CN109701161A - A method of stimulation brain motor cortex is twitched - Google Patents
A method of stimulation brain motor cortex is twitched Download PDFInfo
- Publication number
- CN109701161A CN109701161A CN201811523685.2A CN201811523685A CN109701161A CN 109701161 A CN109701161 A CN 109701161A CN 201811523685 A CN201811523685 A CN 201811523685A CN 109701161 A CN109701161 A CN 109701161A
- Authority
- CN
- China
- Prior art keywords
- voltage
- input
- stimulating coil
- value
- frequency
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
Landscapes
- Magnetic Treatment Devices (AREA)
Abstract
The embodiment of the present invention provides a kind of method that stimulation brain motor cortex is twitched, comprising: determines the first voltage value, magnetic field caused by input of the voltage with the first voltage value as stimulating coil reaches movement threshold to the stimulus intensity of brain motor cortex；According to the first voltage value, first frequency is determined, magnetic field caused by input of the pulse voltage with first frequency and the first amplitude as stimulating coil reaches twitch threshold value to the stimulus intensity of brain motor cortex, and the first amplitude is twice of the first voltage value；Driving voltage is generated according to the first voltage value and first frequency, driving voltage is input to stimulating coil and continues to input the first preset duration, so that magnetic stimulation brain motor cortex caused by stimulating coil is twitched, driving voltage is the pulse voltage with first frequency and the second amplitude, and the second amplitude is four times of the first voltage value.This method, which reaches, filters out effective, the smallest stimulation protocol of stimulus intensity in a short time to stimulate brain motor cortex to twitch.
Description
Technical field
The present embodiments relate to biostimulation technical fields, take out more particularly, to a kind of stimulation brain motor cortex
The method jerked.
Background technique
MST (Magnetic seizure therapy) technology is a kind of influence that the 1980s, mid-term grew up
With the biostimulation technology for changing cerebral function.And with the development of technology, it in terms of clinical medicine application it is also more next
The attention of people is more obtained, MST is to act on brain motor cortex using time-varying magnetic field to generate induced current change cortex neural
The action potential of cell to influence intracerebral metabolism and the movable biostimulation technology of neuroelectricity, and changes greatly for certain
The stimulation of brain function, it is desirable that brain motor cortex generates twitch.
Currently based on the equipment (such as transcranial magnetic stimulation instrument) of MST technology also in experimental stage, equipment moderate stimulation parameter
More, stimulation protocol combination is more, and setting is complicated, it is difficult to determine ideal stimulation protocol stimulation convulsive seizure.It can be in stimulation protocol
The irritating intensity of the parameter of adjusting (indicates) that stimulus intensity is by being input to the 1-100% of equipment maximum output magnetic field strength
The voltage value of stimulating coil come adjust, frequency of stimulation 1-100Hz is adjustable, frequency of stimulation is also the electricity by being input to stimulating coil
The frequency of pressure is adjusted, and stimulation time 1-10 seconds adjustable, stimulation time is held again by the voltage for being input to stimulating coil
Continuous input time is adjusted, and 3 parameters have 100 kinds of selections, shares 1003A permutation and combination can form 1,000,000 stimulations
Scheme, therefore select reasonable scheme highly difficult.Stimulation applications in present MST technology are gradually increased with 0.1Hz low frequency stimulating
Big stimulating dose, it is primary every stimulation in 10 seconds, the movement threshold (quantity of stimulus that minimum causes contraction of muscle) of individual is measured, then
Stimulation parameter is adjusted with the experience of ECT (Electric convulsive therapy), (minimum causes to take out measurement twitch threshold value
The quantity of stimulus jerked) with 100% output intensity, 100Hz frequency gradually increased the time of stimulation string every 20 seconds to determine twitch threshold
Value, it is determined that again threshold value multiplied by 2-4 times of quantity of stimulus after twitch threshold value, whole operation process needs manual operation, especially numerous
It is miscellaneous and time-consuming.Since stimulus intensity and frequency of stimulation are all 100%, only change stimulation time often there is overstimulation and
Unnecessary side effect occurs.And the difference due to human brain anatomical structure, the difference of physiology and pathological state, coil stimulation unit
The difference of position, the factors such as the changed difference of nervous function, each Neural stem cell difference in operation influence after twitch, are difficult MST
The scheme for being suitble to the rationalization of individuation is selected, currently without the mode of a general, fixed Induced by Stimulation twitch.Stimulation
It is difficult to select reasonably twitch quantity of stimulus and stimulating method in scheme, by being chosen over and debugging various stimulation protocols, quantity of stimulus
Too small to cause to twitch, stimulation is too strong in addition to requiring equipment to export more high-power, increase device fabrication difficulty, can also cause
Overstimulation, causes to have aches in the limbs or potential brain cell injury.
The stimulation parameter of 3 irritating intensity, frequency of stimulation and stimulation time routines in the stimulation protocol of MST technology, often
A parameter has 100 selectable value, and the selection of permutation and combination is ever-changing.If in addition TMS (Transcranial in recent years
Magnetic stimulation) increased couple stimulation, outburst stimulation formula and tetrad stimulate isotype, and stimulation protocol is even more
It is countless.Operator usually feels at a loss in face of numerous selections, is difficult to filter out in a short time effectively, most in short-term
Between, minimal stimulation induce twitch method.
Summary of the invention
In order to overcome the above problem or at least be partially solved the above problem, it is big that the embodiment of the present invention provides a kind of stimulation
The method of brain motor cortex twitch.
The embodiment of the present invention provides a kind of method that stimulation brain motor cortex is twitched, comprising: determine the first voltage value,
In, using the voltage with the first voltage value as the input of stimulating coil, so that brain is transported in magnetic field caused by stimulating coil
The stimulus intensity of dynamic cortex reaches movement threshold, and stimulating coil is placed in above brain motor cortex；According to the first voltage value, determine
First frequency, wherein using the pulse voltage with first frequency and the first amplitude as the input of stimulating coil, so that stimulation line
Magnetic field caused by enclosing reaches twitch threshold value to the stimulus intensity of brain motor cortex, and the first amplitude is the two of the first voltage value
Times；Driving voltage is generated according to the first voltage value and first frequency, driving voltage is input to stimulating coil and continues input the
One preset duration, so that magnetic stimulation brain motor cortex caused by stimulating coil is twitched, wherein driving voltage is with the
The pulse voltage of one frequency and the second amplitude, the second amplitude are four times of the first voltage value.
Wherein, driving voltage is input to stimulating coil and continues to input before the first preset duration, further includes: by frequency
Continuous 5 pulses are inputted to stimulating coil, so that magnetic caused by stimulating coil for the pulse voltage of 50Hz and third amplitude
Field carries out pre-stimulation to brain motor cortex, wherein third amplitude is second voltage value, and second voltage value is no more than first voltage
Value.
Wherein, driving voltage is input to stimulating coil and continues to input after the first preset duration, further includes: obtained and drive
Voltage input is moved to stimulating coil, so that the first blood pressure after magnetic stimulation brain motor cortex caused by stimulating coil is believed
Number；If it is determined that the intensity of the first blood pressure signal does not meet preset condition, then after the second preset duration, thorn is input to based on previous
The continuous input time for swashing the driving voltage of coil, is stepped up driving voltage with the first preset step-length and is input to stimulating coil
Continuous input time, until determining that the intensity of the first blood pressure signal meets the continuous input time of preset condition or driving voltage
Reach duration upper limit value, wherein preset condition is that the intensity of the first blood pressure signal is more than holding for default blood pressure intensity threshold
The continuous time is at least third preset duration.
Wherein, the continuous input time based on the previous driving voltage for being input to stimulating coil, with the first preset step-length by
Step increases driving voltage and is input to after the continuous input time of stimulating coil, further includes: if it is determined that continuing for driving voltage is defeated
The angle of incidence reaches duration upper limit value and the intensity of the first blood pressure signal does not meet preset condition, then in the second preset duration
Afterwards, the pulse voltage with second frequency and the 4th amplitude is input to stimulating coil and continues input duration upper limit value,
So that magnetic stimulation brain motor cortex caused by stimulating coil is twitched, second frequency is upper frequency limit value, and the 4th amplitude is
Upper voltage limit.
Wherein it is determined that the first voltage value, comprising: one by one extremely stimulate the first test pulse voltage input that frequency is 50Hz
Coil, each the first test pulse voltage for being input to stimulating coil continue 5 pulses, the vibration of latter first test pulse voltage
Width is increased based on the amplitude of previous first test pulse voltage with the second preset step-length；Every time that the first test pulse voltage is defeated
Enter to stimulating coil, obtains the first test pulse voltage input to stimulating coil, so that magnetic field caused by stimulating coil is pierced
Myoelectric complex signal after swashing brain motor cortex, until the maximum value for determining myoelectric complex signal is more than the first preset value；It will
The amplitude of the maximum value of myoelectric complex signal corresponding first test pulse voltage when being more than the first preset value is as first voltage
Value.
Wherein, according to the first voltage value, first frequency is determined, comprising: one by one by the second test arteries and veins with the first amplitude
Voltage input is rushed to stimulating coil, each the second test pulse voltage for being input to stimulating coil persistently input the 4th it is default when
Long, the frequency of latter second test pulse voltage is based on the frequency of previous second test pulse voltage with the increasing of third preset step-length
Add；After every time by the second test pulse voltage input to stimulating coil, the second test pulse voltage input is obtained to stimulating line
Circle, so that the second blood pressure signal after magnetic stimulation brain motor cortex caused by stimulating coil, until determining the second blood pressure
The maximum value of signal is more than the second preset value；Corresponding second surveys when by the maximum value of the second blood pressure signal more than the second preset value
The frequency of pulse voltage is tried as first frequency.
A kind of method that stimulation brain motor cortex is twitched provided in an embodiment of the present invention, comprising: determine the first voltage value,
Wherein, input of the voltage with the first voltage value as stimulating coil, so that brain is transported in magnetic field caused by stimulating coil
The stimulus intensity of dynamic cortex reaches movement threshold, and stimulating coil is placed in above brain motor cortex；According to the first voltage value, determine
First frequency, wherein input of the pulse voltage with first frequency and the first amplitude as stimulating coil, so that stimulating coil
Generated magnetic field reaches twitch threshold value to the stimulus intensity of brain motor cortex, and the first amplitude is twice of the first voltage value；
Driving voltage is generated according to the first voltage value and first frequency, driving voltage is input to stimulating coil and continues input first in advance
If duration, so that magnetic stimulation brain motor cortex caused by stimulating coil is twitched, wherein driving voltage is with the first frequency
The pulse voltage of rate and the second amplitude, the second amplitude are four times of the first voltage value.This method determines first according to movement threshold
Voltage value, and first frequency is determined according to twitch threshold value, driving voltage is generated further according to the first voltage value and first frequency, is passed through
Driving voltage drives stimulating coil to generate magnetic field, and stimulation brain motor cortex is twitched, filtered out in a short time to reach
Effect, the smallest stimulation protocol of stimulus intensity come stimulate brain motor cortex twitch.
Detailed description of the invention
In order to more clearly explain the embodiment of the invention or the technical proposal in the existing technology, to embodiment or will show below
There is attached drawing needed in technical description to be briefly described, it should be apparent that, the accompanying drawings in the following description is this hair
Bright some embodiments for those of ordinary skill in the art without creative efforts, can be with root
Other attached drawings are obtained according to these attached drawings.
Fig. 1 is the flow chart for the method twitched according to the stimulation brain motor cortex of the embodiment of the present invention；
Fig. 2 is the schematic diagram for the device twitched according to the stimulation brain motor cortex of the embodiment of the present invention.
Specific embodiment
In order to make the object, technical scheme and advantages of the embodiment of the invention clearer, below in conjunction with the embodiment of the present invention
In attached drawing, technical scheme in the embodiment of the invention is clearly and completely described, it is clear that described embodiment is
A part of the embodiment of the present invention, instead of all the embodiments.Based on the embodiments of the present invention, those of ordinary skill in the art
Every other embodiment obtained without creative efforts, shall fall within the protection scope of the present invention.
The embodiment of the present invention provides a kind of method that stimulation brain motor cortex is twitched, with reference to Fig. 1, comprising: S11 is determined
The first voltage value, wherein using the voltage with the first voltage value as the input of stimulating coil, so that caused by stimulating coil
Magnetic field reaches movement threshold to the stimulus intensity of brain motor cortex, and stimulating coil is placed in above brain motor cortex；S12, root
According to the first voltage value, first frequency is determined, wherein using the pulse voltage with first frequency and the first amplitude as stimulating coil
Input so that magnetic field caused by stimulating coil reaches twitch threshold value, the first amplitude to the stimulus intensity of brain motor cortex
It is twice of the first voltage value；S13 generates driving voltage according to the first voltage value and first frequency, driving voltage is input to
Stimulating coil simultaneously continues to input the first preset duration, so that magnetic stimulation brain motor cortex caused by stimulating coil is twitched,
Wherein, driving voltage is the pulse voltage with first frequency and the second amplitude, and the second amplitude is four times of the first voltage value.
Specifically, equipment, such as transcranial magnetic stimulation instrument based on MST technology etc. mainly include storage capacitor, it is silicon-controlled with
And stimulating coil, wherein storage capacitor can provide constant voltage, then stimulation is input to after pulse voltage is made in thyristor regulating
In coil, stimulating coil generated under the action of pulse voltage with the transient magnetic field of pulse voltage same frequency, the intensity in magnetic field by
The amplitude of pulse voltage is determined that the duration in magnetic field is determined by the lasting input duration for being input to the voltage of stimulating coil,
Stimulus intensity (i.e. magnetic field strength), frequency of stimulation (i.e. the frequency in magnetic field) and thorn in stimulation protocol as a result, based on MST technology
Swash time (i.e. the duration in magnetic field) to be determined by the voltage value, frequency and the duration that are input to the voltage of stimulating coil respectively
It is fixed, determine that stimulation protocol namely determines voltage value, frequency and the duration for being input to the voltage of stimulating coil.
In order to filter out effective, the smallest stimulation protocol of stimulus intensity in a short time, the present embodiment determines the first
One voltage value, wherein using the voltage with the first voltage value as the input of stimulating coil, generated magnetic field moves brain
The stimulus intensity of cortex reaches movement threshold, and stimulating coil is placed in above brain motor cortex to guarantee caused by stimulating coil
Magnetic field generates effective stimulation to brain motor cortex；Movement threshold is the minimum stimulation intensity for causing contraction of muscle, based on fortune
Dynamic threshold value determines the first voltage value, can guarantee that the first voltage value is optional minimum value；Then it according to the first voltage value, determines
First frequency, wherein using the pulse voltage with first frequency and the first amplitude as the input of stimulating coil, generated magnetic
Field reaches twitch threshold value to the stimulus intensity of brain motor cortex, wherein the first amplitude is twice of the first voltage value, threshold of twitching
Value refers to the minimum stimulation intensity for causing twitch, and based on first frequency determined by threshold value of twitching, can guarantee that first frequency is can
The minimum value of choosing；Finally, generate driving voltage according to the first voltage value and first frequency, driving voltage be with first frequency and
Driving voltage is input to stimulating coil and continues to input the first preset duration by the pulse voltage of the second amplitude, so that stimulation line
Enclose caused by magnetic stimulation brain motor cortex twitch, wherein the amplitude of driving voltage be the first voltage value multiple and
The continuous input time of driving voltage can determine that the second amplitude in the present embodiment is the four of the first voltage value according to historical experience
Times, the first preset duration can be selected six seconds；The first voltage value can be converted into the percentage of the maximum tank voltage of storage capacitor, example
Such as, it is 20% that the first voltage value, which can be converted into the percentage of the maximum tank voltage of storage capacitor, then the amplitude of driving voltage is
The 80% of the maximum tank voltage of storage capacitor.Driving voltage is generated by above-mentioned the first voltage value and first frequency, to protect
Card quickly determines the amplitude of driving voltage and the lower limit value of frequency, is further ensured that and filters out effective, stimulation in a short time
The smallest stimulation protocol of intensity come stimulate brain motor cortex twitch, avoid stimulus intensity excessive and cause side effect.
Above-mentioned driving voltage can be generated by device as shown in Figure 2 and be input to stimulating coil to complete to move brain
The stimulation of cortex, wherein whether 1 control single chip computer of switch starts, single-chip microcontroller 2 controls the charge volume and silicon-controlled 4 of storage capacitor 3
Switching frequency, the voltage input of storage capacitor 3 is modulated into through silicon-controlled 4 the switching frequency with silicon-controlled 4 to silicon-controlled 4
The pulse voltage of same frequency, pulse voltage generated are driving voltage, and driving voltage is input to above human brain 6
Stimulating coil 5, the stimulation to brain motor cortex is realized in generated magnetic field.
The method that the stimulation brain motor cortex of the present embodiment is twitched, determines the first voltage value, and root according to movement threshold
First frequency is determined according to twitch threshold value, is generated driving voltage further according to the first voltage value and first frequency, is driven by driving voltage
Dynamic stimulating coil generation magnetic field, stimulation brain motor cortex are twitched, and filter out effective, stimulation in a short time by force to reach
The smallest stimulation protocol is spent to stimulate brain motor cortex to twitch.
Based on above embodiments, before driving voltage is input to stimulating coil and continues to input the first preset duration, also
Including: is 50Hz by frequency and the pulse voltage of third amplitude inputs continuous 5 pulses to stimulating coil, so that stimulating coil
Generated magnetic field carries out pre-stimulation to brain motor cortex, wherein third amplitude is second voltage value, and second voltage value does not surpass
Cross the first voltage value.
Specifically, the present embodiment using driving voltage driving stimulating coil generate magnetic stimulation brain motor cortex it
Before, pre-stimulation is also carried out to brain motor cortex by the relatively weak magnetic field of stimulus intensity, this pre-stimulation can improve brain
The excitability of motor cortex realizes brain movement by Low Intensity Pulsed Magnetic Fields to be easier to realize to reduce twitch threshold value
The twitch of cortex；The above-mentioned magnetic field for carrying out pre-stimulation to brain motor cortex can be the pulse of 50Hz and third amplitude by frequency
Voltage drives stimulating coil to generate, and 5 pulses of Continuous Drive, wherein third amplitude is second voltage value, and second voltage value is not
More than the first voltage value.
Based on above embodiments, driving voltage is input to stimulating coil and is continued after inputting the first preset duration, also
It include: to obtain driving voltage to be input to stimulating coil, so that after magnetic stimulation brain motor cortex caused by stimulating coil
First blood pressure signal；If it is determined that the intensity of the first blood pressure signal does not meet preset condition, then after the second preset duration, before being based on
One is input to the continuous input time of the driving voltage of stimulating coil, is stepped up driving voltage with the first preset step-length and is input to
The continuous input time of stimulating coil, until determining that the intensity of the first blood pressure signal meets holding for preset condition or driving voltage
Continuous input time reaches duration upper limit value, wherein preset condition is that the intensity of the first blood pressure signal is more than that default blood pressure is strong
The duration of degree threshold value is at least third preset duration.
Specifically, whether twitch is generated for brain motor cortex, can be determined by blood pressure signal, blood pressure signal can lead to
The received cuff pressure signal of sphygmomanometer is crossed to obtain, it is as follows to determine that the decision condition of brain motor cortex generation twitch may be set to
Preset condition: the intensity of the first blood pressure signal is more than the duration of default blood pressure intensity threshold to be at least third preset duration,
Wherein, the first blood pressure signal is that driving voltage is input to after magnetic stimulation brain motor cortex caused by stimulating coil by blood pressure
The blood pressure signal of measurement is counted, blood pressure intensity threshold can determine that third preset duration may be set to 10 seconds according to historical data.
If driving voltage is input to the first blood pressure signal after magnetic stimulation brain motor cortex caused by stimulating coil
Intensity do not meet preset condition, then illustrate that brain motor cortex is not yet twitched, can be after the second preset duration, second is pre-
If duration can be set as 20 seconds, increase the input time that driving voltage is input to stimulating coil, to keep the magnetic field pair of longer time
The stimulation of brain motor cortex, lasting input of the increased input time based on the previous driving voltage for being input to stimulating coil
Time is stepped up with the first preset step-length, and to be stepped up the stimulus intensity to brain motor cortex, the first preset step-length can
It is set as 1 second, until determining that the intensity of the first blood pressure signal meets preset condition or the continuous input time of driving voltage reaches
Duration upper limit value, wherein duration upper limit value is 10 seconds, which is in order to avoid moving to brain
The excessively prolonged stimulation of cortex, avoids causing adverse effect to human body.
The above process can also be realized by device as shown in Figure 2, wherein the second preset duration and the first default step
Length can control silicon-controlled 4 by single-chip microcontroller 2 to realize, the first blood pressure signal can be obtained by the sphygmomanometer in detecting instrument 7
Take, can also carry out auxiliary detection by the electroencephalograph in detecting instrument 7 and electromyograph(EMG, the parameters of various stimulus signals with
And the detection signal such as blood pressure signal can be shown by display screen 8.
Based on above embodiments, based on the continuous input time of the previous driving voltage for being input to stimulating coil, with first
Preset step-length is stepped up driving voltage and is input to after the continuous input time of stimulating coil, further includes: if it is determined that driving electricity
The continuous input time of pressure reaches duration upper limit value and the intensity of the first blood pressure signal does not meet preset condition, then second
After preset duration, the pulse voltage with second frequency and the 4th amplitude is input to stimulating coil and continues input duration
Upper limit value so that magnetic stimulation brain motor cortex caused by stimulating coil twitch, second frequency be upper frequency limit value, the 4th
Amplitude is upper voltage limit.
Specifically, if under conditions of the continuous input time of driving voltage reaches duration upper limit value, brain moves skin
Layer is then guaranteeing the maximum output value in human body receiving using equipment, brain motor cortex is made to twitch there are no twitching,
In, upper frequency limit value is 100Hz, upper voltage limit is storage capacitor maximum output voltage, driving voltage are input to stimulation line
The duration upper limit value of circle is 10 seconds.
Based on above embodiments, the first voltage value is determined, comprising: the first test pulse voltage for being one by one 50Hz by frequency
It is input to stimulating coil, each the first test pulse voltage for being input to stimulating coil continues 5 pulses, latter first test arteries and veins
The amplitude for rushing voltage is increased based on the amplitude of previous first test pulse voltage with the second preset step-length；Every time by the first test
After pulse voltage is input to stimulating coil, the first test pulse voltage input is obtained to stimulating coil, so that stimulating coil is produced
Myoelectric complex signal after raw magnetic stimulation brain motor cortex, until the maximum value for determining myoelectric complex signal is more than first
Preset value；When being more than the first preset value for the maximum value of myoelectric complex signal the amplitude of corresponding first test pulse voltage as
The first voltage value.
Specifically, the first voltage value is determined by being input to the first test pulse voltage of stimulating coil one by one, wherein the
The frequency of one test pulse voltage is 50Hz, continues 5 pulses, and the amplitude of latter first test pulse voltage is based on previous
The amplitude of first test pulse voltage is increased with the second preset step-length, and the second preset step-length can be according to the maximum output of storage capacitor
The percentages of voltage, the amplitude of first the first test pulse voltage for being input to stimulating coil are that the maximum of storage capacitor is defeated
The 20% of voltage out obtains the first test pulse voltage input to thorn after the first test pulse voltage input to stimulating coil
Myoelectric complex signal after swashing magnetic stimulation brain motor cortex caused by coil, myoelectric complex signal can be by the inspection of such as Fig. 2
The electromyograph(EMG in instrument in 7 is surveyed to measure, if the maximum value of myoelectric complex signal is less than the first preset value, this is first pre-
If value can be set as 50uV, then illustrate possessed by the magnetic field generated after the first test pulse voltage input to stimulating coil at this time
Stimulus intensity is not up to movement threshold, then increases the amplitude of the first test pulse voltage, the second default step by the second preset step-length
Length can be set as the 5% of the maximum output voltage of storage capacitor, and repeat the above process, until the myoelectric complex signal tested
Maximum value is more than the first preset value, corresponding first test pulse when by the maximum value of myoelectric complex signal more than the first preset value
The amplitude of voltage is as the first voltage value.
First frequency is determined according to the first voltage value based on above embodiments, comprising: will there is the first amplitude one by one
For second test pulse voltage input to stimulating coil, each the second test pulse voltage for being input to stimulating coil persistently inputs
The frequency of four preset durations, latter second test pulse voltage is default with third based on the frequency of previous second test pulse voltage
Step-length increases；After every time by the second test pulse voltage input to stimulating coil, the second test pulse voltage input is obtained extremely
Stimulating coil, so that the second blood pressure signal after magnetic stimulation brain motor cortex caused by stimulating coil, until determining the
The maximum value of two blood pressure signals is more than the second preset value；It is corresponding when by the maximum value of the second blood pressure signal more than the second preset value
The frequency of second test pulse voltage is as first frequency.
Specifically, one by one by the second test pulse voltage input with the first amplitude to stimulating coil, the first amplitude is
Twice of the first voltage value, each the second test pulse voltage for being input to stimulating coil persistently input the 4th preset duration, should
Second test pulse voltage can be generated by device as shown in Figure 2, wherein the 4th preset duration can be set as 6 seconds, and latter second surveys
The frequency for trying pulse voltage is increased based on the frequency of previous second test pulse voltage with third preset step-length, wherein first
The frequency of second test pulse voltage is 20Hz, and third preset step-length can be set as 10Hz；Every time by the second test pulse voltage
After being input to stimulating coil, obtains magnetic stimulation brain caused by the second test pulse voltage input to stimulating coil and move skin
The second blood pressure signal after layer, wherein the second blood pressure signal can be measured by the sphygmomanometer in the detecting instrument of such as Fig. 27, directly
It is more than the second preset value to the maximum value for determining the second blood pressure signal, wherein the second preset value can be determined according to historical data；
The frequency of corresponding second test pulse voltage is as the first frequency when using the maximum value of the second blood pressure signal more than the second preset value
Rate.
Finally, it is stated that: the above embodiments are merely illustrative of the technical solutions of the present invention, rather than its limitations；Although ginseng
According to previous embodiment, invention is explained in detail, those skilled in the art should understand that: it still can be with
It modifies the technical solutions described in the foregoing embodiments or equivalent replacement of some of the technical features；And
These are modified or replaceed, the spirit and model of technical solution of various embodiments of the present invention that it does not separate the essence of the corresponding technical solution
It encloses.
Claims (6)
1. a kind of method that stimulation brain motor cortex is twitched characterized by comprising
Determine the first voltage value, wherein using the voltage with the first voltage value as the input of stimulating coil, so that described
Magnetic field caused by stimulating coil reaches movement threshold to the stimulus intensity of brain motor cortex, and the stimulating coil is placed in described
Above brain motor cortex；
According to the first voltage value, first frequency is determined, wherein by the pulse electricity with the first frequency and the first amplitude
The input as the stimulating coil is pressed, so that stimulus intensity of the magnetic field caused by the stimulating coil to brain motor cortex
Reach twitch threshold value, first amplitude is twice of the first voltage value；
Driving voltage is generated according to the first voltage value and the first frequency, the driving voltage is input to the stimulation
Coil simultaneously continues to input the first preset duration, so that brain motor cortex described in magnetic stimulation caused by the stimulating coil is taken out
It jerks, wherein the driving voltage is the pulse voltage with the first frequency and the second amplitude, and second amplitude is described
Four times of the first voltage value.
2. the method according to claim 1, wherein described be input to the stimulating coil for the driving voltage
And continue to input before the first preset duration, further includes:
By frequency be 50Hz and the pulse voltage of third amplitude inputs continuous 5 pulses to the stimulating coil, so that described
Magnetic field caused by stimulating coil carries out pre-stimulation to the brain motor cortex, wherein the third amplitude is second voltage
Value, the second voltage value are no more than the first voltage value.
3. the method according to claim 1, wherein described be input to the stimulating coil for the driving voltage
And continue to input after the first preset duration, further includes:
It obtains the driving voltage and is input to the stimulating coil, so that magnetic stimulation brain caused by the stimulating coil is transported
The first blood pressure signal after dynamic cortex；
If it is determined that the intensity of first blood pressure signal does not meet preset condition, then after the second preset duration, based on previous defeated
Enter to the continuous input time of the driving voltage of the stimulating coil, the driving electricity is stepped up with the first preset step-length
Pressure is input to the continuous input time of the stimulating coil, until it is described default to determine that the intensity of first blood pressure signal meets
The continuous input time of condition or the driving voltage reaches duration upper limit value, wherein the preset condition is described
The intensity of first blood pressure signal is more than the duration of default blood pressure intensity threshold to be at least third preset duration.
4. according to the method described in claim 3, it is characterized in that, described be input to described in the stimulating coil based on previous
The continuous input time of driving voltage is stepped up the driving voltage with the first preset step-length and is input to the stimulating coil
After continuous input time, further includes:
If it is determined that the continuous input time of the driving voltage reaches the strong of duration upper limit value and first blood pressure signal
Degree does not meet the preset condition, then after the second preset duration, the pulse voltage with second frequency and the 4th amplitude is defeated
Enter to the stimulating coil and continue to input the duration upper limit value, so that magnetic stimulation caused by the stimulating coil
The brain motor cortex twitch, the second frequency are upper frequency limit value, and the 4th amplitude is upper voltage limit.
5. the method according to claim 1, wherein the determining the first voltage value, comprising:
One by one by frequency be 50Hz the first test pulse voltage input to the stimulating coil, it is each to be input to the stimulation line
First test pulse voltage of circle continues 5 pulses, and the amplitude of latter first test pulse voltage is based on previous first test arteries and veins
The amplitude of voltage is rushed to increase with the second preset step-length；
After every time by the first test pulse voltage input to the stimulating coil, the first test pulse voltage input is obtained to institute
Stimulating coil is stated, so that the myoelectric complex signal after magnetic stimulation brain motor cortex caused by the stimulating coil, until
The maximum value for determining the myoelectric complex signal is more than the first preset value；
Corresponding first test pulse voltage when by the maximum value of the myoelectric complex signal more than first preset value
Amplitude as the first voltage value.
6. the method according to claim 1, wherein described determine first frequency according to the first voltage value,
Include:
One by one by the second test pulse voltage input with first amplitude to the stimulating coil, it is each be input to it is described
Second test pulse voltage of stimulating coil persistently inputs the 4th preset duration, and the frequency of latter second test pulse voltage is based on
The frequency of previous second test pulse voltage is with the increase of third preset step-length；
After every time by the second test pulse voltage input to the stimulating coil, the second test pulse voltage input is obtained
The extremely stimulating coil, so that the second blood pressure signal after magnetic stimulation brain motor cortex caused by the stimulating coil,
Until the maximum value for determining second blood pressure signal is more than the second preset value；
Corresponding second test pulse voltage when by the maximum value of second blood pressure signal more than second preset value
Frequency as the first frequency.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201811523685.2A CN109701161B (en) | 2018-12-13 | 2018-12-13 | Method for stimulating cerebral motor cortex twitch |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201811523685.2A CN109701161B (en) | 2018-12-13 | 2018-12-13 | Method for stimulating cerebral motor cortex twitch |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| CN109701161A true CN109701161A (en) | 2019-05-03 |
| CN109701161B CN109701161B (en) | 2023-05-12 |
Family
ID=66256254
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN201811523685.2A Active CN109701161B (en) | 2018-12-13 | 2018-12-13 | Method for stimulating cerebral motor cortex twitch |
Country Status (1)
| Country | Link |
|---|---|
| CN (1) | CN109701161B (en) |
Citations (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US20030073899A1 (en) * | 2001-10-17 | 2003-04-17 | Jarmo Ruohonen | Method and apparatus for dose computation of magnetic stimulation |
| CN101234233A (en) * | 2008-01-29 | 2008-08-06 | 武汉依瑞德医疗设备新技术有限公司 | Transcranial magnetic field stimulator stimulus strength modulating method and device therefor |
| CN201286940Y (en) * | 2008-01-25 | 2009-08-12 | 武汉依瑞德医疗设备新技术有限公司 | Via-skull magnetic field stimulator with multi stimulation coils |
| CN202143753U (en) * | 2011-07-15 | 2012-02-15 | 沈阳助邦科技有限公司 | Transcranial magnetic biofeedback apparatus |
| CN104001266A (en) * | 2014-06-13 | 2014-08-27 | 中国医学科学院生物医学工程研究所 | Method for determining transcranial magnetic stimulation (TMS) amount based on distance measurement |
| CN104587605A (en) * | 2015-01-11 | 2015-05-06 | 北京工业大学 | Electromyographic signal controlled peripheral magnetic stimulation system and method |
| CN105688333A (en) * | 2016-01-12 | 2016-06-22 | 中国人民解放军军事医学科学院基础医学研究所 | Nerve effect evaluation apparatus of external transcranial magnetic stimulation |
| CN107497051A (en) * | 2017-09-25 | 2017-12-22 | 深圳市神经科学研究院 | A kind of trans-skull magnetic stimulating device and transcranial magnetic stimulation method of near infrared signal control |
-
2018
- 2018-12-13 CN CN201811523685.2A patent/CN109701161B/en active Active
Patent Citations (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US20030073899A1 (en) * | 2001-10-17 | 2003-04-17 | Jarmo Ruohonen | Method and apparatus for dose computation of magnetic stimulation |
| CN201286940Y (en) * | 2008-01-25 | 2009-08-12 | 武汉依瑞德医疗设备新技术有限公司 | Via-skull magnetic field stimulator with multi stimulation coils |
| CN101234233A (en) * | 2008-01-29 | 2008-08-06 | 武汉依瑞德医疗设备新技术有限公司 | Transcranial magnetic field stimulator stimulus strength modulating method and device therefor |
| CN202143753U (en) * | 2011-07-15 | 2012-02-15 | 沈阳助邦科技有限公司 | Transcranial magnetic biofeedback apparatus |
| CN104001266A (en) * | 2014-06-13 | 2014-08-27 | 中国医学科学院生物医学工程研究所 | Method for determining transcranial magnetic stimulation (TMS) amount based on distance measurement |
| CN104587605A (en) * | 2015-01-11 | 2015-05-06 | 北京工业大学 | Electromyographic signal controlled peripheral magnetic stimulation system and method |
| CN105688333A (en) * | 2016-01-12 | 2016-06-22 | 中国人民解放军军事医学科学院基础医学研究所 | Nerve effect evaluation apparatus of external transcranial magnetic stimulation |
| CN107497051A (en) * | 2017-09-25 | 2017-12-22 | 深圳市神经科学研究院 | A kind of trans-skull magnetic stimulating device and transcranial magnetic stimulation method of near infrared signal control |
Also Published As
| Publication number | Publication date |
|---|---|
| CN109701161B (en) | 2023-05-12 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| EP3513836B1 (en) | Magnetic field applicator having a ramped signal of the solenoid valve current used | |
| Fuortes et al. | Steps in the production of motoneuron spikes | |
| RU1799577C (en) | Method for improving vision function affected by ophthalmic nerve and retina disease | |
| US7024247B2 (en) | Systems and methods for reducing the likelihood of inducing collateral neural activity during neural stimulation threshold test procedures | |
| CN108778409A (en) | Method and system for the offer for improving electro photoluminescence | |
| JP6717824B2 (en) | Devices and software for effective non-invasive neural stimulation with various stimulation sequences | |
| WO2014202755A1 (en) | Magnetic stimulator for stimulating tissue with a magnetic field | |
| CN109963609A (en) | Brain stimulation device and application thereof | |
| CN104768449A (en) | Device and method for examining a phase distribution used to determine a pathological interaction between different areas of the brain | |
| CN106175690A (en) | S sleep strengthens system and S sleep monitoring method | |
| DE102017108084B4 (en) | Pulse source and method for magnetically inductive nerve stimulation | |
| Merton et al. | Indirect and direct stimulation of fatigued human muscle | |
| CN101985058A (en) | Multi-functional transcranial magnetic stimulator | |
| US20160199662A1 (en) | System and method for non-invasive neuronal stimulation | |
| EP2051773B1 (en) | Device for stimulation by means of electric and magnetic fields, and field applicators for this purpose | |
| CN112843477A (en) | Transcranial magnetic acoustic electrical stimulation brain regulation and control device and transcranial magnetic acoustic electrical stimulation brain regulation and control method | |
| CN203556061U (en) | Transcranial stimulation apparatus | |
| Gebhard | Thresholds of the human eye for electric stimulation by different wave forms. | |
| CN103893915A (en) | Biological self-feedback sleep monitoring magnetic therapy apparatus | |
| EP0203336B1 (en) | Electrical stimulator and method for treatment of the human and animal body with stimulation currents | |
| CN109701161A (en) | A method of stimulation brain motor cortex is twitched | |
| CN107206236A (en) | By the apparatus and method of effective intrusive mood nerve stimulation of the stimulus sequence of change | |
| CN107510890A (en) | Functional brain deep brain stimulation control system and method | |
| Fallon et al. | Principles of recording from and electrical stimulation of neural tissue | |
| CN115887911A (en) | Nerve regulation and control method and device with stimulation and induction loops |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| PB01 | Publication | ||
| PB01 | Publication | ||
| SE01 | Entry into force of request for substantive examination | ||
| SE01 | Entry into force of request for substantive examination | ||
| GR01 | Patent grant | ||
| GR01 | Patent grant |