能电容3通过可控硅开关完成向磁场刺激线圈6的放电;依次完成整个调制波周期。 Gao charging pressure is controlled by a power comparator 10, when the output of the comparator 10 is high, the work of high-voltage charging power supply 1 via the charging current limiting resistor 2 to the storage capacitor 3, a lower end and an upper end of sampling resistor 8 sampling resistor 9 composition dividing the sampling circuit, the storage capacitor voltage detector 3 and to the negative input of comparator 10, the positive electrode 7 is provided in accordance with the sequence modulation waveform, to a given voltage input of the comparator as a modulator of the microcomputer controller input, when the storage voltage of the capacitor 3 is charged to the voltage modulation waveform setting the sampling voltage slightly above a given voltage, the comparator 10 outputs a low potential, so that a charging power supply Gao pressure stopped, then the microcomputer controller 7 issued carrier pulse, triggered thyristor switch 5 is turned on, the magnetic coil 6 is discharged from the storage capacitor is completed by stimulation thyristor switch 3; in order to complete the entire cycle of the modulation wave. 在图2中,上排为调频的序列波输出波形;其序列波中的刺激频率是变化的,幅度不便。 In FIG. 2, the upper row is the waveform frequency modulated wave output sequence; stimulation frequency waves in the sequence is changed, the magnitude of inconvenience. 中间排为程序设计的正弦波间歇调制,其设置参数包括正弦调制波的频率(波宽)、 调制幅度(调制深度)、间歇时间,载波频率,最大输出量、最小输出量。 Middle row is intermittently modulated sine programming, set parameter comprises frequency of the sinusoidal wave modulation (pulse width), amplitude modulation (modulation depth), the time interval, the carrier frequency, the maximum output, minimum output. 其数学模型为:其中T是序列波工作周期(载波周期),A是调制幅度,N表示工作脉宽内的序列波个数。 The mathematical model is: where T is the sequence of wave period (carrier wave period), A is the amplitude modulation, N denotes the sequence number of the waves within the working width. 下排图是几个正弦波的连续调制,输出时间延长,间歇期縮短。 FIG lower row of several continuous sine wave modulation, the output time is lengthened or shortened intermittent. 其数学模型为:<formula>formula see original document page 5</formula>其中A表示调制频率,A是调制幅度。 The mathematical model is: <formula> formula see original document page 5 </ formula> where A represents the modulation frequency, A is the amplitude modulation. 在图3中,上排为两个方波连调后加一个间歇。 In Figure 3, the two rows of square waves even after adding a batch transfer. <formula>formula see original document page 5</formula>其中T是载波周期,N表示工作脉宽内的序列波个数。 <Formula> formula see original document page 5 </ formula> where T is the period of the carrier, N denotes the sequence number of the waves in the working width. M表示分段数,每段时间为NT/M,』,,/ = 1,2〜^是每段的幅度,中排为单个三角波调制波形,州=o 其他0^<a772其中T是序列波工作周期,A是幅度,N表示工作脉宽内的序列波个数,州=.A 0 ^ < 7m-《„ - 7;)" t; at /(at - t; ) do 其他下排为锯齿波调制波形,三角波的幅度、时程,锯齿波的上沿、下沿时间,调制幅度均可独立设定。 M represents the number of segments, each time NT / M, ',, / = 1,2~ ^ is the amplitude of each segment, in a single row of triangular modulation waveform, another state = o 0 ^ <a772 sequence wherein T is duty cycle wave, a is the amplitude, N denotes the sequence number of the waves in the working width, state = .A 0 ^ <7m- "" - 7;) "t; at / (at - t;) do the other row is,, the amplitude of the sawtooth modulation waveform when triangular wave drive sawtooth along the lower edge of the time, the modulation amplitude can be set independently. 数学模型为'爿/ 0s"7;-v47;〃(at-r2) +j7;at/(u2) :t2 a<#ro 其他其中T是序列波工作周期,A是幅度,N表示工作脉宽内的序列波个数。rw表示锯齿波调制信号最大值对应的时间点。在图4中,上排为梯形波调制,可设置上沿时间、下沿时间、平台时间,间歇时间, 调制度,载波频率,及输出量。数学模型为:—爿7;〃(at—r2) + ^7;at /(at—r2) r2 s, < at o 其他其中T是序列波工作周期,A是幅度,N表示调制波宽内的序列波个数。7!和7、是平台期的起点和终点。中间波形为阶梯波调制,可设置的参数为:阶梯数,阶梯时程,阶梯百分比级差, 最小与最大级差比。<formula>formula see original document page 6</formula>其中T是序列波工作周期,A是幅度,N表示调制脉宽内的序列波个数。下排为微分波和积分波(指数波和对数波),微分波起始变化小,变换量随时间的增加而成指数增大,积分 Mathematical model 'valves / 0s "7; -v47; 〃 (at-r2) + j7; at / (u2): t2 a <#ro other sequence where T is the duty cycle wave, A is the amplitude, N denotes the working pulse sequence number within .rw wave corresponding to the maximum width of the point in time represented by sawtooth modulation signal. in FIG. 4, the upper trapezoidal wave modulation, may be provided along the time, the next along the time, internet time, time interval, adjusting . system, the carrier frequency, and the output of the mathematical model: - valves 7; 〃 (at-r2) + ^ 7; at / (at-r2) r2 s, <at o other wherein T is a sequence of wave duty cycle, A amplitude, N denotes the sequence number of the waves in the pulse width modulation .7 and 7, is the starting point and end point of the platform intermediate step wave modulation waveform, the parameter can be set for:!. the number of steps, the step time course, the percentage of the step difference, with the minimum ratio of the maximum difference. <formula> formula see original document page 6 </ formula> where T is the sequence of the duty cycle wave, a is the amplitude, N denotes the sequence number of the waves in the pulse width modulation. lower row is a differential wave Points wave (wave number and wave index), a small change in the differential wave initiation, the amount of conversion increasing with time exponentially increases, integration 波相反,起始变化量大,随后变化小。其数学模型为:其中T是载波周期,A是幅度,N表示调制脉宽内的序列波个数。改变b值可改变调制曲线的凸凹程度。本发明所述的调制就是把各种标化的波形加载到在原来不变的序列(丛状)磁场刺激中,加载正弦波、方波、三角波、梯形波、阶梯波、锯齿波、指数波、对数波,(微分、积分波)递增、递减振荡波、可以改变调制波的频率和调制深度,并且磁场剌激频率也可以变化,成为双动态调制磁场刺激。多种组合波调制刺激,产生舒适愉悦的刺激, 富于变化的剌激,使磁场剌激更容易接受,达到更好的疗效。其他 Instead wave, the starting amount of change, and then a small change in the mathematical model: where T is a carrier cycle, A is the amplitude, N denotes the sequence number of the waves in the pulse width modulation may be changed to change the value b of degree of unevenness modulation curve the modulator according to the present invention is to various standardized waveforms loaded into the same original sequence (plexiform) magnetic stimulation, loading sine, square wave, triangular wave, a trapezoidal wave, a stepped wave, sawtooth, exponential wave of wave number (differential, integral wave) increasing, decreasing oscillation, and can change the frequency of the modulation depth of the modulated wave, and magnetic field stimulation frequency may also vary, becoming a double dynamically modulated magnetic stimulation. various combinations modulation wave stimulation produce comfortable and pleasant stimuli, richly varied stimulation, magnetic field stimulation more receptive to achieve better results. other

Claims (4)

1、一种经颅磁场刺激器刺激强度调制方法,其特征在于:各种变化的调制波和变化的刺激频率同时由微电脑控制器发出,经取样电路取样和比较器控制储能电容充电,使储能电容电压达到调制波给定值,再由微电脑控制器触发可控硅电子开关,实现磁场输出能量随着调制波和载波的变换而变化,成为双动态调幅调频波。 A method of intensity-modulated stimulation transcranial magnetic stimulator, comprising: varying the modulation wave and variations of the stimulation frequency emitted simultaneously by a microcomputer controller, and a comparator circuit sampling by the sampling control charging the storage capacitor, so that modulation wave energy storage capacitor voltage reaches a given value, then the electronic switch by the microcomputer triggered thyristor controller, the output power to achieve magnetic field change with the modulation wave and the carrier varies, becoming a double dynamic AM-FM wave.
2、 如权利要求1所述的经颅磁场剌激器剌激强度调制方法,其特征在于: 微电脑控制器(7)的调制波指令程序经过PWM输出,通过滤波整形完成各种调制波形;高压充电电源(1)在比较器(10)的控制下通过限流电阻(2)向储能电容(3) 充电;由上端取样电阻(8)和下端取样电阻(9)组成的分压取样电路检测储能电容(3) 的电压,由微电脑控制器(7)按照调制波形的设置序列,作为给定电压接到比较器输入端的正极作为调制输入,当储能电容(3)的电压充到调制波形设定的电压时,比较器(10)输出低电位,让高压充电电源(1)停止工作,再由微电脑控制器(7)发出载波脉冲,触发可控硅开关(5)导通,由储能电容(3)通过可控硅开关完成向磁场刺激线圈(6)的放电;依次完成整个调制波周期。 2, transcranial magnetic stimulation as claimed in claim 1, wherein the stimulation intensity modulation method, comprising: microcomputer controller (7) modulated wave PWM output through a program of instructions completed by various modulation waveform shaping filter; high pressure charging power supply (1) charged under control of the comparator (10) through a current limiting resistor (2) to the energy storage capacitor (3); the upper dividing a sampling circuit sampling resistor (8) and the lower end of sampling resistor (9) consisting of detecting the energy storage capacitor (3) is applied, by a microcomputer controller (7) is provided in accordance with the sequence modulation waveform as given voltage to the positive input of the comparator as the modulation input, when the voltage of the storage capacitor (3) to the charge when the voltage modulation waveform setting, the comparator (10) outputs a low voltage, so that high voltage charging power supply (1) is stopped, and then the carrier pulse sent by the microcomputer controller (7), the trigger triac (5) is turned on, a storage capacitor (3) is completed by the magnetic field stimulation triac discharge coil (6); in order to complete the entire cycle of the modulation wave.
3、 如权利要求1或2所述的经颅磁场刺激器刺激强度调制方法,其特征在于: 由微型计算机设置各种波形的数学模型,改变数学公式中的不同变量,改变调制波形,在电脑屏幕上显示多参数动态调制波形、载波频率、输出量、累计刺激个数、 刺激时间,调制波形为下列波形中的一种或多种:正弦波、方波、三角波、梯形波、 阶梯波、锯齿波、指数波、微分波,积分波,递增、递减振荡波,其调制深度,调制波宽,锯齿波、指数波、微分波、积分波上升沿和下降沿的时间、梯形波的平台时间, 阶梯波级数,重复次数均可调节,编制成输出波形时序图,成为变换丰富的治疗方案, 将其储存和调用。 3, transcranial magnetic stimulation as claimed in claim 1 or 2, wherein the stimulation intensity modulation method, comprising: setting various waveforms mathematical model of a microcomputer, changing different variables in a mathematical formula, change modulation waveform, the computer displayed on the screen multi-parameter dynamic modulation waveform, a carrier frequency, output, the cumulative number of stimuli, stimulus duration, the modulation waveform is one or more of the waveform: sinusoidal, square wave, triangular wave, a trapezoidal wave, a stepped wave, sawtooth, exponential waves, wave differential, integral wave, increasing, decreasing oscillation, its modulation depth, pulse width modulation, time internet sawtooth, exponential wave, differential wave, the rising and falling edges of the integral wave, trapezoidal wave , step wave series, the number of repetitions can be adjusted, a timing chart of output waveforms compiled, become rich conversion treatment regimen, which store and recall.
4、 一种刺激强度可调制的经颅磁场刺激器,它包括高压充电电源(1)、限流电阻(2)、储能电容(3)、反向续流二极管(4)、可控硅开关(5)、磁场刺激线圈(6)和微电脑控制器(7),其特征在于:它还包括上端取样电阻(8)、下端取样电阻(9)和比较器(10),上端取样电阻(8)和下端取样电阻(9)组成的分压取样电路并联在储能电容(3)上,中点接到比较器(10)的负极输入端,微电脑控制器(7)按照调制波形的设置序列,作为给定电压接到比较器输入端的正极作为调制输入,比较器(10) 的输出端连接高压充电电源U)的控制端。 4. A stimulus intensity may be modulated transcranial magnetic stimulator, comprising a high-voltage charging power source (1), the current limiting resistor (2), the energy storage capacitor (3), a reverse freewheeling diode (4), SCR the switch (5), magnetic stimulation coils (6) and a micro controller (7), characterized in that: an upper end further comprising a sampling resistor (8), the lower end of sampling resistor (9) and a comparator (10), the upper end of sampling resistor ( 8 according to the set modulation waveform) and lower sampling resistor (9) connected in parallel dividing the sampling circuit in the storage capacitor (3), connected to the midpoint of the comparator (10) input terminal of negative electrode, micro-controller (7) sequence, given as a positive voltage to the input of the comparator as the output of the modulator input, a comparator (10) is connected to high-voltage charging power source U) control terminal.
CN 200810046822 2008-01-29 2008-01-29 Transcranial magnetic field stimulator stimulus strength modulating method and device therefor CN101234233A (en)

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CN102284133A (en) * 2011-07-14 2011-12-21 申炳潮 A high-potential health treatment instrument
CN102309813A (en) * 2010-07-01 2012-01-11 林延龙 Electromagnetic stimulation device and method
CN102614592A (en) * 2012-04-13 2012-08-01 刘冀成 Transient electromagnetic field excitation system for transcranial magnetic stimulation (TMS) in medical field
CN105229995A (en) * 2013-02-22 2016-01-06 塞恩克公司 Methods and apparatuses for networking neuromodulation of a group of individuals
CN106178265A (en) * 2016-07-09 2016-12-07 大连理工大学 A kind of alternating magnetic field therapeutic apparatus realizes the method for stepless frequency modulation
US10258788B2 (en) 2015-01-05 2019-04-16 Thync Global, Inc. Electrodes having surface exclusions
US10293161B2 (en) 2013-06-29 2019-05-21 Thync Global, Inc. Apparatuses and methods for transdermal electrical stimulation of nerves to modify or induce a cognitive state
US10426945B2 (en) 2015-01-04 2019-10-01 Thync Global, Inc. Methods and apparatuses for transdermal stimulation of the outer ear
US10485972B2 (en) 2016-06-01 2019-11-26 Thync Global, Inc. Apparatuses and methods for neuromodulation

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* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN102309813A (en) * 2010-07-01 2012-01-11 林延龙 Electromagnetic stimulation device and method
CN102284133A (en) * 2011-07-14 2011-12-21 申炳潮 A high-potential health treatment instrument
CN102614592A (en) * 2012-04-13 2012-08-01 刘冀成 Transient electromagnetic field excitation system for transcranial magnetic stimulation (TMS) in medical field
CN105229995A (en) * 2013-02-22 2016-01-06 塞恩克公司 Methods and apparatuses for networking neuromodulation of a group of individuals
CN105229995B (en) * 2013-02-22 2019-05-21 赛威医疗公司 The method and apparatus of the nerve modulation of networking for one group of individual
US10293161B2 (en) 2013-06-29 2019-05-21 Thync Global, Inc. Apparatuses and methods for transdermal electrical stimulation of nerves to modify or induce a cognitive state
US10426945B2 (en) 2015-01-04 2019-10-01 Thync Global, Inc. Methods and apparatuses for transdermal stimulation of the outer ear
US10258788B2 (en) 2015-01-05 2019-04-16 Thync Global, Inc. Electrodes having surface exclusions
US10485972B2 (en) 2016-06-01 2019-11-26 Thync Global, Inc. Apparatuses and methods for neuromodulation
CN106178265B (en) * 2016-07-09 2018-08-07 大连理工大学 A kind of method that alternating magnetic field therapeutic apparatus realizes stepless frequency modulation
CN106178265A (en) * 2016-07-09 2016-12-07 大连理工大学 A kind of alternating magnetic field therapeutic apparatus realizes the method for stepless frequency modulation

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